WO2009076621A1 - High resolution structures of acidic mammalian chitinases and uses thereof - Google Patents

Abstract

High resolution structures of acidic mammalian chitinase (AMCase) are disclosed. The structures disclosed herein enable selection of, and structure-based rational drug design of, agents that modulate, e.g., antagonize, AMCase activity. Thus, crystal compositions, methods of selecting and/or designing agents, e.g., antagonists, of AMCase, and computer and software programs are disclosed.

Description

W2025-7029WO / AM102903-PCT

HIGH RESOLUTION STRUCTURES OF ACIDIC MAMMALIAN CHITINASES AND USES THEREOF

RELATED APPLICATIONS This application claims the benefit of U.S. Provisional Application No.

61/007,826, filed December 13, 2007, which is incorporated herein by reference in its entirety.

BACKGROUND Chitins, a polymer of Φ-1 , 4-N-acetyl-glucosamine (GIcNAc), are abundantly produced in nature in the exoskeleton of crustaceans and insects, the sheath of nematodes, the cell wall of fungi, and other marine organisms, parasites, and pathogens; but not by mammals. Chitin is degraded by chitinases (EC 3.2.1.14) that belong to members of the glycohydrolase family 18. This family is characterized by an eight fold I/Φ barrel structure and includes bacterial, as well as plant chitinases. Due to the lack of chitin in mammalian bodies, it has been generally assumed that chitinases are not present in mammals. Recent studies, however, have identified chitinases and chitinase-like proteins (CLPs) belonging to the glycohydrolase family 18 in mice and human, including, acidic mammalian chitinase (AMCase), chitinase 3-like-l (CHI3L1), chitotriosidase, YKL-39, YmI, oviduct-specific glycoprotein, and stabilin-1 -interacting chitinase-like protein (Hakala, et al, J. Biol. Chem., 268:25803-25810, 1993; Boot, et al, J. Biol. Chem., 270:26252-26256, 1995; Hu, et al, J. Biol. Chem., 271:19415-19420, 1996; Jin, et al, Genomics, 54:316-322, 1998; Boot, et al, J. Biol. Chem., 276:6770-6778, 2001; Buhi, W. C, Reproduction, 123:355-362, 2002; Kzhshkowska, et al, Blood, 107:3221- 3228, 2006; and Chang, et al, J. Biol. Chem., 276:17497-17506, 2001). Chitotriosidase and AMCase possess chitinase enzymatic activity, whereas other currently identified mammalian chitinases, including CLPs, do not possess this activity (Chang, et al, J. Biol. Chem., 276:17497-17506, 2001). The consensus catalytic site in enzymatically active chitinases is DGXDXDXE (SEQ ID NO: 6) on strand M. W2025-7029WO / AM102903-PCT

The prototypic chitinase, AMCase, catalyses the hydrolysis of artificial chitin-like substrates. It is unique among mammalian enzymes in that it has an acidic pH optimum. For example, AMCase catalyzes the conversion of chitin to N-acetyl-D-glucosamine. AMCase has been shown to be expressed predominately in the gastrointestinal tract, particularly the stomach, and to a lesser extent in the lung and is thought to play a role in digestion or possibly anti-parasitic defense mechanism.

AMCase is a secreted enzyme about 52.2 kD encoded by chromosome Ip 13.1- p21.3 (Boot, et al, J. Biol. Chem., 270:26252-26256, 1995; Saito A., et al, Gene, 239:325-331, 1999). Optimum AMCase activity is seen at pH 4-5, and it is typically found in stomach, salivary gland, and lung. AMCase is induced during T_H2 inflammation through an IL- 13 -dependent mechanism (Elias J. A., et al, J. Allergy Clin. Immunol, 116:497-500, 2005; Elias J. A., et al, J. Clin. Invest., 111:291-297, 2003). Moreover, the AMCase mRNA is significantly increased in an animal model of asthma compared to control, non-asthmatic animals (Zhu Z., et al., Science, 304:1678-1682, 2004). The mRNA encoding AMCase protein is elevated by intrathecal ovalbumin challenge or direct pulmonary instillation of IL- 13, and blocking binding of IL- 13 to the IL-13 receptor inhibits AMCase expression (Zhu Z., et al., Science, 304:1678-1682, 2004). AMCase neutralization has been shown to reduce asthmatic pathology in animal models; for example, lowered BAL inflammation has been observed in a mouse asthma model and reduced airway hyperactivity and dynamic compliance has been detected in OVA models in response to AMCase inhibition (WO 2004/092404).

Given the important biological activities of chitinases in normal and inflammatory conditions, the need exists for structural information on chitinase family members, such as human AMCase, that would help on the screening and/or design of modulators of human AMCase activity.

SUMMARY

High resolution structures of acidic mammalian chitinase (AMCase) are disclosed. In embodiments, three dimensional structures of uncomplexed (also referred to herein as "apo") and ligand-bound forms of the catalytic domain of human AMCase have been determined. For example, the high resolution structure of the catalytic domain W2025-7029WO / AM102903-PCT

of human AMCase complexed with the AMCase antagonist, methylallosamidin, has been determined. The structures disclosed herein enable the identification and/or design of agents that modulate, e.g., antagonize, AMCase activity. Thus, crystal compositions, methods of selecting and/or designing agents, e.g., antagonists, of AMCase, and computer and software programs are disclosed. The agents identified by the methods disclosed herein can be used to treat or prevent chitinase-associated disorders or conditions, such as inflammatory and respiratory disorders (e.g., asthma, chronic obstructive pulmonary disease (COPD), and emphysema).

Accordingly, in one aspect, the invention features a crystallized AMCase, e.g., a human AMCase polypeptide or fragment thereof.

In a related aspect, the invention features a crystallized AMCase-ligand complex that includes an AMCase (e.g., a human AMCase polypeptide or fragment thereof) and a ligand, e.g., an antagonist, of the AMCase.

In yet another aspect, the invention features a method that includes using a three- dimensional model of an AMCase to design an agent that binds the AMCase.

In yet another aspect, the invention features a method that includes using a three- dimensional model of an AMCase to identify (e.g., select and/or screen for) an agent that binds the AMCase.

In another aspect, the invention features a method that includes using a three- dimensional model of a complex including an AMCase to design an agent that binds the AMCase.

In a further aspect, the invention features a method that includes using a three- dimensional model of an AMCase-ligand complex to identify (e.g., select and/or screen for) an agent that binds the AMCase. In embodiments, the AMCase in the compositions and methods disclosed herein includes (or consists essentially of) a chitinase catalytic domain, a flexible linker and/or a chitin-binding domain, or a combination thereof. For example, the AMCase includes (or consists essentially of) the amino acid sequence from a mammalian (e.g., human) or non- mammalian AMCase; for example, the AMCase polypeptide can include (or consist essentially of) the amino acid sequence of residues about 1 to 389 of SEQ ID NO:2, or about residues 1 to 471 (full length), about 22 to 408 (chitinase catalytic domain), about W2025-7029WO / AM102903-PCT

409 to 435 (flexible linker), about 436 to 471 (chitin-binding domain) of SEQ ID NO:4; or an amino acid sequence substantially identical thereto (e.g., an amino acid sequence about 85%, 87%, 90%, 95%, 98% or more identical to the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:4), or a fragment thereof (e.g., a biologically active portion thereof as described herein); or an amino acid sequence encoded by a nucleic acid molecule comprising, or consisting essentially of, the nucleotide sequence of SEQ ID NO: 1 or SEQ ID NO:3, or a nucleotide sequence substantially identical thereto (e.g., a nucleotide sequence about 85%, 87%, 90%, 95%, 98% or more identical to the nucleotide sequence shown in SEQ ID NO: 1 or SEQ ID NO:3), or a fragment thereof. In other embodiments, the AMCase polypeptide is a fragment that includes (or consists essentially of) one or more of a chitinase catalytic domain, a flexible linker and/or a chitin-binding domain, or a combination thereof. In embodiments, the AMCase fragment includes at least 90, 100, 150, 200, 250, 300, 350, 400 or more contiguous amino acids of SEQ ID NO:2 or SEQ ID NO:4. In certain embodiments, the AMCase fragment includes one or more of ligand binding site, a chitin-binding site, and/or a catalytic site that includes the amino acid sequence DXXDXDXE (SEQ ID NO: 5). In other embodiments, the AMCase polypeptide or fragment thereof has up to 50, 40, 30, 20, 15, 10, 5, 3, 2, or 1 change(s), e.g., deletion(s), insertion(s), or substitution(s) (e.g., conservative substitution(s)) from the amino acid sequence of SEQ ID NO: 2 or 4. In embodiments, the change is located in a region that does not substantially alter the structure and/or activity of the AMCase polypeptide or fragment thereof. For example, one or more changes can be found at a site of the human AMCase that is exposed to a solvent, e.g., a site that has about 60 to 80%, 40 to 60%, 20 to 40%, 30 to 40%, 35 to 40%, 38 to 40%, 39 to 40%, or less than 20% access to the solvent. In other embodiments, the AMCase is crystallized, e.g., is capable of diffracting

X-rays to a resolution of at least about 3.7 A or less (e.g., about 3.6 A or less, about 3.5 A or less, about 3.2 A or less, about 3.0 A or less, about 2.7 A or less, about 2.4 A or less, about 2.3 A or less, about 2.2 A or less, about 2.1 A or less, about 2.0 A or less, about 1.9 A or less, about 1.8 A or less, about 1.7 A or less, about 1.6 A or less, about 1.5 A or less, or about 1.4 A or less). For example, a crystal of the human AMCase polypeptide can diffract X-rays to a resolution of from about 1.7 A to about 3.7 A (e.g., the crystal of the W2025-7029WO / AM102903-PCT

human AMCase polypeptide can diffract X-rays to about 2.7 A, about 3.5 A or about 3.6 A).

In certain embodiments, the crystal of the AMCase belongs to space group chosen from P2i or V2_\l_\l_\. In other embodiments, the crystal of AMCase belongs to space group P2i and has unit cell parameters chosen from one or more of: a=69.9 A, b=92.4 A, c=l 11.7 A, and α= γ=90° β= 95.9°, with four human AMCase polypeptides or four ligand- AMCase complexes in the asymmetric unit; or a=69.9 A, b=93.3 A, c=87.2 A, and α= γ=90° β= 106.92°, with three ligand- AMCase complexes in the asymmetric unit. In other embodiments, the crystal of the human AMCase-ligand complex belongs to space group V1{1_\1_\ and has unit cell parameters chosen from one or more of: a=63.69 A, b=89.29 A, c=126.69 A, and α=β=γ=90°, with two methylallosamidin-bound human AMCase polypeptides in the asymmetric unit; a=45.2 A, b=81.5 A, c=91.9 A, and α=β=γ=90°, with one complex of ligand-bound human AMCase in the asymmetric unit; or a=45.3 A, b=81.9 A, c=91.7 A, and α=β=γ=90°, with one ligand-bound human AMCase polypeptide in the asymmetric unit.

In yet another embodiment, the crystallized AMCase has a three-dimensional structure that includes the structural coordinates according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A, 1 A, or 0.5 A. In another embodiment, the crystallized AMCase has a three-dimensional structure that includes the structural coordinates of an atom chosen from one or more of amino acids: TYR-27, TRP-31, PHE-58, ILE-69, GLU-70, GLY-97, GLY-98, TRP-99, ASN-100, PHE-101, ASP-136, ASP-138, GLU-140, ALA-183, MET-210, TYR-212, ASP-213, TYR-267, ALA-295, LYS-296, GLU-297, ILE-300, MET-358, TRP-360, and/or LEU- 364 according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A, 1 A, or 0.5 A. In other embodiments, the crystallized

AMCase has a three-dimensional structure that includes the structural coordinates of an atom chosen from one or more of amino acids: THR-25, CYS-26, TYR-27, PHE-28, THR-29, ASN-30, TRP-31, ALA-32, GLN-33, TYR-34, ARG-35, ILE-55, TYR-56, ALA-57, PHE-58, ALA-59, GLY-60, THR-68, ILE-69, GLU-70, ASP-73, LEU-93, LEU-94, ALA-95, ILE-96, GLY-97, GLY-98, TRP-99, ASN-100, PHE-101, GLY-102, PHE-106, LEU-135, ASP-136, PHE-137, ASP-138, TRP-139, GLU-140, TYR-141, W2025-7029WO / AM102903-PCT

ARG-145, THR-181, ALA-182, ALA-183, VAL-184, ALA-185, ALA-186, ILE-207, HIS-208, VAL-209, MET-210, THR-211, TYR-212, ASP-213, LEU-214, HIS-215, TRP- 218, ASN-225, ILE-261, VAL-262, GLY-263, PHE-264, PRO-265, TYR-267, GLY-268, HIS-269, ASN-270, ALA-291, GLY-292, TYR-294, ALA-295, LYS-296, GLU-297, 5 SER-298, GLY-299, ILE-300, TRP-301, ALA-302, TYR-303, GLU-305, ALA-357, MET-358, VAL-359, TRP-360, ALA-361, ILE-362, ASP-363, LEU-364, and/or ASP- 365, according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A, 1 A, or 0.5 A. In other embodiments, the crystallized AMCase has a three-dimensional structure that includes the structural coordinates of o amino acid residues HIS-208, HIS-269 and ARG-145, according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A, 1 A, or 0.5 A, and one or more coordinate values from the aforesaid listed residues. Without wishing to be bound by theory, residues HIS-208, HIS-269 and ARG-145 are believed to alter (e.g., lower) the pH optimum of the enzyme, e.g., by influencing the pK_a of ASP1385 and/or GLU140. In other embodiments, the crystallized AMCase has a three- dimensional structure that includes the structural coordinates of amino acid residues HIS- 208, HIS-269, ARG-145, ASP138 and GLU140, according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A, 1 A, or 0.5 A, and one or more coordinate values from the aforesaid listed residues. 0 In embodiments, the methods disclosed herein include identifying (e.g., selecting) or designing the agent (e.g., one or more candidate agents) by one or more of: generating a three-dimensional model of the AMCase three-dimensional structure (e.g., utilizing the X-ray three-dimensional coordinates according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A, 1 A, or 0.5 A, to 5 generate a three-dimensional model of the AMCase three-dimensional structure); identifying the amino acid residues forming the ligand binding pocket of the AMCase ligand binding domain from the three-dimensional model in order to generate a three- dimensional representation of the ligand binding pocket of AMCase; evaluating an interaction between the three dimensional model or structure of AMCase and one or more0 candidate agents, e.g., by performing computer fitting analysis, the structure of the

AMCase, the AMCase-ligand complex or the one or more candidate agents; or altering, W2025-7029WO / AM102903-PCT

e.g., by rational drug design, the three-dimensional structure of the AMCase, the AMCase-ligand complex, or the one or more candidate agents disclosed herein, to thereby select or design the agent. In embodiments, the three dimensional structure of AMCase or the AMCase-ligand complex (e.g., the ligand binding pocket of AMCase) includes an atom chosen from one or more atoms of amino acids: TYR-27, TRP-31,

PHE-58, ILE-69, GLU-70, GLY-97, GLY-98, TRP-99, ASN-100, PHE-101, ASP-136, ASP-138, GLU-140, ALA-183, MET-210, TYR-212, ASP-213, TYR-267, ALA-295, LYS-296, GLU-297, ILE-300, MET-358, TRP-360, and/or LEU-364, according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A, 1 A, or 0.5 A. In other embodiments, the three dimensional structure of AMCase or the AMCase-ligand complex (e.g., the ligand binding pocket of AMCase) includes an atom chosen from one or more atoms of amino acids: THR-25, CYS -26, TYR-27, PHE-28, THR-29, ASN-30, TRP-31, ALA-32, GLN-33, TYR-34, ARG-35, ILE-55, TYR-56, ALA-57, PHE-58, ALA-59, GLY-60, THR-68, ILE-69, GLU-70, ASP- 73, LEU-93, LEU-94, ALA-95, ILE-96, GLY-97, GLY-98, TRP-99, ASN-100, PHE- 101, GLY-102, PHE-106, LEU-135, ASP-136, PHE-137, ASP-138, TRP-139, GLU-140, TYR-141, ARG-145, THR-181, ALA-182, ALA-183, VAL-184, ALA-185, ALA-186, ILE-207, HIS-208, VAL-209, MET-210, THR-211, TYR-212, ASP-213, LEU-214, HIS- 215, TRP-218, ASN-225, ILE-261, VAL-262, GLY-263, PHE-264, PRO-265, TYR-267, GLY-268, HIS-269, ASN-270, ALA-291, GLY-292, TYR-294, ALA-295, LYS-296, GLU-297, SER-298, GLY-299, ILE-300, TRP-301, ALA-302, TYR-303, GLU-305, ALA-357, MET-358, VAL-359, TRP-360, ALA-361, ILE-362, ASP-363, LEU-364, and/or ASP-365, according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A, 1 A, or 0.5 A. In other embodiments, the three-dimensional structure includes the structural coordinates of amino acid residues

HIS-208, HIS-269 and ARG-145, according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A, 1 A, or 0.5 A, and one or more coordinate values from the aforesaid listed residues. Without wishing to be bound by theory, residues HIS-208, HIS-269 and ARG-145 are believed to alter (e.g., lower) the pH optimum of the enzyme, e.g., by influencing the pKa of ASP138 and/or GLU140. In other embodiments, the three-dimensional structure that includes the structural W2025-7029WO / AM102903-PCT

coordinates of amino acid residues HIS-208, HIS-269, ARG-145, ASP138 and GLU140, according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A, 1 A, or 0.5 A, and one or more coordinate values from the aforesaid listed residues. In other embodiments, the methods disclosed herein include the step of contacting the candidate agent(s) with the AMCase, and evaluating, e.g., detecting, a change in one or more activities of the AMCase in the presence of the candidate agent(s), relative to a predetermined level, e.g., a control sample without the candidate agent(s). The contacting step can be effected in vitro (in cultured cells or a reconstituted system) or in vivo (e.g., by administering the candidate agent to a non-human subject). The contacting step(s) and/or the administration of the test compound can be repeated. In embodiments, the activities evaluated include one or more of: a change in binding (e.g., direct binding or ability to compete for binding with a known AMCase ligand), or an enzymatic activity of the AMCase. Exemplary known AMCase ligands that can be evaluated include methyallosamidin, allosamidin, glucoallosamindin-A or -B, methyl-N- demethylallosamidin, demethylallosamidin, didemethylallosamidin, styloguanidine, dipeptide cyclo-(L-Arg-D-Pro), (L-Arg-L-Pro), (D-Arg-D-Pro), riboflavin, antibody molecules (e.g., antibody molecule that bind to a catalytic or a chitinase-binding domain), or analogues thereof. In embodiments, the enzymatic activity of AMCase evaluate includes: (1) the ability to bind chitin and/or chi tin- like substrates; (2) the ability to catalyze the hydrolysis of chitin and/or chi tin-like substrates; (3) the ability to induce lung inflammation, e.g., airway hyperresponsiveness, in a subject (e.g., a non-human subject).

In in vivo embodiments, the method includes administering the candidate agent to a subject, e.g., a non-human animal (e.g., a sheep, a non-human primate (e.g., a cynomolgus monkey), or a rodent), and evaluating a change in one or more of parameters of a chitinase-associated disorder. For example, in asthmatic animal models, one or more of the following can be evaluated in the presence or absence of the candidate agent: (i) detecting a change in the number of inflammatory cells (e.g., eosinophils, macrophages, neutrophils) into the airways; (ii) measuring eotaxin levels; (iii) detecting in basophil histamine release; and/or (iv) detecting IgE titers. A change, e.g., a reduction, in the level W2025-7029WO / AM102903-PCT

of one or more of (i)-(iv) relative to a predetermined level (e.g., comparing before and after treatment) indicates that the candidate agent is effectively reducing airway eosinophilia in the subjects, and thus is a candidate for treating inflammatory pulmonary conditions (e.g., asthma, COPD and emphysema). The methods disclosed herein can additionally include one or more of the following steps: calculating a distance between an atom of the AMCase (e.g., the AMCase polypeptide or fragment thereof) and an atom of the agent; determining the interaction of the agent with the AMCase; comparing the interaction of the agent with the AMCase to an interaction of a second agent with the AMCase; selecting the agent via computer modeling; designing the candidate agent (e.g., de novo design or altering the three dimensional structure of a known compound, e.g., a known AMCase ligand as disclosed herein); obtaining the candidate agent, e.g., synthesizing the agent; detecting the ability of the agent to inhibit one or more AMCase activities (e.g., inhibit one or more of the AMCase enzymatic activities described herein). In embodiments, the method further includes one or more of: obtaining a supplemental crystalline complex that includes the AMCase and one or more candidate agents; determining the three-dimensional structure of the supplemental crystalline complex; evaluating, e.g., selecting, a second candidate agent by, e.g., performing rational drug design with the three-dimensional structure of the supplemental crystalline complex; contacting the second agent with the AMCase; and/or detecting the ability of the second agent to bind to or alter an activity of the AMCase. The method can further include one or more of: synthesizing the second agent; detecting an ability of the second agent to modulate, e.g., inhibit AMCase activity in vitro or in vivo (e.g., inhibit an AMCase enzymatic activity as described herein). In other embodiments, the agent designed or identified using the methods disclosed herein inhibits AMCase activity. For example, the agent can bind AMCase at a ligand binding site or a chitin-binding site, and/or interfere with an interaction between AMCase and the ligand or chitin. In certain embodiments, the agent preferentially displaces the beta-anomer form of the ligand, e.g., the chitin ligand. In embodiments, the ligand binding site bound by the agent is located on the chitinase catalytic domain, e.g., in proximity to the chitinase active site having a DGXDXDXE (SEQ ID NO: 6) motif, or W2025-7029WO / AM102903-PCT

one or more of: THR-25, CYS-26, TYR-27, PHE-28, THR-29, ASN-30, TRP-31, ALA- 32, GLN-33, TYR-34, ARG-35, ILE-55, TYR-56, ALA-57, PHE-58, ALA-59, GLY-60, THR-68, ILE-69, GLU-70, ASP-73, LEU-93, LEU-94, ALA-95, ILE-96, GLY-97, GLY- 98, TRP-99, ASN-100, PHE-101, GLY-102, PHE-106, LEU-135, ASP-136, PHE-137, ASP-138, TRP-139, GLU-140, TYR-141, ARG-145, THR-181, ALA-182, ALA-183, VAL-184, ALA-185, ALA-186, ILE-207, HIS-208, VAL-209, MET-210, THR-211, TYR-212, ASP-213, LEU-214, HIS-215, TRP-218, ASN-225, ILE-261, VAL-262, GLY- 263, PHE-264, PRO-265, TYR-267, GLY-268, HIS-269, ASN-270, ALA-291, GLY- 292, TYR-294, ALA-295, LYS-296, GLU-297, SER-298, GLY-299, ILE-300, TRP-301, ALA-302, TYR-303, GLU-305, ALA-357, MET-358, VAL-359, TRP-360, ALA-361, ILE-362, ASP-363, LEU-364, and/or ASP-365, according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A, 1 A, or 0.5 A. In other embodiments, the ligand binding site bound by the agent is located in proximity to one or more of: HIS-208, HIS-269, ARG-145, ASP138 and/or GLU140, according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A, 1 A, or 0.5 A, and one or more coordinate values from the aforesaid listed residues. Without wishing to be bound by theory, residues HIS-208, HIS-269 and ARG- 145 are believed to alter (e.g., lower) the pH optimum of the enzyme, e.g., by influencing the pKa of ASP138 and/or GLU140. In embodiments, the methods disclosed herein include providing a composition including an AMCase, or a AMCase -ligand complex, and/or crystallizing the composition to form a crystalline complex that includes the AMCase, or the AMCase- ligand complex (e.g., a crystallized form of AMCase or an AMCase complex as disclosed herein). The crystalline complex can diffract X-rays to a resolution of at least about 3.7 A (e.g., about 3.6 A or less, about 3.5 A or less, about 3.2 A or less, about 3.0 A or less, about 2.7 A or less, about 2.4 A or less, about 2.3 A or less, about 2.2 A or less, about 2.1 A or less, about 2.0 A or less, about 1.9 A or less, about 1.8 A or less, about 1.7 A or less, about 1.6 A or less, about 1.5 A or less, or about 1.4 A or less).

In another aspect, the invention features an agent designed or identified using the methods disclosed herein. W2025-7029WO / AM102903-PCT

In yet another aspect, the invention features a method for crystallizing an AMCase (e.g., a human AMCase polypeptide or fragment thereof). The method includes (i) providing the AMCase;

(ii) (optionally) providing a chitinase ligand (e.g., a chitinase inhibitor, such as allosamidin-like ligand or an analogue thereof);

(iii) mixing a solution of the AMCase, and (optionally) the chitinase ligand, in the presence of polyethylene glycol (e.g. PEG 2000, PEG 3350, PEG4000, PEG 6000), a salt (e.g., a sodium salt and/or ammonium salt), and a buffer (e.g. acetate, citrate, Tris buffer); and (iv) crystallizing the solution of step (iii), e.g., by sitting drop or hanging drop vapor diffusion to form a crystalline precipitate.

In embodiments, the solution of step (iii) is mixed with a crystallization buffer chosen from one or more of: 25% PEG4000, 0.1 M Sodium Acetate, 0.2 M Ammonium Sulfate; 20% PEG 3350, 0.2 M Ammonium Formate; 24.5% PEG 3350, 0.1 M bis-tris buffer at pH 6.5; 20% PEG 3350, 0.2 Ammonium Phosphate; 20% PEG 3350, 0.2 Ammonium Fluoride; or 20% PEG 3350, 0.2 di- Ammonium citrate.

In embodiments, the crystallization is performed at a temperature of from about 4°C to about 60⁰C (e.g., from about 10⁰C to about 45°C, such as at about 12°C, about 15°C, about 18°C, about 20⁰C, about 25°C, about 30⁰C, about 32°C, about 35°C, about 37°C).

In another aspect, the invention features a software system that includes instructions for causing a computer system to accept information relating to the structure of an AMCase (e.g., a human AMCase polypeptide or fragment thereof), accept information relating to a candidate agent, and determine binding characteristics of the candidate agent to the AMCase. The determination of binding characteristics can be based on the information relating to the structure of the AMCase, and the information relating to the candidate agent.

In yet another aspect, the invention features a computer program residing on a computer readable medium having a plurality of instructions stored thereon, which, when executed by one or more processors, cause the one or more processors to accept information relating to the structure of a complex comprising an AMCase, accept W2025-7029WO / AM102903-PCT

information relating to a candidate agent, and determine binding characteristics of the candidate agent to the AMCase. The determination of binding characteristics can be based on the information relating to the structure of the AMCase and the information relating to the candidate agent. In another aspect, the invention features a method that includes accepting information relating to the structure of an AMCase and modeling the binding characteristics of the AMCase with a candidate agent. The method can be implemented by a software system.

In yet another aspect, the invention features a computer program residing on a computer readable medium having a plurality of instructions stored thereon, which, when executed by one or more processors, cause the one or more processors to accept information relating to a structure of an AMCase and model the binding characteristics of the AMCase with a candidate agent.

In another aspect, the invention features a software system that includes instructions for causing a computer system to accept information relating to a structure of an AMCase and model the binding characteristics of the AMCase with a candidate agent.

In a further aspect, the invention features a method of modulating AMCase activity in a subject that includes: selecting or designing, e.g., using the methods described herein (e.g., by rational drug design), an agent that is capable of modulating AMCase activity and administering an effective amount of the agent to the subject, such that the AMCase activity is modulated.

In another aspect, the invention features a method of treating or preventing in a subject having, or at risk of having, a chitinase-associated disorder or condition that includes: selecting or designing, e.g., using the methods described herein (e.g., by rational drug design), an agent that is capable of affecting (e.g., inhibiting) AMCase activity and administering a therapeutically effective amount of the agent to a subject in need thereof.

In embodiments, the agent used in the methods disclosed herein, e.g., the therapeutic and prophylactic methods disclosed herein, inhibit one or more AMCase enzymatic activity in vivo (e.g., reduce, ameliorate, or cure one or more symptoms) of a chitinase-associated disorder or condition in a subject. Exemplary chitinase-associated W2025-7029WO / AM102903-PCT

disorders include inflammatory disorders (e.g., lung inflammation), respiratory disorders (e.g., asthma, including allergic and non-allergic asthma, chronic obstructive pulmonary disease (COPD), emphysema), as well as conditions involving airway inflammation, eosinophilia, interstitial lung disease, chronic obstructive lung disease, bronchitis, pneumonia, fibrotic disorders (e.g., cystic fibrosis, liver fibrosis, and pulmonary fibrosis); scleroderma; atopic disorders (e.g., atopic dermatitis, urticaria, eczema, allergic rhinitis, and allergic enterogastritis), and inflammatory bowel disease.

Other features and advantages of the invention will be apparent from the description, drawings and claims.

DESCRIPTION OF DRAWINGS

FIGs IA- IB depict the nucleotide and amino acid sequences of a truncated human AMCase polypeptide used for crystallization (SEQ ID NO:1 and SEQ ID NO: 2, respectively). This human AMCase sequence has a mutation at position 354 to replace a serine for a phenylalanine and a histidine tag at the C-terminal end. FIGs. 2A-2B depict the full length nucleotide and amino acid sequences, respectively, of an exemplary human acidic chitinase acidic isoform C precursor (SEQ ID NO:3 and SEQ ID NO:4, respectively). The AMCase amino acid sequence used for crystallization encompassed the catalytic domain of human AMCase located at about amino acids 22 to 408 of the amino acid sequence of FIG. 2A (SEQ ID NO:4). Amino acids 22 to 408 of the full length amino acid sequence shown in Figure 2B has some minor differences from the AMCase truncated sequence shown in Figure IB at 5 positions.

FIG. 3A illustrates a ribbon representation of human AMCase polypeptide bound with methyallosamidin. The location of the N-terminus and the C-terminus is indicated. FIG. 3B illustrates an electrostatic surface potential map of AMCase showing the active site cleft, in the same orientation as FIG. 3A. Positive and negative charge is depicted at +15.0 kT/e, respectively. The long negatively charged groove that accommodates chitin binding is visible.

FIG. 4 illustrates a 2Fo-Fc electron density map, contoured at 1.2 σ, showing methyallosamidin bound to human AMCase polypeptide, at a resolution of 1.7 A. W2025-7029WO / AM102903-PCT

FIG. 5 is a table summarizing the characteristics of the AMCase crystals disclosed herein, including crystallization conditions, space group and unit cell dimensions.

FIG. 6 is a summary of interactions between methylallosamidin and AMCase active site residues. FIG. 7A illustrates a ribbon diagram of the AMCase active site, depicting side chains of certain residues. ASP-136, ASP-138, GLU-140, ASP-213, and TRP-360 are highly conserved active site residues, ARG-145, HIS-208, and HIS-269 are residues specific to AMCase. Dotted lines indicate hydrogen bonds, with the distance in angstroms indicated. FIG. 7B illustrates ARG-145 in the context of the active site. ARG-145 affects substrate binding via a network of hydrogen bonds mediated by TRP-99, ASN-100, and GLU-140.

FIG. 8 illustrates a space-filled representation of AMCase molecules showing the crystal packing of Apo AMCase. The C-terminal end of one molecule binds in the active site cleft of the neighboring molecule.

FIG. 9 illustrates the modeled binding of the alpha-anomer vs the beta-anomer of a chitin fragment (chitopentose). This figure shows the structural basis of the preference for the beta-anomer of the substrate by AMCase. The terminal hydroxyl of the alpha- anomer, (labeled as alpha-chitopentose, terminal hydroxyl), makes an unfavorable electrostatic interaction with the -NH of the indole ring of Trp-218, and thus binding of the beta-anomer (labeled as beta-chitopentose, terminal hydroxyl) is energetically more favorable.

DETAILED DESCRIPTION In general, the present invention relates to human AMCase polypeptides, human

AMCase polypeptide/ligand complexes, crystals of human AMCase polypeptides, crystals of human AMCase polypeptide/ligand complexes, and related methods and software systems. In embodiments, the invention provides high resolution, three dimensional structures of uncomplexed and ligand-bound forms of the catalytic domain of human AMCase. For example, the high resolution structure of the catalytic domain of W2025-7029WO / AM102903-PCT

human AMCase complexed with the AMCase antagonist, methylallosamidin, has been determined.

The structures disclosed herein can be useful for designing or identifying inhibitors that can interact with human AMCase polypeptides. Structure-based modeling can allow the identification of an agent capable of interacting with AMCase, without the need to experimentally test a large variety of compounds in vivo or in vitro with the goal of identifying a candidate agent that can interact with AMCase. Such screening can be expensive and time-consuming. Modifications to a known agent that interacts with AMCase can be examined with structure based design to identify an agent with more desirable properties, such as tighter binding or greater selectivity for AMCase over other chitinases, without the need to prepare and test each modified agent.

Shown in FIG. 1A-1B is the nucleotide and amino acid sequence (SEQ ID NO:1 and SEQ ID NO:2, respectively) of a fragment of human AMCase polypeptide (human AMCase) that includes the catalytic domain of family 18 glycosylases The hexahistidine tag facilitated purification. Not present in the human AMCase polypeptide is a 21 amino acid signal sequence that is found at the N-terminus of the full-length human AMCase. FIG. 2 is a ribbon diagram illustrating the structure of methylallosamidin-bound human AMCase polypeptide (amino acid residues 22-400 of the catalytic domain of human AMCase). FIG. 3 is a 2Fo-Fc electron density map, depicting the high quality of the electron density for the methylallosamidin in the bound human AMCase. The coordinates of a crystal structure of the human AMCase polypeptide are provided in Table 1. The coordinates of a crystal structure of the methylallosamidin-bound human AMCase polypeptide are provided in Table 2.

AMCases belong to a family of chitinases of the glycohydrolase family 18. Recent studies have identified chitinases and chitinase-like proteins (CLPs) belonging to the glycohydrolase family 18 in mice, human and non-human primates. The members of the mammalian chitinases and CLPs include acidic mammalian chitinase (AMCase), chitinase 3-like-l (CHI3L1), chitotriosidase, YKL-39, YmI, oviduct-specific glycoprotein, and stabilin-1 -interacting chitinase-like protein (Hakala, et ah, J. Biol. Chem., 268:25803-25810, 1993; Boot, et ai, J. Biol. Chem., 270:26252-26256, 1995; Hu, et al, J. Biol. Chem., 271:19415-19420, 1996; Jin, et al, Genomics, 54:316-322, 1998; W2025-7029WO / AM102903-PCT

Boot, et al, J. Biol. Chem., 276:6770-6778, 2001; Buhi, W. C, Reproduction, 123:355- 362, 2002; Kzhshkowska, et al, Blood, 107:3221-3228, 2006; and Chang, et al, J. Biol Chem., 276:17497-17506, 2001). Chitotriosidase and AMCase possess chitinase enzymatic activity, whereas other currently identified mammalian chitinases, including CLPs, do not possess this activity (Chang, et al, J. Biol. Chem., 276:17497-17506,

2001). The consensus catalytic site in enzymatically active chitinases is DGXDXDXE (SEQ ID NO: 6) on strand M.

AMCase polypeptides or fragments can include one or more of the following domains: chitinase catalytic domain, a linker region, and/or a chi tin-binding domain, or regions substantially identical thereto.

As used herein, the term "chitinase catalytic domain" includes an amino acid sequence about 200 to 400, more typically about 300 to 400 amino acids in length (e.g., from about amino acid residues 1 to 401 of SEQ ID NO: 2, or about residues 22 to 408 of SEQ ID NO:4 and which typically includes a consensus catalytic site having the amino acid sequence DGXDXDXE (SEQ ID NO: 6); or an amino acid sequence substantially identical thereto (e.g., an amino acid sequence about 85%, 87%, 90%, 95%, 98% or more identical to the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:4), or a fragment thereof (e.g., a biologically active portion thereof as described herein); or an amino acid sequence encoded by a nucleic acid molecule comprising, or consisting essentially of, the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:3, or a nucleotide sequence substantially identical thereto (e.g., a nucleotide sequence about 85%, 87%, 90%, 95%, 98% or more identical to the nucleotide sequence shown in SEQ ID NO: 1 or SEQ ID NO: 3), or a fragment thereof.

An AMCase polypeptide can further include a "chitin-binding domain." A "chitin-binding domain" includes an amino acid sequence about 20 to 70, more typically about 40 to 50 amino acids in length and which has at least about 90% 95%, 99%, or 100% identity with amino acid residues 436 to 471 of SEQ ID NO:4.

An AMCase polypeptide can also include a linker region connecting the catalytic and chitinase-binding domains. In embodiments, the linker region can have an amino acid sequence about 10 to 30, 15 to 28 amino acid residues in length, and having an W2025-7029WO / AM102903-PCT

amino acid sequence identical or substantially identical to amino acids 409 to 435 of SEQ ID NO:4.

Particular AMCase polypeptides or fragments of the present invention have an amino acid sequence substantially identical to the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4. In the context of an amino acid sequence, the term "substantially identical" is used herein to refer to a first amino acid that contains a sufficient or minimum number of amino acid residues that are i) identical to, or ii) conservative substitutions of aligned amino acid residues in a second amino acid sequence such that the first and second amino acid sequences can have a common structural domain and/or common functional activity. For example, amino acid sequences that contain a common structural domain having at least about 85%, 90%. 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identity to SEQ ID NO:2 or SEQ ID NO:4 are termed substantially identical.

In the context of nucleotide sequence, the term "substantially identical" is used herein to refer to a first nucleic acid sequence that contains a sufficient or minimum number of nucleotides that are identical to aligned nucleotides in a second nucleic acid sequence such that the first and second nucleotide sequences encode a polypeptide having common functional activity, or encode a common structural polypeptide domain or a common functional polypeptide activity. For example, nucleotide sequences having at least about 85%, 90%. 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identity to SEQ ID NO:1 or 3 are termed substantially identical.

To determine the percent identity of two amino acid sequences, or of two nucleic acid sequences, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second amino acid or nucleic acid sequence for optimal alignment and non-homologous sequences can be disregarded for comparison purposes). In a preferred embodiment, the length of a reference sequence aligned for comparison purposes is at least 30%, preferably at least 40%, more preferably at least 50%, 60%, and even more preferably at least 70%, 80%, 90%, 100% of the length of the reference sequence. The amino acid residues or nucleotides at corresponding amino acid positions or nucleotide positions are then compared. When a position in the first sequence is occupied by the same amino acid residue or nucleotide as the W2025-7029WO / AM102903-PCT

corresponding position in the second sequence, then the molecules are identical at that position (as used herein amino acid or nucleic acid "identity" is equivalent to amino acid or nucleic acid "homology"). The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, which need to be introduced for optimal alignment of the two sequences.

The comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm. In a preferred embodiment, the percent identity between two amino acid sequences is determined using the Needleman and Wunsch ((1970) /. MoI. Biol. 48:444-453 ) algorithm which has been incorporated into the GAP program in the GCG software package (available at http://www.gcg.com), using either a Blossum 62 matrix or a PAM250 matrix, and a gap weight of 16, 14, 12, 10, 8, 6, or 4 and a length weight of 1, 2, 3, 4, 5, or 6. In yet another preferred embodiment, the percent identity between two nucleotide sequences is determined using the GAP program in the GCG software package (available at http://www.gcg.com), using a NWSgapdna.CMP matrix and a gap weight of 40, 50, 60, 70, or 80 and a length weight of 1, 2, 3, 4, 5, or 6. A particularly preferred set of parameters (and the one that should be used unless otherwise specified) are a Blossum 62 scoring matrix with a gap penalty of 12, a gap extend penalty of 4, and a frameshift gap penalty of 5.

The percent identity between two amino acid or nucleotide sequences can be determined using the algorithm of E. Meyers and W. Miller ((1989) CABIOS, 4: 11-17) which has been incorporated into the ALIGN program (version 2.0), using a PAM120 weight residue table, a gap length penalty of 12 and a gap penalty of 4. The nucleic acid and protein sequences described herein can be used as a "query sequence" to perform a search against public databases to, for example, identify other family members or related sequences. Such searches can be performed using the NBLAST and XBLAST programs (version 2.0) of Altschul, et al. (1990) /. MoI. Biol. 215:403-10. BLAST nucleotide searches can be performed with the NBLAST program, score = 100, wordlength = 12 to obtain nucleotide sequences homologous to pNC nucleic acid (SEQ ID NO: 1) molecules of the invention. BLAST protein searches can be W2025-7029WO / AM102903-PCT

performed with the XBLAST program, score = 50, wordlength = 3 to obtain amino acid sequences homologous to pNC (SEQ ID NO: 1) protein molecules of the invention. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al, (1997) Nucleic Acids Res. 25:3389-3402. When utilizing BLAST and Gapped BLAST programs, the default parameters of the respective programs (e.g., XBLAST and NBLAST) can be used. See http://www.ncbi.nlm.nih.gov.

Conservative substitutions are amino acid substitutions which are functionally or structurally equivalent to the substituted amino acid residue in terms of polarity, steric arrangement, or belonging to the same class (e.g., hydrophobic, acidic or basic) as the substituted residue. Classes of amino acid residues having similar side chains have been defined in the art. These classes include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), beta-branched side chains (e.g., threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine). Conservative substitutions include substitutions having an inconsequential effect on the three-dimensional structure of AMCase with respect to identification and design of agents that interact with AMCase. "About" and "approximately" shall generally mean an acceptable degree of error for the quantity measured given the nature or precision of the measurements. Typically, exemplary degrees of error are within 20 percent (%), preferably within 10%, and more preferably within 5% of a given value or range of values. In the context of an amino acid or nucleotide sequence, the term "about" refers to a sequence having up to 5, 4, 3, 2, or 1 more or less amino acid residues or nucleotides at the N- or C-terminus of the sequence specified.

As the agents identified using the methods described herein may modulate, e.g., inhibit, one or more chitinase -associated activities, they may be useful for developing novel therapeutic agents for chitinase-associated disorders, as described below. As used herein, an AMCase or a chitinase activity, biological or enzymatic activity of AMCase refers to an activity exerted by an AMCase polypeptide. An W2025-7029WO / AM102903-PCT

AMCase or chitinase activity can be determined in vivo or in vitro. In one embodiment, an AMCase activity is a direct activity, such as an association with an AMCase target molecule or binding partner, e.g., a target molecule or binding partner with which the AMCase binds or interacts in nature. In an exemplary embodiment, AMCase is an enzyme for a chitin-like substrate. For example, the AMCase proteins can have one or more of the following activities or properties: (1) has the ability to bind chitin and/or chitin-like substrates; (2) catalyzes the hydrolysis of chitin and/or chitin-like substrates; (3) has optimal catalytic properties in acidic pH; (4) is inhibited by a chitinase-like inhibitor, such as methylallosamidin, allosamidin, glucoallosamindin-A or -B, methyl-N- demethylallosamidin, demethylallosamidin, didemethylallosamidin, styloguanidine, dipeptide cyclo-(L-Arg-D-Pro) or (L-Arg-L-Pro), or (D-Arg-D-Pro), riboflavin; and/or (5) induces lung inflammation, e.g., airway hyperresponsiveness in a subject, e.g., asthmatic patients, particularly patients having allergic asthma.

Thus, the agents identified using the methods disclosed herein can act as novel therapeutic agents for detecting and/or treating chitinase-associated diseases, including, but not limited to, inflammatory disorders (e.g., lung inflammation), respiratory disorders (e.g., asthma, including allergic and non-allergic asthma, chronic obstructive pulmonary disease (COPD), emphysema), as well as conditions involving airway inflammation, eosinophilia, interstitial lung disease, chronic obstructive lung disease, bronchitis, pneumonia, fibrotic disorders (e.g., cystic fibrosis, liver fibrosis, and pulmonary fibrosis); scleroderma; atopic disorders (e.g., atopic dermatitis, urticaria, eczema, allergic rhinitis, and allergic enterogastritis), and inflammatory bowel disease.

An agent, e.g., an antagonist, that interacts with (e.g., binds) the AMCase polypeptide can be identified or designed by a method that includes using a representation of the polypeptide or a fragment of the polypeptide. Exemplary types of representations include the representations discussed herein. In some embodiments, the representation can be of an analog polypeptide or polypeptide fragment. A candidate agent that interacts with the representation can be designed or identified by performing computer fitting analysis of the candidate agent with the representation. In general, the agent, e.g., a candidate agent, includes a protein, polypeptide, peptide, nucleic acid

(including DNA or RNA), molecule, compound or drug. An agent can act as a ligand, W2025-7029WO / AM102903-PCT

substrate, inhibitor, activator, allosteric effector, or binding partner with an enzyme. An agent that interacts with a polypeptide (e.g., a human AMCase polypeptide) can interact transiently or stably with the polypeptide. The interaction can be mediated by any of the forces noted herein, including, for example, hydrogen bonding, electrostatic forces, hydrophobic interactions, and van der Waals interactions.

An active site is a region of a molecule or molecular complex that can interact or associate with an agent (including, without limitation, a protein, polypeptide, peptide, nucleic acid, including DNA or RNA, molecule, compound or drug). An active site may include, for example, the site of agent binding, as well as accessory binding sites adjacent or proximal to the actual site of binding that may affect activity upon interaction or association with a particular agent. The active site can include a site of ligand, e.g., inhibitor, binding. The inhibitor can inhibit either by direct interference with the actual site of substrate binding (i.e., by competing for substrate binding) or by indirectly affecting the steric conformation or charge potential, thereby preventing or reducing binding of substrate at the actual site of substrate binding.

Various aspects of the invention are described in further detail below.

AMCase Ligands

Ligands that interact with human AMCase polypeptides can inhibit or increase human AMCase activity. As an example, AMCase activity can be inhibited or reduced by an antagonist, such as allosamidin, methylallosamidin, glucoallosamindin-A or -B, methyl-N-demethylallosamidin, demethylallosamidin, didemethylallosamidin, styloguanidine, dipeptide cyclo-(L-Arg-D-Pro) or (L-Arg-L-Pro), or (D-Arg-D-Pro), riboflavinhuman, or an analog thereof.

Allosamidin-like ligands can have general formula (I)

W2025-7029WO / AM102903-PCT

(I) in which: one of Ri and R₂ is hydrogen, and the other is hydroxyl or C₁-C₄ alkoxy; one of R₃ and R₄ is hydrogen, and the other is hydroxyl or C₁-C₄ alkoxy; each of R₅ and Rio is, independently, hydrogen or C₁-C₃ alkyl; each of R₆ and Rn is, independently, Ci-C₆ alkyl; each Of R₇, R₁₂, and R₁3 is, independently, hydrogen; Ci-C₆ alkyl; C₁-C₄ haloalkyl; C₂-C₆ alkenyl; C₂-C₆ alkenyl; C₃-C₆ cycloalkyl, C₃-C₆ cycloalkenyl, heterocyclyl including from 3-6 atoms, phenyl, or heteroaryl including from 5-6 atoms, each of which is optionally substituted with one or more substituents; one of Rg and R₉ is hydrogen, and the other is hydroxyl or C₁-C₄ alkoxy;

X is O, NH, or S;

R ₁₄ is Ci-C₆ alkyl; and

Ri₅ is hydrogen or Ci-C₆ alkyl.

Embodiments can include one or more of the following features. Variables R₁, R₂, R₃, R4, Rs, and RQ

In some embodiments, each of Ri and R₃ can be hydrogen, and each of R₂ and R₄ can be, independently of one another, hydroxyl or C₁-C₄ alkoxy (e.g., OCH₃). In certain embodiments, each of Ri and R₃ can be hydrogen, and each of R₂ and R₄ can be hydroxyl. In some embodiments, each of Ri and R₄ can be hydrogen, and each of R₂ and R₃ can be, independently of one another, hydroxyl or C₁-C₄ alkoxy (e.g., OCH₃). In certain embodiments, each of Ri and R₄ can be hydrogen, and each of R₂ and R₃ can be hydroxyl.

In some embodiments, each of R₂ and R₃ can be hydrogen, and each of Ri and R₄ can be, independently of one another, hydroxyl or C₁-C₄ alkoxy (e.g., OCH₃). In certain W2025-7029WO / AM102903-PCT

embodiments, each of R₂ and R₃ can be hydrogen, and each of Ri and R₄ can be hydroxyl.

In some embodiments, each of R₂ and R₄ can be hydrogen, and each of Ri and R₃ can be, independently of one another, hydroxyl or C₁-C₄ alkoxy (e.g., OCH₃). In certain embodiments, each of R₂ and R₄ can be hydrogen, and each of Ri and R₃ can be hydroxyl.

In some embodiments, Rs is hydrogen, and R₉ is hydroxyl or C₁-C₄ alkoxy (e.g., OCH₃). In certain embodiments, Rg is hydrogen, and R₉ is hydroxyl.

In some embodiments, R₉ is hydrogen, and Rg is hydroxyl or C₁-C₄ alkoxy (e.g., OCH₃). In certain embodiments, R₉ is hydrogen, and Rg is hydroxyl.

Embodiments can include any combination of (i) definitions for variables R₁-R₄ as delineated above and (ii) definitions for variables Rg and R₉ as delineated above.

For example, in some embodiments, each of Ri, R₃, and Rg can be hydrogen, and each of R₂, R₄, and R₉ can be, independently of one another, hydroxyl or C₁-C₄ alkoxy (e.g., OCH₃). In certain embodiments, each of Ri, R₃, and Rg can be hydrogen, and each of R₂, R₄, and R₉ can be hydroxyl.

As another example, each of R₁, R₃, and R₉ can be hydrogen, and each of R₂, R₄, and Rg can be, independently of one another, hydroxyl or C₁-C₄ alkoxy (e.g., OCH₃). In certain embodiments, each of R₁, R₃, and R₉ can be hydrogen, and each of R₂, R₄, and Rg can be hydroxyl.

Variables R^ and R_m

In some embodiments, R₅ can be hydrogen or CH₃. In some embodiments, Rio can be hydrogen or CH₃. In certain embodiments, each of R₅ and Rio can be hydrogen. Variables R^ and Rr^

In some embodiments, R₆ can be CH₃ or CH₂CH₃ (e.g., CH₃). In other embodiments, R₅ can be straight or branched C₃-C₆ alkyl.

In some embodiments, Rn can be CH₃ or CH₂CH₃ (e.g., CH₃). In other embodiments, R₅ can be straight or branched C₃-C₆ alkyl. In certain embodiments, each of R₆ and Rn can be CH₃.

Variables R7, Rr?< and R^ W2025-7029WO / AM102903-PCT

In some embodiments, one (e.g., R₇), two (e.g., R₇ and R₁₂ or R₇ and R₁₃), or three of R₇, R₁₂, and R_i3 can be Ci-C₆ alkyl; Ci-C₄ haloalkyl; C₂-C₆ alkenyl; C₂-C₆ alkenyl; C₃- C₆ cycloalkyl, C₃-C₆ cycloalkenyl, heterocyclyl including from 3-6 atoms, phenyl, or heteroaryl including from 5-6 atoms, each of which can be optionally substitutedwith one or more substituents; and the others can be hydrogen.

In certain embodiments, R₇ can be Ci-C₆ alkyl; C₁-C₄ haloalkyl; C₂-C₆ alkenyl; C₂-C₆ alkenyl; C₃-C₆ cycloalkyl, C₃-C₆ cycloalkenyl, heterocyclyl including from 3-6 atoms, phenyl, or heteroaryl including from 5-6 atoms, each of which can be optionally substituted with one or more substituents. For example, R₇ can be Ci-C₆ (e.g., C₁-C₄) alkyl, e.g.., R₇ can be CH₃ or CH₂CH₃ (e.g., CH₃); or straight or branched C₃-C₆ alkyl. As another example, R₇ can be C₁-C₄ haloalkyl (e.g., CH₂F or CF₃). In certain embodiments, Ri₂ can be hydrogen. In certain embodiments, Ri₃ can be hydrogen. Variable X In some embodiments, X can be O.

In some embodiments, R₁₄ can be CH₃ or CH₂CH₃ (e.g., CH₃). In other embodiments, R₁₄ can be straight or branched C₃-C₆ alkyl.

In some embodiments, R₁₅ can be CH₃ or CH₂CH₃ (e.g., CH₃). In other embodiments, R₁₅ can be straight or branched C₃-C₆ alkyl.

In certain embodiments, R₁₄ can be CH₃, and R₁₅ can be CH₃ or CH₂CH₃ (e.g., CH₃); or straight or branched C₃-C₆ alkyl. In certain embodiments, each of R₁₄ and R₁₅ can be CH₃.

A subset of formula (I) compounds includes in which: • each of R₁, R₃, and R₈ can be hydrogen, and each of R₂, R₄, and R₉ can be, independently of one another, hydroxyl or C₁-C₄ alkoxy (e.g., OCH₃); and

• R₇ can be C_x-C₆ alkyl; C_x-C₄ haloalkyl; C₂-C₆ alkenyl; C₂-C₆ alkenyl; C₃- C₆ cycloalkyl, C₃-C₆ cycloalkenyl, heterocyclyl including from 3-6 atoms, phenyl, or heteroaryl including from 5-6 atoms, each of which can be optionally substituted with one or more substituents; and

• X can be O; and W2025-7029WO / AM102903-PCT

• R¹⁵ can be Ci-C₆ alkyl.

Embodiments can include one or more of the following features:

Each of R₁, R₃, and Rg can be hydrogen, and each of R₂, R₄, and R₉ can be hydroxyl.

Each of R₅ and Rio can be hydrogen.

Each of R₆ and Rn can be CH₃.

R₇ can be C_x-C₆ (e.g., C_x-C₄) alkyl, e.g.., R₇ can be CH₃ or CH₂CH₃ (e.g., CH₃); or straight or branched C₃-C₆ alkyl.

Each of R₁₂ and Ri₃ can be hydrogen.

Ri₄ can be CH₃, and R₁₅ can be CH₃ or CH₂CH₃ (e.g., CH₃); or straight or branched C₃-C₆ alkyl.

In certain embodiments, each of R₁, R₃, and Ks can be hydrogen, and each of R₂, R₄, and R₉ can be hydroxyl; and each of R₅ and Rio can be hydrogen; and each of R₆ and Rn can be CH₃; and R₇ can be CH₃; and X can be O; and each of Ri₂ and Ri₃ can be hydrogen; and each of R_M and Ri₅ can be CH₃.

In one embodiment, the allosamidin-like ligand has the following structure:

wherein, in the case of allosamidin, Ri can be CH₃, R₂ and R₄ can be hydrogen and R₃ can be hydroxyl; wherein, in the case of demethylallosamidin, R₁, R₂ and R₄ can be hydrogen and

R₃ can be hydroxyl; W2025-7029WO / AM102903-PCT

wherein, in the case of methylallosamidin, Ri and R₂ can be CH₃, R₃ can be hydroxyl, and R₄ can be hydrogen; wherein, in the case of glucoallosamidin B, Ri and R₃ can be hydrogen, R₂ can be CH₃ and R₄ can be hydroxyl. Allosamidin-like ligands are described in Rao, F.V., et ah, J. Biol. Chem. 278,

20110-6, 2001 (incorporated by reference herein).

Crystallization and Resolution of AMCase

To determine the structure of human AMCase, a human AMCase-polypeptide can be prepared and crystallized as described below. In general, the human AMCase polypeptide can be prepared as desired. For example, in some embodiments, the human AMCase polypeptide is expressed from a DNA plasmid. The expression can be driven by a promoter, such as an inducible promoter or a constitutive promoter, such as a cytomegalovirus promoter. The human AMCase polypeptide can be expressed as a fusion protein with a suitable tag, such as a polyhistidine (e.g., hexahistidine), glutathione-S-transferase (GST), myc, HA, Strep, or FLAG tag. The tag can facilitate isolation of the human AMCase polypeptide from cells, such as from bacterial cells or from a mammalian cell line. For example, the human AMCase polypeptide can be expressed in and isolated from Chinese Hamster Ovary (CHO) cells. For example, the human AMCase polypeptide can be fused to a hexahistidine tag and isolated by contacting a cell extract with a Nickel resin (e.g., a Nickel-nitrilotriacetic acid (Ni-NTA) resin) to bind the hexahistidine tag, and then releasing the polypeptide by washing the resin with a buffer containing imidazole. Further, a fusion human AMCase polypeptide can be cleaved at a protease site engineered into the fusion protein, such as at or near the site of fusion between the polypeptide and the tag.

The human AMCase polypeptide can be placed in solution for collecting spectral data, NMR data, or for growing a crystal. For example, the human AMCase polypeptide can be crystallized in the presence of a salt (e.g., a sodium salt and/or ammonium salt). For example, the human AMCase polypeptide can be crystallized in the presence of polyethylene glycol (e.g. PEG 2000, PEG 3350, PEG 6000, PEG 8000, PEG 10,000,

PEG 20,000) or polyethylene glycol monomethylether (e.g. PEG MME 750, PEG MME W2025-7029WO / AM102903-PCT

2000). For example, the human AMCase polypeptide can be crystallized in the presence of polyethylene glycol, salts, and buffers (e.g. acetate, citrate, Tris buffers, such as a buffer chosen from one or more of: 25% PEG4000, 0.1M Sodium Acetate, 0.2 M Ammonium Sulfate; 20% PEG 3350, 0.2 M Ammonium Formate; 24.5% PEG 3350, 0.1 5 M bis-tris buffer at pH 6.5; 20% PEG 3350, 0.2 Ammonium Phosphate; 20% PEG 3350, 0.2 Ammonium Fluoride; or 20% PEG 3350, 0.2 di-Ammonium citrate). Crystals can be grown by various methods, such as, for example, sitting or hanging drop vapor diffusion. In general, crystallization can be performed at a temperature of from about 4°C to about 60⁰C (e.g., from about 10⁰C to about 45°C, such as at about 12°C, about 15°C, about o 18°C, about 20⁰C, about 25°C, about 30⁰C, about 32°C, about 35°C, about 37°C).

In general, a crystal of the human AMCase polypeptide can diffract X-rays to a resolution of about 3.7 A or less (e.g., about 3.6 A or less, about 3.5 A or less, about 3.2 A or less, about 3.0 A or less, about 2.7 A or less, about 2.4 A or less, about 2.3 A or less, about 2.2 A or less, about 2.1 A or less, about 2.0 A or less, about 1.9 A or less, about 1.85 A or less, about 1.7 A or less, about 1.6 A or less, about 1.5 A or less, or about 1.4 A or less). In some embodiments, a crystal of the human AMCase polypeptide can diffract X- rays to a resolution of from about 1.7 A to about 3.7 A (e.g., the crystal of the human AMCase polypeptide can diffract X-rays to about 2.7 A, about 3.5 A or about 3.6 A).

In certain embodiments, the crystal of the human AMCase polypeptide belongs to0 space group chosen from P2i or V1{1{1_\. In other embodiments, the crystal of human AMCase polypeptide belongs to space group P2i and has unit cell parameters chosen from one or more of: a=69.9 A, b=92.4 A, c=111.7 A, and α= γ=90° β= 95.9°, with four human AMCase polypeptides or four ligand- AMCase complexes in the asymmetric unit; or a=69.9 A, b=93.3 A, c=87.2 A, and α= γ=90° β= 106.92°, with three ligand-AMCase5 complexes in the asymmetric unit. In other embodiments, the crystal of the human

AMCase-ligand complex belongs to space group V1{1{1_\ and has unit cell parameters chosen from one or more of: a=63.69 A, b=89.29 A, c=126.69 A, and α=β=γ=90°, with two methylallosamidin-bound human AMCase polypeptides in the asymmetric unit; a=45.2 A, b=81.5 A, c=91.9 A, and α=β=γ=90°, with one complex of ligand-bound0 human AMCase in the asymmetric unit; or a=45.3 A, b=81.9 A, c=91.7 A, and α=β=γ=90°, with one ligand-bound human AMCase polypeptide in the asymmetric unit. W2025-7029WO / AM102903-PCT

The space group refers to the overall symmetry of the crystal, and includes point symmetry and space symmetry. In certain embodiments, a crystal of the human AMCase polypeptide belongs to space group P2i and contains four molecules of the human AMCase polypeptide in the asymmetric unit. In other embodiments, a crystal of the 5 human AMCase polypeptide belongs to space group P2i2i2 and contains two molecules of the human AMCase polypeptide in the asymmetric unit. The asymmetric unit is the smallest unit from which the crystal structure can be generated by making use of the symmetry operations of the space group. A crystal is generally made up of the motif defined by the space-group symmetry operations on the asymmetric units, and a o translation of that motif through the crystal lattice.

Structural data describing a crystal can be obtained, for example, by X-ray diffraction and phases. X-ray diffraction data can be collected by a variety of sources, X- ray wavelengths and detectors. In some embodiments, rotating anodes and synchrotron sources (e.g., Advanced Light Source (ALS), Berkeley, California; or Advanced Photon5 Source (APS), Argonne, Illinois) can be used as the source(s) of X-rays. In certain embodiments, X-rays for generating diffraction data can have a wavelength of from about 0.5 A to about 1.6 A (e.g., about 0.7 A, about 0.9 A, about 1.0 A, about 1.1 A, about 1.3 A, about 1.4 A, about 1.5 A, or about 1.6 A). In some embodiments, area detectors and/or charge-couple devices (CCDs) can be used as the detector(s). 0 X-ray diffraction data of a crystal of the human AMCase polypeptide can be used together with phases to obtain the structural coordinates of the atoms in the crystal. The structural coordinates are Cartesian coordinates that describe the location of atoms in three-dimensional space in relation to other atoms in the polypeptide or complex. For example, the structural coordinates listed in Table 1 are the structural coordinates of a5 crystalline human AMCase polypeptide. For example, the structural coordinates listed in Table 2 are the structural coordinates of a crystalline methylallosamidin-bound human AMCase polypeptide. The structural coordinates of Table 1 describe the location of atoms of the human AMCase polypeptide in relation to each other. The structural coordinates can be modified by mathematical manipulation, such as by inversion or0 integer additions or subtractions. As such, structural coordinates are relative coordinates. For example, structural coordinates describing the location of atoms in the human W2025-7029WO / AM102903-PCT

AMCase polypeptide are not specifically limited by the actual x, y, and z coordinates of Table 1. For example, structural coordinates describing the location of atoms in the methylallosamidin-bound human AMCase polypeptide are not specifically limited by the actual x, y, and z coordinates of Table 2. The structural coordinates of the human AMCase polypeptide can be used to derive a representation (e.g., a two dimensional representation or three dimensional representation) of the polypeptide or a fragment of the polypeptide. Such representations can be useful for a number of applications, including, for example, the visualization, identification and characterization of an active site of the polypeptide. In certain embodiments, a three-dimensional representation can include the structural coordinates of the human AMCase polypeptide according to Table 1, + a root mean square (rms) deviation from the alpha carbon atoms of amino acids of not more than about 1.5 A (e.g., not more than about 1.0 A, not more than about 0.5 A). In certain embodiments, a three- dimensional representation can include the structural coordinates of the methylallosamidin-bound human AMCase polypeptide according to Table 2, + a root mean square (rms) deviation from the alpha carbon atoms of amino acids of not more than about 1.5 A (e.g., not more than about 1.0 A, not more than about 0.5 A)

Root mean square deviation (rms deviation, or rmsd) is the square root of the arithmetic mean of the squares of the deviations from the mean, and is a way of expressing deviation or variation from structural coordinates. Conservative substitutions of amino acid residues can result in a molecular model having structural coordinates within the stated root mean square deviation. In particular, two molecular models of polypeptides that differ from one another by conservative substitutions can have coordinates of backbone atoms within a stated rms deviation, such as less than 1.5 A, less than 1.0 A, or less than 0.5 A. Backbone atoms of a polypeptide include the alpha carbon (C_α or CA) atoms, carbonyl carbon (C) atoms, carbonyl oxygen (O) atoms, and amide nitrogen (N) atoms. In one embodiment, the rmsd between uncomplexed AMCase and methylallosamidin-bound AMCase (C_α) is 1.063. In another embodiment, the rmsd between uncomplexed AMCase and uncomplexed human chitriosidase (C_α) is 0.0664. The numbering of the amino acid residues of AMCase may be different than set forth here, and may contain certain conservative amino acid substitutions, additions or W2025-7029WO / AM102903-PCT

deletions that yield the same three-dimensional structures as those defined by Table 1 or 2, + an rmsd for backbone atoms of less than 1.5 A. Corresponding amino acids and conservative substitutions in other isoforms or analogs are easily identified by visual inspection of the relevant amino acid sequences or by using commercially available homology software programs (e.g., MODELLAR, MSI, San Diego, CA). An isoform is any of several multiple forms of a protein that differ in their primary structure. An analog is a polypeptide having conservative amino acid substitutions.

Various software programs allow for the graphical representation of a set of structural coordinates to obtain a representation of the human AMCase polypeptide or a fragment of the polypeptide. In general, such a representation should accurately reflect (relatively and/or absolutely) structural coordinates, or information derived from structural coordinates, such as distances or angles between features. In some embodiments, the representation is a two-dimensional figure, such as a stereoscopic two- dimensional figure. In certain embodiments, the representation is an interactive two- dimensional display, such as an interactive stereoscopic two-dimensional display. An interactive two-dimensional display can be, for example, a computer display that can be rotated to show different faces of a polypeptide or a fragment of a polypeptide. In some embodiments, the representation is a three-dimensional representation. As an example, a three-dimensional model can be a physical model of a molecular structure (e.g., a ball- and-stick model). As another example, a three dimensional representation can be a graphical representation of a molecular structure (e.g., a drawing or a figure presented on a computer display). A two-dimensional graphical representation (e.g., a drawing) can correspond to a three-dimensional representation when the two-dimensional representation reflects three-dimensional information, for example, through the use of perspective, shading, or the obstruction of features more distant from the viewer by features closer to the viewer. In some embodiments, a representation can be modeled at more than one level. As an example, when the three-dimensional representation includes a polypeptide, such as a human AMCase polypeptide, the polypeptide can be represented at one or more different levels of structure, such as primary (amino acid sequence), secondary (e.g., I-helices and Φ-sheets), tertiary (overall fold), and quaternary (oligomerization state) structure. As an example, when the three-dimensional W2025-7029WO / AM102903-PCT

representation includes a polypeptide and an inhibitor, such as a methylallosamidin- bound human AMCase polypeptide, the polypeptide can be represented at one or more different levels of structure, such as primary (amino acid sequence), secondary (e.g., I- helices and Φ-sheets), tertiary (overall fold), and quaternary (oligomerization state) structure, and the inhibitor can be represented as ball-and-stick, space-filling, or pharmacophores. A representation can include different levels of detail. For example, the representation can include the relative locations of secondary structural features of a protein without specifying the positions of atoms. A more detailed representation could, for example, include the positions of atoms. In some embodiments, a representation can include information in addition to the structural coordinates of the atoms in the human AMCase polypeptide or in an inhibitor- bound human AMCase polypeptide, e.g. methylallosamidin-bound human AMCase polypeptide. For example, a representation can provide information regarding the shape of a solvent accessible surface, the van der Waals radii of the atoms of the model, and the van der Waals radius of a solvent (e.g., water). Other features that can be derived from a representation include, for example, electrostatic potential, the location of voids or pockets within a macromolecular structure, and the location of hydrogen bonds and salt bridges.

As noted above, X-ray crystallography can be used to obtain structural coordinates of the human AMCase polypeptide and inhibitor-bound human AMCase polypeptide, e.g. methylallosamidin-bound human AMCase polypeptide. However, such structural coordinates can be obtained using other techniques including NMR techniques. Some structural information can also be obtained from spectral techniques (e.g., optical rotary dispersion (ORD), circular dichroism (CD)), homology modeling, and computational methods (e.g., computational methods that can include data from molecular mechanics, computational methods that include data from dynamics assays). In some embodiments, the X-ray diffraction data together with its phases can be used to construct an electron density map of the human AMCase polypeptide or a fragment of the polypeptide, and the electron density map can be used to derive a representation (e.g., a two dimensional representation, a three dimensional representation) of the human AMCase polypeptide. Creation of an electron density map W2025-7029WO / AM102903-PCT

typically involves using information regarding the phase of the diffracted X-rays. Phase information can be extracted, for example, either from the diffraction data or from supplementing diffraction experiments to complete the construction of the electron density map. Methods for calculating phase from X-ray diffraction data include, for example, multiwavelength anomalous dispersion (MAD), multiple isomorphous replacement (MIR), multiple isomorphous replacement with anomalous scattering (MIRAS), single isomorphous replacement with anomalous scattering (SIRAS), or any combination thereof.

Some of these methods generate phase information by making isomorphous structural modifications to the native protein, such as by including a heavy atom or changing the scattering strength of a heavy atom already present, and then measuring the diffraction amplitudes for the native protein and each of the modified cases. If the position of the additional heavy atom or the change in its scattering strength is known, then the phase of each diffracted X-ray can be determined by solving a set of simultaneous phase equations. The location of heavy atom sites can be identified using a computer program, such as SHELXD (Bruker-AXS, Madison, WI) or SHELXS (Sheldrick, Institut Anorg. Chemie, Gδttingen, Germany), and XPREP (Bruker-AXS, Madison, WI); and diffraction data can be processed using computer programs such as MOSFLM, SCALA, SOLOMON, and SHARP ("The CCP4 Suite: Programs for Protein Crystallography," Acta Crystallogr. Sect. D₁ 54:905-921, 1997; deLa Fortelle and Brigogne, Meth. Enzym. 276:472-494, 1997).

The phases of the diffracted X-rays of crystalline human AMCase polypeptide, for example, can be obtained by molecular replacement techniques, such as AMORE, with a starting model based on a similar protein of the glycohydrolase family 18, e.g. human chitotriosidase, and refined against the observed structure factors. The resulting model, can then be used to solve a different crystal structure of human AMCase poylpeptide and/or methylallosamidin-bound human AMCase polypeptide and/or inhibitor-bound human AMCase polypeptide by molecular replacement. For example, a model derived from a crystalline human AMCase polypeptide having space group P2i can be used as a search model to solve a crystalline methylallosamidin-bound human AMCase polypeptide having space group P2₁2₁2₁. For example, a model derived from W2025-7029WO / AM102903-PCT

either crystalline human AMCase polypeptide having space group P2i or a crystalline methylallosamidin-bound human AMCase polypeptide having space group P2₁2₁2₁ can be used as a search model to solve by molecular replacement techniques the crystal structure of an inhibitor-bound human AMCase polypeptide in any space group available to molecules that have at least one chiral atom, e.g. Pl, P2, P2i, C2, P222, P222_1; P2₁2₁2, P2i2i2i, C222, C222i, F222, 1222, 12i2i2i, P4, P4i, P4₃, P4₂, 14, U₁, P422, P4i22, P4₃22, P4₂22, P42i2, P4i2i2, P4₃2i2, P4₂2i2, 1422, 14i22, P3, P3_ls P3₂, R3, P321, P312, P3i21, P3₂21, P3il2, P3₂12, R32, P6, P6i, P6₅, P6₂, P6₄, P6₃, P622, P6i22, P6₅22, P6₂22, P6₄22, P6₃22, P23, P2i3, F23, 123, 12i3, P432, P4i32, P4₃32, P4₂32, F432, F4i32, 1432, 14_t32. In other embodiments, the electron density map can be used to derive a representation of a polypeptide or a fragment of a polypeptide by aligning a three- dimensional model of a polypeptide with the electron density map. For example, the electron density map corresponding to the native crystalline human AMCase polypeptide can be aligned with the electron density map corresponding to the platinum derivative of the crystalline human AMCase polypeptide complex derived by an isomorphous replacement method.

The alignment process results in a comparative model. The comparative model is then refined over one or more cycles (e.g., two cycles, three cycles, four cycles, five cycles, six cycles, seven cycles, eight cycles, nine cycles, ten cycles) to generate a better fit with the electron density map. Software programs such as CNS (Brunger et al, Acta Crystallogr. D54:905-921, 1998) and REFMAC (Collaborative Computational Project, Number 4. The CCP4 suite: Programs for Protein Crystallography, Acta Crystallogr. D50:760-776, 1994) can be used to refine the model. The quality of fit in the comparative model can be measured by, for example, an Rf_actor or Rf_ree value. A smaller value of Rfactor or Rf_ree generally indicates a better fit. Misalignments in the comparative model can be adjusted to provide a modified comparative model and a lower Rfactor or R_free value. The adjustments can be based on information relating to variations of the human AMCase polypeptide (e.g., sequence variation information, alternative structure information, heavy atom derivative information) as appropriate. As an example, in embodiments in which a model of a heavy atom derivative of a crystalline human

AMCase polypeptide is used, an adjustment can include fitting an approximate model of W2025-7029WO / AM102903-PCT

the native human AMCase polypeptide over the model of the heavy atom derivative. As another example, in certain embodiments, an adjustment can include replacing an amino acid in the previously known human AMCase polypeptide with an amino acid having a similar structure (a conservative amino acid change). When adjustments to the modified comparative model satisfy a best fit to the electron density map, the resulting model is that which is determined to describe the polypeptide or complex from which the X-ray data was derived. Methods of such processes are disclosed, for example, in Carter and Sweet, eds., "Macromolecular Crystallography" in Methods in Enzvmology, Vol. 277, Part B, New York: Academic Press, 1997, and articles therein, e.g., Jones and Kjeldgaard, "Electron-Density Map Interpretation," p. 173, and Kleywegt and Jones, "Model Building and Refinement Practice," p. 208.

A machine, such as a computer, can be programmed in memory with the structural coordinates of the human AMCase polypeptide together with a program capable of generating a graphical representation of the structural coordinates on a display connected to the machine. A software system can also be designed and/or utilized to accept and store the structural coordinates. The software system can be capable of generating a graphical representation of the structural coordinates. The software system can also be capable of accessing external databases to identify one or more candidate agents likely to interact with the human AMCase polypeptide. A machine having a memory containing structure data or a software system containing such data can aid in the rational design or selection of a human AMCase polypeptide agonist of a human AMCase polypeptide antagonist. For example, such a machine or software system can aid in the evaluation of the ability of an agent to associate with the human AMCase polypeptide, or can aid in the modeling of compounds or proteins related by structural or sequence homology to the human AMCase polypeptide. As used herein, an agonist refers to a compound that enhances at least one activity of the human AMCase polypeptide, and an antagonist refers to a compound that inhibits or counteracts at least one activity of the human AMCase polypeptide. For example, a compound may function as an antagonist of the human AMCase polypeptide by, for example, increasing the rate of myelin production by a neural cell, or by inhibiting interaction of the human AMCase polypeptide with the Nogo receptor complex. W2025-7029WO / AM102903-PCT

The machine can produce a representation (e.g., a two dimensional representation, a three dimensional representation) of the human AMCase polypeptide or a fragment of the polypeptide. A software system, for example, can cause the machine to produce such information. The machine can include a machine-readable data storage medium including a data storage material encoded with machine-readable data. The machine- readable data can include structural coordinates of atoms of the human AMCase polypeptide. Machine-readable storage media (e.g., data storage material) include, for example, conventional computer hard drives, floppy disks, DAT tape, CD-ROM, DVD, and other magnetic, magneto-optical, optical, and other media which may be adapted for use with a machine (e.g., a computer). The machine can also have a working memory for storing instructions for processing the machine-readable data, as well as a central processing unit (CPU) coupled to the working memory and to the machine-readable data storage medium for the purpose of processing the machine-readable data into the desired three-dimensional representation. A display can be connected to the CPU so that the three-dimensional representation can be visualized by the user. Accordingly, when used with a machine programmed with instructions for using the data (e.g., a computer loaded with one or more programs of the sort described herein) the machine is capable of displaying a graphical representation (e.g., a two dimensional graphical representation, a three-dimensional graphical representation) of any of the polypeptides, polypeptide fragments, complexes, or complex fragments described herein.

A display (e.g., a computer display) can show a representation of the human AMCase polypeptide or a fragment of the human AMCase polypeptide (e.g., the AMCase ligand binding domain). In certain embodiments, the X-ray coordinates of the human AMCase ligand binding domain as shown in Tables 1 and 2 can be transformed into a visual depiction, e.g., a three-dimensional representation or model. Such representation or model can be visualized, e.g., electronically in a computer. The user can inspect the representation and, using information gained from the representation, generate a model of the human AMCase polypeptide or polypeptide fragment bound to a inhibitor. The model can be generated, for example, by altering a previously existing representation of the human AMCase polypeptide. Optionally, the user can superimpose a three-dimensional model of an agent on the representation of the human AMCase W2025-7029WO / AM102903-PCT

polypeptide. The agent can be an agonist (e.g., a candidate agonist) of the human AMCase polypeptide. In some embodiments, the agent can be a known compound or a fragment of a known compound. In certain embodiments, the agent can be a previously unknown compound, or a fragment of a previously unknown compound. The agent, alone or complexed with the AMCase polypeptide, can be displayed, e.g., in a computer. It can be desirable for the agent to have a shape that complements the shape of the active site. There can be a preferred distance, or range of distances, between atoms of the agent and atoms of the human AMCase polypeptide. Distances longer than a preferred distance may be associated with a weak interaction between the agent and active site (e.g., the active site of the human AMCase polypeptide). Distances shorter than a preferred distance may be associated with repulsive forces that can weaken the interaction between the agent and the polypeptide. A steric clash can occur when distances between atoms are too short. A steric clash occurs when the locations of two atoms are unreasonably close together, for example, when two atoms are separated by a distance less than the sum of their van der Waals radii. If a steric clash exists, the user can adjust the position of the agent relative to the human AMCase polypeptide (e.g., a rigid body translation or rotation of the agent) until the steric clash is relieved. The user can adjust the conformation of the agent or of the human AMCase polypeptide in the vicinity of the agent in order to relieve a steric clash. Steric clashes can also be removed by altering the structure of the agent, for example, by changing a "bulky group," such as an aromatic ring, to a smaller group, such as to a methyl or hydroxyl group, or by changing a rigid group to a flexible group that can accommodate a conformation that does not produce a steric clash. Electrostatic forces can also influence an interaction between an agent and an inhibitor-binding domain. For example, electrostatic properties can be associated with repulsive forces that can weaken the interaction between the agent and the human AMCase polypeptide. Electrostatic repulsion can be relieved by altering the charge of the agent, e.g., by replacing a positively charged group with a neutral group.

Forces that influence binding strength between a candidate agent and the human AMCase polypeptide, respectively, can be evaluated in the polypeptide/agent model. These can include, for example, hydrogen bonding, electrostatic forces, hydrophobic interactions, van der Waals interactions, dipole-dipole interactions, π-stacking forces, and W2025-7029WO / AM102903-PCT

cation-π interactions. The user can evaluate these forces visually, for example by noting a hydrogen bond donor/acceptor pair arranged with a distance and angle suitable for a hydrogen bond. Based on the evaluation, the user can alter the model to find a more favorable interaction between the human AMCase polypeptide and the agent. Altering the model can include changing the three-dimensional structure of the polypeptide without altering its chemical structure, for example by altering the conformation of amino acid side chains or backbone dihedral angles. Altering the model can include altering the position or conformation of the agent, as described above. Altering the model can also include altering the chemical structure of the agent, for example by substituting, adding, or removing groups. For example, if a hydrogen bond donor on the human AMCase polypeptide is located near a hydrogen bond donor on the agent, the user can replace the hydrogen bond donor on the agent with a hydrogen bond acceptor.

The relative locations of an agent and the human AMCase polypeptide, or their conformations, can be adjusted to find an optimized binding geometry for a particular agent to the human AMCase polypeptide. An optimized binding geometry is characterized by, for example, favorable hydrogen bond distances and angles, maximal electrostatic attractions, minimal electrostatic repulsions, the sequestration of hydrophobic moieties away from an aqueous environment, and the absence of steric clashes. The optimized geometry can have the lowest calculated energy of a family of possible geometries for the human AMCase polypeptide/agent complex. An optimized geometry can be determined, for example, through molecular mechanics or molecular dynamics calculations.

A series of representations of the human AMCase polypeptide having different bound agents can be generated. A score can be calculated for each representation. The score can describe, for example, an expected strength of interaction between the human AMCase polypeptide and the agent. The score can reflect one of the factors described above that influence binding strength. The score can be an aggregate score that reflects more than one of the factors. The different agents can be ranked according to their scores. Steps in the design of the agent can be carried out in an automated fashion by a machine. For example, a representation of the human AMCase polypeptide can be W2025-7029WO / AM102903-PCT

programmed in the machine, along with representations of candidate agents. The machine can find an optimized binding geometry for each of the candidate agents to an active site, and calculate a score to determine which of the agents in the series is likely to interact most strongly with the human AMCase polypeptide. A software system can be designed and/or implemented to facilitate these steps.

Software systems (e.g., computer programs) used to generate representations or perform the fitting analyses include, for example: MCSS, Ludi, QUANTA® (macromolecular X- ray crystallography software), Insight II® (biological compound modeling and simulation software), Cerius ® (modeling and simulation software), CHARMm® (software for simulation of biological macromolecules), and Modeler from Accelrys, Inc. (San Diego, CA); SYBYL® (molecular modeling software), Unity, FIeXX, and LEAPFROG from TRIPOS, Inc. (St. Louis, MO); AUTODOCK (Scripps Research Institute, La Jolla, CA); GRID (Oxford University, Oxford, UK); DOCK (University of California, San Francisco, CA); and FIo+ and Flo99 (Thistlesoft, Morris Township, NJ). Other useful programs include ROCS, ZAP, FRED, Vida, and Szybki from Openeye Scientific Software (Santa Fe, NM); Maestro, Macromodel, and Glide from Schrodinger, LLC (Portland, OR); MOE (Chemical Computing Group, Montreal, Quebec), Allegrow (Boston De Novo, Boston, MA), CNS (Brunger, et al, Acta Cry stall. Sect. D 54:905-921, 1997) and GOLD (Jones et al., J. MoI. Biol. 245:43-53, 1995). The structural coordinates can also be used to visualize the three-dimensional structure of the human AMCase polypeptide using MOLSCRIPT, RASTER3D, or PYMOL (Kraulis, /. Appl. Crystallogr. 24: 946-950, 1991; Bacon and Anderson, /. MoI. Graph. 6: 219-220, 1998; DeLano, The PYMOL Molecular Graphics System (2002) DeLano Scientific, San Carlos, CA).

The inhibitor can, for example, be selected by screening an appropriate database, can be designed de novo by analyzing the steric configurations and charge potentials of a methylallosamidin-bound human AMCase polypeptide and/or human AMCase polypeptide, in conjunction with the appropriate software systems, and/or can be designed using characteristics of known inhibitors, such methylallosamidin, as revealed by the methylallosamidin-bound human AMCase polypeptide crystal structure. The method can be used to design or select inhibitors of the human AMCase polypeptide. A W2025-7029WO / AM102903-PCT

software system can be designed and/or implemented to facilitate database searching, and/or agent selection and design.

Once an agent has been designed or identified, it can be obtained or synthesized and further evaluated for its effect on the activity of the human AMCase polypeptide. For example, the agent can be evaluated by contacting it with the human AMCase polypeptide and measuring the effect of the agent on polypeptide activity. A method for evaluating the agent can include an activity assay performed in vitro or in vivo.

In one embodiment, an activity of an AMCase can be assayed as follows. The sample (e. g., tissue, cell culture, or amount of AMCase) is typically contacted with a test agent for a time period sufficient to inhibit the activity or expression of the chitinase. This time period may vary depending on the nature of the test agent, the AMCase, the activity or expression detection method selected, and the sample tissue selected. The skilled artisan without undue experimentation may readily determine such times. An exemplary test agent is one that binds to or otherwise decreases the catalytic activity of an AMCase, although test agents that inhibit AMCase activity or expression by, for example, binding to the substrate for AMCase, or binding to a component of the signal pathway, such as IL- 13R, IL-4R or IL- 13 are also envisioned. An exemplary substrate for chitinase is chitin, although derivatives thereof that may participate in a reaction catalyzed by chitinase are also encompassed by the invention. A wide variety of assays may be utilized to determine whether the candidate agent inhibits the activity of the AMCase. For example, the amount of reactants remaining and/or products formed in reactions catalyzed by AMCase may be quantified. A non- limiting example of such a reaction is the conversion of chitin or a chitin-like compound to N-acetyl-D-glucosamine. Other reactions include, without limitation, the release of 4- methylumbelliferyl from 4-methylumbelliferyl- tri-N-acetyl chitotrioxide, 4- methylumbelliferyl -D-N, N'-diacetylchitobiose or 4-methylumbelliferyl -D-N, N', N"- triacetylchitotriose; or the release of p- nitrophenylfrom p-nitrophenyl P-D-O-D-N, N'- diacetylchitobiose or p-nitrophenyl -D-N,N', N"-triacetylchitotriose. To this end, the amount of chitin remaining after contacting AMCase with the test agent as a function of time may be determined. Similarly, the amount of N-acetyl-D-glucosamine or 4- methylumbelliferyl or p-nitrophenyl produced after contacting chitinase with the test W2025-7029WO / AM102903-PCT

agent in the presence of, for example, chitin as a function of time may be determined. Various assays may be used to determine the quantity of these products and/or reactants. For example, colorimetric assays may be utilized to determine the quantity of N-acetyl- D-glucosamine as described in, for example, Reissig, J. L.,J. Biol.Chers. 217:959-966, 1955. Alternatively, the amount of glucosamine may be determined by chromatographic methods known to the skilled artisan, including high performance liquid chromatography, as described in, for example, Ekblad, A. (1996) Plant and Soil 178:29-35. Fluorometric assays may be utilized to determine the quantity of 4- methylumbelliferylorp-nitrophenyl as described in, for example, U. S. Patent No. 5,561, 051 (Silverman); Houston, D. R., et ai, PNAS 99:9127-9232, 2002; Hollak, C. E. M., et al, J. Clin. Invest. 93: 1288-1292, 1994; and Hu et al, J. Biol. Chem. 271: 19415-194520. Methods of quantitating chitin are known to the art, including use of various immunoassays, such as enzyme-linked immunosorbents assays. Such assays, and others, are discussed in Muzzarelli R. A. A. and M. G. Peter, eds., Chitin Handbook, European Chitin Society, Atec, Grottammare (1997). A wide variety of candidate agents may be tested in the screening methods of the present invention. For example, small molecule compounds, known in the art, synthetic small molecule chemicals, nucleic acids such as antisense oligonucleotides, RNA inhibitors such as siRNA, ribozymes, and aptamers, peptides and proteins such as hormones, antibodies, and portions thereof, may act as candidate agents. The candidate agents of the present invention can be obtained using any of the numerous approaches in combinatorial library methods known in the art, including: biological libraries; peptoid libraries (libraries of molecules having the functionalities of peptides, but with a novel, non-pep tide backbone which are resistant to enzymatic degradation but which nevertheless remain bioactive; see, e.g., Zuckermann, R.N. et al. (1994) /. Med. Chem. 37:2678-85); spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring decon volution; the 'one-bead one- compound' library method; and synthetic library methods using affinity chromatography selection. The biological library and peptoid library approaches are limited to peptide libraries, while the other four approaches are applicable to peptide, non-peptide oligomer or small molecule libraries of compounds (Lam (1997) Anticancer Drug Des. 12: 145). W2025-7029WO / AM102903-PCT

Examples of methods for the synthesis of molecular libraries can be found in the art, for example in: DeWitt et al. (1993) Proc. Natl. Acad. ScL U.S.A. 90:6909; Erb et al. (1994) Proc. Natl. Acad. ScL USA 91 :11422; Zuckermann et al. (1994). /. Med. Chem. 37:2678; Cho et al. (1993) Science 261:1303; Carrell et al. (1994) Angew. Chem. Int. Ed. Engl. 33:2059; Carell et al. (1994) Angew. Chem. Int. Ed. Engl. 33:2061 ; and Gallop et al. (1994) /. Med. Chem. 37:1233.

Libraries of compounds may be presented in solution (e.g., Houghten (1992) Biotechniques 13:412-421), or on beads (Lam (1991) Nature 354:82-84), chips (Fodor (1993) Nature 364:555-556), bacteria (Ladner, U.S. Patent No. 5,223,409), spores (Ladner U.S. Patent No. 5,223,409), plasmids (Cull et al. (1992) Proc Natl Acad Sci USA 89: 1865-1869) or on phage (Scott and Smith (1990) Science 249:386-390; Devlin (1990) Science 249:404-406; Cwirla et al. (1990) Proc. Natl. Acad. ScL 87:6378-6382; Felici (1991) /. MoI. Biol. 222:301-310; Ladner supra.).

Various molecular analysis and rational drug design techniques are further disclosed in, for example, U.S. Patent Nos. 5,834,228, 5,939,528 and 5,856,116, as well as in PCT Application No. PCT/US98/16879, published as WO 99/09148.

A number of embodiments of the invention have been described. Nevertheless, it will be understood that various modifications may be made without departing from the spirit and scope of the invention. EXAMPLES

Example 1 : Crystallization and Structural Resolution of Human AMCase

Human acidic mammalian chitinase (AMCase) was overpressed, purified and crystallized in at least six different crystal forms suitable for high resolution structure determination using the techniques of protein macromolecular X-ray crystallography. The X-ray structures of a human AMCase polypeptide and an inhibitor-bound form of human AMCase human AMCase polypeptide were determined to a resolution of 2.0 A and 1.7 A, respectively (see Example 2). Example 3 summarizes crystallization conditions and crystal space unit and parameters for four additional complexes of human AMCase with four different compounds. Experimental conditions used in expressing and crystallizing the human AMCase are provided in more detail herein. W2025-7029WO / AM102903-PCT

Cloning and Purification of AMCase

A nucleotide sequence encoding truncated human AMCase mutated at position 354 to replace a serine by a phenylalanine (S354F) was cloned into pTMED vector. A histidine tag is attached at the C-terminal end to facilitate protein purification. The vector was expressed in CHO cells. Culture conditions for the CHO cells are provided in more detail below. The nucleotide and amino acid sequence of the truncated human AMCase protein used for the crystallization (SEQ ID NO:1 and SEQ ID NO: 2, respectively) has the following nucleotide and amino acid sequences:

A-hAMC-S354F-AAP-ORF atssccaascttattctcctcacasstcttstccttatactsaatttscasctcssctctscctaccasc tgacatgctacttcaccaactgggcccagtaccggccaggcctggggcgcttcatgcctgacgacatcaa cccctgcctctgtacccacctgatctacgcctttgctgggatgcagaacaacgagatcaccaccatcgaa tggaatgatgtgactctctaccaagctttcaatggcctgaaaaataagaacagccagctgaaaactctcc tssccattssassctssaacttcsssactscccctttcactsccatsstttctactcctsasaaccscca gactttcatcacctcagtcatcaaattcctgcgccagtatgagtttgacgggctggactttgactgggag taccctssctctcstsssasccctcctcassacaascatctcttcactstcctsstscassaaatscsts aascttttsascassassccaascasatcaacaascccassctsatsstcactsctscastasctsctss catctccaatatccagtctggctatgagatcccccaactgtcacagtacctggactacatccatgtcatg acctacgacctccatggctcctgggagggctacactggagagaacagccccctctacaaatacccgactg acaccsscascaacscctacctcaatstssattatstcatsaactactssaassacaatssascaccasc tgagaagctcatcgttggattccctacctatggacacaacttcatcctgagcaacccctccaacactgga attsstscccccacctctsstsctsstcctsctsssccctatsccaassastctsssatctssscttact acgagatctgtaccttcctgaaaaatggagccactcagggatgggatgcccctcaggaagtgccttatgc ctatcagggcaatgtatgggttggctatgacaacgtcaagagcttcgatattaaggctcaatggcttaag cacaacaaattcggaggcgccatggtctgggccattgatctggatgacttcactggcactttctgcaacc agggcaagtttcccctaatctccaccctgaagaaggccctcggcttgcagagtgcaagttgcacggctcc agctcagcccattgagccaataactgctgctcccggctcccatcaccatcaccatcactag (SEQ ID NO:1)

YQLTCYFTN WAQYRPGLGR FMPDDINPCL CTHLIYAFAG MQNNEITTIE WNDVTLYQAF NGLKNKNSQL KTLLAIGGWN

FGTAPFTAMV STPENRQTFI TSVIKFLRQY EFDGLDFDWE YPGSRGSPPQ

DKHLFTVLVQ EMREAFEQEA KQINKPRLMV TAAVAAGISN IQSGYEIPQL W2025-7029WO /AM102903-PCT

SQYLDYIHVM TYDLHGSWEG YTGENSPLYK YPTDTGSNAY LNVDYVMNYW

KDNGAPAEKL IVGFPTYGHN FILSNPSNTG IGAPTSGAGP AGPYAKESGI

WAYYEICTFL KNGATQGWDA PQEVPYAYQG NVWVGYDNVK SFDIKAQWLK

HNKFGGAMVW AIDLDDFTGT FCNQGKFPLI STLKKALGLQ SASCTAPAQP iEPiTAAPGS HHHHHH* (SEQIDNO:2)

The S354 mutated human AMCase was generated because the cloned human cDNA had a serine residue at position 354, which resulted in an N-linked glycosylation site. In examining other cDNA encoding human AMCase, it was discovered that position 354 is a polymorphism, and that a phenylalanine at that position is at least as prevalent as the S. Therefore, when the truncated form was made for crystallization, the serine was changed to a phenylalanine at position 354 in order to avoid an N-linked glycosylated protein.

