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WO2009090548A3 - 3-azabicyclo [3.1.0] hexane derivatives as vanilloid receptor ligands - Google Patents

3-azabicyclo [3.1.0] hexane derivatives as vanilloid receptor ligands Download PDF

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Publication number
WO2009090548A3
WO2009090548A3 PCT/IB2009/000075 IB2009000075W WO2009090548A3 WO 2009090548 A3 WO2009090548 A3 WO 2009090548A3 IB 2009000075 W IB2009000075 W IB 2009000075W WO 2009090548 A3 WO2009090548 A3 WO 2009090548A3
Authority
WO
WIPO (PCT)
Prior art keywords
azabicyclo
vanilloid receptor
receptor ligands
hexane derivatives
vanilloid
Prior art date
Application number
PCT/IB2009/000075
Other languages
French (fr)
Other versions
WO2009090548A2 (en
Inventor
Laxmikant Atmaram Gharat
Lakshminarayana Narayana
Neelima Khairatkar-Joshi
Vidya G. Kattige
Original Assignee
Glenmark Pharmaceuticals, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals, S.A. filed Critical Glenmark Pharmaceuticals, S.A.
Publication of WO2009090548A2 publication Critical patent/WO2009090548A2/en
Publication of WO2009090548A3 publication Critical patent/WO2009090548A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to 3-azabicyclo[3.1.0]hexane derivatives, which are useful as vanilloid receptor (VR) ligands, methods of treating diseases, conditions and/or disorders modulated by vanilloid receptors with them, and processes for preparing them.
PCT/IB2009/000075 2008-01-17 2009-01-16 3-azabicyclo [3.1.0] hexane derivatives as vanilloid receptor ligands WO2009090548A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN125MU2008 2008-01-17
IN125/MUM/2008 2008-01-17
US2504208P 2008-01-31 2008-01-31
US61/025,042 2008-01-31

Publications (2)

Publication Number Publication Date
WO2009090548A2 WO2009090548A2 (en) 2009-07-23
WO2009090548A3 true WO2009090548A3 (en) 2010-11-04

Family

ID=40885715

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/000075 WO2009090548A2 (en) 2008-01-17 2009-01-16 3-azabicyclo [3.1.0] hexane derivatives as vanilloid receptor ligands

Country Status (1)

Country Link
WO (1) WO2009090548A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
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FR2945533B1 (en) * 2009-05-12 2011-05-27 Sanofi Aventis CYCLOPENTA® C! PYRROLYL-ALKYLCARBAMATE DERIVATIVES OF 5-CHAIN HETEROCYCLES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
MY177250A (en) 2010-06-30 2020-09-10 Fujifilm Corp Novel nicotinamide derivative or salt thereof
US9133116B2 (en) 2010-09-28 2015-09-15 Panacea Biotec Ltd. Bicyclic compounds
NO2799431T3 (en) 2011-12-28 2018-06-23
CL2012003253A1 (en) * 2012-11-22 2013-01-11 Univ Concepcion Compounds derived from 1,3,4-thiadiazole alkylamides and chalconas, trpv-1 receptor antagonists; use of compounds to treat chronic pain.
JP5934658B2 (en) * 2013-01-29 2016-06-15 Ｊｘエネルギー株式会社 IMIDE-UREA COMPOUND AND PROCESS FOR PRODUCING THE SAME, GREASE THINNER, AND GREASE COMPOSITION
KR101556318B1 (en) * 2013-05-15 2015-10-01 한국과학기술연구원 Novel 6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane compounds as calcium channel inhibitors
CN104311491A (en) * 2014-09-15 2015-01-28 湖南华腾制药有限公司 Preparation method of benzimidazole derivative
JP6994061B2 (en) 2019-02-15 2022-01-14 ノバルティス アーゲー Preparation of 4- (7-hydroxy-2-isopropyl-4-oxo-4H-quinazoline-3-yl) -benzonitrile
TW202045179A (en) 2019-02-15 2020-12-16 瑞士商諾華公司 Methods for treating ocular surface pain
RU2755206C1 (en) 2020-05-20 2021-09-14 Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) Agent with prolonged analgesic action and medicinal product based thereon
EP4232016A4 (en) * 2020-10-26 2024-04-17 University Of North Dakota Use of small molecule fak activators to promote mucosal healing
CN114957087A (en) * 2022-04-13 2022-08-30 湖南复瑞生物医药技术有限责任公司 Preparation method of intermediate of palovaried

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001036408A1 (en) * 1999-11-15 2001-05-25 New Pharma Research Sweden Ab Compounds with antibacterial and antiparasitic properties
WO2004033451A1 (en) * 2002-10-09 2004-04-22 Pharmacia & Upjohn Company Llc Antimicrobial [3.1.0] bicyclic oxazolidinone derivatives
WO2008010061A2 (en) * 2006-07-17 2008-01-24 Glenmark Pharmaceuticals S.A. 3-azabicyclo [3.1.0] hexane vanilloid receptor ligands, pharmaceutical compositions containing them, and processes for their preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001036408A1 (en) * 1999-11-15 2001-05-25 New Pharma Research Sweden Ab Compounds with antibacterial and antiparasitic properties
WO2004033451A1 (en) * 2002-10-09 2004-04-22 Pharmacia & Upjohn Company Llc Antimicrobial [3.1.0] bicyclic oxazolidinone derivatives
WO2008010061A2 (en) * 2006-07-17 2008-01-24 Glenmark Pharmaceuticals S.A. 3-azabicyclo [3.1.0] hexane vanilloid receptor ligands, pharmaceutical compositions containing them, and processes for their preparation

Also Published As

Publication number Publication date
WO2009090548A2 (en) 2009-07-23

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