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WO2010046713A3 - Methods for preparing heterocyclic rings - Google Patents

Methods for preparing heterocyclic rings Download PDF

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Publication number
WO2010046713A3
WO2010046713A3 PCT/GB2009/051435 GB2009051435W WO2010046713A3 WO 2010046713 A3 WO2010046713 A3 WO 2010046713A3 GB 2009051435 W GB2009051435 W GB 2009051435W WO 2010046713 A3 WO2010046713 A3 WO 2010046713A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
heterocyclic rings
preparing heterocyclic
preparing
carbon
Prior art date
Application number
PCT/GB2009/051435
Other languages
French (fr)
Other versions
WO2010046713A2 (en
WO2010046713A8 (en
Inventor
Christopher Joseph Schofield
Refaat B. Hamed
Edward Timothy Batchelar
Christian Ducho
Original Assignee
Isis Innovation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation Limited filed Critical Isis Innovation Limited
Publication of WO2010046713A2 publication Critical patent/WO2010046713A2/en
Publication of WO2010046713A3 publication Critical patent/WO2010046713A3/en
Publication of WO2010046713A8 publication Critical patent/WO2010046713A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A process for preparing an enantiomerically enriched compound containing a substituted heterocyclic ring, said process comprising a carbon-carbon bond formation reaction in the presence of a crotonase superfamily protein or a homolog or variant thereof.
PCT/GB2009/051435 2008-10-24 2009-10-23 Methods for preparing heterocyclic rings WO2010046713A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0819563A GB0819563D0 (en) 2008-10-24 2008-10-24 Methods for preparing heterocyclic rings
GB0819563.8 2008-10-24

Publications (3)

Publication Number Publication Date
WO2010046713A2 WO2010046713A2 (en) 2010-04-29
WO2010046713A3 true WO2010046713A3 (en) 2010-08-26
WO2010046713A8 WO2010046713A8 (en) 2010-09-23

Family

ID=40133796

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/051435 WO2010046713A2 (en) 2008-10-24 2009-10-23 Methods for preparing heterocyclic rings

Country Status (2)

Country Link
GB (1) GB0819563D0 (en)
WO (1) WO2010046713A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2376619A4 (en) 2008-12-15 2012-07-04 Greenlight Biosciences Inc Methods for control of flux in metabolic pathways
US8956833B2 (en) 2010-05-07 2015-02-17 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through enzyme relocation
EP3219796B1 (en) 2010-08-31 2020-10-07 GreenLight Biosciences, Inc. Methods for control of flux in metabolic pathways through protease manipulation
CN104093848A (en) 2011-09-09 2014-10-08 绿光生物科学公司 Cell-free preparation of carbapenems
JP6483687B2 (en) 2013-08-05 2019-03-13 グリーンライト バイオサイエンシーズ インコーポレーテッドＧｒｅｅｎｌｉｇｈｔ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． Engineered proteins with protease cleavage sites
EP3277808A4 (en) 2015-03-30 2019-05-22 Greenlight Biosciences, Inc. Cell-free production of ribonucleic acid
CN118667900A (en) 2016-04-06 2024-09-20 绿光生物科技股份有限公司 Cell-free ribonucleic acid production
JP7186167B2 (en) 2017-01-06 2022-12-08 グリーンライト バイオサイエンシーズ インコーポレーテッド Cell-free production of sugar
AR113764A1 (en) 2017-10-11 2020-06-10 Greenlight Biosciences Inc METHODS AND COMPOSITIONS FOR THE PRODUCTION OF NUCLEOSIDE TRIPHOSPHATE AND RIBONUCLEIC ACID

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
BATCHELAR ET AL: "Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 47, 29 October 2008 (2008-10-29), pages 9322 - 9325, XP002586942 *
DATABASE Geneseq [online] 15 July 2004 (2004-07-15), "Streptomyces cattleya NRRL 8057 orfl protein", XP002587036, retrieved from EBI Database accession no. ADO51702 *
DATABASE UniProt [online] 1 November 1999 (1999-11-01), "SubName: Full = CarB", XP002587037, retrieved from EBI Database accession no. Q9XB60 *
DATABASE UniProt [online] 1 October 2002 (2002-10-01), "SubName: Full = CpmB protein involved in carbapenem biosynthesis", XP002587038, retrieved from EBI Database accession no. Q8KM12 *
DUCHO ET AL: "Arbeiten zur Biosynthese von Carbapenem-Antibiotika; Chemiedozententagung; 11-14 March, 2007, Martin-Luther-Universität, Halle-Wittenberg, Germany", 2007, pages 19, XP002587046, Retrieved from the Internet <URL:http://cdt2007.chemie.uni-halle.de/Download/Prog_ChemDoz_2007.pdf> [retrieved on 20100615] *
DUCHO ET AL: "Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 7, 11 May 2009 (2009-05-11), pages 2770 - 2779, XP002586944 *
GERRATANA ET AL: "Carboxymethylproline synthase from Pectobacterium carotorova: A multifaceted member of the crotonase superfamily", BIOCHEMISTRY, vol. 43, 2004, pages 15936 - 15945, XP002586982 *
HAMED ET AL: "Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline", CHEMBIOCHEM, vol. 10, 17 December 2008 (2008-12-17), pages 246 - 250, XP002586943 *
HAMED ET AL: "Mechanisms and structures of crotonase superfamily enzymes - How nature controls enolate and oxyanion reactivity", CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 65, August 2008 (2008-08-01), pages 2507 - 2527, XP019619983 *
SLEEMAN ET AL: "Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, 2004, pages 6730 - 6736, XP002586940 *
SLEEMAN ET AL: "Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamnily catalyzing the first step in carbapenem biosynthesis", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, 2005, pages 34956 - 34965, XP002586941 *
SORENSEN ET AL: "Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylrpoline synthase (CarB) - implications for carbapenem biosynthesis", CHEMICAL COMMUNICATIONS, 2005, pages 1 - 4, XP002587035 *

Also Published As

Publication number Publication date
WO2010046713A2 (en) 2010-04-29
GB0819563D0 (en) 2008-12-03
WO2010046713A8 (en) 2010-09-23

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