Cell Growth and Induction of Expression of AMCase

A Chinese Hamster Ovary cell line (CHO PA-DUKX) was used to express the truncated human AMCase polypeptide, with an N-terminal HBML signal sequence and a C-terminal 6-His-tag (SEQ ID NO: 7). The cell line was maintained in alpha media with 10% heat inactivated and dialyzed FBS, 2mM Glutamine, 100 U/ml Penicillin, 100ug/ml Streptomycin, 2.5ug/ml Fungizone and 20OnM Methotrexate. Cells were then scaled up and seeded in roller bottles (1700 sq. cm) in growth media. When the cells reached confluence, the media was replaced with R5CD1 serum- free media. Conditioned media was collected every 48-72 hrs.

Purification of AMCase

The truncated human AMCase was purified from serum- free CHO conditioned media using Ni-NTA Superflow resin (Qiagen Inc., Valencia, CA). One liter of media was applied, batch-wise, to 6 mL Ni-NTA resin at 4 ⁰C within 1 hr. Unbound protein was washed away using wash buffer (50 mM Tris, pH 8.0, 0.3 M NaCl, and 10 mM Imidazole). Human AMCase was then eluted using wash buffer plus 200 mM Imidazole. Human AMCase was further purified by Superdex-200 (Amersham Biosciences Inc.,

Piscataway, NJ) gel-filtration chromatography in 25 mM Tris, pH 8.0, 0.4 M NaCl. The W2025-7029WO / AM102903-PCT

protein was concentrated using Centricon Centrifugal Filter Units (Millipore, Billerica,

MA).

Methylallosamidin production and isolation A strain of streptomyces was grown in 10-L fermentation vessels on a medium containing nutrasoy (12.5 g/L), dextrose (12.5 g/L), N-Z amine (12.5 g/L), NH₄Cl (1.5 g/L), and CaCl₂ (1.0 g/L) with the pH adjusted to 6.8, to produce mainly methylallosamidin and other allosamidins (Sakuda et al. (1987) /. Antibio. (Tokyo) 40(3):296-300) at titers of - 5mg/L after 5 days. The titers of the allosamidins and the progress of methylallosamidin isolation and purification were followed by LCMS using positive ion ms-peaks in the 609 to 637 range.

Due to the occurrence of methylallosamidin in both the medium and pellet, the fermentation batch was stored at 4⁰C for 3 to 5 days following fermentation. The mash was then centrifuged to remove the pellet cell paste. The pH of the supernatant was subsequently adjusted to pH 9.2 using NH₄OH and passed over an open HP-20 column (4 x 36 cm) and the column was washed with 2 L of 0.01 m NH₄OH. A methylallosamidin- rich fraction was then eluted from the column using 1 L of 0.01 m CH₃COOH solution containing 20% methanol. This fraction was concentrated under vacuum to remove methanol. The pH of the concentrated fraction (-250 mL) was adjusted to pH 8 with NaOH and this was added to a prepared bulk Cis-silica-gel column (3 x 13 cm) and washed with 100 mL water. Absorbed methylallosamidin was then eluted with 0.1% CH₃COOH. Cuts of 40 mL fractions were taken with the bulk of the methylallosamidin eluting in fractions 5 and 6. These were pooled and concentrated to ca. 5 mL and added to a prepared LH-20 column (3 x 30 cm) packed in a methanol/water 50:50. The column was developed with the same solvent system yielding methylallosamidin in fractions 7 and 8. Methanol was evaporated and the aqueous solution was freeze-dried to yield 27.1 mg of a white, fluffy powder, containing mostly methylallosamidin (87% by LCMS).

Crystallization Conditions and X-Ray Analysis Diffraction-quality crystals of human AMCase, suitable for high resolution X-ray analysis, were grown by hanging drop vapor diffusion. Equal volumes (1.0 uL each) of W2025-7029WO / AM102903-PCT

AMCase, purified as above and concentrated to 21 mg/ml in 25 mM Tris, pH 7.5, 50 mM NaCl, and well solution (15% PEG 3350, 120 mM Ammonium Sulfate, 60 mM Na Acetate pH 4.6) were mixed in the hanging drop. Rectangular crystals at 18°C grew in about one week, and generally measured -80 microns, or micrometers across. Crystals of human AMCase polypeptide, grown in the absence of exogenously added inhibitor, were drawn through a solution of 25% glycerol and 75% well solution, and cooled rapidly in liquid nitrogen. Diffraction data were recorded at the Advanced Light Source Beamline 5.0.1 on a q-210 ccd camera (Berkeley, CA). Intensities were integrated and scaled using the programs Denzo and Scalepack (Otwinowski and Minor, 1997). The crystals belong to the space group P2i with unit cell parameters a = 69.94 A, b = 92.36 A, c = 111.67 A, a=^γ=90°, β=95.92°. There are four molecules of human AMCase polypeptide in the asymmetric unit, with a calculated solvent content of approximately 39.5%. The amino acid range visible and modeled for the apo AMCase corresponded to amino acids 22-400 of the full length human AMCase sequence for all 4 molecules of the apo structure, with the exception of amino acids 231 to 236 of chain B. The crystal structure of human AMCase polypeptide (approximately amino acid residues 22-400 of the full length AMCase sequence) was determined by molecular replacement, using the protein model of the human chitotriosidase (Fusetti et al. (2002) Journal of Biological Chemistry 277(28):25537-25544) as the search model, PDB ID code IGUV (all atoms were used not just C alpha backbone). After several iterative cycles of refinement using CNX (Brunger et al. (1998) Acta Cryst. D54:905-921) and Refmac5 (CCP4), and model improvement in Coot (Emsley, P. and Cowtan, K. (2004) Acta Crystallogr. D60:2126-2132), final R_work and R_free values of 19.71% and 22.84% were obtained for the four independently crystallographically determined examples of the human AMCase polypeptide (amino acid residues 22-400) (see Table 3).

W2025-7029WO / AM102903-PCT

Table 3. Statistics for data collection and refinement for human AMCase polypeptide

Wavelength (A) 1.000

Resolution range of data (A) 50.0 - 2.0

Rmerge ^a (%) 12.7 (45.3)

Completeness (%) 97.9 (91.4)

Total reflections 343,748

Unique reflections 91,479

I/σ(I) 9.77 (2.04)

Resolution range of refinement (A) 30.0 - 2.0

Rwork (%) 19.71

Rfree (%) 22.84

RMS deviations from ideal geometry for:

Bonds (A) 0.008

Angles (°) 1.060 a Rmerge= Hh - <Ih>l / Ih, where <I_h> is the average intensity over symmetry equivalents. Numbers in parentheses reflect statistics for the last shell. R_Work= 11 Fobs I " IF_calcll / IF_ob_sl c R_free is equivalent to R_WOrk, but calculated for a randomly chosen 5% of reflections omitted from the refinement process.

Example 2: Crystallization and Resolution of Methylallosamidin-bound Human AMCase Co-crystals of human AMCase polypeptide and methylallosamidin were grown by hanging drop vapor diffusion at 18°C in drops containing 0.2 μl protein stock solution (21 mg/ml protein, 25 mM Tris pH 7.5, 50 mM NaCl, 1 mM methylallosamidin) and mixed with 0.2 μl well solution (20% PEG 3350, 200 mM Ammonium Formate) and equilibrated against 0.2 mL well solution. Slate-like crystals grew in about 1 week, and generally measured -80 microns, or micrometers, across.

Co-crystals of human AMCase polypeptide and methylallosamidin were drawn through a solution of 25% glycerol and 75% well solution, and cooled rapidly in liquid nitrogen. Diffraction data were recorded at Advanced Light Source Beamline 5.0.1 on a q-210 ccd camera (Berkeley, CA). Intensities were integrated and scaled using the programs Denzo and Scalepack (Otwinowski and Minor, 1997). The co-crystals belong to the space group Yl{∑{∑_\ unit cell parameters a = 63.69 A, b = 89.29 A, c = 126.69 A, α=β^γ = 90°, and contain two molecules of methylallosamidin-bound human AMCase polypeptide in the asymmetric unit, with a calculated solvent content of 39.7%. The W2025-7029WO / AM102903-PCT

amino acid range visible and modeled for the methylallosamidin-bound AMCase corresponded to amino acids 22-398 for both molecules A and B, as well as for the bound methylallosamidin.

The crystal structure of the co-crystals of human AMCase polypeptide and methylallosamidin was solved by molecular replacement using the crystal structure of the human AMCase polypeptide alone. The molecular replacement solution was refined using CNX (Brunger et al, 1998) and Refmac5 (CCP4), using Coot (Emsley, 2004) for model refinement. The final R_work and Rf_ree values were 17.48 % and 19.39 % for methylallosamidin-bound human AMCase polypeptide (see Table 4).

Table 4. Statistics for data collection and refinement of methylallosamidin-bound human AMCase polypeptide

Wavelength (A) 1.000

Resolution range of data (A) 20.0 - 1.7

Rmerge * (%) 0.101 (0.598)

Completeness (%) 90.0 (91.1)

Total reflections 406,206

Unique reflections 64,057

I/σ(I) 15.21 (2.1)

Resolution range of refinement (A) 20.0 - 1.7

Rwork (%) 17.48

Rfree (%) 19.39

RMS deviations from ideal geometry for:

Bonds (A) 0.008

Angles (°) 1.058 a Rmerge= Hh - <Ih>l / Ih, where <Ih> is the average intensity over symmetry equivalents. Numbers in parentheses reflect statistics for the last shell.

Rwork= 11 Fobs I " IFcalcll / I Fobs I c R_free is equivalent to R_WOrk, but calculated for a randomly chosen 5% of reflections omitted from the refinement process.

Molecular modeling

Models of alpha- and beta-chitopentose bound to AMCase, respectively, were generated using the docking program Glide and the MacroModel eMBrAcE minimization procedure in Maestro (Schrodinger, New York, NY, 2007). In a first step, one NAG unit was docked into the active site of the AMCase + MALLO protein structure using W2025-7029WO / AM102903-PCT

GlideSP version 4.5. Next, the structure of Chitinase B with a pentamer bound (van Aalten et al. 2001 Proc. Natl. Acad. ScL U. S. A. 98(16): 8979-84) (PDBID = 1E6N) was superimposed onto the AMCase + MALLO protein structure by aligning the sequences in Maestro. The +2 and +1 NAG units were built into the AMCase structure based on their positions in the Chitinase B structure and the -1 and -2 NAG units were added based on their position in the allosamidin bound to AMCase. Beta-chitopentose with central NAG unit in a boat-like conformation mimicking the transition state (van Aalten et al. 2001 supra.) was then minimized using eMBrAcE with the OPLS force field (Jorgensen et al. (1996) Journal of the American Chemical Society 118(45): 11225-11236) and implicit water solvent (Ghosh et al. (1998) /. Phys. Chem. B. 102: 10983-10990). More specifically, the substrate and all residues with an atom within 3 A of the ligand were subject to up to 1000 steps of full minimization, the next shell of residues within 5 A of the ligand was subject to harmonic constraints during the minimization, and a second shell of residues within 7 A were fixed.

Labeling with diethyl pyrocarbonate (DEPC) Difference Spectrum.

A large excess of DEPC, 200 microM was added to 1 microM AMCase and allowed to incubate for 10 to 15 minutes in a citric acid/phosphate buffer pH 6.9. The spectrum of unlabeled AMCase was compared to spectrum of labeled AMCase. A spectral change at 278 nm represents modifications of tyrosines while a spectral change at 242 nm represents modified histidines. Modified His has extinction coefficient of 3.2 xlO³ m^"1 cm^" . The change in absorbance at 242 nm is 0.059 AU, corresponding to 18 microM His labeled.

Inactivation Activity analysis.

The activity of AMCase was determined after incubation with varying amounts of DEPC (0 to 1000 microM). Inactivation was done at pH 6.9 with 0.75 microM AMCase in which the reaction was quenched by dilution (1:200) in buffer pH 6.0. Activity was measured with 30 microM substrate and change in activity (Ao/A) was plotted against ratio of DEPC to AMCase ([DEPC]/[AMCase]). Reaction time was 5 and 15 min. This W2025-7029WO / AM102903-PCT

shows that there is a 40% loss in AMCase activity after 15 min even at 1000 microM DEPC.

PH of inactivation.

5 This was done to confirm that the loss in activity seen was due to labeling of His.

The pK_a of the imidazole of His is 6.9, therefore the pH dependence of inactivation should mirror the pK_a of His. The inactivation assay was done with 0.75 microM AMCase and 200 microM DEPC at varying pH from 5.7 to 7.8 and quenched at different times from 0 to 15 min in assay buffer pH 6.0. The rate of inactivation at each pH was o determined and fit to the pH dependence equation (v = V_mαx/[l+10^Λ( pK_a -pH)]). The pK_a determined was 6.9 + 0.1, which corresponds to a His.

Effect of DEPC labeling on the kinetics of AMCase.

The kinetic constants of the di-sugar substrate were determined for labeled and 5 non-labeled AMCase. This will show what effect the labeling of AMCase has on the enzyme. In this labeling reaction 10 microM DEPC was used with 0.75 microM AMCase. The reaction was quenched by dilution and the kinetics was determined. Resulting data was plotted in a double-recipical plot and shows that there is an effect seen on V_max but not on K_1n. The values are for control (V_max = 380 + 38 RFU/min with a K_1n =0 11.1 + 3.1 microM) while the labeled AMCase (V_max = 153 + 11 RFU/min with a K_1n = 12.2 + 2.2 microM). This represents a loss in activity of -59%.

PH rate profile: Labeled versus unlabeled AMCase.

The pH dependence of the kinetic parameters was determined for the labeled and5 non-labeled AMCase. The samples were treated the same with the exception of the addition of 250 microM DEPC in the inactivation assay. The inactivation assay was performed at pH 6.9 and then quenched by dilution into buffer at varying pH (pH 2.8 to 7.3). The steady state kinetic parameters were then determined at each pH and the log V_max and log V/K were plotted against pH. There appears to be a "hollow" in the logV/K0 vs pH plot when the enzyme is labeled. The hollow appears on the ascending limb and typically suggest substrate stickiness. W2025-7029WO / AM102903-PCT

Example 3: Additional Co-Crystal Complexes of Human AMCase

Following the experimental procedures described in Examples 1 and 2, four additional co-crystallized complexes of ligand-bound human AMCase were generated. 5 The co-crystallized complexes were generated in about 20 to 25% PEG 3350 in several buffer conditions containing tris and ammonium based buffers. The particular experimental conditions are set forth in Figure 5 below and are described as follows:

Co-crystals of Compound 1 and AMCase were generated in 24.5% PEG 3350, 0.1 M solution of bis-tris pH 6.5. These co-crystals belong to space group V1{l_\λ_\ and have o unit cell parameters 45.2 x 81.5 x 91.9. They contain one molecule of Compound 1- bound human AMCase polypeptide in the asymmetric unit.

Co-crystals of Compound 2 and AMCase were generated in 20% PEG 3350, 0.2 M solution of Ammonium H₂PO₄. These co-crystals belong to space group P2i and have unit cell parameters 69.9 x 92.4 x 111.7 β=95.9. They contain four molecules of 5 Compound 2-bound human AMCase polypeptide in the asymmetric unit.

Co-crystals of Compound 3 and AMCase were generated in 20% PEG 3350, 0.2 M solution of Ammonium Fluoride. These co-crystals belong to space group V1{l{λ_\ and have unit cell parameters 45.3 x 81.9 x 91.7. They contain one molecule of Compound 3- bound human AMCase polypeptide in the asymmetric unit. 0 Co-crystals of Compound 4 and AMCase were generated in 20% PEG 3350, 0.2

M solution of di- Ammonium H citrate. These co-crystals belong to space group P2i and have unit cell parameters 69.9 x 93.3 x 87.2 β=106.92. They contain three molecules of Compound 4-bound human AMCase polypeptide in the asymmetric unit.

Therefore, Figure 5 provides crystallization conditions, and space groups and unit5 cell parameters for human AMCase in uncomplexed form (apo) and five ligand-bound forms of AMCase.

Example 4: High Resolution Analysis of the Structures of AMCase.

The structures of AMCase alone and in complex with the inhibitor 0 methylallosamidin were determined to high resolution (as described in Examples 1 and

3). The structure of AMCase was determined to a resolution of 2.0 A in the apo form and W2025-7029WO / AM102903-PCT

to 1.7 A in complex with methylallosamidin by molecular replacement using human chitotriosidase a search model. The construct that was successfully crystallized was a C- terminal truncation including the catalytic domain. The Ser residue originally at position 354 was mutated to Phe, a polymorphism that is at least as common as the Ser, to avoid N-linked glycosylation. The apo protein crystallized in space group P2i, and contains four molecules of AMCase in the asymmetric unit, implying a solvent content of 39.5%. The resulting map showed good electron density for the residues 22 to 400 (monomer A, B, C, and D, with the exception of AA 231-236 in molecule B). Residues C-terminal to 400, including the His tag, are not seen in the electron density maps and are presumably disordered. AMCase in complex with methylallosamidin crystallized in space group ¥2{l{lι_, and contains two molecules of AMCase in the asymmetric unit, implying a solvent content of 39.7%. The resulting map shows good electron density for residues 22 through 398 in both molecules A and B, as well as for the bound methylallosamidin (Figure 4). Residues C-terminal to 398, including the His tag, are not seen in the electron density maps and are presumably disordered

Overall structure and interaction with methylallosamidin

The structures of AMCase alone and in complex with the inhibitor methylallosamidin reveal an eight stranded beta-barrel structure (TIM-barrel) with an alpha/beta lobe inserted between beta-sheet 7 and alpha-helix I, that is composed of a 5- stranded anti-parallel beta sheet and an alpha-helix (Figure 3A). The overall tertiary structure is very similar to the structure of the related human chitotriosidase (Fusetti et al. 2002 /. Biol. Chem. 277(28): 25537-44; Rao et al. 2003 /. Biol. Chem. 278(22): 20110-6) (PDB accession codes IHKK, IGUV, ILGl, 1LG2). A long cleft which is lined with solvent-exposed aromatic residues, including Trp-71, Tyr-34, Trp-31, Trp-360, Trp-99, Trp-218, is the site of chitin binding (Fusetti et al. 2002, supra; Houston et al. 2002, supra; Rao et al. 2003, supra). In the liganded structure presented here, methylallosamidin is bound in part of this groove (Figures 3A and 3B). The active site is dominated by the acidic residues featuring the common chitinase motif DXXDXDXE (Figures 7 A and 7B). Disulfide bonds are observed between Cys-26 and Cys-51, Cys- 307 and Cys-372, and Cys-49 and Cys-394 of SEQ ID NO:4, amino acid numbers W2025-7029WO / AM102903-PCT

referred to hereinbelow are according to SEQ ID NO: 4). The disulfide bond between Cys-49 and Cys-394, which does not have an equivalent in chitotriosidase, affixes the C- terminal to the base of the beta-barrel (Figure 3A) and likely contributes to the overall stability of the catalytic domain. Allosamidin and its variant methylallosamidin are broad-spectrum natural product inhibitors. They are pseudo-trisaccharides with two NAG sugars coupled to allosamizoline. In the complex structure with methylallosamidin, the inhibitor is well defined, with the allosamizoline binding in the active site at the -1 subsite, and the attached NAG sugars reaching into the -2 and -3 subsites (Figures 3A, 3B, 7A and 7B). The methyl group, differentiating this inhibitor from allosamidin, is clearly seen in the electron density maps (Figure 4). As it is solvent-exposed and not making significant contacts with the protein, methylallosamidin is not expected to bind differently than allosamidin. An ordered water molecule (HOH-346 and HOH-84 for AMCase chains A and B) is observed 3.5 A from allosamizoline C17 and 2.8 A from Glu-140. This interaction mimics that of the water which effects the hydrolysis of the oxazolinium ion intermediate during the final step of chitin cleavage (van Aalten et al. 2001. Proc. Natl. Acad. ScL U.S.A. 98(16):8979-84).

In the apo AMCase structure, an invasion of the active site of one molecule by the C-terminal tail of a neighboring molecule was observed (Figure 8). There are four molecules in the crystallographic asymmetric unit, and the exact position taken on by the invading tail is slightly different between two molecules from the other two (molecules A and C are nearly identical, as are B and D). In either case, Gln-399 roughly occupies the -2 subsite and reaches towards the -1 subsites, and Pro-400 roughly occupies the -3 subsite. It is likely that this interaction is not physiologically relevant, but is a result of the packing in this particular crystal form.

Comparison of apo and methylallosamidin bound structures

Overall differences between APO and MALLO-bound structures are minimal in the alphaC trace, including a small movement around loop 98-102 (between beta-strand 3 and alpha-helix) which accommodates the movement of Asn-100 to form hydrogen- bonds with methylallosamidin in multiple places through both main chain and side chain W2025-7029WO / AM102903-PCT

atoms. A significant difference between these structures is the rotamer of Asp-138. In the unliganded enzyme, Asp-138 is in a rotamer that allows a hydrogen bond with Asp- 136. In the methylallosamidin-bound enzyme, the Asp-138 side chain swings nearly 180° around, breaking the bond with Asp- 136 and taking up a position within 2.6 A of Asp- 140 and forming H-bonds with Asp- 140 and methylallosamidin at the same time (Figure 7A). These alternative rotamers of equivalent Asp residues have been well documented in other chitinase structures. Furthermore there is a rotation of the Glu-140 side chain from the apo-structure where it is pointing towards the main chain N of Trp-99 (3.3 A) and the side chain hydroxyl of Tyr-141. Upon binding of methylallosamidin, Glu-140 rotates about 60 degrees to form hydrogen-bonds with Asp-138 and with the allosamizoline N. It is the protonation of Glu-140 that is the final step of chitin hydrolysis.

Preference for beta-anomer of substrate Models of alpha- and beta-chitopentose bound to AMCase, respectively, are in agreement with and provide an explanation for the previously reported preference of AMCase for the beta-anomer of the substrate. In the models the fourth and fifth N- acetyl glucosamine (NAG) units of chitopentose pack between Trp-99 and Trp-218 (Figure 9). The substrate +2 position is packing against Trp-218, and the +1 position NAG packs against Trp-99. This stacking presumably limits the mobility of this part of the substrate. In this position the terminal hydroxyl of the alpha anomer makes an unfavorable electrostatic interaction with the -NH of the indole ring of Trp-218, while the equatorial position of the terminal hydroxyl of the beta anomer does not. Based on the models, the interaction energy of beta-chitopentose with AMCase is 2.95 kcal/mol more favorable than that of the alpha-chitopentose.

Labeling Analysis.

In order to determine the role of the conserved histidines found within the active site of AMCase, labeling studies done with diethyl pyrocarbonate (DEPC) were initiated. DEPC is shown to react in a selective manner with histidines, but reactions with other amino acids, such as tyrosine, are possible. (Miles 1977) Difference spectrum of 1 DM W2025-7029WO / AM102903-PCT

AMCase and AMCase treated with DEPC show an increase in absorbance at 245 nm, a lack of a decrease in absorbance at 278 nm demonstrates that very few if any tyrosine are labeled. From these data it has been determined that ~3 histidines are labeled.

Treatment of AMCase with varying amounts of DEPC inactivated the enzyme, but complete loss of activity was not achieved. This lowering of AMCase activity without complete loss suggests that histidine is not essential for activity, but may be required for optimum activity at low pH. However, assays were done a pH range of 5 to 6. AMCase activity has been demonstrated at a pH of 3. Assays done at lower pH, such as 3 may give more incite into the function of the histidine at lower pH. The pH dependence on DEPC inactivation shows a pK_a of 6.9, which corresponds with an imidazole group of histidine. Kinetics analysis of AMCase that was labeled with DEPC show a decrease in V _max, consistent with activity data, but no change in the K_1n for the substrate, indicating that the observed lower activity is not due to interference in substrate binding. Together these enzymatic data support the conclusion that His-208 and His-269 are playing a role in the activity of this enzyme.

Comparison of AMCase and chitotriosidase: pH optimum

Although both AMCase and the other human chitinase, chitotriosidase, are secreted enzymes, only AMCase is implicated in asthma. Among the most notable differences between AMCase and human chitotriosidase are three residue differences near the active site. Two of these three residues, His-208 and His-269 of SEQ ID NO:4, are conserved in AMCase genes across species (Bussink et al., 2007 Genetics 177(2):959-70) but are different in human chitotriosidase, suggesting that they together have an important structural role in AMCases. One of these residues, His-208, has previously been proposed to have a role in determining the pH optimum of this enzyme (Bussink et al., 2008 FEBS Lett. 582(6): 931-5). Applicants believe that rather than this His alone, it is the three together that are in position to address the structural basis of AMCase' s low pH optimum as compared to chitotriosidase. It is well established that the pK_a values of active site residues can be modified by adjacent residues. Two additional resides are observed to influence the active site's key acidic residue system (the Asp-

138/Glu-140 system). His-208, His-269 and Arg-145 all contact key conserved residues W2025-7029WO / AM102903-PCT

within the active site and are in a position to change the pH optimum of the enzyme by influencing the pK_a of the Asp-138/Glu-140 system.

In both apo and liganded structures, AMCase His-208 is a hydrogen-bonding partner of the conserved Asp- 136 (Figures 6 and 7A), part of the DXXDXDXE (SEQ ID NO:5) motif common to all chitinases. By contrast, human chitotriosidase has an Asn at this position. Mutation of this His-208 to Asn in AMCase has been shown to play an important role in the acidic pH optimum of AMCase (Bussink et al. (2008) FEBS Lett. 582(6): 931-5)). These studies suggest that a protonated His in this position contributes to the destabilization of the Asp-136/Asp-138 H-bond, which must take place in order to allow the binding of substrate. The destabilization of this bond allows Asp- 138 to shuttle back and forth (rotating about the Calpha-Cbeta bond) between Asp- 136 in the unliganded enzyme and the catalytic GIu- 140 when methylallosamidin, and presumably substrate, is bound. Based on studies in ChiB (Synstad et al. 2004 Eur. J. Biochem. 271(2): 253-62), the pK_a of Asp-136 is extremely low, ensuring that Asp-138 carries the H as it swings from Asp-136 in the apo protein to Asp-138 in the liganded structure. The protonated GIu- 140 then participates in the cleavage at the beta(l,4) linkage between NAG sugars. In AMCase His-208 is 2.8/2.9 A from Asp-136 and is well within H- bonding range. While the position of chitotriosidase' s Asn-208 is very similar, the respective H donor and acceptor atoms slightly further apart 3.2/3.4 A apart. The other residues contacting Asp-136 are essentially identical between AMCase and chitotriosidase; H-bond donor groups from Tyr-27 and Thr-181 (Ser-181 in chito). His-269 has not previously been remarked upon, yet represents another key difference between AMCase and chitotriosidase. His-269 is observed to form a hydrogen-bond with Asp-213, a conserved and important residue in the active site (Figures 6 and 7A). Asp-213 lies on the bottom of the active site and coordinates the boat conformation of the substrate sugar in the -1 subsite by accepting a hydrogen bond from a hydroxyl of the substrate sugar in the -2 subsite, in preparation for hydrolysis. In studies in ChiB it has been shown to play a role in increasing the pK_a values in the Asp- 138/Glu-140 system (Synstad et al. 2004 Eur. J. Biochem. 271(2): 253-62). In the ChiB system, Asp-215 (the equivalent to 213 in AMCase) has a very low pK_a in part due to its salt-bridge with the Arg present in both the ChiB and chitotriosidase at the position W2025-7029WO / AM102903-PCT

equivalent to AMCase's 269. In AMCase we see replacement of this Arg with His-269, with the side chain N of His being positioned to H-bond with Asp-213 as the Arg side chain guanidyl group does. As a result of coordinating with a weaker base, the pK_a of Asp-213 is likely not as low. This consequently would render Asp-213 less able to increase the pK_a of the Asp-138/Glu-140 system. The net result of a lower pK_a in the Asp-138/Glu-140 system would be manifest as a lower pH optimum for activity. This amino acid change is likely to play a significant role in this difference between AMCase and other chitinases with pH optimums closer to neutral pH. In an alignment of vertebrate chitotriosidase and AMCase genes, His at this position tracks perfectly with low-pH optimum enzymes (Bussink et al. 2007 Genetics 177(2):959-70).

Another novel feature revealed by these structures is the packing of Arg- 145 side chain against Trp-99, one of the key aromatic residues coordinating substrate binding. The charged Arg- 145 side chain forms H-bonds with the main chain carbonyls of Trp-99 and Glu-140. Glu-140, Trp-99 and the neighboring Asn-100 of SEQ ID NO:4 in turn H- bond with methylallosamidin (and by extension, the substrate) in five separate places, transmitting the effects of Arg- 145 (Figure 7B). Having a strongly basic residue influencing these active site residues would have the effect of lowering the pK_a of the Asp-138/Glu-140 system, again lowering the optimal pH of the enzyme. By contrast, in human chitotriosidase the GIn at this position is not spatially within range to make these contacts; thus a water molecule makes the equivalent interactions with the exposed main chain atoms of these active site residues in that enzyme. The chitotriosidase gene of some other species, however, also have an Arg at this position (Bussink et al., 2007 Genetics 177(2):959-70). Thus, this residue most likely serves to modulate the pK_a of the Asp-138/Glu-140 system rather than being the primary determinant responsible for the pH optimum.

In conclusion, the high resolution structures of AMCase and AMCase in complex with methylallosamidin have been determined. These structures delineate the three- dimensional structure of this enzyme, enable structure based rational drug design, and has allowed further insights into the activity of this enzyme. The following amino acid residues of human AMCase polypeptide were experimentally determined by X-ray crystallographic structural analysis to be within 5 A W2025-7029WO / AM102903-PCT

of methylallosamidin in the methylallosamidin-bound human AMCase polypeptide crystal structure: TYR-27, TRP-31, PHE-58, ILE-69, GLU-70, GLY-97, GLY-98, TRP- 99, ASN-100, PHE-101, ASP-136, ASP-138, GLU-140, ALA-183, MET-210, TYR-212, ASP-213, TYR-267, ALA-295, LYS-296, GLU-297, ILE-300, MET-358, TRP-360, LEU-364 of Table 2.

Additionally, the following amino acid residues of human AMCase polypeptide were experimentally determined by X-ray crystallographic structural analysis to be within 10 A of methylallosamidin in the methylallosamidin-bound human AMCase polypeptide crystal structure (residues described above hereby included): THR-25, CYS -26, TYR-27, PHE-28, THR-29, ASN-30, TRP-31, ALA-32, GLN-33, TYR-34, ARG-35, ILE-55, TYR-56, ALA-57, PHE-58, ALA-59, GLY-60, THR-68, ILE-69, GLU-70, ASP-73, LEU-93, LEU-94, ALA-95, ILE-96, GLY-97, GLY-98, TRP-99, ASN-100, PHE-101, GLY-102, PHE-106, LEU-135, ASP-136, PHE-137, ASP-138, TRP-139, GLU-140, TYR-141, ARG-145, THR-181, ALA-182, ALA-183, VAL-184, ALA-185, ALA-186, ILE-207, HIS-208, VAL-209, MET-210, THR-211, TYR-212, ASP-213, LEU-214, HIS- 215, TRP-218, ASN-225, ILE-261, VAL-262, GLY-263, PHE-264, PRO-265, TYR-267, GLY-268, HIS-269, ASN-270, ALA-291, GLY-292, TYR-294, ALA-295, LYS-296, GLU-297, SER-298, GLY-299, ILE-300, TRP-301, ALA-302, TYR-303, GLU-305, ALA-357, MET-358, VAL-359, TRP-360, ALA-361, ILE-362, ASP-363, LEU-364, ASP-365 of Table 2.

It is believed that a triad of polar residues in the second-shell may modulate the highly conserved chitinase active site. An intricate network of hydrogen bonds linking surrounding charged residuesto the key active site acidic residues is observed. The derived contacts are consistent with amino acid residues HIS-208, HIS-269 and ARG-145 which may account for the low pH optimum of the enzyme.

A detailed analysis of the active site and comparison with the related enzyme chitotriosidase is presented herein. Three second-shell amino acid residues (His-208, His-269 and Arg-145 of SEQ ID NO:4) are believed to modulate the highly conserved chitinase active site, and to establish the low pH optimum of this enzyme. Enzymatic data supporting the model that these two histidines play a role in the activity of this enzyme is shown herein. Finally, the structural basis for the observed preference of the W2025-7029WO / AM102903-PCT

enzyme for the beta-anomer of the substrate has been elucidated (Chou et al.2006 Biochemistry 45(14): 4444-54), finding that the indole ring of Trp-218 of SEQ ID NO:4 has an unfavorable interaction with the terminal hydroxyl of alpha-pentose, but not with the terminal hydroxyl of beta-pentose. Together these findings elucidate the mechanism of achieving specificity for low pH while guarding an active site that is highly conserved among all chitinases, and broaden our understanding of this enzyme.

Table 1. Structure coordinates of a human AMCase polypeptide (SEQ ID NOs 8-10, 8,

8, respectively, in i order of appearance).

