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WO2011055383A3 - Intranasal delivery to improve the performance of children suffering from dyslexia - Google Patents

Intranasal delivery to improve the performance of children suffering from dyslexia Download PDF

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Publication number
WO2011055383A3
WO2011055383A3 PCT/IN2010/000719 IN2010000719W WO2011055383A3 WO 2011055383 A3 WO2011055383 A3 WO 2011055383A3 IN 2010000719 W IN2010000719 W IN 2010000719W WO 2011055383 A3 WO2011055383 A3 WO 2011055383A3
Authority
WO
WIPO (PCT)
Prior art keywords
dyslexia
performance
improve
intranasal delivery
children suffering
Prior art date
Application number
PCT/IN2010/000719
Other languages
French (fr)
Other versions
WO2011055383A2 (en
Inventor
Ambikanandan Rajnarayan Misra
Narendra Ishwarlal Gandhi
Mannalal Ramgopal Bajaj
Bharat Babulal Shah
Rajan Shantaram Samant
Hemal Rana
Original Assignee
Lyka Labs Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lyka Labs Limited filed Critical Lyka Labs Limited
Publication of WO2011055383A2 publication Critical patent/WO2011055383A2/en
Publication of WO2011055383A3 publication Critical patent/WO2011055383A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a pharmaceutical composition comprising therapeutically effective amount of stimulants, anti-motion drugs and nootropics, either alone or in combination, administered through, oral, intranasal or intravenous, for the treatment and/or management of dyslexia.
PCT/IN2010/000719 2009-11-06 2010-11-01 Intranasal delivery to improve the performance of children suffering from dyslexia WO2011055383A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2576MU2009 2009-11-06
IN2576/MUM/2009 2009-11-06

Publications (2)

Publication Number Publication Date
WO2011055383A2 WO2011055383A2 (en) 2011-05-12
WO2011055383A3 true WO2011055383A3 (en) 2011-06-30

Family

ID=43836534

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000719 WO2011055383A2 (en) 2009-11-06 2010-11-01 Intranasal delivery to improve the performance of children suffering from dyslexia

Country Status (1)

Country Link
WO (1) WO2011055383A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014152385A2 (en) * 2013-03-15 2014-09-25 Glia, Llc Cranial delivery of pharmaceuticals
CN104739796B (en) * 2013-12-27 2017-09-22 重庆润泽医药有限公司 A kind of Oxiracetam tablet and preparation method thereof
CN106389349A (en) * 2015-07-30 2017-02-15 重庆东泽医药科技发展有限公司 L-oxiracetam freeze drying powder for injection, and preparation method thereof
CN107536809A (en) * 2016-06-28 2018-01-05 重庆润泽医药有限公司 (S) preparation method of the pyrrolidine acetamide freeze-dried powder of 4 hydroxyl, 2 oxo 1
CN107550868A (en) * 2016-07-01 2018-01-09 重庆润泽医药有限公司 (S) preparation method of-Esomeprazole freeze-dried powder
CN109793734A (en) * 2019-03-06 2019-05-24 湘北威尔曼制药股份有限公司 Composition containing modafinil is used to treat the application of depression
CN113499311B (en) * 2021-08-16 2022-05-20 沈阳药科大学 Vinpocetine nano-emulsion for nose and preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067986A1 (en) * 2002-10-04 2004-04-08 Nathan Sassover Neuro-degenerative inhibitor, neuro-endocrine modulator, and neuro-cerebral metabolism enhancer
US20090176740A1 (en) * 2007-11-30 2009-07-09 Phillips Ii Dauglas James Treatment of neurological conditions by the co-administration of aniracetam and l-alpha glycerylphosphorylcholine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940485A (en) 1973-12-12 1976-02-24 Levinson Harold N Treatment and pre-treatment of dysmetric dyslexia by improving sequential scanning and ocular fixation abilities and therapeutic compounds
RU2212890C2 (en) 2001-12-24 2003-09-27 Закрытое акционерное общество "Брынцалов-А" Infusion solution "bravinton" for improvement of cerebral circulation
US7576133B2 (en) 2002-03-11 2009-08-18 Carl Henry Lawyer Methods and compositions for nasal administration of modafinil
RU2262931C2 (en) 2003-11-03 2005-10-27 Закрытое Акционерное Общество "Канонфарма Продакшн" Pharmaceutical composition possessing cerebrovasodilating and nootropic activity
EP1870097A1 (en) 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067986A1 (en) * 2002-10-04 2004-04-08 Nathan Sassover Neuro-degenerative inhibitor, neuro-endocrine modulator, and neuro-cerebral metabolism enhancer
US20090176740A1 (en) * 2007-11-30 2009-07-09 Phillips Ii Dauglas James Treatment of neurological conditions by the co-administration of aniracetam and l-alpha glycerylphosphorylcholine

