WO2011091410A8 - Trpv4 antagonists - Google Patents
Trpv4 antagonists Download PDFInfo
- Publication number
- WO2011091410A8 WO2011091410A8 PCT/US2011/022380 US2011022380W WO2011091410A8 WO 2011091410 A8 WO2011091410 A8 WO 2011091410A8 US 2011022380 W US2011022380 W US 2011022380W WO 2011091410 A8 WO2011091410 A8 WO 2011091410A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- trpv4 antagonists
- trpv4
- antagonists
- indole
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
The present invention relates to indole or benzothiophene analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29786410P | 2010-01-25 | 2010-01-25 | |
| US61/297,864 | 2010-01-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2011091410A1 WO2011091410A1 (en) | 2011-07-28 |
| WO2011091410A8 true WO2011091410A8 (en) | 2011-11-24 |
Family
ID=44307279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2011/022380 WO2011091410A1 (en) | 2010-01-25 | 2011-01-25 | Trpv4 antagonists |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2011091410A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2832731A4 (en) | 2012-03-27 | 2015-08-19 | Shionogi & Co | Aromatic heterocyclic five-membered ring derivative having trpv4 inhibitory activity |
| WO2015046193A1 (en) | 2013-09-25 | 2015-04-02 | 塩野義製薬株式会社 | Aromatic heterocyclic amine derivative having trpv4 inhibiting activity |
| CN107074771B (en) * | 2014-08-28 | 2020-03-20 | X-化学有限公司 | Soluble epoxide hydrolase inhibitors and uses thereof |
| DK3240785T3 (en) | 2014-12-29 | 2021-09-27 | Us Health | SMALL MOLECULATE INHIBITORIES OF LACTASE DEHYDROGENASIS AND PROCEDURES FOR USE |
| WO2022014707A1 (en) | 2020-07-16 | 2022-01-20 | ラクオリア創薬株式会社 | Trpv4 inhibitor as therapeutic drug for eye disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008512461A (en) * | 2004-09-07 | 2008-04-24 | スミスクライン・ビーチャム・コーポレイション | New compounds |
| WO2007070865A2 (en) * | 2005-12-15 | 2007-06-21 | Smithkline Beecham Corporation | Piperazine compounds as agonists of trpv4 channel receptors |
-
2011
- 2011-01-25 WO PCT/US2011/022380 patent/WO2011091410A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011091410A1 (en) | 2011-07-28 |
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