# Name Res. /Chain/Res # X Y Z Occ. B Element

ATOM 1 N TYR A 22 46.103 -21.348 1.967 1.00 11.64 N

ATOM 2 CA TYR A 22 47.434 -20.887 2.461 1.00 11.34 C

ATOM 3 CB TYR A 22 48.534 -21.884 2.067 1.00 11.69 C

ATOM 4 CG TYR A 22 48.371 -23.247 2.694 1.00 11.66 C

ATOM 5 CDl TYR A 22 47.723 -24.274 2.012 1.00 11.66 C

ATOM 6 CEl TYR A 22 47.558 -25.527 2.591 1.00 11.90 C

ATOM 7 CZ TYR A 22 48.050 -25.761 3.862 1.00 12.01 C

ATOM 8 OH TYR A 22 47.890 -27.004 4.434 1.00 12.69 O

ATOM 9 CE2 TYR A 22 48.702 -24.756 4.563 1.00 11.27 C

ATOM 10 CD2 TYR A 22 48.859 -23.508 3.976 1.00 11.33 C

ATOM 11 C TYR A 22 47.792 -19.504 1.926 1.00 11.10 C

ATOM 12 O TYR A 22 47.288 -19.080 0.884 1.00 10.88 O

ATOM 13 N GLN A 23 48.679 -18.816 2.644 1.00 10.52 N

ATOM 14 CA GLN A 23 49.185 -17.517 2.218 1.00 10.19 C

ATOM 15 CB GLN A 23 49.227 -16.528 3.392 1.00 10.38 C

ATOM 16 CG GLN A 23 47.873 -16.231 4.051 1.00 12.41 C

ATOM 17 CD GLN A 23 46.862 -15.613 3.096 1.00 14.76 C

ATOM 18 OEl GLN A 23 47.222 -14.851 2.199 1.00 16.70 O

ATOM 19 NE2 GLN A 23 45.584 -15.935 3.293 1.00 15.93 N

ATOM 20 C GLN A 23 50.580 -17.665 1.622 1.00 9.27 C

ATOM 21 O GLN A 23 51.365 -18.507 2.061 1.00 8.59 O

ATOM 22 N LEU A 24 50.870 -16.852 0.614 1.00 8.56 N

ATOM 23 CA LEU A 24 52.226 -16.731 0.079 1.00 8.45 C

ATOM 24 CB LEU A 24 52.375 -17.431 -1.278 1.00 8.30 C

ATOM 25 CG LEU A 24 53.721 -17.296 -2.014 1.00 8.39 C

ATOM 26 CDl LEU A 24 54.888 -17.820 -1.178 1.00 8.18 C

ATOM 27 CD2 LEU A 24 53.685 -17.996 -3.377 1.00 8.58 C

ATOM 28 C LEU A 24 52.585 -15.250 -0.011 1.00 7.93 C

ATOM 29 O LEU A 24 52.093 -14.518 -0.869 1.00 7.83 O

ATOM 30 N THR A 25 53.461 -14.840 0.892 1.00 7.83 N

ATOM 31 CA THR A 25 53.763 -13.445 1.139 1.00 7.51 C

ATOM 32 CB THR A 25 53.578 -13.144 2.648 1.00 7.60 C

ATOM 33 OGl THR A 25 52.204 -13.352 3.006 1.00 7.00 O

ATOM 34 CG2 THR A 25 53.980 -11.732 2.989 1.00 7.80 C

ATOM 35 C THR A 25 55.185 -13.157 0.670 1.00 7.73 C

ATOM 36 O THR A 25 56.141 -13.771 1.145 1.00 7.81 O

ATOM 37 N CYS A 26 55.317 -12.235 -0.276 1.00 7.33 N

ATOM 38 CA CYS A 26 56.602 -11.966 -0.906 1.00 7.26 C

ATOM 39 CB CYS A 26 56.516 -12.244 -2.412 1.00 7.49 C

ATOM 40 SG CYS A 26 55.918 -13.922 -2.798 1.00 8.94 S

ATOM 41 C CYS A 26 57.095 -10.541 -0.631 1.00 6.83 C

ATOM 42 O CYS A 26 56.432 -9.555 -0.989 1.00 6.37 O W2025-7029WO / AM102903-PCT

ATOM 43 N TYR A 27 58.261 -10.451 0.008 1.00 6.11 N

ATOM 44 CA TYR A 27 58.901 -9.164 0.290 1.00 5.63 C

ATOM 45 CB TYR A 27 59.906 -9.289 1.448 1.00 5.51 C

ATOM 46 CG TYR A 27 59.296 -9.355 2.841 1.00 5.88 C

ATOM 47 CDl TYR A 27 59.105 -8.192 3.597 1.00 5.64 C

ATOM 48 CEl TYR A 27 58.542 -8.247 4.875 1.00 5.18 C

ATOM 49 CZ TYR A 27 58.169 -9.477 5.410 1.00 6.08 C

ATOM 50 OH TYR A 27 57.619 -9.539 6.672 1.00 5.54 O

ATOM 51 CE2 TYR A 27 58.351 -10.647 4.680 1.00 4.81 C

ATOM 52 CD2 TYR A 27 58.914 -10.580 3.405 1.00 5.11 C

ATOM 53 C TYR A 27 59.620 -8.650 -0.954 1.00 5.27 C

ATOM 54 O TYR A 27 60.407 -9.376 -1.564 1.00 5.06 O

ATOM 55 N PHE A 28 59.321 -7.405 -1.325 1.00 5.20 N

ATOM 56 CA PHE A 28 60.045 -6.667 -2.365 1.00 5.08 C

ATOM 57 CB PHE A 28 59.064 -5.990 -3.333 1.00 5.03 C

ATOM 58 CG PHE A 28 59.658 -4.833 -4.110 1.00 4.90 C

ATOM 59 CDl PHE A 28 60.355 -5.054 -5.301 1.00 3.95 C

ATOM 60 CEl PHE A 28 60.898 -3.984 -6.026 1.00 3.54 C

ATOM 61 CZ PHE A 28 60.749 -2.683 -5.556 1.00 4.91 C

ATOM 62 CE2 PHE A 28 60.049 -2.451 -4.371 1.00 4.96 C

ATOM 63 CD2 PHE A 28 59.504 -3.522 -3.659 1.00 4.46 C

ATOM 64 C PHE A 28 60.896 -5.611 -1.679 1.00 4.91 C

ATOM 65 O PHE A 28 60.429 -4.952 -0.748 1.00 4.79 O

ATOM 66 N THR A 29 62.137 -5.445 -2.136 1.00 4.88 N

ATOM 67 CA THR A 29 63.055 -4.498 -1.498 1.00 4.96 C

ATOM 68 CB THR A 29 64.348 -5.189 -1.010 1.00 5.21 C

ATOM 69 OGl THR A 29 65.122 -5.635 -2.130 1.00 5.39 O

ATOM 70 CG2 THR A 29 64.011 -6.387 -0.108 1.00 4.99 C

ATOM 71 C THR A 29 63.378 -3.298 -2.390 1.00 4.95 C

ATOM 72 O THR A 29 63.733 -3.457 -3.558 1.00 4.70 O

ATOM 73 N ASN A 30 63.263 -2.097 -1.823 1.00 5.12 N

ATOM 74 CA ASN A 30 63.409 -0.866 -2.603 1.00 5.35 C

ATOM 75 CB ASN A 30 62.664 0.317 -1.942 1.00 5.23 C

ATOM 76 CG ASN A 30 63.251 0.737 -0.581 1.00 5.24 C

ATOM 77 ODl ASN A 30 64.210 0.148 -0.072 1.00 3.99 O

ATOM 78 ND2 ASN A 30 62.654 1.769 0.012 1.00 4.96 N

ATOM 79 C ASN A 30 64.854 -0.508 -2.980 1.00 5.68 C

ATOM 80 O ASN A 30 65.090 0.536 -3.592 1.00 6.03 O

ATOM 81 N TRP A 31 65.810 -1.371 -2.625 1.00 5.90 N

ATOM 82 CA TRP A 31 67.213 -1.167 -3.011 1.00 6.04 C

ATOM 83 CB TRP A 31 68.159 -1.304 -1.809 1.00 5.91 C

ATOM 84 CG TRP A 31 68.149 -2.652 -1.132 1.00 5.61 C

ATOM 85 CDl TRP A 31 68.940 -3.724 -1.429 1.00 5.63 C

ATOM 86 NEl TRP A 31 68.654 -4.775 -0.590 1.00 5.79 N

ATOM 87 CE2 TRP A 31 67.663 -4.395 0.277 1.00 5.54 C

ATOM 88 CD2 TRP A 31 67.322 -3.057 -0.031 1.00 5.37 C

ATOM 89 CE3 TRP A 31 66.317 -2.425 0.718 1.00 5.49 C

ATOM 90 CZ3 TRP A 31 65.697 -3.140 1.749 1.00 5.36 C

ATOM 91 CH2 TRP A 31 66.061 -4.469 2.033 1.00 5.29 C

ATOM 92 CZ2 TRP A 31 67.043 -5.112 1.310 1.00 5.53 C

ATOM 93 C TRP A 31 67.661 -2.060 -4.175 1.00 6.21 C

ATOM 94 O TRP A 31 68.753 -1.879 -4.717 1.00 6.18 O

ATOM 95 N ALA A 32 66.805 -3.007 -4.561 1.00 6.55 N

ATOM 96 CA ALA A 32 67.061 -3.893 -5.704 1.00 6.62 C

ATOM 97 CB ALA A 32 66.033 -5.010 -5.751 1.00 6.35 C

ATOM 98 C ALA A 32 67.104 -3.143 -7.040 1.00 6.80 C

ATOM 99 O ALA A 32 67.697 -3.624 -8.009 1.00 6.57 O

ATOM 100 N GLN A 33 66.471 -1.970 -7.079 1.00 7.24 N

ATOM 101 CA GLN A 33 66.554 -1.048 -8.219 1.00 7.57 C

ATOM 102 CB GLN A 33 65.724 0.217 -7.939 1.00 7.42 C

ATOM 103 CG GLN A 33 66.224 1.081 -6.777 1.00 7.47 C

ATOM 104 CD GLN A 33 65.531 2.440 -6.712 1.00 7.96 C

ATOM 105 OEl GLN A 33 65.530 3.199 -7.686 1.00 9.86 O W2025-7029WO / AM102903-PCT

ATOM 106 NE2 GLN A 33 64.946 2.754 -5.559 1.00 6.94 N

ATOM 107 C GLN A 33 67.996 -0.654 -8.622 1.00 7.84 C

ATOM 108 O GLN A 33 68.249 -0.296 -9.774 1.00 7.32 O

ATOM 109 N TYR A 34 68.929 -0.714 -7.672 1.00 8.34 N

ATOM 110 CA TYR A 34 70.296 -0.237 -7.916 1.00 8.99 C

ATOM 111 CB TYR A 34 70.871 0.437 -6.660 1.00 9.07 C

ATOM 112 CG TYR A 34 70.020 1.594 -6.189 1.00 9.44 C

ATOM 113 CDl TYR A 34 69.801 2.698 -7.015 1.00 9.65 C

ATOM 114 CEl TYR A 34 69.008 3.764 -6.600 1.00 9.84 C

ATOM 115 CZ TYR A 34 68.426 3.739 -5.346 1.00 9.45 C

ATOM 116 OH TYR A 34 67.648 4.804 -4.954 1.00 9.51 O

ATOM 117 CE2 TYR A 34 68.623 2.654 -4.501 1.00 9.78 C

ATOM 118 CD2 TYR A 34 69.420 1.581 -4.929 1.00 9.61 C

ATOM 119 C TYR A 34 71.258 -1.284 -8.470 1.00 9.17 C

ATOM 120 O TYR A 34 72.394 -0.955 -8.820 1.00 9.79 O

ATOM 121 N ARG A 35 70.799 -2.528 -8.580 1.00 9.35 N

ATOM 122 CA ARG A 35 71.641 -3.625 -9.077 1.00 9.35 C

ATOM 123 CB ARG A 35 71.040 -4.988 -8.697 1.00 9.47 C

ATOM 124 CG ARG A 35 70.807 -5.131 -7.199 1.00 9.26 C

ATOM 125 CD ARG A 35 70.299 -6.501 -6.770 1.00 9.08 C

ATOM 126 NE ARG A 35 70.170 -6.531 -5.314 1.00 8.80 N

ATOM 127 CZ ARG A 35 69.204 -7.142 -4.632 1.00 8.44 C

ATOM 128 NHl ARG A 35 68.233 -7.811 -5.255 1.00 8.01 N

ATOM 129 NH2 ARG A 35 69.211 -7.078 -3.311 1.00 7.21 N

ATOM 130 C ARG A 35 71.860 -3.512 -10.589 1.00 9.30 C

ATOM 131 O ARG A 35 70.948 -3.112 -11.317 1.00 9.39 O

ATOM 132 N PRO A 36 73.075 -3.847 -11.064 1.00 9.14 N

ATOM 133 CA PRO A 36 73.404 -3.707 -12.485 1.00 9.17 C

ATOM 134 CB PRO A 36 74.926 -3.885 -12.504 1.00 9.05 C

ATOM 135 CG PRO A 36 75.201 -4.796 -11.340 1.00 9.06 C

ATOM 136 CD PRO A 36 74.215 -4.368 -10.281 1.00 9.14 C

ATOM 137 C PRO A 36 72.751 -4.753 -13.396 1.00 9.31 C

ATOM 138 O PRO A 36 72.467 -5.872 -12.957 1.00 9.32 O

ATOM 139 N GLY A 37 72.529 -4.375 -14.655 1.00 9.22 N

ATOM 140 CA GLY A 37 72.056 -5.292 -15.695 1.00 9.32 C

ATOM 141 C GLY A 37 70.858 -6.130 -15.299 1.00 9.49 C

ATOM 142 O GLY A 37 69.841 -5.602 -14.841 1.00 9.52 O

ATOM 143 N LEU A 38 70.998 -7.445 -15.444 1.00 9.79 N

ATOM 144 CA LEU A 38 69.907 -8.385 -15.177 1.00 9.83 C

ATOM 145 CB LEU A 38 70.242 -9.778 -15.733 1.00 9.84 C

ATOM 146 CG LEU A 38 70.365 -9.975 -17.253 1.00 10.40 C

ATOM 147 CDl LEU A 38 70.915 -11.353 -17.566 1.00 10.40 C

ATOM 148 CD2 LEU A 38 69.041 -9.763 -17.980 1.00 11.09 C

ATOM 149 C LEU A 38 69.504 -8.481 -13.701 1.00 9.74 C

ATOM 150 O LEU A 38 68.521 -9.139 -13.374 1.00 10.00 O

ATOM 151 N GLY A 39 70.248 -7.818 -12.822 1.00 9.77 N

ATOM 152 CA GLY A 39 69.935 -7.800 -11.391 1.00 9.96 C

ATOM 153 C GLY A 39 68.903 -6.761 -10.973 1.00 9.91 C

ATOM 154 O GLY A 39 68.247 -6.913 -9.939 1.00 9.98 O

ATOM 155 N ARG A 40 68.764 -5.703 -11.771 1.00 9.78 N

ATOM 156 CA ARG A 40 67.801 -4.638 -11.494 1.00 9.75 C

ATOM 157 CB ARG A 40 67.866 -3.553 -12.573 1.00 9.91 C

ATOM 158 CG ARG A 40 66.937 -2.364 -12.349 1.00 10.97 C

ATOM 159 CD ARG A 40 67.265 -1.259 -13.349 1.00 13.54 C

ATOM 160 NE ARG A 40 66.213 -0.248 -13.467 1.00 14.61 N

ATOM 161 CZ ARG A 40 66.113 0.837 -12.702 1.00 15.74 C

ATOM 162 NHl ARG A 40 65.124 1.699 -12.903 1.00 14.27 N

ATOM 163 NH2 ARG A 40 66.992 1.062 -11.733 1.00 15.94 N

ATOM 164 C ARG A 40 66.391 -5.208 -11.396 1.00 9.27 C

ATOM 165 O ARG A 40 65.937 -5.916 -12.296 1.00 8.96 O

ATOM 166 N PHE A 41 65.720 -4.905 -10.286 1.00 8.92 N

ATOM 167 CA PHE A 41 64.362 -5.384 -10.037 1.00 8.60 C

ATOM 168 CB PHE A 41 64.365 -6.506 -8.989 1.00 8.31 C W2025-7029WO / AM102903-PCT

ATOM 169 CG PHE A 41 63.066 -7.274 -8.901 1.00 8.51 C

ATOM 170 CDl PHE A 41 62.959 -8.543 -9.455 1.00 8.60 C

ATOM 171 CEl PHE A 41 61.763 -9.264 -9.376 1.00 9.11 C

ATOM 172 CZ PHE A 41 60.661 -8.712 -8.724 1.00 7.88 C

ATOM 173 CE2 PHE A 41 60.759 -7.443 -8.162 1.00 8.16 C

ATOM 174 CD2 PHE A 41 61.957 -6.734 -8.248 1.00 8.02 C

ATOM 175 C PHE A 41 63.479 -4.218 -9.595 1.00 8.57 C

ATOM 176 O PHE A 41 63.736 -3.573 -8.572 1.00 8.31 O

ATOM 177 N MET A 42 62.447 -3.955 -10.390 1.00 8.46 N

ATOM 178 CA MET A 42 61.491 -2.881 -10.130 1.00 8.85 C

ATOM 179 CB MET A 42 61.397 -1.951 -11.347 1.00 8.65 C

ATOM 180 CG MET A 42 62.745 -1.392 -11.818 1.00 10.24 C

ATOM 181 SD MET A 42 63.540 -0.341 -10.587 1.00 12.93 S

ATOM 182 CE MET A 42 62.505 1.115 -10.670 1.00 12.16 C

ATOM 183 C MET A 42 60.125 -3.497 -9.812 1.00 8.62 C

ATOM 184 O MET A 42 59.921 -4.684 -10.064 1.00 8.64 O

ATOM 185 N PRO A 43 59.190 -2.704 -9.249 1.00 8.58 N

ATOM 186 CA PRO A 43 57.870 -3.267 -8.932 1.00 8.85 C

ATOM 187 CB PRO A 43 57.066 -2.038 -8.483 1.00 8.53 C

ATOM 188 CG PRO A 43 58.111 -1.134 -7.896 1.00 8.61 C

ATOM 189 CD PRO A 43 59.282 -1.289 -8.843 1.00 8.50 C

ATOM 190 C PRO A 43 57.203 -3.979 -10.115 1.00 9.16 C

ATOM 191 O PRO A 43 56.591 -5.028 -9.925 1.00 8.89 O

ATOM 192 N ASP A 44 57.346 -3.432 -11.322 1.00 9.70 N

ATOM 193 CA ASP A 44 56.746 -4.032 -12.518 1.00 10.21 C

ATOM 194 CB ASP A 44 56.702 -3.017 -13.669 1.00 10.81 C

ATOM 195 CG ASP A 44 55.628 -1.955 -13.469 1.00 12.56 C

ATOM 196 ODl ASP A 44 54.445 -2.320 -13.288 1.00 14.35 O

ATOM 197 OD2 ASP A 44 55.966 -0.753 -13.495 1.00 14.31 O

ATOM 198 C ASP A 44 57.371 -5.366 -12.972 1.00 10.11 C

ATOM 199 O ASP A 44 56.867 -6.007 -13.899 1.00 10.08 O

ATOM 200 N ASP A 45 58.453 -5.790 -12.320 1.00 9.97 N

ATOM 201 CA ASP A 45 59.032 -7.119 -12.575 1.00 9.88 C

ATOM 202 CB ASP A 45 60.543 -7.115 -12.296 1.00 9.87 C

ATOM 203 CG ASP A 45 61.297 -6.154 -13.203 1.00 10.09 C

ATOM 204 ODl ASP A 45 61.021 -6.163 -14.416 1.00 8.90 O

ATOM 205 OD2 ASP A 45 62.144 -5.380 -12.702 1.00 9.44 O

ATOM 206 C ASP A 45 58.342 -8.222 -11.764 1.00 9.88 C

ATOM 207 O ASP A 45 58.633 -9.410 -11.936 1.00 9.84 O

ATOM 208 N ILE A 46 57.426 -7.823 -10.885 1.00 9.62 N

ATOM 209 CA ILE A 46 56.659 -8.777 -10.080 1.00 9.49 C

ATOM 210 CB ILE A 46 56.127 -8.119 -8.777 1.00 9.60 C

ATOM 211 CGl ILE A 46 57.298 -7.646 -7.898 1.00 9.08 C

ATOM 212 CDl ILE A 46 56.894 -6.791 -6.699 1.00 9.00 C

ATOM 213 CG2 ILE A 46 55.203 -9.078 -8.016 1.00 8.97 C

ATOM 214 C ILE A 46 55.485 -9.326 -10.890 1.00 10.01 C

ATOM 215 O ILE A 46 54.694 -8.553 -11.446 1.00 9.80 O

ATOM 216 N ASN A 47 55.391 -10.654 -10.971 1.00 10.24 N

ATOM 217 CA ASN A 47 54.197 -11.318 -11.494 1.00 10.64 C

ATOM 218 CB ASN A 47 54.502 -12.798 -11.787 1.00 10.71 C

ATOM 219 CG ASN A 47 53.329 -13.546 -12.431 1.00 12.46 C

ATOM 220 ODl ASN A 47 52.158 -13.212 -12.234 1.00 12.79 O

ATOM 221 ND2 ASN A 47 53.653 -14.583 -13.196 1.00 13.65 N

ATOM 222 C ASN A 47 53.064 -11.171 -10.465 1.00 10.41 C

ATOM 223 O ASN A 47 53.147 -11.735 -9.369 1.00 10.10 O

ATOM 224 N PRO A 48 52.006 -10.404 -10.810 1.00 10.49 N

ATOM 225 CA PRO A 48 50.907 -10.128 -9.865 1.00 10.55 C

ATOM 226 CB PRO A 48 49.979 -9.197 -10.656 1.00 10.56 C

ATOM 227 CG PRO A 48 50.338 -9.418 -12.093 1.00 10.79 C

ATOM 228 CD PRO A 48 51.791 -9.741 -12.110 1.00 10.36 C

ATOM 229 C PRO A 48 50.141 -11.365 -9.406 1.00 10.62 C

ATOM 230 O PRO A 48 49.469 -11.322 -8.369 1.00 10.34 O

ATOM 231 N CYS A 49 50.249 -12.454 -10.167 1.00 10.97 N W2025-7029WO / AM102903-PCT

ATOM 232 CA CYS A 49 49.527 -13.685 -9.854 1.00 10.86 C

ATOM 233 CB CYS A 49 48.919 -14.286 -11.120 1.00 11.16 C

ATOM 234 SG CYS A 49 47.489 -15.324 -10.788 1.00 12.41 S

ATOM 235 C CYS A 49 50.384 -14.729 -9.137 1.00 10.57 C

ATOM 236 O CYS A 49 49.945 -15.865 -8.931 1.00 10.72 O

ATOM 237 N LEU A 50 51.595 -14.343 -8.746 1.00 9.88 N

ATOM 238 CA LEU A 50 52.525 -15.272 -8.120 1.00 9.62 C

ATOM 239 CB LEU A 50 53.971 -14.861 -8.417 1.00 9.72 C

ATOM 240 CG LEU A 50 55.108 -15.730 -7.880 1.00 9.89 C

ATOM 241 CDl LEU A 50 55.185 -17.059 -8.623 1.00 11.21 C

ATOM 242 CD2 LEU A 50 56.430 -14.968 -7.995 1.00 10.04 C

ATOM 243 C LEU A 50 52.294 -15.424 -6.612 1.00 9.24 C

ATOM 244 O LEU A 50 52.236 -16.551 -6.103 1.00 9.34 O

ATOM 245 N CYS A 51 52.157 -14.297 -5.909 1.00 8.40 N

ATOM 246 CA CYS A 51 51.994 -14.293 -4.449 1.00 8.04 C

ATOM 247 CB CYS A 51 53.075 -13.414 -3.796 1.00 7.85 C

ATOM 248 SG CYS A 51 54.758 -13.681 -4.452 1.00 8.26

ATOM 249 C CYS A 51 50.588 -13.818 -4.038 1.00 7.77 C

ATOM 250 O CYS A 51 49.884 -13.197 -4.830 1.00 7.57 O

ATOM 251 N THR A 52 50.183 -14.122 -2.808 1.00 7.76 N

ATOM 252 CA THR A 52 48.888 -13.653 -2.288 1.00 7.67 C

ATOM 253 CB THR A 52 48.240 -14.664 -1.305 1.00 7.91 C

ATOM 254 OGl THR A 52 49.070 -14.825 -0.147 1.00 8.16 O

ATOM 255 CG2 THR A 52 48.027 -16.025 -1.971 1.00 7.79 C

ATOM 256 C THR A 52 49.021 -12.294 -1.602 1.00 7.44 C

ATOM 257 O THR A 52 48.092 -11.481 -1.625 1.00 7.82 O

ATOM 258 N HIS A 53 50.171 -12.072 -0.971 1.00 7.03 N

ATOM 259 CA HIS A 53 50.495 -10.811 -0.315 1.00 6.77 C

ATOM 260 CB HIS A 53 50.581 -11.000 1.206 1.00 6.82 C

ATOM 261 CG HIS A 53 49.259 -11.210 1.882 1.00 7.70 C

ATOM 262 NDl HIS A 53 48.125 -11.610 1.212 1.00 9.92 N

ATOM 263 CEl HIS A 53 47.123 -11.721 2.066 1.00 9.07 C

ATOM 264 NE2 HIS A 53 47.572 -11.427 3.270 1.00 8.99 N

ATOM 265 CD2 HIS A 53 48.907 -11.116 3.184 1.00 8.44 C

ATOM 266 C HIS A 53 51.849 -10.326 -0.825 1.00 6.23 C

ATOM 267 O HIS A 53 52.753 -11.132 -1.044 1.00 6.06 O

ATOM 268 N LEU A 54 51.979 -9.014 -1.016 1.00 5.95 N

ATOM 269 CA LEU A 54 53.275 -8.389 -1.307 1.00 5.84 C

ATOM 270 CB LEU A 54 53.299 -7.773 -2.711 1.00 5.94 C

ATOM 271 CG LEU A 54 53.106 -8.680 -3.934 1.00 5.82 C

ATOM 272 CDl LEU A 54 52.928 -7.834 -5.182 1.00 5.46 C

ATOM 273 CD2 LEU A 54 54.265 -9.648 -4.114 1.00 6.35 C

ATOM 274 C LEU A 54 53.612 -7.329 -0.255 1.00 5.75 C

ATOM 275 O LEU A 54 52.756 -6.529 0.129 1.00 5.60 O

ATOM 276 N ILE A 55 54.857 -7.340 0.216 1.00 5.57 N

ATOM 277 CA ILE A 55 55.298 -6.407 1.256 1.00 5.44 C

ATOM 278 CB ILE A 55 55.669 -7.123 2.583 1.00 5.46 C

ATOM 279 CGl ILE A 55 54.511 -8.005 3.069 1.00 5.39 C

ATOM 280 CDl ILE A 55 54.770 -8.687 4.403 1.00 5.33 C

ATOM 281 CG2 ILE A 55 56.040 -6.097 3.666 1.00 5.20 C

ATOM 282 C ILE A 55 56.481 -5.579 0.761 1.00 5.55 C

ATOM 283 O ILE A 55 57.479 -6.129 0.290 1.00 5.54 O

ATOM 284 N TYR A 56 56.347 -4.256 0.885 1.00 5.17 N

ATOM 285 CA TYR A 56 57.342 -3.295 0.435 1.00 4.93 C

ATOM 286 CB TYR A 56 56.615 -2.032 -0.036 1.00 5.07 C

ATOM 287 CG TYR A 56 57.435 -1.043 -0.839 1.00 5.16 C

ATOM 288 CDl TYR A 56 57.217 -0.892 -2.206 1.00 5.39 C

ATOM 289 CEl TYR A 56 57.947 0.021 -2.958 1.00 5.78 C

ATOM 290 CZ TYR A 56 58.907 0.807 -2.341 1.00 6.09 C

ATOM 291 OH TYR A 56 59.613 1.703 -3.099 1.00 5.50 O

ATOM 292 CE2 TYR A 56 59.144 0.696 -0.976 1.00 5.46 C

ATOM 293 CD2 TYR A 56 58.399 -0.228 -0.229 1.00 6.00 C

ATOM 294 C TYR A 56 58.315 -2.955 1.573 1.00 4.70 C W2025-7029WO / AM102903-PCT

ATOM 295 O TYR A 56 57.923 -2.375 2.585 1.00 4.42 O

ATOM 296 N ALA A 57 59.584 -3.312 1.397 1.00 4.71 N

ATOM 297 CA ALA A 57 60.621 -3.004 2.388 1.00 5.14 C

ATOM 298 CB ALA A 57 61.403 -4.271 2.727 1.00 5.34 C

ATOM 299 C ALA A 57 61.559 -1.921 1.840 1.00 5.19 C

ATOM 300 O ALA A 57 62.067 -2.075 0.731 1.00 5.29 O

ATOM 301 N PHE A 58 61.800 -0.822 2.564 1.00 5.79 N

ATOM 302 CA PHE A 58 61.240 -0.497 3.877 1.00 6.09 C

ATOM 303 CB PHE A 58 62.317 -0.648 4.971 1.00 5.85 C

ATOM 304 CG PHE A 58 62.694 -2.075 5.288 1.00 6.03 C

ATOM 305 CDl PHE A 58 63.922 -2.591 4.876 1.00 5.88 C

ATOM 306 CEl PHE A 58 64.283 -3.908 5.175 1.00 5.77 C

ATOM 307 CZ PHE A 58 63.401 -4.728 5.902 1.00 5.48 C

ATOM 308 CE2 PHE A 58 62.179 -4.221 6.325 1.00 5.25 C

ATOM 309 CD2 PHE A 58 61.832 -2.895 6.019 1.00 5.43 C

ATOM 310 C PHE A 58 60.784 0.970 3.888 1.00 6.53 C

ATOM 311 O PHE A 58 61.240 1.780 3.068 1.00 6.81 O

ATOM 312 N ALA A 59 59.897 1.301 4.826 1.00 6.69 N

ATOM 313 CA ALA A 59 59.611 2.687 5.191 1.00 6.95 C

ATOM 314 CB ALA A 59 58.134 2.863 5.516 1.00 6.91 C

ATOM 315 C ALA A 59 60.468 3.100 6.391 1.00 7.01 C

ATOM 316 O ALA A 59 60.955 2.249 7.136 1.00 6.86 O

ATOM 317 N GLY A 60 60.650 4.405 6.572 1.00 7.32 N

ATOM 318 CA GLY A 60 61.418 4.924 7.708 1.00 7.87 C

ATOM 319 C GLY A 60 60.568 5.708 8.691 1.00 8.26 C

ATOM 320 O GLY A 60 59.344 5.550 8.736 1.00 8.10 O

ATOM 321 N MET A 61 61.218 6.559 9.479 1.00 8.68 N

ATOM 322 CA MET A 61 60.525 7.352 10.491 1.00 9.28 C

ATOM 323 CB MET A 61 60.444 6.572 11.811 1.00 9.15 C

ATOM 324 CG MET A 61 59.396 7.078 12.796 1.00 9.34 C

ATOM 325 SD MET A 61 59.530 6.316 14.427 1.00 9.96 S

ATOM 326 CE MET A 61 59.041 4.634 14.050 1.00 9.38 C

ATOM 327 C MET A 61 61.235 8.687 10.707 1.00 9.70 C

ATOM 328 O MET A 61 62.465 8.740 10.725 1.00 9.56 O

ATOM 329 N GLN A 62 60.446 9.755 10.846 1.00 10.27 N

ATOM 330 CA GLN A 62 60.932 11.086 11.223 1.00 10.99 C

ATOM 331 CB GLN A 62 61.051 12.013 10.008 1.00 11.19 C

ATOM 332 CG GLN A 62 62.263 11.782 9.112 1.00 12.11 C

ATOM 333 CD GLN A 62 62.294 12.739 7.921 1.00 12.11 C

ATOM 334 OEl GLN A 62 62.025 13.938 8.062 1.00 13.29 O

ATOM 335 NE2 GLN A 62 62.603 12.207 6.740 1.00 12.90 N

ATOM 336 C GLN A 62 59.939 11.697 12.200 1.00 11.06 C

ATOM 337 O GLN A 62 58.746 11.771 11.901 1.00 10.89 O

ATOM 338 N ASN A 63 60.434 12.139 13.356 1.00 11.40 N

ATOM 339 CA ASN A 63 59.596 12.740 14.408 1.00 11.84 C

ATOM 340 CB ASN A 63 59.241 14.205 14.075 1.00 12.22 C

ATOM 341 CG ASN A 63 60.473 15.109 13.964 1.00 13.48 C

ATOM 342 ODl ASN A 63 61.389 15.050 14.790 1.00 14.74 O

ATOM 343 ND2 ASN A 63 60.490 15.957 12.940 1.00 14.48 N

ATOM 344 C ASN A 63 58.337 11.914 14.692 1.00 11.64 C

ATOM 345 O ASN A 63 57.223 12.448 14.733 1.00 11.66 O

ATOM 346 N ASN A 64 58.536 10.605 14.857 1.00 11.57 N

ATOM 347 CA ASN A 64 57.470 9.643 15.182 1.00 11.68 C

ATOM 348 CB ASN A 64 56.849 9.957 16.552 1.00 11.93 C

ATOM 349 CG ASN A 64 57.879 9.976 17.660 1.00 12.44 C

ATOM 350 ODl ASN A 64 58.637 9.022 17.833 1.00 13.97 O

ATOM 351 ND2 ASN A 64 57.921 11.069 18.412 1.00 13.50 N

ATOM 352 C ASN A 64 56.391 9.485 14.109 1.00 11.36 C

ATOM 353 O ASN A 64 55.259 9.105 14.405 1.00 11.30 O

ATOM 354 N GLU A 65 56.756 9.773 12.865 1.00 10.97 N

ATOM 355 CA GLU A 65 55.843 9.655 11.736 1.00 11.10 C

ATOM 356 CB GLU A 65 55.417 11.036 11.222 1.00 10.86 C

ATOM 357 CG GLU A 65 54.667 11.894 12.252 1.00 11.82 C W2025-7029WO / AM102903-PCT

ATOM 358 CD GLU A 65 53.976 13.105 11.638 1.00 12.48 C

ATOM 359 OEl GLU A 65 52.817 13.380 12.017 1.00 14.44 O

ATOM 360 OE2 GLU A 65 54.583 13.775 10.774 1.00 14.37 O

ATOM 361 C GLU A 65 56.502 8.849 10.622 1.00 10.55 C

ATOM 362 O GLU A 65 57.694 9.012 10.349 1.00 10.16 O

ATOM 363 N ILE A 66 55.719 7.974 9.993 1.00 10.20 N

ATOM 364 CA ILE A 66 56.208 7.125 8.903 1.00 9.69 C

ATOM 365 CB ILE A 66 55.165 6.034 8.527 1.00 9.74 C

ATOM 366 CGl ILE A 66 55.776 4.973 7.595 1.00 9.72 C

ATOM 367 CDl ILE A 66 54.957 3.689 7.496 1.00 9.55 C

ATOM 368 CG2 ILE A 66 53.884 6.661 7.946 1.00 8.49 C

ATOM 369 C ILE A 66 56.622 7.957 7.677 1.00 9.81 C

ATOM 370 O ILE A 66 55.952 8.923 7.312 1.00 9.40 O

ATOM 371 N THR A 67 57.742 7.580 7.063 1.00 10.06 N

ATOM 372 CA THR A 67 58.270 8.287 5.896 1.00 10.01 C

ATOM 373 CB THR A 67 59.463 9.206 6.272 1.00 10.15 C

ATOM 374 OGl THR A 67 60.570 8.397 6.684 1.00 10.18 O

ATOM 375 CG2 THR A 67 59.096 10.178 7.385 1.00 10.69 C

ATOM 376 C THR A 67 58.790 7.317 4.847 1.00 9.87 C

ATOM 377 O THR A 67 58.960 6.126 5.115 1.00 10.21 O

ATOM 378 N THR A 68 59.060 7.847 3.657 1.00 9.61 N

ATOM 379 CA THR A 68 59.811 7.134 2.625 1.00 9.36 C

ATOM 380 CB THR A 68 59.663 7.832 1.263 1.00 9.22 C

ATOM 381 OGl THR A 68 60.143 9.180 1.362 1.00 8.35 O

ATOM 382 CG2 THR A 68 58.208 7.853 0.813 1.00 8.66 C

ATOM 383 C THR A 68 61.300 7.092 2.998 1.00 9.53 C

ATOM 384 O THR A 68 61.724 7.751 3.950 1.00 9.45 O

ATOM 385 N ILE A 69 62.082 6.321 2.242 1.00 9.62 N

ATOM 386 CA ILE A 69 63.529 6.196 2.455 1.00 10.09 C

ATOM 387 CB ILE A 69 63.889 4.805 3.061 1.00 10.23 C

ATOM 388 CGl ILE A 69 63.528 4.770 4.551 1.00 10.44 C

ATOM 389 CDl ILE A 69 63.730 3.418 5.217 1.00 10.78 C

ATOM 390 CG2 ILE A 69 65.366 4.469 2.855 1.00 11.42 C

ATOM 391 C ILE A 69 64.323 6.453 1.165 1.00 9.90 C

ATOM 392 O ILE A 69 65.439 6.978 1.202 1.00 10.05 O

ATOM 393 N GLU A 70 63.749 6.071 0.028 1.00 9.60 N

ATOM 394 CA GLU A 70 64.392 6.296 -1.261 1.00 9.48 C

ATOM 395 CB GLU A 70 64.334 5.041 -2.141 1.00 9.38 C

ATOM 396 CG GLU A 70 65.172 3.878 -1.628 1.00 10.79 C

ATOM 397 CD GLU A 70 66.668 4.128 -1.739 1.00 11.34 C

ATOM 398 OEl GLU A 70 67.424 3.532 -0.952 1.00 11.56 O

ATOM 399 OE2 GLU A 70 67.088 4.918 -2.611 1.00 12.22 O

ATOM 400 C GLU A 70 63.733 7.462 -1.968 1.00 9.09 C

ATOM 401 O GLU A 70 62.528 7.688 -1.819 1.00 8.86 O

ATOM 402 N TRP A 71 64.539 8.189 -2.740 1.00 8.87 N

ATOM 403 CA TRP A 71 64.103 9.373 -3.488 1.00 8.78 C

ATOM 404 CB TRP A 71 65.251 9.889 -4.365 1.00 8.91 C

ATOM 405 CG TRP A 71 65.665 8.902 -5.423 1.00 8.84 C

ATOM 406 CDl TRP A 71 66.435 7.785 -5.250 1.00 9.33 C

ATOM 407 NEl TRP A 71 66.586 7.120 -6.444 1.00 9.02 N

ATOM 408 CE2 TRP A 71 65.905 7.802 -7.419 1.00 9.17 C

ATOM 409 CD2 TRP A 71 65.307 8.931 -6.809 1.00 9.49 C

ATOM 410 CE3 TRP A 71 64.546 9.804 -7.599 1.00 9.50 C

ATOM 411 CZ3 TRP A 71 64.407 9.527 -8.953 1.00 9.42 C

ATOM 412 CH2 TRP A 71 65.015 8.392 -9.534 1.00 9.17 C

ATOM 413 CZ2 TRP A 71 65.768 7.525 -8.787 1.00 9.43 C

ATOM 414 C TRP A 71 62.867 9.113 -4.354 1.00 8.49 C

ATOM 415 O TRP A 71 62.019 9.997 -4.511 1.00 8.57 O

ATOM 416 N ASN A 72 62.771 7.900 -4.901 1.00 7.78 N

ATOM 417 CA ASN A 72 61.701 7.542 -5.833 1.00 7.42 C

ATOM 418 CB ASN A 72 62.288 6.926 -7.114 1.00 7.41 C

ATOM 419 CG ASN A 72 63.082 5.644 -6.857 1.00 7.16 C

ATOM 420 ODl ASN A 72 63.482 5.346 -5.727 1.00 7.69 O W2025-7029WO / AM102903-PCT

ATOM 421 ND2 ASN A 72 63.333 4.895 -7.921 1.00 5.67 N

ATOM 422 C ASN A 72 60.612 6.624 -5.258 1.00 7.09 C

ATOM 423 O ASN A 72 59.821 6.061 -6.017 1.00 6.95 O

ATOM 424 N ASP A 73 60.569 6.488 -3.933 1.00 6.63 N

ATOM 425 CA ASP A 73 59.603 5.595 -3.270 1.00 6.78 C

ATOM 426 CB ASP A 73 59.715 5.680 -1.742 1.00 6.64 C

ATOM 427 CG ASP A 73 60.640 4.621 -1.149 1.00 6.92 C

ATOM 428 ODl ASP A 73 60.925 3.601 -1.819 1.00 7.04 O

ATOM 429 OD2 ASP A 73 61.072 4.814 0.006 1.00 7.02 O

ATOM 430 C ASP A 73 58.146 5.806 -3.686 1.00 6.67 C

ATOM 431 O ASP A 73 57.410 4.834 -3.848 1.00 6.66 O

ATOM 432 N VAL A 74 57.734 7.064 -3.852 1.00 6.81 N

ATOM 433 CA VAL A 74 56.339 7.386 -4.205 1.00 6.73 C

ATOM 434 CB VAL A 74 56.041 8.926 -4.172 1.00 6.63 C

ATOM 435 CGl VAL A 74 54.660 9.219 -4.759 1.00 6.14 C

ATOM 436 CG2 VAL A 74 56.121 9.465 -2.753 1.00 6.76 C

ATOM 437 C VAL A 74 55.974 6.808 -5.569 1.00 6.54 C

ATOM 438 O VAL A 74 54.879 6.258 -5.752 1.00 6.06 O

ATOM 439 N THR A 75 56.900 6.939 -6.517 1.00 6.68 N

ATOM 440 CA THR A 75 56.760 6.352 -7.850 1.00 6.85 C

ATOM 441 CB THR A 75 57.913 6.814 -8.777 1.00 6.68 C

ATOM 442 OGl THR A 75 57.838 8.234 -8.934 1.00 7.10 O

ATOM 443 CG2 THR A 75 57.830 6.155 -10.154 1.00 7.29 C

ATOM 444 C THR A 75 56.689 4.824 -7.789 1.00 7.05 C

ATOM 445 O THR A 75 55.852 4.202 -8.460 1.00 7.02 O

ATOM 446 N LEU A 76 57.564 4.227 -6.980 1.00 7.12 N

ATOM 447 CA LEU A 76 57.580 2.778 -6.796 1.00 7.58 C

ATOM 448 CB LEU A 76 58.852 2.308 -6.068 1.00 7.73 C

ATOM 449 CG LEU A 76 60.222 2.769 -6.596 1.00 8.48 C

ATOM 450 CDl LEU A 76 61.369 2.104 -5.837 1.00 10.21 C

ATOM 451 CD2 LEU A 76 60.364 2.534 -8.091 1.00 8.86 C

ATOM 452 C LEU A 76 56.319 2.282 -6.079 1.00 7.59 C

ATOM 453 O LEU A 76 55.791 1.237 -6.443 1.00 7.65 O

ATOM 454 N TYR A 77 55.836 3.040 -5.089 1.00 7.63 N

ATOM 455 CA TYR A 77 54.570 2.720 -4.398 1.00 7.87 C

ATOM 456 CB TYR A 77 54.176 3.802 -3.391 1.00 7.62 C

ATOM 457 CG TYR A 77 54.993 3.959 -2.122 1.00 7.07 C

ATOM 458 CDl TYR A 77 55.926 3.000 -1.706 1.00 6.85 C

ATOM 459 CEl TYR A 77 56.663 3.185 -0.521 1.00 6.51 C

ATOM 460 CZ TYR A 77 56.438 4.322 0.256 1.00 6.53 C

ATOM 461 OH TYR A 77 57.126 4.536 1.432 1.00 6.77 O

ATOM 462 CE2 TYR A 77 55.511 5.268 -0.138 1.00 6.51 C

ATOM 463 CD2 TYR A 77 54.794 5.080 -1.312 1.00 6.86 C

ATOM 464 C TYR A 77 53.414 2.613 -5.387 1.00 8.06 C

ATOM 465 O TYR A 77 52.593 1.698 -5.301 1.00 7.97 O

ATOM 466 N GLN A 78 53.340 3.582 -6.303 1.00 8.54 N

ATOM 467 CA GLN A 78 52.276 3.643 -7.305 1.00 9.17 C

ATOM 468 CB GLN A 78 52.325 4.981 -8.072 1.00 9.20 C

ATOM 469 CG GLN A 78 51.833 6.168 -7.216 1.00 10.89 C

ATOM 470 CD GLN A 78 52.118 7.560 -7.789 1.00 11.43 C

ATOM 471 OEl GLN A 78 52.679 7.714 -8.878 1.00 15.34 O

ATOM 472 NE2 GLN A 78 51.715 8.588 -7.041 1.00 13.89 N

ATOM 473 C GLN A 78 52.315 2.423 -8.235 1.00 8.68 C

ATOM 474 O GLN A 78 51.279 1.805 -8.497 1.00 8.71 O

ATOM 475 N ALA A 79 53.509 2.060 -8.703 1.00 8.41 N

ATOM 476 CA ALA A 79 53.687 0.860 -9.531 1.00 8.16 C

ATOM 477 CB ALA A 79 55.086 0.826 -10.125 1.00 8.23 C

ATOM 478 C ALA A 79 53.403 -0.426 -8.745 1.00 7.76 C

ATOM 479 O ALA A 79 52.779 -1.353 -9.257 1.00 7.82 O

ATOM 480 N PHE A 80 53.870 -0.460 -7.500 1.00 7.30 N

ATOM 481 CA PHE A 80 53.717 -1.607 -6.611 1.00 6.93 C

ATOM 482 CB PHE A 80 54.446 -1.315 -5.296 1.00 7.16 C

ATOM 483 CG PHE A 80 54.584 -2.500 -4.378 1.00 6.89 C W2025-7029WO / AM102903-PCT

ATOM 484 CDl PHE A 80 53.762 -2.626 -3.260 1.00 6.92 C

ATOM 485 CEl PHE A 80 53.907 -3.712 -2.383 1.00 8.03 C

ATOM 486 CZ PHE A 80 54.892 -4.670 -2.620 1.00 7.01 C

ATOM 487 CE2 PHE A 80 55.723 -4.550 -3.733 1.00 8.28 C

ATOM 488 CD2 PHE A 80 55.573 -3.457 -4.598 1.00 7.88 C

ATOM 489 C PHE A 80 52.241 -1.891 -6.349 1.00 6.86 C

ATOM 490 O PHE A 80 51.769 -3.015 -6.554 1.00 6.62 O

ATOM 491 N ASN A 81 51.510 -0.866 -5.919 1.00 6.56 N

ATOM 492 CA ASN A 81 50.105 -1.040 -5.570 1.00 7.10 C

ATOM 493 CB ASN A 81 49.649 0.040 -4.581 1.00 6.78 C

ATOM 494 CG ASN A 81 50.295 -0.121 -3.211 1.00 7.57 C

ATOM 495 ODl ASN A 81 50.530 -1.242 -2.761 1.00 7.86 O

ATOM 496 ND2 ASN A 81 50.596 0.998 -2.546 1.00 7.22 N

ATOM 497 C ASN A 81 49.210 -1.134 -6.807 1.00 7.34 C

ATOM 498 O ASN A 81 48.097 -1.658 -6.738 1.00 7.60 O

ATOM 499 N GLY A 82 49.732 -0.670 -7.942 1.00 7.77 N

ATOM 500 CA GLY A 82 49.067 -0.806 -9.236 1.00 8.30 C

ATOM 501 C GLY A 82 48.914 -2.246 -9.698 1.00 8.70 C

ATOM 502 O GLY A 82 48.030 -2.552 -10.499 1.00 8.68 O

ATOM 503 N LEU A 83 49.771 -3.129 -9.182 1.00 8.93 N

ATOM 504 CA LEU A 83 49.746 -4.561 -9.514 1.00 9.07 C

ATOM 505 CB LEU A 83 50.907 -5.289 -8.830 1.00 9.07 C

ATOM 506 CG LEU A 83 52.343 -4.915 -9.239 1.00 8.90 C

ATOM 507 CDl LEU A 83 53.334 -5.500 -8.244 1.00 8.79 C

ATOM 508 CD2 LEU A 83 52.675 -5.372 -10.667 1.00 8.95 C

ATOM 509 C LEU A 83 48.424 -5.229 -9.136 1.00 9.42 C

ATOM 510 O LEU A 83 48.035 -6.239 -9.740 1.00 9.65 O

ATOM 511 N LYS A 84 47.750 -4.658 -8.137 1.00 9.13 N

ATOM 512 CA LYS A 84 46.444 -5.128 -7.666 1.00 9.34 C

ATOM 513 CB LYS A 84 46.049 -4.399 -6.384 1.00 9.04 C

ATOM 514 CG LYS A 84 46.947 -4.711 -5.187 1.00 8.14 C

ATOM 515 CD LYS A 84 46.372 -4.154 -3.900 1.00 6.97 C

ATOM 516 CE LYS A 84 46.805 -2.717 -3.643 1.00 5.96 C

ATOM 517 NZ LYS A 84 46.035 -2.168 -2.490 1.00 5.13 N

ATOM 518 C LYS A 84 45.325 -4.986 -8.706 1.00 9.80 C

ATOM 519 O LYS A 84 44.286 -5.641 -8.590 1.00 9.63 O

ATOM 520 N ASN A 85 45.537 -4.132 -9.707 1.00 10.31 N

ATOM 521 CA ASN A 85 44.620 -4.019 -10.839 1.00 11.24 C

ATOM 522 CB ASN A 85 45.026 -2.859 -11.767 1.00 11.67 C

ATOM 523 CG ASN A 85 45.008 -1.498 -11.064 1.00 13.14 C

ATOM 524 ODl ASN A 85 44.067 -1.161 -10.343 1.00 14.66 O

ATOM 525 ND2 ASN A 85 46.050 -0.705 -11.291 1.00 15.55 N

ATOM 526 C ASN A 85 44.538 -5.325 -11.634 1.00 11.38 C

ATOM 527 O ASN A 85 43.518 -5.607 -12.269 1.00 11.50 O

ATOM 528 N LYS A 86 45.606 -6.123 -11.570 1.00 11.48 N

ATOM 529 CA LYS A 86 45.719 -7.368 -12.336 1.00 11.84 C

ATOM 530 CB LYS A 86 47.130 -7.495 -12.917 1.00 12.41 C

ATOM 531 CG LYS A 86 47.430 -6.515 -14.048 1.00 13.80 C

ATOM 532 CD LYS A 86 48.871 -6.650 -14.505 1.00 16.71 C

ATOM 533 CE LYS A 86 49.291 -5.478 -15.376 1.00 18.88 C

ATOM 534 NZ LYS A 86 50.700 -5.638 -15.831 1.00 20.39 N

ATOM 535 C LYS A 86 45.374 -8.630 -11.538 1.00 11.74 C

ATOM 536 O LYS A 86 45.316 -9.734 -12.098 1.00 11.65 O

ATOM 537 N ASN A 87 45.165 -8.461 -10.234 1.00 11.41 N

ATOM 538 CA ASN A 87 44.844 -9.560 -9.326 1.00 10.97 C

ATOM 539 CB ASN A 87 46.136 -10.180 -8.764 1.00 10.82 C

ATOM 540 CG ASN A 87 45.883 -11.351 -7.809 1.00 10.69 C

ATOM 541 ODl ASN A 87 44.739 -11.686 -7.481 1.00 9.70 O

ATOM 542 ND2 ASN A 87 46.966 -11.970 -7.350 1.00 9.04 N

ATOM 543 C ASN A 87 43.937 -9.044 -8.211 1.00 10.65 C

ATOM 544 O ASN A 87 44.389 -8.339 -7.302 1.00 10.96 O

ATOM 545 N SER A 88 42.661 -9.416 -8.276 1.00 10.43 N

ATOM 546 CA SER A 88 41.640 -8.893 -7.359 1.00 10.38 C W2025-7029WO / AM102903-PCT

ATOM 547 CB SER A 88 40.242 -9.124 -7.941 1.00 10.32 C

ATOM 548 OG SER A 88 39.959 -10.506 -8.038 1.00 10.71 O

ATOM 549 C SER A 88 41.695 -9.433 -5.923 1.00 10.38 C

ATOM 550 O SER A 88 40.907 -9.014 -5.064 1.00 10.45 O

ATOM 551 N GLN A 89 42.597 -10.372 -5.663 1.00 10.13 N

ATOM 552 CA GLN A 89 42.757 -10.900 -4.320 1.00 10.33 C

ATOM 553 CB GLN A 89 42.542 -12.417 -4.300 1.00 10.69 C

ATOM 554 CG GLN A 89 41.073 -12.852 -4.445 1.00 13.16 C

ATOM 555 CD GLN A 89 40.205 -12.426 -3.266 1.00 16.62 C

ATOM 556 OEl GLN A 89 40.593 -12.577 -2.104 1.00 18.33 O

ATOM 557 NE2 GLN A 89 39.022 -11.891 -3.564 1.00 17.66 N

ATOM 558 C GLN A 89 44.102 -10.508 -3.691 1.00 9.81 C

ATOM 559 O GLN A 89 44.303 -10.688 -2.493 1.00 10.08 O

ATOM 560 N LEU A 90 44.993 -9.940 -4.500 1.00 9.10 N

ATOM 561 CA LEU A 90 46.304 -9.497 -4.042 1.00 8.45 C

ATOM 562 CB LEU A 90 47.178 -9.105 -5.240 1.00 8.35 C

ATOM 563 CG LEU A 90 48.617 -8.634 -4.974 1.00 8.25 C

ATOM 564 CDl LEU A 90 49.451 -9.724 -4.294 1.00 7.61 C

ATOM 565 CD2 LEU A 90 49.264 -8.193 -6.273 1.00 7.84 C

ATOM 566 C LEU A 90 46.205 -8.338 -3.044 1.00 8.35 C

ATOM 567 O LEU A 90 45.510 -7.348 -3.289 1.00 7.96 O

ATOM 568 N LYS A 91 46.886 -8.487 -1.911 1.00 8.09 N

ATOM 569 CA LYS A 91 46.942 -7.437 -0.905 1.00 8.45 C

ATOM 570 CB LYS A 91 46.314 -7.901 0.412 1.00 8.46 C

ATOM 571 CG LYS A 91 44.805 -8.144 0.321 1.00 9.19 C

ATOM 572 CD LYS A 91 44.222 -8.525 1.673 1.00 10.14 C

ATOM 573 CE LYS A 91 42.744 -8.899 1.560 1.00 12.76 C

ATOM 574 NZ LYS A 91 42.209 -9.407 2.871 1.00 16.10 N

ATOM 575 C LYS A 91 48.385 -6.975 -0.709 1.00 7.78 C

ATOM 576 O LYS A 91 49.321 -7.774 -0.806 1.00 7.85 O

ATOM 577 N THR A 92 48.556 -5.678 -0.465 1.00 6.99 N

ATOM 578 CA THR A 92 49.882 -5.098 -0.290 1.00 6.46 C

ATOM 579 CB THR A 92 50.188 -3.995 -1.328 1.00 6.43 C

ATOM 580 OGl THR A 92 49.260 -2.917 -1.166 1.00 7.21 O

ATOM 581 CG2 THR A 92 50.116 -4.539 -2.759 1.00 5.54 C

ATOM 582 C THR A 92 50.046 -4.520 1.109 1.00 5.97 C

ATOM 583 O THR A 92 49.086 -4.038 1.717 1.00 5.21 O

ATOM 584 N LEU A 93 51.273 -4.601 1.617 1.00 5.38 N

ATOM 585 CA LEU A 93 51.621 -4.016 2.899 1.00 5.12 C

ATOM 586 CB LEU A 93 51.739 -5.085 3.996 1.00 5.51 C

ATOM 587 CG LEU A 93 50.481 -5.887 4.354 1.00 6.35 C

ATOM 588 CDl LEU A 93 50.363 -7.144 3.486 1.00 8.12 C

ATOM 589 CD2 LEU A 93 50.498 -6.260 5.832 1.00 8.11 C

ATOM 590 C LEU A 93 52.928 -3.255 2.767 1.00 4.86 C

ATOM 591 O LEU A 93 53.754 -3.551 1.894 1.00 4.26 O

ATOM 592 N LEU A 94 53.094 -2.263 3.632 1.00 4.70 N

ATOM 593 CA LEU A 94 54.337 -1.528 3.726 1.00 4.78 C

ATOM 594 CB LEU A 94 54.052 -0.023 3.726 1.00 4.54 C

ATOM 595 CG LEU A 94 55.189 0.989 3.851 1.00 4.07 C

ATOM 596 CDl LEU A 94 56.111 0.957 2.640 1.00 2.77 C

ATOM 597 CD2 LEU A 94 54.575 2.376 4.019 1.00 4.35 C

ATOM 598 C LEU A 94 55.071 -1.954 4.997 1.00 5.01 C

ATOM 599 O LEU A 94 54.492 -1.952 6.085 1.00 5.27 O

ATOM 600 N ALA A 95 56.339 -2.327 4.847 1.00 5.17 N

ATOM 601 CA ALA A 95 57.175 -2.711 5.984 1.00 5.39 C

ATOM 602 CB ALA A 95 58.118 -3.842 5.589 1.00 5.12 C

ATOM 603 C ALA A 95 57.968 -1.515 6.511 1.00 5.67 C

ATOM 604 O ALA A 95 58.653 -0.837 5.748 1.00 5.94 O

ATOM 605 N ILE A 96 57.873 -1.257 7.811 1.00 6.18 N

ATOM 606 CA ILE A 96 58.673 -0.200 8.447 1.00 6.69 C

ATOM 607 CB ILE A 96 57.801 0.788 9.289 1.00 6.75 C

ATOM 608 CGl ILE A 96 58.687 1.864 9.947 1.00 6.74 C

ATOM 609 CDl ILE A 96 57.940 2.942 10.689 1.00 6.66 C W2025-7029WO / AM102903-PCT

ATOM 610 CG2 ILE A 96 56.922 0.028 10.309 1.00 6.50 C

ATOM 611 C ILE A 96 59.803 -0.801 9.295 1.00 6.81 C

ATOM 612 O ILE A 96 59.575 -1.726 10.081 1.00 6.93 O

ATOM 613 N GLY A 97 61.016 -0.279 9.113 1.00 7.17 N

ATOM 614 CA GLY A 97 62.172 -0.699 9.901 1.00 7.37 C

ATOM 615 C GLY A 97 63.282 -1.333 9.080 1.00 7.64 C

ATOM 616 O GLY A 97 63.821 -0.722 8.155 1.00 6.93 O

ATOM 617 N GLY A 98 63.621 -2.570 9.429 1.00 7.99 N

ATOM 618 CA GLY A 98 64.737 -3.272 8.811 1.00 8.73 C

ATOM 619 C GLY A 98 65.977 -3.256 9.682 1.00 9.21 C

ATOM 620 O GLY A 98 65.982 -2.680 10.775 1.00 9.45 O

ATOM 621 N TRP A 99 67.035 -3.887 9.185 1.00 9.86 N

ATOM 622 CA TRP A 99 68.294 -4.027 9.917 1.00 10.36 C

ATOM 623 CB TRP A 99 69.235 -4.978 9.173 1.00 10.31 C

ATOM 624 CG TRP A 99 70.314 -5.561 10.031 1.00 10.59 C

ATOM 625 CDl TRP A 99 71.656 -5.289 9.968 1.00 11.06 C

ATOM 626 NEl TRP A 99 72.333 -6.022 10.914 1.00 11.46 N

ATOM 627 CE2 TRP A 99 71.432 -6.786 11.610 1.00 10.92 C

ATOM 628 CD2 TRP A 99 70.148 -6.520 11.081 1.00 10.42 C

ATOM 629 CE3 TRP A 99 69.040 -7.185 11.624 1.00 10.11 C

ATOM 630 CZ3 TRP A 99 69.246 -8.084 12.665 1.00 10.44 C

ATOM 631 CH2 TRP A 99 70.533 -8.324 13.171 1.00 10.11 C

ATOM 632 CZ2 TRP A 99 71.636 -7.691 12.655 1.00 10.76 C

ATOM 633 C TRP A 99 68.990 -2.689 10.175 1.00 10.61 C

ATOM 634 O TRP A 99 69.215 -2.328 11.326 1.00 10.52 O

ATOM 635 N ASN A 100 69.318 -1.957 9.109 1.00 10.98 N

ATOM 636 CA ASN A 100 70.043 -0.675 9.227 1.00 11.34 C

ATOM 637 CB ASN A 100 70.362 -0.089 7.845 1.00 11.97 C

ATOM 638 CG ASN A 100 71.464 -0.845 7.119 1.00 13.76 C

ATOM 639 ODl ASN A 100 72.360 -1.432 7.734 1.00 15.41 O

ATOM 640 ND2 ASN A 100 71.408 -0.819 5.789 1.00 16.52 N

ATOM 641 C ASN A 100 69.331 0.381 10.081 1.00 10.94 C

ATOM 642 O ASN A 100 69.984 1.199 10.732 1.00 10.98 O

ATOM 643 N PHE A 101 67.999 0.347 10.072 1.00 10.34 N

ATOM 644 CA PHE A 101 67.148 1.274 10.833 1.00 9.96 C

ATOM 645 CB PHE A 101 65.675 0.949 10.550 1.00 10.04 C

ATOM 646 CG PHE A 101 64.701 1.956 11.087 1.00 10.35 C

ATOM 647 CDl PHE A 101 64.424 3.127 10.380 1.00 11.12 C

ATOM 648 CEl PHE A 101 63.511 4.062 10.869 1.00 10.73 C

ATOM 649 CZ PHE A 101 62.854 3.822 12.067 1.00 10.31 C

ATOM 650 CE2 PHE A 101 63.116 2.653 12.777 1.00 10.56 C

ATOM 651 CD2 PHE A 101 64.035 1.726 12.284 1.00 10.40 C

ATOM 652 C PHE A 101 67.426 1.237 12.342 1.00 9.77 C

ATOM 653 O PHE A 101 67.336 2.265 13.031 1.00 9.67 O

ATOM 654 N GLY A 102 67.760 0.052 12.845 1.00 9.35 N

ATOM 655 CA GLY A 102 68.080 -0.129 14.254 1.00 9.13 C

ATOM 656 C GLY A 102 66.847 -0.130 15.128 1.00 8.99 C

ATOM 657 O GLY A 102 65.729 -0.353 14.652 1.00 9.07 O

ATOM 658 N THR A 103 67.049 0.139 16.413 1.00 9.13 N

ATOM 659 CA THR A 103 65.970 0.065 17.395 1.00 8.99 C

ATOM 660 CB THR A 103 66.330 -0.888 18.550 1.00 9.36 C

ATOM 661 OGl THR A 103 67.531 -0.434 19.198 1.00 9.10 O

ATOM 662 CG2 THR A 103 66.531 -2.311 18.028 1.00 9.30 C

ATOM 663 C THR A 103 65.571 1.423 17.970 1.00 9.11 C

ATOM 664 O THR A 103 64.411 1.616 18.346 1.00 8.98 O

ATOM 665 N ALA A 104 66.531 2.351 18.028 1.00 9.05 N

ATOM 666 CA ALA A 104 66.345 3.674 18.667 1.00 9.14 C

ATOM 667 CB ALA A 104 67.572 4.567 18.443 1.00 9.07 C

ATOM 668 C ALA A 104 65.051 4.434 18.311 1.00 8.90 C

ATOM 669 O ALA A 104 64.362 4.916 19.217 1.00 8.92 O

ATOM 670 N PRO A 105 64.721 4.559 17.004 1.00 8.64 N

ATOM 671 CA PRO A 105 63.484 5.275 16.685 1.00 8.42 C

ATOM 672 CB PRO A 105 63.493 5.338 15.155 1.00 8.44 C W2025-7029WO / AM102903-PCT

ATOM 673 CG PRO A 105 64.907 5.076 14.762 1.00 8.71 C

ATOM 674 CD PRO A 105 65.411 4.118 15.778 1.00 8.55 C

ATOM 675 C PRO A 105 62.220 4.570 17.182 1.00 8.16 C

ATOM 676 O PRO A 105 61.258 5.244 17.550 1.00 7.98 O

ATOM 677 N PHE A 106 62.227 3.236 17.195 1.00 7.91 N

ATOM 678 CA PHE A 106 61.089 2.461 17.704 1.00 7.76 C

ATOM 679 CB PHE A 106 61.239 0.976 17.373 1.00 7.52 C

ATOM 680 CG PHE A 106 60.940 0.617 15.939 1.00 7.29 C

ATOM 681 CDl PHE A 106 59.667 0.794 15.407 1.00 6.91 C

ATOM 682 CEl PHE A 106 59.383 0.438 14.090 1.00 7.80 C

ATOM 683 CZ PHE A 106 60.383 -0.126 13.290 1.00 7.85 C

ATOM 684 CE2 PHE A 106 61.653 -0.324 13.818 1.00 8.22 C

ATOM 685 CD2 PHE A 106 61.923 0.040 15.142 1.00 6.75 C

ATOM 686 C PHE A 106 60.940 2.629 19.215 1.00 7.61 C

ATOM 687 O PHE A 106 59.838 2.851 19.714 1.00 7.72 O

ATOM 688 N THR A 107 62.060 2.523 19.931 1.00 7.76 N

ATOM 689 CA THR A 107 62.102 2.763 21.375 1.00 7.93 C

ATOM 690 CB THR A 107 63.541 2.633 21.929 1.00 8.14 C

ATOM 691 OGl THR A 107 64.047 1.323 21.642 1.00 7.34 O

ATOM 692 CG2 THR A 107 63.577 2.869 23.443 1.00 7.97 C

ATOM 693 C THR A 107 61.503 4.123 21.759 1.00 8.14 C

ATOM 694 O THR A 107 60.643 4.198 22.646 1.00 8.20 O

ATOM 695 N ALA A 108 61.945 5.183 21.081 1.00 8.07 N

ATOM 696 CA ALA A 108 61.462 6.532 21.360 1.00 8.01 C

ATOM 697 CB ALA A 108 62.291 7.570 20.614 1.00 8.22 C

ATOM 698 C ALA A 108 59.974 6.691 21.037 1.00 8.04 C

ATOM 699 O ALA A 108 59.236 7.316 21.797 1.00 7.81 O

ATOM 700 N MET A 109 59.542 6.104 19.923 1.00 7.97 N

ATOM 701 CA MET A 109 58.147 6.194 19.477 1.00 8.17 C

ATOM 702 CB MET A 109 58.024 5.692 18.030 1.00 8.11 C

ATOM 703 CG MET A 109 56.636 5.831 17.416 1.00 7.62 C

ATOM 704 SD MET A 109 55.603 4.385 17.728 1.00 7.37 S

ATOM 705 CE MET A 109 56.357 3.192 16.614 1.00 6.53 C

ATOM 706 C MET A 109 57.152 5.480 20.407 1.00 8.41 C

ATOM 707 O MET A 109 56.043 5.977 20.636 1.00 8.31 O

ATOM 708 N VAL A 110 57.545 4.328 20.953 1.00 8.65 N

ATOM 709 CA VAL A 110 56.636 3.568 21.821 1.00 8.81 C

ATOM 710 CB VAL A 110 56.858 2.025 21.744 1.00 8.79 C

ATOM 711 CGl VAL A 110 56.739 1.530 20.293 1.00 8.46 C

ATOM 712 CG2 VAL A 110 58.197 1.614 22.380 1.00 7.59 C

ATOM 713 C VAL A 110 56.661 4.029 23.277 1.00 9.33 C

ATOM 714 O VAL A 110 55.825 3.602 24.074 1.00 9.43 O

ATOM 715 N SER A 111 57.608 4.911 23.606 1.00 9.93 N

ATOM 716 CA SER A 111 57.863 5.323 24.993 1.00 10.34 C

ATOM 717 CB SER A 111 59.171 6.126 25.089 1.00 10.23 C

ATOM 718 OG SER A 111 59.078 7.371 24.408 1.00 10.14 O

ATOM 719 C SER A 111 56.708 6.086 25.658 1.00 10.78 C

ATOM 720 O SER A 111 56.571 6.059 26.883 1.00 10.97 O

ATOM 721 N THR A 112 55.898 6.780 24.860 1.00 11.25 N

ATOM 722 CA THR A 112 54.740 7.509 25.385 1.00 11.71 C

ATOM 723 CB THR A 112 55.004 9.052 25.507 1.00 11.91 C

ATOM 724 OGl THR A 112 54.995 9.671 24.212 1.00 12.43 O

ATOM 725 CG2 THR A 112 56.345 9.341 26.195 1.00 11.69 C

ATOM 726 C THR A 112 53.500 7.226 24.526 1.00 11.85 C

ATOM 727 O THR A 112 53.630 6.962 23.328 1.00 11.64 O

ATOM 728 N PRO A 113 52.296 7.251 25.138 1.00 11.89 N

ATOM 729 CA PRO A 113 51.075 7.075 24.343 1.00 11.99 C

ATOM 730 CB PRO A 113 49.947 7.147 25.385 1.00 11.83 C

ATOM 731 CG PRO A 113 50.599 6.900 26.694 1.00 12.37 C

ATOM 732 CD PRO A 113 51.997 7.419 26.573 1.00 11.88 C

ATOM 733 C PRO A 113 50.888 8.172 23.294 1.00 12.13 C

ATOM 734 O PRO A 113 50.317 7.915 22.234 1.00 12.01 O

ATOM 735 N GLU A 114 51.364 9.379 23.593 1.00 12.34 N W2025-7029WO / AM102903-PCT

ATOM 736 CA GLU A 114 51.239 10.516 22.670 1.00 12.75 C

ATOM 737 CB GLU A 114 51.629 11.833 23.351 1.00 13.02 C

ATOM 738 CG GLU A 114 50.920 12.108 24.673 1.00 14.96 C

ATOM 739 CD GLU A 114 51.570 11.388 25.854 1.00 18.00 C

ATOM 740 OEl GLU A 114 52.795 11.546 26.058 1.00 19.85 O

ATOM 741 OE2 GLU A 114 50.851 10.670 26.582 1.00 20.09 O

ATOM 742 C GLU A 114 52.052 10.309 21.389 1.00 12.35 C

ATOM 743 O GLU A 114 51.563 10.597 20.295 1.00 12.37 O

ATOM 744 N ASN A 115 53.278 9.802 21.530 1.00 12.08 N

ATOM 745 CA ASN A 115 54.126 9.451 20.380 1.00 11.90 C

ATOM 746 CB ASN A 115 55.551 9.084 20.821 1.00 11.82 C

ATOM 747 CG ASN A 115 56.308 10.251 21.421 1.00 12.62 C

ATOM 748 ODl ASN A 115 55.803 11.372 21.483 1.00 12.73 O

ATOM 749 ND2 ASN A 115 57.535 9.990 21.869 1.00 12.50 N

ATOM 750 C ASN A 115 53.540 8.300 19.571 1.00 11.55 C

ATOM 751 O ASN A 115 53.612 8.307 18.345 1.00 11.50 O

ATOM 752 N ARG A 116 52.965 7.315 20.266 1.00 11.30 N

ATOM 753 CA ARG A 116 52.311 6.190 19.603 1.00 11.03 C

ATOM 754 CB ARG A 116 51.909 5.090 20.597 1.00 10.91 C

ATOM 755 CG ARG A 116 53.106 4.414 21.278 1.00 10.84 C

ATOM 756 CD ARG A 116 52.726 3.148 22.027 1.00 10.29 C

ATOM 757 NE ARG A 116 51.633 3.351 22.978 1.00 8.11 N

ATOM 758 CZ ARG A 116 51.785 3.543 24.286 1.00 7.84 C

ATOM 759 NHl ARG A 116 52.997 3.568 24.830 1.00 7.49 N

ATOM 760 NH2 ARG A 116 50.714 3.713 25.050 1.00 7.30 N

ATOM 761 C ARG A 116 51.114 6.643 18.763 1.00 11.20 C

ATOM 762 O ARG A 116 50.974 6.205 17.621 1.00 10.81 O

ATOM 763 N GLN A 117 50.269 7.521 19.317 1.00 11.38 N

ATOM 764 CA GLN A 117 49.111 8.042 18.571 1.00 11.83 C

ATOM 765 CB GLN A 117 48.176 8.892 19.449 1.00 12.27 C

ATOM 766 CG GLN A 117 47.128 9.673 18.626 1.00 15.14 C

ATOM 767 CD GLN A 117 45.860 10.026 19.388 1.00 19.72 C

ATOM 768 OEl GLN A 117 45.902 10.672 20.445 1.00 21.13 O

ATOM 769 NE2 GLN A 117 44.713 9.621 18.837 1.00 20.42 N

ATOM 770 C GLN A 117 49.548 8.824 17.333 1.00 11.10 C

ATOM 771 O GLN A 117 48.962 8.677 16.264 1.00 11.15 O

ATOM 772 N THR A 118 50.579 9.645 17.490 1.00 10.93 N

ATOM 773 CA THR A 118 51.136 10.419 16.378 1.00 10.81 C

ATOM 774 CB THR A 118 52.277 11.346 16.856 1.00 10.76 C

ATOM 775 OGl THR A 118 51.737 12.341 17.733 1.00 11.85 O

ATOM 776 CG2 THR A 118 52.957 12.036 15.677 1.00 10.56 C

ATOM 111 C THR A 118 51.603 9.494 15.243 1.00 10.30 C

ATOM 778 O THR A 118 51.275 9.722 14.076 1.00 9.99 O

ATOM 779 N PHE A 119 52.350 8.449 15.603 1.00 9.70 N

ATOM 780 CA PHE A 119 52.796 7.436 14.639 1.00 9.17 C

ATOM 781 CB PHE A 119 53.685 6.391 15.324 1.00 8.85 C

ATOM 782 CG PHE A 119 54.168 5.308 14.397 1.00 9.03 C

ATOM 783 CDl PHE A 119 55.149 5.579 13.442 1.00 8.24 C

ATOM 784 CEl PHE A 119 55.580 4.588 12.575 1.00 8.33 C

ATOM 785 CZ PHE A 119 55.037 3.305 12.662 1.00 7.84 C

ATOM 786 CE2 PHE A 119 54.060 3.025 13.607 1.00 6.98 C

ATOM 787 CD2 PHE A 119 53.630 4.023 14.464 1.00 7.77 C

ATOM 788 C PHE A 119 51.627 6.747 13.944 1.00 8.90 C

ATOM 789 O PHE A 119 51.566 6.690 12.714 1.00 8.57 O

ATOM 790 N ILE A 120 50.707 6.224 14.751 1.00 8.85 N

ATOM 791 CA ILE A 120 49.531 5.518 14.259 1.00 8.44 C

ATOM 792 CB ILE A 120 48.659 5.009 15.432 1.00 8.55 C

ATOM 793 CGl ILE A 120 49.375 3.865 16.169 1.00 8.80 C

ATOM 794 CDl ILE A 120 48.842 3.570 17.567 1.00 8.43 C

ATOM 795 CG2 ILE A 120 47.295 4.555 14.923 1.00 8.13 C

ATOM 796 C ILE A 120 48.709 6.381 13.288 1.00 8.36 C

ATOM 797 O ILE A 120 48.352 5.926 12.201 1.00 8.35 O

ATOM 798 N THR A 121 48.433 7.624 13.677 1.00 8.40 N W2025-7029WO / AM102903-PCT

ATOM 799 CA THR A 121 47.735 8.576 12.805 1.00 8.31 C

ATOM 800 CB THR A 121 47.506 9.936 13.516 1.00 8.62 C

ATOM 801 OGl THR A 121 46.715 9.726 14.694 1.00 9.01 O

ATOM 802 CG2 THR A 121 46.784 10.936 12.610 1.00 9.39 C

ATOM 803 C THR A 121 48.480 8.746 11.478 1.00 7.94 C

ATOM 804 O THR A 121 47.866 8.663 10.408 1.00 7.49 O

ATOM 805 N SER A 122 49.798 8.951 11.548 1.00 7.69 N

ATOM 806 CA SER A 122 50.619 9.090 10.335 1.00 7.65 C

ATOM 807 CB SER A 122 52.079 9.427 10.667 1.00 7.57 C

ATOM 808 OG SER A 122 52.819 8.280 11.060 1.00 7.31 O

ATOM 809 C SER A 122 50.546 7.855 9.437 1.00 7.74 C

ATOM 810 O SER A 122 50.447 7.988 8.213 1.00 8.21 O

ATOM 811 N VAL A 123 50.581 6.665 10.046 1.00 7.45 N

ATOM 812 CA VAL A 123 50.488 5.395 9.302 1.00 7.21 C

ATOM 813 CB VAL A 123 50.804 4.162 10.197 1.00 7.23 C

ATOM 814 CGl VAL A 123 50.512 2.853 9.467 1.00 7.33 C

ATOM 815 CG2 VAL A 123 52.261 4.187 10.641 1.00 7.09 C

ATOM 816 C VAL A 123 49.147 5.235 8.560 1.00 6.97 C

ATOM 817 O VAL A 123 49.138 4.935 7.365 1.00 6.37 O

ATOM 818 N ILE A 124 48.025 5.445 9.253 1.00 6.96 N

ATOM 819 CA ILE A 124 46.711 5.372 8.592 1.00 7.10 C

ATOM 820 CB ILE A 124 45.541 5.713 9.555 1.00 7.32 C

ATOM 821 CGl ILE A 124 45.443 4.684 10.688 1.00 7.11 C

ATOM 822 CDl ILE A 124 44.400 5.011 11.764 1.00 6.94 C

ATOM 823 CG2 ILE A 124 44.220 5.823 8.782 1.00 6.88 C

ATOM 824 C ILE A 124 46.674 6.298 7.365 1.00 7.24 C

ATOM 825 O ILE A 124 46.285 5.878 6.269 1.00 6.84 O

ATOM 826 N LYS A 125 47.118 7.542 7.548 1.00 7.78 N

ATOM 827 CA LYS A 125 47.126 8.530 6.465 1.00 8.82 C

ATOM 828 CB LYS A 125 47.538 9.913 6.984 1.00 8.94 C

ATOM 829 CG LYS A 125 47.365 11.037 5.952 1.00 10.30 C

ATOM 830 CD LYS A 125 47.472 12.417 6.591 1.00 11.09 C

ATOM 831 CE LYS A 125 48.920 12.883 6.704 1.00 16.22 C

ATOM 832 NZ LYS A 125 49.432 13.481 5.418 1.00 18.78 N

ATOM 833 C LYS A 125 48.023 8.114 5.298 1.00 8.15 C

ATOM 834 O LYS A 125 47.629 8.231 4.139 1.00 7.64 O

ATOM 835 N PHE A 126 49.221 7.634 5.626 1.00 7.98 N

ATOM 836 CA PHE A 126 50.229 7.212 4.650 1.00 7.68 C

ATOM 837 CB PHE A 126 51.500 6.817 5.403 1.00 7.61 C

ATOM 838 CG PHE A 126 52.771 6.917 4.592 1.00 8.70 C

ATOM 839 CDl PHE A 126 53.303 5.794 3.961 1.00 8.99 C

ATOM 840 CEl PHE A 126 54.496 5.879 3.233 1.00 8.63 C

ATOM 841 CZ PHE A 126 55.172 7.092 3.153 1.00 8.29 C

ATOM 842 CE2 PHE A 126 54.655 8.218 3.791 1.00 8.89 C

ATOM 843 CD2 PHE A 126 53.464 8.125 4.507 1.00 8.54 C

ATOM 844 C PHE A 126 49.739 6.031 3.806 1.00 7.40 C

ATOM 845 O PHE A 126 49.804 6.068 2.572 1.00 7.21 O

ATOM 846 N LEU A 127 49.240 4.990 4.474 1.00 7.30 N

ATOM 847 CA LEU A 127 48.772 3.785 3.772 1.00 6.92 C

ATOM 848 CB LEU A 127 48.451 2.651 4.755 1.00 6.73 C

ATOM 849 CG LEU A 127 49.559 2.177 5.712 1.00 6.15 C

ATOM 850 CDl LEU A 127 49.015 1.121 6.666 1.00 5.92 C

ATOM 851 CD2 LEU A 127 50.808 1.665 4.992 1.00 5.47 C

ATOM 852 C LEU A 127 47.575 4.078 2.860 1.00 7.02 C

ATOM 853 O LEU A 127 47.499 3.550 1.748 1.00 6.65 O

ATOM 854 N ARG A 128 46.662 4.930 3.324 1.00 6.95 N

ATOM 855 CA ARG A 128 45.498 5.309 2.522 1.00 7.46 C

ATOM 856 CB ARG A 128 44.403 5.966 3.380 1.00 7.56 C

ATOM 857 CG ARG A 128 43.711 5.052 4.412 1.00 7.05 C

ATOM 858 CD ARG A 128 43.060 3.814 3.777 1.00 7.11 C

ATOM 859 NE ARG A 128 42.189 3.108 4.723 1.00 6.26 N

ATOM 860 CZ ARG A 128 41.648 1.910 4.514 1.00 6.01 C

ATOM 861 NHl ARG A 128 41.901 1.241 3.390 1.00 5.72 N W2025-7029WO / AM102903-PCT

ATOM 862 NH2 ARG A 128 40.854 1.374 5.437 1.00 4.96 N

ATOM 863 C ARG A 128 45.868 6.209 1.335 1.00 7.79 C

ATOM 864 O ARG A 128 45.276 6.086 0.261 1.00 7.84 O

ATOM 865 N GLN A 129 46.836 7.107 1.526 1.00 8.12 N

ATOM 866 CA GLN A 129 47.293 7.998 0.441 1.00 8.80 C

ATOM 867 CB GLN A 129 48.289 9.059 0.950 1.00 8.81 C

ATOM 868 CG GLN A 129 48.715 10.081 -0.133 1.00 9.53 C

ATOM 869 CD GLN A 129 49.781 11.083 0.317 1.00 9.89 C

ATOM 870 OEl GLN A 129 50.001 11.301 1.515 1.00 10.98 O

ATOM 871 NE2 GLN A 129 50.445 11.705 -0.657 1.00 9.91 N

ATOM 872 C GLN A 129 47.901 7.218 -0.727 1.00 8.35 C

ATOM 873 O GLN A 129 47.600 7.502 -1.889 1.00 8.50 O

ATOM 874 N TYR A 130 48.741 6.231 -0.410 1.00 8.05 N

ATOM 875 CA TYR A 130 49.494 5.491 -1.423 1.00 7.97 C

ATOM 876 CB TYR A 130 50.955 5.321 -0.990 1.00 7.87 C

ATOM 877 CG TYR A 130 51.645 6.642 -0.747 1.00 7.69 C

ATOM 878 CDl TYR A 130 51.816 7.564 -1.787 1.00 6.83 C

ATOM 879 CEl TYR A 130 52.437 8.784 -1.571 1.00 7.60 C

ATOM 880 CZ TYR A 130 52.909 9.091 -0.306 1.00 7.66 C

ATOM 881 OH TYR A 130 53.528 10.297 -0.084 1.00 8.34 O

ATOM 882 CE2 TYR A 130 52.758 8.192 0.744 1.00 7.28 C

ATOM 883 CD2 TYR A 130 52.132 6.973 0.517 1.00 7.67 C

ATOM 884 C TYR A 130 48.868 4.149 -1.809 1.00 7.90 C

ATOM 885 O TYR A 130 49.390 3.443 -2.669 1.00 7.69 O

ATOM 886 N GLU A 131 47.743 3.821 -1.176 1.00 8.22 N

ATOM 887 CA GLU A 131 46.929 2.637 -1.509 1.00 8.86 C

ATOM 888 CB GLU A 131 46.522 2.637 -2.997 1.00 8.79 C

ATOM 889 CG GLU A 131 45.659 3.819 -3.418 1.00 10.28 C

ATOM 890 CD GLU A 131 45.367 3.842 -4.914 1.00 11.28 C

ATOM 891 OEl GLU A 131 45.565 4.910 -5.536 1.00 15.59 O

ATOM 892 OE2 GLU A 131 44.940 2.804 -5.475 1.00 14.65 O

ATOM 893 C GLU A 131 47.537 1.283 -1.084 1.00 7.95 C

ATOM 894 O GLU A 131 47.478 0.305 -1.831 1.00 7.82 O

ATOM 895 N PHE A 132 48.113 1.241 0.118 1.00 7.42 N

ATOM 896 CA PHE A 132 48.543 -0.017 0.746 1.00 6.94 C

ATOM 897 CB PHE A 132 49.743 0.214 1.665 1.00 7.02 C

ATOM 898 CG PHE A 132 51.053 0.378 0.944 1.00 7.20 C

ATOM 899 CDl PHE A 132 51.756 -0.735 0.480 1.00 7.35 C

ATOM 900 CEl PHE A 132 52.979 -0.585 -0.176 1.00 6.89 C

ATOM 901 CZ PHE A 132 53.508 0.684 -0.370 1.00 7.31 C

ATOM 902 CE2 PHE A 132 52.821 1.797 0.095 1.00 7.86 C

ATOM 903 CD2 PHE A 132 51.597 1.637 0.753 1.00 7.03 C

ATOM 904 C PHE A 132 47.395 -0.585 1.586 1.00 6.68 C

ATOM 905 O PHE A 132 46.579 0.175 2.113 1.00 6.57 O

ATOM 906 N ASP A 133 47.353 -1.909 1.731 1.00 5.93 N

ATOM 907 CA ASP A 133 46.316 -2.579 2.528 1.00 5.95 C

ATOM 908 CB ASP A 133 45.937 -3.905 1.877 1.00 5.84 C

ATOM 909 CG ASP A 133 45.382 -3.716 0.504 1.00 6.45 C

ATOM 910 ODl ASP A 133 44.281 -3.142 0.397 1.00 8.24 O

ATOM 911 OD2 ASP A 133 46.059 -4.121 -0.464 1.00 7.15 O

ATOM 912 C ASP A 133 46.679 -2.826 3.988 1.00 5.52 C

ATOM 913 O ASP A 133 45.850 -3.319 4.763 1.00 5.69 O

ATOM 914 N GLY A 134 47.910 -2.497 4.364 1.00 5.44 N

ATOM 915 CA GLY A 134 48.355 -2.706 5.735 1.00 4.98 C

ATOM 916 C GLY A 134 49.799 -2.356 6.026 1.00 4.93 C

ATOM 917 O GLY A 134 50.535 -1.880 5.153 1.00 4.84 O

ATOM 918 N LEU A 135 50.195 -2.592 7.272 1.00 4.77 N

ATOM 919 CA LEU A 135 51.549 -2.313 7.724 1.00 4.87 C

ATOM 920 CB LEU A 135 51.555 -1.165 8.751 1.00 4.44 C

ATOM 921 CG LEU A 135 52.922 -0.693 9.268 1.00 4.99 C

ATOM 922 CDl LEU A 135 53.555 0.315 8.312 1.00 5.14 C

ATOM 923 CD2 LEU A 135 52.828 -0.107 10.677 1.00 4.91 C

ATOM 924 C LEU A 135 52.186 -3.567 8.330 1.00 4.81 C W2025-7029WO / AM102903-PCT

ATOM 925 O LEU A 135 51.561 -4.271 9.133 1.00 4.95 O

ATOM 926 N ASP A 136 53.431 -3.823 7.933 1.00 4.61 N

ATOM 927 CA ASP A 136 54.251 -4.889 8.507 1.00 4.68 C

ATOM 928 CB ASP A 136 54.884 -5.722 7.386 1.00 4.42 C

ATOM 929 CG ASP A 136 55.660 -6.942 7.894 1.00 4.19 C

ATOM 930 ODl ASP A 136 55.095 -7.779 8.620 1.00 2.49 O

ATOM 931 OD2 ASP A 136 56.841 -7.083 7.519 1.00 3.97 O

ATOM 932 C ASP A 136 55.325 -4.249 9.387 1.00 4.80 C

ATOM 933 O ASP A 136 56.109 -3.418 8.922 1.00 4.69 O

ATOM 934 N PHE A 137 55.339 -4.614 10.665 1.00 5.01 N

ATOM 935 CA PHE A 137 56.369 -4.143 11.584 1.00 5.27 C

ATOM 936 CB PHE A 137 55.894 -4.257 13.031 1.00 5.00 C

ATOM 937 CG PHE A 137 55.009 -3.132 13.475 1.00 5.46 C

ATOM 938 CDl PHE A 137 53.659 -3.357 13.730 1.00 5.42 C

ATOM 939 CEl PHE A 137 52.829 -2.318 14.148 1.00 5.49 C

ATOM 940 CZ PHE A 137 53.360 -1.039 14.324 1.00 5.57 C

ATOM 941 CE2 PHE A 137 54.715 -0.806 14.073 1.00 6.31 C

ATOM 942 CD2 PHE A 137 55.527 -1.848 13.656 1.00 5.22 C

ATOM 943 C PHE A 137 57.640 -4.965 11.409 1.00 5.55 C

ATOM 944 O PHE A 137 57.608 -6.191 11.516 1.00 5.69 O

ATOM 945 N ASP A 138 58.756 -4.293 11.139 1.00 6.01 N

ATOM 946 CA ASP A 138 60.055 -4.969 11.053 1.00 6.46 C

ATOM 947 CB ASP A 138 60.607 -4.948 9.621 1.00 6.87 C

ATOM 948 CG ASP A 138 59.776 -5.782 8.657 1.00 8.50 C

ATOM 949 ODl ASP A 138 60.329 -6.735 8.062 1.00 10.39 O

ATOM 950 OD2 ASP A 138 58.574 -5.481 8.485 1.00 9.93 O

ATOM 951 C ASP A 138 61.057 -4.375 12.049 1.00 6.40 C

ATOM 952 O ASP A 138 62.149 -3.937 11.684 1.00 6.19 O

ATOM 953 N TRP A 139 60.660 -4.376 13.317 1.00 6.49 N

ATOM 954 CA TRP A 139 61.513 -3.939 14.407 1.00 6.53 C

ATOM 955 CB TRP A 139 60.644 -3.544 15.601 1.00 6.33 C

ATOM 956 CG TRP A 139 61.364 -3.016 16.818 1.00 6.01 C

ATOM 957 CDl TRP A 139 62.706 -3.063 17.083 1.00 5.72 C

ATOM 958 NEl TRP A 139 62.965 -2.490 18.308 1.00 6.38 N

ATOM 959 CE2 TRP A 139 61.782 -2.069 18.861 1.00 5.57 C

ATOM 960 CD2 TRP A 139 60.752 -2.384 17.948 1.00 5.73 C

ATOM 961 CE3 TRP A 139 59.427 -2.056 18.278 1.00 6.04 C

ATOM 962 CZ3 TRP A 139 59.179 -1.421 19.498 1.00 5.95 C

ATOM 963 CH2 TRP A 139 60.231 -1.111 20.380 1.00 6.22 C

ATOM 964 CZ2 TRP A 139 61.534 -1.430 20.082 1.00 5.96 C

ATOM 965 C TRP A 139 62.416 -5.116 14.769 1.00 6.81 C

ATOM 966 O TRP A 139 61.943 -6.160 15.217 1.00 6.78 O

ATOM 967 N GLU A 140 63.715 -4.946 14.559 1.00 7.28 N

ATOM 968 CA GLU A 140 64.663 -6.014 14.844 1.00 7.87 C

ATOM 969 CB GLU A 140 65.427 -6.415 13.568 1.00 7.91 C

ATOM 970 CG GLU A 140 64.551 -6.686 12.339 1.00 8.48 C

ATOM 971 CD GLU A 140 65.332 -7.266 11.169 1.00 9.13 C

ATOM 972 OEl GLU A 140 65.856 -8.394 11.298 1.00 12.01 O

ATOM 973 OE2 GLU A 140 65.413 -6.608 10.112 1.00 10.49 O

ATOM 974 C GLU A 140 65.645 -5.608 15.949 1.00 7.64 C

ATOM 975 O GLU A 140 66.711 -5.082 15.644 1.00 8.04 O

ATOM 976 N TYR A 141 65.323 -5.840 17.224 1.00 7.35 N

ATOM 977 CA TYR A 141 64.069 -6.418 17.711 1.00 7.36 C

ATOM 978 CB TYR A 141 64.233 -7.910 18.055 1.00 7.36 C

ATOM 979 CG TYR A 141 64.909 -8.722 16.984 1.00 8.47 C

ATOM 980 CDl TYR A 141 66.294 -8.886 16.986 1.00 8.73 C

ATOM 981 CEl TYR A 141 66.926 -9.610 15.996 1.00 9.28 C

ATOM 982 CZ TYR A 141 66.178 -10.183 14.984 1.00 8.84 C

ATOM 983 OH TYR A 141 66.816 -10.900 14.012 1.00 9.64 O

ATOM 984 CE2 TYR A 141 64.802 -10.035 14.948 1.00 9.35 C

ATOM 985 CD2 TYR A 141 64.173 -9.306 15.951 1.00 8.38 C

ATOM 986 C TYR A 141 63.717 -5.669 18.989 1.00 7.06 C

ATOM 987 O TYR A 141 64.590 -5.036 19.589 1.00 6.54 O W2025-7029WO / AM102903-PCT

ATOM 988 N PRO A 142 62.449 -5.747 19.433 1.00 7.08 N

ATOM 989 CA PRO A 142 62.190 -5.250 20.780 1.00 7.15 C

ATOM 990 CB PRO A 142 60.680 -5.459 20.950 1.00 7.21 C

ATOM 991 CG PRO A 142 60.149 -5.571 19.566 1.00 6.82 C

ATOM 992 CD PRO A 142 61.223 -6.256 18.794 1.00 6.97 C

ATOM 993 C PRO A 142 62.964 -6.097 21.793 1.00 7.25 C

ATOM 994 O PRO A 142 63.034 -7.318 21.646 1.00 7.16 O

ATOM 995 N GLY A 143 63.568 -5.449 22.786 1.00 7.57 N

ATOM 996 CA GLY A 143 64.277 -6.159 23.848 1.00 8.32 C

ATOM 997 C GLY A 143 65.690 -6.613 23.520 1.00 9.00 C

ATOM 998 O GLY A 143 66.385 -7.148 24.383 1.00 8.91 O

ATOM 999 N SER A 144 66.124 -6.416 22.277 1.00 9.64 N

ATOM 1000 CA SER A 144 67.492 -6.793 21.894 1.00 10.44 C

ATOM 1001 CB SER A 144 67.570 -8.258 21.421 1.00 10.52 C

ATOM 1002 OG SER A 144 66.787 -8.490 20.266 1.00 11.06 O

ATOM 1003 C SER A 144 68.083 -5.844 20.865 1.00 10.76 C

ATOM 1004 O SER A 144 67.394 -4.951 20.364 1.00 10.66 O

ATOM 1005 N ARG A 145 69.374 -6.029 20.584 1.00 11.10 N

ATOM 1006 CA ARG A 145 70.091 -5.239 19.585 1.00 11.32 C

ATOM 1007 CB ARG A 145 69.552 -5.564 18.184 1.00 11.45 C

ATOM 1008 CG ARG A 145 70.587 -5.592 17.080 1.00 11.46 C

ATOM 1009 CD ARG A 145 69.887 -5.607 15.744 1.00 11.66 C

ATOM 1010 NE ARG A 145 70.653 -4.877 14.746 1.00 13.75 N

ATOM 1011 CZ ARG A 145 70.128 -4.161 13.759 1.00 12.45 C

ATOM 1012 NHl ARG A 145 70.934 -3.543 12.919 1.00 12.96 N

ATOM 1013 NH2 ARG A 145 68.810 -4.051 13.616 1.00 13.08 N

ATOM 1014 C ARG A 145 70.034 -3.729 19.888 1.00 11.54 C

ATOM 1015 O ARG A 145 69.940 -2.898 18.979 1.00 11.81 O

ATOM 1016 N GLY A 146 70.089 -3.383 21.174 1.00 11.46 N

ATOM 1017 CA GLY A 146 70.060 -1.984 21.612 1.00 11.38 C

ATOM 1018 C GLY A 146 68.779 -1.566 22.323 1.00 11.41 C

ATOM 1019 O GLY A 146 68.783 -0.624 23.125 1.00 11.74 O

ATOM 1020 N SER A 147 67.688 -2.271 22.037 1.00 10.92 N

ATOM 1021 CA SER A 147 66.367 -1.957 22.591 1.00 10.45 C

ATOM 1022 CB SER A 147 65.288 -2.603 21.708 1.00 10.29 C

ATOM 1023 OG SER A 147 64.024 -2.661 22.345 1.00 9.45 O

ATOM 1024 C SER A 147 66.239 -2.409 24.053 1.00 10.60 C

ATOM 1025 O SER A 147 66.505 -3.564 24.355 1.00 10.86 O

ATOM 1026 N PRO A 148 65.846 -1.495 24.969 1.00 10.50 N

ATOM 1027 CA PRO A 148 65.712 -1.837 26.399 1.00 10.55 C

ATOM 1028 CB PRO A 148 65.495 -0.469 27.067 1.00 10.38 C

ATOM 1029 CG PRO A 148 64.906 0.380 26.019 1.00 10.48 C

ATOM 1030 CD PRO A 148 65.533 -0.076 24.721 1.00 10.47 C

ATOM 1031 C PRO A 148 64.558 -2.811 26.725 1.00 10.56 C

ATOM 1032 O PRO A 148 63.664 -3.000 25.895 1.00 10.51 O

ATOM 1033 N PRO A 149 64.590 -3.435 27.927 1.00 10.57 N

ATOM 1034 CA PRO A 149 63.647 -4.488 28.352 1.00 10.43 C

ATOM 1035 CB PRO A 149 64.055 -4.755 29.806 1.00 10.39 C

ATOM 1036 CG PRO A 149 65.475 -4.357 29.874 1.00 11.12 C

ATOM 1037 CD PRO A 149 65.590 -3.163 28.978 1.00 10.68 C

ATOM 1038 C PRO A 149 62.156 -4.123 28.294 1.00 9.96 C

ATOM 1039 O PRO A 149 61.317 -5.001 28.060 1.00 9.96 O

ATOM 1040 N GLN A 150 61.835 -2.851 28.513 1.00 9.70 N

ATOM 1041 CA GLN A 150 60.440 -2.392 28.531 1.00 9.38 C

ATOM 1042 CB GLN A 150 60.325 -0.980 29.129 1.00 9.51 C

ATOM 1043 CG GLN A 150 61.014 0.127 28.329 1.00 9.75 C

ATOM 1044 CD GLN A 150 62.448 0.380 28.762 1.00 11.11 C

ATOM 1045 OEl GLN A 150 63.157 -0.533 29.192 1.00 11.07 O

ATOM 1046 NE2 GLN A 150 62.886 1.630 28.642 1.00 10.29 N

ATOM 1047 C GLN A 150 59.770 -2.443 27.156 1.00 9.02 C

ATOM 1048 O GLN A 150 58.540 -2.423 27.062 1.00 8.80 O

ATOM 1049 N ASP A 151 60.580 -2.509 26.100 1.00 8.46 N

ATOM 1050 CA ASP A 151 60.068 -2.531 24.729 1.00 8.40 C W2025-7029WO / AM102903-PCT

ATOM 1051 CB ASP A 151 61.197 -2.276 23.726 1.00 8.22 C

ATOM 1052 CG ASP A 151 61.622 -0.824 23.686 1.00 8.32 C

ATOM 1053 ODl ASP A 151 60.906 0.026 24.257 1.00 10.34 O

ATOM 1054 OD2 ASP A 151 62.666 -0.520 23.080 1.00 8.57 O

ATOM 1055 C ASP A 151 59.303 -3.805 24.367 1.00 8.26 C

ATOM 1056 O ASP A 151 58.436 -3.774 23.490 1.00 8.31 O

ATOM 1057 N LYS A 152 59.634 -4.914 25.035 1.00 8.11 N

ATOM 1058 CA LYS A 152 58.903 -6.175 24.888 1.00 8.22 C

ATOM 1059 CB LYS A 152 59.454 -7.232 25.862 1.00 8.23 C

ATOM 1060 CG LYS A 152 58.693 -8.561 25.892 1.00 8.88 C

ATOM 1061 CD LYS A 152 59.432 -9.587 26.741 1.00 8.84 C

ATOM 1062 CE LYS A 152 58.556 -10.775 27.071 1.00 10.31 C

ATOM 1063 NZ LYS A 152 59.315 -11.845 27.787 1.00 10.02 N

ATOM 1064 C LYS A 152 57.402 -5.962 25.103 1.00 8.06 C

ATOM 1065 O LYS A 152 56.587 -6.298 24.235 1.00 8.08 O

ATOM 1066 N HIS A 153 57.045 -5.384 26.250 1.00 7.78 N

ATOM 1067 CA HIS A 153 55.650 -5.095 26.542 1.00 7.51 C

ATOM 1068 CB HIS A 153 55.400 -4.869 28.042 1.00 7.78 C

ATOM 1069 CG HIS A 153 53.995 -4.445 28.355 1.00 8.06 C

ATOM 1070 NDl HIS A 153 52.909 -5.272 28.167 1.00 8.97 N

ATOM 1071 CEl HIS A 153 51.804 -4.631 28.507 1.00 9.00 C

ATOM 1072 NE2 HIS A 153 52.135 -3.416 28.908 1.00 8.59 N

ATOM 1073 CD2 HIS A 153 53.499 -3.274 28.823 1.00 8.98 C

ATOM 1074 C HIS A 153 55.114 -3.923 25.723 1.00 7.11 C

ATOM 1075 O HIS A 153 53.972 -3.965 25.285 1.00 6.98 O

ATOM 1076 N LEU A 154 55.929 -2.891 25.506 1.00 7.02 N

ATOM 1077 CA LEU A 154 55.464 -1.715 24.755 1.00 6.87 C

ATOM 1078 CB LEU A 154 56.410 -0.519 24.921 1.00 6.88 C

ATOM 1079 CG LEU A 154 56.442 0.086 26.335 1.00 6.58 C

ATOM 1080 CDl LEU A 154 57.543 1.121 26.455 1.00 7.02 C

ATOM 1081 CD2 LEU A 154 55.086 0.667 26.757 1.00 6.47 C

ATOM 1082 C LEU A 154 55.161 -2.006 23.276 1.00 6.96 C

ATOM 1083 O LEU A 154 54.331 -1.328 22.669 1.00 6.25 O

ATOM 1084 N PHE A 155 55.824 -3.019 22.716 1.00 6.84 N

ATOM 1085 CA PHE A 155 55.492 -3.519 21.379 1.00 6.86 C

ATOM 1086 CB PHE A 155 56.508 -4.568 20.909 1.00 6.81 C

ATOM 1087 CG PHE A 155 56.288 -5.041 19.498 1.00 7.41 C

ATOM 1088 CDl PHE A 155 56.264 -4.134 18.439 1.00 7.93 C

ATOM 1089 CEl PHE A 155 56.063 -4.566 17.128 1.00 8.19 C

ATOM 1090 CZ PHE A 155 55.889 -5.920 16.863 1.00 7.32 C

ATOM 1091 CE2 PHE A 155 55.909 -6.839 17.909 1.00 8.17 C

ATOM 1092 CD2 PHE A 155 56.116 -6.397 19.224 1.00 7.47 C

ATOM 1093 C PHE A 155 54.073 -4.088 21.332 1.00 6.62 C

ATOM 1094 O PHE A 155 53.313 -3.776 20.417 1.00 6.65 O

ATOM 1095 N THR A 156 53.728 -4.926 22.312 1.00 6.47 N

ATOM 1096 CA THR A 156 52.359 -5.412 22.466 1.00 6.46 C

ATOM 1097 CB THR A 156 52.183 -6.234 23.762 1.00 6.40 C