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
"Methylphenidate (Ritalin) as a treatment for reading disability", NEDERLANDS TIJDSCHRIFT VOOR GENEESKUNDE, BOHN STAFLEU VAN LOGHUM, NL, vol. 125, no. 41, 1 January 1981 (1981-01-01), pages 1692, XP009147228, ISSN: 0028-2162 *
CONNERS C K ET AL: "Piracetam: Effects on reading achievement and evoked potentials in dyslexics", PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, ELSEVIER, US, vol. 27, no. 3, 1 July 1987 (1987-07-01), pages 589, XP023779535, ISSN: 0091-3057, [retrieved on 19870701], DOI: DOI:10.1016/0091-3057(87)90382-0 *
FEHLING JOSS C: "Influence of dyslexic factors by pyritinol hydrochloride. A long term, double blind study", CLINICAL TRIALS JOURNAL, ELSEVIER, AMSTERDAM, NL, vol. 11, no. 4, 1 January 1974 (1974-01-01), pages 123 - 133, XP009147226, ISSN: 0009-9325 *
FRANK J ET AL: "Dysmetric dyslexia and dyspraxia: hypothesis and study", JOURNAL OF AMERICAN ACADEMY OF CHILD & ADOLESCENT PSYCHIATRY,, vol. 12, no. 4, 1 January 1973 (1973-01-01), pages 690 - 701, XP009147227, ISSN: 0002-7138 *
LEVINSON H N: "DRAMATIC FAVORABLE RESPONSES OF CHILDREN WITH LEARNING DISABILITIESOR DYSLEXIA AND ATTENTION DEFICIT DISORDER TO ANTIMOTION SICKNESS MEDICATIONS: FOUR CASE REPORTS", PERCEPTUAL AND MOTOR SKILLS, MISSOULA, MT, US, vol. 73, 1 December 1991 (1991-12-01), pages 723 - 738, XP000937845, ISSN: 0031-5125 *
WILSHER C ET AL: "Piracetam as an aid to learning in dyslexia. Preliminary report", PSYCHOPHARMACOLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 65, no. 1, 1 September 1979 (1979-09-01), pages 107 - 109, XP009147224, ISSN: 0033-3158 *
WILSHER C R ET AL: "Piracetam and dyslexia: effects on reading tests", JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, WILLIAMS AND WILKINS, US, vol. 7, no. 4, 1 August 1987 (1987-08-01), pages 230 - 237, XP009147230, ISSN: 0271-0749 *
ZAVADENKO N N ET AL: "Dyslexia: clinical, neurophysiological and neuropsychological manifestations during the treatment with nootropil", ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S.S. KORSAKOVA, MINISTERSTVO ZDRAVOOKHRANENIIA I MEDITSINSKO, vol. 109, no. 5, 1 January 2009 (2009-01-01), pages 36 - 42, XP009147229, ISSN: 1997-7298 *

Also Published As

Publication number Publication date
WO2011055383A2 (en) 2011-05-12

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