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WO2010012004A3 - Monoclonal antibodies specific for pathological amyoid aggregates common to amyloids formed from proteins of differing sequence - Google Patents

Monoclonal antibodies specific for pathological amyoid aggregates common to amyloids formed from proteins of differing sequence Download PDF

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Publication number
WO2010012004A3
WO2010012004A3 PCT/US2009/051880 US2009051880W WO2010012004A3 WO 2010012004 A3 WO2010012004 A3 WO 2010012004A3 US 2009051880 W US2009051880 W US 2009051880W WO 2010012004 A3 WO2010012004 A3 WO 2010012004A3
Authority
WO
WIPO (PCT)
Prior art keywords
monoclonal antibodies
disease
alzheimer
amyoid
pathological
Prior art date
Application number
PCT/US2009/051880
Other languages
French (fr)
Other versions
WO2010012004A2 (en
Inventor
Charles G. Glabe
Rakez Kayed
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Priority to US13/055,908 priority Critical patent/US20110200609A1/en
Publication of WO2010012004A2 publication Critical patent/WO2010012004A2/en
Publication of WO2010012004A3 publication Critical patent/WO2010012004A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Monoclonal antibody compositions, methods of production and use. The monoclonal antibodies are specific to conformational epitope(s) of a prefibrillar aggregate(s) which contribute to amyloid fibril formation in human or animal subjects who suffer from amyloid diseases (e.g., Alzheimer's Disease) and the hybridomas and monoclonal antibodies produced therefrom. The monoclonal antibodies are useable for immunization of human or animal subjects against Alzheimer's Disease or other amyloid diseases and/or for the diagnosis or detection of Alzheimer's Disease or other amyloid diseases. The monoclonal antibodies may be administered concomitantly or in combination with anti-inflammatory agents, such as gold or gold containing compounds, to decrease neural inflammation associated with amyloid diseases (e.g., Alzheimer's Disease).
PCT/US2009/051880 2002-09-12 2009-07-27 Monoclonal antibodies specific for pathological amyoid aggregates common to amyloids formed from proteins of differing sequence WO2010012004A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/055,908 US20110200609A1 (en) 2002-09-12 2009-07-27 Monoclonal antibodies specific for pathological amyloid aggregates common to amyloids formed from proteins of differing sequence

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8385308P 2008-07-25 2008-07-25
US61/083,853 2008-07-25

Publications (2)

Publication Number Publication Date
WO2010012004A2 WO2010012004A2 (en) 2010-01-28
WO2010012004A3 true WO2010012004A3 (en) 2010-05-20

Family

ID=41570902

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/051880 WO2010012004A2 (en) 2002-09-12 2009-07-27 Monoclonal antibodies specific for pathological amyoid aggregates common to amyloids formed from proteins of differing sequence

Country Status (1)

Country Link
WO (1) WO2010012004A2 (en)

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* Cited by examiner, † Cited by third party
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CN102124105A (en) 2008-02-08 2011-07-13 伊缪纳斯制药株式会社 Antibody capable of binding specifically to Abeta-oligomer, and use thereof
AU2009236583B2 (en) 2008-04-17 2015-07-16 Declion Holdings Llc Design and synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
US9085614B2 (en) 2008-08-01 2015-07-21 Immunas Pharma, Inc. Antibodies that specifically bind to Aβ oligomers and uses thereof
CN102459335B (en) 2009-04-17 2015-11-25 伊缪纳斯制药株式会社 Antibody of specific binding A beta oligomers and uses thereof
CN102574915B (en) 2009-08-06 2014-10-22 伊缪纳斯制药株式会社 Antibodies that specifically bind to A beta oligomers and use thereof
DK2462162T3 (en) 2009-08-06 2017-01-16 Immunas Pharma Inc Antibodies that specifically bind to A-beta oligomers and their use
EA022007B1 (en) 2009-09-11 2015-10-30 Пробиодруг Аг Heterocylcic derivatives as inhibitors of glutaminyl cyclase
US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
US9879080B2 (en) 2015-01-28 2018-01-30 Prothena Biosciences Limited Anti-transthyretin antibodies
US10633433B2 (en) 2015-01-28 2020-04-28 Prothena Biosciences Limited Anti-transthyretin antibodies
EP3461819B1 (en) 2017-09-29 2020-05-27 Probiodrug AG Inhibitors of glutaminyl cyclase
MX2020003041A (en) 2017-10-06 2020-10-05 Prothena Biosciences Ltd Anti-transthyretin antibodies.
MX2020005433A (en) 2017-11-29 2020-08-27 Prothena Biosciences Ltd Lyophilized formulation of a monoclonal antibody against transthyretin.
US12115141B2 (en) 2018-11-14 2024-10-15 University Of Kentucky Research Foundation Diagnosis of diabetes by detecting aggregated amylin in erythrocytes
US20220251518A1 (en) * 2019-07-08 2022-08-11 Terumo Kabushik Kaisha Hybridoma, method for making the same, monoclonal antibody, and method for making the same
WO2021035210A1 (en) * 2019-08-22 2021-02-25 The Regents Of The University Of California A single chain antibody that binds tau oligomers and inhibits seeding by pathological extracts from alzheimer's disease
CN115916347A (en) * 2020-04-21 2023-04-04 德克萨斯大学系统董事会 Antibodies to chitinase 3-like 1 and methods of use thereof
CN112540180B (en) * 2020-11-06 2022-03-29 华中科技大学 ELISA detection kit for detecting human amyloid-beta double-antibody sandwich
CN112881708B (en) * 2021-01-19 2022-03-25 华中科技大学 Colloidal gold immunochromatographic test paper for detecting human amyloid-beta and preparation thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004024090A2 (en) * 2002-09-12 2004-03-25 The Regents Of The University Of California Immunogens and corresponding antibodies specific for high molecular weight aggregation intermediates common to amyloids formed from proteins of differing sequence
WO2005025516A2 (en) * 2003-09-12 2005-03-24 The Regents Of The University Of California Monoclonal antibodies specific for conformational epitopes of prefibrillar aggregates

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004024090A2 (en) * 2002-09-12 2004-03-25 The Regents Of The University Of California Immunogens and corresponding antibodies specific for high molecular weight aggregation intermediates common to amyloids formed from proteins of differing sequence
WO2005025516A2 (en) * 2003-09-12 2005-03-24 The Regents Of The University Of California Monoclonal antibodies specific for conformational epitopes of prefibrillar aggregates

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
0'NUALLAIN B ET AL.: "Conformational Abs recognizing a generic amyloid fibril epitope.", PROC NATL ACAD SCI USA., vol. 99, no. 3, 5 February 2002 (2002-02-05), pages 1485 - 1490 *
BUCCIANTINI M ET AL.: "Prefibrillar amyloid protein aggregates share common features of cytotoxicity.", J BIOL CHEM., vol. 279, no. 30, 23 July 2004 (2004-07-23), pages 31374 - 31382 *
GLABE CG.: "Conformation-dependent antibodies target diseases of protein misfolding.", TRENDS BIOCHEM SCI., vol. 29, no. 10, October 2004 (2004-10-01), pages 542 - 547 *

Also Published As

Publication number Publication date
WO2010012004A2 (en) 2010-01-28

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