ATOM 1098 OGl THR A 156 53.237 -7.198 23.882 1.00 6.47 O

ATOM 1099 CG2 THR A 156 50.833 -6.954 23.777 1.00 6.27 C

ATOM 1100 C THR A 156 51.373 -4.234 22.486 1.00 6.27 C

ATOM 1101 O THR A 156 50.366 -4.249 21.775 1.00 6.34 O

ATOM 1102 N VAL A 157 51.678 -3.223 23.298 1.00 6.38 N

ATOM 1103 CA VAL A 157 50.803 -2.061 23.474 1.00 6.55 C

ATOM 1104 CB VAL A 157 51.303 -1.123 24.613 1.00 6.58 C

ATOM 1105 CGl VAL A 157 50.457 0.136 24.699 1.00 6.58 C

ATOM 1106 CG2 VAL A 157 51.288 -1.856 25.954 1.00 7.71 C

ATOM 1107 C VAL A 157 50.646 -1.299 22.157 1.00 6.55 C

ATOM 1108 O VAL A 157 49.525 -0.940 21.770 1.00 6.28 O

ATOM 1109 N LEU A 158 51.773 -1.075 21.479 1.00 6.27 N

ATOM 1110 CA LEU A 158 51.802 -0.464 20.152 1.00 6.68 C

ATOM 1111 CB LEU A 158 53.245 -0.400 19.617 1.00 6.50 C

ATOM 1112 CG LEU A 158 53.448 -0.057 18.134 1.00 6.85 C

ATOM 1113 CDl LEU A 158 53.128 1.409 17.831 1.00 7.35 C W2025-7029WO / AM102903-PCT

ATOM 1114 CD2 LEU A 158 54.863 -0.407 17.673 1.00 6.93 C

ATOM 1115 C LEU A 158 50.917 -1.201 19.147 1.00 6.78 C

ATOM 1116 O LEU A 158 50.119 -0.580 18.436 1.00 6.46 O

ATOM 1117 N VAL A 159 51.076 -2.522 19.088 1.00 6.81 N

ATOM 1118 CA VAL A 159 50.331 -3.343 18.140 1.00 7.09 C

ATOM 1119 CB VAL A 159 50.908 -4.778 18.021 1.00 6.96 C

ATOM 1120 CGl VAL A 159 50.054 -5.633 17.098 1.00 7.23 C

ATOM 1121 CG2 VAL A 159 52.337 -4.730 17.492 1.00 6.97 C

ATOM 1122 C VAL A 159 48.844 -3.344 18.499 1.00 7.13 C

ATOM 1123 O VAL A 159 48.002 -3.238 17.611 1.00 7.23 O

ATOM 1124 N GLN A 160 48.534 -3.430 19.794 1.00 7.55 N

ATOM 1125 CA GLN A 160 47.145 -3.338 20.276 1.00 8.16 C

ATOM 1126 CB GLN A 160 47.089 -3.409 21.809 1.00 8.13 C

ATOM 1127 CG GLN A 160 45.685 -3.215 22.388 1.00 8.87 C

ATOM 1128 CD GLN A 160 45.670 -2.942 23.885 1.00 9.84 C

ATOM 1129 OEl GLN A 160 46.685 -3.082 24.579 1.00 11.70 O

ATOM 1130 NE2 GLN A 160 44.502 -2.553 24.395 1.00 11.74 N

ATOM 1131 C GLN A 160 46.475 -2.046 19.790 1.00 8.05 C

ATOM 1132 O GLN A 160 45.388 -2.075 19.210 1.00 8.05 O

ATOM 1133 N GLU A 161 47.141 -0.921 20.028 1.00 7.88 N

ATOM 1134 CA GLU A 161 46.613 0.388 19.657 1.00 7.97 C

ATOM 1135 CB GLU A 161 47.455 1.501 20.289 1.00 7.83 C

ATOM 1136 CG GLU A 161 47.292 1.611 21.806 1.00 8.16 C

ATOM 1137 CD GLU A 161 48.319 2.534 22.459 1.00 7.83 C

ATOM 1138 OEl GLU A 161 49.178 3.105 21.749 1.00 7.08 O

ATOM 1139 OE2 GLU A 161 48.274 2.678 23.696 1.00 8.00 O

ATOM 1140 C GLU A 161 46.494 0.564 18.139 1.00 8.07 C

ATOM 1141 O GLU A 161 45.525 1.145 17.653 1.00 7.68 O

ATOM 1142 N MET A 162 47.463 0.041 17.392 1.00 8.47 N

ATOM 1143 CA MET A 162 47.393 0.088 15.933 1.00 9.41 C

ATOM 1144 CB MET A 162 48.697 -0.388 15.295 1.00 9.07 C

ATOM 1145 CG MET A 162 48.585 -0.544 13.786 1.00 10.16 C

ATOM 1146 SD MET A 162 50.107 -0.261 12.881 1.00 13.15

ATOM 1147 CE MET A 162 50.313 1.504 13.152 1.00 10.80 C

ATOM 1148 C MET A 162 46.189 -0.693 15.384 1.00 8.77 C

ATOM 1149 O MET A 162 45.452 -0.191 14.530 1.00 8.69 O

ATOM 1150 N ARG A 163 45.990 -1.909 15.888 1.00 8.50 N

ATOM 1151 CA ARG A 163 44.840 -2.736 15.515 1.00 8.44 C

ATOM 1152 CB ARG A 163 44.911 -4.105 16.225 1.00 8.22 C

ATOM 1153 CG ARG A 163 43.648 -4.986 16.132 1.00 8.16 C

ATOM 1154 CD ARG A 163 43.388 -5.499 14.715 1.00 8.75 C

ATOM 1155 NE ARG A 163 42.202 -6.357 14.643 1.00 7.95 N

ATOM 1156 CZ ARG A 163 42.209 -7.682 14.781 1.00 7.50 C

ATOM 1157 NHl ARG A 163 41.069 -8.360 14.692 1.00 7.05 N

ATOM 1158 NH2 ARG A 163 43.341 -8.337 15.013 1.00 7.70 N

ATOM 1159 C ARG A 163 43.514 -2.018 15.810 1.00 8.58 C

ATOM 1160 O ARG A 163 42.634 -1.957 14.948 1.00 8.20 O

ATOM 1161 N GLU A 164 43.396 -1.474 17.022 1.00 8.80 N

ATOM 1162 CA GLU A 164 42.210 -0.715 17.452 1.00 9.37 C

ATOM 1163 CB GLU A 164 42.364 -0.242 18.902 1.00 9.05 C

ATOM 1164 CG GLU A 164 42.166 -1.335 19.937 1.00 9.70 C

ATOM 1165 CD GLU A 164 42.613 -0.927 21.332 1.00 10.54 C

ATOM 1166 OEl GLU A 164 42.667 -1.813 22.210 1.00 11.08 O

ATOM 1167 OE2 GLU A 164 42.930 0.268 21.553 1.00 13.36 O

ATOM 1168 C GLU A 164 41.908 0.485 16.555 1.00 9.07 C

ATOM 1169 O GLU A 164 40.761 0.699 16.173 1.00 9.21 O

ATOM 1170 N ALA A 165 42.941 1.262 16.233 1.00 8.96 N

ATOM 1171 CA ALA A 165 42.791 2.440 15.377 1.00 8.85 C

ATOM 1172 CB ALA A 165 44.065 3.276 15.383 1.00 8.85 C

ATOM 1173 C ALA A 165 42.406 2.050 13.948 1.00 8.50 C

ATOM 1174 O ALA A 165 41.585 2.721 13.322 1.00 8.42 O

ATOM 1175 N PHE A 166 42.992 0.963 13.447 1.00 8.36 N

ATOM 1176 CA PHE A 166 42.615 0.394 12.141 1.00 8.24 C W2025-7029WO / AM102903-PCT

ATOM 1177 CB PHE A 166 43.518 -0.789 11.783 1.00 8.04 C

ATOM 1178 CG PHE A 166 44.898 -0.394 11.313 1.00 8.07 C

ATOM 1179 CDl PHE A 166 45.331 0.932 11.364 1.00 7.46 C

ATOM 1180 CEl PHE A 166 46.610 1.283 10.931 1.00 7.72 C

ATOM 1181 CZ PHE A 166 47.470 0.303 10.459 1.00 8.04 C

ATOM 1182 CE2 PHE A 166 47.054 -1.023 10.421 1.00 8.19 C

ATOM 1183 CD2 PHE A 166 45.779 -1.363 10.849 1.00 8.04 C

ATOM 1184 C PHE A 166 41.146 -0.037 12.115 1.00 8.15 C

ATOM 1185 O PHE A 166 40.429 0.228 11.148 1.00 7.77 O

ATOM 1186 N GLU A 167 40.713 -0.691 13.191 1.00 8.46 N

ATOM 1187 CA GLU A 167 39.328 -1.144 13.338 1.00 8.81 C

ATOM 1188 CB GLU A 167 39.143 -1.927 14.643 1.00 8.67 C

ATOM 1189 CG GLU A 167 39.796 -3.316 14.681 1.00 9.03 C

ATOM 1190 CD GLU A 167 38.964 -4.409 14.016 1.00 9.16 C

ATOM 1191 OEl GLU A 167 37.800 -4.147 13.624 1.00 9.42 O

ATOM 1192 OE2 GLU A 167 39.484 -5.545 13.886 1.00 8.57 O

ATOM 1193 C GLU A 167 38.370 0.044 13.302 1.00 8.82 C

ATOM 1194 O GLU A 167 37.359 0.007 12.602 1.00 8.82 O

ATOM 1195 N GLN A 168 38.712 1.094 14.047 1.00 9.19 N

ATOM 1196 CA GLN A 168 37.891 2.305 14.119 1.00 9.64 C

ATOM 1197 CB GLN A 168 38.354 3.214 15.262 1.00 9.62 C

ATOM 1198 CG GLN A 168 38.206 2.623 16.658 1.00 10.56 C

ATOM 1199 CD GLN A 168 36.763 2.519 17.116 1.00 11.95 C

ATOM 1200 OEl GLN A 168 35.966 1.769 16.550 1.00 12.11 O

ATOM 1201 NE2 GLN A 168 36.424 3.264 18.158 1.00 13.32 N

ATOM 1202 C GLN A 168 37.862 3.074 12.796 1.00 9.66 C

ATOM 1203 O GLN A 168 36.800 3.507 12.356 1.00 9.49 O

ATOM 1204 N GLU A 169 39.023 3.224 12.161 1.00 10.11 N

ATOM 1205 CA GLU A 169 39.128 3.948 10.888 1.00 10.42 C

ATOM 1206 CB GLU A 169 40.586 4.033 10.420 1.00 10.61 C

ATOM 1207 CG GLU A 169 40.795 4.917 9.177 1.00 10.62 C

ATOM 1208 CD GLU A 169 40.938 4.136 7.869 1.00 10.78 C

ATOM 1209 OEl GLU A 169 40.597 2.933 7.810 1.00 10.92 O

ATOM 1210 OE2 GLU A 169 41.401 4.741 6.880 1.00 11.11 O

ATOM 1211 C GLU A 169 38.264 3.323 9.795 1.00 10.78 C

ATOM 1212 O GLU A 169 37.689 4.038 8.971 1.00 10.35 O

ATOM 1213 N ALA A 170 38.187 1.989 9.803 1.00 11.38 N

ATOM 1214 CA ALA A 170 37.406 1.224 8.831 1.00 12.21 C

ATOM 1215 CB ALA A 170 37.550 -0.277 9.099 1.00 11.96 C

ATOM 1216 C ALA A 170 35.935 1.623 8.848 1.00 12.92 C

ATOM 1217 O ALA A 170 35.299 1.709 7.800 1.00 12.80 O

ATOM 1218 N LYS A 171 35.410 1.861 10.046 1.00 14.00 N

ATOM 1219 CA LYS A 171 34.023 2.288 10.238 1.00 15.19 C

ATOM 1220 CB LYS A 171 33.606 2.087 11.698 1.00 15.48 C

ATOM 1221 CG LYS A 171 33.663 0.645 12.182 1.00 16.53 C

ATOM 1222 CD LYS A 171 32.459 -0.150 11.707 1.00 19.33 C

ATOM 1223 CE LYS A 171 32.773 -1.635 11.635 1.00 20.81 C

ATOM 1224 NZ LYS A 171 31.566 -2.421 11.245 1.00 22.21 N

ATOM 1225 C LYS A 171 33.823 3.750 9.846 1.00 15.63 C

ATOM 1226 O LYS A 171 32.727 4.145 9.438 1.00 16.05 O

ATOM 1227 N GLN A 172 34.887 4.543 9.980 1.00 15.78 N

ATOM 1228 CA GLN A 172 34.862 5.966 9.656 1.00 16.29 C

ATOM 1229 CB GLN A 172 36.064 6.685 10.287 1.00 16.20 C

ATOM 1230 CG GLN A 172 36.066 8.201 10.112 1.00 17.27 C

ATOM 1231 CD GLN A 172 37.418 8.849 10.412 1.00 17.87 C

ATOM 1232 OEl GLN A 172 38.468 8.189 10.408 1.00 20.05 O

ATOM 1233 NE2 GLN A 172 37.396 10.158 10.670 1.00 19.97 N

ATOM 1234 C GLN A 172 34.818 6.214 8.147 1.00 15.73 C

ATOM 1235 O GLN A 172 34.033 7.041 7.680 1.00 15.95 O

ATOM 1236 N ILE A 173 35.659 5.508 7.389 1.00 15.16 N

ATOM 1237 CA ILE A 173 35.701 5.704 5.930 1.00 14.62 C

ATOM 1238 CB ILE A 173 37.142 5.895 5.386 1.00 14.80 C

ATOM 1239 CGl ILE A 173 37.976 4.627 5.562 1.00 15.30 C W2025-7029WO / AM102903-PCT

ATOM 1240 CDl ILE A 173 39.160 4.570 4.620 1.00 16.88 C

ATOM 1241 CG2 ILE A 173 37.797 7.106 6.037 1.00 15.84 C

ATOM 1242 C ILE A 173 34.955 4.633 5.129 1.00 13.72 C

ATOM 1243 O ILE A 173 34.984 4.642 3.896 1.00 13.20 O

ATOM 1244 N ASN A 174 34.283 3.730 5.846 1.00 12.71 N

ATOM 1245 CA ASN A 174 33.451 2.673 5.254 1.00 12.27 C

ATOM 1246 CB ASN A 174 32.153 3.262 4.667 1.00 12.70 C

ATOM 1247 CG ASN A 174 31.265 3.897 5.731 1.00 13.88 C

ATOM 1248 ODl ASN A 174 30.858 3.241 6.692 1.00 16.87 O

ATOM 1249 ND2 ASN A 174 30.958 5.174 5.560 1.00 15.39 N

ATOM 1250 C ASN A 174 34.201 1.797 4.240 1.00 11.41 C

ATOM 1251 O ASN A 174 33.745 1.587 3.113 1.00 10.74 O

ATOM 1252 N LYS A 175 35.367 1.308 4.659 1.00 10.47 N

ATOM 1253 CA LYS A 175 36.186 0.400 3.849 1.00 10.07 C

ATOM 1254 CB LYS A 175 37.381 1.140 3.236 1.00 10.06 C

ATOM 1255 CG LYS A 175 37.029 2.227 2.237 1.00 10.79 C

ATOM 1256 CD LYS A 175 38.286 2.744 1.557 1.00 12.15 C

ATOM 1257 CE LYS A 175 38.008 3.978 0.710 1.00 13.03 C

ATOM 1258 NZ LYS A 175 39.117 4.215 -0.259 1.00 14.45 N

ATOM 1259 C LYS A 175 36.692 -0.737 4.737 1.00 9.40 C

ATOM 1260 O LYS A 175 36.721 -0.583 5.958 1.00 9.19 O

ATOM 1261 N PRO A 176 37.082 -1.883 4.134 1.00 8.90 N

ATOM 1262 CA PRO A 176 37.729 -2.935 4.920 1.00 8.62 C

ATOM 1263 CB PRO A 176 38.202 -3.926 3.853 1.00 8.53 C

ATOM 1264 CG PRO A 176 37.211 -3.765 2.755 1.00 9.07 C

ATOM 1265 CD PRO A 176 36.924 -2.284 2.722 1.00 8.68 C

ATOM 1266 C PRO A 176 38.920 -2.413 5.726 1.00 8.45 C

ATOM 1267 O PRO A 176 39.652 -1.516 5.277 1.00 8.08 O

ATOM 1268 N ARG A 177 39.078 -2.976 6.917 1.00 8.17 N

ATOM 1269 CA ARG A 177 40.150 -2.644 7.840 1.00 8.50 C

ATOM 1270 CB ARG A 177 40.022 -3.534 9.089 1.00 8.67 C

ATOM 1271 CG ARG A 177 41.170 -3.463 10.065 1.00 9.24 C

ATOM 1272 CD ARG A 177 40.922 -4.259 11.337 1.00 8.78 C

ATOM 1273 NE ARG A 177 40.908 -5.720 11.185 1.00 9.27 N

ATOM 1274 CZ ARG A 177 41.991 -6.498 11.157 1.00 10.03 C

ATOM 1275 NHl ARG A 177 43.213 -5.976 11.223 1.00 9.32 N

ATOM 1276 NH2 ARG A 177 41.854 -7.812 11.040 1.00 10.76 N

ATOM 1277 C ARG A 177 41.526 -2.818 7.189 1.00 8.32 C

ATOM 1278 O ARG A 177 41.736 -3.739 6.400 1.00 8.50 O

ATOM 1279 N LEU A 178 42.447 -1.916 7.519 1.00 8.27 N

ATOM 1280 CA LEU A 178 43.859 -2.095 7.201 1.00 8.25 C

ATOM 1281 CB LEU A 178 44.654 -0.807 7.476 1.00 7.82 C

ATOM 1282 CG LEU A 178 44.462 0.431 6.577 1.00 8.19 C

ATOM 1283 CDl LEU A 178 44.967 1.699 7.268 1.00 6.23 C

ATOM 1284 CD2 LEU A 178 45.135 0.263 5.208 1.00 6.71 C

ATOM 1285 C LEU A 178 44.416 -3.254 8.033 1.00 8.28 C

ATOM 1286 O LEU A 178 43.973 -3.492 9.164 1.00 8.24 O

ATOM 1287 N MET A 179 45.376 -3.973 7.462 1.00 8.44 N

ATOM 1288 CA MET A 179 46.005 -5.116 8.123 1.00 9.32 C

ATOM 1289 CB MET A 179 46.518 -6.114 7.083 1.00 9.09 C

ATOM 1290 CG MET A 179 45.459 -6.950 6.387 1.00 10.37 C

ATOM 1291 SD MET A 179 46.222 -7.994 5.114 1.00 13.31

ATOM 1292 CE MET A 179 47.364 -8.963 6.101 1.00 11.34 C

ATOM 1293 C MET A 179 47.190 -4.671 8.975 1.00 8.21 C

ATOM 1294 O MET A 179 47.873 -3.703 8.645 1.00 7.94 O

ATOM 1295 N VAL A 180 47.440 -5.402 10.055 1.00 7.52 N

ATOM 1296 CA VAL A 180 48.651 -5.219 10.843 1.00 6.98 C

ATOM 1297 CB VAL A 180 48.367 -4.511 12.207 1.00 6.90 C

ATOM 1298 CGl VAL A 180 47.373 -5.307 13.068 1.00 6.99 C

ATOM 1299 CG2 VAL A 180 49.668 -4.230 12.964 1.00 7.61 C

ATOM 1300 C VAL A 180 49.381 -6.562 11.008 1.00 6.63 C

ATOM 1301 O VAL A 180 48.806 -7.541 11.491 1.00 6.19 O

ATOM 1302 N THR A 181 50.641 -6.602 10.572 1.00 6.11 N W2025-7029WO / AM102903-PCT

ATOM 1303 CA THR A 181 51.467 -7.806 10.685 1.00 5.72 C

ATOM 1304 CB THR A 181 51.623 -8.547 9.316 1.00 5.71 C

ATOM 1305 OGl THR A 181 52.370 -7.739 8.397 1.00 4.85 O

ATOM 1306 CG2 THR A 181 50.260 -8.900 8.706 1.00 5.43 C

ATOM 1307 C THR A 181 52.851 -7.461 11.246 1.00 5.61 C

ATOM 1308 O THR A 181 53.192 -6.283 11.399 1.00 5.06 O

ATOM 1309 N ALA A 182 53.639 -8.487 11.568 1.00 5.44 N

ATOM 1310 CA ALA A 182 55.018 -8.269 12.015 1.00 5.52 C

ATOM 1311 CB ALA A 182 55.080 -8.064 13.533 1.00 5.83 C

ATOM 1312 C ALA A 182 55.970 -9.374 11.592 1.00 5.34 C

ATOM 1313 O ALA A 182 55.614 -10.551 11.605 1.00 5.25 O

ATOM 1314 N ALA A 183 57.172 -8.972 11.187 1.00 5.44 N

ATOM 1315 CA ALA A 183 58.286 -9.901 11.035 1.00 5.29 C

ATOM 1316 CB ALA A 183 59.306 -9.375 10.029 1.00 5.34 C

ATOM 1317 C ALA A 183 58.924 -10.060 12.404 1.00 5.18 C

ATOM 1318 O ALA A 183 59.182 -9.066 13.087 1.00 4.92 O

ATOM 1319 N VAL A 184 59.175 -11.307 12.807 1.00 4.79 N

ATOM 1320 CA VAL A 184 59.639 -11.589 14.167 1.00 4.49 C

ATOM 1321 CB VAL A 184 58.521 -12.235 15.031 1.00 4.55 C

ATOM 1322 CGl VAL A 184 57.363 -11.258 15.232 1.00 4.01 C

ATOM 1323 CG2 VAL A 184 58.035 -13.548 14.400 1.00 3.66 C

ATOM 1324 C VAL A 184 60.883 -12.475 14.198 1.00 4.58 C

ATOM 1325 O VAL A 184 61.156 -13.200 13.241 1.00 4.90 O

ATOM 1326 N ALA A 185 61.605 -12.424 15.315 1.00 4.62 N

ATOM 1327 CA ALA A 185 62.851 -13.178 15.506 1.00 4.99 C

ATOM 1328 CB ALA A 185 63.497 -12.795 16.830 1.00 4.88 C

ATOM 1329 C ALA A 185 62.666 -14.695 15.439 1.00 5.05 C

ATOM 1330 O ALA A 185 61.613 -15.218 15.816 1.00 4.80 O

ATOM 1331 N ALA A 186 63.698 -15.378 14.947 1.00 5.24 N

ATOM 1332 CA ALA A 186 63.790 -16.841 14.998 1.00 5.81 C

ATOM 1333 CB ALA A 186 64.210 -17.407 13.635 1.00 5.45 C

ATOM 1334 C ALA A 186 64.741 -17.328 16.100 1.00 6.03 C

ATOM 1335 O ALA A 186 64.684 -18.485 16.506 1.00 6.05 O

ATOM 1336 N GLY A 187 65.610 -16.441 16.583 1.00 6.71 N

ATOM 1337 CA GLY A 187 66.523 -16.774 17.679 1.00 7.44 C

ATOM 1338 C GLY A 187 65.776 -16.862 18.995 1.00 7.91 C

ATOM 1339 O GLY A 187 65.012 -15.964 19.340 1.00 8.23 O

ATOM 1340 N ILE A 188 65.999 -17.944 19.735 1.00 8.47 N

ATOM 1341 CA ILE A 188 65.224 -18.224 20.945 1.00 8.67 C

ATOM 1342 CB ILE A 188 65.537 -19.629 21.520 1.00 8.59 C

ATOM 1343 CGl ILE A 188 65.324 -20.717 20.452 1.00 8.55 C

ATOM 1344 CDl ILE A 188 63.901 -20.806 19.848 1.00 7.67 C

ATOM 1345 CG2 ILE A 188 64.713 -19.903 22.802 1.00 8.26 C

ATOM 1346 C ILE A 188 65.372 -17.152 22.023 1.00 9.06 C

ATOM 1347 O ILE A 188 64.371 -16.708 22.586 1.00 8.98 O

ATOM 1348 N SER A 189 66.604 -16.727 22.306 1.00 9.37 N

ATOM 1349 CA SER A 189 66.812 -15.664 23.293 1.00 9.79 C

ATOM 1350 CB SER A 189 68.289 -15.507 23.684 1.00 9.70 C

ATOM 1351 OG SER A 189 69.069 -15.048 22.602 1.00 11.81 O

ATOM 1352 C SER A 189 66.192 -14.334 22.851 1.00 9.60 C

ATOM 1353 O SER A 189 65.623 -13.626 23.675 1.00 9.38 O

ATOM 1354 N ASN A 190 66.279 -14.015 21.557 1.00 9.71 N

ATOM 1355 CA ASN A 190 65.641 -12.812 21.008 1.00 9.85 C

ATOM 1356 CB ASN A 190 66.029 -12.578 19.542 1.00 10.04 C

ATOM 1357 CG ASN A 190 67.515 -12.322 19.344 1.00 10.92 C

ATOM 1358 ODl ASN A 190 68.210 -11.809 20.228 1.00 12.53 O

ATOM 1359 ND2 ASN A 190 68.004 -12.654 18.157 1.00 11.24 N

ATOM 1360 C ASN A 190 64.116 -12.886 21.120 1.00 9.98 C

ATOM 1361 O ASN A 190 63.462 -11.882 21.403 1.00 10.18 O

ATOM 1362 N ILE A 191 63.564 -14.080 20.890 1.00 10.00 N

ATOM 1363 CA ILE A 191 62.128 -14.330 21.035 1.00 9.80 C

ATOM 1364 CB ILE A 191 61.746 -15.772 20.588 1.00 9.68 C

ATOM 1365 CGl ILE A 191 61.805 -15.901 19.065 1.00 9.38 C W2025-7029WO / AM102903-PCT

ATOM 1366 CDl ILE A 191 61.814 -17.332 18.565 1.00 9.59 C

ATOM 1367 CG2 ILE A 191 60.347 -16.153 21.097 1.00 9.13 C

ATOM 1368 C ILE A 191 61.697 -14.107 22.487 1.00 9.99 C

ATOM 1369 O ILE A 191 60.716 -13.408 22.755 1.00 9.99 O

ATOM 1370 N GLN A 192 62.451 -14.694 23.415 1.00 9.96 N

ATOM 1371 CA GLN A 192 62.137 -14.625 24.843 1.00 9.91 C

ATOM 1372 CB GLN A 192 63.003 -15.622 25.624 1.00 10.06 C

ATOM 1373 CG GLN A 192 62.599 -17.086 25.391 1.00 10.14 C

ATOM 1374 CD GLN A 192 63.537 -18.094 26.034 1.00 10.47 C

ATOM 1375 OEl GLN A 192 64.717 -17.820 26.256 1.00 11.55 O

ATOM 1376 NE2 GLN A 192 63.014 -19.277 26.324 1.00 11.83 N

ATOM 1377 C GLN A 192 62.258 -13.216 25.428 1.00 9.77 C

ATOM 1378 O GLN A 192 61.493 -12.846 26.327 1.00 9.95 O

ATOM 1379 N SER A 193 63.197 -12.422 24.918 1.00 9.22 N

ATOM 1380 CA SER A 193 63.336 -11.045 25.386 1.00 8.95 C

ATOM 1381 CB SER A 193 64.814 -10.627 25.440 1.00 9.26 C

ATOM 1382 OG SER A 193 65.391 -10.514 24.147 1.00 9.94 O

ATOM 1383 C SER A 193 62.498 -10.035 24.583 1.00 8.68 C

ATOM 1384 O SER A 193 62.432 -8.854 24.942 1.00 8.77 O

ATOM 1385 N GLY A 194 61.842 -10.502 23.522 1.00 8.16 N

ATOM 1386 CA GLY A 194 61.184 -9.606 22.578 1.00 7.94 C

ATOM 1387 C GLY A 194 59.668 -9.555 22.550 1.00 7.90 C

ATOM 1388 O GLY A 194 59.091 -8.497 22.277 1.00 8.06 O

ATOM 1389 N TYR A 195 59.012 -10.683 22.813 1.00 7.66 N

ATOM 1390 CA TYR A 195 57.569 -10.770 22.574 1.00 7.45 C

ATOM 1391 CB TYR A 195 57.281 -11.470 21.236 1.00 7.25 C

ATOM 1392 CG TYR A 195 58.227 -11.091 20.112 1.00 6.78 C

ATOM 1393 CDl TYR A 195 59.369 -11.846 19.863 1.00 6.55 C

ATOM 1394 CEl TYR A 195 60.247 -11.509 18.844 1.00 7.29 C

ATOM 1395 CZ TYR A 195 59.989 -10.408 18.052 1.00 6.29 C

ATOM 1396 OH TYR A 195 60.875 -10.094 17.045 1.00 6.66 O

ATOM 1397 CE2 TYR A 195 58.863 -9.633 18.275 1.00 5.69 C

ATOM 1398 CD2 TYR A 195 57.985 -9.976 19.305 1.00 6.26 C

ATOM 1399 C TYR A 195 56.749 -11.425 23.690 1.00 7.45 C

ATOM 1400 O TYR A 195 57.148 -12.437 24.272 1.00 7.59 O

ATOM 1401 N GLU A 196 55.603 -10.817 23.982 1.00 7.44 N

ATOM 1402 CA GLU A 196 54.585 -11.432 24.821 1.00 7.45 C

ATOM 1403 CB GLU A 196 53.823 -10.366 25.610 1.00 7.34 C

ATOM 1404 CG GLU A 196 54.725 -9.405 26.373 1.00 7.34 C

ATOM 1405 CD GLU A 196 53.958 -8.332 27.107 1.00 7.76 C

ATOM 1406 OEl GLU A 196 54.259 -8.129 28.300 1.00 7.68 O

ATOM 1407 OE2 GLU A 196 53.052 -7.703 26.507 1.00 7.93 O

ATOM 1408 C GLU A 196 53.657 -12.175 23.866 1.00 7.25 C

ATOM 1409 O GLU A 196 52.666 -11.610 23.387 1.00 7.05 O

ATOM 1410 N ILE A 197 53.998 -13.436 23.585 1.00 7.22 N

ATOM 1411 CA ILE A 197 53.423 -14.176 22.447 1.00 7.10 C

ATOM 1412 CB ILE A 197 54.159 -15.516 22.162 1.00 7.16 C

ATOM 1413 CGl ILE A 197 55.634 -15.240 21.823 1.00 6.71 C

ATOM 1414 CDl ILE A 197 56.521 -16.482 21.746 1.00 7.16 C

ATOM 1415 CG2 ILE A 197 53.478 -16.275 21.026 1.00 6.88 C

ATOM 1416 C ILE A 197 51.897 -14.343 22.485 1.00 7.33 C

ATOM 1417 O ILE A 197 51.231 -13.972 21.516 1.00 7.69 O

ATOM 1418 N PRO A 198 51.339 -14.911 23.581 1.00 7.15 N

ATOM 1419 CA PRO A 198 49.883 -15.072 23.608 1.00 7.24 C

ATOM 1420 CB PRO A 198 49.615 -15.604 25.021 1.00 7.18 C

ATOM 1421 CG PRO A 198 50.871 -16.309 25.376 1.00 7.41 C

ATOM 1422 CD PRO A 198 51.952 -15.434 24.815 1.00 7.09 C

ATOM 1423 C PRO A 198 49.113 -13.770 23.355 1.00 6.86 C

ATOM 1424 O PRO A 198 48.207 -13.765 22.521 1.00 7.02 O

ATOM 1425 N GLN A 199 49.469 -12.684 24.048 1.00 6.56 N

ATOM 1426 CA GLN A 199 48.730 -11.419 23.898 1.00 6.23 C

ATOM 1427 CB GLN A 199 48.994 -10.449 25.063 1.00 6.47 C

ATOM 1428 CG GLN A 199 48.060 -9.230 25.090 1.00 6.60 C W2025-7029WO / AM102903-PCT

ATOM 1429 CD GLN A 199 46.589 -9.607 25.221 1.00 7.89 C

ATOM 1430 OEl GLN A 199 46.083 -9.818 26.324 1.00 8.73 O

ATOM 1431 NE2 GLN A 199 45.898 -9.694 24.090 1.00 8.45 N

ATOM 1432 C GLN A 199 48.977 -10.731 22.546 1.00 6.00 C

ATOM 1433 O GLN A 199 48.037 -10.252 21.906 1.00 5.19 O

ATOM 1434 N LEU A 200 50.240 -10.691 22.119 1.00 5.77 N

ATOM 1435 CA LEU A 200 50.597 -10.093 20.836 1.00 5.77 C

ATOM 1436 CB LEU A 200 52.115 -10.130 20.620 1.00 5.52 C

ATOM 1437 CG LEU A 200 52.699 -9.518 19.340 1.00 6.20 C

ATOM 1438 CDl LEU A 200 52.572 -7.991 19.328 1.00 5.62 C

ATOM 1439 CD2 LEU A 200 54.156 -9.931 19.173 1.00 5.09 C

ATOM 1440 C LEU A 200 49.865 -10.771 19.674 1.00 5.99 C

ATOM 1441 O LEU A 200 49.405 -10.098 18.751 1.00 6.03 O

ATOM 1442 N SER A 201 49.750 -12.100 19.738 1.00 6.38 N

ATOM 1443 CA SER A 201 49.147 -12.895 18.663 1.00 6.82 C

ATOM 1444 CB SER A 201 49.406 -14.388 18.886 1.00 6.89 C

ATOM 1445 OG SER A 201 50.799 -14.658 18.934 1.00 7.07 O

ATOM 1446 C SER A 201 47.646 -12.647 18.474 1.00 7.11 C

ATOM 1447 O SER A 201 47.091 -12.971 17.422 1.00 7.17 O

ATOM 1448 N GLN A 202 46.997 -12.083 19.490 1.00 7.16 N

ATOM 1449 CA GLN A 202 45.581 -11.724 19.389 1.00 7.55 C

ATOM 1450 CB GLN A 202 44.944 -11.549 20.780 1.00 7.66 C

ATOM 1451 CG GLN A 202 45.073 -12.733 21.747 1.00 8.52 C

ATOM 1452 CD GLN A 202 44.845 -14.096 21.097 1.00 10.64 C

ATOM 1453 OEl GLN A 202 43.825 -14.332 20.441 1.00 11.08 O

ATOM 1454 NE2 GLN A 202 45.802 -15.005 21.287 1.00 10.30 N

ATOM 1455 C GLN A 202 45.329 -10.469 18.527 1.00 7.36 C

ATOM 1456 O GLN A 202 44.216 -10.269 18.033 1.00 7.40 O

ATOM 1457 N TYR A 203 46.355 -9.637 18.345 1.00 7.33 N

ATOM 1458 CA TYR A 203 46.215 -8.378 17.586 1.00 7.33 C

ATOM 1459 CB TYR A 203 46.861 -7.207 18.344 1.00 7.67 C

ATOM 1460 CG TYR A 203 46.428 -7.076 19.792 1.00 8.19 C

ATOM 1461 CDl TYR A 203 47.364 -7.098 20.825 1.00 8.98 C

ATOM 1462 CEl TYR A 203 46.968 -6.980 22.159 1.00 9.87 C

ATOM 1463 CZ TYR A 203 45.618 -6.844 22.463 1.00 9.19 C

ATOM 1464 OH TYR A 203 45.204 -6.724 23.773 1.00 8.77 O

ATOM 1465 CE2 TYR A 203 44.677 -6.825 21.455 1.00 9.02 C

ATOM 1466 CD2 TYR A 203 45.084 -6.937 20.128 1.00 8.98 C

ATOM 1467 C TYR A 203 46.754 -8.442 16.150 1.00 7.04 C

ATOM 1468 O TYR A 203 46.151 -7.874 15.224 1.00 7.13 O

ATOM 1469 N LEU A 204 47.886 -9.121 15.969 1.00 6.51 N

ATOM 1470 CA LEU A 204 48.509 -9.280 14.652 1.00 6.17 C

ATOM 1471 CB LEU A 204 49.907 -9.899 14.785 1.00 5.78 C

ATOM 1472 CG LEU A 204 51.045 -9.057 15.378 1.00 6.08 C

ATOM 1473 CDl LEU A 204 52.280 -9.931 15.635 1.00 4.39 C

ATOM 1474 CD2 LEU A 204 51.391 -7.895 14.455 1.00 4.97 C

ATOM 1475 C LEU A 204 47.656 -10.172 13.754 1.00 5.96 C

ATOM 1476 O LEU A 204 47.147 -11.198 14.205 1.00 6.05 O

ATOM 1477 N ASP A 205 47.516 -9.786 12.488 1.00 5.55 N

ATOM 1478 CA ASP A 205 46.825 -10.624 11.502 1.00 5.36 C

ATOM 1479 CB ASP A 205 46.352 -9.779 10.312 1.00 5.30 C

ATOM 1480 CG ASP A 205 45.271 -8.776 10.707 1.00 5.48 C

ATOM 1481 ODl ASP A 205 44.245 -9.191 11.291 1.00 5.13 O

ATOM 1482 OD2 ASP A 205 45.452 -7.573 10.442 1.00 3.88 O

ATOM 1483 C ASP A 205 47.693 -11.800 11.049 1.00 5.40 C

ATOM 1484 O ASP A 205 47.201 -12.922 10.880 1.00 4.85 O

ATOM 1485 N TYR A 206 48.984 -11.523 10.863 1.00 5.42 N

ATOM 1486 CA TYR A 206 49.983 -12.528 10.489 1.00 5.55 C

ATOM 1487 CB TYR A 206 50.176 -12.594 8.964 1.00 6.07 C

ATOM 1488 CG TYR A 206 48.949 -13.101 8.247 1.00 6.89 C

ATOM 1489 CDl TYR A 206 48.086 -12.219 7.595 1.00 6.78 C

ATOM 1490 CEl TYR A 206 46.935 -12.684 6.955 1.00 7.92 C

ATOM 1491 CZ TYR A 206 46.639 -14.037 6.983 1.00 7.27 C W2025-7029WO / AM102903-PCT

ATOM 1492 OH TYR A 206 45.507 -14.512 6.355 1.00 8.73 O

ATOM 1493 CE2 TYR A 206 47.475 -14.925 7.631 1.00 7.95 C

ATOM 1494 CD2 TYR A 206 48.620 -14.455 8.265 1.00 7.00 C

ATOM 1495 C TYR A 206 51.313 -12.275 11.186 1.00 5.14 C

ATOM 1496 O TYR A 206 51.678 -11.124 11.461 1.00 5.17 O

ATOM 1497 N ILE A 207 52.008 -13.371 11.479 1.00 4.80 N

ATOM 1498 CA ILE A 207 53.298 -13.377 12.150 1.00 4.40 C

ATOM 1499 CB ILE A 207 53.238 -14.175 13.491 1.00 4.58 C

ATOM 1500 CGl ILE A 207 52.192 -13.558 14.444 1.00 3.82 C

ATOM 1501 CDl ILE A 207 51.612 -14.546 15.467 1.00 5.11 C

ATOM 1502 CG2 ILE A 207 54.600 -14.191 14.176 1.00 3.90 C

ATOM 1503 C ILE A 207 54.311 -13.991 11.183 1.00 4.61 C

ATOM 1504 O ILE A 207 54.262 -15.194 10.900 1.00 4.59 O

ATOM 1505 N HIS A 208 55.199 -13.147 10.661 1.00 4.35 N

ATOM 1506 CA HIS A 208 56.178 -13.552 9.657 1.00 4.56 C

ATOM 1507 CB HIS A 208 56.427 -12.417 8.646 1.00 4.46 C

ATOM 1508 CG HIS A 208 55.185 -11.912 7.973 1.00 4.12 C

ATOM 1509 NDl HIS A 208 54.837 -10.576 7.956 1.00 4.06 N

ATOM 1510 CEl HIS A 208 53.701 -10.427 7.296 1.00 3.46 C

ATOM 1511 NE2 HIS A 208 53.299 -11.616 6.883 1.00 3.82 N

ATOM 1512 CD2 HIS A 208 54.210 -12.562 7.293 1.00 3.32 C

ATOM 1513 C HIS A 208 57.475 -13.926 10.367 1.00 4.57 C

ATOM 1514 O HIS A 208 58.273 -13.055 10.716 1.00 4.42 O

ATOM 1515 N VAL A 209 57.671 -15.222 10.603 1.00 4.38 N

ATOM 1516 CA VAL A 209 58.832 -15.673 11.371 1.00 4.63 C

ATOM 1517 CB VAL A 209 58.583 -17.028 12.093 1.00 4.51 C

ATOM 1518 CGl VAL A 209 59.709 -17.323 13.070 1.00 4.49 C

ATOM 1519 CG2 VAL A 209 57.240 -17.015 12.833 1.00 4.08 C

ATOM 1520 C VAL A 209 60.047 -15.757 10.451 1.00 4.75 C

ATOM 1521 O VAL A 209 60.009 -16.444 9.422 1.00 4.55 O

ATOM 1522 N MET A 210 61.113 -15.052 10.830 1.00 4.92 N

ATOM 1523 CA MET A 210 62.312 -14.922 9.989 1.00 5.40 C

ATOM 1524 CB MET A 210 63.040 -13.600 10.283 1.00 5.23 C

ATOM 1525 CG MET A 210 62.269 -12.349 9.856 1.00 4.99 C

ATOM 1526 SD MET A 210 63.155 -10.804 10.196 1.00 7.65 S

ATOM 1527 CE MET A 210 62.905 -10.654 11.947 1.00 4.49 C

ATOM 1528 C MET A 210 63.247 -16.125 10.146 1.00 4.94 C

ATOM 1529 O MET A 210 64.366 -16.003 10.663 1.00 4.84 O

ATOM 1530 N THR A 211 62.777 -17.281 9.681 1.00 4.78 N

ATOM 1531 CA THR A 211 63.506 -18.551 9.810 1.00 5.07 C

ATOM 1532 CB THR A 211 62.555 -19.776 9.792 1.00 5.09 C

ATOM 1533 OGl THR A 211 61.576 -19.617 8.755 1.00 4.59 O

ATOM 1534 CG2 THR A 211 61.849 -19.927 11.124 1.00 5.31 C

ATOM 1535 C THR A 211 64.591 -18.694 8.742 1.00 5.24 C

ATOM 1536 O THR A 211 64.551 -19.597 7.895 1.00 5.73 O

ATOM 1537 N TYR A 212 65.542 -17.765 8.783 1.00 5.09 N

ATOM 1538 CA TYR A 212 66.725 -17.775 7.929 1.00 4.72 C

ATOM 1539 CB TYR A 212 66.428 -17.179 6.539 1.00 4.77 C

ATOM 1540 CG TYR A 212 65.476 -15.995 6.519 1.00 4.93 C

ATOM 1541 CDl TYR A 212 65.904 -14.721 6.901 1.00 4.44 C

ATOM 1542 CEl TYR A 212 65.032 -13.629 6.879 1.00 4.97 C

ATOM 1543 CZ TYR A 212 63.720 -13.807 6.459 1.00 4.82 C

ATOM 1544 OH TYR A 212 62.865 -12.725 6.431 1.00 5.06 O

ATOM 1545 CE2 TYR A 212 63.273 -15.060 6.065 1.00 4.88 C

ATOM 1546 CD2 TYR A 212 64.149 -16.148 6.102 1.00 4.81 C

ATOM 1547 C TYR A 212 67.860 -17.036 8.657 1.00 4.54 C

ATOM 1548 O TYR A 212 67.648 -16.503 9.752 1.00 4.61 O

ATOM 1549 N ASP A 213 69.053 -17.017 8.058 1.00 4.27 N

ATOM 1550 CA ASP A 213 70.292 -16.576 8.725 1.00 4.07 C

ATOM 1551 CB ASP A 213 70.296 -15.064 9.031 1.00 4.05 C

ATOM 1552 CG ASP A 213 69.934 -14.217 7.826 1.00 4.02 C

ATOM 1553 ODl ASP A 213 70.529 -14.422 6.747 1.00 3.22 O

ATOM 1554 OD2 ASP A 213 69.052 -13.339 7.969 1.00 4.10 O W2025-7029WO / AM102903-PCT

ATOM 1555 C ASP A 213 70.534 -17.370 10.004 1.00 4.12 C

ATOM 1556 O ASP A 213 71.087 -16.849 10.981 1.00 3.97 O

ATOM 1557 N LEU A 214 70.112 -18.632 9.995 1.00 4.40 N

ATOM 1558 CA LEU A 214 70.240 -19.475 11.176 1.00 4.54 C

ATOM 1559 CB LEU A 214 69.300 -20.681 11.092 1.00 4.77 C

ATOM 1560 CG LEU A 214 67.808 -20.298 11.064 1.00 4.61 C

ATOM 1561 CDl LEU A 214 66.902 -21.516 10.889 1.00 5.17 C

ATOM 1562 CD2 LEU A 214 67.404 -19.511 12.307 1.00 4.97 C

ATOM 1563 C LEU A 214 71.696 -19.873 11.408 1.00 4.87 C

ATOM 1564 O LEU A 214 72.080 -20.195 12.529 1.00 4.68 O

ATOM 1565 N HIS A 215 72.490 -19.816 10.336 1.00 5.02 N

ATOM 1566 CA HIS A 215 73.949 -19.964 10.389 1.00 5.09 C

ATOM 1567 CB HIS A 215 74.386 -21.391 10.033 1.00 5.02 C

ATOM 1568 CG HIS A 215 73.944 -22.433 11.013 1.00 4.82 C

ATOM 1569 NDl HIS A 215 74.556 -22.616 12.236 1.00 5.13 N

ATOM 1570 CEl HIS A 215 73.957 -23.601 12.881 1.00 4.60 C

ATOM 1571 NE2 HIS A 215 72.989 -24.073 12.116 1.00 3.18 N

ATOM 1572 CD2 HIS A 215 72.960 -23.360 10.942 1.00 3.57 C

ATOM 1573 C HIS A 215 74.607 -18.990 9.407 1.00 5.19 C

ATOM 1574 O HIS A 215 73.990 -18.572 8.426 1.00 4.85 O

ATOM 1575 N GLY A 216 75.868 -18.654 9.670 1.00 5.52 N

ATOM 1576 CA GLY A 216 76.655 -17.779 8.793 1.00 5.89 C

ATOM 1577 C GLY A 216 78.128 -17.796 9.158 1.00 5.99 C

ATOM 1578 O GLY A 216 78.515 -18.422 10.150 1.00 5.77 O

ATOM 1579 N SER A 217 78.944 -17.102 8.358 1.00 6.25 N

ATOM 1580 CA SER A 217 80.404 -17.062 8.544 1.00 6.09 C

ATOM 1581 CB SER A 217 81.065 -16.303 7.398 1.00 6.17 C

ATOM 1582 OG SER A 217 80.690 -14.929 7.402 1.00 5.56 O

ATOM 1583 C SER A 217 80.812 -16.445 9.883 1.00 6.43 C

ATOM 1584 O SER A 217 81.926 -16.663 10.376 1.00 6.33 O

ATOM 1585 N TRP A 218 79.892 -15.684 10.468 1.00 6.53 N

ATOM 1586 CA TRP A 218 80.088 -15.079 11.776 1.00 6.76 C

ATOM 1587 CB TRP A 218 78.931 -14.128 12.098 1.00 6.58 C

ATOM 1588 CG TRP A 218 77.555 -14.754 12.077 1.00 5.84 C

ATOM 1589 CDl TRP A 218 76.945 -15.428 13.098 1.00 5.53 C

ATOM 1590 NEl TRP A 218 75.686 -15.827 12.720 1.00 5.30 N

ATOM 1591 CE2 TRP A 218 75.449 -15.402 11.439 1.00 5.18 C

ATOM 1592 CD2 TRP A 218 76.608 -14.720 10.998 1.00 5.84 C

ATOM 1593 CE3 TRP A 218 76.624 -14.176 9.706 1.00 5.72 C

ATOM 1594 CZ3 TRP A 218 75.495 -14.343 8.896 1.00 6.13 C

ATOM 1595 CH2 TRP A 218 74.361 -15.035 9.365 1.00 5.89 C

ATOM 1596 CZ2 TRP A 218 74.319 -15.568 10.629 1.00 6.17 C

ATOM 1597 C TRP A 218 80.279 -16.102 12.894 1.00 7.11 C

ATOM 1598 O TRP A 218 80.768 -15.765 13.978 1.00 7.30 O

ATOM 1599 N GLU A 219 79.917 -17.353 12.614 1.00 7.48 N

ATOM 1600 CA GLU A 219 80.070 -18.454 13.569 1.00 7.69 C

ATOM 1601 CB GLU A 219 78.975 -19.504 13.364 1.00 7.65 C

ATOM 1602 CG GLU A 219 77.585 -18.994 13.716 1.00 8.46 C

ATOM 1603 CD GLU A 219 76.527 -20.070 13.624 1.00 9.46 C

ATOM 1604 OEl GLU A 219 76.427 -20.710 12.554 1.00 9.52 O

ATOM 1605 OE2 GLU A 219 75.799 -20.275 14.624 1.00 10.00 O

ATOM 1606 C GLU A 219 81.445 -19.112 13.514 1.00 7.83 C

ATOM 1607 O GLU A 219 81.858 -19.768 14.473 1.00 7.95 O

ATOM 1608 N GLY A 220 82.151 -18.923 12.400 1.00 7.80 N

ATOM 1609 CA GLY A 220 83.492 -19.480 12.218 1.00 7.89 C

ATOM 1610 C GLY A 220 83.544 -20.899 11.671 1.00 7.93 C

ATOM 1611 O GLY A 220 84.607 -21.520 11.658 1.00 7.91 O

ATOM 1612 N TYR A 221 82.398 -21.407 11.214 1.00 7.83 N

ATOM 1613 CA TYR A 221 82.299 -22.739 10.604 1.00 7.62 C

ATOM 1614 CB TYR A 221 82.224 -23.849 11.669 1.00 7.71 C

ATOM 1615 CG TYR A 221 81.253 -23.560 12.792 1.00 8.54 C

ATOM 1616 CDl TYR A 221 79.873 -23.687 12.601 1.00 9.28 C

ATOM 1617 CEl TYR A 221 78.971 -23.404 13.625 1.00 8.91 C W2025-7029WO / AM102903-PCT

ATOM 1618 CZ TYR A 221 79.456 -23.007 14.861 1.00 9.17 C

ATOM 1619 OH TYR A 221 78.576 -22.739 15.882 1.00 8.84 O

ATOM 1620 CE2 TYR A 221 80.822 -22.877 15.075 1.00 9.20 C

ATOM 1621 CD2 TYR A 221 81.710 -23.150 14.041 1.00 8.36 C

ATOM 1622 C TYR A 221 81.082 -22.805 9.682 1.00 7.21 C

ATOM 1623 O TYR A 221 80.148 -22.015 9.834 1.00 7.14 O

ATOM 1624 N THR A 222 81.088 -23.757 8.748 1.00 6.73 N

ATOM 1625 CA THR A 222 79.988 -23.907 7.790 1.00 6.80 C

ATOM 1626 CB THR A 222 80.288 -24.959 6.694 1.00 6.70 C

ATOM 1627 OGl THR A 222 80.463 -26.243 7.302 1.00 6.46 O

ATOM 1628 CG2 THR A 222 81.535 -24.591 5.892 1.00 6.52 C

ATOM 1629 C THR A 222 78.683 -24.296 8.478 1.00 6.71 C

ATOM 1630 O THR A 222 78.686 -24.995 9.495 1.00 6.81 O

ATOM 1631 N GLY A 223 77.575 -23.834 7.905 1.00 6.47 N

ATOM 1632 CA GLY A 223 76.245 -24.131 8.413 1.00 6.15 C

ATOM 1633 C GLY A 223 75.196 -23.666 7.423 1.00 5.93 C

ATOM 1634 O GLY A 223 75.468 -22.824 6.565 1.00 5.33 O

ATOM 1635 N GLU A 224 73.992 -24.214 7.546 1.00 5.94 N

ATOM 1636 CA GLU A 224 72.916 -23.918 6.605 1.00 5.73 C

ATOM 1637 CB GLU A 224 72.000 -25.131 6.434 1.00 5.95 C

ATOM 1638 CG GLU A 224 72.633 -26.262 5.645 1.00 5.91 C

ATOM 1639 CD GLU A 224 72.644 -26.007 4.145 1.00 6.72 C

ATOM 1640 OEl GLU A 224 72.222 -24.914 3.699 1.00 6.49 O

ATOM 1641 OE2 GLU A 224 73.078 -26.915 3.410 1.00 7.55 O

ATOM 1642 C GLU A 224 72.107 -22.687 6.992 1.00 5.66 C

ATOM 1643 O GLU A 224 71.923 -22.396 8.171 1.00 5.87 O

ATOM 1644 N ASN A 225 71.628 -21.977 5.972 1.00 5.42 N

ATOM 1645 CA ASN A 225 70.887 -20.733 6.135 1.00 5.32 C

ATOM 1646 CB ASN A 225 70.781 -20.044 4.772 1.00 4.94 C

ATOM 1647 CG ASN A 225 70.170 -18.667 4.847 1.00 4.77 C

ATOM 1648 ODl ASN A 225 70.400 -17.915 5.795 1.00 3.65 O

ATOM 1649 ND2 ASN A 225 69.405 -18.314 3.820 1.00 3.17 N

ATOM 1650 C ASN A 225 69.501 -20.970 6.747 1.00 5.26 C

ATOM 1651 O ASN A 225 69.094 -20.273 7.675 1.00 5.12 O

ATOM 1652 N SER A 226 68.794 -21.970 6.234 1.00 5.49 N

ATOM 1653 CA SER A 226 67.457 -22.300 6.723 1.00 5.89 C

ATOM 1654 CB SER A 226 66.394 -21.596 5.863 1.00 5.88 C

ATOM 1655 OG SER A 226 65.084 -21.765 6.390 1.00 6.51 O

ATOM 1656 C SER A 226 67.250 -23.821 6.734 1.00 6.03 C

ATOM 1657 O SER A 226 66.433 -24.348 5.969 1.00 6.25 O

ATOM 1658 N PRO A 227 67.985 -24.535 7.609 1.00 6.08 N

ATOM 1659 CA PRO A 227 67.809 -25.986 7.664 1.00 6.01 C

ATOM 1660 CB PRO A 227 68.943 -26.447 8.587 1.00 5.74 C

ATOM 1661 CG PRO A 227 69.272 -25.253 9.436 1.00 5.66 C

ATOM 1662 CD PRO A 227 68.969 -24.045 8.600 1.00 5.78 C

ATOM 1663 C PRO A 227 66.453 -26.330 8.272 1.00 6.43 C

ATOM 1664 O PRO A 227 66.022 -25.672 9.226 1.00 6.04 O

ATOM 1665 N LEU A 228 65.779 -27.336 7.715 1.00 6.75 N

ATOM 1666 CA LEU A 228 64.465 -27.731 8.229 1.00 7.23 C

ATOM 1667 CB LEU A 228 63.719 -28.671 7.260 1.00 7.13 C

ATOM 1668 CG LEU A 228 62.365 -29.252 7.728 1.00 7.07 C

ATOM 1669 CDl LEU A 228 61.404 -28.174 8.232 1.00 6.65 C

ATOM 1670 CD2 LEU A 228 61.707 -30.086 6.629 1.00 6.98 C

ATOM 1671 C LEU A 228 64.588 -28.356 9.613 1.00 7.47 C

ATOM 1672 O LEU A 228 63.825 -28.018 10.518 1.00 6.86 O

ATOM 1673 N TYR A 229 65.563 -29.251 9.767 1.00 8.17 N

ATOM 1674 CA TYR A 229 65.788 -29.961 11.023 1.00 8.55 C

ATOM 1675 CB TYR A 229 65.596 -31.471 10.836 1.00 9.04 C

ATOM 1676 CG TYR A 229 64.265 -31.883 10.258 1.00 9.69 C

ATOM 1677 CDl TYR A 229 63.073 -31.641 10.949 1.00 10.22 C

ATOM 1678 CEl TYR A 229 61.852 -32.031 10.425 1.00 9.25 C

ATOM 1679 CZ TYR A 229 61.812 -32.677 9.203 1.00 9.95 C

ATOM 1680 OH TYR A 229 60.602 -33.066 8.678 1.00 10.22 O W2025-7029WO / AM102903-PCT

ATOM 1681 CE2 TYR A 229 62.979 -32.940 8.503 1.00 10.32 C

ATOM 1682 CD2 TYR A 229 64.196 -32.544 9.035 1.00 10.43 C

ATOM 1683 C TYR A 229 67.202 -29.705 11.523 1.00 8.71 C

ATOM 1684 O TYR A 229 68.044 -29.179 10.791 1.00 8.08 O

ATOM 1685 N LYS A 230 67.456 -30.087 12.771 1.00 9.01 N

ATOM 1686 CA LYS A 230 68.800 -30.021 13.332 1.00 9.98 C

ATOM 1687 CB LYS A 230 68.785 -30.305 14.839 1.00 9.99 C

ATOM 1688 CG LYS A 230 68.336 -31.715 15.223 1.00 11.84 C

ATOM 1689 CD LYS A 230 68.756 -32.058 16.641 1.00 14.86 C

ATOM 1690 CE LYS A 230 68.513 -33.539 16.937 1.00 17.69 C

ATOM 1691 NZ LYS A 230 69.390 -34.026 18.042 1.00 19.62 N

ATOM 1692 C LYS A 230 69.750 -30.982 12.611 1.00 10.05 C

ATOM 1693 O LYS A 230 69.316 -31.958 11.996 1.00 9.80 O

ATOM 1694 N TYR A 231 71.040 -30.667 12.664 1.00 10.56 N

ATOM 1695 CA TYR A 231 72.088 -31.569 12.210 1.00 11.33 C

ATOM 1696 CB TYR A 231 73.357 -30.773 11.880 1.00 11.15 C

ATOM 1697 CG TYR A 231 74.393 -31.547 11.100 1.00 10.99 C

ATOM 1698 CDl TYR A 231 74.211 -31.836 9.748 1.00 10.04 C

ATOM 1699 CEl TYR A 231 75.161 -32.554 9.035 1.00 10.64 C

ATOM 1700 CZ TYR A 231 76.315 -32.980 9.674 1.00 10.70 C

ATOM 1701 OH TYR A 231 77.272 -33.688 8.984 1.00 11.67 O

ATOM 1702 CE2 TYR A 231 76.520 -32.703 11.012 1.00 11.64 C

ATOM 1703 CD2 TYR A 231 75.561 -31.989 11.716 1.00 11.05 C

ATOM 1704 C TYR A 231 72.326 -32.564 13.349 1.00 12.11 C

ATOM 1705 O TYR A 231 72.246 -32.180 14.517 1.00 11.71 O

ATOM 1706 N PRO A 232 72.582 -33.850 13.024 1.00 12.95 N

ATOM 1707 CA PRO A 232 72.680 -34.900 14.046 1.00 13.74 C

ATOM 1708 CB PRO A 232 73.233 -36.088 13.257 1.00 13.83 C

ATOM 1709 CG PRO A 232 72.681 -35.894 11.901 1.00 13.39 C

ATOM 1710 CD PRO A 232 72.763 -34.411 11.672 1.00 13.07 C

ATOM 1711 C PRO A 232 73.587 -34.577 15.239 1.00 14.63 C

ATOM 1712 O PRO A 232 73.332 -35.058 16.349 1.00 14.77 O

ATOM 1713 N THR A 233 74.615 -33.758 15.010 1.00 15.28 N

ATOM 1714 CA THR A 233 75.562 -33.380 16.060 1.00 16.38 C

ATOM 1715 CB THR A 233 77.020 -33.248 15.518 1.00 16.42 C

ATOM 1716 OGl THR A 233 77.087 -32.199 14.545 1.00 16.82 O

ATOM 1717 CG2 THR A 233 77.490 -34.558 14.888 1.00 16.56 C

ATOM 1718 C THR A 233 75.177 -32.099 16.807 1.00 16.71 C

ATOM 1719 O THR A 233 75.873 -31.702 17.748 1.00 16.87 O

ATOM 1720 N ASP A 234 74.083 -31.453 16.393 1.00 17.15 N

ATOM 1721 CA ASP A 234 73.589 -30.248 17.077 1.00 17.55 C

ATOM 1722 CB ASP A 234 72.427 -29.589 16.312 1.00 17.35 C

ATOM 1723 CG ASP A 234 72.868 -28.871 15.030 1.00 17.21 C

ATOM 1724 ODl ASP A 234 71.974 -28.427 14.275 1.00 15.01 O

ATOM 1725 OD2 ASP A 234 74.085 -28.738 14.766 1.00 16.89 O

ATOM 1726 C ASP A 234 73.135 -30.597 18.497 1.00 17.88 C

ATOM 1727 O ASP A 234 72.202 -31.385 18.685 1.00 18.16 O

ATOM 1728 N THR A 235 73.816 -30.020 19.486 1.00 18.22 N

ATOM 1729 CA THR A 235 73.443 -30.169 20.895 1.00 18.72 C

ATOM 1730 CB THR A 235 74.529 -30.923 21.715 1.00 18.84 C

ATOM 1731 OGl THR A 235 75.787 -30.240 21.605 1.00 19.40 O

ATOM 1732 CG2 THR A 235 74.686 -32.361 21.225 1.00 19.66 C

ATOM 1733 C THR A 235 73.203 -28.795 21.517 1.00 18.62 C

ATOM 1734 O THR A 235 73.612 -27.774 20.955 1.00 18.46 O

ATOM 1735 N GLY A 236 72.540 -28.772 22.672 1.00 18.72 N

ATOM 1736 CA GLY A 236 72.314 -27.524 23.406 1.00 18.82 C

ATOM 1737 C GLY A 236 71.532 -26.497 22.605 1.00 18.69 C

ATOM 1738 O GLY A 236 70.537 -26.834 21.967 1.00 18.84 O

ATOM 1739 N SER A 237 71.989 -25.247 22.627 1.00 18.48 N

ATOM 1740 CA SER A 237 71.277 -24.159 21.947 1.00 18.27 C

ATOM 1741 CB SER A 237 71.721 -22.789 22.473 1.00 18.36 C

ATOM 1742 OG SER A 237 73.111 -22.588 22.283 1.00 19.28 O

ATOM 1743 C SER A 237 71.405 -24.228 20.422 1.00 17.77 C W2025-7029WO / AM102903-PCT

ATOM 1744 O SER A 237 70.586 -23.652 19.704 1.00 17.96 O

ATOM 1745 N ASN A 238 72.423 -24.940 19.935 1.00 17.01 N

ATOM 1746 CA ASN A 238 72.578 -25.184 18.500 1.00 16.25 C

ATOM 1747 CB ASN A 238 73.906 -25.879 18.197 1.00 16.46 C

ATOM 1748 CG ASN A 238 75.106 -24.983 18.428 1.00 17.01 C

ATOM 1749 ODl ASN A 238 75.060 -23.772 18.185 1.00 16.52 O

ATOM 1750 ND2 ASN A 238 76.202 -25.581 18.889 1.00 16.75 N

ATOM 1751 C ASN A 238 71.436 -26.021 17.936 1.00 15.61 C

ATOM 1752 O ASN A 238 71.146 -25.960 16.740 1.00 15.15 O

ATOM 1753 N ALA A 239 70.791 -26.794 18.809 1.00 14.86 N

ATOM 1754 CA ALA A 239 69.677 -27.649 18.420 1.00 14.15 C

ATOM 1755 CB ALA A 239 69.413 -28.694 19.495 1.00 14.49 C

ATOM 1756 C ALA A 239 68.408 -26.849 18.125 1.00 13.61 C

ATOM 1757 O ALA A 239 67.425 -27.397 17.636 1.00 13.51 O

ATOM 1758 N TYR A 240 68.440 -25.552 18.422 1.00 13.24 N

ATOM 1759 CA TYR A 240 67.300 -24.668 18.182 1.00 12.45 C

ATOM 1760 CB TYR A 240 67.212 -23.588 19.267 1.00 13.01 C

ATOM 1761 CG TYR A 240 67.258 -24.068 20.707 1.00 13.64 C

ATOM 1762 CDl TYR A 240 66.837 -25.351 21.063 1.00 14.04 C

ATOM 1763 CEl TYR A 240 66.873 -25.781 22.389 1.00 14.53 C

ATOM 1764 CZ TYR A 240 67.324 -24.917 23.374 1.00 14.54 C

ATOM 1765 OH TYR A 240 67.358 -25.334 24.688 1.00 15.26 O

ATOM 1766 CE2 TYR A 240 67.732 -23.634 23.051 1.00 14.89 C

ATOM 1767 CD2 TYR A 240 67.698 -23.216 21.722 1.00 13.95 C

ATOM 1768 C TYR A 240 67.372 -23.995 16.808 1.00 11.74 C

ATOM 1769 O TYR A 240 66.424 -23.331 16.385 1.00 11.62 O

ATOM 1770 N LEU A 241 68.495 -24.176 16.115 1.00 10.48 N

ATOM 1771 CA LEU A 241 68.769 -23.445 14.877 1.00 9.62 C

ATOM 1772 CB LEU A 241 70.270 -23.123 14.769 1.00 9.52 C

ATOM 1773 CG LEU A 241 70.840 -22.208 15.867 1.00 9.55 C

ATOM 1774 CDl LEU A 241 72.369 -22.212 15.832 1.00 9.39 C

ATOM 1775 CD2 LEU A 241 70.297 -20.793 15.756 1.00 7.85 C

ATOM 1776 C LEU A 241 68.243 -24.143 13.616 1.00 9.03 C

ATOM 1777 O LEU A 241 69.000 -24.461 12.692 1.00 8.68 O

ATOM 1778 N ASN A 242 66.931 -24.365 13.590 1.00 8.23 N

ATOM 1779 CA ASN A 242 66.259 -25.004 12.461 1.00 7.71 C

ATOM 1780 CB ASN A 242 66.369 -26.537 12.545 1.00 7.88 C

ATOM 1781 CG ASN A 242 65.880 -27.088 13.876 1.00 8.15 C

ATOM 1782 ODl ASN A 242 64.719 -27.459 14.011 1.00 8.05 O

ATOM 1783 ND2 ASN A 242 66.764 -27.120 14.871 1.00 9.01 N

ATOM 1784 C ASN A 242 64.799 -24.591 12.423 1.00 7.56 C

ATOM 1785 O ASN A 242 64.227 -24.260 13.462 1.00 6.93 O

ATOM 1786 N VAL A 243 64.209 -24.618 11.227 1.00 7.30 N

ATOM 1787 CA VAL A 243 62.823 -24.197 11.008 1.00 7.48 C

ATOM 1788 CB VAL A 243 62.394 -24.357 9.517 1.00 7.42 C

ATOM 1789 CGl VAL A 243 60.931 -23.965 9.321 1.00 6.74 C

ATOM 1790 CG2 VAL A 243 63.288 -23.529 8.599 1.00 6.72 C

ATOM 1791 C VAL A 243 61.848 -24.951 11.913 1.00 7.90 C

ATOM 1792 O VAL A 243 60.975 -24.340 12.532 1.00 7.95 O

ATOM 1793 N ASP A 244 62.011 -26.273 11.976 1.00 8.41 N

ATOM 1794 CA ASP A 244 61.160 -27.154 12.783 1.00 8.87 C

ATOM 1795 CB ASP A 244 61.664 -28.608 12.688 1.00 9.31 C

ATOM 1796 CG ASP A 244 60.989 -29.563 13.686 1.00 11.11 C

ATOM 1797 ODl ASP A 244 59.798 -29.404 14.009 1.00 11.48 O

ATOM 1798 OD2 ASP A 244 61.669 -30.516 14.126 1.00 14.53 O

ATOM 1799 C ASP A 244 61.047 -26.675 14.233 1.00 8.75 C

ATOM 1800 O ASP A 244 59.930 -26.482 14.729 1.00 8.76 O

ATOM 1801 N TYR A 245 62.188 -26.456 14.894 1.00 8.39 N

ATOM 1802 CA TYR A 245 62.183 -26.048 16.301 1.00 8.56 C

ATOM 1803 CB TYR A 245 63.586 -26.077 16.925 1.00 8.89 C

ATOM 1804 CG TYR A 245 63.553 -25.855 18.427 1.00 9.97 C

ATOM 1805 CDl TYR A 245 63.480 -26.938 19.307 1.00 10.47 C

ATOM 1806 CEl TYR A 245 63.433 -26.746 20.684 1.00 10.20 C W2025-7029WO / AM102903-PCT

ATOM 1807 CZ TYR A 245 63.446 -25.465 21.193 1.00 10.21 C

ATOM 1808 OH TYR A 245 63.392 -25.284 22.548 1.00 10.79 O

ATOM 1809 CE2 TYR A 245 63.512 -24.368 20.351 1.00 10.41 C

ATOM 1810 CD2 TYR A 245 63.565 -24.566 18.971 1.00 10.19 C

ATOM 1811 C TYR A 245 61.575 -24.666 16.497 1.00 8.03 C

ATOM 1812 O TYR A 245 60.750 -24.470 17.386 1.00 7.82 O

ATOM 1813 N VAL A 246 61.998 -23.713 15.670 1.00 7.80 N

ATOM 1814 CA VAL A 246 61.574 -22.315 15.814 1.00 7.37 C

ATOM 1815 CB VAL A 246 62.311 -21.395 14.820 1.00 7.33 C

ATOM 1816 CGl VAL A 246 61.777 -19.967 14.893 1.00 7.68 C

ATOM 1817 CG2 VAL A 246 63.810 -21.417 15.083 1.00 7.53 C

ATOM 1818 C VAL A 246 60.061 -22.174 15.652 1.00 7.16 C

ATOM 1819 O VAL A 246 59.402 -21.569 16.496 1.00 6.75 O

ATOM 1820 N MET A 247 59.520 -22.747 14.576 1.00 7.12 N

ATOM 1821 CA MET A 247 58.086 -22.642 14.296 1.00 7.13 C

ATOM 1822 CB MET A 247 57.736 -23.236 12.932 1.00 7.07 C

ATOM 1823 CG MET A 247 58.342 -22.492 11.724 1.00 6.91 C

ATOM 1824 SD MET A 247 58.110 -20.697 11.696 1.00 6.70

ATOM 1825 CE MET A 247 56.319 -20.562 11.698 1.00 6.26 C

ATOM 1826 C MET A 247 57.259 -23.289 15.397 1.00 7.40 C

ATOM 1827 O MET A 247 56.223 -22.762 15.794 1.00 7.48 O

ATOM 1828 N ASN A 248 57.743 -24.417 15.908 1.00 7.45 N

ATOM 1829 CA ASN A 248 57.082 -25.096 17.012 1.00 7.84 C

ATOM 1830 CB ASN A 248 57.560 -26.540 17.132 1.00 7.85 C

ATOM 1831 CG ASN A 248 56.863 -27.454 16.153 1.00 8.50 C

ATOM 1832 ODl ASN A 248 55.650 -27.661 16.241 1.00 9.21 O

ATOM 1833 ND2 ASN A 248 57.621 -28.005 15.208 1.00 7.83 N

ATOM 1834 C ASN A 248 57.199 -24.357 18.337 1.00 7.63 C

ATOM 1835 O ASN A 248 56.289 -24.428 19.154 1.00 7.73 O

ATOM 1836 N TYR A 249 58.294 -23.625 18.532 1.00 7.58 N

ATOM 1837 CA TYR A 249 58.418 -22.746 19.699 1.00 7.84 C

ATOM 1838 CB TYR A 249 59.805 -22.091 19.797 1.00 7.86 C

ATOM 1839 CG TYR A 249 59.993 -21.359 21.106 1.00 8.30 C

ATOM 1840 CDl TYR A 249 60.589 -21.990 22.196 1.00 8.31 C

ATOM 1841 CEl TYR A 249 60.739 -21.340 23.405 1.00 8.35 C

ATOM 1842 CZ TYR A 249 60.285 -20.040 23.545 1.00 8.36 C

ATOM 1843 OH TYR A 249 60.441 -19.396 24.749 1.00 9.26 O

ATOM 1844 CE2 TYR A 249 59.684 -19.388 22.488 1.00 8.43 C

ATOM 1845 CD2 TYR A 249 59.537 -20.047 21.273 1.00 8.22 C

ATOM 1846 C TYR A 249 57.323 -21.669 19.733 1.00 7.60 C

ATOM 1847 O TYR A 249 56.720 -21.418 20.784 1.00 7.22 O

ATOM 1848 N TRP A 250 57.084 -21.034 18.589 1.00 7.49 N

ATOM 1849 CA TRP A 250 56.049 -20.007 18.477 1.00 7.37 C

ATOM 1850 CB TRP A 250 56.119 -19.314 17.111 1.00 7.22 C

ATOM 1851 CG TRP A 250 57.121 -18.204 17.079 1.00 6.45 C

ATOM 1852 CDl TRP A 250 58.420 -18.282 16.667 1.00 6.73 C

ATOM 1853 NEl TRP A 250 59.034 -17.054 16.791 1.00 6.21 N

ATOM 1854 CE2 TRP A 250 58.131 -16.158 17.303 1.00 6.34 C

ATOM 1855 CD2 TRP A 250 56.911 -16.848 17.493 1.00 6.50 C

ATOM 1856 CE3 TRP A 250 55.810 -16.147 18.007 1.00 6.02 C

ATOM 1857 CZ3 TRP A 250 55.962 -14.790 18.306 1.00 6.61 C

ATOM 1858 CH2 TRP A 250 57.189 -14.136 18.102 1.00 6.50 C

ATOM 1859 CZ2 TRP A 250 58.281 -14.802 17.607 1.00 6.70 C

ATOM 1860 C TRP A 250 54.657 -20.588 18.719 1.00 7.79 C

ATOM 1861 O TRP A 250 53.848 -19.989 19.428 1.00 7.51 O

ATOM 1862 N LYS A 251 54.402 -21.756 18.128 1.00 8.04 N

ATOM 1863 CA LYS A 251 53.137 -22.480 18.272 1.00 8.67 C

ATOM 1864 CB LYS A 251 53.204 -23.751 17.423 1.00 9.11 C

ATOM 1865 CG LYS A 251 51.895 -24.303 16.901 1.00 10.90 C

ATOM 1866 CD LYS A 251 52.195 -25.351 15.817 1.00 12.06 C

ATOM 1867 CE LYS A 251 50.956 -26.115 15.378 1.00 14.10 C

ATOM 1868 NZ LYS A 251 51.292 -27.194 14.388 1.00 13.93 N

ATOM 1869 C LYS A 251 52.870 -22.828 19.742 1.00 8.78 C W2025-7029WO / AM102903-PCT

ATOM 1870 O LYS A 251 51.805 -22.502 20.285 1.00 8.54 O

ATOM 1871 N ASP A 252 53.853 -23.464 20.383 1.00 8.89 N

ATOM 1872 CA ASP A 252 53.721 -23.946 21.766 1.00 9.48 C

ATOM 1873 CB ASP A 252 54.928 -24.807 22.162 1.00 9.41 C

ATOM 1874 CG ASP A 252 55.010 -26.107 21.384 1.00 10.24 C

ATOM 1875 ODl ASP A 252 54.034 -26.473 20.695 1.00 10.37 O

ATOM 1876 OD2 ASP A 252 56.072 -26.757 21.458 1.00 11.10 O

ATOM 1877 C ASP A 252 53.556 -22.833 22.790 1.00 9.65 C

ATOM 1878 O ASP A 252 53.033 -23.064 23.884 1.00 10.04 O

ATOM 1879 N ASN A 253 54.006 -21.633 22.436 1.00 9.72 N

ATOM 1880 CA ASN A 253 54.017 -20.515 23.370 1.00 9.99 C

ATOM 1881 CB ASN A 253 55.432 -19.939 23.498 1.00 10.08 C

ATOM 1882 CG ASN A 253 56.377 -20.894 24.195 1.00 10.67 C

ATOM 1883 ODl ASN A 253 56.364 -21.016 25.422 1.00 11.58 O

ATOM 1884 ND2 ASN A 253 57.194 -21.589 23.416 1.00 10.35 N

ATOM 1885 C ASN A 253 52.974 -19.417 23.126 1.00 9.69 C

ATOM 1886 O ASN A 253 53.053 -18.345 23.731 1.00 9.64 O

ATOM 1887 N GLY A 254 52.002 -19.689 22.257 1.00 9.33 N

ATOM 1888 CA GLY A 254 50.806 -18.851 22.178 1.00 9.31 C

ATOM 1889 C GLY A 254 50.383 -18.244 20.852 1.00 9.14 C

ATOM 1890 O GLY A 254 49.417 -17.479 20.815 1.00 8.99 O

ATOM 1891 N ALA A 255 51.092 -18.568 19.773 1.00 8.62 N

ATOM 1892 CA ALA A 255 50.763 -18.036 18.449 1.00 8.65 C

ATOM 1893 CB ALA A 255 52.037 -17.623 17.715 1.00 8.23 C

ATOM 1894 C ALA A 255 49.955 -19.043 17.613 1.00 8.50 C

ATOM 1895 O ALA A 255 50.413 -20.159 17.387 1.00 8.43 O

ATOM 1896 N PRO A 256 48.741 -18.656 17.164 1.00 8.64 N

ATOM 1897 CA PRO A 256 47.895 -19.557 16.377 1.00 8.62 C

ATOM 1898 CB PRO A 256 46.670 -18.695 16.059 1.00 8.76 C

ATOM 1899 CG PRO A 256 46.635 -17.690 17.158 1.00 8.99 C

ATOM 1900 CD PRO A 256 48.075 -17.362 17.390 1.00 8.72 C

ATOM 1901 C PRO A 256 48.567 -20.008 15.091 1.00 8.66 C

ATOM 1902 O PRO A 256 49.101 -19.180 14.350 1.00 8.53 O

ATOM 1903 N ALA A 257 48.529 -21.316 14.838 1.00 8.78 N

ATOM 1904 CA ALA A 257 49.189 -21.926 13.680 1.00 8.86 C

ATOM 1905 CB ALA A 257 48.836 -23.408 13.584 1.00 8.66 C

ATOM 1906 C ALA A 257 48.847 -21.207 12.381 1.00 8.76 C

ATOM 1907 O ALA A 257 49.724 -20.952 11.555 1.00 9.13 O

ATOM 1908 N GLU A 258 47.571 -20.864 12.223 1.00 8.75 N

ATOM 1909 CA GLU A 258 47.075 -20.205 11.013 1.00 8.61 C

ATOM 1910 CB GLU A 258 45.541 -20.163 11.049 1.00 8.89 C

ATOM 1911 CG GLU A 258 44.858 -19.720 9.761 1.00 11.24 C

ATOM 1912 CD GLU A 258 45.134 -20.630 8.572 1.00 14.09 C

ATOM 1913 OEl GLU A 258 45.455 -21.827 8.765 1.00 15.11 O

ATOM 1914 OE2 GLU A 258 45.020 -20.134 7.430 1.00 16.16 O

ATOM 1915 C GLU A 258 47.666 -18.805 10.788 1.00 7.70 C

ATOM 1916 O GLU A 258 47.753 -18.338 9.648 1.00 7.26 O

ATOM 1917 N LYS A 259 48.066 -18.144 11.872 1.00 6.80 N

ATOM 1918 CA LYS A 259 48.683 -16.813 11.785 1.00 6.33 C

ATOM 1919 CB LYS A 259 48.391 -15.986 13.043 1.00 6.10 C

ATOM 1920 CG LYS A 259 46.938 -15.551 13.204 1.00 6.14 C

ATOM 1921 CD LYS A 259 46.798 -14.560 14.351 1.00 6.24 C

ATOM 1922 CE LYS A 259 45.412 -13.911 14.372 1.00 6.78 C

ATOM 1923 NZ LYS A 259 45.301 -12.863 15.431 1.00 5.53 N

ATOM 1924 C LYS A 259 50.193 -16.886 11.556 1.00 5.98 C

ATOM 1925 O LYS A 259 50.818 -15.886 11.196 1.00 6.29 O

ATOM 1926 N LEU A 260 50.770 -18.064 11.783 1.00 5.71 N

ATOM 1927 CA LEU A 260 52.214 -18.269 11.662 1.00 5.12 C

ATOM 1928 CB LEU A 260 52.688 -19.398 12.590 1.00 4.89 C

ATOM 1929 CG LEU A 260 52.739 -19.059 14.077 1.00 3.86 C

ATOM 1930 CDl LEU A 260 52.951 -20.312 14.935 1.00 3.23 C

ATOM 1931 CD2 LEU A 260 53.825 -18.008 14.338 1.00 3.13 C

ATOM 1932 C LEU A 260 52.638 -18.555 10.228 1.00 5.23 C W2025-7029WO / AM102903-PCT

ATOM 1933 O LEU A 260 52.172 -19.513 9.595 1.00 5.54 O

ATOM 1934 N ILE A 261 53.541 -17.721 9.729 1.00 4.89 N

ATOM 1935 CA ILE A 261 53.990 -17.799 8.354 1.00 4.55 C

ATOM 1936 CB ILE A 261 53.690 -16.470 7.602 1.00 4.34 C

ATOM 1937 CGl ILE A 261 52.223 -16.036 7.789 1.00 4.01 C

ATOM 1938 CDl ILE A 261 51.171 -16.986 7.198 1.00 3.35 C

ATOM 1939 CG2 ILE A 261 54.043 -16.583 6.132 1.00 3.62 C

ATOM 1940 C ILE A 261 55.485 -18.126 8.341 1.00 4.56 C

ATOM 1941 O ILE A 261 56.288 -17.425 8.966 1.00 4.77 O

ATOM 1942 N VAL A 262 55.845 -19.193 7.632 1.00 4.34 N

ATOM 1943 CA VAL A 262 57.215 -19.718 7.642 1.00 4.17 C

ATOM 1944 CB VAL A 262 57.256 -21.238 7.272 1.00 4.02 C

ATOM 1945 CGl VAL A 262 58.681 -21.775 7.309 1.00 3.64 C

ATOM 1946 CG2 VAL A 262 56.370 -22.051 8.203 1.00 3.71 C

ATOM 1947 C VAL A 262 58.119 -18.923 6.699 1.00 4.10 C

ATOM 1948 O VAL A 262 57.766 -18.695 5.550 1.00 3.81 O

ATOM 1949 N GLY A 263 59.293 -18.530 7.189 1.00 4.06 N

ATOM 1950 CA GLY A 263 60.255 -17.775 6.381 1.00 4.43 C

ATOM 1951 C GLY A 263 61.061 -18.626 5.418 1.00 4.27 C

ATOM 1952 O GLY A 263 61.702 -19.596 5.823 1.00 4.64 O

ATOM 1953 N PHE A 264 61.017 -18.259 4.140 1.00 4.51 N

ATOM 1954 CA PHE A 264 61.736 -18.965 3.075 1.00 4.36 C

ATOM 1955 CB PHE A 264 60.759 -19.455 1.987 1.00 4.47 C

ATOM 1956 CG PHE A 264 60.039 -20.732 2.327 1.00 4.50 C

ATOM 1957 CDl PHE A 264 59.015 -20.744 3.271 1.00 5.38 C

ATOM 1958 CEl PHE A 264 58.347 -21.919 3.582 1.00 5.38 C

ATOM 1959 CZ PHE A 264 58.687 -23.103 2.933 1.00 4.78 C

ATOM 1960 CE2 PHE A 264 59.701 -23.101 1.979 1.00 4.86 C

ATOM 1961 CD2 PHE A 264 60.367 -21.919 1.681 1.00 4.77 C

ATOM 1962 C PHE A 264 62.758 -18.027 2.433 1.00 4.17 C

ATOM 1963 O PHE A 264 62.378 -16.993 1.889 1.00 4.55 O

ATOM 1964 N PRO A 265 64.057 -18.378 2.493 1.00 4.12 N

ATOM 1965 CA PRO A 265 65.097 -17.530 1.891 1.00 4.08 C

ATOM 1966 CB PRO A 265 66.303 -17.791 2.791 1.00 3.81 C

ATOM 1967 CG PRO A 265 66.127 -19.229 3.253 1.00 3.68 C

ATOM 1968 CD PRO A 265 64.633 -19.553 3.177 1.00 4.01 C

ATOM 1969 C PRO A 265 65.448 -17.846 0.426 1.00 4.10 C

ATOM 1970 O PRO A 265 65.794 -18.986 0.103 1.00 3.90 O

ATOM 1971 N THR A 266 65.375 -16.832 -0.445 1.00 3.91 N

ATOM 1972 CA THR A 266 65.784 -16.979 -1.853 1.00 4.16 C

ATOM 1973 CB THR A 266 64.866 -16.203 -2.823 1.00 4.23 C

ATOM 1974 OGl THR A 266 64.660 -14.878 -2.330 1.00 4.99 O

ATOM 1975 CG2 THR A 266 63.518 -16.903 -2.986 1.00 4.41 C

ATOM 1976 C THR A 266 67.260 -16.585 -2.081 1.00 4.02 C

ATOM 1977 O THR A 266 67.639 -16.086 -3.146 1.00 3.68 O

ATOM 1978 N TYR A 267 68.079 -16.835 -1.064 1.00 3.98 N

ATOM 1979 CA TYR A 267 69.513 -16.562 -1.101 1.00 4.48 C

ATOM 1980 CB TYR A 267 69.793 -15.138 -0.597 1.00 4.15 C

ATOM 1981 CG TYR A 267 69.475 -14.976 0.875 1.00 5.04 C

ATOM 1982 CDl TYR A 267 70.480 -15.079 1.843 1.00 4.15 C

ATOM 1983 CEl TYR A 267 70.191 -14.953 3.188 1.00 5.15 C

ATOM 1984 CZ TYR A 267 68.880 -14.730 3.589 1.00 5.52 C

ATOM 1985 OH TYR A 267 68.590 -14.603 4.928 1.00 5.02 O

ATOM 1986 CE2 TYR A 267 67.863 -14.629 2.652 1.00 5.87 C

ATOM 1987 CD2 TYR A 267 68.163 -14.757 1.306 1.00 4.75 C

ATOM 1988 C TYR A 267 70.181 -17.565 -0.169 1.00 4.42 C

ATOM 1989 O TYR A 267 69.500 -18.238 0.614 1.00 4.29 O

ATOM 1990 N GLY A 268 71.506 -17.650 -0.237 1.00 4.45 N

ATOM 1991 CA GLY A 268 72.267 -18.416 0.748 1.00 4.65 C

ATOM 1992 C GLY A 268 73.457 -17.651 1.295 1.00 4.76 C

ATOM 1993 O GLY A 268 73.795 -16.575 0.798 1.00 4.80 O

ATOM 1994 N HIS A 269 74.084 -18.206 2.330 1.00 4.88 N

ATOM 1995 CA HIS A 269 75.303 -17.640 2.894 1.00 4.75 C W2025-7029WO / AM102903-PCT

ATOM 1996 CB HIS A 269 75.264 -17.646 4.429 1.00 4.58 C

ATOM 1997 CG HIS A 269 74.393 -16.577 5.013 1.00 4.48 C

ATOM 1998 NDl HIS A 269 74.756 -15.248 5.029 1.00 4.02 N

ATOM 1999 CEl HIS A 269 73.794 -14.538 5.595 1.00 4.53 C

ATOM 2000 NE2 HIS A 269 72.825 -15.360 5.953 1.00 4.04 N

ATOM 2001 CD2 HIS A 269 73.174 -16.642 5.599 1.00 3.10 C

ATOM 2002 C HIS A 269 76.531 -18.394 2.410 1.00 4.90 C

ATOM 2003 O HIS A 269 76.534 -19.628 2.381 1.00 5.00 O

ATOM 2004 N ASN A 270 77.573 -17.650 2.041 1.00 4.89 N

ATOM 2005 CA ASN A 270 78.837 -18.269 1.653 1.00 4.91 C

ATOM 2006 CB ASN A 270 79.238 -17.942 0.195 1.00 5.06 C

ATOM 2007 CG ASN A 270 79.431 -16.457 -0.064 1.00 5.43 C

ATOM 2008 ODl ASN A 270 79.404 -15.642 0.851 1.00 6.60 O

ATOM 2009 ND2 ASN A 270 79.637 -16.102 -1.331 1.00 5.17 N

ATOM 2010 C ASN A 270 79.970 -18.043 2.665 1.00 4.92 C

ATOM 2011 O ASN A 270 79.863 -17.197 3.563 1.00 4.56 O

ATOM 2012 N PHE A 271 81.023 -18.846 2.527 1.00 4.67 N

ATOM 2013 CA PHE A 271 82.074 -18.992 3.535 1.00 4.63 C

ATOM 2014 CB PHE A 271 81.835 -20.246 4.392 1.00 4.45 C

ATOM 2015 CG PHE A 271 80.528 -20.268 5.160 1.00 4.16 C

ATOM 2016 CDl PHE A 271 79.312 -20.486 4.510 1.00 3.82 C

ATOM 2017 CEl PHE A 271 78.109 -20.532 5.224 1.00 3.43 C

ATOM 2018 C Z PHE A 271 78.119 -20.389 6.610 1.00 3.14 C

ATOM 2019 CE2 PHE A 271 79.332 -20.204 7.274 1.00 3.26 C

ATOM 2020 CD2 PHE A 271 80.526 -20.148 6.550 1.00 3.94 C

ATOM 2021 C PHE A 271 83.389 -19.210 2.805 1.00 4.95 C

ATOM 2022 O PHE A 271 83.394 -19.716 1.682 1.00 5.01 O

ATOM 2023 N ILE A 272 84.502 -18.849 3.438 1.00 5.26 N

ATOM 2024 CA ILE A 272 85.812 -19.304 2.970 1.00 5.71 C

ATOM 2025 CB ILE A 272 86.889 -18.181 2.994 1.00 5.62 C

ATOM 2026 CGl ILE A 272 86.470 -17.005 2.103 1.00 5.41 C

ATOM 2027 CDl ILE A 272 86.137 -17.383 0.653 1.00 5.70 C

ATOM 2028 CG2 ILE A 272 88.268 -18.732 2.577 1.00 6.43 C

ATOM 2029 C ILE A 272 86.261 -20.496 3.809 1.00 6.01 C

ATOM 2030 O ILE A 272 86.385 -20.395 5.036 1.00 5.92 O

ATOM 2031 N LEU A 273 86.489 -21.623 3.142 1.00 6.05 N

ATOM 2032 CA LEU A 273 86.940 -22.829 3.821 1.00 6.68 C

ATOM 2033 CB LEU A 273 86.789 -24.059 2.916 1.00 6.26 C

ATOM 2034 CG LEU A 273 85.380 -24.502 2.511 1.00 6.56 C

ATOM 2035 CDl LEU A 273 85.455 -25.657 1.516 1.00 5.16 C

ATOM 2036 CD2 LEU A 273 84.534 -24.886 3.728 1.00 5.47 C

ATOM 2037 C LEU A 273 88.386 -22.672 4.265 1.00 6.94 C

ATOM 2038 O LEU A 273 89.263 -22.374 3.446 1.00 6.97 O

ATOM 2039 N SER A 274 88.621 -22.869 5.563 1.00 7.60 N

ATOM 2040 CA SER A 274 89.976 -22.877 6.133 1.00 8.44 C

ATOM 2041 CB SER A 274 89.917 -22.985 7.661 1.00 8.47 C

ATOM 2042 OG SER A 274 89.386 -21.801 8.231 1.00 8.41 O

ATOM 2043 C SER A 274 90.818 -24.022 5.571 1.00 9.21 C

ATOM 2044 O SER A 274 92.038 -23.884 5.402 1.00 9.12 O

ATOM 2045 N ASN A 275 90.155 -25.146 5.296 1.00 9.96 N

ATOM 2046 CA ASN A 275 90.775 -26.314 4.674 1.00 11.03 C

ATOM 2047 CB ASN A 275 91.048 -27.400 5.728 1.00 11.37 C

ATOM 2048 CG ASN A 275 91.892 -28.554 5.192 1.00 13.37 C

ATOM 2049 ODl ASN A 275 92.304 -28.566 4.026 1.00 15.26 O

ATOM 2050 ND2 ASN A 275 92.155 -29.536 6.053 1.00 15.01 N

ATOM 2051 C ASN A 275 89.875 -26.861 3.562 1.00 11.13 C

ATOM 2052 O ASN A 275 88.863 -27.511 3.853 1.00 10.93 O

ATOM 2053 N PRO A 276 90.239 -26.605 2.285 1.00 11.44 N

ATOM 2054 CA PRO A 276 89.420 -27.015 1.133 1.00 11.82 C

ATOM 2055 CB PRO A 276 90.268 -26.605 -0.085 1.00 11.97 C

ATOM 2056 CG PRO A 276 91.644 -26.345 0.449 1.00 12.14 C

ATOM 2057 CD PRO A 276 91.459 -25.893 1.863 1.00 11.71 C

ATOM 2058 C PRO A 276 89.097 -28.508 1.079 1.00 11.89 C W2025-7029WO / AM102903-PCT

ATOM 2059 O PRO A 276 88.158 -28.903 0.389 1.00 12.05 O

ATOM 2060 N SER A 277 89.856 -29.324 1.808 1.00 12.06 N

ATOM 2061 CA SER A 277 89.604 -30.765 1.845 1.00 12.26 C

ATOM 2062 CB SER A 277 90.897 -31.543 2.113 1.00 12.26 C

ATOM 2063 OG SER A 277 91.287 -31.438 3.465 1.00 14.72 O

ATOM 2064 C SER A 277 88.482 -31.160 2.822 1.00 11.88 C

ATOM 2065 O SER A 277 88.003 -32.298 2.790 1.00 11.71 O

ATOM 2066 N ASN A 278 88.069 -30.218 3.673 1.00 11.69 N

ATOM 2067 CA ASN A 278 86.935 -30.410 4.586 1.00 11.43 C

ATOM 2068 CB ASN A 278 87.333 -30.090 6.036 1.00 11.94 C

ATOM 2069 CG ASN A 278 86.240 -30.450 7.048 1.00 13.26 C

ATOM 2070 ODl ASN A 278 85.203 -31.035 6.703 1.00 15.25 O

ATOM 2071 ND2 ASN A 278 86.473 -30.100 8.309 1.00 14.27 N

ATOM 2072 C ASN A 278 85.751 -29.556 4.145 1.00 11.04 C

ATOM 2073 O ASN A 278 85.775 -28.323 4.274 1.00 10.34 O

ATOM 2074 N THR A 279 84.722 -30.218 3.611 1.00 10.54 N

ATOM 2075 CA THR A 279 83.598 -29.529 2.970 1.00 9.86 C

ATOM 2076 CB THR A 279 83.529 -29.858 1.459 1.00 9.83 C

ATOM 2077 OGl THR A 279 83.333 -31.267 1.283 1.00 9.59 O

ATOM 2078 CG2 THR A 279 84.806 -29.434 0.743 1.00 9.04 C

ATOM 2079 C THR A 279 82.241 -29.860 3.600 1.00 9.89 C

ATOM 2080 O THR A 279 81.193 -29.548 3.029 1.00 9.87 O

ATOM 2081 N GLY A 280 82.261 -30.486 4.774 1.00 9.79 N

ATOM 2082 CA GLY A 280 81.026 -30.864 5.464 1.00 9.77 C

ATOM 2083 C GLY A 280 80.383 -29.726 6.242 1.00 9.61 C

ATOM 2084 O GLY A 280 80.886 -28.596 6.240 1.00 9.74 O

ATOM 2085 N ILE A 281 79.258 -30.032 6.890 1.00 9.00 N

ATOM 2086 CA ILE A 281 78.614 -29.130 7.838 1.00 8.82 C

ATOM 2087 CB ILE A 281 77.183 -29.639 8.216 1.00 8.77 C

ATOM 2088 CGl ILE A 281 76.251 -29.657 6.988 1.00 8.67 C

ATOM 2089 CDl ILE A 281 75.971 -28.292 6.346 1.00 9.31 C

ATOM 2090 CG2 ILE A 281 76.589 -28.857 9.404 1.00 8.53 C

ATOM 2091 C ILE A 281 79.492 -29.040 9.085 1.00 8.75 C

ATOM 2092 O ILE A 281 79.915 -30.065 9.625 1.00 8.88 O

ATOM 2093 N GLY A 282 79.784 -27.816 9.517 1.00 8.52 N

ATOM 2094 CA GLY A 282 80.629 -27.591 10.684 1.00 8.53 C

ATOM 2095 C GLY A 282 82.123 -27.587 10.392 1.00 8.52 C

ATOM 2096 O GLY A 282 82.936 -27.668 11.318 1.00 8.38 O

ATOM 2097 N ALA A 283 82.486 -27.500 9.112 1.00 8.57 N

ATOM 2098 CA ALA A 283 83.889 -27.385 8.696 1.00 8.76 C

ATOM 2099 CB ALA A 283 84.018 -27.662 7.189 1.00 8.72 C

ATOM 2100 C ALA A 283 84.415 -25.988 9.030 1.00 8.98 C

ATOM 2101 O ALA A 283 83.691 -25.009 8.850 1.00 9.04 O

ATOM 2102 N PRO A 284 85.674 -25.882 9.513 1.00 9.18 N

ATOM 2103 CA PRO A 284 86.208 -24.560 9.877 1.00 9.02 C

ATOM 2104 CB PRO A 284 87.647 -24.852 10.333 1.00 8.93 C

ATOM 2105 CG PRO A 284 87.970 -26.219 9.807 1.00 9.36 C

ATOM 2106 CD PRO A 284 86.651 -26.961 9.749 1.00 9.22 C

ATOM 2107 C PRO A 284 86.216 -23.579 8.703 1.00 8.80 C

ATOM 2108 O PRO A 284 86.491 -23.966 7.562 1.00 8.89 O

ATOM 2109 N THR A 285 85.890 -22.323 8.993 1.00 8.57 N

ATOM 2110 CA THR A 285 85.935 -21.261 7.994 1.00 8.25 C

ATOM 2111 CB THR A 285 84.524 -20.764 7.618 1.00 8.04 C

ATOM 2112 OGl THR A 285 83.835 -20.333 8.795 1.00 7.54 O

ATOM 2113 CG2 THR A 285 83.737 -21.884 6.956 1.00 7.63 C

ATOM 2114 C THR A 285 86.780 -20.101 8.493 1.00 8.47 C

ATOM 2115 O THR A 285 86.918 -19.906 9.703 1.00 8.93 O

ATOM 2116 N SER A 286 87.338 -19.339 7.556 1.00 8.62 N

ATOM 2117 CA SER A 286 88.205 -18.206 7.882 1.00 9.11 C

ATOM 2118 CB SER A 286 89.562 -18.345 7.178 1.00 9.11 C

ATOM 2119 OG SER A 286 89.400 -18.610 5.798 1.00 11.33 O

ATOM 2120 C SER A 286 87.565 -16.845 7.596 1.00 8.84 C

ATOM 2121 O SER A 286 88.190 -15.807 7.791 1.00 8.91 O W2025-7029WO / AM102903-PCT

ATOM 2122 N GLY A 287 86.312 -16.849 7.152 1.00 8.80 N

ATOM 2123 CA GLY A 287 85.606 -15.607 6.888 1.00 8.30 C

ATOM 2124 C GLY A 287 84.435 -15.773 5.949 1.00 7.96 C

ATOM 2125 O GLY A 287 84.157 -16.875 5.468 1.00 8.24 O

ATOM 2126 N ALA A 288 83.749 -14.664 5.695 1.00 7.62 N

ATOM 2127 CA ALA A 288 82.644 -14.629 4.749 1.00 7.07 C

ATOM 2128 CB ALA A 288 81.935 -13.275 4.807 1.00 7.15 C

ATOM 2129 C ALA A 288 83.142 -14.894 3.346 1.00 6.78 C

ATOM 2130 O ALA A 288 84.232 -14.449 2.961 1.00 6.37 O

ATOM 2131 N GLY A 289 82.337 -15.617 2.578 1.00 6.39 N

ATOM 2132 CA GLY A 289 82.591 -15.748 1.154 1.00 6.24 C

ATOM 2133 C GLY A 289 82.341 -14.406 0.479 1.00 6.26 C

ATOM 2134 O GLY A 289 81.823 -13.474 1.109 1.00 6.15 O

ATOM 2135 N PRO A 290 82.686 -14.302 -0.812 1.00 6.38 N

ATOM 2136 CA PRO A 290 82.630 -13.011 -1.489 1.00 6.43 C

ATOM 2137 CB PRO A 290 83.449 -13.251 -2.759 1.00 6.30 C

ATOM 2138 CG PRO A 290 83.265 -14.709 -3.051 1.00 6.55 C

ATOM 2139 CD PRO A 290 83.134 -15.387 -1.709 1.00 6.32 C

ATOM 2140 C PRO A 290 81.204 -12.584 -1.844 1.00 6.51 C

ATOM 2141 O PRO A 290 80.347 -13.423 -2.116 1.00 6.72 O

ATOM 2142 N ALA A 291 80.964 -11.278 -1.825 1.00 6.52 N

ATOM 2143 CA ALA A 291 79.732 -10.722 -2.362 1.00 6.75 C

ATOM 2144 CB ALA A 291 79.653 -9.246 -2.043 1.00 6.43 C

ATOM 2145 C ALA A 291 79.703 -10.950 -3.875 1.00 6.90 C

ATOM 2146 O ALA A 291 80.751 -10.898 -4.534 1.00 6.60 O

ATOM 2147 N GLY A 292 78.513 -11.223 -4.416 1.00 6.90 N

ATOM 2148 CA GLY A 292 78.344 -11.412 -5.861 1.00 7.24 C

ATOM 2149 C GLY A 292 78.283 -10.074 -6.584 1.00 7.47 C

ATOM 2150 O GLY A 292 78.143 -9.039 -5.938 1.00 7.37 O

ATOM 2151 N PRO A 293 78.361 -10.081 -7.933 1.00 7.82 N

ATOM 2152 CA PRO A 293 78.422 -8.807 -8.658 1.00 7.92 C

ATOM 2153 CB PRO A 293 78.973 -9.213 -10.034 1.00 8.07 C

ATOM 2154 CG PRO A 293 78.549 -10.619 -10.217 1.00 8.17 C

ATOM 2155 CD PRO A 293 78.374 -11.240 -8.847 1.00 7.86 C

ATOM 2156 C PRO A 293 77.065 -8.112 -8.802 1.00 8.06 C

ATOM 2157 O PRO A 293 77.014 -6.962 -9.234 1.00 8.23 O

ATOM 2158 N TYR A 294 75.986 -8.800 -8.431 1.00 8.12 N

ATOM 2159 CA TYR A 294 74.630 -8.261 -8.567 1.00 8.23 C

ATOM 2160 CB TYR A 294 73.686 -9.323 -9.142 1.00 8.48 C

ATOM 2161 CG TYR A 294 73.911 -9.612 -10.607 1.00 9.04 C

ATOM 2162 CDl TYR A 294 74.599 -10.755 -11.017 1.00 10.22 C

ATOM 2163 CEl TYR A 294 74.807 -11.026 -12.377 1.00 10.73 C

ATOM 2164 CZ TYR A 294 74.318 -10.147 -13.331 1.00 10.26 C

ATOM 2165 OH TYR A 294 74.514 -10.409 -14.668 1.00 10.27 O

ATOM 2166 CE2 TYR A 294 73.634 -9.002 -12.946 1.00 9.52 C

ATOM 2167 CD2 TYR A 294 73.433 -8.743 -11.589 1.00 9.11 C

ATOM 2168 C TYR A 294 74.070 -7.690 -7.262 1.00 8.14 C

ATOM 2169 O TYR A 294 73.713 -6.512 -7.200 1.00 7.61 O

ATOM 2170 N ALA A 295 73.997 -8.525 -6.229 1.00 8.21 N

ATOM 2171 CA ALA A 295 73.487 -8.109 -4.928 1.00 8.55 C

ATOM 2172 CB ALA A 295 72.964 -9.315 -4.148 1.00 8.61 C

ATOM 2173 C ALA A 295 74.548 -7.359 -4.119 1.00 8.88 C

ATOM 2174 O ALA A 295 74.219 -6.512 -3.288 1.00 8.67 O

ATOM 2175 N LYS A 296 75.818 -7.678 -4.372 1.00 9.17 N

ATOM 2176 CA LYS A 296 76.958 -7.056 -3.681 1.00 9.66 C

ATOM 2177 CB LYS A 296 77.231 -5.644 -4.222 1.00 9.69 C

ATOM 2178 CG LYS A 296 77.541 -5.602 -5.723 1.00 10.80 C

ATOM 2179 CD LYS A 296 77.942 -4.204 -6.169 1.00 11.00 C

ATOM 2180 CE LYS A 296 77.799 -4.056 -7.684 1.00 13.26 C

ATOM 2181 NZ LYS A 296 78.915 -4.726 -8.414 1.00 15.16 N

ATOM 2182 C LYS A 296 76.835 -7.053 -2.151 1.00 9.44 C

ATOM 2183 O LYS A 296 77.181 -6.071 -1.489 1.00 9.66 O

ATOM 2184 N GLU A 297 76.345 -8.163 -1.603 1.00 9.23 N W2025-7029WO / AM102903-PCT

ATOM 2185 CA GLU A 297 76.205 -8.323 -0.157 1.00 9.58 C

ATOM 2186 CB GLU A 297 74.772 -8.723 0.221 1.00 9.41 C

ATOM 2187 CG GLU A 297 73.728 -7.672 -0.153 1.00 10.48 C

ATOM 2188 CD GLU A 297 72.292 -8.151 0.032 1.00 10.70 C

ATOM 2189 OEl GLU A 297 72.068 -9.164 0.722 1.00 12.45 O

ATOM 2190 OE2 GLU A 297 71.382 -7.507 -0.522 1.00 13.17 O

ATOM 2191 C GLU A 297 77.197 -9.365 0.324 1.00 9.05 C

ATOM 2192 O GLU A 297 77.192 -10.504 -0.153 1.00 8.95 O

ATOM 2193 N SER A 298 78.056 -8.957 1.258 1.00 8.88 N

ATOM 2194 CA SER A 298 79.118 -9.813 1.773 1.00 8.44 C

ATOM 2195 CB SER A 298 80.019 -9.036 2.736 1.00 8.58 C

ATOM 2196 OG SER A 298 80.978 -9.904 3.323 1.00 9.01 O

ATOM 2197 C SER A 298 78.573 -11.064 2.462 1.00 8.12 C

ATOM 2198 O SER A 298 77.637 -10.994 3.270 1.00 7.74 O

ATOM 2199 N GLY A 299 79.164 -12.205 2.128 1.00 7.65 N

ATOM 2200 CA GLY A 299 78.747 -13.484 2.694 1.00 7.54 C

ATOM 2201 C GLY A 299 77.383 -13.959 2.214 1.00 7.36 C

ATOM 2202 O GLY A 299 76.798 -14.861 2.812 1.00 7.61 O

ATOM 2203 N ILE A 300 76.881 -13.358 1.136 1.00 7.08 N

ATOM 2204 CA ILE A 300 75.564 -13.701 0.594 1.00 6.79 C

ATOM 2205 CB ILE A 300 74.479 -12.681 1.045 1.00 7.04 C

ATOM 2206 CGl ILE A 300 74.139 -12.883 2.525 1.00 7.86 C

ATOM 2207 CDl ILE A 300 73.636 -11.649 3.204 1.00 8.15 C

ATOM 2208 CG2 ILE A 300 73.208 -12.797 0.200 1.00 6.31 C

ATOM 2209 C ILE A 300 75.583 -13.791 -0.929 1.00 6.43 C

ATOM 2210 O ILE A 300 76.185 -12.953 -1.601 1.00 6.45 O

ATOM 2211 N TRP A 301 74.922 -14.816 -1.460 1.00 6.15 N

ATOM 2212 CA TRP A 301 74.594 -14.861 -2.878 1.00 5.86 C

ATOM 2213 CB TRP A 301 75.336 -15.997 -3.593 1.00 5.79 C

ATOM 2214 CG TRP A 301 76.788 -15.725 -3.919 1.00 5.62 C

ATOM 2215 CDl TRP A 301 77.380 -14.505 -4.120 1.00 5.86 C

ATOM 2216 NEl TRP A 301 78.712 -14.668 -4.417 1.00 5.77 N

ATOM 2217 CE2 TRP A 301 79.003 -16.009 -4.430 1.00 5.45 C

ATOM 2218 CD2 TRP A 301 77.812 -16.705 -4.128 1.00 5.59 C

ATOM 2219 CE3 TRP A 301 77.842 -18.107 -4.073 1.00 4.68 C

ATOM 2220 CZ3 TRP A 301 79.044 -18.762 -4.317 1.00 5.63 C

ATOM 2221 CH2 TRP A 301 80.216 -18.041 -4.618 1.00 5.92 C

ATOM 2222 CZ2 TRP A 301 80.215 -16.666 -4.675 1.00 5.11 C

ATOM 2223 C TRP A 301 73.090 -15.040 -3.073 1.00 5.96 C

ATOM 2224 O TRP A 301 72.477 -15.933 -2.470 1.00 5.58 O

ATOM 2225 N ALA A 302 72.503 -14.197 -3.918 1.00 5.78 N

ATOM 2226 CA ALA A 302 71.133 -14.414 -4.402 1.00 6.01 C

ATOM 2227 CB ALA A 302 70.746 -13.334 -5.401 1.00 5.81 C

ATOM 2228 C ALA A 302 71.064 -15.783 -5.065 1.00 5.86 C

ATOM 2229 O ALA A 302 72.089 -16.300 -5.514 1.00 6.10 O

ATOM 2230 N TYR A 303 69.873 -16.371 -5.133 1.00 5.86 N

ATOM 2231 CA TYR A 303 69.720 -17.684 -5.771 1.00 5.98 C

ATOM 2232 CB TYR A 303 68.261 -18.158 -5.758 1.00 6.45 C

ATOM 2233 CG TYR A 303 68.076 -19.539 -6.355 1.00 7.13 C

ATOM 2234 CDl TYR A 303 68.720 -20.658 -5.798 1.00 7.14 C

ATOM 2235 CEl TYR A 303 68.557 -21.925 -6.349 1.00 7.90 C

ATOM 2236 CZ TYR A 303 67.738 -22.087 -7.455 1.00 7.72 C

ATOM 2237 OH TYR A 303 67.568 -23.334 -8.003 1.00 9.01 O

ATOM 2238 CE2 TYR A 303 67.090 -21.000 -8.023 1.00 8.22 C

ATOM 2239 CD2 TYR A 303 67.264 -19.732 -7.472 1.00 7.10 C

ATOM 2240 C TYR A 303 70.271 -17.707 -7.197 1.00 6.02 C

ATOM 2241 O TYR A 303 70.936 -18.665 -7.583 1.00 5.89 O

ATOM 2242 N TYR A 304 70.005 -16.652 -7.970 1.00 5.87 N

ATOM 2243 CA TYR A 304 70.518 -16.584 -9.342 1.00 6.15 C

ATOM 2244 CB TYR A 304 69.822 -15.502 -10.188 1.00 5.95 C

ATOM 2245 CG TYR A 304 69.967 -14.064 -9.727 1.00 6.23 C

ATOM 2246 CDl TYR A 304 69.010 -13.475 -8.898 1.00 5.69 C

ATOM 2247 CEl TYR A 304 69.132 -12.133 -8.488 1.00 6.06 C W2025-7029WO / AM102903-PCT

ATOM 2248 CZ TYR A 304 70.218 -11.382 -8.924 1.00 6.60 C

ATOM 2249 OH TYR A 304 70.351 -10.070 -8.536 1.00 6.56 O

ATOM 2250 CE2 TYR A 304 71.174 -11.947 -9.756 1.00 6.45 C

ATOM 2251 CD2 TYR A 304 71.041 -13.279 -10.157 1.00 6.28 C

ATOM 2252 C TYR A 304 72.051 -16.492 -9.395 1.00 6.15 C

ATOM 2253 O TYR A 304 72.666 -17.015 -10.316 1.00 6.31 O

ATOM 2254 N GLU A 305 72.651 -15.849 -8.393 1.00 6.35 N

ATOM 2255 CA GLU A 305 74.114 -15.831 -8.228 1.00 6.89 C

ATOM 2256 CB GLU A 305 74.536 -14.812 -7.159 1.00 6.89 C

ATOM 2257 CG GLU A 305 74.328 -13.357 -7.589 1.00 6.66 C

ATOM 2258 CD GLU A 305 74.705 -12.341 -6.517 1.00 6.98 C

ATOM 2259 OEl GLU A 305 74.460 -12.599 -5.319 1.00 6.07 O

ATOM 2260 OE2 GLU A 305 75.235 -11.266 -6.880 1.00 5.97 O

ATOM 2261 C GLU A 305 74.673 -17.223 -7.897 1.00 6.89 C

ATOM 2262 O GLU A 305 75.751 -17.588 -8.360 1.00 7.13 O

ATOM 2263 N ILE A 306 73.937 -17.994 -7.100 1.00 7.06 N

ATOM 2264 CA ILE A 306 74.320 -19.383 -6.811 1.00 7.22 C

ATOM 2265 CB ILE A 306 73.482 -20.005 -5.656 1.00 7.37 C

ATOM 2266 CGl ILE A 306 73.736 -19.239 -4.351 1.00 7.46 C

ATOM 2267 CDl ILE A 306 72.720 -19.499 -3.249 1.00 6.92 C

ATOM 2268 CG2 ILE A 306 73.832 -21.483 -5.454 1.00 6.88 C

ATOM 2269 C ILE A 306 74.282 -20.245 -8.080 1.00 7.41 C

ATOM 2270 O ILE A 306 75.170 -21.068 -8.297 1.00 7.29 O

ATOM 2271 N CYS A 307 73.283 -20.024 -8.934 1.00 7.71 N

ATOM 2272 CA CYS A 307 73.186 -20.760 -10.195 1.00 8.28 C

ATOM 2273 CB CYS A 307 71.899 -20.393 -10.931 1.00 8.62 C

ATOM 2274 SG CYS A 307 70.439 -21.027 -10.081 1.00 9.77

ATOM 2275 C CYS A 307 74.425 -20.593 -11.087 1.00 8.20 C

ATOM 2276 O CYS A 307 74.863 -21.544 -11.741 1.00 8.46 O

ATOM 2277 N THR A 308 74.995 -19.391 -11.087 1.00 8.06 N

ATOM 2278 CA THR A 308 76.250 -19.111 -11.788 1.00 8.04 C

ATOM 2279 CB THR A 308 76.602 -17.597 -11.704 1.00 7.97 C

ATOM 2280 OGl THR A 308 75.527 -16.827 -12.256 1.00 8.84 O

ATOM 2281 CG2 THR A 308 77.895 -17.278 -12.461 1.00 8.34 C

ATOM 2282 C THR A 308 77.401 -19.944 -11.213 1.00 7.91 C

ATOM 2283 O THR A 308 78.255 -20.436 -11.957 1.00 7.80 O

ATOM 2284 N PHE A 309 77.412 -20.073 -9.885 1.00 7.77 N

ATOM 2285 CA PHE A 309 78.403 -20.845 -9.137 1.00 7.89 C

ATOM 2286 CB PHE A 309 78.138 -20.657 -7.632 1.00 7.71 C

ATOM 2287 CG PHE A 309 79.146 -21.317 -6.711 1.00 7.21 C

ATOM 2288 CDl PHE A 309 80.492 -20.946 -6.726 1.00 6.49 C

ATOM 2289 CEl PHE A 309 81.407 -21.531 -5.845 1.00 6.25 C

ATOM 2290 CZ PHE A 309 80.974 -22.496 -4.933 1.00 7.36 C

ATOM 2291 CE2 PHE A 309 79.623 -22.861 -4.895 1.00 6.56 C

ATOM 2292 CD2 PHE A 309 78.722 -22.264 -5.776 1.00 6.88 C

ATOM 2293 C PHE A 309 78.325 -22.314 -9.559 1.00 8.35 C

ATOM 2294 O PHE A 309 79.351 -22.953 -9.796 1.00 8.17 O

ATOM 2295 N LEU A 310 77.101 -22.823 -9.696 1.00 8.78 N

ATOM 2296 CA LEU A 310 76.869 -24.196 -10.155 1.00 9.77 C

ATOM 2297 CB LEU A 310 75.406 -24.605 -9.942 1.00 9.58 C

ATOM 2298 CG LEU A 310 74.840 -24.470 -8.522 1.00 9.39 C

ATOM 2299 CDl LEU A 310 73.336 -24.732 -8.523 1.00 9.17 C

ATOM 2300 CD2 LEU A 310 75.554 -25.387 -7.536 1.00 9.06 C

ATOM 2301 C LEU A 310 77.272 -24.384 -11.620 1.00 10.53 C

ATOM 2302 O LEU A 310 77.861 -25.407 -11.980 1.00 10.54 O

ATOM 2303 N LYS A 311 76.958 -23.387 -12.451 1.00 11.26 N

ATOM 2304 CA LYS A 311 77.327 -23.395 -13.875 1.00 12.28 C

ATOM 2305 CB LYS A 311 76.738 -22.179 -14.585 1.00 12.42 C

ATOM 2306 CG LYS A 311 75.271 -22.307 -14.939 1.00 14.71 C

ATOM 2307 CD LYS A 311 74.719 -20.972 -15.438 1.00 17.66 C

ATOM 2308 CE LYS A 311 73.636 -21.171 -16.488 1.00 18.57 C

ATOM 2309 NZ LYS A 311 73.290 -19.873 -17.154 1.00 20.20 N

ATOM 2310 C LYS A 311 78.845 -23.436 -14.083 1.00 12.30 C W2025-7029WO / AM102903-PCT

ATOM 2311 O LYS A 311 79.328 -23.971 -15.082 1.00 12.50 O

ATOM 2312 N ASN A 312 79.585 -22.870 -13.131 1.00 12.43 N

ATOM 2313 CA ASN A 312 81.048 -22.901 -13.147 1.00 12.62 C

ATOM 2314 CB ASN A 312 81.613 -21.608 -12.548 1.00 12.69 C

ATOM 2315 CG ASN A 312 81.524 -20.444 -13.506 1.00 13.38 C

ATOM 2316 ODl ASN A 312 82.341 -20.316 -14.418 1.00 13.93 O

ATOM 2317 ND2 ASN A 312 80.529 -19.588 -13.309 1.00 13.56 N

ATOM 2318 C ASN A 312 81.665 -24.140 -12.480 1.00 12.43 C

ATOM 2319 O ASN A 312 82.825 -24.119 -12.057 1.00 12.39 O

ATOM 2320 N GLY A 313 80.879 -25.213 -12.388 1.00 12.12 N

ATOM 2321 CA GLY A 313 81.385 -26.525 -11.995 1.00 11.67 C

ATOM 2322 C GLY A 313 81.435 -26.855 -10.513 1.00 11.29 C

ATOM 2323 O GLY A 313 82.053 -27.848 -10.124 1.00 11.53 O

ATOM 2324 N ALA A 314 80.796 -26.043 -9.676 1.00 10.72 N

ATOM 2325 CA ALA A 314 80.797 -26.310 -8.235 1.00 10.40 C

ATOM 2326 CB ALA A 314 80.082 -25.201 -7.479 1.00 10.11 C

ATOM 2327 C ALA A 314 80.166 -27.669 -7.917 1.00 9.93 C

ATOM 2328 O ALA A 314 79.180 -28.055 -8.541 1.00 9.99 O

ATOM 2329 N THR A 315 80.757 -28.390 -6.964 1.00 9.68 N

ATOM 2330 CA THR A 315 80.237 -29.692 -6.516 1.00 9.74 C

ATOM 2331 CB THR A 315 81.296 -30.469 -5.697 1.00 9.99 C

ATOM 2332 OGl THR A 315 82.451 -30.687 -6.511 1.00 9.97 O

ATOM 2333 CG2 THR A 315 80.755 -31.816 -5.220 1.00 8.88 C

ATOM 2334 C THR A 315 78.965 -29.519 -5.682 1.00 9.86 C

ATOM 2335 O THR A 315 78.944 -28.739 -4.728 1.00 9.45 O

ATOM 2336 N GLN A 316 77.909 -30.243 -6.055 1.00 9.93 N

ATOM 2337 CA GLN A 316 76.623 -30.168 -5.361 1.00 10.32 C

ATOM 2338 CB GLN A 316 75.465 -30.308 -6.353 1.00 10.42 C

ATOM 2339 CG GLN A 316 75.280 -29.124 -7.291 1.00 11.33 C

ATOM 2340 CD GLN A 316 74.077 -29.281 -8.208 1.00 11.97 C

ATOM 2341 OEl GLN A 316 74.226 -29.386 -9.425 1.00 15.23 O

ATOM 2342 NE2 GLN A 316 72.880 -29.304 -7.629 1.00 13.63 N

ATOM 2343 C GLN A 316 76.500 -31.228 -4.274 1.00 10.13 C

ATOM 2344 O GLN A 316 76.711 -32.426 -4.522 1.00 10.01 O

ATOM 2345 N GLY A 317 76.167 -30.778 -3.068 1.00 9.73 N

ATOM 2346 CA GLY A 317 75.960 -31.669 -1.937 1.00 9.44 C

ATOM 2347 C GLY A 317 74.549 -31.559 -1.404 1.00 9.30 C

ATOM 2348 O GLY A 317 73.902 -30.519 -1.552 1.00 9.22 O

ATOM 2349 N TRP A 318 74.070 -32.638 -0.788 1.00 9.40 N

ATOM 2350 CA TRP A 318 72.762 -32.636 -0.138 1.00 9.20 C

ATOM 2351 CB TRP A 318 71.808 -33.616 -0.832 1.00 9.21 C

ATOM 2352 CG TRP A 318 70.416 -33.621 -0.259 1.00 9.22 C

ATOM 2353 CDl TRP A 318 69.848 -34.600 0.504 1.00 9.36 C

ATOM 2354 NEl TRP A 318 68.564 -34.247 0.853 1.00 8.80 N

ATOM 2355 CE2 TRP A 318 68.279 -33.020 0.314 1.00 9.38 C

ATOM 2356 CD2 TRP A 318 69.423 -32.594 -0.398 1.00 9.25 C

ATOM 2357 CE3 TRP A 318 69.392 -31.351 -1.047 1.00 9.16 C

ATOM 2358 CZ3 TRP A 318 68.228 -30.582 -0.969 1.00 9.02 C

ATOM 2359 CH2 TRP A 318 67.106 -31.039 -0.257 1.00 9.07 C

ATOM 2360 CZ2 TRP A 318 67.110 -32.248 0.389 1.00 8.82 C

ATOM 2361 C TRP A 318 72.925 -32.956 1.350 1.00 9.21 C

ATOM 2362 O TRP A 318 73.364 -34.050 1.724 1.00 9.14 O

ATOM 2363 N ASP A 319 72.596 -31.974 2.187 1.00 9.12 N

ATOM 2364 CA ASP A 319 72.637 -32.114 3.643 1.00 9.11 C

ATOM 2365 CB ASP A 319 72.832 -30.725 4.273 1.00 9.55 C

ATOM 2366 CG ASP A 319 72.780 -30.724 5.796 1.00 9.79 C

ATOM 2367 ODl ASP A 319 72.834 -29.611 6.357 1.00 9.87 O

ATOM 2368 OD2 ASP A 319 72.687 -31.795 6.435 1.00 10.78 O

ATOM 2369 C ASP A 319 71.335 -32.797 4.087 1.00 C

ATOM 2370 O ASP A 319 70.410 -32.147 4.594 1.00 8.28 O

ATOM 2371 N ALA A 320 71.294 -34.118 3.884 1.00 8.67 N

ATOM 2372 CA ALA A 320 70.085 -34.946 4.060 1.00 8.51 C

ATOM 2373 CB ALA A 320 70.398 -36.426 3.781 1.00 8.34 C W2025-7029WO / AM102903-PCT

ATOM 2374 C ALA A 320 69.341 -34.800 5.398 1.00 8.74 C

ATOM 2375 O ALA A 320 68.118 -34.646 5.393 1.00 8.64 O

ATOM 2376 N PRO A 321 70.062 -34.869 6.543 1.00 8.71 N

ATOM 2377 CA PRO A 321 69.371 -34.707 7.832 1.00 8.88 C

ATOM 2378 CB PRO A 321 70.513 -34.772 8.854 1.00 9.01 C

ATOM 2379 CG PRO A 321 71.602 -35.510 8.176 1.00 8.59 C

ATOM 2380 CD PRO A 321 71.504 -35.132 6.728 1.00 8.78 C

ATOM 2381 C PRO A 321 68.618 -33.377 7.978 1.00 8.85 C

ATOM 2382 O PRO A 321 67.612 -33.319 8.688 1.00 9.12 O

ATOM 2383 N GLN A 322 69.094 -32.331 7.300 1.00 8.49 N

ATOM 2384 CA GLN A 322 68.497 -30.995 7.410 1.00 8.04 C

ATOM 2385 CB GLN A 322 69.583 -29.953 7.672 1.00 7.66 C

ATOM 2386 CG GLN A 322 70.395 -30.262 8.905 1.00 7.13 C

ATOM 2387 CD GLN A 322 71.206 -29.083 9.400 1.00 6.57 C

ATOM 2388 OEl GLN A 322 70.830 -28.424 10.376 1.00 6.08 O

ATOM 2389 NE2 GLN A 322 72.329 -28.814 8.739 1.00 4.18 N

ATOM 2390 C GLN A 322 67.640 -30.605 6.201 1.00 7.82 C

ATOM 2391 O GLN A 322 66.985 -29.553 6.204 1.00 7.66 O

ATOM 2392 N GLU A 323 67.653 -31.464 5.183 1.00 7.59 N

ATOM 2393 CA GLU A 323 66.831 -31.314 3.977 1.00 7.54 C

ATOM 2394 CB GLU A 323 65.327 -31.407 4.316 1.00 8.07 C

ATOM 2395 CG GLU A 323 64.933 -32.652 5.115 1.00 9.87 C

ATOM 2396 CD GLU A 323 64.845 -33.914 4.271 1.00 12.86 C

ATOM 2397 OEl GLU A 323 64.412 -34.951 4.816 1.00 16.13 O

ATOM 2398 OE2 GLU A 323 65.197 -33.884 3.072 1.00 13.05 O

ATOM 2399 C GLU A 323 67.130 -30.046 3.170 1.00 7.09 C

ATOM 2400 O GLU A 323 66.217 -29.423 2.622 1.00 6.97 O

ATOM 2401 N VAL A 324 68.410 -29.685 3.083 1.00 6.25 N

ATOM 2402 CA VAL A 324 68.842 -28.513 2.313 1.00 5.79 C

ATOM 2403 CB VAL A 324 69.062 -27.270 3.213 1.00 5.85 C

ATOM 2404 CGl VAL A 324 67.736 -26.519 3.451 1.00 5.32 C

ATOM 2405 CG2 VAL A 324 69.732 -27.662 4.525 1.00 5.31 C

ATOM 2406 C VAL A 324 70.126 -28.797 1.523 1.00 5.83 C

ATOM 2407 O VAL A 324 70.941 -29.623 1.943 1.00 5.45 O

ATOM 2408 N PRO A 325 70.305 -28.116 0.372 1.00 5.62 N

ATOM 2409 CA PRO A 325 71.512 -28.336 -0.412 1.00 5.39 C

ATOM 2410 CB PRO A 325 71.101 -27.844 -1.796 1.00 5.24 C

ATOM 2411 CG PRO A 325 70.197 -26.685 -1.488 1.00 5.46 C

ATOM 2412 CD PRO A 325 69.407 -27.138 -0.279 1.00 5.38 C

ATOM 2413 C PRO A 325 72.681 -27.496 0.078 1.00 5.32 C

ATOM 2414 O PRO A 325 72.500 -26.558 0.854 1.00 5.07 O

ATOM 2415 N TYR A 326 73.873 -27.848 -0.387 1.00 5.48 N

ATOM 2416 CA TYR A 326 75.037 -26.984 -0.283 1.00 5.54 C

ATOM 2417 CB TYR A 326 75.782 -27.165 1.052 1.00 5.89 C

ATOM 2418 CG TYR A 326 76.441 -28.512 1.287 1.00 6.79 C

ATOM 2419 CDl TYR A 326 77.792 -28.706 0.995 1.00 7.16 C

ATOM 2420 CEl TYR A 326 78.408 -29.930 1.221 1.00 7.21 C

ATOM 2421 CZ TYR A 326 77.676 -30.976 1.762 1.00 7.41 C

ATOM 2422 OH TYR A 326 78.296 -32.181 1.993 1.00 7.37 O

ATOM 2423 CE2 TYR A 326 76.333 -30.809 2.076 1.00 7.48 C

ATOM 2424 CD2 TYR A 326 75.726 -29.579 1.843 1.00 6.66 C

ATOM 2425 C TYR A 326 75.932 -27.221 -1.495 1.00 5.58 C

ATOM 2426 O TYR A 326 75.743 -28.191 -2.241 1.00 4.85 O

ATOM 2427 N ALA A 327 76.873 -26.309 -1.716 1.00 5.45 N

ATOM 2428 CA ALA A 327 77.777 -26.426 -2.852 1.00 5.99 C

ATOM 2429 CB ALA A 327 77.187 -25.743 -4.085 1.00 5.48 C

ATOM 2430 C ALA A 327 79.141 -25.845 -2.513 1.00 6.39 C

ATOM 2431 O ALA A 327 79.256 -24.978 -1.645 1.00 6.20 O

ATOM 2432 N TYR A 328 80.175 -26.327 -3.196 1.00 7.10 N

ATOM 2433 CA TYR A 328 81.524 -25.831 -2.954 1.00 7.67 C

ATOM 2434 CB TYR A 328 82.168 -26.547 -1.752 1.00 8.22 C

ATOM 2435 CG TYR A 328 82.239 -28.060 -1.886 1.00 8.94 C

ATOM 2436 CDl TYR A 328 81.199 -28.873 -1.424 1.00 9.16 C W2025-7029WO / AM102903-PCT

ATOM 2437 CEl TYR A 328 81.262 -30.266 -1.543 1.00 10.04 C

ATOM 2438 CZ TYR A 328 82.375 -30.849 -2.132 1.00 9.84 C

ATOM 2439 OH TYR A 328 82.448 -32.221 -2.264 1.00 11.44 O

ATOM 2440 CE2 TYR A 328 83.417 -30.060 -2.602 1.00 10.48 C

ATOM 2441 CD2 TYR A 328 83.345 -28.672 -2.474 1.00 9.35 C

ATOM 2442 C TYR A 328 82.403 -25.934 -4.194 1.00 7.94 C

ATOM 2443 O TYR A 328 82.227 -26.820 -5.030 1.00 7.82 O

ATOM 2444 N GLN A 329 83.340 -24.998 -4.301 1.00 8.02 N

ATOM 2445 CA GLN A 329 84.353 -25.005 -5.342 1.00 8.46 C

ATOM 2446 CB GLN A 329 83.904 -24.153 -6.528 1.00 8.89 C

ATOM 2447 CG GLN A 329 84.947 -24.011 -7.627 1.00 10.42 C

ATOM 2448 CD GLN A 329 84.907 -25.150 -8.603 1.00 12.86 C

ATOM 2449 OEl GLN A 329 85.720 -26.075 -8.530 1.00 14.86 O

ATOM 2450 NE2 GLN A 329 83.946 -25.107 -9.524 1.00 12.80 N

ATOM 2451 C GLN A 329 85.629 -24.445 -4.740 1.00 8.11 C

ATOM 2452 O GLN A 329 85.675 -23.276 -4.356 1.00 7.91 O

ATOM 2453 N GLY A 330 86.655 -25.288 -4.652 1.00 7.95 N

ATOM 2454 CA GLY A 330 87.925 -24.909 -4.041 1.00 8.13 C

ATOM 2455 C GLY A 330 87.733 -24.511 -2.591 1.00 7.99 C

ATOM 2456 O GLY A 330 87.224 -25.298 -1.792 1.00 8.29 O

ATOM 2457 N ASN A 331 88.104 -23.275 -2.265 1.00 8.00 N

ATOM 2458 CA ASN A 331 87.964 -22.755 -0.909 1.00 7.67 C

ATOM 2459 CB ASN A 331 89.179 -21.883 -0.559 1.00 8.00 C

ATOM 2460 CG ASN A 331 89.258 -20.610 -1.399 1.00 8.20 C

ATOM 2461 ODl ASN A 331 88.672 -20.512 -2.486 1.00 8.01 O

ATOM 2462 ND2 ASN A 331 89.995 -19.631 -0.897 1.00 8.43 N

ATOM 2463 C ASN A 331 86.651 -21.988 -0.642 1.00 7.28 C

ATOM 2464 O ASN A 331 86.507 -21.352 0.404 1.00 6.88 O

ATOM 2465 N VAL A 332 85.703 -22.041 -1.578 1.00 6.74 N

ATOM 2466 CA VAL A 332 84.420 -21.345 -1.401 1.00 6.47 C

ATOM 2467 CB VAL A 332 84.087 -20.361 -2.573 1.00 6.67 C

ATOM 2468 CGl VAL A 332 82.777 -19.638 -2.307 1.00 5.47 C

ATOM 2469 CG2 VAL A 332 85.211 -19.331 -2.778 1.00 6.88 C

ATOM 2470 C VAL A 332 83.287 -22.355 -1.218 1.00 6.46 C

ATOM 2471 O VAL A 332 83.166 -23.295 -2.002 1.00 6.53 O

ATOM 2472 N TRP A 333 82.470 -22.136 -0.185 1.00 6.16 N

ATOM 2473 CA TRP A 333 81.373 -23.027 0.218 1.00 6.19 C

ATOM 2474 CB TRP A 333 81.741 -23.679 1.555 1.00 6.08 C

ATOM 2475 CG TRP A 333 80.899 -24.854 2.032 1.00 5.87 C

ATOM 2476 CDl TRP A 333 81.198 -26.176 1.889 1.00 5.96 C

ATOM 2477 NEl TRP A 333 80.231 -26.954 2.482 1.00 5.85 N

ATOM 2478 CE2 TRP A 333 79.283 -26.140 3.043 1.00 5.77 C

ATOM 2479 CD2 TRP A 333 79.674 -24.802 2.791 1.00 6.22 C

ATOM 2480 CE3 TRP A 333 78.860 -23.758 3.265 1.00 6.23 C

ATOM 2481 CZ3 TRP A 333 77.693 -24.083 3.973 1.00 5.56 C

ATOM 2482 CH2 TRP A 333 77.334 -25.432 4.203 1.00 6.31 C

ATOM 2483 CZ2 TRP A 333 78.113 -26.467 3.746 1.00 5.77 C

ATOM 2484 C TRP A 333 80.119 -22.178 0.397 1.00 6.14 C

ATOM 2485 O TRP A 333 80.196 -21.080 0.943 1.00 6.01 O

ATOM 2486 N VAL A 334 78.970 -22.680 -0.058 1.00 6.18 N

ATOM 2487 CA VAL A 334 77.691 -21.981 0.135 1.00 6.12 C

ATOM 2488 CB VAL A 334 77.241 -21.195 -1.153 1.00 6.30 C

ATOM 2489 CGl VAL A 334 77.085 -22.120 -2.368 1.00 5.86 C

ATOM 2490 CG2 VAL A 334 75.949 -20.398 -0.904 1.00 6.10 C

ATOM 2491 C VAL A 334 76.583 -22.916 0.651 1.00 6.06 C

ATOM 2492 O VAL A 334 76.416 -24.026 0.152 1.00 6.13 O

ATOM 2493 N GLY A 335 75.856 -22.456 1.668 1.00 6.08 N

ATOM 2494 CA GLY A 335 74.652 -23.128 2.159 1.00 5.80 C

ATOM 2495 C GLY A 335 73.429 -22.331 1.734 1.00 5.90 C

ATOM 2496 O GLY A 335 73.374 -21.122 1.954 1.00 5.78 O

ATOM 2497 N TYR A 336 72.451 -23.009 1.131 1.00 5.68 N

ATOM 2498 CA TYR A 336 71.332 -22.333 0.476 1.00 5.78 C

ATOM 2499 CB TYR A 336 71.751 -21.833 -0.916 1.00 5.66 C W2025-7029WO / AM102903-PCT

ATOM 2500 CG TYR A 336 72.039 -22.920 -1.940 1.00 5.55 C

ATOM 2501 CDl TYR A 336 73.218 -23.669 -1.885 1.00 6.26 C

ATOM 2502 CEl TYR A 336 73.485 -24.672 -2.825 1.00 6.01 C

ATOM 2503 CZ TYR A 336 72.574 -24.917 -3.844 1.00 6.15 C

ATOM 2504 OH TYR A 336 72.838 -25.901 -4.781 1.00 5.16 O

ATOM 2505 CE2 TYR A 336 71.404 -24.174 -3.932 1.00 5.58 C

ATOM 2506 CD2 TYR A 336 71.142 -23.181 -2.983 1.00 5.05 C

ATOM 2507 C TYR A 336 70.068 -23.188 0.373 1.00 5.96 C

ATOM 2508 O TYR A 336 69.951 -24.230 1.026 1.00 6.10 O

ATOM 2509 N ASP A 337 69.125 -22.719 -0.441 1.00 6.04 N

ATOM 2510 CA ASP A 337 67.869 -23.406 -0.701 1.00 6.41 C

ATOM 2511 CB ASP A 337 66.700 -22.674 -0.037 1.00 6.16 C

ATOM 2512 CG ASP A 337 66.496 -23.078 1.410 1.00 7.11 C

ATOM 2513 ODl ASP A 337 67.134 -22.475 2.304 1.00 8.99 O

ATOM 2514 OD2 ASP A 337 65.682 -23.988 1.660 1.00 6.20 O

ATOM 2515 C ASP A 337 67.620 -23.501 -2.206 1.00 6.33 C

ATOM 2516 O ASP A 337 67.871 -22.550 -2.946 1.00 6.54 O

ATOM 2517 N ASN A 338 67.133 -24.653 -2.650 1.00 6.49 N

ATOM 2518 CA ASN A 338 66.775 -24.849 -4.051 1.00 6.50 C

ATOM 2519 CB ASN A 338 67.748 -25.828 -4.734 1.00 6.46 C

ATOM 2520 CG ASN A 338 67.784 -27.206 -4.067 1.00 6.35 C

ATOM 2521 ODl ASN A 338 66.989 -27.514 -3.181 1.00 6.95 O

ATOM 2522 ND2 ASN A 338 68.725 -28.037 -4.495 1.00 7.13 N

ATOM 2523 C ASN A 338 65.303 -25.274 -4.200 1.00 6.70 C

ATOM 2524 O ASN A 338 64.534 -25.180 -3.239 1.00 6.48 O

ATOM 2525 N VAL A 339 64.912 -25.720 -5.396 1.00 6.75 N

ATOM 2526 CA VAL A 339 63.535 -26.175 -5.640 1.00 7.32 C

ATOM 2527 CB VAL A 339 63.309 -26.541 -7.136 1.00 7.50 C

ATOM 2528 CGl VAL A 339 61.939 -27.178 -7.357 1.00 7.17 C

ATOM 2529 CG2 VAL A 339 63.472 -25.304 -8.020 1.00 7.25 C

ATOM 2530 C VAL A 339 63.162 -27.347 -4.714 1.00 7.39 C

ATOM 2531 O VAL A 339 62.086 -27.355 -4.105 1.00 7.51 O

ATOM 2532 N LYS A 340 64.074 -28.309 -4.588 1.00 7.84 N

ATOM 2533 CA LYS A 340 63.861 -29.493 -3.751 1.00 8.09 C

ATOM 2534 CB LYS A 340 65.055 -30.451 -3.861 1.00 8.15 C

ATOM 2535 CG LYS A 340 64.876 -31.784 -3.129 1.00 9.06 C

ATOM 2536 CD LYS A 340 66.083 -32.689 -3.369 1.00 9.27 C

ATOM 2537 CE LYS A 340 65.831 -34.112 -2.898 1.00 11.07 C

ATOM 2538 NZ LYS A 340 67.076 -34.919 -2.963 1.00 12.63 N

ATOM 2539 C LYS A 340 63.587 -29.133 -2.288 1.00 7.79 C

ATOM 2540 O LYS A 340 62.603 -29.600 -1.709 1.00 7.38 O

ATOM 2541 N SER A 341 64.443 -28.288 -1.712 1.00 7.77 N

ATOM 2542 CA SER A 341 64.334 -27.914 -0.302 1.00 7.55 C

ATOM 2543 CB SER A 341 65.606 -27.204 0.182 1.00 7.69 C

ATOM 2544 OG SER A 341 65.788 -25.956 -0.466 1.00 7.20 O

ATOM 2545 C SER A 341 63.104 -27.058 -0.026 1.00 7.55 C

ATOM 2546 O SER A 341 62.455 -27.224 1.007 1.00 7.82 O

ATOM 2547 N PHE A 342 62.797 -26.140 -0.942 1.00 7.48 N

ATOM 2548 CA PHE A 342 61.580 -25.329 -0.851 1.00 7.41 C

ATOM 2549 CB PHE A 342 61.511 -24.308 -1.997 1.00 6.96 C

ATOM 2550 CG PHE A 342 61.977 -22.922 -1.621 1.00 6.45 C

ATOM 2551 CDl PHE A 342 63.093 -22.732 -0.818 1.00 6.06 C

ATOM 2552 CEl PHE A 342 63.526 -21.440 -0.476 1.00 5.72 C

ATOM 2553 CZ PHE A 342 62.847 -20.328 -0.962 1.00 5.90 C

ATOM 2554 CE2 PHE A 342 61.736 -20.505 -1.777 1.00 6.51 C

ATOM 2555 CD2 PHE A 342 61.310 -21.800 -2.111 1.00 5.97 C

ATOM 2556 C PHE A 342 60.327 -26.199 -0.856 1.00 7.50 C

ATOM 2557 O PHE A 342 59.415 -25.978 -0.056 1.00 7.19 O

ATOM 2558 N ASP A 343 60.293 -27.183 -1.756 1.00 8.03 N

ATOM 2559 CA ASP A 343 59.164 -28.113 -1.842 1.00 8.56 C

ATOM 2560 CB ASP A 343 59.263 -29.007 -3.081 1.00 9.18 C

ATOM 2561 CG ASP A 343 57.992 -29.819 -3.317 1.00 11.57 C

ATOM 2562 ODl ASP A 343 56.931 -29.215 -3.579 1.00 14.44 O W2025-7029WO / AM102903-PCT

ATOM 2563 OD2 ASP A 343 58.049 -31.064 -3.239 1.00 14.55 O

ATOM 2564 C ASP A 343 59.014 -28.963 -0.578 1.00 8.14 C

ATOM 2565 O ASP A 343 57.900 -29.128 -0.078 1.00 7.99 O

ATOM 2566 N ILE A 344 60.130 -29.484 -0.069 1.00 7.70 N

ATOM 2567 CA ILE A 344 60.139 -30.286 1.161 1.00 8.02 C

ATOM 2568 CB ILE A 344 61.568 -30.834 1.482 1.00 7.92 C

ATOM 2569 CGl ILE A 344 61.952 -31.954 0.507 1.00 8.29 C

ATOM 2570 CDl ILE A 344 63.436 -32.313 0.520 1.00 7.95 C

ATOM 2571 CG2 ILE A 344 61.657 -31.351 2.919 1.00 8.35 C

ATOM 2572 C ILE A 344 59.579 -29.492 2.352 1.00 7.93 C

ATOM 2573 O ILE A 344 58.742 -29.991 3.107 1.00 7.92 O

ATOM 2574 N LYS A 345 60.044 -28.256 2.511 1.00 7.99 N

ATOM 2575 CA LYS A 345 59.592 -27.397 3.600 1.00 7.98 C

ATOM 2576 CB LYS A 345 60.472 -26.162 3.711 1.00 8.14 C

ATOM 2577 CG LYS A 345 61.873 -26.383 4.207 1.00 8.72 C

ATOM 2578 CD LYS A 345 62.657 -25.140 3.825 1.00 10.08 C

ATOM 2579 CE LYS A 345 64.063 -25.169 4.305 1.00 9.21 C

ATOM 2580 NZ LYS A 345 64.639 -23.812 4.135 1.00 7.85 N

ATOM 2581 C LYS A 345 58.142 -26.952 3.412 1.00 7.90 C

ATOM 2582 O LYS A 345 57.412 -26.792 4.394 1.00 7.79 O

ATOM 2583 N ALA A 346 57.736 -26.742 2.157 1.00 7.93 N

ATOM 2584 CA ALA A 346 56.345 -26.407 1.837 1.00 8.10 C

ATOM 2585 CB ALA A 346 56.186 -26.101 0.352 1.00 7.98 C

ATOM 2586 C ALA A 346 55.414 -27.543 2.253 1.00 8.34 C

ATOM 2587 O ALA A 346 54.385 -27.309 2.891 1.00 8.58 O

ATOM 2588 N GLN A 347 55.787 -28.771 1.897 1.00 8.46 N

ATOM 2589 CA GLN A 347 55.030 -29.953 2.302 1.00 8.59 C

ATOM 2590 CB GLN A 347 55.617 -31.235 1.683 1.00 8.74 C

ATOM 2591 CG GLN A 347 55.664 -31.259 0.142 1.00 9.71 C

ATOM 2592 CD GLN A 347 54.313 -30.984 -0.517 1.00 11.90 C

ATOM 2593 OEl GLN A 347 53.258 -31.365 0.001 1.00 13.44 O

ATOM 2594 NE2 GLN A 347 54.345 -30.328 -1.674 1.00 11.72 N

ATOM 2595 C GLN A 347 54.955 -30.065 3.824 1.00 8.31 C

ATOM 2596 O GLN A 347 53.881 -30.318 4.373 1.00 8.37 O

ATOM 2597 N TRP A 348 56.096 -29.862 4.488 1.00 8.02 N

ATOM 2598 CA TRP A 348 56.198 -29.874 5.955 1.00 8.15 C

ATOM 2599 CB TRP A 348 57.641 -29.576 6.386 1.00 8.01 C

ATOM 2600 CG TRP A 348 57.823 -29.516 7.871 1.00 7.82 C

ATOM 2601 CDl TRP A 348 58.047 -30.569 8.712 1.00 7.93 C

ATOM 2602 NEl TRP A 348 58.156 -30.127 10.006 1.00 8.33 N

ATOM 2603 CE2 TRP A 348 57.996 -28.767 10.028 1.00 7.87 C

ATOM 2604 CD2 TRP A 348 57.785 -28.344 8.697 1.00 8.05 C

ATOM 2605 CE3 TRP A 348 57.595 -26.977 8.441 1.00 7.67 C

ATOM 2606 CZ3 TRP A 348 57.619 -26.091 9.512 1.00 8.03 C

ATOM 2607 CH2 TRP A 348 57.834 -26.547 10.827 1.00 7.79 C

ATOM 2608 CZ2 TRP A 348 58.025 -27.874 11.103 1.00 8.33 C

ATOM 2609 C TRP A 348 55.248 -28.876 6.628 1.00 8.26 C

ATOM 2610 O TRP A 348 54.591 -29.195 7.624 1.00 7.88 O

ATOM 2611 N LEU A 349 55.226 -27.665 6.075 1.00 8.57 N

ATOM 2612 CA LEU A 349 54.392 -26.559 6.520 1.00 9.11 C

ATOM 2613 CB LEU A 349 54.643 -25.382 5.571 1.00 9.42 C

ATOM 2614 CG LEU A 349 53.977 -24.015 5.511 1.00 10.23 C

ATOM 2615 CDl LEU A 349 54.807 -23.180 4.547 1.00 9.37 C

ATOM 2616 CD2 LEU A 349 52.517 -24.068 5.062 1.00 10.19 C

ATOM 2617 C LEU A 349 52.924 -26.970 6.508 1.00 8.99 C

ATOM 2618 O LEU A 349 52.184 -26.693 7.465 1.00 9.06 O

ATOM 2619 N LYS A 350 52.512 -27.627 5.423 1.00 8.97 N

ATOM 2620 CA LYS A 350 51.141 -28.119 5.286 1.00 9.31 C

ATOM 2621 CB LYS A 350 50.873 -28.613 3.861 1.00 9.29 C

ATOM 2622 CG LYS A 350 51.012 -27.531 2.795 1.00 9.08 C

ATOM 2623 CD LYS A 350 50.465 -27.974 1.442 1.00 9.92 C

ATOM 2624 CE LYS A 350 51.326 -29.050 0.810 1.00 10.51 C

ATOM 2625 NZ LYS A 350 50.730 -29.578 -0.455 1.00 11.56 N W2025-7029WO / AM102903-PCT

ATOM 2626 C LYS A 350 50.803 -29.204 6.316 1.00 9.31 C

ATOM 2627 O LYS A 350 49.732 -29.169 6.930 1.00 9.12 O

ATOM 2628 N HIS A 351 51.723 -30.148 6.523 1.00 9.18 N

ATOM 2629 CA HIS A 351 51.514 -31.224 7.506 1.00 9.10 C

ATOM 2630 CB HIS A 351 52.669 -32.234 7.497 1.00 9.13 C

ATOM 2631 CG HIS A 351 52.988 -32.786 6.141 1.00 9.34 C

ATOM 2632 NDl HIS A 351 54.265 -33.146 5.770 1.00 9.45 N

ATOM 2633 CEl HIS A 351 54.251 -33.589 4.525 1.00 10.95 C

ATOM 2634 NE2 HIS A 351 53.011 -33.525 4.072 1.00 10.96 N

ATOM 2635 CD2 HIS A 351 52.201 -33.022 5.064 1.00 9.82 C

ATOM 2636 C HIS A 351 51.313 -30.678 8.915 1.00 8.90 C

ATOM 2637 O HIS A 351 50.552 -31.241 9.702 1.00 9.06 O

ATOM 2638 N ASN A 352 51.984 -29.568 9.214 1.00 8.39 N

ATOM 2639 CA ASN A 352 51.907 -28.941 10.527 1.00 8.32 C

ATOM 2640 CB ASN A 352 53.287 -28.431 10.942 1.00 8.01 C

ATOM 2641 CG ASN A 352 54.240 -29.556 11.286 1.00 6.88 C

ATOM 2642 ODl ASN A 352 54.373 -29.934 12.451 1.00 5.89 O

ATOM 2643 ND2 ASN A 352 54.900 -30.105 10.273 1.00 5.74 N

ATOM 2644 C ASN A 352 50.868 -27.820 10.622 1.00 8.56 C

ATOM 2645 O ASN A 352 50.745 -27.175 11.663 1.00 8.54 O

ATOM 2646 N LYS A 353 50.149 -27.593 9.521 1.00 8.56 N

ATOM 2647 CA LYS A 353 49.027 -26.640 9.451 1.00 9.11 C

ATOM 2648 CB LYS A 353 47.843 -27.131 10.291 1.00 9.47 C

ATOM 2649 CG LYS A 353 47.257 -28.435 9.796 1.00 10.66 C

ATOM 2650 CD LYS A 353 46.190 -28.922 10.739 1.00 13.74 C

ATOM 2651 CE LYS A 353 45.572 -30.207 10.242 1.00 15.59 C

ATOM 2652 NZ LYS A 353 44.460 -30.566 11.160 1.00 18.40 N

ATOM 2653 C LYS A 353 49.368 -25.176 9.777 1.00 8.77 C

ATOM 2654 O LYS A 353 48.591 -24.470 10.432 1.00 8.57 O

ATOM 2655 N PHE A 354 50.528 -24.726 9.305 1.00 8.33 N

ATOM 2656 CA PHE A 354 50.886 -23.316 9.391 1.00 7.96 C

ATOM 2657 CB PHE A 354 52.412 -23.131 9.346 1.00 7.95 C

ATOM 2658 CG PHE A 354 53.113 -23.668 10.563 1.00 8.52 C

ATOM 2659 CDl PHE A 354 53.927 -24.795 10.477 1.00 9.09 C

ATOM 2660 CEl PHE A 354 54.567 -25.305 11.615 1.00 8.53 C

ATOM 2661 CZ PHE A 354 54.371 -24.695 12.853 1.00 8.93 C

ATOM 2662 CE2 PHE A 354 53.556 -23.571 12.947 1.00 8.87 C

ATOM 2663 CD2 PHE A 354 52.930 -23.068 11.806 1.00 8.49 C

ATOM 2664 C PHE A 354 50.159 -22.512 8.311 1.00 7.42 C

ATOM 2665 O PHE A 354 49.619 -23.083 7.353 1.00 6.99 O

ATOM 2666 N GLY A 355 50.132 -21.190 8.480 1.00 7.02 N

ATOM 2667 CA GLY A 355 49.320 -20.313 7.631 1.00 6.28 C

ATOM 2668 C GLY A 355 49.826 -20.125 6.220 1.00 6.14 C

ATOM 2669 O GLY A 355 49.091 -19.657 5.342 1.00 6.18 O

ATOM 2670 N GLY A 356 51.088 -20.482 6.000 1.00 5.78 N

ATOM 2671 CA GLY A 356 51.699 -20.356 4.691 1.00 5.76 C

ATOM 2672 C GLY A 356 53.173 -20.022 4.778 1.00 5.71 C

ATOM 2673 O GLY A 356 53.820 -20.269 5.802 1.00 5.59 O

ATOM 2674 N ALA A 357 53.688 -19.446 3.695 1.00 5.69 N

ATOM 2675 CA ALA A 357 55.106 -19.131 3.556 1.00 5.67 C

ATOM 2676 CB ALA A 357 55.691 -19.919 2.408 1.00 5.42 C

ATOM 2677 C ALA A 357 55.295 -17.642 3.304 1.00 5.60 C

ATOM 2678 O ALA A 357 54.432 -16.994 2.704 1.00 5.42 O

ATOM 2679 N MET A 358 56.410 -17.096 3.778 1.00 5.72 N

ATOM 2680 CA MET A 358 56.837 -15.771 3.332 1.00 5.55 C

ATOM 2681 CB MET A 358 56.694 -14.697 4.429 1.00 5.55 C

ATOM 2682 CG MET A 358 57.563 -14.848 5.667 1.00 5.92 C

ATOM 2683 SD MET A 358 59.229 -14.219 5.400 1.00 6.83

ATOM 2684 CE MET A 358 59.745 -13.912 7.093 1.00 5.73 C

ATOM 2685 C MET A 358 58.231 -15.851 2.714 1.00 5.60 C

ATOM 2686 O MET A 358 59.011 -16.752 3.037 1.00 6.38 O

ATOM 2687 N VAL A 359 58.529 -14.937 1.798 1.00 5.07 N

ATOM 2688 CA VAL A 359 59.762 -15.018 1.017 1.00 4.73 C W2025-7029WO / AM102903-PCT

ATOM 2689 CB VAL A 359 59.478 -15.271 -0.494 1.00 4.71 C

ATOM 2690 CGl VAL A 359 60.778 -15.358 -1.280 1.00 4.06 C

ATOM 2691 CG2 VAL A 359 58.643 -16.538 -0.704 1.00 3.90 C

ATOM 2692 C VAL A 359 60.610 -13.752 1.159 1.00 4.85 C

ATOM 2693 O VAL A 359 60.149 -12.647 0.852 1.00 4.57 O

ATOM 2694 N TRP A 360 61.843 -13.939 1.628 1.00 4.89 N

ATOM 2695 CA TRP A 360 62.881 -12.920 1.546 1.00 5.08 C

ATOM 2696 CB TRP A 360 63.482 -12.644 2.933 1.00 5.14 C

ATOM 2697 CG TRP A 360 64.372 -11.438 2.933 1.00 5.30 C

ATOM 2698 CDl TRP A 360 65.712 -11.398 2.650 1.00 4.93 C

ATOM 2699 NEl TRP A 360 66.173 -10.106 2.728 1.00 5.16 N

ATOM 2700 CE2 TRP A 360 65.130 -9.281 3.057 1.00 5.33 C

ATOM 2701 CD2 TRP A 360 63.977 -10.086 3.195 1.00 5.53 C

ATOM 2702 CE3 TRP A 360 62.763 -9.480 3.539 1.00 5.44 C

ATOM 2703 CZ3 TRP A 360 62.736 -8.102 3.730 1.00 5.56 C

ATOM 2704 CH2 TRP A 360 63.902 -7.331 3.589 1.00 5.31 C

ATOM 2705 CZ2 TRP A 360 65.105 -7.903 3.257 1.00 5.19 C

ATOM 2706 C TRP A 360 63.978 -13.359 0.552 1.00 5.14 C

ATOM 2707 O TRP A 360 64.794 -14.215 0.876 1.00 5.02 O

ATOM 2708 N ALA A 361 64.010 -12.795 -0.658 1.00 5.19 N

ATOM 2709 CA ALA A 361 63.073 -11.784 -1.138 1.00 5.06 C

ATOM 2710 CB ALA A 361 63.683 -10.379 -0.987 1.00 4.79 C

ATOM 2711 C ALA A 361 62.750 -12.070 -2.603 1.00 5.20 C

ATOM 2712 O ALA A 361 63.498 -12.784 -3.273 1.00 5.42 O

ATOM 2713 N ILE A 362 61.651 -11.504 -3.103 1.00 5.31 N

ATOM 2714 CA ILE A 362 61.190 -11.754 -4.478 1.00 5.70 C

ATOM 2715 CB ILE A 362 59.828 -11.029 -4.782 1.00 5.78 C

ATOM 2716 CGl ILE A 362 59.219 -11.517 -6.104 1.00 6.13 C

ATOM 2717 CDl ILE A 362 57.724 -11.305 -6.219 1.00 6.15 C

ATOM 2718 CG2 ILE A 362 59.985 -9.497 -4.777 1.00 6.04 C

ATOM 2719 C ILE A 362 62.274 -11.423 -5.523 1.00 5.69 C

ATOM 2720 O ILE A 362 62.439 -12.136 -6.516 1.00 5.60 O

ATOM 2721 N ASP A 363 63.028 -10.360 -5.257 1.00 5.50 N

ATOM 2722 CA ASP A 363 64.079 -9.880 -6.154 1.00 5.70 C

ATOM 2723 CB ASP A 363 64.365 -8.394 -5.877 1.00 5.46 C

ATOM 2724 CG ASP A 363 64.680 -8.113 -4.417 1.00 5.97 C

ATOM 2725 ODl ASP A 363 65.736 -8.573 -3.938 1.00 5.82 O

ATOM 2726 OD2 ASP A 363 63.881 -7.411 -3.754 1.00 5.75 O

ATOM 2727 C ASP A 363 65.373 -10.714 -6.110 1.00 5.60 C

ATOM 2728 O ASP A 363 66.308 -10.456 -6.870 1.00 5.64 O

ATOM 2729 N LEU A 364 65.418 -11.712 -5.229 1.00 5.76 N

ATOM 2730 CA LEU A 364 66.585 -12.595 -5.127 1.00 5.64 C

ATOM 2731 CB LEU A 364 67.014 -12.776 -3.666 1.00 5.37 C

ATOM 2732 CG LEU A 364 67.440 -11.519 -2.896 1.00 4.80 C

ATOM 2733 CDl LEU A 364 67.548 -11.811 -1.401 1.00 4.00 C

ATOM 2734 CD2 LEU A 364 68.747 -10.915 -3.420 1.00 3.53 C

ATOM 2735 C LEU A 364 66.402 -13.943 -5.843 1.00 6.01 C

ATOM 2736 O LEU A 364 67.386 -14.636 -6.135 1.00 5.83 O

ATOM 2737 N ASP A 365 65.150 -14.288 -6.153 1.00 6.30 N

ATOM 2738 CA ASP A 365 64.824 -15.460 -6.978 1.00 6.72 C

ATOM 2739 CB ASP A 365 63.299 -15.684 -6.970 1.00 6.92 C

ATOM 2740 CG ASP A 365 62.885 -17.101 -7.378 1.00 6.81 C

ATOM 2741 ODl ASP A 365 63.741 -17.947 -7.726 1.00 6.30 O

ATOM 2742 OD2 ASP A 365 61.667 -17.369 -7.347 1.00 8.06 O

ATOM 2743 C ASP A 365 65.320 -15.209 -8.408 1.00 7.12 C

ATOM 2744 O ASP A 365 65.627 -14.067 -8.769 1.00 7.11 O

ATOM 2745 N ASP A 366 65.411 -16.263 -9.217 1.00 7.72 N

ATOM 2746 CA ASP A 366 65.800 -16.096 -10.628 1.00 8.45 C

ATOM 2747 CB ASP A 366 66.348 -17.404 -11.219 1.00 8.41 C

ATOM 2748 CG ASP A 366 66.937 -17.228 -12.628 1.00 8.51 C

ATOM 2749 ODl ASP A 366 67.296 -16.095 -13.012 1.00 8.91 O

ATOM 2750 OD2 ASP A 366 67.034 -18.235 -13.354 1.00 7.51 O

ATOM 2751 C ASP A 366 64.610 -15.566 -11.424 1.00 8.59 C W2025-7029WO / AM102903-PCT

ATOM 2752 O ASP A 366 63.942 -16.307 -12.150 1.00 9.18 O

ATOM 2753 N PHE A 367 64.351 -14.268 -11.275 1.00 8.83 N

ATOM 2754 CA PHE A 367 63.153 -13.647 -11.836 1.00 8.70 C

ATOM 2755 CB PHE A 367 62.871 -12.284 -11.183 1.00 8.39 C

ATOM 2756 CG PHE A 367 63.949 -11.251 -11.395 1.00 8.03 C

ATOM 2757 CDl PHE A 367 65.062 -11.197 -10.558 1.00 7.38 C

ATOM 2758 CEl PHE A 367 66.051 -10.229 -10.746 1.00 7.69 C

ATOM 2759 CZ PHE A 367 65.920 -9.293 -11.771 1.00 7.60 C

ATOM 2760 CE2 PHE A 367 64.813 -9.332 -12.607 1.00 7.95 C

ATOM 2761 CD2 PHE A 367 63.829 -10.305 -12.412 1.00 7.67 C

ATOM 2762 C PHE A 367 63.151 -13.564 -13.364 1.00 9.13 C

ATOM 2763 O PHE A 367 62.091 -13.671 -13.989 1.00 9.45 O

ATOM 2764 N THR A 368 64.331 -13.394 -13.960 1.00 9.18 N

ATOM 2765 CA THR A 368 64.464 -13.402 -15.421 1.00 9.33 C

ATOM 2766 CB THR A 368 65.807 -12.793 -15.897 1.00 9.34 C

ATOM 2767 OGl THR A 368 66.888 -13.666 -15.541 1.00 9.20 O

ATOM 2768 CG2 THR A 368 66.032 -11.420 -15.286 1.00 9.79 C

ATOM 2769 C THR A 368 64.361 -14.815 -15.993 1.00 9.32 C

ATOM 2770 O THR A 368 63.953 -14.997 -17.141 1.00 9.13 O

ATOM 2771 N GLY A 369 64.747 -15.802 -15.187 1.00 9.49 N

ATOM 2772 CA GLY A 369 64.841 -17.192 -15.620 1.00 9.84 C

ATOM 2773 C GLY A 369 66.081 -17.496 -16.450 1.00 10.30 C

ATOM 2774 O GLY A 369 66.184 -18.575 -17.032 1.00 10.71 O

ATOM 2775 N THR A 370 67.025 -16.555 -16.509 1.00 10.42 N

ATOM 2776 CA THR A 370 68.209 -16.700 -17.376 1.00 10.37 C

ATOM 2777 CB THR A 370 68.613 -15.358 -18.038 1.00 10.21 C

ATOM 2778 OGl THR A 370 69.010 -14.420 -17.032 1.00 9.32 O

ATOM 2779 CG2 THR A 370 67.456 -14.773 -18.851 1.00 10.18 C

ATOM 2780 C THR A 370 69.437 -17.313 -16.689 1.00 10.82 C

ATOM 2781 O THR A 370 70.408 -17.684 -17.364 1.00 10.71 O

ATOM 2782 N PHE A 371 69.400 -17.423 -15.361 1.00 10.85 N

ATOM 2783 CA PHE A 371 70.552 -17.941 -14.603 1.00 11.32 C

ATOM 2784 CB PHE A 371 70.733 -17.155 -13.295 1.00 11.16 C

ATOM 2785 CG PHE A 371 71.174 -15.728 -13.492 1.00 11.56 C

ATOM 2786 CDl PHE A 371 70.242 -14.723 -13.749 1.00 11.31 C

ATOM 2787 CEl PHE A 371 70.643 -13.402 -13.923 1.00 11.72 C

ATOM 2788 CZ PHE A 371 71.994 -13.071 -13.829 1.00 11.48 C

ATOM 2789 CE2 PHE A 371 72.934 -14.068 -13.569 1.00 11.30 C

ATOM 2790 CD2 PHE A 371 72.521 -15.385 -13.397 1.00 11.47 C

ATOM 2791 C PHE A 371 70.500 -19.444 -14.300 1.00 11.44 C

ATOM 2792 O PHE A 371 71.536 -20.128 -14.323 1.00 11.27 O

ATOM 2793 N CYS A 372 69.297 -19.951 -14.030 1.00 11.66 N

ATOM 2794 CA CYS A 372 69.118 -21.292 -13.463 1.00 12.06 C

ATOM 2795 CB CYS A 372 68.282 -21.205 -12.183 1.00 11.73 C

ATOM 2796 SG CYS A 372 68.907 -20.039 -10.962 1.00 11.68

ATOM 2797 C CYS A 372 68.492 -22.330 -14.403 1.00 12.63 C

ATOM 2798 O CYS A 372 68.485 -23.525 -14.084 1.00 12.78 O

ATOM 2799 N ASN A 373 67.970 -21.873 -15.544 1.00 13.30 N

ATOM 2800 CA ASN A 373 67.220 -22.727 -16.486 1.00 14.15 C

ATOM 2801 CB ASN A 373 68.172 -23.622 -17.299 1.00 14.69 C

ATOM 2802 CG ASN A 373 67.515 -24.203 -18.539 1.00 16.32 C

ATOM 2803 ODl ASN A 373 67.120 -23.473 -19.452 1.00 18.68 O

ATOM 2804 ND2 ASN A 373 67.400 -25.527 -18.581 1.00 18.82 N

ATOM 2805 C ASN A 373 66.112 -23.556 -15.808 1.00 13.96 C

ATOM 2806 O ASN A 373 65.976 -24.758 -16.051 1.00 14.23 O

ATOM 2807 N GLN A 374 65.331 -22.901 -14.950 1.00 13.72 N

ATOM 2808 CA GLN A 374 64.247 -23.557 -14.219 1.00 13.35 C

ATOM 2809 CB GLN A 374 64.607 -23.682 -12.733 1.00 13.32 C

ATOM 2810 CG GLN A 374 65.721 -24.666 -12.441 1.00 13.32 C

ATOM 2811 CD GLN A 374 66.099 -24.722 -10.971 1.00 13.38 C

ATOM 2812 OEl GLN A 374 66.325 -23.693 -10.329 1.00 14.04 O

ATOM 2813 NE2 GLN A 374 66.184 -25.931 -10.435 1.00 12.48 N

ATOM 2814 C GLN A 374 62.932 -22.799 -14.376 1.00 13.36 C W2025-7029WO / AM102903-PCT

ATOM 2815 O GLN A 374 61.988 -23.004 -13.600 1.00 13.21 O

ATOM 2816 N GLY A 375 62.884 -21.922 -15.379 1.00 12.93 N

ATOM 2817 CA GLY A 375 61.751 -21.025 -15.589 1.00 12.66 C

ATOM 2818 C GLY A 375 61.925 -19.737 -14.806 1.00 12.34 C

ATOM 2819 O GLY A 375 62.863 -19.605 -14.012 1.00 12.65 O

ATOM 2820 N LYS A 376 61.022 -18.786 -15.030 1.00 11.74 N

ATOM 2821 CA LYS A 376 61.002 -17.534 -14.269 1.00 11.04 C

ATOM 2822 CB LYS A 376 60.171 -16.471 -14.995 1.00 11.24 C

ATOM 2823 CG LYS A 376 60.804 -16.001 -16.300 1.00 12.54 C

ATOM 2824 CD LYS A 376 59.900 -15.064 -17.075 1.00 14.76 C

ATOM 2825 CE LYS A 376 60.659 -14.429 -18.226 1.00 16.40 C

ATOM 2826 NZ LYS A 376 59.872 -13.356 -18.899 1.00 17.90 N

ATOM 2827 C LYS A 376 60.452 -17.787 -12.869 1.00 10.33 C

ATOM 2828 O LYS A 376 59.501 -18.552 -12.700 1.00 10.08 O

ATOM 2829 N PHE A 377 61.064 -17.144 -11.873 1.00 9.40 N

ATOM 2830 CA PHE A 377 60.730 -17.349 -10.458 1.00 8.56 C

ATOM 2831 CB PHE A 377 59.403 -16.665 -10.093 1.00 8.33 C

ATOM 2832 CG PHE A 377 59.446 -15.177 -10.161 1.00 8.51 C

ATOM 2833 CDl PHE A 377 60.062 -14.439 -9.151 1.00 8.36 C

ATOM 2834 CEl PHE A 377 60.093 -13.051 -9.209 1.00 8.09 C

ATOM 2835 CZ PHE A 377 59.497 -12.383 -10.281 1.00 8.14 C

ATOM 2836 CE2 PHE A 377 58.876 -13.109 -11.291 1.00 8.06 C

ATOM 2837 CD2 PHE A 377 58.850 -14.502 -11.224 1.00 7.84 C

ATOM 2838 C PHE A 377 60.645 -18.820 -10.055 1.00 8.15 C

ATOM 2839 O PHE A 377 59.607 -19.246 -9.551 1.00 7.83 O

ATOM 2840 N PRO A 378 61.733 -19.597 -10.253 1.00 7.80 N

ATOM 2841 CA PRO A 378 61.669 -21.037 -9.985 1.00 7.62 C

ATOM 2842 CB PRO A 378 63.068 -21.537 -10.371 1.00 7.74 C

ATOM 2843 CG PRO A 378 63.948 -20.328 -10.316 1.00 7.41 C

ATOM 2844 CD PRO A 378 63.073 -19.178 -10.710 1.00 7.82 C

ATOM 2845 C PRO A 378 61.348 -21.378 -8.520 1.00 7.63 C

ATOM 2846 O PRO A 378 60.537 -22.273 -8.259 1.00 7.83 O

ATOM 2847 N LEU A 379 61.954 -20.655 -7.583 1.00 7.60 N

ATOM 2848 CA LEU A 379 61.753 -20.915 -6.156 1.00 7.57 C

ATOM 2849 CB LEU A 379 62.844 -20.247 -5.313 1.00 7.57 C

ATOM 2850 CG LEU A 379 64.302 -20.661 -5.521 1.00 7.45 C

ATOM 2851 CDl LEU A 379 65.188 -19.912 -4.535 1.00 6.68 C

ATOM 2852 CD2 LEU A 379 64.482 -22.162 -5.370 1.00 6.38 C

ATOM 2853 C LEU A 379 60.369 -20.508 -5.645 1.00 7.66 C

ATOM 2854 O LEU A 379 59.754 -21.246 -4.876 1.00 7.93 O

ATOM 2855 N ILE A 380 59.877 -19.343 -6.058 1.00 7.68 N

ATOM 2856 CA ILE A 380 58.552 -18.901 -5.603 1.00 7.72 C

ATOM 2857 CB ILE A 380 58.360 -17.365 -5.658 1.00 7.75 C

ATOM 2858 CGl ILE A 380 59.484 -16.648 -4.891 1.00 7.42 C

ATOM 2859 CDl ILE A 380 59.447 -15.135 -4.984 1.00 7.33 C

ATOM 2860 CG2 ILE A 380 57.002 -16.984 -5.057 1.00 7.72 C

ATOM 2861 C ILE A 380 57.425 -19.634 -6.339 1.00 7.87 C

ATOM 2862 O ILE A 380 56.373 -19.903 -5.751 1.00 8.20 O

ATOM 2863 N SER A 381 57.648 -19.963 -7.612 1.00 7.92 N

ATOM 2864 CA SER A 381 56.721 -20.835 -8.356 1.00 8.18 C

ATOM 2865 CB SER A 381 57.184 -21.028 -9.804 1.00 8.09 C

ATOM 2866 OG SER A 381 57.181 -19.790 -10.508 1.00 10.10 O

ATOM 2867 C SER A 381 56.525 -22.194 -7.659 1.00 7.79 C

ATOM 2868 O SER A 381 55.409 -22.732 -7.639 1.00 7.97 O

ATOM 2869 N THR A 382 57.607 -22.733 -7.089 1.00 7.24 N

ATOM 2870 CA THR A 382 57.556 -23.974 -6.312 1.00 6.81 C

ATOM 2871 CB THR A 382 58.963 -24.378 -5.776 1.00 6.95 C

ATOM 2872 OGl THR A 382 59.878 -24.517 -6.872 1.00 7.85 O

ATOM 2873 CG2 THR A 382 58.909 -25.692 -4.996 1.00 7.00 C

ATOM 2874 C THR A 382 56.563 -23.854 -5.146 1.00 6.48 C

ATOM 2875 O THR A 382 55.754 -24.750 -4.917 1.00 5.85 O

ATOM 2876 N LEU A 383 56.632 -22.741 -4.422 1.00 6.16 N

ATOM 2877 CA LEU A 383 55.725 -22.493 -3.299 1.00 6.41 C W2025-7029WO / AM102903-PCT

ATOM 2878 CB LEU A 383 56.207 -21.308 -2.462 1.00 6.33 C

ATOM 2879 CG LEU A 383 57.648 -21.381 -1.948 1.00 5.69 C

ATOM 2880 CDl LEU A 383 57.965 -20.155 -1.102 1.00 5.91 C

ATOM 2881 CD2 LEU A 383 57.881 -22.665 -1.152 1.00 6.41 C

ATOM 2882 C LEU A 383 54.277 -22.293 -3.745 1.00 6.68 C

ATOM 2883 O LEU A 383 53.365 -22.804 -3.098 1.00 6.62 O

ATOM 2884 N LYS A 384 54.067 -21.573 -4.850 1.00 7.27 N

ATOM 2885 CA LYS A 384 52.711 -21.383 -5.390 1.00 7.86 C

ATOM 2886 CB LYS A 384 52.703 -20.491 -6.642 1.00 7.71 C

ATOM 2887 CG LYS A 384 51.287 -20.189 -7.165 1.00 7.95 C

ATOM 2888 CD LYS A 384 51.281 -19.428 -8.482 1.00 8.46 C

ATOM 2889 CE LYS A 384 49.842 -19.133 -8.922 1.00 9.45 C

ATOM 2890 NZ LYS A 384 49.769 -18.540 -10.296 1.00 11.66 N

ATOM 2891 C LYS A 384 52.062 -22.735 -5.691 1.00 8.25 C

ATOM 2892 O LYS A 384 50.926 -22.985 -5.285 1.00 7.93 O

ATOM 2893 N LYS A 385 52.803 -23.596 -6.390 1.00 8.92 N

ATOM 2894 CA LYS A 385 52.344 -24.945 -6.727 1.00 10.11 C

ATOM 2895 CB LYS A 385 53.340 -25.663 -7.647 1.00 9.82 C

ATOM 2896 CG LYS A 385 52.808 -26.984 -8.189 1.00 11.29 C

ATOM 2897 CD LYS A 385 53.749 -27.641 -9.188 1.00 11.68 C

ATOM 2898 CE LYS A 385 53.081 -28.868 -9.827 1.00 14.69 C

ATOM 2899 NZ LYS A 385 54.073 -29.873 -10.329 1.00 16.56 N

ATOM 2900 C LYS A 385 52.078 -25.786 -5.476 1.00 10.09 C

ATOM 2901 O LYS A 385 50.998 -26.356 -5.345 1.00 10.10 O

ATOM 2902 N ALA A 386 53.052 -25.840 -4.564 1.00 9.99 N

ATOM 2903 CA ALA A 386 52.944 -26.669 -3.361 1.00 10.67 C

ATOM 2904 CB ALA A 386 54.276 -26.723 -2.617 1.00 10.56 C

ATOM 2905 C ALA A 386 51.815 -26.245 -2.416 1.00 10.78 C

ATOM 2906 O ALA A 386 51.219 -27.087 -1.747 1.00 11.02 O

ATOM 2907 N LEU A 387 51.522 -24.947 -2.375 1.00 11.24 N

ATOM 2908 CA LEU A 387 50.474 -24.418 -1.501 1.00 11.72 C

ATOM 2909 CB LEU A 387 50.874 -23.046 -0.932 1.00 11.58 C

ATOM 2910 CG LEU A 387 52.144 -22.988 -0.061 1.00 11.70 C

ATOM 2911 CDl LEU A 387 52.469 -21.549 0.326 1.00 12.34 C

ATOM 2912 CD2 LEU A 387 52.037 -23.870 1.182 1.00 11.03 C

ATOM 2913 C LEU A 387 49.099 -24.368 -2.181 1.00 12.12 C

ATOM 2914 O LEU A 387 48.094 -24.017 -1.547 1.00 12.37 O

ATOM 2915 N GLY A 388 49.064 -24.734 -3.462 1.00 12.48 N

ATOM 2916 CA GLY A 388 47.818 -24.851 -4.221 1.00 13.00 C

ATOM 2917 C GLY A 388 47.054 -23.550 -4.375 1.00 13.38 C

ATOM 2918 O GLY A 388 45.816 -23.539 -4.336 1.00 13.40 O

ATOM 2919 N LEU A 389 47.788 -22.453 -4.550 1.00 13.48 N

ATOM 2920 CA LEU A 389 47.176 -21.136 -4.700 1.00 13.91 C

ATOM 2921 CB LEU A 389 48.229 -20.024 -4.739 1.00 13.89 C

ATOM 2922 CG LEU A 389 49.389 -19.999 -3.736 1.00 14.23 C

ATOM 2923 CDl LEU A 389 50.200 -18.743 -3.969 1.00 13.32 C

ATOM 2924 CD2 LEU A 389 48.917 -20.079 -2.287 1.00 13.21 C

ATOM 2925 C LEU A 389 46.303 -21.058 -5.949 1.00 14.35 C

ATOM 2926 O LEU A 389 46.695 -21.507 -7.032 1.00 14.07 O

ATOM 2927 N GLN A 390 45.113 -20.498 -5.768 1.00 14.89 N

ATOM 2928 CA GLN A 390 44.181 -20.221 -6.858 1.00 15.92 C

ATOM 2929 CB GLN A 390 42.794 -19.926 -6.255 1.00 15.95 C

ATOM 2930 CG GLN A 390 41.904 -18.935 -6.987 1.00 18.41 C

ATOM 2931 CD GLN A 390 42.294 -17.484 -6.740 1.00 19.59 C

ATOM 2932 OEl GLN A 390 42.203 -16.663 -7.637 1.00 21.94 O

ATOM 2933 NE2 GLN A 390 42.745 -17.173 -5.531 1.00 21.07 N

ATOM 2934 C GLN A 390 44.709 -19.084 -7.750 1.00 15.87 C

ATOM 2935 O GLN A 390 45.502 -18.250 -7.302 1.00 16.22 O

ATOM 2936 N SER A 391 44.289 -19.072 -9.013 1.00 15.96 N

ATOM 2937 CA SER A 391 44.682 -18.018 -9.947 1.00 15.87 C

ATOM 2938 CB SER A 391 45.664 -18.559 -10.985 1.00 15.78 C

ATOM 2939 OG SER A 391 46.905 -18.858 -10.376 1.00 16.42 O

ATOM 2940 C SER A 391 43.490 -17.340 -10.629 1.00 15.72 C W2025-7029WO / AM102903-PCT

ATOM 2941 O SER A 391 43.673 -16 479 -11.489 .00 15.85 O

ATOM 2942 N ALA A 392 42.279 -17 715 -10.221 .00 15.35 N

ATOM 2943 CA ALA A 392 41.043 -17 170 -10.788 .00 15.09 C

ATOM 2944 CB ALA A 392 39.831 -17 838 -10.150 .00 15.27 C

ATOM 2945 C ALA A 392 40.933 -15 649 -10.665 .00 14.92 C

ATOM 2946 O ALA A 392 40.331 -14 999 -11.519 .00 14.72 O

ATOM 2947 N SER A 393 41.524 -15 094 -9.605 .00 14.25 N

ATOM 2948 CA SER A 393 41.466 -13.663 -9.318 .00 13.75 C

ATOM 2949 CB SER A 393 41.864 -13.413 -7.863 .00 13.89 C

ATOM 2950 OG SER A 393 43.221 -13.765 -7.634 .00 13.12 O

ATOM 2951 C SER A 393 42.343 -12 823 -10.251 .00 13.49 C

ATOM 2952 O SER A 393 42.279 -11 593 -10.238 .00 13.51 O

ATOM 2953 N CYS A 394 43.153 -13.495 -11.062 .00 13.16 N

ATOM 2954 CA CYS A 394 44.056 -12.824 -11.989 1.00 12.86 C

ATOM 2955 CB CYS A 394 45.401 -13.544 -12.011 1.00 12.91 C

ATOM 2956 SG CYS A 394 46.026 -13.973 -10.375 1.00 13.65 S

ATOM 2957 C CYS A 394 43.470 -12.735 -13.401 1.00 12.65 C

ATOM 2958 O CYS A 394 44.152 -12.322 -14.349 1.00 12.46 O

ATOM 2959 N THR A 395 42.199 -13.109 -13.525 1.00 12.30 N

ATOM 2960 CA THR A 395 41.509 -13.136 -14.814 1.00 12.17 C

ATOM 2961 CB THR A 395 40.059 -13.676 -14.680 1.00 12.24 C

ATOM 2962 OGl THR A 395 39.397 -13.604 -15.950 1.00 12.75 O

ATOM 2963 CG2 THR A 395 39.267 -12.894 -13.638 1.00 11.76 C

ATOM 2964 C THR A 395 41.528 -11.786 -15.528 1.00 12.08 C

ATOM 2965 O THR A 395 41.497 -10.731 -14.887 1.00 12.02 O

ATOM 2966 N ALA A 396 41.617 -11.833 -16.854 1.00 11.87 N

ATOM 2967 CA ALA A 396 41.634 -10.625 -17.679 1.00 11.73 C

ATOM 2968 CB ALA A 396 43.045 -10.328 -18.175 1.00 11.76 C

ATOM 2969 C ALA A 396 40.669 -10.778 -18.851 1.00 11.38 C

ATOM 2970 O ALA A 396 40.762 -11.748 -19.608 1.00 11.20 O

ATOM 2971 N PRO A 397 39.728 -9.828 -18.991 1.00 11.17 N

ATOM 2972 CA PRO A 397 38.687 -9.919 -20.010 1.00 10.89 C

ATOM 2973 CB PRO A 397 37.582 -9.028 -19.444 1.00 11.00 C

ATOM 2974 CG PRO A 397 38.311 -7. -18.678 1.00 11.35 C

ATOM 2975 CD PRO A 397 39.573 -8. 623 -18.154 1.00 10.97 C

ATOM 2976 C PRO A 397 39.095 -9.431 -21.403 1.00 10.90 C

ATOM 2977 O PRO A 397 40.153 -8.805 -21.582 1.00 10.61 O

ATOM 2978 N ALA A 398 38.239 -9.721 -22.379 1.00 10.71 N

ATOM 2979 CA ALA A 398 38.343 -9.128 -23.705 1.00 10.62 C

ATOM 2980 CB ALA A 398 37.589 -9.973 -24.728 1.00 10.51 C

ATOM 2981 C ALA A 398 37.819 -7.681 -23.675 1.00 10.87 C

ATOM 2982 O ALA A 398 36.808 -7.344 -24.303 1.00 10.67 O

ATOM 2983 N GLN A 399 38.510 846 -22.902 1.00 11.16 N

ATOM 2984 CA GLN A 399 38.277 -5.405 -22.843 1.00 11.51 C

ATOM 2985 CB GLN A 399 37.458 -5.022 -21.599 1.00 11.46 C

ATOM 2986 CG GLN A 399 36.047 -5.620 -21.559 1.00 10.50 C

ATOM 2987 CD GLN A 399 35.246 -5.240 -20.313 1.00 10.66 C

ATOM 2988 OEl GLN A 399 35.247 -4.090 -19.881 1.00 9.44 O

ATOM 2989 NE2 GLN A 399 34.532 -6.208 -19.755 1.00 9.61 N

ATOM 2990 C GLN A 399 39.668 -4.752 -22.833 1.00 12.41 C

ATOM 2991 O GLN A 399 40.527 -5.155 -22.051 1.00 12.65 O

ATOM 2992 N PRO A 400 39.903 -3.760 -23.712 1.00 13.26 N

ATOM 2993 CA PRO A 400 41.273 -3.272 -23.968 1.00 13.91 C

ATOM 2994 CB PRO A 400 41.110 -2.412 -25.227 1.00 14.31 C

ATOM 2995 CG PRO A 400 39.686 -1.912 -25.151 1.00 14.12 C

ATOM 2996 CD PRO A 400 38.896 -3.031 -24.509 1.00 13.62 C

ATOM 2997 C PRO A 400 41.871 -2.444 -22.830 1.00 14.33 C

ATOM 2998 O PRO A 400 41.151 -2.026 -21.923 1.00 15.11 O

ATOM 2999 N TYR B 22 7.702 -18.648 28.634 1.00 11.89 N

ATOM 3000 CA TYR B 22 9.092 -18.407 29.119 1.00 11.99 C

ATOM 3001 CB TYR B 22 10.065 -19.436 28.524 1.00 12.34 C

ATOM 3002 CG TYR B 22 9.724 -20.866 28.865 1.00 12.94 C

ATOM 3003 CDl TYR B 22 9.122 -21.697 27.925 1.00 12.97 C W2025-7029WO / AM102903-PCT

ATOM 3004 CEl TYR B 22 8.793 -23.013 28.233 1.00 13.97 C

ATOM 3005 CZ TYR B 22 9.074 -23.508 29.493 1.00 13.58 C

ATOM 3006 OH TYR B 22 8.756 -24.811 29.793 1.00 14.09 O

ATOM 3007 CE2 TYR B 22 9.679 -22.704 30.448 1.00 13.95 C

ATOM 3008 CD2 TYR B 22 10.001 -21.389 30.130 1.00 13.47 C

ATOM 3009 C TYR B 22 9.572 -16.996 28.793 1.00 11.57 C

ATOM 3010 O TYR B 22 9.176 -16.407 27.782 1.00 11.34 O

ATOM 3011 N GLN B 23 10.421 -16.465 29.668 1.00 10.95 N

ATOM 3012 CA GLN B 23 11.099 -15.194 29.439 1.00 10.55 C

ATOM 3013 CB GLN B 23 11.270 -14.424 30.755 1.00 10.70 C

ATOM 3014 CG GLN B 23 9.968 -14.039 31.450 1.00 12.88 C

ATOM 3015 CD GLN B 23 9.156 -13.016 30.672 1.00 15.59 C

ATOM 3016 OEl GLN B 23 9.710 -12.168 29.967 1.00 18.37 O

ATOM 3017 NE2 GLN B 23 7.834 -13.086 30.805 1.00 16.61 N

ATOM 3018 C GLN B 23 12.473 -15.449 28.836 1.00 9.85 C

ATOM 3019 O GLN B 23 13.115 -16.458 29.145 1.00 9.54 O

ATOM 3020 N LEU B 24 12.902 -14.544 27.960 1.00 8.99 N

ATOM 3021 CA LEU B 24 14.299 -14.470 27.533 1.00 8.33 C

ATOM 3022 CB LEU B 24 14.481 -14.850 26.058 1.00 7.97 C

ATOM 3023 CG LEU B 24 15.914 -14.772 25.502 1.00 7.75 C

ATOM 3024 CDl LEU B 24 16.906 -15.584 26.337 1.00 7.35 C

ATOM 3025 CD2 LEU B 24 15.960 -15.207 24.051 1.00 7.84 C

ATOM 3026 C LEU B 24 14.776 -13.049 27.793 1.00 8.06 C

ATOM 3027 O LEU B 24 14.379 -12.110 27.098 1.00 7.84 O

ATOM 3028 N THR B 25 15.608 -12.909 28.819 1.00 7.83 N

ATOM 3029 CA THR B 25 16.029 -11.612 29.324 1.00 7.66 C

ATOM 3030 CB THR B 25 15.848 -11.536 30.863 1.00 7.57 C

ATOM 3031 OGl THR B 25 14.456 -11.620 31.194 1.00 7.76 O

ATOM 3032 CG2 THR B 25 16.409 -10.249 31.427 1.00 7.50 C

ATOM 3033 C THR B 25 17.482 -11.377 28.927 1.00 7.82 C

ATOM 3034 O THR B 25 18.373 -12.119 29.333 1.00 7.91 O

ATOM 3035 N CYS B 26 17.716 -10.348 28.122 1.00 7.84 N

ATOM 3036 CA CYS B 26 19.048 -10.108 27.567 1.00 7.77 C

ATOM 3037 CB CYS B 26 18.982 -10.108 26.034 1.00 8.00 C

ATOM 3038 SG CYS B 26 18.181 -11.595 25.341 1.00 10.01 S

ATOM 3039 C CYS B 26 19.651 -8.810 28.100 1.00 7.47 C

ATOM 3040 O CYS B 26 19.044 -7.744 27.980 1.00 7.12 O

ATOM 3041 N TYR B 27 20.838 -8.912 28.704 1.00 7.21 N

ATOM 3042 CA TYR B 27 21.544 -7.746 29.230 1.00 7.04 C

ATOM 3043 CB TYR B 27 22.475 -8.141 30.382 1.00 7.31 C

ATOM 3044 CG TYR B 27 21.810 -8.408 31.719 1.00 6.99 C

ATOM 3045 CDl TYR B 27 21.744 -7.412 32.694 1.00 7.74 C

ATOM 3046 CEl TYR B 27 21.144 -7.649 33.939 1.00 8.19 C

ATOM 3047 CZ TYR B 27 20.616 -8.908 34.223 1.00 7.69 C

ATOM 3048 OH TYR B 27 20.038 -9.131 35.458 1.00 7.24 O

ATOM 3049 CE2 TYR B 27 20.678 -9.923 33.279 1.00 6.95 C

ATOM 3050 CD2 TYR B 27 21.282 -9.670 32.028 1.00 7.73 C

ATOM 3051 C TYR B 27 22.369 -7.045 28.150 1.00 7.17 C

ATOM 3052 O TYR B 27 23.160 -7.689 27.443 1.00 6.84 O

ATOM 3053 N PHE B 28 22.174 -5.730 28.041 1.00 6.92 N

ATOM 3054 CA PHE B 28 22.994 -4.849 27.210 1.00 6.95 C

ATOM 3055 CB PHE B 28 22.100 -3.864 26.441 1.00 6.94 C

ATOM 3056 CG PHE B 28 22.835 -2.679 25.856 1.00 6.95 C

ATOM 3057 CDl PHE B 28 23.509 -2.787 24.642 1.00 6.34 C

ATOM 3058 CEl PHE B 28 24.181 -1.688 24.097 1.00 6.99 C

ATOM 3059 CZ PHE B 28 24.176 -0.461 24.773 1.00 7.27 C

ATOM 3060 CE2 PHE B 28 23.496 -0.344 25.981 1.00 6.24 C

ATOM 3061 CD2 PHE B 28 22.827 -1.443 26.512 1.00 6.78 C

ATOM 3062 C PHE B 28 23.949 -4.093 28.122 1.00 6.82 C

ATOM 3063 O PHE B 28 23.551 -3.634 29.193 1.00 6.99 O

ATOM 3064 N THR B 29 25.207 -3.973 27.708 1.00 6.63 N

ATOM 3065 CA THR B 29 26.201 -3.260 28.514 1.00 6.51 C

ATOM 3066 CB THR B 29 27.402 -4.157 28.864 1.00 6.36 C W2025-7029WO / AM102903-PCT

ATOM 3067 OGl THR B 29 28.136 -4.484 27.677 1.00 6.08 O

ATOM 3068 CG2 THR B 29 26.928 -5.450 29.535 1.00 6.11 C

ATOM 3069 C THR B 29 26.654 -1.958 27.847 1.00 6.60 C

ATOM 3070 O THR B 29 26.991 -1.942 26.660 1.00 6.54 O

ATOM 3071 N ASN B 30 26.657 -0.874 28.627 1.00 6.74 N

ATOM 3072 CA ASN B 30 26.946 0.475 28.116 1.00 6.90 C

ATOM 3073 CB ASN B 30 26.275 1.559 28.988 1.00 6.81 C

ATOM 3074 CG ASN B 30 26.743 1.542 30.454 1.00 7.28 C

ATOM 3075 ODl ASN B 30 27.561 0.714 30.865 1.00 6.72 O

ATOM 3076 ND2 ASN B 30 26.217 2.477 31.245 1.00 6.20 N

ATOM 3077 C ASN B 30 28.442 0.771 27.900 1.00 6.96 C

ATOM 3078 O ASN B 30 28.812 1.889 27.539 1.00 6.81 O

ATOM 3079 N TRP B 31 29.288 -0.239 28.099 1.00 7.15 N

ATOM 3080 CA TRP B 31 30.720 -0.117 27.787 1.00 7.22 C

ATOM 3081 CB TRP B 31 31.588 -0.583 28.968 1.00 7.07 C

ATOM 3082 CG TRP B 31 31.387 -2.023 29.372 1.00 7.23 C

ATOM 3083 CDl TRP B 31 32.035 -3.114 28.865 1.00 7.01 C

ATOM 3084 NEl TRP B 31 31.591 -4.260 29.479 1.00 7.06 N

ATOM 3085 CE2 TRP B 31 30.646 -3.928 30.414 1.00 6.49 C

ATOM 3086 CD2 TRP B 31 30.490 -2.522 30.376 1.00 6.74 C

ATOM 3087 CE3 TRP B 31 29.570 -1.921 31.247 1.00 7.03 C

ATOM 3088 CZ3 TRP B 31 28.841 -2.731 32.115 1.00 6.96 C

ATOM 3089 CH2 TRP B 31 29.022 -4.128 32.130 1.00 6.90 C

ATOM 3090 CZ2 TRP B 31 29.917 -4.742 31.287 1.00 6.60 C

ATOM 3091 C TRP B 31 31.096 -0.843 26.487 1.00 7.39 C

ATOM 3092 O TRP B 31 32.243 -0.753 26.012 1.00 7.24 O

ATOM 3093 N ALA B 32 30.128 -1.549 25.902 1.00 7.78 N

ATOM 3094 CA ALA B 32 30.335 -2.236 24.622 1.00 8.22 C

ATOM 3095 CB ALA B 32 29.204 -3.204 24.337 1.00 8.42 C

ATOM 3096 C ALA B 32 30.513 -1.255 23.463 1.00 8.70 C

ATOM 3097 O ALA B 32 31.078 -1.607 22.416 1.00 8.70 O

ATOM 3098 N GLN B 33 30.041 -0.025 23.665 1.00 8.93 N

ATOM 3099 CA GLN B 33 30.230 1.068 22.709 1.00 9.30 C

ATOM 3100 CB GLN B 33 29.460 2.317 23.159 1.00 9.10 C

ATOM 3101 CG GLN B 33 29.892 2.891 24.501 1.00 9.59 C

ATOM 3102 CD GLN B 33 29.263 4.241 24.804 1.00 9.50 C

ATOM 3103 OEl GLN B 33 29.382 5.186 24.024 1.00 8.95 O

ATOM 3104 NE2 GLN B 33 28.603 4.341 25.952 1.00 8.41 N

ATOM 3105 C GLN B 33 31.709 1.414 22.473 1.00 9.40 C

ATOM 3106 O GLN B 33 32.062 1.938 21.419 1.00 9.66 O

ATOM 3107 N TYR B 34 32.570 1.119 23.446 1.00 9.57 N

ATOM 3108 CA TYR B 34 33.981 1.515 23.353 1.00 9.72 C

ATOM 3109 CB TYR B 34 34.549 1.868 24.734 1.00 10.01 C

ATOM 3110 CG TYR B 34 33.755 2.930 25.471 1.00 10.30 C

ATOM 3111 CDl TYR B 34 33.599 4.213 24.941 1.00 11.05 C

ATOM 3112 CEl TYR B 34 32.865 5.185 25.615 1.00 10.97 C

ATOM 3113 CZ TYR B 34 32.283 4.869 26.836 1.00 10.77 C

ATOM 3114 OH TYR B 34 31.556 5.816 27.510 1.00 10.81 O

ATOM 3115 CE2 TYR B 34 32.423 3.603 27.377 1.00 10.19 C

ATOM 3116 CD2 TYR B 34 33.155 2.645 26.697 1.00 9.93 C

ATOM 3117 C TYR B 34 34.865 0.486 22.644 1.00 9.43 C

ATOM 3118 O TYR B 34 36.068 0.700 22.465 1.00 9.25 O

ATOM 3119 N ARG B 35 34.262 -0.624 22.238 1.00 9.20 N

ATOM 3120 CA ARG B 35 34.981 -1.687 21.549 1.00 8.89 C

ATOM 3121 CB ARG B 35 34.191 -2.992 21.637 1.00 8.85 C

ATOM 3122 CG ARG B 35 34.013 -3.479 23.074 1.00 8.82 C

ATOM 3123 CD ARG B 35 33.231 -4.772 23.182 1.00 8.69 C

ATOM 3124 NE ARG B 35 33.030 -5.107 24.591 1.00 8.78 N

ATOM 3125 CZ ARG B 35 31.987 -5.772 25.073 1.00 7.28 C

ATOM 3126 NHl ARG B 35 31.028 -6.201 24.265 1.00 6.29 N

ATOM 3127 NH2 ARG B 35 31.909 -6.010 26.376 1.00 7.11 N

ATOM 3128 C ARG B 35 35.277 -1.280 20.098 1.00 9.18 C

ATOM 3129 O ARG B 35 34.438 -0.650 19.448 1.00 9.08 O W2025-7029WO / AM102903-PCT

ATOM 3130 N PRO B 36 36.488 -1.603 19.600 1.00 9.12 N

ATOM 3131 CA PRO B 36 36.922 -1.141 18.275 1.00 8.94 C

ATOM 3132 CB PRO B 36 38.412 -1.483 18.258 1.00 8.92 C

ATOM 3133 CG PRO B 36 38.537 -2.637 19.187 1.00 9.17 C

ATOM 3134 CD PRO B 36 37.531 -2.403 20.273 1.00 8.79 C

ATOM 3135 C PRO B 36 36.208 -1.806 17.092 1.00 9.13 C

ATOM 3136 O PRO B 36 35.951 -3.011 17.115 1.00 8.78 O

ATOM 3137 N GLY B 37 35.889 -1.006 16.075 1.00 9.51 N

ATOM 3138 CA GLY B 37 35.310 -1.500 14.820 1.00 9.99 C

ATOM 3139 C GLY B 37 34.154 -2.468 14.990 1.00 10.46 C

ATOM 3140 O GLY B 37 33.116 -2.111 15.551 1.00 10.23 O

ATOM 3141 N LEU B 38 34.356 -3.700 14.521 1.00 10.78 N

ATOM 3142 CA LEU B 38 33.338 -4.762 14.560 1.00 11.40 C

ATOM 3143 CB LEU B 38 33.845 -6.020 13.837 1.00 11.56 C

ATOM 3144 CG LEU B 38 33.906 -5.983 12.304 1.00 12.75 C

ATOM 3145 CDl LEU B 38 34.713 -7.161 11.760 1.00 14.14 C

ATOM 3146 CD2 LEU B 38 32.502 -5.986 11.715 1.00 12.85 C

ATOM 3147 C LEU B 38 32.862 -5.123 15.971 1.00 11.44 C

ATOM 3148 O LEU B 38 31.763 -5.668 16.142 1.00 11.78 O

ATOM 3149 N GLY B 39 33.689 -4.817 16.968 1.00 11.20 N

ATOM 3150 CA GLY B 39 33.360 -5.067 18.367 1.00 11.25 C

ATOM 3151 C GLY B 39 32.316 -4.123 18.942 1.00 11.40 C

ATOM 3152 O GLY B 39 31.626 -4.472 19.902 1.00 11.36 O

ATOM 3153 N ARG B 40 32.201 -2.930 18.351 1.00 11.19 N

ATOM 3154 CA ARG B 40 31.309 -1.878 18.849 1.00 10.99 C

ATOM 3155 CB ARG B 40 31.545 -0.578 18.073 1.00 11.29 C

ATOM 3156 CG ARG B 40 30.651 0.594 18.450 1.00 12.62 C

ATOM 3157 CD ARG B 40 31.001 1.786 17.567 1.00 16.47 C

ATOM 3158 NE ARG B 40 29.940 2.788 17.502 1.00 19.08 N

ATOM 3159 CZ ARG B 40 29.836 3.836 18.318 1.00 20.48 C

ATOM 3160 NHl ARG B 40 28.834 4.691 18.159 1.00 21.10 N

ATOM 3161 NH2 ARG B 40 30.724 4.032 19.293 1.00 20.86 N

ATOM 3162 C ARG B 40 29.837 -2.289 18.781 1.00 10.55 C

ATOM 3163 O ARG B 40 29.334 -2.678 17.726 1.00 10.05 O

ATOM 3164 N PHE B 41 29.159 -2.192 19.921 1.00 10.24 N

ATOM 3165 CA PHE B 41 27.762 -2.591 20.017 1.00 10.03 C

ATOM 3166 CB PHE B 41 27.629 -3.933 20.751 1.00 9.59 C

ATOM 3167 CG PHE B 41 26.253 -4.530 20.678 1.00 9.02 C

ATOM 3168 CDl PHE B 41 25.969 -5.533 19.757 1.00 8.23 C

ATOM 3169 CEl PHE B 41 24.697 -6.096 19.678 1.00 8.67 C

ATOM 3170 CZ PHE B 41 23.688 -5.648 20.531 1.00 8.30 C

ATOM 3171 CE2 PHE B 41 23.961 -4.638 21.461 1.00 8.15 C

ATOM 3172 CD2 PHE B 41 25.237 -4.089 21.530 1.00 8.46 C

ATOM 3173 C PHE B 41 26.923 -1.517 20.701 1.00 10.03 C

ATOM 3174 O PHE B 41 27.173 -1.146 21.856 1.00 9.70 O

ATOM 3175 N MET B 42 25.924 -1.038 19.966 1.00 10.14 N

ATOM 3176 CA MET B 42 25.050 0.042 20.406 1.00 10.23 C

ATOM 3177 CB MET B 42 25.103 1.198 19.397 1.00 10.74 C

ATOM 3178 CG MET B 42 26.507 1.684 19.050 1.00 12.13 C

ATOM 3179 SD MET B 42 27.362 2.450 20.438 1.00 15.60 S

ATOM 3180 CE MET B 42 26.533 4.033 20.520 1.00 14.82 C

ATOM 3181 C MET B 42 23.624 -0.497 20.513 1.00 10.21 C

ATOM 3182 O MET B 42 23.327 -1.552 19.942 1.00 9.77 O

ATOM 3183 N PRO B 43 22.736 0.212 21.246 1.00 10.14 N

ATOM 3184 CA PRO B 43 21.340 -0.227 21.361 1.00 10.16 C

ATOM 3185 CB PRO B 43 20.658 0.964 22.035 1.00 10.21 C

ATOM 3186 CG PRO B 43 21.735 1.558 22.872 1.00 10.07 C

ATOM 3187 CD PRO B 43 22.977 1.442 22.029 1.00 10.19 C

ATOM 3188 C PRO B 43 20.658 -0.565 20.028 1.00 10.31 C

ATOM 3189 O PRO B 43 19.896 -1.529 19.965 1.00 10.40 O

ATOM 3190 N ASP B 44 20.932 0.194 18.968 1.00 10.22 N

ATOM 3191 CA ASP B 44 20.293 -0.087 17.672 1.00 10.14 C

ATOM 3192 CB ASP B 44 20.267 1.157 16.777 1.00 10.49 C W2025-7029WO / AM102903-PCT

ATOM 3193 CG ASP B 44 19.221 2.174 17.227 1.00 12.18 C

ATOM 3194 ODl ASP B 44 18.002 1.878 17.151 1.00 13.12 O

ATOM 3195 OD2 ASP B 44 19.620 3.273 17.662 1.00 13.22 O

ATOM 3196 C ASP B 44 20.831 -1.337 16.938 1.00 9.62 C

ATOM 3197 O ASP B 44 20.311 -1.712 15.885 1.00 9.51 O

ATOM 3198 N ASP B 45 21.847 -1.983 17.514 1.00 8.84 N

ATOM 3199 CA ASP B 45 22.321 -3.286 17.043 1.00 8.43 C

ATOM 3200 CB ASP B 45 23.806 -3.471 17.368 1.00 8.34 C

ATOM 3201 CG ASP B 45 24.681 -2.441 16.689 1.00 8.84 C

ATOM 3202 ODl ASP B 45 24.575 -2.293 15.453 1.00 9.67 O

ATOM 3203 OD2 ASP B 45 25.475 -1.778 17.388 1.00 8.29 O

ATOM 3204 C ASP B 45 21.507 -4.456 17.616 1.00 7.95 C

ATOM 3205 O ASP B 45 21.745 -5.611 17.268 1.00 7.62 O

ATOM 3206 N ILE B 46 20.561 -4.148 18.501 1.00 7.65 N

ATOM 3207 CA ILE B 46 19.701 -5.154 19.109 1.00 7.38 C

ATOM 3208 CB ILE B 46 19.169 -4.689 20.503 1.00 7.35 C

ATOM 3209 CGl ILE B 46 20.318 -4.530 21.507 1.00 7.31 C

ATOM 3210 CDl ILE B 46 19.932 -3.786 22.773 1.00 7.08 C

ATOM 3211 CG2 ILE B 46 18.098 -5.647 21.042 1.00 6.65 C

ATOM 3212 C ILE B 46 18.528 -5.437 18.180 1.00 7.47 C

ATOM 3213 O ILE B 46 17.877 -4.511 17.701 1.00 7.29 O

ATOM 3214 N ASN B 47 18.278 -6.718 17.916 1.00 7.75 N

ATOM 3215 CA ASN B 47 17.085 -7.149 17.207 1.00 7.83 C

ATOM 3216 CB ASN B 47 17.318 -8.543 16.594 1.00 8.15 C

ATOM 3217 CG ASN B 47 16.126 -9.058 15.785 1.00 8.29 C

ATOM 3218 ODl ASN B 47 14.989 -8.624 15.960 1.00 9.94 O

ATOM 3219 ND2 ASN B 47 16.391 -10.008 14.907 1.00 9.66 N

ATOM 3220 C ASN B 47 15.926 -7.162 18.212 1.00 7.93 C

ATOM 3221 O ASN B 47 15.963 -7.917 19.180 1.00 7.99 O

ATOM 3222 N PRO B 48 14.904 -6.307 17.999 1.00 8.14 N

ATOM 3223 CA PRO B 48 13.785 -6.179 18.954 1.00 8.23 C

ATOM 3224 CB PRO B 48 12.937 -5.047 18.355 1.00 8.38 C

ATOM 3225 CG PRO B 48 13.305 -5.014 16.910 1.00 8.70 C

ATOM 3226 CD PRO B 48 14.749 -5.399 16.847 1.00 8.01 C

ATOM 3227 C PRO B 48 12.933 -7.440 19.125 1.00 8.24 C

ATOM 3228 O PRO B 48 12.149 -7.532 20.076 1.00 8.07 O

ATOM 3229 N CYS B 49 13.093 -8.397 18.213 1.00 8.46 N

ATOM 3230 CA CYS B 49 12.280 -9.609 18.199 1.00 8.72 C

ATOM 3231 CB CYS B 49 11.792 -9.886 16.776 1.00 8.65 C

ATOM 3232 SG CYS B 49 10.584 -8.665 16.231 1.00 9.48 S

ATOM 3233 C CYS B 49 13.000 -10.827 18.786 1.00 8.93 C

ATOM 3234 O CYS B 49 12.471 -11.942 18.772 1.00 8.98 O

ATOM 3235 N LEU B 50 14.190 -10.599 19.332 1.00 8.96 N

ATOM 3236 CA LEU B 50 15.010 -11.675 19.879 1.00 9.39 C

ATOM 3237 CB LEU B 50 16.485 -11.281 19.783 1.00 9.43 C

ATOM 3238 CG LEU B 50 17.571 -12.350 19.738 1.00 10.78 C

ATOM 3239 CDl LEU B 50 17.332 -13.397 18.634 1.00 10.47 C

ATOM 3240 CD2 LEU B 50 18.916 -11.660 19.564 1.00 10.25 C

ATOM 3241 C LEU B 50 14.645 -12.037 21.320 1.00 8.93 C

ATOM 3242 O LEU B 50 14.473 -13.213 21.647 1.00 8.76 O

ATOM 3243 N CYS B 51 14.540 -11.025 22.179 1.00 8.63 N

ATOM 3244 CA CYS B 51 14.315 -11.236 23.605 1.00 8.38 C

ATOM 3245 CB CYS B 51 15.449 -10.602 24.419 1.00 8.28 C

ATOM 3246 SG CYS B 51 17.117 -10.907 23.746 1.00 8.46

ATOM 3247 C CYS B 51 12.957 -10.679 24.038 1.00 8.36 C

ATOM 3248 O CYS B 51 12.390 -9.817 23.360 1.00 8.74 O

ATOM 3249 N THR B 52 12.430 -11.185 25.149 1.00 8.17 N

ATOM 3250 CA THR B 52 11.182 -10.653 25.719 1.00 8.25 C

ATOM 3251 CB THR B 52 10.380 -11.726 26.496 1.00 8.18 C

ATOM 3252 OGl THR B 52 11.180 -12.260 27.558 1.00 8.12 O

ATOM 3253 CG2 THR B 52 9.944 -12.866 25.570 1.00 8.72 C

ATOM 3254 C THR B 52 11.460 -9.460 26.639 1.00 8.20 C

ATOM 3255 O THR B 52 10.656 -8.520 26.725 1.00 8.15 O W2025-7029WO / AM102903-PCT

ATOM 3256 N HIS B 53 12.598 -9.522 27.328 1.00 8.20 N

ATOM 3257 CA HIS B 53 13.044 -8.486 28.251 1.00 8.15 C

ATOM 3258 CB HIS B 53 13.055 -9.030 29.684 1.00 8.62 C

ATOM 3259 CG HIS B 53 11.702 -9.108 30.328 1.00 9.96 C

ATOM 3260 NDl HIS B 53 10.526 -9.011 29.619 1.00 11.97 N

ATOM 3261 CEl HIS B 53 9.501 -9.125 30.444 1.00 11.19 C

ATOM 3262 NE2 HIS B 53 9.970 -9.307 31.663 1.00 10.84 N

ATOM 3263 CD2 HIS B 53 11.344 -9.311 31.617 1.00 11.18 C

ATOM 3264 C HIS B 53 14.463 -8.050 27.874 1.00 7.89 C

ATOM 3265 O HIS B 53 15.306 -8.893 27.553 1.00 7.71 O

ATOM 3266 N LEU B 54 14.716 -6.741 27.902 1.00 7.31 N

ATOM 3267 CA LEU B 54 16.063 -6.203 27.699 1.00 6.89 C

ATOM 3268 CB LEU B 54 16.130 -5.325 26.442 1.00 7.07 C

ATOM 3269 CG LEU B 54 15.889 -5.940 25.059 1.00 7.21 C

ATOM 3270 CDl LEU B 54 15.837 -4.837 24.021 1.00 7.55 C

ATOM 3271 CD2 LEU B 54 16.951 -6.987 24.677 1.00 7.66 C

ATOM 3272 C LEU B 54 16.486 -5.404 28.926 1.00 6.80 C

ATOM 3273 O LEU B 54 15.740 -4.538 29.396 1.00 6.81 O

ATOM 3274 N ILE B 55 17.669 -5.699 29.458 1.00 6.45 N

ATOM 3275 CA ILE B 55 18.157 -4.991 30.646 1.00 6.38 C

ATOM 3276 CB ILE B 55 18.365 -5.937 31.866 1.00 6.34 C

ATOM 3277 CGl ILE B 55 17.078 -6.722 32.160 1.00 6.32 C

ATOM 3278 CDl ILE B 55 17.053 -7.453 33.498 1.00 6.60 C

ATOM 3279 CG2 ILE B 55 18.828 -5.135 33.084 1.00 6.12 C

ATOM 3280 C ILE B 55 19.420 -4.182 30.360 1.00 6.38 C

ATOM 3281 O ILE B 55 20.386 -4.705 29.808 1.00 6.23 O

ATOM 3282 N TYR B 56 19.381 -2.904 30.741 1.00 6.40 N

ATOM 3283 CA TYR B 56 20.471 -1.956 30.518 1.00 6.50 C

ATOM 3284 CB TYR B 56 19.880 -0.552 30.311 1.00 6.68 C

ATOM 3285 CG TYR B 56 20.817 0.492 29.729 1.00 7.03 C

ATOM 3286 CDl TYR B 56 20.640 0.959 28.427 1.00 7.58 C

ATOM 3287 CEl TYR B 56 21.487 1.931 27.885 1.00 6.97 C

ATOM 3288 CZ TYR B 56 22.520 2.440 28.655 1.00 7.23 C

ATOM 3289 OH TYR B 56 23.361 3.388 28.125 1.00 6.95 O

ATOM 3290 CE2 TYR B 56 22.715 1.995 29.955 1.00 6.44 C

ATOM 3291 CD2 TYR B 56 21.860 1.034 30.488 1.00 6.81 C

ATOM 3292 C TYR B 56 21.432 -1.951 31.716 1.00 6.36 C

ATOM 3293 O TYR B 56 21.046 -1.569 32.819 1.00 6.09 O

ATOM 3294 N ALA B 57 22.680 -2.362 31.486 1.00 6.31 N

ATOM 3295 CA ALA B 57 23.731 -2.317 32.509 1.00 6.43 C

ATOM 3296 CB ALA B 57 24.377 -3.692 32.643 1.00 6.43 C

ATOM 3297 C ALA B 57 24.794 -1.256 32.161 1.00 6.75 C

ATOM 3298 O ALA B 57 25.276 -1.234 31.033 1.00 6.74 O

ATOM 3299 N PHE B 58 25.167 -0.370 33.089 1.00 7.32 N

ATOM 3300 CA PHE B 58 24.594 -0.232 34.434 1.00 7.64 C

ATOM 3301 CB PHE B 58 25.603 -0.678 35.504 1.00 7.49 C

ATOM 3302 CG PHE B 58 25.804 -2.165 35.591 1.00 7.26 C

ATOM 3303 CDl PHE B 58 27.030 -2.732 35.240 1.00 6.56 C

ATOM 3304 CEl PHE B 58 27.237 -4.113 35.336 1.00 6.12 C

ATOM 3305 CZ PHE B 58 26.208 -4.936 35.785 1.00 6.30 C

ATOM 3306 CE2 PHE B 58 24.979 -4.378 36.146 1.00 6.61 C

ATOM 3307 CD2 PHE B 58 24.787 -2.995 36.055 1.00 6.73 C

ATOM 3308 C PHE B 58 24.282 1.241 34.717 1.00 8.24 C

ATOM 3309 O PHE B 58 24.859 2.134 34.086 1.00 7.90 O

ATOM 3310 N ALA B 59 23.389 1.473 35.687 1.00 8.77 N

ATOM 3311 CA ALA B 59 23.189 2.779 36.311 1.00 9.33 C

ATOM 3312 CB ALA B 59 21.707 3.008 36.600 1.00 9.35 C

ATOM 3313 C ALA B 59 23.991 2.859 37.613 1.00 9.88 C

ATOM 3314 O ALA B 59 24.370 1.827 38.186 1.00 10.04 O

ATOM 3315 N GLY B 60 24.234 4.085 38.077 1.00 10.36 N

ATOM 3316 CA GLY B 60 24.967 4.333 39.316 1.00 11.24 C

ATOM 3317 C GLY B 60 24.112 4.961 40.404 1.00 11.93 C

ATOM 3318 O GLY B 60 22.878 4.941 40.332 1.00 11.41 O W2025-7029WO / AM102903-PCT

ATOM 3319 N MET B 61 24.777 5.508 41.421 1.00 12.55 N

ATOM 3320 CA MET B 61 24.096 6.135 42.552 1.00 13.70 C

ATOM 3321 CB MET B 61 23.819 5.111 43.661 1.00 13.58 C

ATOM 3322 CG MET B 61 22.772 5.556 44.686 1.00 13.67 C

ATOM 3323 SD MET B 61 22.782 4.610 46.233 1.00 14.08

ATOM 3324 CE MET B 61 22.420 2.952 45.651 1.00 12.19 C

ATOM 3325 C MET B 61 24.931 7.287 43.100 1.00 14.39 C

ATOM 3326 O MET B 61 26.149 7.163 43.258 1.00 14.35 O

ATOM 3327 N GLN B 62 24.266 8.409 43.367 1.00 15.47 N

ATOM 3328 CA GLN B 62 24.889 9.574 43.991 1.00 16.48 C

ATOM 3329 CB GLN B 62 25.340 10.598 42.944 1.00 16.91 C

ATOM 3330 CG GLN B 62 26.436 10.110 41.982 1.00 19.28 C

ATOM 3331 CD GLN B 62 27.744 9.751 42.679 1.00 22.14 C

ATOM 3332 OEl GLN B 62 28.135 10.381 43.668 1.00 24.96 O

ATOM 3333 NE2 GLN B 62 28.431 8.737 42.159 1.00 23.09 N

ATOM 3334 C GLN B 62 23.886 10.207 44.943 1.00 16.44 C

ATOM 3335 O GLN B 62 22.725 10.409 44.579 1.00 16.33 O

ATOM 3336 N ASN B 63 24.342 10.506 46.159 1.00 16.67 N

ATOM 3337 CA ASN B 63 23.493 11.083 47.213 1.00 16.73 C

ATOM 3338 CB ASN B 63 23.200 12.568 46.934 1.00 16.82 C

ATOM 3339 CG ASN B 63 24.466 13.399 46.759 1.00 17.99 C

ATOM 3340 ODl ASN B 63 25.452 13.223 47.484 1.00 19.47 O

ATOM 3341 ND2 ASN B 63 24.438 14.322 45.801 1.00 18.04 N

ATOM 3342 C ASN B 63 22.202 10.285 47.410 1.00 16.31 C

ATOM 3343 O ASN B 63 21.119 10.855 47.564 1.00 16.63 O

ATOM 3344 N ASN B 64 22.345 8.956 47.391 1.00 15.84 N

ATOM 3345 CA ASN B 64 21.231 8.007 47.517 1.00 15.19 C

ATOM 3346 CB ASN B 64 20.575 8.112 48.902 1.00 15.31 C

ATOM 3347 CG ASN B 64 21.547 7.825 50.019 1.00 15.19 C

ATOM 3348 ODl ASN B 64 22.102 6.731 50.101 1.00 15.57 O

ATOM 3349 ND2 ASN B 64 21.764 8.807 50.886 1.00 14.71 N

ATOM 3350 C ASN B 64 20.186 8.089 46.400 1.00 14.77 C

ATOM 3351 O ASN B 64 19.061 7.617 46.556 1.00 14.47 O

ATOM 3352 N GLU B 65 20.567 8.684 45.275 1.00 14.23 N

ATOM 3353 CA GLU B 65 19.688 8.747 44.111 1.00 14.52 C

ATOM 3354 CB GLU B 65 19.340 10.198 43.774 1.00 14.33 C

ATOM 3355 CG GLU B 65 18.451 10.863 44.817 1.00 15.73 C

ATOM 3356 CD GLU B 65 18.046 12.278 44.452 1.00 16.02 C

ATOM 3357 OEl GLU B 65 17.010 12.749 44.989 1.00 19.02 O

ATOM 3358 OE2 GLU B 65 18.757 12.916 43.641 1.00 17.43 O

ATOM 3359 C GLU B 65 20.309 8.050 42.906 1.00 13.66 C

ATOM 3360 O GLU B 65 21.520 8.137 42.689 1.00 13.50 O

ATOM 3361 N ILE B 66 19.470 7.363 42.127 1.00 13.31 N

ATOM 3362 CA ILE B 66 19.917 6.677 40.907 1.00 12.58 C

ATOM 3363 CB ILE B 66 18.809 5.748 40.310 1.00 12.55 C

ATOM 3364 CGl ILE B 66 19.374 4.872 39.178 1.00 12.34 C

ATOM 3365 CDl ILE B 66 18.488 3.689 38.787 1.00 12.08 C

ATOM 3366 CG2 ILE B 66 17.566 6.552 39.886 1.00 11.54 C

ATOM 3367 C ILE B 66 20.431 7.687 39.872 1.00 12.66 C

ATOM 3368 O ILE B 66 19.915 8.799 39.775 1.00 12.57 O

ATOM 3369 N THR B 67 21.462 7.299 39.126 1.00 12.22 N

ATOM 3370 CA THR B 67 22.088 8.198 38.170 1.00 12.35 C

ATOM 3371 CB THR B 67 23.111 9.148 38.875 1.00 12.32 C

ATOM 3372 OGl THR B 67 23.411 10.256 38.021 1.00 14.01 O

ATOM 3373 CG2 THR B 67 24.398 8.422 39.229 1.00 12.85 C

ATOM 3374 C THR B 67 22.748 7.440 37.010 1.00 11.99 C

ATOM 3375 O THR B 67 22.925 6.213 37.068 1.00 11.71 O

ATOM 3376 N THR B 68 23.099 8.183 35.963 1.00 11.45 N

ATOM 3377 CA THR B 68 23.847 7.647 34.826 1.00 11.10 C

ATOM 3378 CB THR B 68 23.821 8.631 33.635 1.00 11.21 C

ATOM 3379 OGl THR B 68 24.355 9.899 34.046 1.00 9.67 O

ATOM 3380 CG2 THR B 68 22.391 8.820 33.110 1.00 10.38 C

ATOM 3381 C THR B 68 25.311 7.367 35.212 1.00 11.20 C W2025-7029WO / AM102903-PCT

ATOM 3382 O THR B 68 25.770 7.790 36.273 1.00 11.09 O

ATOM 3383 N ILE B 69 26.030 6.658 34.344 1.00 11.14 N

ATOM 3384 CA ILE B 69 27.454 6.374 34.539 1.00 11.50 C

ATOM 3385 CB ILE B 69 27.722 4.862 34.831 1.00 11.39 C

ATOM 3386 CGl ILE B 69 27.218 4.483 36.229 1.00 12.12 C

ATOM 3387 CDl ILE B 69 27.194 2.985 36.499 1.00 12.15 C

ATOM 3388 CG2 ILE B 69 29.216 4.533 34.723 1.00 12.53 C

ATOM 3389 C ILE B 69 28.259 6.841 33.322 1.00 11.20 C

ATOM 3390 O ILE B 69 29.239 7.573 33.461 1.00 11.32 O

ATOM 3391 N GLU B 70 27.839 6.419 32.132 1.00 10.92 N

ATOM 3392 CA GLU B 70 28.537 6.789 30.903 1.00 10.66 C

ATOM 3393 CB GLU B 70 28.379 5.703 29.830 1.00 10.75 C

ATOM 3394 CG GLU B 70 28.952 4.329 30.216 1.00 11.63 C

ATOM 3395 CD GLU B 70 30.447 4.347 30.553 1.00 12.84 C

ATOM 3396 OEl GLU B 70 30.856 3.592 31.458 1.00 13.91 O

ATOM 3397 OE2 GLU B 70 31.210 5.104 29.921 1.00 12.69 O

ATOM 3398 C GLU B 70 28.079 8.144 30.374 1.00 10.09 C

ATOM 3399 O GLU B 70 26.955 8.576 30.638 1.00 9.96 O

ATOM 3400 N TRP B 71 28.963 8.794 29.618 1.00 9.35 N

ATOM 3401 CA TRP B 71 28.751 10.155 29.114 1.00 9.01 C

ATOM 3402 CB TRP B 71 29.990 10.624 28.331 1.00 8.52 C

ATOM 3403 CG TRP B 71 30.120 9.960 26.984 1.00 8.73 C

ATOM 3404 CDl TRP B 71 30.646 8.722 26.725 1.00 8.19 C

ATOM 3405 NEl TRP B 71 30.581 8.454 25.377 1.00 8.00 N

ATOM 3406 CE2 TRP B 71 30.006 9.520 24.736 1.00 8.18 C

ATOM 3407 CD2 TRP B 71 29.705 10.493 25.717 1.00 8.18 C

ATOM 3408 CE3 TRP B 71 29.105 11.698 25.315 1.00 7.93 C

ATOM 3409 CZ3 TRP B 71 28.831 11.890 23.965 1.00 8.23 C

ATOM 3410 CH2 TRP B 71 29.146 10.901 23.010 1.00 8.16 C

ATOM 3411 CZ2 TRP B 71 29.728 9.713 23.375 1.00 8.31 C

ATOM 3412 C TRP B 71 27.492 10.325 28.250 1.00 8.71 C

ATOM 3413 O TRP B 71 26.907 11.408 28.210 1.00 8.59 O

ATOM 3414 N ASN B 72 27.091 9.260 27.557 1.00 8.40 N

ATOM 3415 CA ASN B 72 25.979 9.316 26.604 1.00 8.10 C

ATOM 3416 CB ASN B 72 26.467 8.938 25.200 1.00 7.89 C

ATOM 3417 CG ASN B 72 27.106 7.550 25.150 1.00 7.83 C

ATOM 3418 ODl ASN B 72 27.468 6.978 26.181 1.00 8.26 O

ATOM 3419 ND2 ASN B 72 27.256 7.009 23.942 1.00 7.56 N

ATOM 3420 C ASN B 72 24.801 8.423 26.989 1.00 7.94 C

ATOM 3421 O ASN B 72 23.988 8.071 26.137 1.00 7.87 O

ATOM 3422 N ASP B 73 24.727 8.048 28.265 1.00 7.76 N

ATOM 3423 CA ASP B 73 23.669 7.164 28.754 1.00 7.67 C

ATOM 3424 CB ASP B 73 23.804 6.923 30.264 1.00 7.59 C

ATOM 3425 CG ASP B 73 24.722 5.750 30.599 1.00 7.71 C

ATOM 3426 ODl ASP B 73 24.944 4.872 29.731 1.00 7.73 O

ATOM 3427 OD2 ASP B 73 25.209 5.699 31.748 1.00 8.80 O

ATOM 3428 C ASP B 73 22.253 7.633 28.411 1.00 7.53 C

ATOM 3429 O ASP B 73 21.417 6.828 28.018 1.00 7.20 O

ATOM 3430 N VAL B 74 21.992 8.930 28.552 1.00 8.01 N

ATOM 3431 CA VAL B 74 20.667 9.493 28.258 1.00 8.45 C

ATOM 3432 CB VAL B 74 20.607 11.018 28.582 1.00 8.47 C

ATOM 3433 CGl VAL B 74 19.373 11.666 27.960 1.00 8.95 C

ATOM 3434 CG2 VAL B 74 20.624 11.234 30.094 1.00 8.64 C

ATOM 3435 C VAL B 74 20.257 9.221 26.807 1.00 8.80 C

ATOM 3436 O VAL B 74 19.138 8.780 26.543 1.00 8.60 O

ATOM 3437 N THR B 75 21.184 9.466 25.884 1.00 8.84 N

ATOM 3438 CA THR B 75 20.972 9.216 24.461 1.00 9.59 C

ATOM 3439 CB THR B 75 22.160 9.782 23.632 1.00 9.76 C

ATOM 3440 OGl THR B 75 22.231 11.198 23.828 1.00 10.47 O

ATOM 3441 CG2 THR B 75 22.011 9.486 22.138 1.00 9.94 C

ATOM 3442 C THR B 75 20.769 7.721 24.199 1.00 9.47 C

ATOM 3443 O THR B 75 19.873 7.327 23.439 1.00 9.64 O

ATOM 3444 N LEU B 76 21.583 6.891 24.849 1.00 9.37 N W2025-7029WO / AM102903-PCT

ATOM 3445 CA LEU B 76 21.462 5.442 24.708 1.00 9.08 C

ATOM 3446 CB LEU B 76 22.663 4.710 25.314 1.00 9.28 C

ATOM 3447 CG LEU B 76 24.049 5.024 24.725 1.00 9.62 C

ATOM 3448 CDl LEU B 76 25.100 4.086 25.301 1.00 9.71 C

ATOM 3449 CD2 LEU B 76 24.072 4.996 23.200 1.00 10.02 C

ATOM 3450 C LEU B 76 20.154 4.907 25.286 1.00 8.95 C

ATOM 3451 O LEU B 76 19.535 4.034 24.674 1.00 8.51 O

ATOM 3452 N TYR B 77 19.734 5.438 26.439 1.00 8.74 N

ATOM 3453 CA TYR B 77 18.435 5.092 27.042 1.00 9.12 C

ATOM 3454 CB TYR B 77 18.088 5.994 28.242 1.00 8.78 C

ATOM 3455 CG TYR B 77 18.901 5.851 29.522 1.00 8.53 C

ATOM 3456 CDl TYR B 77 19.693 4.726 29.782 1.00 8.29 C

ATOM 3457 CEl TYR B 77 20.420 4.614 30.979 1.00 7.26 C

ATOM 3458 CZ TYR B 77 20.339 5.634 31.925 1.00 8.77 C

ATOM 3459 OH TYR B 77 21.036 5.568 33.112 1.00 8.81 O

ATOM 3460 CE2 TYR B 77 19.551 6.744 31.690 1.00 8.60 C

ATOM 3461 CD2 TYR B 77 18.837 6.845 30.499 1.00 8.69 C

ATOM 3462 C TYR B 77 17.325 5.244 26.004 1.00 9.49 C

ATOM 3463 O TYR B 77 16.491 4.354 25.838 1.00 9.41 O

ATOM 3464 N GLN B 78 17.331 6.386 25.315 1.00 10.25 N

ATOM 3465 CA GLN B 78 16.317 6.725 24.312 1.00 11.22 C

ATOM 3466 CB GLN B 78 16.558 8.139 23.753 1.00 11.23 C

ATOM 3467 CG GLN B 78 16.447 9.252 24.805 1.00 13.16 C

ATOM 3468 CD GLN B 78 16.799 10.646 24.271 1.00 13.88 C

ATOM 3469 OEl GLN B 78 17.523 10.796 23.275 1.00 18.84 O

ATOM 3470 NE2 GLN B 78 16.284 11.669 24.936 1.00 15.58 N

ATOM 3471 C GLN B 78 16.251 5.699 23.181 1.00 10.57 C

ATOM 3472 O GLN B 78 15.167 5.218 22.835 1.00 10.32 O

ATOM 3473 N ALA B 79 17.413 5.361 22.621 1.00 10.36 N

ATOM 3474 CA ALA B 79 17.514 4.368 21.553 1.00 10.14 C

ATOM 3475 CB ALA B 79 18.935 4.346 20.984 1.00 10.35 C

ATOM 3476 C ALA B 79 17.096 2.971 22.031 1.00 9.92 C

ATOM 3477 O ALA B 79 16.414 2.235 21.312 1.00 9.64 O

ATOM 3478 N PHE B 80 17.500 2.635 23.256 1.00 9.42 N

ATOM 3479 CA PHE B 80 17.245 1.333 23.879 1.00 9.22 C

ATOM 3480 CB PHE B 80 18.002 1.272 25.211 1.00 9.01 C

ATOM 3481 CG PHE B 80 18.024 -0.081 25.860 1.00 8.52 C

ATOM 3482 CDl PHE B 80 17.216 -0.348 26.964 1.00 8.51 C

ATOM 3483 CEl PHE B 80 17.249 -1.595 27.597 1.00 8.38 C

ATOM 3484 CZ PHE B 80 18.112 -2.582 27.130 1.00 8.72 C

ATOM 3485 CE2 PHE B 80 18.931 -2.324 26.033 1.00 8.58 C

ATOM 3486 CD2 PHE B 80 18.892 -1.075 25.409 1.00 8.06 C

ATOM 3487 C PHE B 80 15.751 1.119 24.115 1.00 9.29 C

ATOM 3488 O PHE B 80 15.206 0.054 23.808 1.00 9.28 O

ATOM 3489 N ASN B 81 15.093 2.136 24.664 1.00 9.13 N

ATOM 3490 CA ASN B 81 13.669 2.043 24.950 1.00 9.08 C

ATOM 3491 CB ASN B 81 13.293 2.973 26.103 1.00 8.95 C

ATOM 3492 CG ASN B 81 13.890 2.512 27.420 1.00 9.42 C

ATOM 3493 ODl ASN B 81 13.923 1.315 27.708 1.00 9.89 O

ATOM 3494 ND2 ASN B 81 14.384 3.449 28.215 1.00 9.41 N

ATOM 3495 C ASN B 81 12.813 2.244 23.700 1.00 8.99 C

ATOM 3496 O ASN B 81 11.712 1.703 23.601 1.00 8.96 O

ATOM 3497 N GLY B 82 13.362 2.971 22.729 1.00 9.04 N

ATOM 3498 CA GLY B 82 12.746 3.127 21.409 1.00 9.10 C

ATOM 3499 C GLY B 82 12.552 1.818 20.650 1.00 8.93 C

ATOM 3500 O GLY B 82 11.711 1.737 19.757 1.00 8.93 O

ATOM 3501 N LEU B 83 13.330 0.795 21.008 1.00 8.77 N

ATOM 3502 CA LEU B 83 13.200 -0.544 20.415 1.00 8.81 C

ATOM 3503 CB LEU B 83 14.274 -1.494 20.968 1.00 8.70 C

ATOM 3504 CG LEU B 83 15.744 -1.192 20.657 1.00 8.51 C

ATOM 3505 CDl LEU B 83 16.655 -2.006 21.567 1.00 7.35 C

ATOM 3506 CD2 LEU B 83 16.078 -1.430 19.175 1.00 7.72 C

ATOM 3507 C LEU B 83 11.807 -1.155 20.613 1.00 8.91 C W2025-7029WO / AM102903-PCT

ATOM 3508 O LEU B 83 11.380 -2.009 19.825 1.00 8.93 O

ATOM 3509 N LYS B 84 11.107 -0.707 21.658 1.00 8.81 N

ATOM 3510 CA LYS B 84 9.743 -1.162 21.956 1.00 9.00 C

ATOM 3511 CB LYS B 84 9.322 -0.721 23.360 1.00 8.81 C

ATOM 3512 CG LYS B 84 10.192 -1.288 24.479 1.00 7.87 C

ATOM 3513 CD LYS B 84 9.638 -0.928 25.851 1.00 8.50 C

ATOM 3514 CE LYS B 84 10.203 0.386 26.362 1.00 7.13 C

ATOM 3515 NZ LYS B 84 9.480 0.810 27.586 1.00 6.34 N

ATOM 3516 C LYS B 84 8.692 -0.728 20.920 1.00 9.63 C

ATOM 3517 O LYS B 84 7.584 -1.273 20.885 1.00 9.60 O

ATOM 3518 N ASN B 85 9.035 0.250 20.084 1.00 10.51 N

ATOM 3519 CA ASN B 85 8.157 0.661 18.978 1.00 11.37 C

ATOM 3520 CB ASN B 85 8.615 1.998 18.386 1.00 11.86 C

ATOM 3521 CG ASN B 85 8.479 3.150 19.363 1.00 13.46 C

ATOM 3522 ODl ASN B 85 7.515 3.226 20.135 1.00 15.02 O

ATOM 3523 ND2 ASN B 85 9.448 4.061 19.334 1.00 15.03 N

ATOM 3524 C ASN B 85 8.065 -0.391 17.871 1.00 11.55 C

ATOM 3525 O ASN B 85 7.121 -0.386 17.073 1.00 11.59 O

ATOM 3526 N LYS B 86 9.052 -1.285 17.834 1.00 11.39 N

ATOM 3527 CA LYS B 86 9.117 -2.356 16.840 1.00 11.69 C

ATOM 3528 CB LYS B 86 10.549 -2.490 16.297 1.00 11.83 C

ATOM 3529 CG LYS B 86 10.986 -1.300 15.438 1.00 13.26 C

ATOM 3530 CD LYS B 86 12.492 -1.258 15.238 1.00 15.56 C

ATOM 3531 CE LYS B 86 12.891 -0.160 14.254 1.00 17.64 C

ATOM 3532 NZ LYS B 86 14.351 0.182 14.344 1.00 19.19 N

ATOM 3533 C LYS B 86 8.601 -3.701 17.363 1.00 11.30 C

ATOM 3534 O LYS B 86 8.312 -4.606 16.578 1.00 11.21 O

ATOM 3535 N ASN B 87 8.485 -3.828 18.684 1.00 10.79 N

ATOM 3536 CA ASN B 87 7.915 -5.025 19.306 1.00 10.57 C

ATOM 3537 CB ASN B 87 9.010 -6.063 19.611 1.00 10.40 C

ATOM 3538 CG ASN B 87 8.464 -7.345 20.244 1.00 10.57 C

ATOM 3539 ODl ASN B 87 7.252 -7.595 20.258 1.00 10.25 O

ATOM 3540 ND2 ASN B 87 9.366 -8.168 20.763 1.00 9.90 N

ATOM 3541 C ASN B 87 7.147 -4.651 20.570 1.00 10.39 C

ATOM 3542 O ASN B 87 7.749 -4.375 21.607 1.00 10.23 O

ATOM 3543 N SER B 88 5.818 -4.643 20.470 1.00 10.01 N

ATOM 3544 CA SER B 88 4.947 -4.244 21.581 1.00 9.60 C

ATOM 3545 CB SER B 88 3.492 -4.212 21.131 1.00 9.61 C

ATOM 3546 OG SER B 88 2.939 -5.512 21.149 1.00 9.05 O

ATOM 3547 C SER B 88 5.067 -5.122 22.834 1.00 9.46 C

ATOM 3548 O SER B 88 4.744 -4.677 23.939 1.00 9.36 O

ATOM 3549 N GLN B 89 5.507 -6.367 22.654 1.00 9.25 N

ATOM 3550 CA GLN B 89 5.638 -7.315 23.759 1.00 9.49 C

ATOM 3551 CB GLN B 89 5.645 -8.746 23.223 1.00 9.51 C

ATOM 3552 CG GLN B 89 5.379 -9.821 24.264 1.00 10.22 C

ATOM 3553 CD GLN B 89 5.557 -11.217 23.706 1.00 10.21 C

ATOM 3554 OEl GLN B 89 6.661 -11.769 23.724 1.00 12.05 O

ATOM 3555 NE2 GLN B 89 4.465 -11.802 23.210 1.00 9.47 N

ATOM 3556 C GLN B 89 6.906 -7.055 24.588 1.00 9.30 C

ATOM 3557 O GLN B 89 7.007 -7.480 25.741 1.00 8.89 O

ATOM 3558 N LEU B 90 7.860 -6.346 23.990 1.00 9.10 N

ATOM 3559 CA LEU B 90 9.157 -6.095 24.610 1.00 8.98 C

ATOM 3560 CB LEU B 90 10.121 -5.533 23.560 1.00 8.92 C

ATOM 3561 CG LEU B 90 11.582 -5.266 23.914 1.00 9.34 C

ATOM 3562 CDl LEU B 90 12.315 -6.559 24.244 1.00 9.84 C

ATOM 3563 CD2 LEU B 90 12.253 -4.540 22.764 1.00 8.77 C

ATOM 3564 C LEU B 90 9.057 -5.150 25.807 1.00 8.97 C

ATOM 3565 O LEU B 90 8.396 -4.114 25.734 1.00 9.13 O

ATOM 3566 N LYS B 91 9.708 -5.524 26.908 1.00 8.94 N

ATOM 3567 CA LYS B 91 9.818 -4.666 28.088 1.00 8.96 C

ATOM 3568 CB LYS B 91 9.083 -5.257 29.308 1.00 9.07 C

ATOM 3569 CG LYS B 91 7.590 -5.574 29.130 1.00 9.78 C

ATOM 3570 CD LYS B 91 6.748 -4.373 28.685 1.00 11.62 C W2025-7029WO / AM102903-PCT

ATOM 3571 CE LYS B 91 5.477 -4.850 27.976 1.00 12.16 C

ATOM 3572 NZ LYS B 91 4.766 -3.781 27.216 1.00 13.25 N

ATOM 3573 C LYS B 91 11.290 -4.457 28.431 1.00 8.79 C

ATOM 3574 O LYS B 91 12.123 -5.330 28.182 1.00 8.96 O

ATOM 3575 N THR B 92 11.602 -3.305 29.019 1.00 8.26 N

ATOM 3576 CA THR B 92 12.982 -2.971 29.358 1.00 7.76 C

ATOM 3577 CB THR B 92 13.498 -1.733 28.582 1.00 7.65 C

ATOM 3578 OGl THR B 92 12.714 -0.584 28.928 1.00 8.08 O

ATOM 3579 CG2 THR B 92 13.441 -1.958 27.075 1.00 6.99 C

ATOM 3580 C THR B 92 13.149 -2.710 30.844 1.00 7.55 C

ATOM 3581 O THR B 92 12.224 -2.261 31.522 1.00 7.59 O

ATOM 3582 N LEU B 93 14.338 -3.000 31.352 1.00 7.05 N

ATOM 3583 CA LEU B 93 14.669 -2.670 32.727 1.00 6.98 C

ATOM 3584 CB LEU B 93 14.621 -3.913 33.633 1.00 7.05 C

ATOM 3585 CG LEU B 93 13.297 -4.682 33.772 1.00 7.58 C

ATOM 3586 CDl LEU B 93 13.200 -5.822 32.749 1.00 9.03 C

ATOM 3587 CD2 LEU B 93 13.125 -5.232 35.179 1.00 9.01 C

ATOM 3588 C LEU B 93 16.045 -2.017 32.759 1.00 6.76 C

ATOM 3589 O LEU B 93 16.872 -2.229 31.863 1.00 6.66 O

ATOM 3590 N LEU B 94 16.266 -1.196 33.778 1.00 6.45 N

ATOM 3591 CA LEU B 94 17.565 -0.593 34.019 1.00 5.79 C

ATOM 3592 CB LEU B 94 17.399 0.904 34.287 1.00 5.49 C

ATOM 3593 CG LEU B 94 18.618 1.764 34.642 1.00 5.38 C

ATOM 3594 CDl LEU B 94 19.674 1.760 33.538 1.00 4.36 C

ATOM 3595 CD2 LEU B 94 18.147 3.179 34.936 1.00 5.33 C

ATOM 3596 C LEU B 94 18.226 -1.296 35.202 1.00 5.86 C

ATOM 3597 O LEU B 94 17.623 -1.417 36.273 1.00 5.57 O

ATOM 3598 N ALA B 95 19.451 -1.778 34.997 1.00 5.96 N

ATOM 3599 CA ALA B 95 20.191 -2.453 36.066 1.00 6.50 C

ATOM 3600 CB ALA B 95 21.002 -3.628 35.522 1.00 6.28 C

ATOM 3601 C ALA B 95 21.086 -1.481 36.822 1.00 6.93 C

ATOM 3602 O ALA B 95 21.857 -0.738 36.214 1.00 7.16 O

ATOM 3603 N ILE B 96 20.966 -1.476 38.150 1.00 7.48 N

ATOM 3604 CA ILE B 96 21.832 -0.651 38.995 1.00 7.92 C

ATOM 3605 CB ILE B 96 21.029 0.243 40.005 1.00 7.72 C

ATOM 3606 CGl ILE B 96 21.988 1.157 40.791 1.00 7.62 C

ATOM 3607 CDl ILE B 96 21.317 2.201 41.659 1.00 7.87 C

ATOM 3608 CG2 ILE B 96 20.119 -0.605 40.928 1.00 6.89 C

ATOM 3609 C ILE B 96 22.870 -1.510 39.722 1.00 8.71 C

ATOM 3610 O ILE B 96 22.548 -2.574 40.252 1.00 8.84 O

ATOM 3611 N GLY B 97 24.115 -1.045 39.729 1.00 9.43 N

ATOM 3612 CA GLY B 97 25.174 -1.698 40.484 1.00 10.52 C

ATOM 3613 C GLY B 97 26.257 -2.271 39.597 1.00 11.16 C

ATOM 3614 O GLY B 97 26.857 -1.557 38.790 1.00 11.33 O

ATOM 3615 N GLY B 98 26.509 -3.566 39.754 1.00 11.83 N

ATOM 3616 CA GLY B 98 27.571 -4.239 39.017 1.00 12.53 C

ATOM 3617 C GLY B 98 28.802 -4.487 39.862 1.00 13.20 C

ATOM 3618 O GLY B 98 28.841 -4.139 41.048 1.00 12.95 O

ATOM 3619 N TRP B 99 29.818 -5.070 39.233 1.00 14.34 N

ATOM 3620 CA TRP B 99 31.018 -5.526 39.932 1.00 15.53 C

ATOM 3621 CB TRP B 99 31.823 -6.479 39.041 1.00 16.39 C

ATOM 3622 CG TRP B 99 32.932 -7.208 39.745 1.00 17.51 C

ATOM 3623 CDl TRP B 99 34.272 -7.011 39.581 1.00 18.38 C

ATOM 3624 NEl TRP B 99 34.982 -7.870 40.384 1.00 18.33 N

ATOM 3625 CE2 TRP B 99 34.103 -8.652 41.085 1.00 18.43 C

ATOM 3626 CD2 TRP B 99 32.798 -8.261 40.710 1.00 18.63 C

ATOM 3627 CE3 TRP B 99 31.701 -8.918 41.290 1.00 19.11 C

ATOM 3628 CZ3 TRP B 99 31.942 -9.931 42.224 1.00 18.63 C

ATOM 3629 CH2 TRP B 99 33.255 -10.290 42.580 1.00 18.50 C

ATOM 3630 CZ2 TRP B 99 34.345 -9.665 42.022 1.00 18.75 C

ATOM 3631 C TRP B 99 31.883 -4.382 40.449 1.00 15.64 C

ATOM 3632 O TRP B 99 32.188 -4.331 41.634 1.00 15.71 O

ATOM 3633 N ASN B 100 32.257 -3.462 39.567 1.00 15.81 N W2025-7029WO / AM102903-PCT

ATOM 3634 CA ASN B 100 33.077 -2.320 39.954 1.00 16.22 C

ATOM 3635 CB ASN B 100 33.537 -1.551 38.717 1.00 16.46 C

ATOM 3636 CG ASN B 100 34.584 -2.306 37.921 1.00 17.60 C

ATOM 3637 ODl ASN B 100 35.225 -3.237 38.428 1.00 19.28 O

ATOM 3638 ND2 ASN B 100 34.768 -1.909 36.669 1.00 18.74 N

ATOM 3639 C ASN B 100 32.383 -1.386 40.947 1.00 16.13 C

ATOM 3640 O ASN B 100 33.038 -0.788 41.803 1.00 16.12 O

ATOM 3641 N PHE B 101 31.060 -1.283 40.829 1.00 15.84 N

ATOM 3642 CA PHE B 101 30.242 -0.464 41.725 1.00 15.86 C

ATOM 3643 CB PHE B 101 28.760 -0.592 41.355 1.00 15.64 C

ATOM 3644 CG PHE B 101 27.875 0.443 41.993 1.00 15.21 C

ATOM 3645 CDl PHE B 101 27.793 1.729 41.465 1.00 14.98 C

ATOM 3646 CEl PHE B 101 26.972 2.690 42.050 1.00 14.66 C

ATOM 3647 CZ PHE B 101 26.206 2.362 43.168 1.00 14.91 C

ATOM 3648 CE2 PHE B 101 26.277 1.078 43.701 1.00 14.85 C

ATOM 3649 CD2 PHE B 101 27.108 0.127 43.112 1.00 14.56 C

ATOM 3650 C PHE B 101 30.465 -0.840 43.190 1.00 16.02 C

ATOM 3651 O PHE B 101 30.576 0.037 44.051 1.00 16.10 O

ATOM 3652 N GLY B 102 30.546 -2.140 43.460 1.00 16.28 N

ATOM 3653 CA GLY B 102 30.766 -2.637 44.813 1.00 16.60 C

ATOM 3654 C GLY B 102 29.517 -2.540 45.670 1.00 16.84 C

ATOM 3655 O GLY B 102 28.398 -2.480 45.154 1.00 16.96 O

ATOM 3656 N THR B 103 29.713 -2.496 46.985 1.00 17.08 N

ATOM 3657 CA THR B 103 28.608 -2.597 47.934 1.00 17.29 C

ATOM 3658 CB THR B 103 28.864 -3.706 48.975 1.00 17.55 C

ATOM 3659 OGl THR B 103 30.055 -3.400 49.714 1.00 18.05 O

ATOM 3660 CG2 THR B 103 29.035 -5.054 48.286 1.00 17.95 C

ATOM 3661 C THR B 103 28.318 -1.301 48.682 1.00 17.00 C

ATOM 3662 O THR B 103 27.178 -1.066 49.084 1.00 17.20 O

ATOM 3663 N ALA B 104 29.347 -0.469 48.860 1.00 16.50 N

ATOM 3664 CA ALA B 104 29.288 0.702 49.750 1.00 15.89 C

ATOM 3665 CB ALA B 104 30.614 1.484 49.720 1.00 15.84 C

ATOM 3666 C ALA B 104 28.082 1.644 49.570 1.00 15.57 C

ATOM 3667 O ALA B 104 27.440 1.999 50.565 1.00 15.63 O

ATOM 3668 N PRO B 105 27.769 2.060 48.319 1.00 15.15 N

ATOM 3669 CA PRO B 105 26.608 2.940 48.144 1.00 14.60 C

ATOM 3670 CB PRO B 105 26.675 3.330 46.658 1.00 14.69 C

ATOM 3671 CG PRO B 105 28.085 3.020 46.239 1.00 14.82 C

ATOM 3672 CD PRO B 105 28.432 1.800 47.027 1.00 15.14 C

ATOM 3673 C PRO B 105 25.263 2.280 48.470 1.00 14.03 C

ATOM 3674 O PRO B 105 24.352 2.962 48.940 1.00 13.96 O

ATOM 3675 N PHE B 106 25.139 0.976 48.225 1.00 13.48 N

ATOM 3676 CA PHE B 106 23.926 0.239 48.600 1.00 12.80 C

ATOM 3677 CB PHE B 106 23.936 -1.180 48.029 1.00 12.39 C

ATOM 3678 CG PHE B 106 23.637 -1.271 46.552 1.00 12.19 C

ATOM 3679 CDl PHE B 106 22.357 -1.020 46.061 1.00 11.67 C

ATOM 3680 CEl PHE B 106 22.078 -1.134 44.694 1.00 11.99 C

ATOM 3681 CZ PHE B 106 23.085 -1.516 43.804 1.00 10.83 C

ATOM 3682 CE2 PHE B 106 24.361 -1.779 44.285 1.00 11.05 C

ATOM 3683 CD2 PHE B 106 24.631 -1.662 45.652 1.00 11.73 C

ATOM 3684 C PHE B 106 23.790 0.166 50.128 1.00 12.73 C

ATOM 3685 O PHE B 106 22.711 0.402 50.679 1.00 12.14 O

ATOM 3686 N THR B 107 24.900 -0.167 50.792 1.00 12.61 N

ATOM 3687 CA THR B 107 24.971 -0.260 52.255 1.00 12.58 C

ATOM 3688 CB THR B 107 26.405 -0.665 52.708 1.00 12.59 C

ATOM 3689 OGl THR B 107 26.657 -2.023 52.318 1.00 12.63 O

ATOM 3690 CG2 THR B 107 26.571 -0.550 54.222 1.00 13.06 C

ATOM 3691 C THR B 107 24.506 1.039 52.930 1.00 12.53 C

ATOM 3692 O THR B 107 23.694 1.012 53.867 1.00 12.30 O

ATOM 3693 N ALA B 108 25.012 2.163 52.433 1.00 12.24 N

ATOM 3694 CA ALA B 108 24.629 3.484 52.920 1.00 12.63 C

ATOM 3695 CB ALA B 108 25.529 4.547 52.315 1.00 12.57 C

ATOM 3696 C ALA B 108 23.160 3.804 52.636 1.00 12.87 C W2025-7029WO / AM102903-PCT

ATOM 3697 O ALA B 108 22.475 4.405 53.468 1.00 12.93 O

ATOM 3698 N MET B 109 22.679 3.387 51.466 1.00 13.06 N

ATOM 3699 CA MET B 109 21.312 3.686 51.035 1.00 13.21 C

ATOM 3700 CB MET B 109 21.174 3.457 49.525 1.00 13.17 C

ATOM 3701 CG MET B 109 19.814 3.804 48.932 1.00 12.73 C

ATOM 3702 SD MET B 109 18.690 2.393 48.948 1.00 12.61

ATOM 3703 CE MET B 109 19.425 1.357 47.684 1.00 10.98 C

ATOM 3704 C MET B 109 20.237 2.924 51.823 1.00 13.58 C

ATOM 3705 O MET B 109 19.161 3.460 52.084 1.00 13.78 O

ATOM 3706 N VAL B 110 20.524 1.685 52.207 1.00 13.79 N

ATOM 3707 CA VAL B 110 19.524 0.864 52.896 1.00 14.24 C

ATOM 3708 CB VAL B 110 19.665 -0.650 52.557 1.00 14.34 C

ATOM 3709 CGl VAL B 110 19.451 -0.895 51.056 1.00 13.90 C

ATOM 3710 CG2 VAL B 110 21.020 -1.206 53.026 1.00 13.82 C

ATOM 3711 C VAL B 110 19.527 1.073 54.416 1.00 14.65 C

ATOM 3712 O VAL B 110 18.623 0.603 55.115 1.00 14.60 O

ATOM 3713 N SER B 111 20.534 1.798 54.901 1.00 15.15 N

ATOM 3714 CA SER B 111 20.767 2.006 56.335 1.00 15.83 C

ATOM 3715 CB SER B 111 22.079 2.766 56.567 1.00 15.60 C

ATOM 3716 OG SER B 111 22.021 4.080 56.049 1.00 15.93 O

ATOM 3717 C SER B 111 19.609 2.671 57.093 1.00 16.18 C

ATOM 3718 O SER B 111 19.338 2.316 58.246 1.00 16.65 O

ATOM 3719 N THR B 112 18.931 3.624 56.451 1.00 16.26 N

ATOM 3720 CA THR B 112 17.805 4.332 57.073 1.00 16.10 C

ATOM 3721 CB THR B 112 18.155 5.821 57.401 1.00 16.27 C

ATOM 3722 OGl THR B 112 18.217 6.590 56.194 1.00 16.27 O

ATOM 3723 CG2 THR B 112 19.480 5.937 58.150 1.00 16.02 C

ATOM 3724 C THR B 112 16.548 4.300 56.193 1.00 16.15 C

ATOM 3725 O THR B 112 16.658 4.261 54.964 1.00 15.85 O

ATOM 3726 N PRO B 113 15.346 4.326 56.813 1.00 16.20 N

ATOM 3727 CA PRO B 113 14.112 4.417 56.021 1.00 16.19 C

ATOM 3728 CB PRO B 113 13.011 4.541 57.084 1.00 16.25 C

ATOM 3729 CG PRO B 113 13.601 3.991 58.329 1.00 16.06 C

ATOM 3730 CD PRO B 113 15.068 4.270 58.263 1.00 16.36 C

ATOM 3731 C PRO B 113 14.101 5.655 55.123 1.00 16.20 C

ATOM 3732 O PRO B 113 13.488 5.638 54.054 1.00 16.00 O

ATOM 3733 N GLU B 114 14.786 6.708 55.569 1.00 16.21 N

ATOM 3734 CA GLU B 114 14.855 7.984 54.854 1.00 16.77 C

ATOM 3735 CB GLU B 114 15.429 9.080 55.761 1.00 17.03 C

ATOM 3736 CG GLU B 114 14.544 9.428 56.968 1.00 19.77 C

ATOM 3737 CD GLU B 114 14.712 8.471 58.153 1.00 23.06 C

ATOM 3738 OEl GLU B 114 15.868 8.158 58.522 1.00 24.61 O

ATOM 3739 OE2 GLU B 114 13.683 8.049 58.733 1.00 25.18 O

ATOM 3740 C GLU B 114 15.663 7.880 53.559 1.00 16.31 C

ATOM 3741 O GLU B 114 15.239 8.394 52.519 1.00 16.39 O

ATOM 3742 N ASN B 115 16.816 7.213 53.632 1.00 15.76 N

ATOM 3743 CA ASN B 115 17.666 6.977 52.462 1.00 15.57 C

ATOM 3744 CB ASN B 115 19.028 6.402 52.878 1.00 15.30 C

ATOM 3745 CG ASN B 115 19.933 7.432 53.528 1.00 15.94 C

ATOM 3746 ODl ASN B 115 19.619 8.623 53.576 1.00 15.85 O

ATOM 3747 ND2 ASN B 115 21.074 6.971 54.036 1.00 16.84 N

ATOM 3748 C ASN B 115 17.003 6.057 51.433 1.00 15.16 C

ATOM 3749 O ASN B 115 17.168 6.251 50.230 1.00 15.44 O

ATOM 3750 N ARG B 116 16.262 5.060 51.914 1.00 14.61 N

ATOM 3751 CA ARG B 116 15.535 4.149 51.033 1.00 14.16 C

ATOM 3752 CB ARG B 116 14.992 2.942 51.808 1.00 14.02 C

ATOM 3753 CG ARG B 116 16.081 2.062 52.422 1.00 13.92 C

ATOM 3754 CD ARG B 116 15.561 0.709 52.889 1.00 14.00 C

ATOM 3755 NE ARG B 116 14.444 0.823 53.830 1.00 14.44 N

ATOM 3756 CZ ARG B 116 14.564 0.856 55.156 1.00 14.38 C

ATOM 3757 NHl ARG B 116 15.763 0.787 55.730 1.00 13.46 N

ATOM 3758 NH2 ARG B 116 13.476 0.959 55.912 1.00 13.36 N

ATOM 3759 C ARG B 116 14.414 4.876 50.279 1.00 13.95 C W2025-7029WO / AM102903-PCT

ATOM 3760 O ARG B 116 14.219 4.647 49.083 1.00 13.65 O

ATOM 3761 N GLN B 117 13.699 5.762 50.973 1.00 13.55 N

ATOM 3762 CA GLN B 117 12.627 6.544 50.352 1.00 13.26 C

ATOM 3763 CB GLN B 117 11.806 7.290 51.414 1.00 13.58 C

ATOM 3764 CG GLN B 117 10.774 6.418 52.121 1.00 14.40 C

ATOM 3765 CD GLN B 117 9.747 5.817 51.170 1.00 16.08 C

ATOM 3766 OEl GLN B 117 9.255 6.483 50.256 1.00 17.32 O

ATOM 3767 NE2 GLN B 117 9.417 4.548 51.385 1.00 17.91 N

ATOM 3768 C GLN B 117 13.153 7.514 49.301 1.00 12.79 C

ATOM 3769 O GLN B 117 12.538 7.700 48.248 1.00 12.82 O

ATOM 3770 N THR B 118 14.286 8.138 49.611 1.00 12.11 N

ATOM 3771 CA THR B 118 14.997 9.013 48.688 1.00 11.33 C

ATOM 3772 CB THR B 118 16.265 9.587 49.368 1.00 11.45 C

ATOM 3773 OGl THR B 118 15.868 10.473 50.426 1.00 11.32 O

ATOM 3774 CG2 THR B 118 17.148 10.348 48.372 1.00 11.14 C

ATOM 3775 C THR B 118 15.348 8.266 47.396 1.00 10.93 C

ATOM 3776 O THR B 118 15.101 8.770 46.297 1.00 10.94 O

ATOM 3777 N PHE B 119 15.906 7.064 47.547 1.00 10.16 N

ATOM 3778 CA PHE B 119 16.273 6.200 46.422 1.00 9.52 C

ATOM 3779 CB PHE B 119 17.098 5.010 46.923 1.00 9.41 C

ATOM 3780 CG PHE B 119 17.524 4.057 45.838 1.00 8.71 C

ATOM 3781 CDl PHE B 119 18.549 4.399 44.954 1.00 8.49 C

ATOM 3782 CEl PHE B 119 18.944 3.524 43.953 1.00 7.83 C

ATOM 3783 CZ PHE B 119 18.313 2.285 43.826 1.00 8.61 C

ATOM 3784 CE2 PHE B 119 17.288 1.934 44.704 1.00 7.87 C

ATOM 3785 CD2 PHE B 119 16.898 2.820 45.699 1.00 7.68 C

ATOM 3786 C PHE B 119 15.065 5.711 45.616 1.00 9.37 C

ATOM 3787 O PHE B 119 15.029 5.857 44.395 1.00 8.90 O

ATOM 3788 N ILE B 120 14.079 5.148 46.312 1.00 9.15 N

ATOM 3789 CA ILE B 120 12.866 4.636 45.677 1.00 9.01 C

ATOM 3790 CB ILE B 120 11.905 3.996 46.719 1.00 9.03 C

ATOM 3791 CGl ILE B 120 12.532 2.712 47.287 1.00 8.82 C

ATOM 3792 CDl ILE B 120 11.917 2.216 48.590 1.00 8.85 C

ATOM 3793 CG2 ILE B 120 10.547 3.680 46.084 1.00 8.63 C

ATOM 3794 C ILE B 120 12.170 5.717 44.846 1.00 9.10 C

ATOM 3795 O ILE B 120 11.789 5.476 43.701 1.00 9.28 O

ATOM 3796 N THR B 121 12.036 6.908 45.425 1.00 9.11 N

ATOM 3797 CA THR B 121 11.436 8.056 44.746 1.00 9.21 C

ATOM 3798 CB THR B 121 11.281 9.251 45.716 1.00 9.30 C

ATOM 3799 OGl THR B 121 10.525 8.834 46.862 1.00 11.08 O

ATOM 3800 CG2 THR B 121 10.566 10.413 45.049 1.00 9.79 C

ATOM 3801 C THR B 121 12.234 8.463 43.499 1.00 8.76 C

ATOM 3802 O THR B 121 11.650 8.698 42.440 1.00 8.34 O

ATOM 3803 N SER B 122 13.561 8.536 43.626 1.00 8.46 N

ATOM 3804 CA SER B 122 14.431 8.841 42.481 1.00 8.36 C

ATOM 3805 CB SER B 122 15.896 8.970 42.916 1.00 8.32 C

ATOM 3806 OG SER B 122 16.488 7.705 43.181 1.00 8.38 O

ATOM 3807 C SER B 122 14.298 7.804 41.359 1.00 8.43 C

ATOM 3808 O SER B 122 14.300 8.156 40.179 1.00 8.47 O

ATOM 3809 N VAL B 123 14.179 6.533 41.739 1.00 8.57 N

ATOM 3810 CA VAL B 123 14.042 5.433 40.778 1.00 8.53 C

ATOM 3811 CB VAL B 123 14.136 4.034 41.477 1.00 8.65 C

ATOM 3812 CGl VAL B 123 13.621 2.930 40.572 1.00 8.02 C

ATOM 3813 CG2 VAL B 123 15.573 3.735 41.907 1.00 8.20 C

ATOM 3814 C VAL B 123 12.758 5.575 39.939 1.00 8.68 C

ATOM 3815 O VAL B 123 12.820 5.550 38.710 1.00 8.76 O

ATOM 3816 N ILE B 124 11.611 5.739 40.602 1.00 8.72 N

ATOM 3817 CA ILE B 124 10.329 5.961 39.914 1.00 8.81 C

ATOM 3818 CB ILE B 124 9.169 6.226 40.914 1.00 8.72 C

ATOM 3819 CGl ILE B 124 8.919 4.991 41.783 1.00 9.16 C

ATOM 3820 CDl ILE B 124 7.973 5.214 42.959 1.00 9.17 C

ATOM 3821 CG2 ILE B 124 7.892 6.621 40.167 1.00 8.45 C

ATOM 3822 C ILE B 124 10.402 7.113 38.906 1.00 8.88 C W2025-7029WO / AM102903-PCT

ATOM 3823 O ILE B 124 9.973 6.966 37.758 1.00 8.50 O

ATOM 3824 N LYS B 125 10.938 8.252 39.349 1.00 9.03 N

ATOM 3825 CA LYS B 125 11.121 9.423 38.494 1.00 9.57 C

ATOM 3826 CB LYS B 125 11.695 10.592 39.305 1.00 9.69 C

ATOM 3827 CG LYS B 125 11.804 11.898 38.517 1.00 10.49 C

ATOM 3828 CD LYS B 125 12.378 13.028 39.367 1.00 11.13 C

ATOM 3829 CE LYS B 125 12.488 14.316 38.557 1.00 13.89 C

ATOM 3830 NZ LYS B 125 13.219 15.385 39.301 1.00 16.35 N

ATOM 3831 C LYS B 125 12.029 9.114 37.298 1.00 9.15 C

ATOM 3832 O LYS B 125 11.675 9.406 36.156 1.00 8.94 O

ATOM 3833 N PHE B 126 13.186 8.512 37.580 1.00 8.88 N

ATOM 3834 CA PHE B 126 14.197 8.164 36.575 1.00 8.50 C

ATOM 3835 CB PHE B 126 15.402 7.545 37.284 1.00 8.60 C

ATOM 3836 CG PHE B 126 16.720 7.714 36.565 1.00 8.72 C

ATOM 3837 CDl PHE B 126 17.197 6.720 35.717 1.00 8.74 C

ATOM 3838 CEl PHE B 126 18.437 6.851 35.085 1.00 8.72 C

ATOM 3839 CZ PHE B 126 19.219 7.982 35.314 1.00 8.98 C

ATOM 3840 CE2 PHE B 126 18.758 8.971 36.174 1.00 9.27 C

ATOM 3841 CD2 PHE B 126 17.519 8.830 36.800 1.00 8.42 C

ATOM 3842 C PHE B 126 13.658 7.197 35.510 1.00 8.34 C

ATOM 3843 O PHE B 126 13.820 7.441 34.308 1.00 8.24 O

ATOM 3844 N LEU B 127 13.008 6.115 35.947 1.00 8.08 N

ATOM 3845 CA LEU B 127 12.482 5.103 35.018 1.00 7.94 C

ATOM 3846 CB LEU B 127 12.027 3.830 35.750 1.00 7.78 C

ATOM 3847 CG LEU B 127 13.046 3.031 36.576 1.00 7.58 C

ATOM 3848 CDl LEU B 127 12.359 1.861 37.259 1.00 6.93 C

ATOM 3849 CD2 LEU B 127 14.241 2.554 35.745 1.00 6.90 C

ATOM 3850 C LEU B 127 11.352 5.639 34.137 1.00 8.12 C

ATOM 3851 O LEU B 127 11.317 5.355 32.935 1.00 7.69 O

ATOM 3852 N ARG B 128 10.431 6.400 34.733 1.00 8.12 N

ATOM 3853 CA ARG B 128 9.334 7.003 33.970 1.00 8.57 C

ATOM 3854 CB ARG B 128 8.245 7.574 34.899 1.00 8.63 C

ATOM 3855 CG ARG B 128 7.445 6.530 35.713 1.00 8.34 C

ATOM 3856 CD ARG B 128 6.740 5.486 34.829 1.00 8.62 C

ATOM 3857 NE ARG B 128 5.777 4.674 35.580 1.00 7.57 N

ATOM 3858 CZ ARG B 128 5.180 3.574 35.117 1.00 7.75 C

ATOM 3859 NHl ARG B 128 5.442 3.118 33.892 1.00 6.21 N

ATOM 3860 NH2 ARG B 128 4.318 2.918 35.889 1.00 6.66 N

ATOM 3861 C ARG B 128 9.842 8.084 33.007 1.00 8.88 C

ATOM 3862 O ARG B 128 9.369 8.183 31.879 1.00 8.69 O

ATOM 3863 N GLN B 129 10.801 8.887 33.465 1.00 9.25 N

ATOM 3864 CA GLN B 129 11.405 9.934 32.644 1.00 10.36 C

ATOM 3865 CB GLN B 129 12.462 10.692 33.456 1.00 10.27 C

ATOM 3866 CG GLN B 129 13.156 11.829 32.733 1.00 11.99 C

ATOM 3867 CD GLN B 129 14.243 12.477 33.575 1.00 12.02 C

ATOM 3868 OEl GLN B 129 14.365 12.212 34.775 1.00 14.86 O

ATOM 3869 NE2 GLN B 129 15.036 13.337 32.950 1.00 14.30 N

ATOM 3870 C GLN B 129 12.026 9.361 31.367 1.00 10.07 C

ATOM 3871 O GLN B 129 11.803 9.883 30.277 1.00 9.83 O

ATOM 3872 N TYR B 130 12.791 8.280 31.513 1.00 10.15 N

ATOM 3873 CA TYR B 130 13.529 7.701 30.386 1.00 10.44 C

ATOM 3874 CB TYR B 130 14.964 7.355 30.802 1.00 10.71 C

ATOM 3875 CG TYR B 130 15.739 8.553 31.300 1.00 11.19 C

ATOM 3876 CDl TYR B 130 16.007 9.636 30.458 1.00 10.97 C

ATOM 3877 CEl TYR B 130 16.715 10.738 30.914 1.00 11.82 C

ATOM 3878 CZ TYR B 130 17.171 10.762 32.228 1.00 11.62 C

ATOM 3879 OH TYR B 130 17.874 11.851 32.690 1.00 12.56 O

ATOM 3880 CE2 TYR B 130 16.921 9.703 33.079 1.00 11.56 C

ATOM 3881 CD2 TYR B 130 16.207 8.604 32.612 1.00 11.44 C

ATOM 3882 C TYR B 130 12.833 6.519 29.700 1.00 10.20 C

ATOM 3883 O TYR B 130 13.361 5.962 28.737 1.00 10.11 O

ATOM 3884 N GLU B 131 11.651 6.157 30.201 1.00 10.27 N

ATOM 3885 CA GLU B 131 10.764 5.145 29.584 1.00 10.46 C W2025-7029WO / AM102903-PCT

ATOM 3886 CB GLU B 131 10.409 5.515 28.124 1.00 10.35 C

ATOM 3887 CG GLU B 131 9.578 6.801 27.992 1.00 11.88 C

ATOM 3888 CD GLU B 131 9.423 7.311 26.553 1.00 12.61 C

ATOM 3889 OEl GLU B 131 9.195 8.529 26.384 1.00 15.72 O

ATOM 3890 OE2 GLU B 131 9.525 6.517 25.589 1.00 15.58 O

ATOM 3891 C GLU B 131 11.251 3.684 29.720 1.00 9.63 C

ATOM 3892 O GLU B 131 11.146 2.887 28.782 1.00 9.27 O

ATOM 3893 N PHE B 132 11.776 3.351 30.900 1.00 9.00 N

ATOM 3894 CA PHE B 132 12.074 1.969 31.275 1.00 8.53 C

ATOM 3895 CB PHE B 132 13.259 1.921 32.248 1.00 8.44 C

ATOM 3896 CG PHE B 132 14.607 2.098 31.591 1.00 8.07 C

ATOM 3897 CDl PHE B 132 15.239 1.025 30.964 1.00 7.69 C

ATOM 3898 CEl PHE B 132 16.489 1.182 30.364 1.00 8.87 C

ATOM 3899 CZ PHE B 132 17.123 2.428 30.398 1.00 8.73 C

ATOM 3900 CE2 PHE B 132 16.505 3.502 31.028 1.00 8.06 C

ATOM 3901 CD2 PHE B 132 15.255 3.331 31.626 1.00 8.81 C

ATOM 3902 C PHE B 132 10.845 1.344 31.940 1.00 8.40 C

ATOM 3903 O PHE B 132 10.004 2.061 32.492 1.00 8.31 O

ATOM 3904 N ASP B 133 10.752 0.016 31.907 1.00 8.13 N

ATOM 3905 CA ASP B 133 9.610 -0.697 32.496 1.00 8.05 C

ATOM 3906 CB ASP B 133 9.127 -1.807 31.561 1.00 8.00 C

ATOM 3907 CG ASP B 133 8.619 -1.270 30.242 1.00 8.09 C

ATOM 3908 ODl ASP B 133 7.580 -0.579 30.244 1.00 8.39 O

ATOM 3909 OD2 ASP B 133 9.261 -1.536 29.206 1.00 6.83 O

ATOM 3910 C ASP B 133 9.881 -1.259 33.892 1.00 8.07 C

ATOM 3911 O ASP B 133 8.980 -1.813 34.530 1.00 7.98 O

ATOM 3912 N GLY B 134 11.114 -1.113 34.368 1.00 7.86 N

ATOM 3913 CA GLY B 134 11.459 -1.575 35.706 1.00 7.47 C

ATOM 3914 C GLY B 134 12.916 -1.421 36.094 1.00 7.60 C

ATOM 3915 O GLY B 134 13.732 -0.923 35.310 1.00 7.05 O

ATOM 3916 N LEU B 135 13.223 -1.840 37.321 1.00 7.75 N

ATOM 3917 CA LEU B 135 14.578 -1.816 37.863 1.00 8.16 C

ATOM 3918 CB LEU B 135 14.636 -1.017 39.181 1.00 8.03 C

ATOM 3919 CG LEU B 135 16.032 -0.681 39.738 1.00 8.45 C

ATOM 3920 CDl LEU B 135 16.694 0.429 38.936 1.00 7.43 C

ATOM 3921 CD2 LEU B 135 15.973 -0.294 41.211 1.00 8.18 C

ATOM 3922 C LEU B 135 15.095 -3.230 38.111 1.00 8.32 C

ATOM 3923 O LEU B 135 14.384 -4.077 38.643 1.00 8.53 O

ATOM 3924 N ASP B 136 16.342 -3.470 37.721 1.00 8.58 N

ATOM 3925 CA ASP B 136 17.038 -4.699 38.067 1.00 8.90 C

ATOM 3926 CB ASP B 136 17.624 -5.362 36.813 1.00 8.42 C

ATOM 3927 CG ASP B 136 18.227 -6.734 37.101 1.00 8.67 C

ATOM 3928 ODl ASP B 136 17.537 -7.581 37.712 1.00 7.28 O

ATOM 3929 OD2 ASP B 136 19.396 -6.959 36.722 1.00 7.13 O

ATOM 3930 C ASP B 136 18.138 -4.356 39.069 1.00 9.63 C

ATOM 3931 O ASP B 136 18.974 -3.495 38.795 1.00 9.89 O

ATOM 3932 N PHE B 137 18.113 -4.997 40.239 1.00 10.17 N

ATOM 3933 CA PHE B 137 19.162 -4.807 41.241 1.00 10.84 C

ATOM 3934 CB PHE B 137 18.650 -5.131 42.653 1.00 10.80 C

ATOM 3935 CG PHE B 137 17.816 -4.043 43.279 1.00 10.99 C

ATOM 3936 CDl PHE B 137 16.439 -4.197 43.407 1.00 10.47 C

ATOM 3937 CEl PHE B 137 15.662 -3.203 43.992 1.00 10.92 C

ATOM 3938 CZ PHE B 137 16.262 -2.036 44.462 1.00 10.53 C

ATOM 3939 CE2 PHE B 137 17.640 -1.870 44.347 1.00 10.52 C

ATOM 3940 CD2 PHE B 137 18.411 -2.875 43.761 1.00 10.68 C

ATOM 3941 C PHE B 137 20.356 -5.705 40.924 1.00 11.35 C

ATOM 3942 O PHE B 137 20.213 -6.922 40.857 1.00 10.93 O

ATOM 3943 N ASP B 138 21.525 -5.106 40.716 1.00 12.11 N

ATOM 3944 CA ASP B 138 22.767 -5.877 40.587 1.00 13.33 C

ATOM 3945 CB ASP B 138 23.422 -5.675 39.209 1.00 13.57 C

ATOM 3946 CG ASP B 138 22.574 -6.218 38.063 1.00 15.93 C

ATOM 3947 ODl ASP B 138 23.124 -6.932 37.188 1.00 18.39 O

ATOM 3948 OD2 ASP B 138 21.359 -5.926 38.022 1.00 18.20 O W2025-7029WO / AM102903-PCT

ATOM 3949 C ASP B 138 23.735 -5.535 41.730 1.00 13.44 C

ATOM 3950 O ASP B 138 24.893 -5.166 41.508 1.00 13.28 O

ATOM 3951 N TRP B 139 23.231 -5.651 42.956 1.00 13.92 N

ATOM 3952 CA TRP B 139 24.024 -5.459 44.165 1.00 14.44 C

ATOM 3953 CB TRP B 139 23.091 -5.293 45.373 1.00 14.08 C

ATOM 3954 CG TRP B 139 23.756 -5.008 46.698 1.00 13.74 C

ATOM 3955 CDl TRP B 139 25.087 -5.132 47.011 1.00 13.52 C

ATOM 3956 NEl TRP B 139 25.300 -4.798 48.328 1.00 13.04 N

ATOM 3957 CE2 TRP B 139 24.100 -4.467 48.900 1.00 13.63 C

ATOM 3958 CD2 TRP B 139 23.102 -4.595 47.901 1.00 13.45 C

ATOM 3959 CE3 TRP B 139 21.771 -4.305 48.233 1.00 12.96 C

ATOM 3960 CZ3 TRP B 139 21.478 -3.904 49.539 1.00 13.47 C

ATOM 3961 CH2 TRP B 139 22.494 -3.786 50.509 1.00 13.74 C

ATOM 3962 CZ2 TRP B 139 23.807 -4.061 50.209 1.00 13.16 C

ATOM 3963 C TRP B 139 24.927 -6.679 44.339 1.00 15.02 C

ATOM 3964 O TRP B 139 24.444 -7.796 44.545 1.00 15.01 O

ATOM 3965 N GLU B 140 26.235 -6.454 44.237 1.00 15.75 N

ATOM 3966 CA GLU B 140 27.220 -7.528 44.332 1.00 16.97 C

ATOM 3967 CB GLU B 140 27.974 -7.689 42.999 1.00 16.89 C

ATOM 3968 CG GLU B 140 27.092 -8.102 41.818 1.00 17.26 C

ATOM 3969 CD GLU B 140 27.813 -8.056 40.475 1.00 17.70 C

ATOM 3970 OEl GLU B 140 29.035 -7.801 40.443 1.00 19.43 O

ATOM 3971 OE2 GLU B 140 27.156 -8.273 39.439 1.00 19.00 O

ATOM 3972 C GLU B 140 28.207 -7.282 45.480 1.00 17.45 C

ATOM 3973 O GLU B 140 29.226 -6.620 45.282 1.00 17.61 O

ATOM 3974 N TYR B 141 27.928 -7.792 46.682 1.00 18.12 N

ATOM 3975 CA TYR B 141 26.727 -8.543 47.033 1.00 18.82 C

ATOM 3976 CB TYR B 141 27.029 -10.048 47.058 1.00 19.13 C

ATOM 3977 CG TYR B 141 27.405 -10.634 45.715 1.00 19.17 C

ATOM 3978 CDl TYR B 141 28.742 -10.732 45.323 1.00 19.07 C

ATOM 3979 CEl TYR B 141 29.088 -11.264 44.085 1.00 19.00 C

ATOM 3980 CZ TYR B 141 28.089 -11.709 43.233 1.00 19.12 C

ATOM 3981 OH TYR B 141 28.417 -12.236 42.011 1.00 19.84 O

ATOM 3982 CE2 TYR B 141 26.756 -11.621 43.601 1.00 19.01 C

ATOM 3983 CD2 TYR B 141 26.422 -11.091 44.836 1.00 18.78 C

ATOM 3984 C TYR B 141 26.291 -8.095 48.430 1.00 19.34 C

ATOM 3985 O TYR B 141 27.114 -7.587 49.191 1.00 19.06 O

ATOM 3986 N PRO B 142 24.998 -8.274 48.780 1.00 20.09 N

ATOM 3987 CA PRO B 142 24.611 -8.008 50.171 1.00 20.78 C

ATOM 3988 CB PRO B 142 23.092 -8.226 50.170 1.00 20.57 C

ATOM 3989 CG PRO B 142 22.683 -8.185 48.734 1.00 20.38 C

ATOM 3990 CD PRO B 142 23.848 -8.706 47.965 1.00 19.96 C

ATOM 3991 C PRO B 142 25.289 -9.003 51.116 1.00 21.61 C

ATOM 3992 O PRO B 142 25.404 -10.182 50.783 1.00 21.72 O

ATOM 3993 N GLY B 143 25.762 -8.523 52.262 1.00 22.68 N

ATOM 3994 CA GLY B 143 26.396 -9.385 53.264 1.00 24.12 C

ATOM 3995 C GLY B 143 27.756 -9.946 52.878 1.00 25.24 C

ATOM 3996 O GLY B 143 28.239 -10.896 53.499 1.00 25.47 O

ATOM 3997 N SER B 144 28.366 -9.367 51.845 1.00 26.17 N

ATOM 3998 CA SER B 144 29.715 -9.743 51.401 1.00 27.20 C

ATOM 3999 CB SER B 144 29.705 -11.033 50.556 1.00 27.19 C

ATOM 4000 OG SER B 144 28.479 -11.217 49.863 1.00 28.48 O

ATOM 4001 C SER B 144 30.380 -8.601 50.635 1.00 27.63 C

ATOM 4002 O SER B 144 29.705 -7.677 50.173 1.00 27.71 O

ATOM 4003 N ARG B 145 31.706 -8.668 50.519 1.00 28.08 N

ATOM 4004 CA ARG B 145 32.489 -7.675 49.782 1.00 28.28 C

ATOM 4005 CB ARG B 145 31.997 -7.585 48.332 1.00 28.51 C

ATOM 4006 CG ARG B 145 33.080 -7.337 47.316 1.00 29.19 C

ATOM 4007 CD ARG B 145 32.497 -7.365 45.923 1.00 30.35 C

ATOM 4008 NE ARG B 145 33.467 -6.924 44.926 1.00 31.20 N

ATOM 4009 CZ ARG B 145 33.147 -6.387 43.754 1.00 31.70 C

ATOM 4010 NHl ARG B 145 34.108 -6.015 42.918 1.00 32.07 N

ATOM 4011 NH2 ARG B 145 31.870 -6.211 43.422 1.00 31.45 N W2025-7029WO / AM102903-PCT

ATOM 4012 C ARG B 145 32.464 -6.301 50.466 1.00 28.26 C

ATOM 4013 O ARG B 145 32.342 -5.259 49.806 1.00 28.55 O

ATOM 4014 N GLY B 146 32.586 -6.311 51.794 1.00 27.90 N

ATOM 4015 CA GLY B 146 32.571 -5.085 52.593 1.00 27.38 C

ATOM 4016 C GLY B 146 31.193 -4.677 53.088 1.00 27.01 C

ATOM 4017 O GLY B 146 31.042 -3.638 53.735 1.00 26.95 O

ATOM 4018 N SER B 147 30.188 -5.492 52.774 1.00 26.53 N

ATOM 4019 CA SER B 147 28.810 -5.231 53.185 1.00 26.23 C

ATOM 4020 CB SER B 147 27.833 -5.688 52.095 1.00 26.13 C

ATOM 4021 OG SER B 147 26.483 -5.529 52.499 1.00 25.98 O

ATOM 4022 C SER B 147 28.513 -5.939 54.511 1.00 25.93 C

ATOM 4023 O SER B 147 28.647 -7.160 54.600 1.00 26.18 O

ATOM 4024 N PRO B 148 28.110 -5.173 55.543 1.00 25.80 N

ATOM 4025 CA PRO B 148 27.824 -5.707 56.881 1.00 25.48 C

ATOM 4026 CB PRO B 148 27.528 -4.446 57.700 1.00 25.40 C

ATOM 4027 CG PRO B 148 27.082 -3.446 56.706 1.00 25.51 C

ATOM 4028 CD PRO B 148 27.886 -3.717 55.482 1.00 25.69 C

ATOM 4029 C PRO B 148 26.623 -6.676 56.891 1.00 25.26 C

ATOM 4030 O PRO B 148 25.769 -6.599 56.000 1.00 25.16 O

ATOM 4031 N PRO B 149 26.551 -7.576 57.899 1.00 24.91 N

ATOM 4032 CA PRO B 149 25.596 -8.693 57.886 1.00 24.48 C

ATOM 4033 CB PRO B 149 25.939 -9.466 59.168 1.00 24.58 C

ATOM 4034 CG PRO B 149 27.309 -9.012 59.547 1.00 24.82 C

ATOM 4035 CD PRO B 149 27.371 -7.587 59.126 1.00 25.12 C

ATOM 4036 C PRO B 149 24.120 -8.287 57.910 1.00 23.95 C

ATOM 4037 O PRO B 149 23.264 -9.079 57.500 1.00 23.89 O

ATOM 4038 N GLN B 150 23.833 -7.074 58.382 1.00 23.34 N

ATOM 4039 CA GLN B 150 22.457 -6.581 58.486 1.00 22.63 C

ATOM 4040 CB GLN B 150 22.356 -5.417 59.480 1.00 22.82 C

ATOM 4041 CG GLN B 150 23.086 -4.140 59.073 1.00 23.31 C

ATOM 4042 CD GLN B 150 24.510 -4.068 59.600 1.00 24.18 C

ATOM 4043 OEl GLN B 150 25.118 -5.084 59.951 1.00 24.55 O

ATOM 4044 NE2 GLN B 150 25.052 -2.857 59.652 1.00 24.39 N

ATOM 4045 C GLN B 150 21.866 -6.184 57.132 1.00 22.03 C

ATOM 4046 O GLN B 150 20.649 -6.051 57.001 1.00 21.72 O

ATOM 4047 N ASP B 151 22.732 -6.002 56.136 1.00 21.17 N

ATOM 4048 CA ASP B 151 22.300 -5.685 54.769 1.00 20.76 C

ATOM 4049 CB ASP B 151 23.502 -5.364 53.878 1.00 20.84 C

ATOM 4050 CG ASP B 151 23.990 -3.938 54.042 1.00 21.30 C

ATOM 4051 ODl ASP B 151 23.432 -3.192 54.875 1.00 21.44 O

ATOM 4052 OD2 ASP B 151 24.936 -3.559 53.323 1.00 22.40 O

ATOM 4053 C ASP B 151 21.462 -6.783 54.124 1.00 20.03 C

ATOM 4054 O ASP B 151 20.604 -6.494 53.294 1.00 20.01 O

ATOM 4055 N LYS B 152 21.722 -8.036 54.506 1.00 19.46 N

ATOM 4056 CA LYS B 152 20.950 -9.187 54.035 1.00 18.74 C

ATOM 4057 CB LYS B 152 21.443 -10.469 54.716 1.00 18.94 C

ATOM 4058 CG LYS B 152 20.617 -11.724 54.433 1.00 18.55 C

ATOM 4059 CD LYS B 152 21.248 -12.939 55.105 1.00 19.05 C

ATOM 4060 CE LYS B 152 20.264 -14.086 55.240 1.00 18.50 C

ATOM 4061 NZ LYS B 152 20.929 -15.328 55.745 1.00 18.75 N

ATOM 4062 C LYS B 152 19.446 -8.988 54.263 1.00 18.44 C

ATOM 4063 O LYS B 152 18.638 -9.167 53.341 1.00 18.27 O

ATOM 4064 N HIS B 153 19.084 -8.602 55.486 1.00 17.64 N

ATOM 4065 CA HIS B 153 17.695 -8.307 55.813 1.00 17.00 C

ATOM 4066 CB HIS B 153 17.466 -8.298 57.327 1.00 17.00 C

ATOM 4067 CG HIS B 153 16.085 -7.868 57.720 1.00 16.57 C

ATOM 4068 NDl HIS B 153 14.955 -8.547 57.319 1.00 16.27 N

ATOM 4069 CEl HIS B 153 13.885 -7.941 57.803 1.00 16.54 C

ATOM 4070 NE2 HIS B 153 14.281 -6.893 58.505 1.00 16.50 N

ATOM 4071 CD2 HIS B 153 15.653 -6.822 58.464 1.00 16.15 C

ATOM 4072 C HIS B 153 17.226 -6.987 55.210 1.00 16.59 C

ATOM 4073 O HIS B 153 16.109 -6.902 54.704 1.00 16.64 O

ATOM 4074 N LEU B 154 18.076 -5.965 55.274 1.00 16.27 N W2025-7029WO / AM102903-PCT

ATOM 4075 CA LEU B 154 17.730 -4.631 54.770 1.00 16.09 C

ATOM 4076 CB LEU B 154 18.800 -3.601 55.151 1.00 16.10 C

ATOM 4077 CG LEU B 154 18.908 -3.215 56.634 1.00 16.29 C

ATOM 4078 CDl LEU B 154 20.225 -2.505 56.914 1.00 16.07 C

ATOM 4079 CD2 LEU B 154 17.735 -2.348 57.079 1.00 16.94 C

ATOM 4080 C LEU B 154 17.463 -4.619 53.260 1.00 15.89 C

ATOM 4081 O LEU B 154 16.734 -3.755 52.766 1.00 15.70 O

ATOM 4082 N PHE B 155 18.044 -5.584 52.540 1.00 15.62 N

ATOM 4083 CA PHE B 155 17.777 -5.749 51.110 1.00 15.24 C

ATOM 4084 CB PHE B 155 18.791 -6.694 50.453 1.00 15.42 C

ATOM 4085 CG PHE B 155 18.639 -6.814 48.953 1.00 15.39 C

ATOM 4086 CDl PHE B 155 18.543 -5.676 48.148 1.00 15.69 C

ATOM 4087 CEl PHE B 155 18.414 -5.780 46.761 1.00 15.10 C

ATOM 4088 CZ PHE B 155 18.376 -7.039 46.164 1.00 15.43 C

ATOM 4089 CE2 PHE B 155 18.475 -8.187 46.954 1.00 15.30 C

ATOM 4090 CD2 PHE B 155 18.610 -8.067 48.344 1.00 15.61 C

ATOM 4091 C PHE B 155 16.347 -6.232 50.878 1.00 15.02 C

ATOM 4092 O PHE B 155 15.672 -5.758 49.960 1.00 14.84 O

ATOM 4093 N THR B 156 15.894 -7.170 51.711 1.00 14.78 N

ATOM 4094 CA THR B 156 14.506 -7.633 51.670 1.00 14.62 C

ATOM 4095 CB THR B 156 14.223 -8.763 52.695 1.00 14.62 C

ATOM 4096 OGl THR B 156 15.209 -9.796 52.579 1.00 14.33 O

ATOM 4097 CG2 THR B 156 12.847 -9.366 52.457 1.00 14.18 C

ATOM 4098 C THR B 156 13.555 -6.459 51.926 1.00 14.47 C

ATOM 4099 O THR B 156 12.564 -6.294 51.210 1.00 14.40 O

ATOM 4100 N VAL B 157 13.879 -5.654 52.940 1.00 14.05 N

ATOM 4101 CA VAL B 157 13.105 -4.460 53.297 1.00 14.01 C

ATOM 4102 CB VAL B 157 13.665 -3.772 54.573 1.00 13.82 C

ATOM 4103 CGl VAL B 157 12.842 -2.544 54.930 1.00 14.21 C

ATOM 4104 CG2 VAL B 157 13.677 -4.744 55.745 1.00 14.46 C

ATOM 4105 C VAL B 157 13.046 -3.458 52.134 1.00 13.65 C

ATOM 4106 O VAL B 157 11.977 -2.934 51.811 1.00 13.76 O

ATOM 4107 N LEU B 158 14.196 -3.210 51.509 1.00 13.25 N

ATOM 4108 CA LEU B 158 14.276 -2.348 50.332 1.00 12.83 C

ATOM 4109 CB LEU B 158 15.717 -2.273 49.817 1.00 12.76 C

ATOM 4110 CG LEU B 158 15.971 -1.492 48.524 1.00 12.60 C

ATOM 4111 CDl LEU B 158 15.763 0.026 48.720 1.00 12.24 C

ATOM 4112 CD2 LEU B 158 17.362 -1.786 48.002 1.00 12.20 C

ATOM 4113 C LEU B 158 13.337 -2.796 49.204 1.00 12.77 C

ATOM 4114 O LEU B 158 12.569 -1.985 48.674 1.00 12.40 O

ATOM 4115 N VAL B 159 13.402 -4.081 48.849 1.00 12.82 N

ATOM 4116 CA VAL B 159 12.607 -4.617 47.738 1.00 13.09 C

ATOM 4117 CB VAL B 159 13.041 -6.064 47.346 1.00 12.96 C

ATOM 4118 CGl VAL B 159 12.070 -6.680 46.351 1.00 12.44 C

ATOM 4119 CG2 VAL B 159 14.458 -6.062 46.764 1.00 12.79 C

ATOM 4120 C VAL B 159 11.116 -4.541 48.077 1.00 13.63 C

ATOM 4121 O VAL B 159 10.301 -4.152 47.235 1.00 13.91 O

ATOM 4122 N GLN B 160 10.781 -4.901 49.317 1.00 13.95 N

ATOM 4123 CA GLN B 160 9.420 -4.781 49.852 1.00 14.69 C

ATOM 4124 CB GLN B 160 9.407 -5.141 51.346 1.00 14.22 C

ATOM 4125 CG GLN B 160 8.044 -5.024 52.025 1.00 15.63 C

ATOM 4126 CD GLN B 160 8.137 -4.903 53.548 1.00 16.38 C

ATOM 4127 OEl GLN B 160 9.204 -5.089 54.147 1.00 18.98 O

ATOM 4128 NE2 GLN B 160 7.010 -4.584 54.180 1.00 18.09 N

ATOM 4129 C GLN B 160 8.862 -3.369 49.640 1.00 14.31 C

ATOM 4130 O GLN B 160 7.793 -3.199 49.047 1.00 14.51 O

ATOM 4131 N GLU B 161 9.608 -2.373 50.118 1.00 14.32 N

ATOM 4132 CA GLU B 161 9.227 -0.961 50.030 1.00 14.22 C

ATOM 4133 CB GLU B 161 10.183 -0.105 50.860 1.00 14.09 C

ATOM 4134 CG GLU B 161 9.959 -0.231 52.356 1.00 14.19 C

ATOM 4135 CD GLU B 161 11.075 0.366 53.179 1.00 14.23 C

ATOM 4136 OEl GLU B 161 12.054 0.899 52.601 1.00 14.79 O

ATOM 4137 OE2 GLU B 161 10.968 0.296 54.420 1.00 14.93 O W2025-7029WO / AM102903-PCT

ATOM 4138 C GLU B 161 9.164 -0.416 48.610 1.00 14.12 C

ATOM 4139 O GLU B 161 8.345 0.452 48.316 1.00 14.00 O

ATOM 4140 N MET B 162 10.042 -0.909 47.740 1.00 14.19 N

ATOM 4141 CA MET B 162 10.031 -0.503 46.339 1.00 14.24 C

ATOM 4142 CB MET B 162 11.332 -0.907 45.645 1.00 14.09 C

ATOM 4143 CG MET B 162 11.323 -0.665 44.144 1.00 14.08 C

ATOM 4144 SD MET B 162 12.937 -0.816 43.377 1.00 14.03 S

ATOM 4145 CE MET B 162 13.715 0.701 43.934 1.00 12.76 C

ATOM 4146 C MET B 162 8.828 -1.107 45.616 1.00 14.72 C

ATOM 4147 O MET B 162 8.152 -0.424 44.837 1.00 14.66 O

ATOM 4148 N ARG B 163 8.576 -2.388 45.883 1.00 14.89 N

ATOM 4149 CA ARG B 163 7.474 -3.116 45.274 1.00 15.41 C

ATOM 4150 CB ARG B 163 7.491 -4.583 45.739 1.00 15.31 C

ATOM 4151 CG ARG B 163 6.287 -5.432 45.344 1.00 15.85 C

ATOM 4152 CD ARG B 163 6.200 -5.678 43.849 1.00 15.62 C

ATOM 4153 NE ARG B 163 4.949 -6.349 43.507 1.00 16.14 N

ATOM 4154 CZ ARG B 163 4.803 -7.663 43.346 1.00 16.25 C

ATOM 4155 NHl ARG B 163 3.610 -8.157 43.039 1.00 16.71 N

ATOM 4156 NH2 ARG B 163 5.836 -8.486 43.483 1.00 16.24 N

ATOM 4157 C ARG B 163 6.145 -2.426 45.588 1.00 15.62 C

ATOM 4158 O ARG B 163 5.337 -2.190 44.693 1.00 15.55 O

ATOM 4159 N GLU B 164 5.947 -2.080 46.857 1.00 16.14 N

ATOM 4160 CA GLU B 164 4.743 -1.368 47.290 1.00 16.82 C

ATOM 4161 CB GLU B 164 4.676 -1.308 48.821 1.00 16.82 C

ATOM 4162 CG GLU B 164 4.446 -2.688 49.448 1.00 18.42 C

ATOM 4163 CD GLU B 164 4.734 -2.752 50.942 1.00 19.05 C

ATOM 4164 OEl GLU B 164 4.749 -3.883 51.485 1.00 21.39 O

ATOM 4165 OE2 GLU B 164 4.940 -1.686 51.574 1.00 23.14 O

ATOM 4166 C GLU B 164 4.633 0.024 46.660 1.00 16.11 C

ATOM 4167 O GLU B 164 3.565 0.400 46.172 1.00 15.91 O

ATOM 4168 N ALA B 165 5.738 0.771 46.652 1.00 15.68 N

ATOM 4169 CA ALA B 165 5.771 2.094 46.023 1.00 15.47 C

ATOM 4170 CB ALA B 165 7.113 2.769 46.256 1.00 15.32 C

ATOM 4171 C ALA B 165 5.446 2.025 44.526 1.00 15.10 C

ATOM 4172 O ALA B 165 4.714 2.868 44.010 1.00 15.26 O

ATOM 4173 N PHE B 166 5.991 1.016 43.845 1.00 14.98 N

ATOM 4174 CA PHE B 166 5.686 0.733 42.433 1.00 14.56 C

ATOM 4175 CB PHE B 166 6.526 -0.451 41.934 1.00 14.32 C

ATOM 4176 CG PHE B 166 7.947 -0.093 41.548 1.00 13.57 C

ATOM 4177 CDl PHE B 166 8.458 1.186 41.761 1.00 13.30 C

ATOM 4178 CEl PHE B 166 9.777 1.505 41.403 1.00 13.65 C

ATOM 4179 CZ PHE B 166 10.591 0.533 40.840 1.00 13.30 C

ATOM 4180 CE2 PHE B 166 10.096 -0.752 40.634 1.00 12.82 C

ATOM 4181 CD2 PHE B 166 8.781 -1.057 40.992 1.00 12.91 C

ATOM 4182 C PHE B 166 4.195 0.438 42.219 1.00 14.80 C

ATOM 4183 O PHE B 166 3.602 0.881 41.232 1.00 14.53 O

ATOM 4184 N GLU B 167 3.601 -0.313 43.145 1.00 15.09 N

ATOM 4185 CA GLU B 167 2.167 -0.605 43.111 1.00 15.48 C

ATOM 4186 CB GLU B 167 1.803 -1.668 44.156 1.00 15.41 C

ATOM 4187 CG GLU B 167 1.986 -3.089 43.657 1.00 16.04 C

ATOM 4188 CD GLU B 167 1.911 -4.143 44.749 1.00 16.24 C

ATOM 4189 OEl GLU B 167 1.164 -3.954 45.741 1.00 17.03 O

ATOM 4190 OE2 GLU B 167 2.602 -5.174 44.597 1.00 16.13 O

ATOM 4191 C GLU B 167 1.330 0.657 43.306 1.00 15.55 C

ATOM 4192 O GLU B 167 0.363 0.887 42.578 1.00 15.53 O

ATOM 4193 N GLN B 168 1.721 1.472 44.282 1.00 15.89 N

ATOM 4194 CA GLN B 168 1.048 2.734 44.579 1.00 16.50 C

ATOM 4195 CB GLN B 168 1.618 3.356 45.862 1.00 16.42 C

ATOM 4196 CG GLN B 168 1.219 2.590 47.130 1.00 17.96 C

ATOM 4197 CD GLN B 168 2.092 2.889 48.349 1.00 18.10 C

ATOM 4198 OEl GLN B 168 3.120 3.567 48.257 1.00 20.74 O

ATOM 4199 NE2 GLN B 168 1.682 2.364 49.502 1.00 19.98 N

ATOM 4200 C GLN B 168 1.105 3.716 43.402 1.00 16.11 C W2025-7029WO / AM102903-PCT

ATOM 4201 O GLN B 168 0.077 4.286 43.019 1.00 15.71 O

ATOM 4202 N GLU B 169 2.294 3.887 42.823 1.00 16.03 N

ATOM 4203 CA GLU B 169 2.489 4.795 41.686 1.00 16.11 C

ATOM 4204 CB GLU B 169 3.980 4.933 41.345 1.00 16.26 C

ATOM 4205 CG GLU B 169 4.296 5.969 40.255 1.00 15.86 C

ATOM 4206 CD GLU B 169 4.518 5.361 38.864 1.00 16.06 C

ATOM 4207 OEl GLU B 169 4.205 4.172 38.650 1.00 15.93 O

ATOM 4208 OE2 GLU B 169 5.013 6.088 37.977 1.00 15.41 O

ATOM 4209 C GLU B 169 1.689 4.355 40.456 1.00 16.19 C

ATOM 4210 O GLU B 169 1.135 5.188 39.742 1.00 15.81 O

ATOM 4211 N ALA B 170 1.626 3.048 40.224 1.00 16.56 N

ATOM 4212 CA ALA B 170 0.848 2.489 39.114 1.00 17.49 C

ATOM 4213 CB ALA B 170 0.957 0.976 39.101 1.00 17.18 C

ATOM 4214 C ALA B 170 0.622 2.923 39.152 1.00 18.09 C

ATOM 4215 O ALA B 170 1.175 3.335 38.134 1.00 17.94 O

ATOM 4216 N LYS B 171 1.237 2.841 40.331 1.00 19.27 N

ATOM 4217 CA LYS B 171 2.624 3.278 40.526 1.00 20.50 C

ATOM 4218 CB LYS B 171 3.165 2.776 41.869 1.00 20.62 C

ATOM 4219 CG LYS B 171 3.484 1.280 41.893 1.00 22.29 C

ATOM 4220 CD LYS B 171 4.741 0.967 41.078 1.00 25.22 C

ATOM 4221 CE LYS B 171 4.958 -0.535 40.915 1.00 26.55 C

ATOM 4222 NZ LYS B 171 6.136 -0.824 40.035 1.00 27.51 N

ATOM 4223 C LYS B 171 2.751 4.797 40.438 1.00 21.01 C

ATOM 4224 O LYS B 171 3.760 5.321 39.954 1.00 21.26 O

ATOM 4225 N GLN B 172 1.715 5.489 40.908 1.00 21.50 N

ATOM 4226 CA GLN B 172 1.632 6.945 40.871 1.00 22.11 C

ATOM 4227 CB GLN B 172 0.332 7.389 41.554 1.00 22.12 C

ATOM 4228 CG GLN B 172 0.082 8.888 41.657 1.00 22.98 C

ATOM 4229 CD GLN B 172 1.262 9.198 42.314 1.00 23.53 C

ATOM 4230 OEl GLN B 172 1.320 9.718 43.433 1.00 25.61 O

ATOM 4231 NE2 GLN B 172 2.349 8.858 41.626 1.00 24.73 N

ATOM 4232 C GLN B 172 1.706 7.469 39.435 1.00 21.88 C

ATOM 4233 O GLN B 172 2.573 8.283 39.105 1.00 22.10 O

ATOM 4234 N ILE B 173 0.811 6.977 38.583 1.00 21.57 N

ATOM 4235 CA ILE B 173 0.664 7.513 37.231 1.00 21.39 C

ATOM 4236 CB ILE B 173 0.828 7.633 36.821 1.00 21.33 C

ATOM 4237 CGl ILE B 173 1.443 6.259 36.529 1.00 21.02 C

ATOM 4238 CDl ILE B 173 2.652 6.320 35.605 1.00 21.50 C

ATOM 4239 CG2 ILE B 173 1.618 8.375 37.906 1.00 21.59 C

ATOM 4240 C ILE B 173 1.483 6.756 36.178 1.00 21.18 C

ATOM 4241 O ILE B 173 1.505 7.140 35.005 1.00 21.21 O

ATOM 4242 N ASN B 174 2.167 5.701 36.625 1.00 20.88 N

ATOM 4243 CA ASN B 174 2.984 4.824 35.773 1.00 20.81 C

ATOM 4244 CB ASN B 174 4.280 5.519 35.320 1.00 21.21 C

ATOM 4245 CG ASN B 174 5.345 4.533 34.872 1.00 22.55 C

ATOM 4246 ODl ASN B 174 5.593 3.520 35.532 1.00 24.34 O

ATOM 4247 ND2 ASN B 174 5.983 4.825 33.741 1.00 23.79 N

ATOM 4248 C ASN B 174 2.223 4.197 34.593 1.00 20.21 C

ATOM 4249 O ASN B 174 2.621 4.322 33.429 1.00 20.29 O

ATOM 4250 N LYS B 175 1.116 3.535 34.919 1.00 19.40 N

ATOM 4251 CA LYS B 175 0.316 2.785 33.951 1.00 18.69 C

ATOM 4252 CB LYS B 175 0.928 3.584 33.543 1.00 18.66 C

ATOM 4253 CG LYS B 175 0.637 4.775 32.631 1.00 19.25 C

ATOM 4254 CD LYS B 175 1.912 5.381 32.061 1.00 19.29 C

ATOM 4255 CE LYS B 175 1.601 6.541 31.121 1.00 20.71 C

ATOM 4256 NZ LYS B 175 2.780 6.917 30.280 1.00 20.66 N

ATOM 4257 C LYS B 175 0.077 1.440 34.576 1.00 17.80 C

ATOM 4258 O LYS B 175 0.024 1.286 35.800 1.00 17.76 O

ATOM 4259 N PRO B 176 0.500 0.454 33.750 1.00 16.87 N

ATOM 4260 CA PRO B 176 0.983 -0.801 34.338 1.00 16.18 C

ATOM 4261 CB PRO B 176 1.423 -1.620 33.119 1.00 16.27 C

ATOM 4262 CG PRO B 176 0.659 -1.039 31.979 1.00 16.68 C

ATOM 4263 CD PRO B 176 0.550 0.416 32.277 1.00 16.78 C W2025-7029WO / AM102903-PCT

ATOM 4264 C PRO B 176 2.166 -0.571 35.288 1.00 15.41 C

ATOM 4265 O PRO B 176 3.038 0.258 35.011 1.00 14.89 O

ATOM 4266 N ARG B 177 2.162 -1.302 36.399 1.00 14.45 N

ATOM 4267 CA ARG B 177 3.200 -1.229 37.427 1.00 14.03 C

ATOM 4268 CB ARG B 177 2.898 -2.276 38.511 1.00 14.06 C

ATOM 4269 CG ARG B 177 3.973 -2.453 39.551 1.00 14.85 C

ATOM 4270 CD ARG B 177 3.558 -3.413 40.644 1.00 14.55 C

ATOM 4271 NE ARG B 177 3.486 -4.822 40.248 1.00 15.15 N

ATOM 4272 CZ ARG B 177 4.528 -5.646 40.157 1.00 15.90 C

ATOM 4273 NHl ARG B 177 5.768 -5.211 40.389 1.00 16.23 N

ATOM 4274 NH2 ARG B 177 4.330 -6.913 39.813 1.00 15.64 N

ATOM 4275 C ARG B 177 4.621 -1.416 36.871 1.00 13.19 C

ATOM 4276 O ARG B 177 4.838 -2.205 35.952 1.00 12.51 O

ATOM 4277 N LEU B 178 5.573 -0.662 37.419 1.00 12.53 N

ATOM 4278 CA LEU B 178 6.987 -0.903 37.145 1.00 12.28 C

ATOM 4279 CB LEU B 178 7.862 0.241 37.682 1.00 12.11 C

ATOM 4280 CG LEU B 178 7.781 1.585 36.948 1.00 12.25 C

ATOM 4281 CDl LEU B 178 8.299 2.741 37.811 1.00 10.55 C

ATOM 4282 CD2 LEU B 178 8.516 1.529 35.614 1.00 11.92 C

ATOM 4283 C LEU B 178 7.415 -2.237 37.759 1.00 12.09 C

ATOM 4284 O LEU B 178 6.909 -2.641 38.810 1.00 11.83 O

ATOM 4285 N MET B 179 8.339 -2.919 37.094 1.00 11.85 N

ATOM 4286 CA MET B 179 8.851 -4.197 37.582 1.00 12.40 C

ATOM 4287 CB MET B 179 9.267 -5.083 36.406 1.00 12.13 C

ATOM 4288 CG MET B 179 8.111 -5.705 35.655 1.00 13.12 C

ATOM 4289 SD MET B 179 8.655 -6.516 34.140 1.00 15.43 S

ATOM 4290 CE MET B 179 9.857 -7.686 34.776 1.00 15.38 C

ATOM 4291 C MET B 179 10.036 -4.014 38.529 1.00 11.32 C

ATOM 4292 O MET B 179 10.812 -3.062 38.389 1.00 11.12 O

ATOM 4293 N VAL B 180 10.158 -4.923 39.495 1.00 10.55 N

ATOM 4294 CA VAL B 180 11.346 -5.003 40.344 1.00 9.79 C

ATOM 4295 CB VAL B 180 11.101 -4.515 41.810 1.00 10.00 C

ATOM 4296 CGl VAL B 180 9.933 -5.259 42.480 1.00 9.26 C

ATOM 4297 CG2 VAL B 180 12.384 -4.643 42.637 1.00 9.57 C

ATOM 4298 C VAL B 180 11.964 -6.405 40.300 1.00 9.43 C

ATOM 4299 O VAL B 180 11.343 -7.392 40.713 1.00 9.33 O

ATOM 4300 N THR B 181 13.185 -6.477 39.773 1.00 8.86 N

ATOM 4301 CA THR B 181 13.905 -7.740 39.637 1.00 8.21 C

ATOM 4302 CB THR B 181 14.067 -8.150 38.145 1.00 8.50 C

ATOM 4303 OGl THR B 181 14.854 -7.171 37.452 1.00 7.84 O

ATOM 4304 CG2 THR B 181 12.713 -8.304 37.456 1.00 7.86 C

ATOM 4305 C THR B 181 15.280 -7.649 40.302 1.00 8.09 C

ATOM 4306 O THR B 181 15.677 -6.581 40.776 1.00 7.50 O

ATOM 4307 N ALA B 182 16.002 -8.769 40.340 1.00 7.91 N

ATOM 4308 CA ALA B 182 17.361 -8.796 40.888 1.00 8.10 C

ATOM 4309 CB ALA B 182 17.324 -9.069 42.391 1.00 8.30 C

ATOM 4310 C ALA B 182 18.254 -9.820 40.198 1.00 8.23 C

ATOM 4311 O ALA B 182 17.815 -10.931 39.894 1.00 7.47 O

ATOM 4312 N ALA B 183 19.504 -9.429 39.950 1.00 8.51 N

ATOM 4313 CA ALA B 183 20.551 -10.368 39.564 1.00 9.17 C

ATOM 4314 CB ALA B 183 21.601 -9.679 38.693 1.00 9.13 C

ATOM 4315 C ALA B 183 21.184 -10.893 40.846 1.00 9.43 C

ATOM 4316 O ALA B 183 21.667 -10.106 41.662 1.00 9.47 O

ATOM 4317 N VAL B 184 21.180 -12.216 41.029 1.00 9.88 N

ATOM 4318 CA VAL B 184 21.623 -12.812 42.302 1.00 9.94 C

ATOM 4319 CB VAL B 184 20.459 -13.531 43.038 1.00 9.93 C

ATOM 4320 CGl VAL B 184 19.356 -12.538 43.430 1.00 9.47 C

ATOM 4321 CG2 VAL B 184 19.911 -14.678 42.189 1.00 9.35 C

ATOM 4322 C VAL B 184 22.817 -13.776 42.192 1.00 10.18 C

ATOM 4323 O VAL B 184 23.064 -14.370 41.132 1.00 9.94 O

ATOM 4324 N ALA B 185 23.512 -13.948 43.317 1.00 10.60 N

ATOM 4325 CA ALA B 185 24.725 -14.770 43.416 1.00 11.04 C

ATOM 4326 CB ALA B 185 25.351 -14.622 44.806 1.00 11.24 C W2025-7029WO / AM102903-PCT

ATOM 4327 C ALA B 185 24.522 -16 .246 43.097 .00 11.50 C

ATOM 4328 O ALA B 185 23.459 -16.821 43.363 .00 11.22 O

ATOM 4329 N ALA B 186 25.563 -16.843 42.521 .00 12.22 N

ATOM 4330 CA ALA B 186 25.609 -18.274 42.260 .00 13.01 C

ATOM 4331 CB ALA B 186 26.159 -18.541 40.866 .00 12.94 C

ATOM 4332 C ALA B 186 26.436 -19.012 43.312 .00 13.50 C

ATOM 4333 O ALA B 186 26.235 -20.200 43.528 .00 13.74 O

ATOM 4334 N GLY B 187 27.356 -18.301 43.964 .00 14.46 N

ATOM 4335 CA GLY B 187 28.204 -18.883 45.010 .00 15.74 C

ATOM 4336 C GLY B 187 27.458 -19.105 46.317 .00 16.44 C

ATOM 4337 O GLY B 187 26.914 -18.163 46.889 .00 16.39 O

ATOM 4338 N ILE B 188 27.453 -20.353 46.793 .00 17.26 N

ATOM 4339 CA ILE B 188 26.646 -20.757 47.958 .00 17.97 C

ATOM 4340 CB ILE B 188 26.757 _99.288 48.248 1.00 18.07 C

ATOM 4341 CGl ILE B 188 26.381 -23.112 47.006 1.00 18.24 C

ATOM 4342 CDl ILE B 188 24.974 -22.847 46.447 1.00 19.08 C

ATOM 4343 CG2 ILE B 188 25.888 -22.697 49.446 1.00 18.00 C

ATOM 4344 C ILE B 188 26.932 -19.929 49.214 1.00 18.38 C

ATOM 4345 O ILE B 188 26.003 -19.524 49.914 1.00 18.41 O

ATOM 4346 N SER B 189 28.207 -19.658 49.473 1.00 18.99 N

ATOM 4347 CA SER B 189 28.609 -18.794 50.590 1.00 19.70 C

ATOM 4348 CB SER B 189 30.134 -18.791 50.755 1.00 19.80 C

ATOM 4349 OG SER B 189 30.793 -18.887 49.497 1.00 21.54 O

ATOM 4350 C SER B 189 28.060 -17.363 50.470 1.00 19.67 C

ATOM 4351 O SER B 189 27.661 -16.761 51.470 1.00 19.88 O

ATOM 4352 N ASN B 190 28.032 -16.830 49.248 1.00 19.69 N

ATOM 4353 CA ASN B 190 27.439 -15.511 48.987 1.00 19.61 C

ATOM 4354 CB ASN B 190 27.866 -14.983 47.615 1.00 19.72 C

ATOM 4355 CG ASN B 190 29.339 -14.615 47.559 1.00 19.93 C

ATOM 4356 ODl ASN B 190 29.980 -14.381 48.584 1.00 20.22 O

ATOM 4357 ND2 ASN B 190 29.881 -14.557 46.352 1.00 20.59 N

ATOM 4358 C ASN B 190 25.914 -15.512 49.094 1.00 19.34 C

ATOM 4359 O ASN B 190 25.325 -14.535 49.551 1.00 19.47 O

ATOM 4360 N ILE B 191 25.289 -16.607 48.664 1.00 19.09 N

ATOM 4361 CA ILE B 191 23.836 -16.775 48.762 1.00 18.87 C

ATOM 4362 CB ILE B 191 23.350 -18.050 48.019 1.00 18.72 C

ATOM 4363 CGl ILE B 191 23.628 -17.939 46.518 1.00 18.72 C

ATOM 4364 CDl ILE B 191 23.493 -19.246 45.758 1.00 18.52 C

ATOM 4365 CG2 ILE B 191 21.856 -18.294 48.255 1.00 18.71 C

ATOM 4366 C ILE B 191 23.376 -16.805 50.228 1.00 18.92 C

ATOM 4367 O ILE B 191 22.401 -16.140 50.594 1.00 18.57 O

ATOM 4368 N GLN B 192 24.096 -17.563 51.054 1.00 19.00 N

ATOM 4369 CA GLN B 192 23.757 -17.734 52.475 1.00 19.37 C

ATOM 4370 CB GLN B 192 24.582 -18.878 53.098 1.00 19.50 C

ATOM 4371 CG GLN B 192 24.155 -20.266 52.602 1.00 19.85 C

ATOM 4372 CD GLN B 192 25.089 -21.406 53.019 1.00 20.37 C

ATOM 4373 OEl GLN B 192 26.298 -21.220 53.199 1.00 21.06 O

ATOM 4374 NE2 GLN B 192 24.523 -22.604 53.149 1.00 21.47 N

ATOM 4375 C GLN B 192 23.904 -16.442 53.273 1.00 19.11 C

ATOM 4376 O GLN B 192 23.077 -16.131 54.130 1.00 19.32 O

ATOM 4377 N SER B 193 24.947 -15.679 52.967 1.00 19.10 N

ATOM 4378 CA SER B 193 25.205 -14.413 53.641 1.00 19.01 C

ATOM 4379 CB SER B 193 26.710 -14.135 53.657 1.00 19.22 C

ATOM 4380 OG SER B 193 27.246 -14.198 52.345 1.00 20.66 O

ATOM 4381 C SER B 193 24.451 -13.237 53.008 1.00 18.65 C

ATOM 4382 O SER B 193 24.381 -12.157 53.593 1.00 18.60 O

ATOM 4383 N GLY B 194 23.874 -13.458 51.829 1.00 18.37 N

ATOM 4384 CA GLY B 194 23.305 -12.374 51.025 1.00 18.02 C

ATOM 4385 C GLY B 194 21.797 -12.182 51.003 1.00 17.84 C

ATOM 4386 O GLY B 194 21.320 -11.042 50.904 1.00 17.81 O

ATOM 4387 N TYR B 195 21.045 -13.280 51.097 1.00 17.32 N

ATOM 4388 CA TYR B 195 19.608 -13.244 50.802 1.00 17.07 C

ATOM 4389 CB TYR B 195 19.347 -13.746 49.374 1.00 16.75 C W2025-7029WO / AM102903-PCT

ATOM 4390 CG TYR B 195 20.343 -13 .253 48.344 .00 16.32 C

ATOM 4391 CDl TYR B 195 21.451 -14.029 47.986 .00 16.09 C

ATOM 4392 CEl TYR B 195 22.372 -13.572 47.038 .00 15.68 C

ATOM 4393 CZ TYR B 195 22.177 -12.330 46.442 .00 15.51 C

ATOM 4394 OH TYR B 195 23.069 -11.863 45.505 .00 16.16 O

ATOM 4395 CE2 TYR B 195 21.086 -11.551 46.780 .00 15.48 C

ATOM 4396 CD2 TYR B 195 20.176 -12.014 47.725 .00 15.62 C

ATOM 4397 C TYR B 195 18.717 -14.034 51.760 .00 17.19 C

ATOM 4398 O TYR B 195 18.984 -15.201 52.071 .00 17.12 O

ATOM 4399 N GLU B 196 17.641 -13.384 52.198 .00 17.25 N

ATOM 4400 CA GLU B 196 16.532 -14.056 52.864 .00 17.32 C

ATOM 4401 CB GLU B 196 15.781 -13.082 53.786 .00 17.32 C

ATOM 4402 CG GLU B 196 16.659 -12.372 54.817 .00 17.63 C

ATOM 4403 CD GLU B 196 15.885 -11.427 55.738 1.00 18.15 C

ATOM 4404 OEl GLU B 196 16.204 -11.399 56.948 1.00 18.72 O

ATOM 4405 OE2 GLU B 196 14.972 -10.708 55.266 1.00 18.88 O

ATOM 4406 C GLU B 196 15.609 -14.586 51.767 1.00 16.95 C

ATOM 4407 O GLU B 196 14.596 -13.961 51.447 1.00 17.03 O

ATOM 4408 N ILE B 197 15.971 -15.734 51.188 1.00 16.71 N

ATOM 4409 CA ILE B 197 15.292 -16.275 49.992 1.00 16.29 C

ATOM 4410 CB ILE B 197 15.907 -17.627 49.500 1.00 16.32 C

ATOM 4411 CGl ILE B 197 17.411 -17.481 49.237 1.00 16.72 C

ATOM 4412 CDl ILE B 197 18.109 -18.773 48.800 1.00 16.50 C

ATOM 4413 CG2 ILE B 197 15.198 -18.115 48.240 1.00 16.38 C

ATOM 4414 C ILE B 197 13.750 -16.353 50.078 1.00 15.99 C

ATOM 4415 O ILE B 197 13.071 -15.863 49.172 1.00 15.75 O

ATOM 4416 N PRO B 198 13.191 -16.963 51.152 1.00 15.49 N

ATOM 4417 CA PRO B 198 11.724 -17.098 51.206 1.00 15.15 C

ATOM 4418 CB PRO B 198 11.478 -17.708 52.594 1.00 15.03 C

ATOM 4419 CG PRO B 198 12.736 -18.451 52.894 1.00 15.44 C

ATOM 4420 CD PRO B 198 13.824 -17.571 52.339 1.00 15.54 C

ATOM 4421 C PRO B 198 10.949 -15.779 51.053 1.00 14.68 C

ATOM 4422 O PRO B 198 9.990 -15.721 50.285 1.00 14.45 O

ATOM 4423 N GLN B 199 11.373 -14.734 51.761 1.00 14.36 N

ATOM 4424 CA GLN B 199 10.642 -13.467 51.746 1.00 14.20 C

ATOM 4425 CB GLN B 199 10.874 -12.672 53.037 1.00 14.34 C

ATOM 4426 CG GLN B 199 9.983 -11.414 53.194 1.00 14.76 C

ATOM 4427 CD GLN B 199 8.473 -11.707 53.168 1.00 15.01 C

ATOM 4428 OEl GLN B 199 7.807 -11.666 54.206 1.00 14.75 O

ATOM 4429 NE2 GLN B 199 7.933 -11.995 51.977 1.00 13.23 N

ATOM 4430 C GLN B 199 10.937 -12.612 50.514 1.00 13.83 C

ATOM 4431 O GLN B 199 10.014 -12.070 49.896 1.00 13.42 O

ATOM 4432 N LEU B 200 12.220 -12.505 50.170 1.00 13.43 N

ATOM 4433 CA LEU B 200 12.680 -11.709 49.029 1.00 13.15 C

ATOM 4434 CB LEU B 200 14.212 -11.761 48.927 1.00 13.22 C

ATOM 4435 CG LEU B 200 14.918 -10.927 47.850 1.00 13.17 C

ATOM 4436 CDl LEU B 200 14.897 -9.441 48.190 1.00 13.13 C

ATOM 4437 CD2 LEU B 200 16.347 -11.410 47.664 1.00 12.73 C

ATOM 4438 C LEU B 200 12.048 -12.161 47.712 1.00 13.20 C

ATOM 4439 O LEU B 200 11.674 -11.328 46.875 1.00 13.04 O

ATOM 4440 N SER B 201 11.929 -13.479 47.544 1.00 13.03 N

ATOM 4441 CA SER B 201 11.388 -14.078 46.325 1.00 12.74 C

ATOM 4442 CB SER B 201 11.571 -15.597 46.350 1.00 12.99 C

ATOM 4443 OG SER B 201 12.945 -15.948 46.382 1.00 12.27 O

ATOM 4444 C SER B 201 9.919 -13.722 46.069 1.00 12.79 C

ATOM 4445 O SER B 201 9.491 -13.648 44.916 1.00 12.42 O

ATOM 4446 N GLN B 202 9.159 -13.501 47.143 1.00 12.62 N

ATOM 4447 CA GLN B 202 7.755 -13.093 47.033 1.00 12.69 C

ATOM 4448 CB GLN B 202 7.043 -13.188 48.394 1.00 12.78 C

ATOM 4449 CG GLN B 202 7.037 -14.591 49.011 1.00 13.21 C

ATOM 4450 CD GLN B 202 6.428 -15.644 48.095 1.00 14.79 C

ATOM 4451 OEl GLN B 202 5.425 -15.399 47.418 1.00 15.45 O

ATOM 4452 NE2 GLN B 202 7.038 -16.823 48.068 1.00 15.28 N W2025-7029WO / AM102903-PCT

ATOM 4453 C GLN B 202 7.589 -11.689 46.449 1.00 12.61 C

ATOM 4454 O GLN B 202 6.636 -11.429 45.708 1.00 12.42 O

ATOM 4455 N TYR B 203 8.521 -10.794 46.778 1.00 12.65 N

ATOM 4456 CA TYR B 203 8.427 -9.389 46.364 1.00 12.97 C

ATOM 4457 CB TYR B 203 9.060 -8.466 47.415 1.00 13.43 C

ATOM 4458 CG TYR B 203 8.373 -8.484 48.769 1.00 14.41 C

ATOM 4459 CDl TYR B 203 9.102 -8.699 49.938 1.00 14.98 C

ATOM 4460 CEl TYR B 203 8.476 -8.713 51.187 1.00 15.60 C

ATOM 4461 CZ TYR B 203 7.108 -8.509 51.272 1.00 15.10 C

ATOM 4462 OH TYR B 203 6.483 -8.523 52.500 1.00 16.04 O

ATOM 4463 CE2 TYR B 203 6.359 -8.295 50.126 1.00 16.02 C

ATOM 4464 CD2 TYR B 203 6.996 -8.280 48.881 1.00 15.65 C

ATOM 4465 C TYR B 203 9.025 -9.105 44.981 1.00 12.50 C

ATOM 4466 O TYR B 203 8.538 -8.227 44.258 1.00 12.44 O

ATOM 4467 N LEU B 204 10.082 -9.835 44.624 1.00 11.90 N

ATOM 4468 CA LEU B 204 10.709 -9.693 43.306 1.00 11.42 C

ATOM 4469 CB LEU B 204 12.087 -10.369 43.276 1.00 11.28 C

ATOM 4470 CG LEU B 204 13.252 -9.797 44.095 1.00 11.32 C

ATOM 4471 CDl LEU B 204 14.407 -10.784 44.102 1.00 10.81 C

ATOM 4472 CD2 LEU B 204 13.706 -8.444 43.554 1.00 10.53 C

ATOM 4473 C LEU B 204 9.825 -10.285 42.214 1.00 11.09 C

ATOM 4474 O LEU B 204 9.130 -11.269 42.446 1.00 11.33 O

ATOM 4475 N ASP B 205 9.861 -9.683 41.027 1.00 10.87 N

ATOM 4476 CA ASP B 205 9.132 -10.191 39.864 1.00 10.50 C

ATOM 4477 CB ASP B 205 8.881 -9.061 38.865 1.00 10.50 C

ATOM 4478 CG ASP B 205 7.829 -8.089 39.347 1.00 11.14 C

ATOM 4479 ODl ASP B 205 6.689 -8.536 39.604 1.00 12.17 O

ATOM 4480 OD2 ASP B 205 8.141 -6.884 39.469 1.00 10.60 O

ATOM 4481 C ASP B 205 9.874 -11.331 39.174 1.00 10.12 C

ATOM 4482 O ASP B 205 9.264 -12.299 38.717 1.00 9.97 O

ATOM 4483 N TYR B 206 11.190 -11.186 39.071 1.00 9.94 N

ATOM 4484 CA TYR B 206 12.046 -12.222 38.513 1.00 9.69 C

ATOM 4485 CB TYR B 206 12.279 -12.010 37.012 1.00 10.15 C

ATOM 4486 CG TYR B 206 11.039 -12.239 36.179 1.00 10.83 C

ATOM 4487 CDl TYR B 206 10.309 -11.167 35.675 1.00 11.39 C

ATOM 4488 CEl TYR B 206 9.155 -11.375 34.908 1.00 12.68 C

ATOM 4489 CZ TYR B 206 8.727 -12.672 34.653 1.00 12.44 C

ATOM 4490 OH TYR B 206 7.591 -12.892 33.901 1.00 12.41 O

ATOM 4491 CE2 TYR B 206 9.436 -13.752 35.151 1.00 12.14 C

ATOM 4492 CD2 TYR B 206 10.585 -13.531 35.911 1.00 11.34 C

ATOM 4493 C TYR B 206 13.359 -12.254 39.260 1.00 9.19 C

ATOM 4494 O TYR B 206 13.796 -11.242 39.812 1.00 8.70 O

ATOM 4495 N ILE B 207 13.960 -13.440 39.295 1.00 8.82 N

ATOM 4496 CA ILE B 207 15.225 -13.665 39.971 1.00 8.50 C

ATOM 4497 CB ILE B 207 15.072 -14.681 41.138 1.00 8.59 C

ATOM 4498 CGl ILE B 207 13.968 -14.225 42.104 1.00 8.35 C

ATOM 4499 CDl ILE B 207 13.453 -15.327 43.034 1.00 8.73 C

ATOM 4500 CG2 ILE B 207 16.390 -14.853 41.898 1.00 8.32 C

ATOM 4501 C ILE B 207 16.203 -14.152 38.908 1.00 8.37 C

ATOM 4502 O ILE B 207 16.088 -15.274 38.407 1.00 8.62 O

ATOM 4503 N HIS B 208 17.137 -13.279 38.545 1.00 8.10 N

ATOM 4504 CA HIS B 208 18.126 -13.569 37.517 1.00 8.06 C

ATOM 4505 CB HIS B 208 18.484 -12.295 36.740 1.00 7.83 C

ATOM 4506 CG HIS B 208 17.302 -11.576 36.163 1.00 7.43 C

ATOM 4507 NDl HIS B 208 17.044 -10.246 36.423 1.00 6.00 N

ATOM 4508 CEl HIS B 208 15.949 -9.879 35.779 1.00 6.30 C

ATOM 4509 NE2 HIS B 208 15.487 -10.922 35.112 1.00 7.57 N

ATOM 4510 CD2 HIS B 208 16.318 -11.996 35.333 1.00 7.05 C

ATOM 4511 C HIS B 208 19.374 -14.148 38.168 1.00 7.98 C

ATOM 4512 O HIS B 208 20.162 -13.415 38.762 1.00 7.87 O

ATOM 4513 N VAL B 209 19.547 -15.463 38.062 1.00 7.81 N

ATOM 4514 CA VAL B 209 20.631 -16.138 38.783 1.00 7.98 C

ATOM 4515 CB VAL B 209 20.220 -17.545 39.282 1.00 7.93 C W2025-7029WO / AM102903-PCT

ATOM 4516 CGl VAL B 209 21.271 -18.101 40.230 1.00 8.16 C

ATOM 4517 CG2 VAL B 209 18.864 -17.482 39.983 1.00 7.36 C

ATOM 4518 C VAL B 209 21.878 -16.206 37.909 1.00 8.12 C

ATOM 4519 O VAL B 209 21.836 -16.725 36.795 1.00 7.95 O

ATOM 4520 N MET B 210 22.979 -15.671 38.429 1.00 8.38 N

ATOM 4521 CA MET B 210 24.209 -15.506 37.655 1.00 8.78 C

ATOM 4522 CB MET B 210 25.028 -14.333 38.206 1.00 8.72 C

ATOM 4523 CG MET B 210 24.316 -12.986 38.071 1.00 8.74 C

ATOM 4524 SD MET B 210 25.257 -11.541 38.619 1.00 9.93

ATOM 4525 CE MET B 210 24.998 -11.602 40.387 1.00 8.33 C

ATOM 4526 C MET B 210 25.025 -16.803 37.579 1.00 8.72 C

ATOM 4527 O MET B 210 26.160 -16.872 38.069 1.00 9.17 O

ATOM 4528 N THR B 211 24.433 -17.819 36.948 1.00 8.37 N

ATOM 4529 CA THR B 211 25.036 -19.152 36.826 1.00 8.27 C

ATOM 4530 CB THR B 211 23.977 -20.247 36.561 1.00 8.08 C

ATOM 4531 OGl THR B 211 23.137 -19.849 35.472 1.00 8.42 O

ATOM 4532 CG2 THR B 211 23.115 -20.488 37.797 1.00 8.85 C

ATOM 4533 C THR B 211 26.114 -19.181 35.736 1.00 8.02 C

ATOM 4534 O THR B 211 25.955 -19.820 34.684 1.00 8.43 O

ATOM 4535 N TYR B 212 27.195 -18.455 36.005 1.00 7.96 N

ATOM 4536 CA TYR B 212 28.384 -18.388 35.151 1.00 7.67 C

ATOM 4537 CB TYR B 212 28.150 -17.531 33.890 1.00 7.26 C

ATOM 4538 CG TYR B 212 27.311 -16.275 34.074 1.00 7.48 C

ATOM 4539 CDl TYR B 212 27.822 -15.153 34.730 1.00 6.65 C

ATOM 4540 CEl TYR B 212 27.053 -13.992 34.883 1.00 6.92 C

ATOM 4541 CZ TYR B 212 25.766 -13.946 34.366 1.00 6.58 C

ATOM 4542 OH TYR B 212 25.003 -12.801 34.516 1.00 7.75 O

ATOM 4543 CE2 TYR B 212 25.241 -15.040 33.700 1.00 6.19 C

ATOM 4544 CD2 TYR B 212 26.012 -16.194 33.549 1.00 6.45 C

ATOM 4545 C TYR B 212 29.564 -17.876 35.981 1.00 7.61 C

ATOM 4546 O TYR B 212 29.398 -17.571 37.163 1.00 7.65 O

ATOM 4547 N ASP B 213 30.745 -17.779 35.366 1.00 7.66 N

ATOM 4548 CA ASP B 213 32.009 -17.580 36.104 1.00 7.84 C

ATOM 4549 CB ASP B 213 32.160 -16.144 36.639 1.00 7.86 C

ATOM 4550 CG ASP B 213 31.841 -15.078 35.599 1.00 8.09 C

ATOM 4551 ODl ASP B 213 32.408 -15.110 34.484 1.00 8.63 O

ATOM 4552 OD2 ASP B 213 31.027 -14.192 35.914 1.00 8.08 O

ATOM 4553 C ASP B 213 32.141 -18.598 37.253 1.00 7.94 C

ATOM 4554 O ASP B 213 32.573 -18.263 38.358 1.00 7.70 O

ATOM 4555 N LEU B 214 31.753 -19.841 36.981 1.00 8.11 N

ATOM 4556 CA LEU B 214 31.782 -20.884 38.001 1.00 8.37 C

ATOM 4557 CB LEU B 214 30.737 -21.960 37.707 1.00 8.42 C

ATOM 4558 CG LEU B 214 29.282 -21.449 37.672 1.00 9.16 C

ATOM 4559 CDl LEU B 214 28.322 -22.571 37.300 1.00 9.79 C

ATOM 4560 CD2 LEU B 214 28.865 -20.803 38.988 1.00 9.36 C

ATOM 4561 C LEU B 214 33.189 -21.456 38.140 1.00 8.50 C

ATOM 4562 O LEU B 214 33.588 -21.877 39.227 1.00 8.52 O

ATOM 4563 N HIS B 215 33.933 -21.439 37.033 1.00 8.33 N

ATOM 4564 CA HIS B 215 35.368 -21.719 37.033 1.00 8.28 C

ATOM 4565 CB HIS B 215 35.660 -23.114 36.480 1.00 8.10 C

ATOM 4566 CG HIS B 215 35.069 -24.223 37.293 1.00 8.76 C

ATOM 4567 NDl HIS B 215 35.541 -24.562 38.544 1.00 8.87 N

ATOM 4568 CEl HIS B 215 34.837 -25.576 39.014 1.00 9.38 C

ATOM 4569 NE2 HIS B 215 33.928 -25.906 38.115 1.00 9.61 N

ATOM 4570 CD2 HIS B 215 34.050 -25.073 37.029 1.00 8.35 C

ATOM 4571 C HIS B 215 36.127 -20.679 36.216 1.00 8.15 C

ATOM 4572 O HIS B 215 35.557 -20.032 35.334 1.00 7.92 O

ATOM 4573 N GLY B 216 37.413 -20.527 36.528 1.00 7.98 N

ATOM 4574 CA GLY B 216 38.298 -19.594 35.838 1.00 8.27 C

ATOM 4575 C GLY B 216 39.724 -19.704 36.342 1.00 8.49 C

ATOM 4576 O GLY B 216 40.006 -20.464 37.270 1.00 8.30 O

ATOM 4577 N SER B 217 40.617 -18.928 35.732 1.00 8.97 N

ATOM 4578 CA SER B 217 42.062 -19.033 35.969 1.00 9.19 C W2025-7029WO / AM102903-PCT

ATOM 4579 CB SER B 217 42.831 -18.125 35.004 1.00 9.04 C

ATOM 4580 OG SER B 217 42.511 -16.758 35.215 1.00 8.55 O

ATOM 4581 C SER B 217 42.475 -18.736 37.410 1.00 9.46 C

ATOM 4582 O SER B 217 43.593 -19.044 37.812 1.00 9.71 O

ATOM 4583 N TRP B 218 41.566 -18.142 38.178 1.00 9.85 N

ATOM 4584 CA TRP B 218 41.803 -17.863 39.583 1.00 10.14 C

ATOM 4585 CB TRP B 218 40.673 -17.004 40.167 1.00 10.30 C

ATOM 4586 CG TRP B 218 39.297 -17.587 40.024 1.00 10.34 C

ATOM 4587 CDl TRP B 218 38.701 -18.495 40.852 1.00 10.68 C

ATOM 4588 NEl TRP B 218 37.431 -18.787 40.404 1.00 10.72 N

ATOM 4589 CE2 TRP B 218 37.182 -18.059 39.269 1.00 10.52 C

ATOM 4590 CD2 TRP B 218 38.337 -17.288 38.999 1.00 10.72 C

ATOM 4591 CE3 TRP B 218 38.345 -16.450 37.872 1.00 11.23 C

ATOM 4592 CZ3 TRP B 218 37.200 -16.406 37.061 1.00 10.77 C

ATOM 4593 CH2 TRP B 218 36.065 -17.184 37.363 1.00 10.28 C

ATOM 4594 CZ2 TRP B 218 36.038 -18.017 38.453 1.00 10.33 C

ATOM 4595 C TRP B 218 41.988 -19.141 40.395 1.00 10.46 C

ATOM 4596 O TRP B 218 42.573 -19.110 41.473 1.00 10.38 O

ATOM 4597 N GLU B 219 41.505 -20.260 39.853 1.00 10.88 N

ATOM 4598 CA GLU B 219 41.623 -21.573 40.497 1.00 11.25 C

ATOM 4599 CB GLU B 219 40.455 -22.473 40.091 1.00 11.15 C

ATOM 4600 CG GLU B 219 39.119 -22.094 40.730 1.00 12.00 C

ATOM 4601 CD GLU B 219 37.945 -22.839 40.113 1.00 12.58 C

ATOM 4602 OEl GLU B 219 37.870 -22.905 38.868 1.00 15.07 O

ATOM 4603 OE2 GLU B 219 37.089 -23.349 40.870 1.00 15.13 O

ATOM 4604 C GLU B 219 42.953 -22.288 40.228 1.00 10.98 C

ATOM 4605 O GLU B 219 43.319 -23.213 40.958 1.00 10.71 O

ATOM 4606 N GLY B 220 43.666 -21.873 39.183 1.00 10.84 N

ATOM 4607 CA GLY B 220 44.948 -22.497 38.833 1.00 10.77 C

ATOM 4608 C GLY B 220 44.844 -23.746 37.969 1.00 10.75 C

ATOM 4609 O GLY B 220 45.855 -24.378 37.663 1.00 10.60 O

ATOM 4610 N TYR B 221 43.621 -24.097 37.578 1.00 10.91 N

ATOM 4611 CA TYR B 221 43.353 -25.246 36.708 1.00 11.11 C

ATOM 4612 CB TYR B 221 42.936 -26.487 37.520 1.00 12.05 C

ATOM 4613 CG TYR B 221 43.934 -26.869 38.579 1.00 13.49 C

ATOM 4614 CDl TYR B 221 43.821 -26.371 39.877 1.00 14.64 C

ATOM 4615 CEl TYR B 221 44.753 -26.703 40.858 1.00 15.51 C

ATOM 4616 CZ TYR B 221 45.813 -27.536 40.538 1.00 15.01 C

ATOM 4617 OH TYR B 221 46.729 -27.864 41.513 1.00 15.70 O

ATOM 4618 CE2 TYR B 221 45.950 -28.042 39.252 1.00 14.98 C

ATOM 4619 CD2 TYR B 221 45.014 -27.703 38.279 1.00 14.03 C

ATOM 4620 C TYR B 221 42.248 -24.895 35.728 1.00 10.46 C

ATOM 4621 O TYR B 221 41.401 -24.049 36.029 1.00 9.91 O

ATOM 4622 N THR B 222 42.257 -25.551 34.564 1.00 9.83 N

ATOM 4623 CA THR B 222 41.200 -25.361 33.569 1.00 9.28 C

ATOM 4624 CB THR B 222 41.500 -26.075 32.229 1.00 9.11 C

ATOM 4625 OGl THR B 222 41.654 -27.480 32.453 1.00 9.34 O

ATOM 4626 CG2 THR B 222 42.764 -25.527 31.583 1.00 8.06 C

ATOM 4627 C THR B 222 39.857 -25.854 34.106 1.00 9.42 C

ATOM 4628 O THR B 222 39.775 -26.905 34.748 1.00 9.44 O

ATOM 4629 N GLY B 223 38.812 -25.080 33.840 1.00 9.17 N

ATOM 4630 CA GLY B 223 37.450 -25.452 34.201 1.00 8.95 C

ATOM 4631 C GLY B 223 36.455 -24.694 33.344 1.00 8.80 C

ATOM 4632 O GLY B 223 36.810 -23.713 32.683 1.00 8.10 O

ATOM 4633 N GLU B 224 35.202 -25.144 33.365 1.00 8.81 N

ATOM 4634 CA GLU B 224 34.167 -24.578 32.505 1.00 8.77 C

ATOM 4635 CB GLU B 224 33.113 -25.639 32.160 1.00 8.90 C

ATOM 4636 CG GLU B 224 33.620 -26.745 31.243 1.00 8.17 C

ATOM 4637 CD GLU B 224 33.748 -26.300 29.792 1.00 7.96 C

ATOM 4638 OEl GLU B 224 33.427 -25.134 29.495 1.00 7.24 O

ATOM 4639 OE2 GLU B 224 34.165 -27.124 28.948 1.00 8.01 O

ATOM 4640 C GLU B 224 33.503 -23.342 33.107 1.00 8.94 C

ATOM 4641 O GLU B 224 33.271 -23.274 34.315 1.00 9.14 O W2025-7029WO / AM102903-PCT

ATOM 4642 N ASN B 225 33.205 -22.366 32.251 1.00 9.05 N

ATOM 4643 CA ASN B 225 32.504 -21.145 32.661 1.00 9.24 C

ATOM 4644 CB ASN B 225 32.328 -20.218 31.448 1.00 9.11 C

ATOM 4645 CG ASN B 225 31.777 -18.843 31.813 1.00 8.85 C

ATOM 4646 ODl ASN B 225 31.981 -18.339 32.914 1.00 8.46 O

ATOM 4647 ND2 ASN B 225 31.087 -18.223 30.864 1.00 7.78 N

ATOM 4648 C ASN B 225 31.151 -21.459 33.310 1.00 9.29 C

ATOM 4649 O ASN B 225 30.826 -20.945 34.383 1.00 9.51 O

ATOM 4650 N SER B 226 30.378 -22.324 32.665 1.00 9.41 N

ATOM 4651 CA SER B 226 29.018 -22.611 33.113 1.00 9.60 C

ATOM 4652 CB SER B 226 28.037 -21.655 32.426 1.00 9.56 C

ATOM 4653 OG SER B 226 26.740 -21.742 32.986 1.00 9.98 O

ATOM 4654 C SER B 226 28.631 -24.073 32.861 1.00 9.70 C

ATOM 4655 O SER B 226 27.763 -24.356 32.029 1.00 9.56 O

ATOM 4656 N PRO B 227 29.262 -25.014 33.593 1.00 10.07 N

ATOM 4657 CA PRO B 227 28.901 -26.426 33.432 1.00 10.46 C

ATOM 4658 CB PRO B 227 29.921 -27.150 34.322 1.00 10.31 C

ATOM 4659 CG PRO B 227 30.341 -26.149 35.335 1.00 9.97 C

ATOM 4660 CD PRO B 227 30.308 -24.826 34.619 1.00 10.06 C

ATOM 4661 C PRO B 227 27.472 -26.698 33.921 1.00 11.07 C

ATOM 4662 O PRO B 227 27.064 -26.140 34.943 1.00 11.27 O

ATOM 4663 N LEU B 228 26.719 -27.526 33.193 1.00 11.94 N

ATOM 4664 CA LEU B 228 25.337 -27.843 33.581 1.00 12.71 C

ATOM 4665 CB LEU B 228 24.540 -28.433 32.406 1.00 12.59 C

ATOM 4666 CG LEU B 228 23.083 -28.894 32.625 1.00 12.32 C

ATOM 4667 CDl LEU B 228 22.199 -27.810 33.267 1.00 12.19 C

ATOM 4668 CD2 LEU B 228 22.468 -29.363 31.316 1.00 12.36 C

ATOM 4669 C LEU B 228 25.264 -28.761 34.808 1.00 13.71 C

ATOM 4670 O LEU B 228 24.460 -28.520 35.717 1.00 13.63 O

ATOM 4671 N TYR B 229 26.108 -29.798 34.818 1.00 14.46 N

ATOM 4672 CA TYR B 229 26.144 -30.796 35.890 1.00 15.24 C

ATOM 4673 CB TYR B 229 25.768 -32.182 35.351 1.00 15.10 C

ATOM 4674 CG TYR B 229 24.442 -32.258 34.629 1.00 14.87 C

ATOM 4675 CDl TYR B 229 23.238 -32.075 35.312 1.00 14.85 C

ATOM 4676 CEl TYR B 229 22.011 -32.151 34.646 1.00 14.92 C

ATOM 4677 CZ TYR B 229 21.987 -32.429 33.289 1.00 14.69 C

ATOM 4678 OH TYR B 229 20.782 -32.508 32.630 1.00 14.75 O

ATOM 4679 CE2 TYR B 229 23.170 -32.626 32.590 1.00 14.35 C

ATOM 4680 CD2 TYR B 229 24.390 -32.540 33.263 1.00 14.92 C

ATOM 4681 C TYR B 229 27.528 -30.877 36.524 1.00 15.82 C

ATOM 4682 O TYR B 229 28.522 -30.497 35.904 1.00 16.02 O

ATOM 4683 N LYS B 230 27.584 -31.386 37.754 1.00 16.80 N

ATOM 4684 CA LYS B 230 28.848 -31.594 38.476 1.00 17.68 C

ATOM 4685 CB LYS B 230 28.583 -31.972 39.942 1.00 17.77 C

ATOM 4686 CG LYS B 230 27.974 -33.358 40.169 1.00 18.32 C

ATOM 4687 CD LYS B 230 27.548 -33.521 41.620 1.00 18.63 C

ATOM 4688 CE LYS B 230 27.584 -34.973 42.058 1.00 20.73 C

ATOM 4689 NZ LYS B 230 27.318 -35.102 43.526 1.00 21.85 N

ATOM 4690 C LYS B 230 29.753 -32.636 37.811 1.00 17.89 C

ATOM 4691 O LYS B 230 29.273 -33.568 37.157 1.00 18.52 O

ATOM 4692 N SER B 237 32.416 -28.754 48.441 1.00 30.75 N

ATOM 4693 CA SER B 237 32.136 -27.408 47.944 1.00 30.63 C

ATOM 4694 CB SER B 237 33.003 -26.366 48.666 1.00 30.83 C

ATOM 4695 OG SER B 237 34.378 -26.526 48.349 1.00 31.23 O

ATOM 4696 C SER B 237 32.321 -27.305 46.428 1.00 30.42 C

ATOM 4697 O SER B 237 31.787 -26.390 45.793 1.00 30.44 O

ATOM 4698 N ASN B 238 33.074 -28.244 45.855 1.00 30.07 N

ATOM 4699 CA ASN B 238 33.284 -28.293 44.407 1.00 29.59 C

ATOM 4700 CB ASN B 238 34.518 -29.135 44.059 1.00 29.94 C

ATOM 4701 CG ASN B 238 35.830 -28.451 44.437 1.00 30.91 C

ATOM 4702 ODl ASN B 238 35.901 -27.224 44.566 1.00 31.99 O

ATOM 4703 ND2 ASN B 238 36.883 -29.251 44.606 1.00 31.53 N

ATOM 4704 C ASN B 238 32.061 -28.808 43.653 1.00 28.92 C W2025-7029WO / AM102903-PCT

ATOM 4705 O ASN B 238 31.885 -28.506 42.471 1.00 29.01 O

ATOM 4706 N ALA B 239 31.219 -29.575 44.346 1.00 27.98 N

ATOM 4707 CA ALA B 239 29.999 -30.144 43.764 1.00 26.97 C

ATOM 4708 CB ALA B 239 29.501 -31.307 44.618 1.00 27.16 C

ATOM 4709 C ALA B 239 28.885 -29.107 43.569 1.00 26.21 C

ATOM 4710 O ALA B 239 27.872 -29.384 42.922 1.00 25.92 O

ATOM 4711 N TYR B 240 29.082 -27.915 44.129 1.00 25.32 N

ATOM 4712 CA TYR B 240 28.109 -26.829 44.014 1.00 24.41 C

ATOM 4713 CB TYR B 240 28.195 -25.890 45.225 1.00 24.77 C

ATOM 4714 CG TYR B 240 28.148 -26.550 46.596 1.00 25.15 C

ATOM 4715 CDl TYR B 240 27.502 -27.774 46.796 1.00 25.08 C

ATOM 4716 CEl TYR B 240 27.449 -28.363 48.052 1.00 25.99 C

ATOM 4717 CZ TYR B 240 28.041 -27.728 49.132 1.00 25.85 C

ATOM 4718 OH TYR B 240 27.988 -28.312 50.377 1.00 26.19 O

ATOM 4719 CE2 TYR B 240 28.683 -26.510 48.967 1.00 26.15 C

ATOM 4720 CD2 TYR B 240 28.729 -25.926 47.703 1.00 25.42 C

ATOM 4721 C TYR B 240 28.299 -26.011 42.732 1.00 23.65 C

ATOM 4722 O TYR B 240 27.389 -25.293 42.306 1.00 23.29 O

ATOM 4723 N LEU B 241 29.480 -26.127 42.126 1.00 22.46 N

ATOM 4724 CA LEU B 241 29.878 -25.246 41.029 1.00 21.48 C

ATOM 4725 CB LEU B 241 31.400 -25.042 41.022 1.00 21.57 C

ATOM 4726 CG LEU B 241 32.038 -24.453 42.290 1.00 21.46 C

ATOM 4727 CDl LEU B 241 33.557 -24.564 42.231 1.00 21.43 C

ATOM 4728 CD2 LEU B 241 31.609 -23.008 42.543 1.00 21.14 C

ATOM 4729 C LEU B 241 29.357 -25.700 39.665 1.00 20.83 C

ATOM 4730 O LEU B 241 30.129 -26.002 38.747 1.00 20.74 O

ATOM 4731 N ASN B 242 28.031 -25.744 39.552 1.00 19.88 N

ATOM 4732 CA ASN B 242 27.341 -26.085 38.308 1.00 19.07 C

ATOM 4733 CB ASN B 242 27.297 -27.607 38.104 1.00 19.11 C

ATOM 4734 CG ASN B 242 26.720 -28.342 39.299 1.00 18.95 C

ATOM 4735 ODl ASN B 242 25.510 -28.530 39.407 1.00 18.32 O

ATOM 4736 ND2 ASN B 242 27.590 -28.766 40.203 1.00 19.33 N

ATOM 4737 C ASN B 242 25.933 -25.495 38.296 1.00 18.72 C

ATOM 4738 O ASN B 242 25.378 -25.189 39.358 1.00 18.17 O

ATOM 4739 N VAL B 243 25.366 -25.339 37.099 1.00 18.25 N

ATOM 4740 CA VAL B 243 24.026 -24.762 36.926 1.00 18.06 C

ATOM 4741 CB VAL B 243 23.621 -24.680 35.424 1.00 18.01 C

ATOM 4742 CGl VAL B 243 22.184 -24.172 35.269 1.00 17.80 C

ATOM 4743 CG2 VAL B 243 24.585 -23.785 34.646 1.00 17.16 C

ATOM 4744 C VAL B 243 22.954 -25.529 37.718 1.00 18.31 C

ATOM 4745 O VAL B 243 22.120 -24.918 38.390 1.00 17.97 O

ATOM 4746 N ASP B 244 22.994 -26.861 37.642 1.00 18.65 N

ATOM 4747 CA ASP B 244 21.969 -27.703 38.268 1.00 18.97 C

ATOM 4748 CB ASP B 244 22.164 -29.191 37.934 1.00 19.20 C

ATOM 4749 CG ASP B 244 21.093 -30.082 38.572 1.00 20.42 C

ATOM 4750 ODl ASP B 244 20.245 -30.633 37.834 1.00 22.27 O

ATOM 4751 OD2 ASP B 244 21.087 -30.220 39.816 1.00 21.47 O

ATOM 4752 C ASP B 244 21.882 -27.508 39.779 1.00 18.76 C

ATOM 4753 O ASP B 244 20.783 -27.337 40.313 1.00 18.77 O

ATOM 4754 N TYR B 245 23.027 -27.545 40.461 1.00 18.28 N

ATOM 4755 CA TYR B 245 23.037 -27.385 41.911 1.00 18.09 C

ATOM 4756 CB TYR B 245 24.412 -27.677 42.517 1.00 18.24 C

ATOM 4757 CG TYR B 245 24.383 -27.638 44.031 1.00 18.42 C

ATOM 4758 CDl TYR B 245 24.120 -28.793 44.770 1.00 18.89 C

ATOM 4759 CEl TYR B 245 24.077 -28.764 46.157 1.00 19.06 C

ATOM 4760 CZ TYR B 245 24.285 -27.569 46.822 1.00 18.86 C

ATOM 4761 OH TYR B 245 24.242 -27.542 48.197 1.00 19.17 O

ATOM 4762 CE2 TYR B 245 24.539 -26.401 46.113 1.00 18.99 C

ATOM 4763 CD2 TYR B 245 24.586 -26.442 44.725 1.00 18.57 C

ATOM 4764 C TYR B 245 22.565 -25.997 42.339 1.00 17.75 C

ATOM 4765 O TYR B 245 21.790 -25.869 43.290 1.00 17.52 O

ATOM 4766 N VAL B 246 23.038 -24.971 41.633 1.00 17.19 N

ATOM 4767 CA VAL B 246 22 722 -23.579 41.962 1.00 16.77 C W2025-7029WO / AM102903-PCT

ATOM 4768 CB VAL B 246 23.595 -22.579 41.160 1.00 16.80 C

ATOM 4769 CGl VAL B 246 23.158 -21.142 41.433 1.00 16.09 C

ATOM 4770 CG2 VAL B 246 25.069 -22.759 41.504 1.00 16.13 C

ATOM 4771 C VAL B 246 21.236 -23.252 41.781 1.00 16.67 C

ATOM 4772 O VAL B 246 20.617 -22.668 42.675 1.00 16.66 O

ATOM 4773 N MET B 247 20.675 -23.635 40.634 1.00 16.56 N

ATOM 4774 CA MET B 247 19.258 -23.398 40.341 1.00 16.45 C

ATOM 4775 CB MET B 247 18.913 -23.756 38.890 1.00 16.06 C

ATOM 4776 CG MET B 247 19.530 -22.841 37.824 1.00 15.12 C

ATOM 4777 SD MET B 247 19.392 -21.059 38.122 1.00 12.97 S

ATOM 4778 CE MET B 247 17.620 -20.846 38.315 1.00 13.07 C

ATOM 4779 C MET B 247 18.340 -24.158 41.294 1.00 16.90 C

ATOM 4780 O MET B 247 17.309 -23.630 41.728 1.00 17.06 O

ATOM 4781 N ASN B 248 18.719 -25.393 41.617 1.00 16.78 N

ATOM 4782 CA ASN B 248 17.957 -26.188 42.572 1.00 17.00 C

ATOM 4783 CB ASN B 248 18.265 -27.682 42.432 1.00 16.66 C

ATOM 4784 CG ASN B 248 17.469 -28.331 41.313 1.00 16.83 C

ATOM 4785 ODl ASN B 248 16.243 -28.442 41.393 1.00 15.52 O

ATOM 4786 ND2 ASN B 248 18.162 -28.758 40.254 1.00 16.24 N

ATOM 4787 C ASN B 248 18.101 -25.709 44.014 1.00 17.09 C

ATOM 4788 O ASN B 248 17.142 -25.786 44.774 1.00 17.00 O

ATOM 4789 N TYR B 249 19.279 -25.190 44.368 1.00 17.53 N

ATOM 4790 CA TYR B 249 19.501 -24.574 45.683 1.00 18.08 C

ATOM 4791 CB TYR B 249 20.965 -24.150 45.874 1.00 18.35 C

ATOM 4792 CG TYR B 249 21.269 -23.668 47.283 1.00 18.92 C

ATOM 4793 CDl TYR B 249 21.766 -24.547 48.247 1.00 19.57 C

ATOM 4794 CEl TYR B 249 22.041 -24.118 49.543 1.00 19.55 C

ATOM 4795 CZ TYR B 249 21.804 -22.796 49.889 1.00 19.34 C

ATOM 4796 OH TYR B 249 22.075 -22.373 51.169 1.00 19.31 O

ATOM 4797 CE2 TYR B 249 21.305 -21.901 48.952 1.00 18.90 C

ATOM 4798 CD2 TYR B 249 21.041 -22.339 47.659 1.00 18.94 C

ATOM 4799 C TYR B 249 18.582 -23.375 45.928 1.00 18.33 C

ATOM 4800 O TYR B 249 18.032 -23.227 47.023 1.00 18.22 O

ATOM 4801 N TRP B 250 18.435 -22.523 44.914 1.00 18.48 N

ATOM 4802 CA TRP B 250 17.549 -21.362 44.987 1.00 18.83 C

ATOM 4803 CB TRP B 250 17.722 -20.450 43.766 1.00 18.43 C

ATOM 4804 CG TRP B 250 18.786 -19.422 43.978 1.00 18.15 C

ATOM 4805 CDl TRP B 250 20.094 -19.512 43.611 1.00 17.46 C

ATOM 4806 NEl TRP B 250 20.772 -18.382 43.991 1.00 17.63 N

ATOM 4807 CE2 TRP B 250 19.901 -17.533 44.623 1.00 17.86 C

ATOM 4808 CD2 TRP B 250 18.638 -18.159 44.635 1.00 17.68 C

ATOM 4809 CE3 TRP B 250 17.557 -17.493 45.230 1.00 17.78 C

ATOM 4810 CZ3 TRP B 250 17.773 -16.235 45.786 1.00 17.59 C

ATOM 4811 CH2 TRP B 250 19.045 -15.638 45.758 1.00 17.73 C

ATOM 4812 CZ2 TRP B 250 20.120 -16.270 45.188 1.00 17.84 C

ATOM 4813 C TRP B 250 16.096 -21.780 45.139 1.00 19.22 C

ATOM 4814 O TRP B 250 15.388 -21.262 46.007 1.00 19.52 O

ATOM 4815 N LYS B 251 15.671 -22.727 44.306 1.00 19.72 N

ATOM 4816 CA LYS B 251 14.322 -23.282 44.365 1.00 20.23 C

ATOM 4817 CB LYS B 251 14.086 -24.268 43.216 1.00 20.48 C

ATOM 4818 CG LYS B 251 12.651 -24.763 43.131 1.00 21.36 C

ATOM 4819 CD LYS B 251 12.493 -25.898 42.138 1.00 23.73 C

ATOM 4820 CE LYS B 251 11.083 -26.475 42.206 1.00 25.23 C

ATOM 4821 NZ LYS B 251 10.802 -27.394 41.071 1.00 26.43 N

ATOM 4822 C LYS B 251 14.024 -23.959 45.707 1.00 20.42 C

ATOM 4823 O LYS B 251 12.977 -23.708 46.314 1.00 20.66 O

ATOM 4824 N ASP B 252 14.949 -24.803 46.162 1.00 20.30 N

ATOM 4825 CA ASP B 252 14.760 -25.586 47.385 1.00 20.30 C

ATOM 4826 CB ASP B 252 15.857 -26.652 47.534 1.00 20.27 C

ATOM 4827 CG ASP B 252 15.701 -27.808 46.558 1.00 20.45 C

ATOM 4828 ODl ASP B 252 14.632 -27.948 45.922 1.00 20.96 O

ATOM 4829 OD2 ASP B 252 16.668 -28.585 46.424 1.00 21.66 O

ATOM 4830 C ASP B 252 14.721 -24.725 48.641 1.00 20.13 C W2025-7029WO / AM102903-PCT

ATOM 4831 O ASP B 252 14.178 -25.146 49.667 1.00 20.26 O

ATOM 4832 N ASN B 253 15.297 -23.528 48.555 1.00 19.69 N

ATOM 4833 CA ASN B 253 15.444 -22.656 49.714 1.00 19.33 C

ATOM 4834 CB ASN B 253 16.897 -22.187 49.839 1.00 19.49 C

ATOM 4835 CG ASN B 253 17.796 -23.243 50.451 1.00 20.56 C

ATOM 4836 ODl ASN B 253 17.924 -23.330 51.673 1.00 21.84 O

ATOM 4837 ND2 ASN B 253 18.424 -24.055 49.604 1.00 21.24 N

ATOM 4838 C ASN B 253 14.470 -21.472 49.782 1.00 18.91 C

ATOM 4839 O ASN B 253 14.647 -20.572 50.607 1.00 18.83 O

ATOM 4840 N GLY B 254 13.448 -21.474 48.925 1.00 18.46 N

ATOM 4841 CA GLY B 254 12.376 -20.476 49.014 1.00 18.38 C

ATOM 4842 C GLY B 254 11.908 -19.796 47.733 1.00 18.21 C

ATOM 4843 O GLY B 254 10.821 -19.208 47.707 1.00 18.30 O

ATOM 4844 N ALA B 255 12.719 -19.867 46.676 1.00 17.68 N

ATOM 4845 CA ALA B 255 12.401 -19.199 45.415 1.00 17.55 C

ATOM 4846 CB ALA B 255 13.689 -18.836 44.649 1.00 17.45 C

ATOM 4847 C ALA B 255 11.480 -20.046 44.544 1.00 17.33 C

ATOM 4848 O ALA B 255 11.819 -21.184 44.209 1.00 17.45 O

ATOM 4849 N PRO B 256 10.303 -19.501 44.181 1.00 17.20 N

ATOM 4850 CA PRO B 256 9.421 -20.201 43.247 1.00 16.89 C

ATOM 4851 CB PRO B 256 8.183 -19.301 43.151 1.00 16.97 C

ATOM 4852 CG PRO B 256 8.483 -18.076 43.888 1.00 17.06 C

ATOM 4853 CD PRO B 256 9.735 -18.228 44.663 1.00 17.24 C

ATOM 4854 C PRO B 256 10.074 -20.376 41.880 1.00 16.73 C

ATOM 4855 O PRO B 256 10.785 -19.477 41.413 1.00 16.23 O

ATOM 4856 N ALA B 257 9.833 -21.533 41.261 1.00 16.36 N

ATOM 4857 CA ALA B 257 10.470 -21.904 39.993 1.00 16.17 C

ATOM 4858 CB ALA B 257 10.126 -23.349 39.619 1.00 16.30 C

ATOM 4859 C ALA B 257 10.136 -20.955 38.840 1.00 16.01 C

ATOM 4860 O ALA B 257 11.010 -20.628 38.031 1.00 15.70 O

ATOM 4861 N GLU B 258 8.878 -20.516 38.776 1.00 15.59 N

ATOM 4862 CA GLU B 258 8.403 -19.626 37.710 1.00 15.49 C

ATOM 4863 CB GLU B 258 6.870 -19.478 37.787 1.00 15.95 C

ATOM 4864 CG GLU B 258 6.218 -18.546 36.740 1.00 18.38 C

ATOM 4865 CD GLU B 258 6.379 -19.018 35.292 1.00 21.11 C

ATOM 4866 OEl GLU B 258 6.381 -20.245 35.037 1.00 22.09 O

ATOM 4867 OE2 GLU B 258 6.493 -18.147 34.400 1.00 22.49 O

ATOM 4868 C GLU B 258 9.106 -18.255 37.712 1.00 14.66 C

ATOM 4869 O GLU B 258 9.194 -17.591 36.674 1.00 14.66 O

ATOM 4870 N LYS B 259 9.613 -17.849 38.874 1.00 13.60 N

ATOM 4871 CA LYS B 259 10.323 -16.576 39.012 1.00 12.87 C

ATOM 4872 CB LYS B 259 10.055 -15.959 40.386 1.00 12.54 C

ATOM 4873 CG LYS B 259 8.699 -15.291 40.519 1.00 11.96 C

ATOM 4874 CD LYS B 259 8.565 -14.627 41.882 1.00 11.00 C

ATOM 4875 CE LYS B 259 7.244 -13.884 42.021 1.00 10.61 C

ATOM 4876 NZ LYS B 259 7.211 -13.066 43.273 1.00 9.80 N

ATOM 4877 C LYS B 259 11.831 -16.717 38.795 1.00 12.49 C

ATOM 4878 O LYS B 259 12.522 -15.725 38.556 1.00 12.63 O

ATOM 4879 N LEU B 260 12.330 -17.947 38.886 1.00 11.94 N

ATOM 4880 CA LEU B 260 13.751 -18.227 38.693 1.00 11.42 C

ATOM 4881 CB LEU B 260 14.146 -19.535 39.390 1.00 11.62 C

ATOM 4882 CG LEU B 260 14.296 -19.493 40.914 1.00 11.70 C

ATOM 4883 CDl LEU B 260 14.424 -20.906 41.480 1.00 12.34 C

ATOM 4884 CD2 LEU B 260 15.486 -18.645 41.341 1.00 11.59 C

ATOM 4885 C LEU B 260 14.136 -18.268 37.215 1.00 10.93 C

ATOM 4886 O LEU B 260 13.523 -18.984 36.415 1.00 10.90 O

ATOM 4887 N ILE B 261 15.167 -17.497 36.877 1.00 10.31 N

ATOM 4888 CA ILE B 261 15.631 -17.325 35.503 1.00 9.54 C

ATOM 4889 CB ILE B 261 15.450 -15.843 35.042 1.00 9.57 C

ATOM 4890 CGl ILE B 261 14.018 -15.337 35.310 1.00 9.69 C

ATOM 4891 CDl ILE B 261 12.944 -15.869 34.364 1.00 8.95 C

ATOM 4892 CG2 ILE B 261 15.835 -15.652 33.576 1.00 9.65 C

ATOM 4893 C ILE B 261 17.102 -17.764 35.430 1.00 9.10 C W2025-7029WO / AM102903-PCT

ATOM 4894 O ILE B 261 17.944 -17.270 36.185 1.00 8.67 O

ATOM 4895 N VAL B 262 17.393 -18.710 34.538 1.00 8.37 N

ATOM 4896 CA VAL B 262 18.726 -19.322 34.439 1.00 7.82 C

ATOM 4897 CB VAL B 262 18.658 -20.741 33.788 1.00 7.79 C

ATOM 4898 CGl VAL B 262 20.042 -21.386 33.720 1.00 7.67 C

ATOM 4899 CG2 VAL B 262 17.685 -21.645 34.542 1.00 7.32 C

ATOM 4900 C VAL B 262 19.697 -18.430 33.654 1.00 7.60 C

ATOM 4901 O VAL B 262 19.343 -17.901 32.604 1.00 7.39 O

ATOM 4902 N GLY B 263 20.919 -18.276 34.168 1.00 7.19 N

ATOM 4903 CA GLY B 263 21.933 -17.434 33.529 1.00 6.75 C

ATOM 4904 C GLY B 263 22.745 -18.152 32.468 1.00 6.52 C

ATOM 4905 O GLY B 263 23.345 -19.195 32.733 1.00 6.62 O

ATOM 4906 N PHE B 264 22.756 -17.574 31.269 1.00 6.36 N

ATOM 4907 CA PHE B 264 23.442 -18.110 30.087 1.00 6.42 C

ATOM 4908 CB PHE B 264 22.447 -18.273 28.926 1.00 6.48 C

ATOM 4909 CG PHE B 264 21.576 -19.501 29.014 1.00 6.49 C

ATOM 4910 CDl PHE B 264 20.590 -19.616 29.993 1.00 6.70 C

ATOM 4911 CEl PHE B 264 19.789 -20.758 30.068 1.00 6.24 C

ATOM 4912 CZ PHE B 264 19.958 -21.781 29.141 1.00 6.31 C

ATOM 4913 CE2 PHE B 264 20.926 -21.668 28.158 1.00 6.37 C

ATOM 4914 CD2 PHE B 264 21.727 -20.533 28.096 1.00 7.00 C

ATOM 4915 C PHE B 264 24.532 -17.123 29.646 1.00 6.39 C

ATOM 4916 O PHE B 264 24.223 -15.973 29.333 1.00 6.23 O

ATOM 4917 N PRO B 265 25.807 -17.560 29.636 1.00 6.22 N

ATOM 4918 CA PRO B 265 26.905 -16.708 29.178 1.00 6.40 C

ATOM 4919 CB PRO B 265 28.075 -17.180 30.040 1.00 6.25 C

ATOM 4920 CG PRO B 265 27.781 -18.652 30.281 1.00 6.85 C

ATOM 4921 CD PRO B 265 26.292 -18.863 30.127 1.00 6.35 C

ATOM 4922 C PRO B 265 27.249 -16.843 27.686 1.00 6.28 C

ATOM 4923 O PRO B 265 27.485 -17.951 27.203 1.00 6.42 O

ATOM 4924 N THR B 266 27.288 -15.720 26.967 1.00 6.11 N

ATOM 4925 CA THR B 266 27.707 -15.723 25.555 1.00 5.89 C

ATOM 4926 CB THR B 266 26.853 -14.774 24.683 1.00 6.12 C

ATOM 4927 OGl THR B 266 26.872 -13.461 25.249 1.00 6.29 O

ATOM 4928 CG2 THR B 266 25.401 -15.268 24.581 1.00 6.00 C

ATOM 4929 C THR B 266 29.196 -15.377 25.431 1.00 5.98 C

ATOM 4930 O THR B 266 29.627 -14.715 24.487 1.00 5.47 O

ATOM 4931 N TYR B 267 29.970 -15.848 26.405 1.00 5.94 N

ATOM 4932 CA TYR B 267 31.414 -15.632 26.477 1.00 6.16 C

ATOM 4933 CB TYR B 267 31.729 -14.350 27.263 1.00 6.20 C

ATOM 4934 CG TYR B 267 31.381 -14.466 28.736 1.00 6.40 C

ATOM 4935 CDl TYR B 267 32.337 -14.882 29.672 1.00 6.91 C

ATOM 4936 CEl TYR B 267 32.013 -15.013 31.026 1.00 6.00 C

ATOM 4937 CZ TYR B 267 30.720 -14.727 31.442 1.00 6.53 C

ATOM 4938 OH TYR B 267 30.385 -14.857 32.764 1.00 6.77 O

ATOM 4939 CE2 TYR B 267 29.757 -14.313 30.529 1.00 5.47 C

ATOM 4940 CD2 TYR B 267 30.087 -14.195 29.189 1.00 5.49 C

ATOM 4941 C TYR B 267 32.000 -16.828 27.218 1.00 6.09 C

ATOM 4942 O TYR B 267 31.262 -17.605 27.829 1.00 6.40 O

ATOM 4943 N GLY B 268 33.321 -16.964 27.174 1.00 6.09 N

ATOM 4944 CA GLY B 268 34.014 -17.978 27.958 1.00 5.98 C

ATOM 4945 C GLY B 268 35.193 -17.410 28.721 1.00 5.97 C

ATOM 4946 O GLY B 268 35.585 -16.259 28.504 1.00 5.80 O

ATOM 4947 N HIS B 269 35.742 -18.211 29.635 1.00 5.94 N

ATOM 4948 CA HIS B 269 36.993 -17.863 30.321 1.00 5.82 C

ATOM 4949 CB HIS B 269 36.957 -18.256 31.798 1.00 5.79 C

ATOM 4950 CG HIS B 269 36.134 -17.342 32.650 1.00 5.71 C

ATOM 4951 NDl HIS B 269 36.634 -16.176 33.186 1.00 6.04 N

ATOM 4952 CEl HIS B 269 35.691 -15.579 33.891 1.00 5.13 C

ATOM 4953 NE2 HIS B 269 34.595 -16.313 33.827 1.00 5.89 N

ATOM 4954 CD2 HIS B 269 34.847 -17.422 33.057 1.00 5.72 C

ATOM 4955 C HIS B 269 38.162 -18.564 29.661 1.00 5.89 C

ATOM 4956 O HIS B 269 38.070 -19.750 29.328 1.00 5.97 O W2025-7029WO / AM102903-PCT

ATOM 4957 N ASN B 270 39.258 -17.835 29.466 1.00 5.87 N

ATOM 4958 CA ASN B 270 40.464 -18.441 28.914 1.00 5.98 C

ATOM 4959 CB ASN B 270 40.838 -17.845 27.542 1.00 6.06 C

ATOM 4960 CG ASN B 270 41.233 -16.378 27.608 1.00 6.16 C

ATOM 4961 ODl ASN B 270 41.399 -15.810 28.676 1.00 6.58 O

ATOM 4962 ND2 ASN B 270 41.393 -15.765 26.447 1.00 6.54 N

ATOM 4963 C ASN B 270 41.643 -18.503 29.907 1.00 6.16 C

ATOM 4964 O ASN B 270 41.641 -17.826 30.952 1.00 5.83 O

ATOM 4965 N PHE B 271 42.623 -19.341 29.573 1.00 6.15 N

ATOM 4966 CA PHE B 271 43.692 -19.733 30.483 1.00 6.35 C

ATOM 4967 CB PHE B 271 43.413 -21.116 31.109 1.00 6.19 C

ATOM 4968 CG PHE B 271 42.085 -21.253 31.830 1.00 6.13 C

ATOM 4969 CDl PHE B 271 40.879 -21.256 31.129 1.00 6.35 C

ATOM 4970 CEl PHE B 271 39.659 -21.418 31.787 1.00 6.10 C

ATOM 4971 CZ PHE B 271 39.637 -21.616 33.163 1.00 6.03 C

ATOM 4972 CE2 PHE B 271 40.834 -21.644 33.873 1.00 6.91 C

ATOM 4973 CD2 PHE B 271 42.052 -21.471 33.201 1.00 6.61 C

ATOM 4974 C PHE B 271 44.992 -19.878 29.698 1.00 6.62 C

ATOM 4975 O PHE B 271 44.969 -20.214 28.511 1.00 6.58 O

ATOM 4976 N ILE B 272 46.121 -19.673 30.374 1.00 6.80 N

ATOM 4977 CA ILE B 272 47.421 -20.112 29.850 1.00 7.07 C

ATOM 4978 CB ILE B 272 48.574 -19.088 30.137 1.00 7.07 C

ATOM 4979 CGl ILE B 272 48.271 -17.708 29.527 1.00 7.11 C

ATOM 4980 CDl ILE B 272 48.008 -17.704 28.022 1.00 6.66 C

ATOM 4981 CG2 ILE B 272 49.944 -19.632 29.665 1.00 6.66 C

ATOM 4982 C ILE B 272 47.767 -21.459 30.475 1.00 7.43 C

ATOM 4983 O ILE B 272 47.872 -21.567 31.699 1.00 7.63 O

ATOM 4984 N LEU B 273 47.936 -22.482 29.639 1.00 7.67 N

ATOM 4985 CA LEU B 273 48.344 -23.808 30.112 1.00 8.11 C

ATOM 4986 CB LEU B 273 48.133 -24.866 29.028 1.00 7.82 C

ATOM 4987 CG LEU B 273 46.721 -25.030 28.463 1.00 8.55 C

ATOM 4988 CDl LEU B 273 46.750 -25.892 27.201 1.00 8.18 C

ATOM 4989 CD2 LEU B 273 45.762 -25.607 29.513 1.00 7.76 C

ATOM 4990 C LEU B 273 49.803 -23.818 30.549 1.00 8.69 C

ATOM 4991 O LEU B 273 50.683 -23.372 29.803 1.00 8.46 O

ATOM 4992 N SER B 274 50.046 -24.332 31.754 1.00 9.46 N

ATOM 4993 CA SER B 274 51.404 -24.522 32.280 1.00 10.64 C

ATOM 4994 CB SER B 274 51.367 -25.085 33.706 1.00 10.56 C

ATOM 4995 OG SER B 274 50.668 -24.229 34.592 1.00 10.82 O

ATOM 4996 C SER B 274 52.208 -25.462 31.387 1.00 11.33 C

ATOM 4997 O SER B 274 53.415 -25.291 31.220 1.00 11.21 O

ATOM 4998 N ASN B 275 51.525 -26.464 30.837 1.00 12.18 N

ATOM 4999 CA ASN B 275 52.111 -27.395 29.874 1.00 13.05 C

ATOM 5000 CB ASN B 275 52.470 -28.734 30.548 1.00 13.80 C

ATOM 5001 CG ASN B 275 53.306 -29.652 29.652 1.00 15.54 C

ATOM 5002 ODl ASN B 275 53.032 -29.812 28.456 1.00 18.42 O

ATOM 5003 ND2 ASN B 275 54.323 -30.279 30.240 1.00 16.69 N

ATOM 5004 C ASN B 275 51.101 -27.602 28.756 1.00 12.73 C

ATOM 5005 O ASN B 275 49.975 -28.023 29.017 1.00 12.47 O

ATOM 5006 N PRO B 276 51.495 -27.285 27.508 1.00 12.79 N

ATOM 5007 CA PRO B 276 50.560 -27.345 26.384 1.00 12.86 C

ATOM 5008 CB PRO B 276 51.389 -26.824 25.199 1.00 13.11 C

ATOM 5009 CG PRO B 276 52.810 -27.050 25.601 1.00 13.33 C

ATOM 5010 CD PRO B 276 52.834 -26.834 27.086 1.00 13.03 C

ATOM 5011 C PRO B 276 50.007 -28.743 26.096 1.00 12.71 C

ATOM 5012 O PRO B 276 48.953 -28.851 25.474 1.00 12.48 O

ATOM 5013 N SER B 277 50.703 -29.792 26.546 1.00 12.63 N

ATOM 5014 CA SER B 277 50.219 -31.174 26.390 1.00 12.73 C

ATOM 5015 CB SER B 277 51.330 -32.199 26.675 1.00 12.57 C

ATOM 5016 OG SER B 277 51.739 -32.173 28.033 1.00 13.68 O

ATOM 5017 C SER B 277 48.978 -31.466 27.242 1.00 12.50 C

ATOM 5018 O SER B 277 48.105 -32.226 26.822 1.00 12.26 O

ATOM 5019 N ASN B 278 48.891 -30.864 28.428 1.00 12.30 N W2025-7029WO / AM102903-PCT

ATOM 5020 CA ASN B 278 47.710 -31.070 29.268 1.00 12.01 C

ATOM 5021 CB ASN B 278 48.020 -30.971 30.773 1.00 12.49 C

ATOM 5022 CG ASN B 278 46.958 -31.667 31.636 1.00 13.51 C

ATOM 5023 ODl ASN B 278 45.822 -31.905 31.194 1.00 14.98 O

ATOM 5024 ND2 ASN B 278 47.321 -31.991 32.868 1.00 14.43 N

ATOM 5025 C ASN B 278 46.560 -30.155 28.856 1.00 11.53 C

ATOM 5026 O ASN B 278 46.517 -28.967 29.201 1.00 11.24 O

ATOM 5027 N THR B 279 45.622 -30.741 28.118 1.00 10.68 N

ATOM 5028 CA THR B 279 44.594 -29.984 27.420 1.00 10.08 C

ATOM 5029 CB THR B 279 44.630 -30.294 25.914 1.00 9.98 C

ATOM 5030 OGl THR B 279 44.455 -31.705 25.711 1.00 10.08 O

ATOM 5031 CG2 THR B 279 45.960 -29.854 25.304 1.00 10.10 C

ATOM 5032 C THR B 279 43.193 -30.274 27.943 1.00 9.46 C

ATOM 5033 O THR B 279 42.218 -29.729 27.434 1.00 9.22 O

ATOM 5034 N GLY B 280 43.099 -31.137 28.949 1.00 9.10 N

ATOM 5035 CA GLY B 280 41.809 -31.549 29.492 1.00 8.64 C

ATOM 5036 C GLY B 280 41.239 -30.589 30.513 1.00 8.52 C

ATOM 5037 O GLY B 280 41.759 -29.488 30.705 1.00 8.02 O

ATOM 5038 N ILE B 281 40.148 -31.018 31.149 1.00 8.51 N

ATOM 5039 CA ILE B 281 39.571 -30.354 32.318 1.00 8.50 C

ATOM 5040 CB ILE B 281 38.129 -30.886 32.598 1.00 8.44 C

ATOM 5041 CGl ILE B 281 37.167 -30.533 31.446 1.00 9.20 C

ATOM 5042 CDl ILE B 281 36.721 -29.061 31.394 1.00 8.35 C

ATOM 5043 CG2 ILE B 281 37.598 -30.417 33.955 1.00 8.76 C

ATOM 5044 C ILE B 281 40.484 -30.626 33.515 1.00 8.26 C

ATOM 5045 O ILE B 281 40.953 -31.746 33.689 1.00 8.42 O

ATOM 5046 N GLY B 282 40.758 -29.590 34.309 1.00 8.15 N

ATOM 5047 CA GLY B 282 41.620 -29.704 35.488 1.00 8.01 C

ATOM 5048 C GLY B 282 43.109 -29.671 35.180 1.00 8.13 C

ATOM 5049 O GLY B 282 43.928 -30.083 36.011 1.00 7.96 O

ATOM 5050 N ALA B 283 43.456 -29.206 33.978 1.00 7.92 N

ATOM 5051 CA ALA B 283 44.852 -29.005 33.578 1.00 8.16 C

ATOM 5052 CB ALA B 283 44.946 -28.828 32.069 1.00 7.88 C

ATOM 5053 C ALA B 283 45.440 -27.786 34.287 1.00 8.28 C

ATOM 5054 O ALA B 283 44.774 -26.752 34.379 1.00 8.58 O

ATOM 5055 N PRO B 284 46.691 -27.895 34.786 1.00 8.72 N

ATOM 5056 CA PRO B 284 47.338 -26.773 35.483 1.00 8.86 C

ATOM 5057 CB PRO B 284 48.708 -27.339 35.887 1.00 8.97 C

ATOM 5058 CG PRO B 284 48.551 -28.824 35.830 1.00 9.18 C

ATOM 5059 CD PRO B 284 47.566 -29.080 34.732 1.00 8.75 C

ATOM 5060 C PRO B 284 47.525 -25.547 34.586 1.00 8.94 C

ATOM 5061 O PRO B 284 47.900 -25.679 33.415 1.00 8.50 O

ATOM 5062 N THR B 285 47.259 -24.370 35.147 1.00 9.17 N

ATOM 5063 CA THR B 285 47.369 -23.102 34.420 1.00 9.21 C

ATOM 5064 CB THR B 285 45.981 -22.505 34.099 1.00 9.03 C

ATOM 5065 OGl THR B 285 45.249 -22.300 35.310 1.00 8.85 O

ATOM 5066 CG2 THR B 285 45.196 -23.437 33.188 1.00 9.03 C

ATOM 5067 C THR B 285 48.211 -22.081 35.195 1.00 9.43 C

ATOM 5068 O THR B 285 48.304 -22.152 36.422 1.00 9.19 O

ATOM 5069 N SER B 286 48.820 -21.142 34.470 1.00 9.82 N

ATOM 5070 CA SER B 286 49.760 -20.178 35.062 1.00 10.36 C

ATOM 5071 CB SER B 286 51.087 -20.171 34.289 1.00 10.28 C

ATOM 5072 OG SER B 286 50.874 -19.956 32.901 1.00 11.37 O

ATOM 5073 C SER B 286 49.190 -18.759 35.174 1.00 10.37 C

ATOM 5074 O SER B 286 49.864 -17.841 35.663 1.00 10.83 O

ATOM 5075 N GLY B 287 47.944 -18.595 34.743 1.00 10.13 N

ATOM 5076 CA GLY B 287 47.255 -17.311 34.809 1.00 9.69 C

ATOM 5077 C GLY B 287 46.195 -17.190 33.730 1.00 9.47 C

ATOM 5078 O GLY B 287 45.958 -18.133 32.968 1.00 9.24 O

ATOM 5079 N ALA B 288 45.569 -16.017 33.667 1.00 9.31 N

ATOM 5080 CA ALA B 288 44.493 -15.732 32.720 1.00 8.96 C

ATOM 5081 CB ALA B Zoo 43.860 -14.388 33.049 1.00 9.05 C

ATOM 5082 C ALA B Zoo 45.001 -15.729 31.288 1.00 8.98 C W2025-7029WO / AM102903-PCT

ATOM 5083 O ALA B 288 46.143 -15.349 31.028 1.00 9.10 O

ATOM 5084 N GLY B 289 44.149 -16.162 30.364 1.00 8.51 N

ATOM 5085 CA GLY B 289 44.463 -16.112 28.945 1.00 8.45 C

ATOM 5086 C GLY B 289 44.442 -14.679 28.435 1.00 8.55 C

ATOM 5087 O GLY B 289 44.057 -13.753 29.172 1.00 8.32 O

ATOM 5088 N PRO B 290 44.866 -14.480 27.174 1.00 8.53 N

ATOM 5089 CA PRO B 290 45.001 -13.127 26.642 1.00 8.57 C

ATOM 5090 CB PRO B 290 45.778 -13.337 25.345 1.00 8.43 C

ATOM 5091 CG PRO B 290 45.442 -14.722 24.915 1.00 8.39 C

ATOM 5092 CD PRO B 290 45.243 -15.509 26.182 1.00 8.31 C

ATOM 5093 C PRO B 290 43.649 -12.495 26.345 1.00 8.71 C

ATOM 5094 O PRO B 290 42.698 -13.198 26.014 1.00 8.88 O

ATOM 5095 N ALA B 291 43.582 -11.175 26.485 1.00 9.01 N

ATOM 5096 CA ALA B 291 42.400 -10.406 26.111 1.00 8.98 C

ATOM 5097 CB ALA B 291 42.547 -8.967 26.562 1.00 9.01 C

ATOM 5098 C ALA B 291 42.223 -10.462 24.604 1.00 9.08 C

ATOM 5099 O ALA B 291 43.208 -10.410 23.855 1.00 9.26 O

ATOM 5100 N GLY B 292 40.971 -10.582 24.165 1.00 8.78 N

ATOM 5101 CA GLY B 292 40.647 -10.505 22.744 1.00 9.09 C

ATOM 5102 C GLY B 292 40.816 -9.082 22.233 1.00 9.14 C

ATOM 5103 O GLY B 292 40.833 -8.137 23.025 1.00 9.47 O

ATOM 5104 N PRO B 293 40.946 -8.915 20.905 1.00 9.46 N

ATOM 5105 CA PRO B 293 41.130 -7.576 20.348 1.00 9.63 C

ATOM 5106 CB PRO B 293 41.569 -7.848 18.903 1.00 9.79 C

ATOM 5107 CG PRO B 293 41.020 -9.185 18.577 1.00 9.38 C

ATOM 5108 CD PRO B 293 40.933 -9.960 19.862 1.00 9.46 C

ATOM 5109 C PRO B 293 39.857 -6.721 20.385 1.00 9.76 C

ATOM 5110 O PRO B 293 39.928 -5.507 20.202 1.00 9.56 O

ATOM 5111 N TYR B 294 38.713 -7.348 20.644 1.00 10.19 N

ATOM 5112 CA TYR B 294 37.431 -6.641 20.602 1.00 10.64 C

ATOM 5113 CB TYR B 294 36.414 -7.413 19.746 1.00 10.60 C

ATOM 5114 CG TYR B 294 36.817 -7.505 18.286 1.00 11.27 C

ATOM 5115 CDl TYR B 294 37.302 -8.696 17.749 1.00 10.66 C

ATOM 5116 CEl TYR B 294 37.691 -8.782 16.410 1.00 11.32 C

ATOM 5117 CZ TYR B 294 37.594 -7.658 15.596 1.00 11.78 C

ATOM 5118 OH TYR B 294 37.968 -7.734 14.275 1.00 10.70 O

ATOM 5119 CE2 TYR B 294 37.117 -6.460 16.109 1.00 11.32 C

ATOM 5120 CD2 TYR B 294 36.737 -6.387 17.448 1.00 11.67 C

ATOM 5121 C TYR B 294 36.866 -6.300 21.980 1.00 10.82 C

ATOM 5122 O TYR B 294 36.589 -5.135 22.257 1.00 11.09 O

ATOM 5123 N ALA B 295 36.704 -7.307 22.839 1.00 11.11 N

ATOM 5124 CA ALA B 295 36.138 -7.101 24.175 1.00 11.37 C

ATOM 5125 CB ALA B 295 35.518 -8.388 24.696 1.00 11.33 C

ATOM 5126 C ALA B 295 37.167 -6.552 25.166 1.00 11.76 C

ATOM 5127 O ALA B 295 36.797 -5.934 26.168 1.00 11.98 O

ATOM 5128 N LYS B 296 38.451 -6.786 24.878 1.00 11.76 N

ATOM 5129 CA LYS B 296 39.571 -6.211 25.636 1.00 11.94 C

ATOM 5130 CB LYS B 296 39.591 -4.672 25.519 1.00 12.07 C

ATOM 5131 CG LYS B 296 39.593 -4.133 24.079 1.00 12.62 C

ATOM 5132 CD LYS B 296 39.395 -2.610 24.024 1.00 12.79 C

ATOM 5133 CE LYS B 296 40.647 -1.865 24.489 1.00 14.68 C

ATOM 5134 NZ LYS B 296 40.621 -0.402 24.167 1.00 16.03 N

ATOM 5135 C LYS B 296 39.572 -6.641 27.109 1.00 11.72 C

ATOM 5136 O LYS B 296 39.934 -5.861 27.989 1.00 11.77 O

ATOM 5137 N GLU B 297 39.172 -7.884 27.370 1.00 11.24 N

ATOM 5138 CA GLU B 297 39.079 -8.378 28.742 1.00 11.10 C

ATOM 5139 CB GLU B 297 37.625 -8.708 29.113 1.00 11.01 C

ATOM 5140 CG GLU B 297 36.649 -7.525 29.018 1.00 11.22 C

ATOM 5141 CD GLU B 297 35.211 -7.882 29.390 1.00 11.50 C

ATOM 5142 OEl GLU B 297 34.978 -8.328 30.534 1.00 13.70 O

ATOM 5143 OE2 GLU B 297 34.306 -7.696 28.550 1.00 10.59 O

ATOM 5144 C GLU B 297 39.990 -9.592 28.947 1.00 10.76 C

ATOM 5145 O GLU B 297 39.750 -10.663 28.389 1.00 10.27 O W2025-7029WO / AM102903-PCT

ATOM 5146 N SER B 298 41.049 -9.401 29.731 1.00 10.76 N

ATOM 5147 CA SER B 298 41.949 -10.488 30.122 1.00 10.48 C

ATOM 5148 CB SER B 298 43.029 -9.954 31.075 1.00 10.77 C

ATOM 5149 OG SER B 298 43.615 -10.981 31.860 1.00 11.72 O

ATOM 5150 C SER B 298 41.144 -11.617 30.772 1.00 10.11 C

ATOM 5151 O SER B 298 40.246 -11.364 31.583 1.00 10.06 O

ATOM 5152 N GLY B 299 41.446 -12.853 30.384 1.00 9.67 N

ATOM 5153 CA GLY B 299 40.770 -14.028 30.934 1.00 9.36 C

ATOM 5154 C GLY B 299 39.395 -14.301 30.349 1.00 9.23 C

ATOM 5155 O GLY B 299 38.739 -15.260 30.750 1.00 9.47 O

ATOM 5156 N ILE B 300 38.974 -13.468 29.393 1.00 9.01 N

ATOM 5157 CA ILE B 300 37.631 -13.523 28.797 1.00 8.96 C

ATOM 5158 CB ILE B 300 36.734 -12.342 29.304 1.00 9.00 C

ATOM 5159 CGl ILE B 300 36.612 -12.324 30.836 1.00 9.80 C

ATOM 5160 CDl ILE B 300 35.716 -13.375 31.425 1.00 10.19 C

ATOM 5161 CG2 ILE B 300 35.352 -12.328 28.604 1.00 9.32 C

ATOM 5162 C ILE B 300 37.696 -13.424 27.272 1.00 8.37 C

ATOM 5163 O ILE B 300 38.407 -12.584 26.728 1.00 8.57 O

ATOM 5164 N TRP B 301 36.953 -14.282 26.585 1.00 7.96 N

ATOM 5165 CA TRP B 301 36.702 -14.089 25.162 1.00 7.45 C

ATOM 5166 CB TRP B 301 37.356 -15.180 24.312 1.00 7.58 C

ATOM 5167 CG TRP B 301 38.818 -14.992 23.985 1.00 7.71 C

ATOM 5168 CDl TRP B 301 39.526 -13.823 23.975 1.00 8.09 C

ATOM 5169 NEl TRP B 301 40.830 -14.059 23.604 1.00 7.56 N

ATOM 5170 CE2 TRP B 301 40.981 -15.394 23.344 1.00 7.81 C

ATOM 5171 CD2 TRP B 301 39.729 -16.013 23.568 1.00 7.80 C

ATOM 5172 CE3 TRP B 301 39.612 -17.396 23.377 1.00 6.96 C

ATOM 5173 CZ3 TRP B 301 40.738 -18.112 22.971 1.00 7.86 C

ATOM 5174 CH2 TRP B 301 41.973 -17.467 22.757 1.00 8.03 C

ATOM 5175 CZ2 TRP B 301 42.114 -16.113 22.939 1.00 8.09 C

ATOM 5176 C TRP B 301 35.205 -14.092 24.882 1.00 7.06 C

ATOM 5177 O TRP B 301 34.496 -15.004 25.310 1.00 6.91 O

ATOM 5178 N ALA B 302 34.739 -13.084 24.146 1.00 6.70 N

ATOM 5179 CA ALA B 302 33.385 -13.091 23.582 1.00 6.56 C

ATOM 5180 CB ALA B 302 33.154 -11.837 22.747 1.00 6.68 C

ATOM 5181 C ALA B 302 33.195 -14.326 22.715 1.00 6.34 C

ATOM 5182 O ALA B 302 34.171 -14.850 22.165 1.00 5.83 O

ATOM 5183 N TYR B 303 31.949 -14.787 22.570 1.00 6.39 N

ATOM 5184 CA TYR B 303 31.682 -15.933 21.699 1.00 6.24 C

ATOM 5185 CB TYR B 303 30.190 -16.280 21.602 1.00 6.41 C

ATOM 5186 CG TYR B 303 29.901 -17.495 20.726 1.00 7.32 C

ATOM 5187 CDl TYR B 303 30.402 -18.761 21.055 1.00 7.44 C

ATOM 5188 CEl TYR B 303 30.137 -19.883 20.251 1.00 7.27 C

ATOM 5189 CZ TYR B 303 29.364 -19.740 19.109 1.00 8.28 C

ATOM 5190 OH TYR B 303 29.093 -20.839 18.311 1.00 8.56 O

ATOM 5191 CE2 TYR B 303 28.852 -18.496 18.766 1.00 7.18 C

ATOM 5192 CD2 TYR B 303 29.122 -17.381 19.572 1.00 7.47 C

ATOM 5193 C TYR B 303 32.269 -15.741 20.306 1.00 6.20 C

ATOM 5194 O TYR B 303 32.848 -16.673 19.751 1.00 6.09 O

ATOM 5195 N TYR B 304 32.137 -14.536 19.747 1.00 6.01 N

ATOM 5196 CA TYR B 304 32.679 -14.281 18.409 1.00 5.93 C

ATOM 5197 CB TYR B 304 32.085 -13.017 17.767 1.00 5.79 C

ATOM 5198 CG TYR B 304 32.337 -11.712 18.494 1.00 5.59 C

ATOM 5199 CDl TYR B 304 31.375 -11.167 19.347 1.00 4.87 C

ATOM 5200 CEl TYR B 304 31.601 -9.947 20.003 1.00 5.79 C

ATOM 5201 CZ TYR B 304 32.800 -9.276 19.799 1.00 5.63 C

ATOM 5202 OH TYR B 304 33.053 -8.076 20.427 1.00 6.27 O

ATOM 5203 CE2 TYR B 304 33.763 -9.799 18.949 1.00 5.39 C

ATOM 5204 CD2 TYR B 304 33.523 -11.006 18.298 1.00 5.44 C

ATOM 5205 C TYR B 304 34.214 -14.300 18.378 1.00 5.86 C

ATOM 5206 O TYR B 304 34.815 -14.668 17.364 1.00 5.86 O

ATOM 5207 N GLU B 305 34.838 -13.912 19.490 1.00 5.76 N

ATOM 5208 CA GLU B 305 36.296 -14.027 19.638 1.00 6.15 C W2025-7029WO / AM102903-PCT

ATOM 5209 CB GLU B 305 36.793 -13.260 20.870 1.00 6.13 C

ATOM 5210 CG GLU B 305 36.626 -11.744 20.747 1.00 6.63 C

ATOM 5211 CD GLU B 305 37.095 -10.973 21.971 1.00 6.69 C

ATOM 5212 OEl GLU B 305 36.911 -11.457 23.114 1.00 7.49 O

ATOM 5213 OE2 GLU B 305 37.633 -9.860 21.782 1.00 7.16 O

ATOM 5214 C GLU B 305 36.735 -15.494 19.698 1.00 6.08 C

ATOM 5215 O GLU B 305 37.797 -15.852 19.170 1.00 6.04 O

ATOM 5216 N ILE B 306 35.916 -16.337 20.327 1.00 5.84 N

ATOM 5217 CA ILE B 306 36.167 -17.782 20.348 1.00 6.10 C

ATOM 5218 CB ILE B 306 35.252 -18.524 21.361 1.00 6.17 C

ATOM 5219 CGl ILE B 306 35.520 -18.012 22.783 1.00 5.88 C

ATOM 5220 CDl ILE B 306 34.499 -18.464 23.812 1.00 6.07 C

ATOM 5221 CG2 ILE B 306 35.468 -20.044 21.298 1.00 5.50 C

ATOM 5222 C ILE B 306 36.059 -18.400 18.947 1.00 6.66 C

ATOM 5223 O ILE B 306 36.844 -19.285 18.598 1.00 6.73 O

ATOM 5224 N CYS B 307 35.101 -17.924 18.145 1.00 6.59 N

ATOM 5225 CA CYS B 307 34.963 -18.387 16.764 1.00 7.10 C

ATOM 5226 CB CYS B 307 33.720 -17.776 16.099 1.00 7.05 C

ATOM 5227 SG CYS B 307 32.165 -18.350 16.860 1.00 8.98 S

ATOM 5228 C CYS B 307 36.246 -18.142 15.947 1.00 7.02 C

ATOM 5229 O CYS B 307 36.641 -18.981 15.136 1.00 7.09 O

ATOM 5230 N THR B 308 36.892 -17.001 16.187 1.00 7.25 N

ATOM 5231 CA THR B 308 38.204 -16.676 15.597 1.00 7.48 C

ATOM 5232 CB THR B 308 38.680 -15.268 16.025 1.00 7.20 C

ATOM 5233 OGl THR B 308 37.714 -14.300 15.614 1.00 8.59 O

ATOM 5234 CG2 THR B 308 40.043 -14.915 15.408 1.00 7.41 C

ATOM 5235 C THR B 308 39.262 -17.698 16.013 1.00 7.60 C

ATOM 5236 O THR B 308 40.015 -18.198 15.169 1.00 7.91 O

ATOM 5237 N PHE B 309 39.303 -17.989 17.315 1.00 7.61 N

ATOM 5238 CA PHE B 309 40.192 -19.000 17.897 1.00 7.83 C

ATOM 5239 CB PHE B 309 39.873 -19.156 19.394 1.00 7.73 C

ATOM 5240 CG PHE B 309 40.859 -20.010 20.170 1.00 7.47 C

ATOM 5241 CDl PHE B 309 42.228 -19.764 20.114 1.00 6.98 C

ATOM 5242 CEl PHE B 309 43.127 -20.542 20.857 1.00 7.76 C

ATOM 5243 CZ PHE B 309 42.650 -21.557 21.680 1.00 7.87 C

ATOM 5244 CE2 PHE B 309 41.283 -21.804 21.754 1.00 7.19 C

ATOM 5245 CD2 PHE B 309 40.396 -21.025 21.008 1.00 6.95 C

ATOM 5246 C PHE B 309 40.046 -20.326 17.143 1.00 8.01 C

ATOM 5247 O PHE B 309 41.041 -20.902 16.687 1.00 7.41 O

ATOM 5248 N LEU B 310 38.798 -20.767 16.976 1.00 8.09 N

ATOM 5249 CA LEU B 310 38.480 -21.963 16.195 1.00 8.53 C

ATOM 5250 CB LEU B 310 36.988 -22.309 16.310 1.00 8.56 C

ATOM 5251 CG LEU B 310 36.450 -22.609 17.719 1.00 8.48 C

ATOM 5252 CDl LEU B 310 34.942 -22.845 17.694 1.00 7.96 C

ATOM 5253 CD2 LEU B 310 37.176 -23.786 18.352 1.00 8.83 C

ATOM 5254 C LEU B 310 38.903 -21.846 14.727 1.00 9.10 C

ATOM 5255 O LEU B 310 39.580 -22.735 14.212 1.00 9.12 O

ATOM 5256 N LYS B 311 38.516 -20.747 14.067 1.00 9.48 N

ATOM 5257 CA LYS B 311 38.895 -20.478 12.667 1.00 10.36 C

ATOM 5258 CB LYS B 311 38.413 -19.092 12.226 1.00 9.97 C

ATOM 5259 CG LYS B 311 36.963 -19.005 11.758 1.00 11.86 C

ATOM 5260 CD LYS B 311 36.607 -17.539 11.448 1.00 12.17 C

ATOM 5261 CE LYS B 311 35.398 -17.409 10.534 1.00 14.78 C

ATOM 5262 NZ LYS B 311 35.153 -15.976 10.147 1.00 15.78 N

ATOM 5263 C LYS B 311 40.407 -20.564 12.427 1.00 9.99 C

ATOM 5264 O LYS B 311 40.855 -21.016 11.370 1.00 9.93 O

ATOM 5265 N ASN B 312 41.183 -20.117 13.412 1.00 10.09 N

ATOM 5266 CA ASN B 312 42.636 -20.059 13.290 1.00 10.17 C

ATOM 5267 CB ASN B 312 43.172 -18.767 13.914 1.00 10.44 C

ATOM 5268 CG ASN B 312 42.948 -17.557 13.022 1.00 10.83 C

ATOM 5269 ODl ASN B 312 43.031 -17.654 11.800 1.00 12.67 O

ATOM 5270 ND2 ASN B 312 42.670 -16.412 13.630 1.00 10.83 N

ATOM 5271 C ASN B 312 43.382 -21.295 13.805 1.00 10.24 C W2025-7029WO / AM102903-PCT

ATOM 5272 O ASN B 312 44.601 -21.252 14.034 1.00 10.16 O

ATOM 5273 N GLY B 313 42.646 -22.391 13.981 1.00 10.22 N

ATOM 5274 CA GLY B 313 43.257 -23.708 14.168 1.00 10.14 C

ATOM 5275 C GLY B 313 43.128 -24.375 15.526 1.00 10.22 C

ATOM 5276 O GLY B 313 43.719 -25.439 15.743 1.00 10.27 O

ATOM 5277 N ALA B 314 42.372 -23.766 16.441 1.00 9.54 N

ATOM 5278 CA ALA B 314 42.149 -24.357 17.758 1.00 9.53 C

ATOM 5279 CB ALA B 314 41.347 -23.416 18.638 1.00 9.21 C

ATOM 5280 C ALA B 314 41.436 -25.705 17.634 1.00 9.51 C

ATOM 5281 O ALA B 314 40.557 -25.875 16.780 1.00 9.20 O

ATOM 5282 N THR B 315 41.833 -26.650 18.487 1.00 9.47 N

ATOM 5283 CA THR B 315 41.216 -27.972 18.563 1.00 9.48 C

ATOM 5284 CB THR B 315 42.202 -29.007 19.154 1.00 9.51 C

ATOM 5285 OGl THR B 315 43.424 -28.983 18.404 1.00 10.34 O

ATOM 5286 CG2 THR B 315 41.612 -30.429 19.123 1.00 9.53 C

ATOM 5287 C THR B 315 39.953 -27.910 19.423 1.00 9.51 C

ATOM 5288 O THR B 315 39.960 -27.323 20.502 1.00 8.91 O

ATOM 5289 N GLN B 316 38.879 -28.531 18.939 1.00 9.94 N

ATOM 5290 CA GLN B 316 37.597 -28.549 19.646 1.00 10.55 C

ATOM 5291 CB GLN B 316 36.432 -28.570 18.655 1.00 10.91 C

ATOM 5292 CG GLN B 316 36.196 -27.253 17.948 1.00 13.28 C

ATOM 5293 CD GLN B 316 34.779 -27.124 17.413 1.00 17.09 C

ATOM 5294 OEl GLN B 316 34.563 -27.109 16.197 1.00 18.34 O

ATOM 5295 NE2 GLN B 316 33.801 -27.024 18.325 1.00 17.43 N

ATOM 5296 C GLN B 316 37.463 -29.730 20.595 1.00 10.28 C

ATOM 5297 O GLN B 316 37.712 -30.874 20.219 1.00 10.47 O

ATOM 5298 N GLY B 317 37.046 -29.441 21.820 1.00 10.19 N

ATOM 5299 CA GLY B 317 36.810 -30.469 22.829 1.00 10.03 C

ATOM 5300 C GLY B 317 35.383 -30.431 23.350 1.00 9.95 C

ATOM 5301 O GLY B 317 34.711 -29.397 23.291 1.00 9.58 O

ATOM 5302 N TRP B 318 34.918 -31.571 23.852 1.00 9.88 N

ATOM 5303 CA TRP B 318 33.602 -31.652 24.480 1.00 10.17 C

ATOM 5304 CB TRP B 318 32.612 -32.436 23.605 1.00 10.15 C

ATOM 5305 CG TRP B 318 31.196 -32.428 24.142 1.00 10.10 C

ATOM 5306 CDl TRP B 318 30.555 -33.455 24.765 1.00 10.32 C

ATOM 5307 NEl TRP B 318 29.279 -33.076 25.124 1.00 10.31 N

ATOM 5308 CE2 TRP B 318 29.078 -31.778 24.738 1.00 10.31 C

ATOM 5309 CD2 TRP B 318 30.265 -31.333 24.114 1.00 10.10 C

ATOM 5310 CE3 TRP B 318 30.319 -30.022 23.623 1.00 9.87 C

ATOM 5311 CZ3 TRP B 318 29.196 -29.208 23.762 1.00 9.95 C

ATOM 5312 CH2 TRP B 318 28.029 -29.679 24.388 1.00 10.21 C

ATOM 5313 CZ2 TRP B 318 27.949 -30.957 24.879 1.00 10.84 C

ATOM 5314 C TRP B 318 33.719 -32.253 25.880 1.00 10.19 C

ATOM 5315 O TRP B 318 34.326 -33.314 26.068 1.00 10.43 O

ATOM 5316 N ASP B 319 33.155 -31.543 26.851 1.00 10.19 N

ATOM 5317 CA ASP B 319 33.108 -31.969 28.242 1.00 10.31 C

ATOM 5318 CB ASP B 319 33.303 -30.742 29.146 1.00 10.17 C

ATOM 5319 CG ASP B 319 33.237 -31.060 30.640 1.00 9.99 C

ATOM 5320 ODl ASP B 319 33.405 -30.108 31.435 1.00 8.26 O

ATOM 5321 OD2 ASP B 319 33.032 -32.232 31.027 1.00 10.06 O

ATOM 5322 C ASP B 319 31.748 -32.641 28.465 1.00 10.58 C

ATOM 5323 O ASP B 319 30.777 -31.993 28.865 1.00 10.46 O

ATOM 5324 N ALA B 320 31.694 -33.945 28.210 1.00 10.96 N

ATOM 5325 CA ALA B 320 30.419 -34.667 28.104 1.00 11.22 C

ATOM 5326 CB ALA B 320 30.629 -36.077 27.513 1.00 11.31 C

ATOM 5327 C ALA B 320 29.554 -34.717 29.376 1.00 11.31 C

ATOM 5328 O ALA B 320 28.359 -34.420 29.306 1.00 11.62 O

ATOM 5329 N PRO B 321 30.134 -35.096 30.535 1.00 11.48 N

ATOM 5330 CA PRO B 321 29.291 -35.089 31.737 1.00 11.54 C

ATOM 5331 CB PRO B 321 30.229 -35.598 32.840 1.00 11.66 C

ATOM 5332 CG PRO B 321 31.597 -35.428 32.308 1.00 11.66 C

ATOM 5333 CD PRO B 321 31.501 -35.567 30.829 1.00 11.41 C

ATOM 5334 C PRO B 321 28.718 -33.715 32.111 1.00 11.66 C W2025-7029WO / AM102903-PCT

ATOM 5335 O PRO B 321 27.666 -33.649 32.748 1.00 11.86 O

ATOM 5336 N GLN B 322 29.391 -32.636 31.712 1.00 11.47 N

ATOM 5337 CA GLN B 322 28.958 -31.282 32.072 1.00 11.28 C

ATOM 5338 CB GLN B 322 30.138 -30.465 32.602 1.00 11.52 C

ATOM 5339 CG GLN B 322 30.814 -31.107 33.801 1.00 11.36 C

ATOM 5340 CD GLN B 322 31.701 -30.161 34.572 1.00 11.77 C

ATOM 5341 OEl GLN B 322 31.417 -29.843 35.728 1.00 12.83 O

ATOM 5342 NE2 GLN B 322 32.789 -29.714 33.950 1.00 11.76 N

ATOM 5343 C GLN B 322 28.241 -30.557 30.925 1.00 11.19 C

ATOM 5344 O GLN B 322 27.712 -29.450 31.106 1.00 11.15 O

ATOM 5345 N GLU B 323 28.231 -31.203 29.758 1.00 10.73 N

ATOM 5346 CA GLU B 323 27.462 -30.776 28.584 1.00 10.72 C

ATOM 5347 CB GLU B 323 25.951 -30.843 28.867 1.00 11.34 C

ATOM 5348 CG GLU B 323 25.452 -32.201 29.382 1.00 12.98 C

ATOM 5349 CD GLU B 323 25.331 -33.270 28.293 1.00 15.92 C

ATOM 5350 OEl GLU B 323 24.827 -34.371 28.609 1.00 17.95 O

ATOM 5351 OE2 GLU B 323 25.736 -33.029 27.132 1.00 16.98 O

ATOM 5352 C GLU B 323 27.862 -29.406 28.008 1.00 9.84 C

ATOM 5353 O GLU B 323 27.011 -28.654 27.525 1.00 9.39 O

ATOM 5354 N VAL B 324 29.160 -29.107 28.049 1.00 9.25 N

ATOM 5355 CA VAL B 324 29.702 -27.825 27.570 1.00 8.64 C

ATOM 5356 CB VAL B 324 29.906 -26.800 28.733 1.00 8.62 C

ATOM 5357 CGl VAL B 324 28.590 -26.099 29.085 1.00 8.43 C

ATOM 5358 CG2 VAL B 324 30.499 -27.467 29.971 1.00 8.55 C

ATOM 5359 C VAL B 324 31.007 -28.020 26.770 1.00 8.41 C

ATOM 5360 O VAL B 324 31.751 -28.962 27.026 1.00 8.53 O

ATOM 5361 N PRO B 325 31.266 -27.152 25.770 1.00 8.11 N

ATOM 5362 CA PRO B 325 32.494 -27.286 24.993 1.00 7.90 C

ATOM 5363 CB PRO B 325 32.145 -26.571 23.691 1.00 8.15 C

ATOM 5364 CG PRO B 325 31.244 -25.470 24.130 1.00 7.85 C

ATOM 5365 CD PRO B 325 30.426 -26.048 25.264 1.00 7.95 C

ATOM 5366 C PRO B 325 33.727 -26.625 25.618 1.00 7.64 C

ATOM 5367 O PRO B 325 33.622 -25.823 26.551 1.00 7.58 O

ATOM 5368 N TYR B 326 34.887 -26.986 25.088 1.00 7.32 N

ATOM 5369 CA TYR B 326 36.133 -26.292 25.370 1.00 6.84 C

ATOM 5370 CB TYR B 326 36.821 -26.838 26.636 1.00 7.10 C

ATOM 5371 CG TYR B 326 37.381 -28.253 26.555 1.00 7.03 C

ATOM 5372 CDl TYR B 326 38.723 -28.472 26.240 1.00 7.15 C

ATOM 5373 CEl TYR B 326 39.251 -29.758 26.178 1.00 6.42 C

ATOM 5374 CZ TYR B 326 38.438 -30.849 26.447 1.00 7.29 C

ATOM 5375 OH TYR B 326 38.969 -32.119 26.389 1.00 6.60 O

ATOM 5376 CE2 TYR B 326 37.099 -30.663 26.770 1.00 6.98 C

ATOM 5377 CD2 TYR B 326 36.582 -29.364 26.835 1.00 7.03 C

ATOM 5378 C TYR B 326 37.026 -26.368 24.133 1.00 6.70 C

ATOM 5379 O TYR B 326 36.755 -27.142 23.213 1.00 6.45 O

ATOM 5380 N ALA B 327 38.062 -25.538 24.093 1.00 6.39 N

ATOM 5381 CA ALA B 327 38.983 -25.518 22.964 1.00 6.40 C

ATOM 5382 CB ALA B 327 38.478 -24.566 21.862 1.00 6.43 C

ATOM 5383 C ALA B 327 40.382 -25.128 23.417 1.00 6.58 C

ATOM 5384 O ALA B 327 40.549 -24.437 24.423 1.00 6.13 O

ATOM 5385 N TYR B 328 41.381 -25.579 22.663 1.00 6.85 N

ATOM 5386 CA TYR B 328 42.779 -25.396 23.030 1.00 7.15 C

ATOM 5387 CB TYR B 328 43.245 -26.500 23.993 1.00 7.48 C

ATOM 5388 CG TYR B 328 42.916 -27.907 23.530 1.00 7.78 C

ATOM 5389 CDl TYR B 328 41.681 -28.490 23.827 1.00 7.91 C

ATOM 5390 CEl TYR B 328 41.367 -29.778 23.397 1.00 8.09 C

ATOM 5391 CZ TYR B 328 42.302 -30.501 22.667 1.00 8.69 C

ATOM 5392 OH TYR B 328 42.000 -31.777 22.247 1.00 7.92 O

ATOM 5393 CE2 TYR B 328 43.538 -29.943 22.354 1.00 8.68 C

ATOM 5394 CD2 TYR B 328 43.836 -28.651 22.782 1.00 8.17 C

ATOM 5395 C TYR B 328 43.679 -25.360 21.805 1.00 7.26 C

ATOM 5396 O TYR B 328 43.396 -25.994 20.786 1.00 7.26 O

ATOM 5397 N GLN B 329 44.765 -24.607 21.928 1.00 7.63 N W2025-7029WO / AM102903-PCT

ATOM 5398 CA GLN B 329 45.789 -24.494 20.905 1.00 7.84 C

ATOM 5399 CB GLN B 329 45.309 -23.570 19.785 1.00 8.06 C

ATOM 5400 CG GLN B 329 46.312 -23.348 18.662 1.00 9.19 C

ATOM 5401 CD GLN B 329 45.795 -22.392 17.610 1.00 8.56 C

ATOM 5402 OEl GLN B 329 45.389 -21.265 17.915 1.00 9.15 O

ATOM 5403 NE2 GLN B 329 45.817 -22.831 16.364 1.00 8.58 N

ATOM 5404 C GLN B 329 47.036 -23.923 21.583 1.00 7.70 C

ATOM 5405 O GLN B 329 46.957 -22.914 22.289 1.00 7.74 O

ATOM 5406 N GLY B 330 48.178 -24.574 21.377 1.00 7.54 N

ATOM 5407 CA GLY B 330 49.427 -24.170 22.030 1.00 7.18 C

ATOM 5408 C GLY B 330 49.238 -24.166 23.535 1.00 6.97 C

ATOM 5409 O GLY B 330 48.707 -25.128 24.104 1.00 6.70 O

ATOM 5410 N ASN B 331 49.628 -23.068 24.176 1.00 6.66 N

ATOM 5411 CA ASN B 331 49.446 -22.927 25.619 1.00 6.80 C

ATOM 5412 CB ASN B 331 50.700 -22.321 26.271 1.00 6.83 C

ATOM 5413 CG ASN B 331 50.984 -20.901 25.801 1.00 6.99 C

ATOM 5414 ODl ASN B 331 50.476 -20.458 24.773 1.00 8.17 O

ATOM 5415 ND2 ASN B 331 51.810 -20.183 26.555 1.00 7.84 N

ATOM 5416 C ASN B 331 48.187 -22.132 26.014 1.00 6.76 C

ATOM 5417 O ASN B 331 48.139 -21.558 27.098 1.00 6.58 O

ATOM 5418 N VAL B 332 47.182 -22.101 25.138 1.00 6.70 N

ATOM 5419 CA VAL B 332 45.939 -21.349 25.410 1.00 6.51 C

ATOM 5420 CB VAL B 332 45.717 -20.190 24.386 1.00 6.83 C

ATOM 5421 CGl VAL B 332 44.472 -19.358 24.733 1.00 5.84 C

ATOM 5422 CG2 VAL B 332 46.942 -19.274 24.311 1.00 6.49 C

ATOM 5423 C VAL B 332 44.721 -22.284 25.451 1.00 6.54 C

ATOM 5424 O VAL B 332 44.572 -23.159 24.595 1.00 6.86 O

ATOM 5425 N TRP B 333 43.860 -22.085 26.448 1.00 6.36 N

ATOM 5426 CA TRP B 333 42.687 -22.935 26.683 1.00 6.06 C

ATOM 5427 CB TRP B 333 42.975 -23.853 27.874 1.00 6.03 C

ATOM 5428 CG TRP B 333 42.058 -25.048 28.065 1.00 6.41 C

ATOM 5429 CDl TRP B 333 42.289 -26.332 27.653 1.00 6.98 C

ATOM 5430 NEl TRP B 333 41.247 -27.150 28.037 1.00 7.25 N

ATOM 5431 CE2 TRP B 333 40.321 -26.406 28.721 1.00 6.95 C

ATOM 5432 CD2 TRP B 333 40.798 -25.074 28.766 1.00 6.96 C

ATOM 5433 CE3 TRP B 333 40.026 -24.099 29.422 1.00 6.61 C

ATOM 5434 CZ3 TRP B 333 38.813 -24.482 29.998 1.00 6.74 C

ATOM 5435 CH2 TRP B 333 38.363 -25.819 29.931 1.00 6.88 C

ATOM 5436 CZ2 TRP B 333 39.103 -26.791 29.302 1.00 6.02 C

ATOM 5437 C TRP B 333 41.469 -22.051 26.980 1.00 5.67 C

ATOM 5438 O TRP B 333 41.592 -21.041 27.663 1.00 5.21 O

ATOM 5439 N VAL B 334 40.303 -22.430 26.463 1.00 5.35 N

ATOM 5440 CA VAL B 334 39.065 -21.688 26.735 1.00 5.60 C

ATOM 5441 CB VAL B 334 38.720 -20.662 25.586 1.00 5.67 C

ATOM 5442 CGl VAL B 334 38.610 -21.349 24.227 1.00 5.47 C

ATOM 5443 CG2 VAL B 334 37.440 -19.864 25.896 1.00 6.08 C

ATOM 5444 C VAL B 334 37.899 -22.633 27.042 1.00 5.47 C

ATOM 5445 O VAL B 334 37.698 -23.631 26.351 1.00 5.48 O

ATOM 5446 N GLY B 335 37.159 -22.321 28.103 1.00 5.68 N

ATOM 5447 CA GLY B 335 35.955 -23.055 28.472 1.00 5.82 C

ATOM 5448 C GLY B 335 34.784 -22.154 28.177 1.00 6.00 C

ATOM 5449 O GLY B 335 34.784 -20.999 28.585 1.00 6.06 O

ATOM 5450 N TYR B 336 33.793 -22.662 27.450 1.00 6.16 N

ATOM 5451 CA TYR B 336 32.737 -21.791 26.940 1.00 6.47 C

ATOM 5452 CB TYR B 336 33.213 -21.061 25.668 1.00 6.04 C

ATOM 5453 CG TYR B 336 33.451 -21.936 24.451 1.00 6.04 C

ATOM 5454 CDl TYR B 336 34.563 -22.785 24.373 1.00 6.65 C

ATOM 5455 CEl TYR B 336 34.785 -23.582 23.247 1.00 5.58 C

ATOM 5456 CZ TYR B 336 33.889 -23.526 22.186 1.00 5.76 C

ATOM 5457 OH TYR B 336 34.094 -24.300 21.071 1.00 5.44 O

ATOM 5458 CE2 TYR B 336 32.787 -22.686 22.240 1.00 5.69 C

ATOM 5459 CD2 TYR B 336 32.578 -21.896 23.366 1.00 4.74 C

ATOM 5460 C TYR B 336 31.398 -22.491 26.718 1.00 6.71 C W2025-7029WO / AM102903-PCT

ATOM 5461 O TYR B 336 31.169 -23.584 27.235 1.00 6.77 O

ATOM 5462 N ASP B 337 30.508 -21.811 25.996 1.00 7.02 N

ATOM 5463 CA ASP B 337 29.219 -22.347 25.578 1.00 7.52 C

ATOM 5464 CB ASP B 337 28.065 -21.661 26.320 1.00 7.39 C

ATOM 5465 CG ASP B 337 27.772 -22.289 27.667 1.00 7.40 C

ATOM 5466 ODl ASP B 337 28.383 -21.871 28.673 1.00 7.84 O

ATOM 5467 OD2 ASP B 337 26.917 -23.196 27.720 1.00 7.14 O

ATOM 5468 C ASP B 337 29.034 -22.127 24.082 1.00 7.96 C

ATOM 5469 O ASP B 337 29.427 -21.084 23.542 1.00 8.19 O

ATOM 5470 N ASN B 338 28.439 -23.115 23.417 1.00 8.26 N

ATOM 5471 CA ASN B 338 28.075 -22.995 22.004 1.00 8.53 C

ATOM 5472 CB ASN B 338 28.945 -23.904 21.111 1.00 8.45 C

ATOM 5473 CG ASN B 338 28.876 -25.385 21.501 1.00 9.06 C

ATOM 5474 ODl ASN B 338 28.007 -25.815 22.270 1.00 9.03 O

ATOM 5475 ND2 ASN B 338 29.807 -26.172 20.964 1.00 8.80 N

ATOM 5476 C ASN B 338 26.585 -23.265 21.804 1.00 8.67 C

ATOM 5477 O ASN B 338 25.829 -23.309 22.776 1.00 8.84 O

ATOM 5478 N VAL B 339 26.167 -23.425 20.549 1.00 8.92 N

ATOM 5479 CA VAL B 339 24.762 -23.683 20.222 1.00 9.14 C

ATOM 5480 CB VAL B 339 24.521 -23.716 18.681 1.00 9.11 C

ATOM 5481 CGl VAL B 339 23.055 -24.001 18.367 1.00 8.69 C

ATOM 5482 CG2 VAL B 339 24.945 -22.401 18.046 1.00 8.67 C

ATOM 5483 C VAL B 339 24.277 -24.982 20.878 1.00 9.41 C

ATOM 5484 O VAL B 339 23.175 -25.032 21.450 1.00 9.23 O

ATOM 5485 N LYS B 340 25.112 -26.019 20.810 1.00 9.51 N

ATOM 5486 CA LYS B 340 24.781 -27.315 21.397 1.00 10.16 C

ATOM 5487 CB LYS B 340 25.858 -28.368 21.083 1.00 10.10 C

ATOM 5488 CG LYS B 340 25.496 -29.797 21.505 1.00 10.76 C

ATOM 5489 CD LYS B 340 26.601 -30.782 21.130 1.00 11.56 C

ATOM 5490 CE LYS B 340 26.344 -32.162 21.733 1.00 13.70 C

ATOM 5491 NZ LYS B 340 27.531 -33.056 21.570 1.00 16.23 N

ATOM 5492 C LYS B 340 24.519 -27.216 22.901 1.00 9.78 C

ATOM 5493 O LYS B 340 23.490 -27.701 23.376 1.00 9.95 O

ATOM 5494 N SER B 341 25.425 -26.570 23.639 1.00 9.44 N

ATOM 5495 CA SER B 341 25.276 -26.449 25.097 1.00 9.27 C

ATOM 5496 CB SER B 341 26.570 -25.966 25.769 1.00 9.20 C

ATOM 5497 OG SER B 341 26.975 -24.695 25.296 1.00 8.98 O

ATOM 5498 C SER B 341 24.085 -25.577 25.505 1.00 9.54 C

ATOM 5499 O SER B 341 23.356 -25.920 26.435 1.00 9.28 O

ATOM 5500 N PHE B 342 23.902 -24.458 24.803 1.00 9.74 N

ATOM 5501 CA PHE B 342 22.722 -23.610 24.972 1.00 10.06 C

ATOM 5502 CB PHE B 342 22.795 -22.387 24.043 1.00 9.88 C

ATOM 5503 CG PHE B 342 23.357 -21.137 24.699 1.00 9.91 C

ATOM 5504 CDl PHE B 342 24.463 -21.198 25.549 1.00 9.66 C

ATOM 5505 CEl PHE B 342 24.975 -20.034 26.146 1.00 9.46 C

ATOM 5506 CZ PHE B 342 24.386 -18.798 25.878 1.00 9.71 C

ATOM 5507 CE2 PHE B 342 23.289 -18.725 25.023 1.00 9.23 C

ATOM 5508 CD2 PHE B 342 22.785 -19.889 24.438 1.00 9.19 C

ATOM 5509 C PHE B 342 21.421 -24.405 24.753 1.00 10.32 C

ATOM 5510 O PHE B 342 20.512 -24.348 25.582 1.00 10.17 O

ATOM 5511 N ASP B 343 21.352 -25.161 23.655 1.00 11.04 N

ATOM 5512 CA ASP B 343 20.183 -25.996 23.359 1.00 11.71 C

ATOM 5513 CB ASP B 343 20.344 -26.721 22.015 1.00 12.25 C

ATOM 5514 CG ASP B 343 19.006 -27.079 21.380 1.00 15.17 C

ATOM 5515 ODl ASP B 343 18.145 -26.178 21.245 1.00 17.06 O

ATOM 5516 OD2 ASP B 343 18.807 -28.263 21.008 1.00 18.62 O

ATOM 5517 C ASP B 343 19.880 -26.997 24.480 1.00 11.57 C

ATOM 5518 O ASP B 343 18.738 -27.095 24.935 1.00 11.42 O

ATOM 5519 N ILE B 344 20.913 -27.712 24.930 1.00 11.55 N

ATOM 5520 CA ILE B 344 20.807 -28.680 26.031 1.00 11.71 C

ATOM 5521 CB ILE B 344 22.170 -29.401 26.291 1.00 11.73 C

ATOM 5522 CGl ILE B 344 22.522 -30.340 25.130 1.00 11.79 C

ATOM 5523 CDl ILE B 344 23.992 -30.788 25.112 1.00 11.16 C W2025-7029WO / AM102903-PCT

ATOM 5524 CG2 ILE B 344 22.147 -30.186 27.606 1.00 11.91 C

ATOM 5525 C ILE B 344 20.299 -28.028 27.323 1.00 11.86 C

ATOM 5526 O ILE B 344 19.403 -28.561 27.986 1.00 11.82 O

ATOM 5527 N LYS B 345 20.870 -26.873 27.668 1.00 11.86 N

ATOM 5528 CA LYS B 345 20.486 -26.143 28.878 1.00 11.88 C

ATOM 5529 CB LYS B 345 21.469 -25.016 29.150 1.00 11.83 C

ATOM 5530 CG LYS B 345 22.806 -25.451 29.706 1.00 11.59 C

ATOM 5531 CD LYS B 345 23.742 -24.263 29.751 1.00 11.28 C

ATOM 5532 CE LYS B 345 25.143 -24.674 30.125 1.00 10.60 C

ATOM 5533 NZ LYS B 345 26.023 -23.476 30.186 1.00 9.40 N

ATOM 5534 C LYS B 345 19.067 -25.578 28.798 1.00 11.94 C

ATOM 5535 O LYS B 345 18.360 -25.513 29.808 1.00 11.68 O

ATOM 5536 N ALA B 346 18.667 -25.168 27.597 1.00 12.32 N

ATOM 5537 CA ALA B 346 17.317 -24.652 27.347 1.00 12.64 C

ATOM 5538 CB ALA B 346 17.213 -24.103 25.938 1.00 12.36 C

ATOM 5539 C ALA B 346 16.275 -25.741 27.571 1.00 13.02 C

ATOM 5540 O ALA B 346 15.230 -25.497 28.185 1.00 13.02 O

ATOM 5541 N GLN B 347 16.576 -26.945 27.084 1.00 13.60 N

ATOM 5542 CA GLN B 347 15.694 -28.093 27.271 1.00 14.03 C

ATOM 5543 CB GLN B 347 16.143 -29.283 26.416 1.00 14.15 C

ATOM 5544 CG GLN B 347 15.938 -29.097 24.912 1.00 15.88 C

ATOM 5545 CD GLN B 347 14.533 -28.609 24.536 1.00 17.55 C

ATOM 5546 OEl GLN B 347 14.384 -27.682 23.734 1.00 18.22 O

ATOM 5547 NE2 GLN B 347 13.503 -29.233 25.112 1.00 18.20 N

ATOM 5548 C GLN B 347 15.586 -28.483 28.742 1.00 13.90 C

ATOM 5549 O GLN B 347 14.491 -28.757 29.233 1.00 14.22 O

ATOM 5550 N TRP B 348 16.723 -28.484 29.435 1.00 13.75 N

ATOM 5551 CA TRP B 348 16.786 -28.736 30.877 1.00 13.84 C

ATOM 5552 CB TRP B 348 18.246 -28.675 31.345 1.00 13.58 C

ATOM 5553 CG TRP B 348 18.440 -28.875 32.823 1.00 13.46 C

ATOM 5554 CDl TRP B 348 18.554 -30.065 33.480 1.00 13.59 C

ATOM 5555 NEl TRP B 348 18.726 -29.852 34.828 1.00 13.66 N

ATOM 5556 CE2 TRP B 348 18.729 -28.503 35.067 1.00 13.89 C

ATOM 5557 CD2 TRP B 348 18.551 -27.853 33.824 1.00 14.04 C

ATOM 5558 CE3 TRP B 348 18.516 -26.451 33.792 1.00 13.06 C

ATOM 5559 CZ3 TRP B 348 18.663 -25.754 34.989 1.00 13.50 C

ATOM 5560 CH2 TRP B 348 18.839 -26.430 36.207 1.00 13.43 C

ATOM 5561 CZ2 TRP B 348 18.874 -27.799 36.268 1.00 14.10 C

ATOM 5562 C TRP B 348 15.940 -27.729 31.665 1.00 13.92 C

ATOM 5563 O TRP B 348 15.153 -28.105 32.541 1.00 13.89 O

ATOM 5564 N LEU B 349 16.131 -26.451 31.342 1.00 14.05 N

ATOM 5565 CA LEU B 349 15.397 -25.327 31.923 1.00 14.09 C

ATOM 5566 CB LEU B 349 15.817 -24.060 31.170 1.00 14.05 C

ATOM 5567 CG LEU B 349 15.292 -22.636 31.337 1.00 14.02 C

ATOM 5568 CDl LEU B 349 16.166 -21.759 30.441 1.00 12.25 C

ATOM 5569 CD2 LEU B 349 13.809 -22.463 30.983 1.00 11.43 C

ATOM 5570 C LEU B 349 13.880 -25.514 31.825 1.00 14.19 C

ATOM 5571 O LEU B 349 13.145 -25.295 32.794 1.00 13.95 O

ATOM 5572 N LYS B 350 13.424 -25.898 30.638 1.00 14.41 N

ATOM 5573 CA LYS B 350 12.008 -26.118 30.380 1.00 15.10 C

ATOM 5574 CB LYS B 350 11.760 -26.287 28.882 1.00 14.91 C

ATOM 5575 CG LYS B 350 11.919 -24.997 28.086 1.00 14.88 C

ATOM 5576 CD LYS B 350 11.442 -25.153 26.656 1.00 15.24 C

ATOM 5577 CE LYS B 350 12.399 -25.996 25.846 1.00 15.28 C

ATOM 5578 NZ LYS B 350 11.872 -26.283 24.479 1.00 15.09 N

ATOM 5579 C LYS B 350 11.479 -27.328 31.146 1.00 15.53 C

ATOM 5580 O LYS B 350 10.399 -27.276 31.738 1.00 15.55 O

ATOM 5581 N HIS B 351 12.257 -28.407 31.139 1.00 15.93 N

ATOM 5582 CA HIS B 351 11.886 -29.635 31.832 1.00 16.32 C

ATOM 5583 CB HIS B 351 12.823 -30.775 31.430 1.00 16.52 C

ATOM 5584 CG HIS B 351 12.714 -31.164 29.988 1.00 17.12 C

ATOM 5585 NDl HIS B 351 13.780 -31.662 29.269 1.00 18.07 N

ATOM 5586 CEl HIS B 351 13.395 -31.903 28.027 1.00 17.96 C W2025-7029WO / AM102903-PCT

ATOM 5587 NE2 HIS B 351 12.122 -31.571 27.914 1.00 17.96 N

ATOM 5588 CD2 HIS B 351 11.672 -31.104 29.124 1.00 17.40 C

ATOM 5589 C HIS B 351 11.845 -29.485 33.352 1.00 16.33 C

ATOM 5590 O HIS B 351 11.140 -30.235 34.027 1.00 16.64 O

ATOM 5591 N ASN B 352 12.600 -28.521 33.881 1.00 16.12 N

ATOM 5592 CA ASN B 352 12.575 -28.206 35.311 1.00 15.95 C

ATOM 5593 CB ASN B 352 13.973 -27.837 35.814 1.00 15.96 C

ATOM 5594 CG ASN B 352 14.829 -29.046 36.107 1.00 16.41 C

ATOM 5595 ODl ASN B 352 15.040 -29.400 37.270 1.00 17.67 O

ATOM 5596 ND2 ASN B 352 15.333 -29.687 35.060 1.00 15.57 N

ATOM 5597 C ASN B 352 11.600 -27.078 35.643 1.00 15.85 C

ATOM 5598 O ASN B 352 11.534 -26.619 36.793 1.00 15.78 O

ATOM 5599 N LYS B 353 10.871 -26.628 34.622 1.00 15.53 N

ATOM 5600 CA LYS B 353 9.816 -25.607 34.752 1.00 15.57 C

ATOM 5601 CB LYS B 353 8.582 -26.185 35.468 1.00 15.94 C

ATOM 5602 CG LYS B 353 7.810 -27.186 34.617 1.00 17.40 C

ATOM 5603 CD LYS B 353 6.745 -27.906 35.428 1.00 20.60 C

ATOM 5604 CE LYS B 353 5.888 -28.804 34.542 1.00 22.15 C

ATOM 5605 NZ LYS B 353 4.714 -29.378 35.287 1.00 24.10 N

ATOM 5606 C LYS B 353 10.268 -24.278 35.377 1.00 14.90 C

ATOM 5607 O LYS B 353 9.521 -23.634 36.123 1.00 15.03 O

ATOM 5608 N PHE B 354 11.491 -23.863 35.058 1.00 14.04 N

ATOM 5609 CA PHE B 354 11.956 -22.531 35.442 1.00 13.10 C

ATOM 5610 CB PHE B 354 13.487 -22.453 35.423 1.00 13.20 C

ATOM 5611 CG PHE B 354 14.145 -23.295 36.479 1.00 13.40 C

ATOM 5612 CDl PHE B 354 15.070 -24.270 36.129 1.00 14.09 C

ATOM 5613 CEl PHE B 354 15.680 -25.058 37.110 1.00 13.81 C

ATOM 5614 CZ PHE B 354 15.355 -24.877 38.447 1.00 13.50 C

ATOM 5615 CE2 PHE B 354 14.426 -23.912 38.805 1.00 13.80 C

ATOM 5616 CD2 PHE B 354 13.827 -23.127 37.823 1.00 13.50 C

ATOM 5617 C PHE B 354 11.325 -21.464 34.542 1.00 12.30 C

ATOM 5618 O PHE B 354 10.809 -21.777 33.465 1.00 11.96 O

ATOM 5619 N GLY B 355 11.366 -20.213 34.996 1.00 11.55 N

ATOM 5620 CA GLY B 355 10.694 -19.104 34.318 1.00 10.53 C

ATOM 5621 C GLY B 355 11.258 -18.693 32.969 1.00 10.01 C

ATOM 5622 O GLY B 355 10.570 -18.047 32.172 1.00 9.72 O

ATOM 5623 N GLY B 356 12.506 -19.068 32.704 1.00 9.24 N

ATOM 5624 CA GLY B 356 13.143 -18.740 31.438 1.00 8.63 C

ATOM 5625 C GLY B 356 14.647 -18.615 31.555 1.00 8.45 C

ATOM 5626 O GLY B 356 15.257 -19.192 32.460 1.00 8.32 O

ATOM 5627 N ALA B 357 15.233 -17.846 30.638 1.00 8.08 N

ATOM 5628 CA ALA B 357 16.679 -17.673 30.558 1.00 7.94 C

ATOM 5629 CB ALA B 357 17.218 -18.374 29.311 1.00 7.73 C

ATOM 5630 C ALA B 357 17.057 -16.193 30.526 1.00 7.76 C

ATOM 5631 O ALA B 357 16.320 -15.372 29.976 1.00 7.60 O

ATOM 5632 N MET B 358 18.197 -15.859 31.128 1.00 7.44 N

ATOM 5633 CA MET B 358 18.802 -14.541 30.931 1.00 7.14 C

ATOM 5634 CB MET B 358 18.758 -13.673 32.201 1.00 6.93 C

ATOM 5635 CG MET B 358 19.606 -14.142 33.369 1.00 7.28 C

ATOM 5636 SD MET B 358 21.361 -13.730 33.216 1.00 6.90 S

ATOM 5637 CE MET B 358 21.826 -13.829 34.946 1.00 6.50 C

ATOM 5638 C MET B 358 20.209 -14.668 30.333 1.00 7.10 C

ATOM 5639 O MET B 358 20.877 -15.695 30.502 1.00 6.81 O

ATOM 5640 N VAL B 359 20.635 -13.629 29.618 1.00 7.02 N

ATOM 5641 CA VAL B 359 21.854 -13.688 28.819 1.00 6.94 C

ATOM 5642 CB VAL B 359 21.543 -13.607 27.294 1.00 6.87 C

ATOM 5643 CGl VAL B 359 22.824 -13.706 26.469 1.00 6.98 C

ATOM 5644 CG2 VAL B 359 20.576 -14.708 26.873 1.00 6.87 C

ATOM 5645 C VAL B 359 22.839 -12.589 29.215 1.00 6.92 C

ATOM 5646 O VAL B 359 22.506 -11.397 29.187 1.00 7.12 O

ATOM 5647 N TRP B 360 24.042 -13.001 29.606 1.00 6.89 N

ATOM 5648 CA TRP B 360 25.161 -12.079 29.755 1.00 6.73 C

ATOM 5649 CB TRP B 360 25.771 -12.141 31.169 1.00 7.06 C W2025-7029WO / AM102903-PCT

ATOM 5650 CG TRP B 360 26.730 -10.995 31.417 1.00 7.90 C

ATOM 5651 CDl TRP B 360 28.072 -10.968 31.134 1.00 7.66 C

ATOM 5652 NEl TRP B 360 28.604 -9.745 31.467 1.00 7.66 N

ATOM 5653 CE2 TRP B 360 27.608 -8.950 31.972 1.00 8.06 C

ATOM 5654 CD2 TRP B 360 26.409 -9.702 31.949 1.00 7.47 C

ATOM 5655 CE3 TRP B 360 25.228 -9.109 32.423 1.00 7.87 C

ATOM 5656 CZ3 TRP B 360 25.278 -7.799 32.890 1.00 7.91 C

ATOM 5657 CH2 TRP B 360 26.486 -7.076 32.894 1.00 8.27 C

ATOM 5658 CZ2 TRP B 360 27.660 -7.634 32.442 1.00 7.44 C

ATOM 5659 C TRP B 360 26.215 -12.411 28.686 1.00 6.59 C

ATOM 5660 O TRP B 360 26.923 -13.412 28.816 1.00 6.24 O

ATOM 5661 N ALA B 361 26.329 -11.605 27.623 1.00 6.16 N

ATOM 5662 CA ALA B 361 25.507 -10.421 27.359 1.00 6.10 C

ATOM 5663 CB ALA B 361 26.256 -9.148 27.762 1.00 6.05 C

ATOM 5664 C ALA B 361 25.188 -10.393 25.866 1.00 6.14 C

ATOM 5665 O ALA B 361 25.843 -11.086 25.090 1.00 5.84 O

ATOM 5666 N ILE B 362 24.187 -9.600 25.470 1.00 6.11 N

ATOM 5667 CA ILE B 362 23.756 -9.528 24.066 1.00 6.33 C

ATOM 5668 CB ILE B 362 22.435 -8.688 23.892 1.00 6.15 C

ATOM 5669 CGl ILE B 362 21.770 -8.972 22.533 1.00 6.61 C

ATOM 5670 CDl ILE B 362 20.299 -8.552 22.430 1.00 6.33 C

ATOM 5671 CG2 ILE B 362 22.687 -7.182 24.098 1.00 6.06 C

ATOM 5672 C ILE B 362 24.893 -9.062 23.119 1.00 6.52 C

ATOM 5673 O ILE B 362 24.970 -9.492 21.966 1.00 7.13 O

ATOM 5674 N ASP B 363 25.780 -8.208 23.630 1.00 6.44 N

ATOM 5675 CA ASP B 363 26.896 -7.657 22.856 1.00 6.38 C

ATOM 5676 CB ASP B 363 27.351 -6.330 23.471 1.00 6.36 C

ATOM 5677 CG ASP B 363 27.565 -6.419 24.967 1.00 6.65 C

ATOM 5678 ODl ASP B 363 28.530 -7.090 25.402 1.00 6.08 O

ATOM 5679 OD2 ASP B 363 26.768 -5.806 25.710 1.00 6.93 O

ATOM 5680 C ASP B 363 28.092 -8.612 22.687 1.00 6.45 C

ATOM 5681 O ASP B 363 29.045 -8.301 21.964 1.00 6.63 O

ATOM 5682 N LEU B 364 28.032 -9.767 23.349 1.00 6.21 N

ATOM 5683 CA LEU B 364 29.106 -10.759 23.288 1.00 6.18 C

ATOM 5684 CB LEU B 364 29.484 -11.224 24.703 1.00 5.68 C

ATOM 5685 CG LEU B 364 30.012 -10.143 25.661 1.00 5.43 C

ATOM 5686 CDl LEU B 364 30.094 -10.684 27.084 1.00 5.41 C

ATOM 5687 CD2 LEU B 364 31.361 -9.590 25.208 1.00 4.13 C

ATOM 5688 C LEU B 364 28.792 -11.949 22.367 1.00 6.34 C

ATOM 5689 O LEU B 364 29.676 -12.745 22.061 1.00 6.76 O

ATOM 5690 N ASP B 365 27.535 -12.058 21.933 1.00 6.36 N

ATOM 5691 CA ASP B 365 27.126 -13.013 20.897 1.00 6.40 C

ATOM 5692 CB ASP B 365 25.595 -13.070 20.857 1.00 6.34 C

ATOM 5693 CG ASP B 365 25.051 -14.354 20.239 1.00 6.06 C

ATOM 5694 ODl ASP B 365 25.806 -15.148 19.634 1.00 5.79 O

ATOM 5695 OD2 ASP B 365 23.836 -14.562 20.365 1.00 5.03 O

ATOM 5696 C ASP B 365 27.675 -12.524 19.547 1.00 6.67 C

ATOM 5697 O ASP B 365 28.062 -11.367 19.426 1.00 6.24 O

ATOM 5698 N ASP B 366 27.709 -13.396 18.538 1.00 7.18 N

ATOM 5699 CA ASP B 366 28.125 -12.984 17.189 1.00 7.47 C

ATOM 5700 CB ASP B 366 28.553 -14.194 16.340 1.00 7.71 C

ATOM 5701 CG ASP B 366 29.200 -13.793 15.007 1.00 7.82 C

ATOM 5702 ODl ASP B 366 29.593 -12.619 14.849 1.00 7.65 O

ATOM 5703 OD2 ASP B 366 29.313 -14.660 14.111 1.00 7.36 O

ATOM 5704 C ASP B 366 26.993 -12.190 16.526 1.00 7.72 C

ATOM 5705 O ASP B 366 26.230 -12.722 15.711 1.00 7.73 O

ATOM 5706 N PHE B 367 26.895 -10.912 16.890 1.00 8.00 N

ATOM 5707 CA PHE B 367 25.790 -10.062 16.449 1.00 8.50 C

ATOM 5708 CB PHE B 367 25.607 -8.838 17.363 1.00 8.17 C

ATOM 5709 CG PHE B 367 26.764 -7.870 17.360 1.00 8.68 C

ATOM 5710 CDl PHE B 367 27.867 -8.074 18.190 1.00 7.50 C

ATOM 5711 CEl PHE B 367 28.928 -7.164 18.208 1.00 9.01 C

ATOM 5712 CZ PHE B 367 28.882 -6.028 17.400 1.00 8.46 C W2025-7029WO / AM102903-PCT

ATOM 5713 CE2 PHE B 367 27.776 -5.807 16.578 1.00 9.22 C

ATOM 5714 CD2 PHE B 367 26.723 -6.722 16.566 1.00 8.38 C

ATOM 5715 C PHE B 367 25.862 -9.664 14.975 1.00 8.94 C

ATOM 5716 O PHE B 367 24.827 -9.553 14.324 1.00 9.30 O

ATOM 5717 N THR B 368 27.075 -9.468 14.456 1.00 9.29 N

ATOM 5718 CA THR B 368 27.276 -9.159 13.037 1.00 9.57 C

ATOM 5719 CB THR B 368 28.708 -8.622 12.733 1.00 9.73 C

ATOM 5720 OGl THR B 368 29.672 -9.653 12.963 1.00 9.99 O

ATOM 5721 CG2 THR B 368 29.059 -7.406 13.597 1.00 9.84 C

ATOM 5722 C THR B 368 27.045 -10.399 12.173 1.00 9.86 C

ATOM 5723 O THR B 368 26.672 -10.288 11.007 1.00 9.77 O

ATOM 5724 N GLY B 369 27.280 -11.574 12.757 1.00 10.10 N

ATOM 5725 CA GLY B 369 27.238 -12.839 12.034 1.00 10.42 C

ATOM 5726 C GLY B 369 28.470 -13.106 11.183 1.00 10.66 C

ATOM 5727 O GLY B 369 28.493 -14.069 10.417 1.00 11.21 O

ATOM 5728 N THR B 370 29.497 -12.266 11.314 1.00 11.10 N

ATOM 5729 CA THR B 370 30.696 -12.371 10.461 1.00 11.29 C

ATOM 5730 CB THR B 370 31.296 -10.976 10.116 1.00 11.14 C

ATOM 5731 OGl THR B 370 31.694 -10.301 11.316 1.00 11.90 O

ATOM 5732 CG2 THR B 370 30.285 -10.114 9.365 1.00 11.34 C

ATOM 5733 C THR B 370 31.798 -13.279 11.022 1.00 11.40 C

ATOM 5734 O THR B 370 32.809 -13.536 10.350 1.00 11.55 O

ATOM 5735 N PHE B 371 31.600 -13.776 12.242 1.00 11.27 N

ATOM 5736 CA PHE B 371 32.647 -14.524 12.938 1.00 11.21 C

ATOM 5737 CB PHE B 371 32.789 -14.023 14.381 1.00 10.99 C

ATOM 5738 CG PHE B 371 33.506 -12.700 14.514 1.00 10.18 C

ATOM 5739 CDl PHE B 371 32.814 -11.495 14.377 1.00 9.80 C

ATOM 5740 CEl PHE B 371 33.471 -10.270 14.514 1.00 9.64 C

ATOM 5741 CZ PHE B 371 34.839 -10.243 14.804 1.00 10.30 C

ATOM 5742 CE2 PHE B 371 35.536 -11.438 14.954 1.00 10.32 C

ATOM 5743 CD2 PHE B 371 34.864 -12.659 14.810 1.00 10.18 C

ATOM 5744 C PHE B 371 32.457 -16.047 12.940 1.00 11.31 C

ATOM 5745 O PHE B 371 33.428 -16.789 12.804 1.00 11.23 O

ATOM 5746 N CYS B 372 31.215 -16.504 13.095 1.00 11.54 N

ATOM 5747 CA CYS B 372 30.940 -17.909 13.416 1.00 11.75 C

ATOM 5748 CB CYS B 372 30.068 -18.007 14.684 1.00 11.46 C

ATOM 5749 SG CYS B 372 30.730 -17.116 16.116 1.00 10.52

ATOM 5750 C CYS B 372 30.301 -18.721 12.288 1.00 12.17 C

ATOM 5751 O CYS B 372 30.166 -19.943 12.407 1.00 12.19 O

ATOM 5752 N ASN B 373 29.917 -18.044 11.206 1.00 12.79 N

ATOM 5753 CA ASN B 373 29.184 -18.659 10.082 1.00 13.24 C

ATOM 5754 CB ASN B 373 30.080 -19.633 9.285 1.00 13.66 C

ATOM 5755 CG ASN B 373 29.448 -20.078 7.962 1.00 15.27 C

ATOM 5756 ODl ASN B 373 28.754 -19.305 7.300 1.00 16.35 O

ATOM 5757 ND2 ASN B 373 29.687 -21.336 7.579 1.00 17.15 N

ATOM 5758 C ASN B 373 27.868 -19.314 10.527 1.00 13.04 C

ATOM 5759 O ASN B 373 27.412 -20.292 9.936 1.00 13.27 O

ATOM 5760 N GLN B 374 27.259 -18.754 11.570 1.00 12.83 N

ATOM 5761 CA GLN B 374 26.059 -19.330 12.168 1.00 12.71 C

ATOM 5762 CB GLN B 374 26.345 -19.754 13.608 1.00 12.61 C

ATOM 5763 CG GLN B 374 27.239 -20.971 13.760 1.00 13.00 C

ATOM 5764 CD GLN B 374 27.516 -21.300 15.215 1.00 13.04 C

ATOM 5765 OEl GLN B 374 27.847 -20.417 16.007 1.00 13.73 O

ATOM 5766 NE2 GLN B 374 27.378 -22.574 15.575 1.00 12.97 N

ATOM 5767 C GLN B 374 24.862 -18.373 12.141 1.00 12.62 C

ATOM 5768 O GLN B 374 23.880 -18.584 12.858 1.00 12.48 O

ATOM 5769 N GLY B 375 24.944 -17.335 11.305 1.00 12.49 N

ATOM 5770 CA GLY B 375 23.928 -16.279 11.269 1.00 12.20 C

ATOM 5771 C GLY B 375 24.129 -15.252 12.375 1.00 11.89 C

ATOM 5772 O GLY B 375 25.049 -15.371 13.192 1.00 11.85 O

ATOM 5773 N LYS B 376 23.259 -14.246 12.406 1.00 11.62 N

ATOM 5774 CA LYS B 376 23.327 -13.185 13.412 1.00 11.39 C

ATOM 5775 CB LYS B 376 22.619 -11.922 12.914 1.00 11.59 C W2025-7029WO / AM102903-PCT

ATOM 5776 CG LYS B 376 23.158 -11.399 11.588 1.00 12.71 C

ATOM 5777 CD LYS B 376 22.657 -10.002 11.278 1.00 15.23 C

ATOM 5778 CE LYS B 376 23.154 -9.531 9.915 1.00 16.73 C

ATOM 5779 NZ LYS B 376 22.765 -8.116 9.633 1.00 18.99 N

ATOM 5780 C LYS B 376 22.730 -13.656 14.738 1.00 10.84 C

ATOM 5781 O LYS B 376 21.689 -14.319 14.755 1.00 10.98 O

ATOM 5782 N PHE B 377 23.395 -13.306 15.841 1.00 10.24 N

ATOM 5783 CA PHE B 377 23.009 -13.759 17.188 1.00 9.34 C

ATOM 5784 CB PHE B 377 21.753 -13.019 17.687 1.00 9.71 C

ATOM 5785 CG PHE B 377 21.912 -11.522 17.816 1.00 9.70 C

ATOM 5786 CDl PHE B 377 22.568 -10.967 18.912 1.00 9.89 C

ATOM 5787 CEl PHE B 377 22.694 -9.580 19.047 1.00 10.45 C

ATOM 5788 CZ PHE B 377 22.145 -8.734 18.083 1.00 10.26 C

ATOM 5789 CE2 PHE B 377 21.468 -9.281 16.988 1.00 10.64 C

ATOM 5790 CD2 PHE B 377 21.350 -10.669 16.867 1.00 10.15 C

ATOM 5791 C PHE B 377 22.761 -15.281 17.266 1.00 8.89 C

ATOM 5792 O PHE B 377 21.665 -15.699 17.638 1.00 8.14 O

ATOM 5793 N PRO B 378 23.775 -16.110 16.925 1.00 8.38 N

ATOM 5794 CA PRO B 378 23.554 -17.560 16.892 1.00 8.27 C

ATOM 5795 CB PRO B 378 24.898 -18.117 16.392 1.00 8.21 C

ATOM 5796 CG PRO B 378 25.894 -17.060 16.692 1.00 8.08 C

ATOM 5797 CD PRO B 378 25.159 -15.761 16.552 1.00 8.43 C

ATOM 5798 C PRO B 378 23.173 -18.169 18.253 1.00 8.32 C

ATOM 5799 O PRO B 378 22.294 -19.035 18.315 1.00 8.27 O

ATOM 5800 N LEU B 379 23.809 -17.703 19.325 1.00 8.05 N

ATOM 5801 CA LEU B 379 23.552 -18.229 20.663 1.00 8.04 C

ATOM 5802 CB LEU B 379 24.667 -17.826 21.630 1.00 7.79 C

ATOM 5803 CG LEU B 379 26.060 -18.392 21.359 1.00 7.65 C

ATOM 5804 CDl LEU B 379 27.012 -18.016 22.487 1.00 6.95 C

ATOM 5805 CD2 LEU B 379 25.999 -19.907 21.183 1.00 8.14 C

ATOM 5806 C LEU B 379 22.191 -17.822 21.222 1.00 8.35 C

ATOM 5807 O LEU B 379 21.444 -18.667 21.718 1.00 8.55 O

ATOM 5808 N ILE B 380 21.869 -16.532 21.141 1.00 8.61 N

ATOM 5809 CA ILE B 380 20.583 -16.033 21.645 1.00 9.08 C

ATOM 5810 CB ILE B 380 20.590 -14.495 21.841 1.00 9.12 C

ATOM 5811 CGl ILE B 380 21.693 -14.107 22.839 1.00 9.43 C

ATOM 5812 CDl ILE B 380 21.947 -12.609 22.940 1.00 9.43 C

ATOM 5813 CG2 ILE B 380 19.230 -14.006 22.348 1.00 9.35 C

ATOM 5814 C ILE B 380 19.402 -16.505 20.777 1.00 9.08 C

ATOM 5815 O ILE B 380 18.338 -16.846 21.307 1.00 8.92 O

ATOM 5816 N SER B 381 19.603 -16.546 19.459 1.00 9.06 N

ATOM 5817 CA SER B 381 18.604 -17.114 18.541 1.00 9.49 C

ATOM 5818 CB SER B 381 19.067 -17.032 17.083 1.00 9.32 C

ATOM 5819 OG SER B 381 19.199 -15.679 16.676 1.00 10.47 O

ATOM 5820 C SER B 381 18.251 -18.555 18.904 1.00 9.38 C

ATOM 5821 O SER B 381 17.081 -18.940 18.852 1.00 9.59 O

ATOM 5822 N THR B 382 19.266 -19.338 19.279 1.00 9.47 N

ATOM 5823 CA THR B 382 19.079 -20.703 19.781 1.00 9.50 C

ATOM 5824 CB THR B 382 20.414 -21.302 20.287 1.00 9.76 C

ATOM 5825 OGl THR B 382 21.364 -21.335 19.216 1.00 9.97 O

ATOM 5826 CG2 THR B 382 20.216 -22.713 20.841 1.00 10.06 C

ATOM 5827 C THR B 382 18.059 -20.740 20.923 1.00 9.46 C

ATOM 5828 O THR B 382 17.188 -21.613 20.960 1.00 8.98 O

ATOM 5829 N LEU B 383 18.183 -19.791 21.848 1.00 9.52 N

ATOM 5830 CA LEU B 383 17.296 -19.709 23.002 1.00 10.11 C

ATOM 5831 CB LEU B 383 17.880 -18.789 24.083 1.00 9.69 C

ATOM 5832 CG LEU B 383 19.236 -19.198 24.677 1.00 9.37 C

ATOM 5833 CDl LEU B 383 19.653 -18.253 25.805 1.00 8.41 C

ATOM 5834 CD2 LEU B 383 19.204 -20.636 25.170 1.00 8.56 C

ATOM 5835 C LEU B 383 15.887 -19.277 22.623 1.00 10.64 C

ATOM 5836 O LEU B 383 14.917 -19.895 23.066 1.00 10.70 O

ATOM 5837 N LYS B 384 15.777 -18.221 21.813 1.00 11.46 N

ATOM 5838 CA LYS B 384 14.472 -17.750 21.324 1.00 12.33 C W2025-7029WO / AM102903-PCT

ATOM 5839 CB LYS B 384 14.626 -16.619 20.292 1.00 12.41 C

ATOM 5840 CG LYS B 384 13.459 -16.533 19.282 1.00 13.91 C

ATOM 5841 CD LYS B 384 13.276 -15.143 18.722 1.00 16.30 C

ATOM 5842 CE LYS B 384 12.571 -15.157 17.362 1.00 17.90 C

ATOM 5843 NZ LYS B 384 11.397 -16.073 17.269 1.00 17.44 N

ATOM 5844 C LYS B 384 13.649 -18.899 20.740 1.00 12.62 C

ATOM 5845 O LYS B 384 12.490 -19.089 21.111 1.00 12.58 O

ATOM 5846 N LYS B 385 14.266 -19.659 19.838 1.00 13.16 N

ATOM 5847 CA LYS B 385 13.620 -20.803 19.201 1.00 14.02 C

ATOM 5848 CB LYS B 385 14.529 -21.407 18.125 1.00 14.37 C

ATOM 5849 CG LYS B 385 13.939 -22.628 17.432 1.00 16.63 C

ATOM 5850 CD LYS B 385 14.973 -23.351 16.580 1.00 20.20 C

ATOM 5851 CE LYS B 385 14.409 -24.651 16.024 1.00 21.79 C

ATOM 5852 NZ LYS B 385 15.085 -25.045 14.750 1.00 23.43 N

ATOM 5853 C LYS B 385 13.233 -21.870 20.222 1.00 13.76 C

ATOM 5854 O LYS B 385 12.100 -22.360 20.215 1.00 13.83 O

ATOM 5855 N ALA B 386 14.178 -22.215 21.098 1.00 13.65 N

ATOM 5856 CA ALA B 386 13.974 -23.261 22.097 1.00 13.53 C

ATOM 5857 CB ALA B 386 15.260 -23.521 22.860 1.00 13.68 C

ATOM 5858 C ALA B 386 12.840 -22.932 23.067 1.00 13.44 C

ATOM 5859 O ALA B 386 12.058 -23.809 23.427 1.00 13.29 O

ATOM 5860 N LEU B 387 12.747 -21.664 23.462 1.00 13.25 N

ATOM 5861 CA LEU B 387 11.764 -21.223 24.457 1.00 12.95 C

ATOM 5862 CB LEU B 387 12.355 -20.104 25.319 1.00 12.92 C

ATOM 5863 CG LEU B 387 13.589 -20.491 26.154 1.00 12.81 C

ATOM 5864 CDl LEU B 387 14.264 -19.256 26.751 1.00 12.28 C

ATOM 5865 CD2 LEU B 387 13.247 -21.508 27.251 1.00 12.57 C

ATOM 5866 C LEU B 387 10.419 -20.813 23.840 1.00 13.06 C

ATOM 5867 O LEU B 387 9.476 -20.460 24.557 1.00 12.87 O

ATOM 5868 N GLY B 388 10.347 -20.877 22.511 1.00 12.98 N

ATOM 5869 CA GLY B 388 9.098 -20.707 21.767 1.00 13.17 C

ATOM 5870 C GLY B 388 8.530 -19.301 21.741 1.00 13.02 C

ATOM 5871 O GLY B 388 7.306 -19.125 21.707 1.00 13.05 O

ATOM 5872 N LEU B 389 9.412 -18.300 21.737 1.00 12.94 N

ATOM 5873 CA LEU B 389 8.986 -16.892 21.767 1.00 12.68 C

ATOM 5874 CB LEU B 389 10.175 -15.941 21.954 1.00 12.33 C

ATOM 5875 CG LEU B 389 11.180 -16.185 23.088 1.00 11.99 C

ATOM 5876 CDl LEU B 389 12.113 -14.993 23.196 1.00 10.10 C

ATOM 5877 CD2 LEU B 389 10.511 -16.473 24.439 1.00 11.98 C

ATOM 5878 C LEU B 389 8.190 -16.506 20.527 1.00 12.88 C

ATOM 5879 O LEU B 389 8.480 -16.956 19.414 1.00 12.64 O

ATOM 5880 N GLN B 390 7.172 -15.679 20.745 1.00 13.10 N

ATOM 5881 CA GLN B 390 6.281 -15.223 19.682 1.00 13.48 C

ATOM 5882 CB GLN B 390 5.244 -16.304 19.316 1.00 13.25 C

ATOM 5883 CG GLN B 390 4.346 -16.755 20.480 1.00 15.05 C

ATOM 5884 CD GLN B 390 3.285 -17.779 20.082 1.00 15.83 C

ATOM 5885 OEl GLN B 390 3.433 -18.513 19.094 1.00 18.98 O

ATOM 5886 NE2 GLN B 390 2.206 -17.842 20.868 1.00 18.54 N

ATOM 5887 C GLN B 390 5.582 -13.938 20.108 1.00 12.52 C

ATOM 5888 O GLN B 390 5.184 -13.787 21.265 1.00 12.20 O

ATOM 5889 N SER B 391 5.459 -13.009 19.169 1.00 11.93 N

ATOM 5890 CA SER B 391 4.619 -11.827 19.352 1.00 11.53 C

ATOM 5891 CB SER B 391 5.386 -10.683 20.035 1.00 11.42 C

ATOM 5892 OG SER B 391 6.254 -10.015 19.137 1.00 11.90 O

ATOM 5893 C SER B 391 4.065 -11.387 18.003 1.00 11.01 C

ATOM 5894 O SER B 391 4.723 -11.564 16.966 1.00 10.75 O

ATOM 5895 N ALA B 392 2.858 -10.825 18.025 1.00 10.67 N

ATOM 5896 CA ALA B 392 2.196 -10.319 16.816 1.00 10.72 C

ATOM 5897 CB ALA B 392 0.837 -9.710 17.164 1.00 10.69 C

ATOM 5898 C ALA B 392 3.054 -9.318 16.029 1.00 10.51 C

ATOM 5899 O ALA B 392 3.138 -9.406 14.802 1.00 10.87 O

ATOM 5900 N SER B 393 3.693 -8.386 16.741 1.00 10.17 N

ATOM 5901 CA SER B 393 4.601 -7.399 16.142 1.00 9.78 C W2025-7029WO / AM102903-PCT

ATOM 5902 CB SER B 393 5.279 -6.558 17.229 1.00 9.84 C

ATOM 5903 OG SER B 393 4.342 -5.872 18.032 1.00 10.08 O

ATOM 5904 C SER B 393 5.697 -8.046 15.303 1.00 9.56 C

ATOM 5905 O SER B 393 6.121 -7.490 14.290 1.00 9.28 O

ATOM 5906 N CYS B 394 6.156 -9.213 15.750 1.00 9.38 N

ATOM 5907 CA CYS B 394 7.277 -9.911 15.128 1.00 9.24 C

ATOM 5908 CB CYS B 394 8.193 -10.494 16.208 1.00 8.99 C

ATOM 5909 SG CYS B 394 8.917 -9.197 17.256 1.00 9.24

ATOM 5910 C CYS B 394 6.785 -10.983 14.156 1.00 9.27 C

ATOM 5911 O CYS B 394 7.201 -12.140 14.218 1.00 9.72 O

ATOM 5912 N THR B 395 5.854 -10.582 13.292 1.00 8.86 N

ATOM 5913 CA THR B 395 5.372 -11.396 12.184 1.00 8.33 C

ATOM 5914 CB THR B 395 3.973 -12.030 12.462 1.00 8.42 C

ATOM 5915 OGl THR B 395 2.982 -11.001 12.589 1.00 8.01 O

ATOM 5916 CG2 THR B 395 3.984 -12.886 13.729 1.00 7.76 C

ATOM 5917 C THR B 395 5.295 -10.484 10.967 1.00 8.22 C

ATOM 5918 O THR B 395 5.447 -9.261 11.094 1.00 8.24 O

ATOM 5919 N ALA B 396 5.064 -11.072 9.795 1.00 7.86 N

ATOM 5920 CA ALA B 396 5.016 -10.319 8.549 1.00 7.86 C

ATOM 5921 CB ALA B 396 6.361 -10.408 7.809 1.00 7.76 C

ATOM 5922 C ALA B 396 3.862 -10.791 7.658 1.00 7.97 C

ATOM 5923 O ALA B 396 4.063 -11.626 6.769 1.00 7.51 O

ATOM 5924 N PRO B 397 2.647 -10.254 7.899 1.00 8.14 N

ATOM 5925 CA PRO B 397 1.450 -10.632 7.136 1.00 8.13 C

ATOM 5926 CB PRO B 397 0.303 -9.916 7.873 1.00 8.09 C

ATOM 5927 CG PRO B 397 0.889 -9.404 9.153 1.00 8.64 C

ATOM 5928 CD PRO B 397 2.348 -9.221 8.907 1.00 8.27 C

ATOM 5929 C PRO B 397 1.520 -10.137 5.693 1.00 8.24 C

ATOM 5930 O PRO B 397 2.431 -9.372 5.336 1.00 7.65 O

ATOM 5931 N ALA B 398 0.554 -10.567 4.883 1.00 8.23 N

ATOM 5932 CA ALA B 398 0.478 -10.189 3.471 1.00 8.66 C

ATOM 5933 CB ALA B 398 -0.318 -11.232 2.678 1.00 8.27 C

ATOM 5934 C ALA B 398 -0.105 -8.784 3.296 1.00 8.92 C

ATOM 5935 O ALA B 398 -1.118 -8.581 2.619 1.00 8.92 O

ATOM 5936 N GLN B 399 0.543 -7.821 3.946 1.00 9.77 N

ATOM 5937 CA GLN B 399 0.230 -6.400 3.816 1.00 10.38 C

ATOM 5938 CB GLN B 399 -0.602 -5.919 5.011 1.00 10.22 C

ATOM 5939 CG GLN B 399 -1.966 -6.616 5.124 1.00 9.36 C

ATOM 5940 CD GLN B 399 -2.750 -6.262 6.374 1.00 9.59 C

ATOM 5941 OEl GLN B 399 -3.257 -7.147 7.072 1.00 7.44 O

ATOM 5942 NE2 GLN B 399 -2.875 -4.971 6.654 1.00 6.76 N

ATOM 5943 C GLN B 399 1.571 -5.667 3.725 1.00 11.45 C

ATOM 5944 O GLN B 399 2.535 -6.066 4.383 1.00 12.08 O

ATOM 5945 N PRO B 400 1.658 -4.606 2.905 1.00 12.22 N

ATOM 5946 CA PRO B 400 2.982 -3.996 2.740 1.00 12.53 C

ATOM 5947 CB PRO B 400 2.909 -3.364 1.344 1.00 12.69 C

ATOM 5948 CG PRO B 400 1.424 -3.238 1.020 1.00 12.92 C

ATOM 5949 CD PRO B 400 0.627 -3.895 2.128 1.00 12.39 C

ATOM 5950 C PRO B 400 3.295 -2.937 3.799 1.00 12.64 C

ATOM 5951 O PRO B 400 2.764 -2.990 4.913 1.00 12.64 O

ATOM 5952 N TYR C 22 29.962 -22.117 58.165 1.00 14.39 N

ATOM 5953 CA TYR C 22 28.554 -21.672 58.397 1.00 14.14 C

ATOM 5954 CB TYR C 22 27.558 -22.736 57.914 1.00 14.33 C

ATOM 5955 CG TYR C 22 27.734 -24.072 58.592 1.00 14.16 C

ATOM 5956 CDl TYR C 22 28.381 -25.122 57.942 1.00 14.12 C

ATOM 5957 CEl TYR C 22 28.555 -26.355 58.566 1.00 14.48 C

ATOM 5958 CZ TYR C 22 28.083 -26.539 59.856 1.00 14.76 C

ATOM 5959 OH TYR C 22 28.257 -27.751 60.481 1.00 15.71 O

ATOM 5960 CE2 TYR C 22 27.440 -25.508 60.529 1.00 14.77 C

ATOM 5961 CD2 TYR C 22 27.270 -24.280 59.892 1.00 14.04 C

ATOM 5962 C TYR C 22 28.264 -20.349 57.707 1.00 14.11 C

ATOM 5963 O TYR C 22 28.835 -20.049 56.650 1.00 14.23 O

ATOM 5964 N GLN C 23 27.383 -19.561 58.321 1.00 13.72 N W2025-7029WO / AM102903-PCT

ATOM 5965 CA GLN C 23 26.898 -18.316 57.727 1.00 13.57 C

ATOM 5966 CB GLN C 23 26.937 -17.159 58.738 1.00 13.77 C

ATOM 5967 CG GLN C 23 28.246 -17.005 59.534 1.00 15.22 C

ATOM 5968 CD GLN C 23 29.462 -16.643 58.683 1.00 18.35 C

ATOM 5969 OEl GLN C 23 29.347 -16.319 57.495 1.00 19.62 O

ATOM 5970 NE2 GLN C 23 30.643 -16.700 59.298 1.00 19.31 N

ATOM 5971 C GLN C 23 25.468 -18.525 57.238 1.00 12.90 C

ATOM 5972 O GLN C 23 24.720 -19.307 57.827 1.00 12.64 O

ATOM 5973 N LEU C 24 25.106 -17.843 56.154 1.00 12.33 N

ATOM 5974 CA LEU C 24 23.722 -17.804 55.675 1.00 12.15 C

ATOM 5975 CB LEU C 24 23.560 -18.555 54.347 1.00 12.28 C

ATOM 5976 CG LEU C 24 22.183 -18.603 53.661 1.00 12.23 C

ATOM 5977 CDl LEU C 24 21.049 -18.957 54.629 1.00 12.25 C

ATOM 5978 CD2 LEU C 24 22.207 -19.591 52.498 1.00 12.38 C

ATOM 5979 C LEU C 24 23.289 -16.346 55.549 1.00 12.19 C

ATOM 5980 O LEU C 24 23.752 -15.611 54.667 1.00 11.88 O

ATOM 5981 N THR C 25 22.405 -15.936 56.452 1.00 11.92 N

ATOM 5982 CA THR C 25 22.070 -14.530 56.610 1.00 11.86 C

ATOM 5983 CB THR C 25 22.311 -14.090 58.062 1.00 11.77 C

ATOM 5984 OGl THR C 25 23.688 -14.310 58.394 1.00 11.72 O

ATOM 5985 CG2 THR C 25 21.990 -12.619 58.247 1.00 11.97 C

ATOM 5986 C THR C 25 20.631 -14.269 56.177 1.00 11.96 C

ATOM 5987 O THR C 25 19.700 -14.848 56.728 1.00 12.08 O

ATOM 5988 N CYS C 26 20.458 -13.400 55.184 1.00 11.92 N

ATOM 5989 CA CYS C 26 19.146 -13.190 54.572 1.00 11.67 C

ATOM 5990 CB CYS C 26 19.198 -13.570 53.088 1.00 11.83 C

ATOM 5991 SG CYS C 26 19.863 -15.236 52.802 1.00 12.83

ATOM 5992 C CYS C 26 18.622 -11.766 54.754 1.00 11.29 C

ATOM 5993 O CYS C 26 19.269 -10.802 54.349 1.00 10.86 O

ATOM 5994 N TYR C 27 17.450 -11.652 55.378 1.00 11.04 N

ATOM 5995 CA TYR C 27 16.774 -10.367 55.560 1.00 10.69 C

ATOM 5996 CB TYR C 27 15.774 -10.436 56.720 1.00 10.26 C

ATOM 5997 CG TYR C 27 16.391 -10.420 58.102 1.00 10.07 C

ATOM 5998 CDl TYR C 27 16.495 -9.234 58.827 1.00 9.59 C

ATOM 5999 CEl TYR C 27 17.058 -9.215 60.105 1.00 9.83 C

ATOM 6000 CZ TYR C 27 17.514 -10.399 60.668 1.00 10.02 C

ATOM 6001 OH TYR C 27 18.074 -10.396 61.927 1.00 9.78 O

ATOM 6002 CE2 TYR C 27 17.421 -11.588 59.966 1.00 10.09 C

ATOM 6003 CD2 TYR C 27 16.855 -11.595 58.694 1.00 10.39 C

ATOM 6004 C TYR C 27 16.048 -9.910 54.297 1.00 10.78 C

ATOM 6005 O TYR C 27 15.218 -10.643 53.747 1.00 10.97 O

ATOM 6006 N PHE C 28 16.371 -8.696 53.850 1.00 10.76 N

ATOM 6007 CA PHE C 28 15.630 -8.011 52.792 1.00 10.51 C

ATOM 6008 CB PHE C 28 16.586 -7.348 51.792 1.00 10.54 C

ATOM 6009 CG PHE C 28 15.939 -6.270 50.954 1.00 10.80 C

ATOM 6010 CDl PHE C 28 15.205 -6.599 49.815 1.00 10.14 C

ATOM 6011 CEl PHE C 28 14.599 -5.611 49.042 1.00 10.58 C

ATOM 6012 CZ PHE C 28 14.719 -4.274 49.409 1.00 11.19 C

ATOM 6013 CE2 PHE C 28 15.448 -3.931 50.553 1.00 11.67 C

ATOM 6014 CD2 PHE C 28 16.051 -4.929 51.317 1.00 10.69 C

ATOM 6015 C PHE C 28 14.728 -6.963 53.426 1.00 10.35 C

ATOM 6016 O PHE C 28 15.147 -6.263 54.350 1.00 10.30 O

ATOM 6017 N THR C 29 13.498 -6.848 52.926 1.00 10.14 N

ATOM 6018 CA THR C 29 12.527 -5.912 53.511 1.00 10.08 C

ATOM 6019 CB THR C 29 11.275 -6.642 54.061 1.00 9.97 C

ATOM 6020 OGl THR C 29 10.514 -7.192 52.982 1.00 9.52 O

ATOM 6021 CG2 THR C 29 11.679 -7.767 55.034 1.00 9.63 C

ATOM 6022 C THR C 29 12.127 -4.769 52.570 1.00 10.20 C

ATOM 6023 O THR C 29 11.752 -4.997 51.412 1.00 9.99 O

ATOM 6024 N ASN C 30 12.206 -3.544 53.091 1.00 10.30 N

ATOM 6025 CA ASN C 30 11.982 -2.326 52.301 1.00 10.77 C

ATOM 6026 CB ASN C 30 12.731 -1.117 52.905 1.00 10.44 C

ATOM 6027 CG ASN C 30 12.136 -0.630 54.230 1.00 10.96 C W2025-7029WO / AM102903-PCT

ATOM 6028 ODl ASN C 30 11.260 -1.268 54.823 1.00 10.99 O

ATOM 6029 ND2 ASN C 30 12.624 0.515 54.698 1.00 9.17 N

ATOM 6030 C ASN C 30 10.513 -1.989 51.993 1.00 10.77 C

ATOM 6031 O ASN C 30 10.224 -0.938 51.415 1.00 11.27 O

ATOM 6032 N TRP C 31 -9.596 -2.873 52.376 1.00 10.77 N

ATOM 6033 CA TRP C 31 -8.190 -2.726 52.000 1.00 10.60 C

ATOM 6034 CB TRP C 31 -7.269 -2.877 53.216 1.00 10.51 C

ATOM 6035 CG TRP C 31 -7.358 -4.199 53.942 1.00 10.80 C

ATOM 6036 CDl TRP C 31 -6.612 -5.320 53.699 1.00 10.78 C

ATOM 6037 NEl TRP C 31 -6.957 -6.322 54.577 1.00 10.00 N

ATOM 6038 CE2 TRP C 31 -7.945 -5.864 55.409 1.00 10.25 C

ATOM 6039 CD2 TRP C 31 -8.220 -4.525 55.045 1.00 10.34 C

ATOM 6040 CE3 TRP C 31 -9.203 -3.819 55.755 1.00 10.37 C

ATOM 6041 CZ3 TRP C 31 -9.872 -4.466 56.796 1.00 10.18 C

ATOM 6042 CH2 TRP C 31 -9.572 -5.797 57.136 1.00 10.21 C

ATOM 6043 CZ2 TRP C 31 -8.614 -6.512 56.457 1.00 10.10 C

ATOM 6044 C TRP C 31 -7.776 -3.675 50.865 1.00 10.90 C

ATOM 6045 O TRP C 31 -6.678 -3.541 50.302 1.00 10.34 O

ATOM 6046 N ALA C 32 -8.657 -4.620 50.525 1.00 10.85 N

ATOM 6047 CA ALA C 32 -8.400 -5.572 49.435 1.00 11.40 C

ATOM 6048 CB ALA C 32 -9.457 -6.662 49.415 1.00 11.37 C

ATOM 6049 C ALA C 32 -8.311 -4.888 48.063 1.00 11.77 C

ATOM 6050 O ALA C 32 -7.750 -5.445 47.117 1.00 11.74 O

ATOM 6051 N GLN C 33 -8.863 -3.678 47.977 1.00 12.46 N

ATOM 6052 CA GLN C 33 -8.834 -2.868 46.757 1.00 13.11 C

ATOM 6053 CB GLN C 33 -9.701 -1.615 46.932 1.00 12.93 C

ATOM 6054 CG GLN C 33 -9.285 -0.709 48.090 1.00 13.68 C

ATOM 6055 CD GLN C 33 -9.877 0.685 47.986 1.00 13.50 C

ATOM 6056 OEl GLN C 33 -9.910 1.283 46.903 1.00 14.86 O

ATOM 6057 NE2 GLN C 33 10.339 1.215 49.113 1.00 12.22 N

ATOM 6058 C GLN C 33 -7.416 -2.458 46.341 1.00 13.38 C

ATOM 6059 O GLN C 33 -7.190 -2.071 45.192 1.00 13.57 O

ATOM 6060 N TYR C 34 -6.472 -2.542 47.276 1.00 13.77 N

ATOM 6061 CA TYR C 34 -5.102 -2.093 47.029 1.00 14.38 C

ATOM 6062 CB TYR C 34 -4.542 -1.372 48.261 1.00 14.63 C

ATOM 6063 CG TYR C 34 -5.355 -0.155 48.663 1.00 15.02 C

ATOM 6064 CDl TYR C 34 -5.552 0.901 47.768 1.00 15.22 C

ATOM 6065 CEl TYR C 34 -6.303 2.009 48.123 1.00 14.88 C

ATOM 6066 CZ TYR C 34 -6.863 2.077 49.384 1.00 15.06 C

ATOM 6067 OH TYR C 34 -7.603 3.185 49.735 1.00 15.60 O

ATOM 6068 CE2 TYR C 34 -6.683 1.043 50.295 1.00 14.92 C

ATOM 6069 CD2 TYR C 34 -5.934 -0.064 49.929 1.00 14.53 C

ATOM 6070 C TYR C 34 -4.161 -3.203 46.566 1.00 14.52 C

ATOM 6071 O TYR C 34 -3.017 -2.933 46.211 1.00 14.76 O

ATOM 6072 N ARG C 35 -4.659 -4.439 46.559 1.00 14.53 N

ATOM 6073 CA ARG C 35 -3.885 -5.612 46.153 1.00 14.58 C

ATOM 6074 CB ARG C 35 -4.598 -6.897 46.598 1.00 14.22 C

ATOM 6075 CG ARG C 35 -4.726 -6.988 48.112 1.00 14.42 C

ATOM 6076 CD ARG C 35 -5.303 -8.304 48.608 1.00 14.38 C

ATOM 6077 NE ARG C 35 -5.507 -8.227 50.054 1.00 12.83 N

ATOM 6078 CZ ARG C 35 -6.482 -8.836 50.725 1.00 12.44 C

ATOM 6079 NHl ARG C 35 -7.371 -9.595 50.096 1.00 11.21 N

ATOM 6080 NH2 ARG C 35 -6.570 -8.673 52.041 1.00 11.15 N

ATOM 6081 C ARG C 35 -3.613 -5.620 44.641 1.00 14.95 C

ATOM 6082 O ARG C 35 -4.496 -5.277 43.850 1.00 14.99 O

ATOM 6083 N PRO C 36 -2.387 -6.009 44.238 1.00 15.12 N

ATOM 6084 CA PRO C 36 -2.007 -5.927 42.826 1.00 15.17 C

ATOM 6085 CB PRO C 36 -0.496 -6.157 42.862 1.00 15.15 C

ATOM 6086 CG PRO C 36 -0.288 -7.020 44.064 1.00 15.09 C

ATOM 6087 CD PRO C 36 -1.295 -6.548 45.072 1.00 14.97 C

ATOM 6088 C PRO C 36 -2.675 -6.992 41.955 1.00 15.23 C

ATOM 6089 O PRO C 36 -2.975 -8.089 42.435 1.00 15.33 O

ATOM 6090 N GLY C 37 -2.896 -6.650 40.687 1.00 15.17 N W2025-7029WO / AM102903-PCT

ATOM 6091 CA GLY C 37 -3.415 -7.576 39.680 1.00 15.21 C

ATOM 6092 C GLY C 37 -4.609 -8.407 40.103 1.00 15.26 C

ATOM 6093 O GLY C 37 -5.600 -7.880 40.613 1.00 15.19 O

ATOM 6094 N LEU C 38 -4.492 -9.718 39.900 1.00 15.20 N

ATOM 6095 CA LEU C 38 -5.555 -10.674 40.206 1.00 15.23 C

ATOM 6096 CB LEU C 38 -5.151 -12.082 39.746 1.00 15.35 C

ATOM 6097 CG LEU C 38 -5.015 -12.310 38.231 1.00 15.91 C

ATOM 6098 CDl LEU C 38 -4.413 -13.679 37.937 1.00 15.92 C

ATOM 6099 CD2 LEU C 38 -6.354 -12.142 37.515 1.00 16.50 C

ATOM 6100 C LEU C 38 -5.984 -10.696 41.678 1.00 14.89 C

ATOM 6101 O LEU C 38 -7.033 -11.246 42.011 1.00 15.33 O

ATOM 6102 N GLY C 39 -5.176 -10.092 42.544 1.00 14.58 N

ATOM 6103 CA GLY C 39 -5.507 -9.963 43.963 1.00 14.18 C

ATOM 6104 C GLY C 39 -6.538 -8.893 44.287 1.00 13.80 C

ATOM 6105 O GLY C 39 -7.242 -8.997 45.299 1.00 13.55 O

ATOM 6106 N ARG C 40 -6.623 -7.861 43.444 1.00 13.34 N

ATOM 6107 CA ARG C 40 -7.560 -6.746 43.654 1.00 13.58 C

ATOM 6108 CB ARG C 40 -7.431 -5.699 42.541 1.00 13.47 C

ATOM 6109 CG ARG C 40 -8.321 -4.466 42.715 1.00 14.52 C

ATOM 6110 CD ARG C 40 -8.021 -3.412 41.647 1.00 15.08 C

ATOM 6111 NE ARG C 40 -9.144 -2.495 41.424 1.00 18.59 N

ATOM 6112 CZ ARG C 40 -9.299 -1.319 42.031 1.00 20.11 C

ATOM 6113 NHl ARG C 40 10.353 -0.562 41.747 1.00 20.79 N

ATOM 6114 NH2 ARG C 40 -8.409 -0.893 42.922 1.00 20.27 N

ATOM 6115 C ARG C 40 -9.000 -7.240 43.763 1.00 12.77 C

ATOM 6116 O ARG C 40 -9.468 -7.990 42.910 1.00 12.39 O

ATOM 6117 N PHE C 41 -9.684 -6.822 44.827 1.00 12.52 N

ATOM 6118 CA PHE C 41 11.058 -7.257 45.090 1.00 12.24 C

ATOM 6119 CB PHE C 41 11.081 -8.361 46.162 1.00 11.97 C

ATOM 6120 CG PHE C 41 12.421 -9.056 46.306 1.00 11.65 C

ATOM 6121 CDl PHE C 41 12.689 -10.227 45.604 1.00 11.23 C

ATOM 6122 CEl PHE C 41 13.913 -10.880 45.737 1.00 11.37 C

ATOM 6123 CZ PHE C 41 14.888 -10.358 46.582 1.00 11.21 C

ATOM 6124 CE2 PHE C 41 14.632 -9.192 47.292 1.00 11.14 C

ATOM 6125 CD2 PHE C 41 13.404 -8.546 47.152 1.00 10.96 C

ATOM 6126 C PHE C 41 11.940 -6.072 45.502 1.00 12.37 C

ATOM 6127 O PHE C 41 11.669 -5.394 46.496 1.00 12.14 O

ATOM 6128 N MET C 42 12.991 -5.847 44.717 1.00 12.64 N

ATOM 6129 CA MET C 42 13.949 -4.762 44.916 1.00 13.18 C

ATOM 6130 CB MET C 42 14.048 -3.912 43.642 1.00 13.34 C

ATOM 6131 CG MET C 42 12.721 -3.370 43.123 1.00 14.50 C

ATOM 6132 SD MET C 42 11.891 -2.255 44.271 1.00 17.11

ATOM 6133 CE MET C 42 12.818 -0.738 44.062 1.00 15.92 C

ATOM 6134 C MET C 42 15.329 -5.348 45.249 1.00 13.27 C

ATOM 6135 O MET C 42 15.556 -6.539 45.031 1.00 12.88 O

ATOM 6136 N PRO C 43 16.260 -4.517 45.773 1.00 13.45 N

ATOM 6137 CA PRO C 43 17.614 -5.010 46.062 1.00 13.79 C

ATOM 6138 CB PRO C 43 18.371 -3.734 46.444 1.00 13.73 C

ATOM 6139 CG PRO C 43 17.319 -2.864 47.035 1.00 13.42 C

ATOM 6140 CD PRO C 43 16.114 -3.102 46.165 1.00 13.22 C

ATOM 6141 C PRO C 43 18.302 -5.718 44.888 1.00 14.35 C

ATOM 6142 O PRO C 43 19.059 -6.665 45.109 1.00 14.42 O

ATOM 6143 N ASP C 44 18.030 -5.277 43.660 1.00 14.70 N

ATOM 6144 CA ASP C 44 18.642 -5.882 42.472 1.00 15.26 C

ATOM 6145 CB ASP C 44 18.663 -4.892 41.298 1.00 15.50 C

ATOM 6146 CG ASP C 44 19.751 -3.835 41.445 1.00 16.79 C

ATOM 6147 ODl ASP C 44 20.901 -4.197 41.777 1.00 18.67 O

ATOM 6148 OD2 ASP C 44 19.463 -2.638 41.226 1.00 18.30 O

ATOM 6149 C ASP C 44 18.005 -7.220 42.071 1.00 15.10 C

ATOM 6150 O ASP C 44 18.470 -7.881 41.135 1.00 14.98 O

ATOM 6151 N ASP C 45 16.957 -7.618 42.791 1.00 14.86 N

ATOM 6152 CA ASP C 45 16.368 -8.949 42.637 1.00 14.87 C

ATOM 6153 CB ASP C 45 14.874 -8.922 42.961 1.00 15.03 C W2025-7029WO / AM102903-PCT

ATOM 6154 CG ASP C 45 14.084 -8.086 41.978 1.00 14.99 C

ATOM 6155 ODl ASP C 45 14.251 -8.287 40.755 1.00 15.93 O

ATOM 6156 OD2 ASP C 45 13.301 -7.233 42.431 1.00 14.09 O

ATOM 6157 C ASP C 45 17.076 -9.999 43.492 1.00 14.83 C

ATOM 6158 O ASP C 45 16.809 -11.196 43.358 1.00 15.06 O

ATOM 6159 N ILE C 46 17.979 -9.543 44.359 1.00 14.64 N

ATOM 6160 CA ILE C 46 18.799 -10.427 45.185 1.00 14.46 C

ATOM 6161 CB ILE C 46 19.360 -9.686 46.437 1.00 14.37 C

ATOM 6162 CGl ILE C 46 18.221 -9.161 47.318 1.00 13.81 C

ATOM 6163 CDl ILE C 46 18.642 -8.087 48.320 1.00 13.64 C

ATOM 6164 CG2 ILE C 46 20.294 -10.593 47.243 1.00 14.60 C

ATOM 6165 C ILE C 46 19.964 -10.998 44.370 1.00 14.99 C

ATOM 6166 O ILE C 46 20.713 -10.249 43.738 1.00 14.75 O

ATOM 6167 N ASN C 47 20.088 -12.325 44.383 1.00 15.36 N

ATOM 6168 CA ASN C 47 21.265 -13.022 43.875 1.00 15.89 C

ATOM 6169 CB ASN C 47 20.954 -14.519 43.711 1.00 15.92 C

ATOM 6170 CG ASN C 47 22.083 -15.305 43.044 1.00 16.86 C

ATOM 6171 ODl ASN C 47 23.239 -14.872 42.998 1.00 17.38 O

ATOM 6172 ND2 ASN C 47 21.743 -16.487 42.533 1.00 17.41 N

ATOM 6173 C ASN C 47 22.422 -12.819 44.858 1.00 16.12 C

ATOM 6174 O ASN C 47 22.349 -13.288 46.000 1.00 16.21 O

ATOM 6175 N PRO C 48 23.486 -12.107 44.427 1.00 16.27 N

ATOM 6176 CA PRO C 48 24.605 -11.765 45.323 1.00 16.54 C

ATOM 6177 CB PRO C 48 25.529 -10.915 44.440 1.00 16.50 C

ATOM 6178 CG PRO C 48 25.126 -11.207 43.035 1.00 16.53 C

ATOM 6179 CD PRO C 48 23.675 -11.564 43.068 1.00 16.38 C

ATOM 6180 C PRO C 48 25.368 -12.960 45.902 1.00 16.70 C

ATOM 6181 O PRO C 48 25.991 -12.833 46.960 1.00 17.05 O

ATOM 6182 N CYS C 49 25.300 -14.104 45.224 1.00 16.99 N

ATOM 6183 CA CYS C 49 26.041 -15.303 45.615 1.00 16.70 C

ATOM 6184 CB CYS C 49 26.488 -16.078 44.370 1.00 16.80 C

ATOM 6185 SG CYS C 49 27.932 -17.137 44.645 1.00 18.27 S

ATOM 6186 C CYS C 49 25.242 -16.228 46.538 1.00 16.40 C

ATOM 6187 O CYS C 49 25.782 -17.195 47.074 1.00 16.76 O

ATOM 6188 N LEU C 50 23.963 -15.920 46.726 1.00 15.63 N

ATOM 6189 CA LEU C 50 23.061 -16.775 47.491 1.00 15.05 C

ATOM 6190 CB LEU C 50 21.613 -16.330 47.275 1.00 15.00 C

ATOM 6191 CG LEU C 50 20.486 -17.299 47.630 1.00 15.47 C

ATOM 6192 CDl LEU C 50 20.563 -18.587 46.815 1.00 14.93 C

ATOM 6193 CD2 LEU C 50 19.151 -16.607 47.427 1.00 15.20 C

ATOM 6194 C LEU C 50 23.393 -16.825 48.985 1.00 14.50 C

ATOM 6195 O LEU C 50 23.548 -17.906 49.548 1.00 14.50 O

ATOM 6196 N CYS C 51 23.510 -15.656 49.614 1.00 13.76 N

ATOM 6197 CA CYS C 51 23.729 -15.567 51.059 1.00 13.24 C

ATOM 6198 CB CYS C 51 22.645 -14.692 51.699 1.00 13.30 C

ATOM 6199 SG CYS C 51 20.971 -15.034 51.105 1.00 12.56 S

ATOM 6200 C CYS C 51 25.120 -15.016 51.387 1.00 13.01 C

ATOM 6201 O CYS C 51 25.743 -14.359 50.551 1.00 12.53 O

ATOM 6202 N THR C 52 25.601 -15.292 52.602 1.00 12.66 N

ATOM 6203 CA THR C 52 26.885 -14.753 53.062 1.00 12.71 C

ATOM 6204 CB THR C 52 27.558 -15.658 54.128 1.00 12.77 C

ATOM 6205 OGl THR C 52 26.707 -15.773 55.277 1.00 13.22 O

ATOM 6206 CG2 THR C 52 27.840 -17.047 53.565 1.00 13.66 C

ATOM 6207 C THR C 52 26.719 -13.339 53.631 1.00 12.46 C

ATOM 6208 O THR C 52 27.611 -12.492 53.505 1.00 12.14 O

ATOM 6209 N HIS C 53 25.574 -13.109 54.267 1.00 12.12 N

ATOM 6210 CA HIS C 53 25.244 -11.826 54.862 1.00 12.02 C

ATOM 6211 CB HIS C 53 25.325 -11.898 56.391 1.00 12.42 C

ATOM 6212 CG HIS C 53 26.713 -12.098 56.924 1.00 13.87 C

ATOM 6213 NDl HIS C 53 27.495 -13.183 56.588 1.00 15.96 N

ATOM 6214 CEl HIS C 53 28.655 -13.101 57.216 1.00 15.70 C

ATOM 6215 NE2 HIS C 53 28.649 -12.011 57.959 1.00 14.54 N

ATOM 6216 CD2 HIS C 53 27.445 -11.367 57.797 1.00 15.08 C W2025-7029WO / AM102903-PCT

ATOM 6217 C HIS C 53 23.838 -11.418 54.440 1.00 11.60 C

ATOM 6218 O HIS C 53 22.932 -12.250 54.378 1.00 11.53 O

ATOM 6219 N LEU C 54 23.670 -10.134 54.152 1.00 11.08 N

ATOM 6220 CA LEU C 54 22.365 -9.577 53.818 1.00 10.72 C

ATOM 6221 CB LEU C 54 22.352 -9.035 52.383 1.00 10.70 C

ATOM 6222 CG LEU C 54 22.533 -9.997 51.202 1.00 10.96 C

ATOM 6223 CDl LEU C 54 22.700 -9.198 49.918 1.00 11.40 C

ATOM 6224 CD2 LEU C 54 21.370 -10.979 51.077 1.00 10.48 C

ATOM 6225 C LEU C 54 22.014 -8.470 54.800 1.00 10.27 C

ATOM 6226 O LEU C 54 22.831 -7.585 55.074 1.00 10.35 O

ATOM 6227 N ILE C 55 20.801 -8.528 55.340 1.00 9.71 N

ATOM 6228 CA ILE C 55 20.355 -7.537 56.314 1.00 9.17 C

ATOM 6229 CB ILE C 55 20.055 -8.170 57.710 1.00 9.26 C

ATOM 6230 CGl ILE C 55 21.277 -8.957 58.210 1.00 8.50 C

ATOM 6231 CDl ILE C 55 21.166 -9.508 59.626 1.00 8.90 C

ATOM 6232 CG2 ILE C 55 19.646 -7.087 58.713 1.00 8.94 C

ATOM 6233 C ILE C 55 19.169 -6.733 55.782 1.00 9.20 C

ATOM 6234 O ILE C 55 18.196 -7.297 55.270 1.00 9.06 O

ATOM 6235 N TYR C 56 19.284 -5.411 55.896 1.00 9.02 N

ATOM 6236 CA TYR C 56 18.284 -4.473 55.404 1.00 8.99 C

ATOM 6237 CB TYR C 56 18.986 -3.230 54.827 1.00 9.29 C

ATOM 6238 CG TYR C 56 18.107 -2.304 54.002 1.00 9.23 C

ATOM 6239 CDl TYR C 56 18.236 -2.248 52.611 1.00 9.33 C

ATOM 6240 CEl TYR C 56 17.441 -1.396 51.846 1.00 8.93 C

ATOM 6241 CZ TYR C 56 16.505 -0.592 52.474 1.00 9.42 C

ATOM 6242 OH TYR C 56 15.721 0.248 51.724 1.00 10.75 O

ATOM 6243 CE2 TYR C 56 16.356 -0.622 53.855 1.00 9.32 C

ATOM 6244 CD2 TYR C 56 17.164 -1.471 54.611 1.00 8.95 C

ATOM 6245 C TYR C 56 17.323 -4.088 56.533 1.00 8.78 C

ATOM 6246 O TYR C 56 17.739 -3.512 57.538 1.00 8.48 O

ATOM 6247 N ALA C 57 16.044 -4.421 56.351 1.00 8.54 N

ATOM 6248 CA ALA C 57 14.977 -4.114 57.313 1.00 8.35 C

ATOM 6249 CB ALA C 57 14.255 -5.402 57.708 1.00 8.35 C

ATOM 6250 C ALA C 57 13.979 -3.115 56.711 1.00 8.18 C

ATOM 6251 O ALA C 57 13.491 -3.347 55.602 1.00 8.13 O

ATOM 6252 N PHE C 58 13.664 -2.010 57.399 1.00 7.90 N

ATOM 6253 CA PHE C 58 14.241 -1.601 58.686 1.00 7.56 C

ATOM 6254 CB PHE C 58 13.205 -1.728 59.818 1.00 7.39 C

ATOM 6255 CG PHE C 58 12.899 -3.151 60.227 1.00 6.85 C

ATOM 6256 CDl PHE C 58 11.655 -3.711 59.949 1.00 6.34 C

ATOM 6257 CEl PHE C 58 11.366 -5.020 60.314 1.00 6.46 C

ATOM 6258 CZ PHE C 58 12.330 -5.785 60.978 1.00 6.59 C

ATOM 6259 CE2 PHE C 58 13.572 -5.237 61.265 1.00 5.27 C

ATOM 6260 CD2 PHE C 58 13.851 -3.922 60.894 1.00 6.03 C

ATOM 6261 C PHE C 58 14.657 -0.130 58.617 1.00 7.73 C

ATOM 6262 O PHE C 58 14.135 0.626 57.796 1.00 7.68 O

ATOM 6263 N ALA C 59 15.586 0.265 59.489 1.00 7.64 N

ATOM 6264 CA ALA C 59 15.838 1.676 59.790 1.00 7.76 C

ATOM 6265 CB ALA C 59 17.318 1.905 60.078 1.00 7.77 C

ATOM 6266 C ALA C 59 14.996 2.111 60.987 1.00 7.88 C

ATOM 6267 O ALA C 59 14.488 1.270 61.742 1.00 8.29 O

ATOM 6268 N GLY C 60 14.849 3.422 61.166 1.00 8.06 N

ATOM 6269 CA GLY C 60 14.078 3.970 62.279 1.00 8.54 C

ATOM 6270 C GLY C 60 14.928 4.762 63.252 1.00 8.82 C

ATOM 6271 O GLY C 60 16.152 4.601 63.294 1.00 9.03 O

ATOM 6272 N MET C 61 14.276 5.617 64.036 1.00 9.07 N

ATOM 6273 CA MET C 61 14.975 6.459 65.009 1.00 9.48 C

ATOM 6274 CB MET C 61 15.157 5.713 66.340 1.00 9.45 C

ATOM 6275 CG MET C 61 16.263 6.275 67.232 1.00 9.66 C

ATOM 6276 SD MET C 61 16.204 5.730 68.957 1.00 10.57 S

ATOM 6277 CE MET C 61 16.365 3.957 68.768 1.00 9.56 C

ATOM 6278 C MET C 61 14.245 7.782 65.240 1.00 9.22 C

ATOM 6279 O MET C 61 13.021 7.814 65.357 1.00 9.32 O W2025-7029WO / AM102903-PCT

ATOM 6280 N GLN C 62 15.017 8.864 65.302 1.00 9.07 N

ATOM 6281 CA GLN C 62 14.526 10.200 65.640 1.00 9.09 C

ATOM 6282 CB GLN C 62 14.249 11.009 64.382 1.00 8.94 C

ATOM 6283 CG GLN C 62 13.036 10.594 63.579 1.00 8.99 C

ATOM 6284 CD GLN C 62 12.871 11.445 62.341 1.00 8.80 C

ATOM 6285 OEl GLN C 62 13.050 12.661 62.388 1.00 8.29 O

ATOM 6286 NE2 GLN C 62 12.529 10.813 61.224 1.00 8.81 N

ATOM 6287 C GLN C 62 15.613 10.915 66.422 1.00 9.37 C

ATOM 6288 O GLN C 62 16.789 10.835 66.058 1.00 9.23 O

ATOM 6289 N ASN C 63 15.229 11.616 67.484 1.00 9.54 N

ATOM 6290 CA ASN C 63 16.186 12.360 68.311 1.00 10.18 C

ATOM 6291 CB ASN C 63 16.690 13.614 67.563 1.00 10.21 C

ATOM 6292 CG ASN C 63 15.560 14.409 66.916 1.00 10.91 C

ATOM 6293 ODl ASN C 63 14.694 14.948 67.600 1.00 12.84 O

ATOM 6294 ND2 ASN C 63 15.570 14.483 65.591 1.00 11.22 N

ATOM 6295 C ASN C 63 17.358 11.488 68.779 1.00 10.06 C

ATOM 6296 O ASN C 63 18.503 11.946 68.833 1.00 10.20 O

ATOM 6297 N ASN C 64 17.054 10.232 69.114 1.00 10.28 N

ATOM 6298 CA ASN C 64 18.056 9.231 69.523 1.00 10.29 C

ATOM 6299 CB ASN C 64 18.711 9.621 70.857 1.00 10.11 C

ATOM 6300 CG ASN C 64 17.707 9.701 71.991 1.00 10.04 C

ATOM 6301 ODl ASN C 64 17.036 8.720 72.303 1.00 8.70 O

ATOM 6302 ND2 ASN C 64 17.589 10.876 72.603 1.00 8.59 N

ATOM 6303 C ASN C 64 19.112 8.943 68.453 1.00 10.40 C

ATOM 6304 O ASN C 64 20.257 8.617 68.763 1.00 10.52 O

ATOM 6305 N GLU C 65 18.711 9.072 67.192 1.00 10.43 N

ATOM 6306 CA GLU C 65 19.607 8.864 66.061 1.00 10.63 C

ATOM 6307 CB GLU C 65 19.993 10.207 65.425 1.00 10.23 C

ATOM 6308 CG GLU C 65 20.713 11.154 66.380 1.00 10.65 C

ATOM 6309 CD GLU C 65 21.124 12.485 65.756 1.00 11.10 C

ATOM 6310 OEl GLU C 65 22.184 13.005 66.160 1.00 12.29 O

ATOM 6311 OE2 GLU C 65 20.402 13.016 64.875 1.00 11.27 O

ATOM 6312 C GLU C 65 18.950 7.956 65.028 1.00 10.65 C

ATOM 6313 O GLU C 65 17.734 8.016 64.819 1.00 10.46 O

ATOM 6314 N ILE C 66 19.757 7.121 64.380 1.00 10.54 N

ATOM 6315 CA ILE C 66 19.251 6.224 63.346 1.00 10.91 C

ATOM 6316 CB ILE C 66 20.299 5.119 62.980 1.00 11.09 C

ATOM 6317 CGl ILE C 66 19.649 3.975 62.184 1.00 10.75 C

ATOM 6318 CDl ILE C 66 20.514 2.734 62.057 1.00 10.63 C

ATOM 6319 CG2 ILE C 66 21.522 5.720 62.280 1.00 10.67 C

ATOM 6320 C ILE C 66 18.794 7.029 62.122 1.00 11.04 C

ATOM 6321 O ILE C 66 19.413 8.035 61.770 1.00 11.22 O

ATOM 6322 N THR C 67 17.692 6.602 61.507 1.00 11.31 N

ATOM 6323 CA THR C 67 17.125 7.285 60.333 1.00 11.52 C

ATOM 6324 CB THR C 67 15.966 8.260 60.720 1.00 11.63 C

ATOM 6325 OGl THR C 67 14.860 7.516 61.245 1.00 12.82 O

ATOM 6326 CG2 THR C 67 16.401 9.286 61.753 1.00 11.49 C

ATOM 6327 C THR C 67 16.556 6.281 59.334 1.00 11.46 C

ATOM 6328 O THR C 67 16.302 5.128 59.678 1.00 11.40 O

ATOM 6329 N THR C 68 16.336 6.732 58.100 1.00 11.46 N

ATOM 6330 CA THR C 68 15.547 5.975 57.123 1.00 11.59 C

ATOM 6331 CB THR C 68 15.634 6.614 55.732 1.00 11.54 C

ATOM 6332 OGl THR C 68 15.090 7.937 55.791 1.00 12.04 O

ATOM 6333 CG2 THR C 68 17.086 6.682 55.245 1.00 10.68 C

ATOM 6334 C THR C 68 14.075 5.962 57.540 1.00 11.85 C

ATOM 6335 O THR C 68 13.666 6.744 58.409 1.00 12.04 O

ATOM 6336 N ILE C 69 13.281 5.081 56.928 1.00 11.92 N

ATOM 6337 CA ILE C 69 11.823 5.085 57.134 1.00 12.23 C

ATOM 6338 CB ILE C 69 11.309 3.899 58.004 1.00 11.98 C

ATOM 6339 CGl ILE C 69 11.595 2.549 57.336 1.00 12.22 C

ATOM 6340 CDl ILE C 69 10.827 1.370 57.954 1.00 12.78 C

ATOM 6341 CG2 ILE C 69 11.853 3.988 59.434 1.00 12.57 C

ATOM 6342 C ILE C 69 11.006 5.162 55.839 1.00 12.15 C W2025-7029WO / AM102903-PCT

ATOM 6343 O ILE C 69 -9.867 5.611 55.862 1.00 12.26 O

ATOM 6344 N GLU C 70 11.586 4.715 54.726 1.00 12.17 N

ATOM 6345 CA GLU C 70 10.960 4.857 53.409 1.00 12.18 C

ATOM 6346 CB GLU C 70 11.052 3.548 52.617 1.00 12.40 C

ATOM 6347 CG GLU C 70 10.127 2.440 53.129 1.00 12.92 C

ATOM 6348 CD GLU C 70 -8.651 2.780 52.986 1.00 15.17 C

ATOM 6349 OEl GLU C 70 -7.849 2.294 53.812 1.00 15.61 O

ATOM 6350 OE2 GLU C 70 -8.289 3.541 52.056 1.00 16.69 O

ATOM 6351 C GLU C 70 11.575 6.010 52.612 1.00 12.01 C

ATOM 6352 O GLU C 70 12.782 6.241 52.681 1.00 11.82 O

ATOM 6353 N TRP C 71 10.737 6.718 51.853 1.00 11.62 N

ATOM 6354 CA TRP C 71 11.150 7.904 51.093 1.00 11.69 C

ATOM 6355 CB TRP C 71 -9.959 8.493 50.313 1.00 11.84 C

ATOM 6356 CG TRP C 71 -9.494 7.604 49.190 1.00 12.18 C

ATOM 6357 CDl TRP C 71 -8.714 6.487 49.299 1.00 12.43 C

ATOM 6358 NEl TRP C 71 -8.515 5.927 48.059 1.00 13.02 N

ATOM 6359 CE2 TRP C 71 -9.168 6.678 47.117 1.00 12.33 C

ATOM 6360 CD2 TRP C 71 -9.802 7.744 47.792 1.00 12.63 C

ATOM 6361 CE3 TRP C 71 10.548 8.671 47.046 1.00 12.48 C

ATOM 6362 CZ3 TRP C 71 10.633 8.503 45.660 1.00 12.61 C

ATOM 6363 CH2 TRP C 71 -9.991 7.428 45.019 1.00 12.23 C

ATOM 6364 CZ2 TRP C 71 -9.254 6.510 45.726 1.00 12.52 C

ATOM 6365 C TRP C 71 12.326 7.657 50.138 1.00 11.47 C

ATOM 6366 O TRP C 71 13.112 8.570 49.878 1.00 11.38 O

ATOM 6367 N ASN C 72 12.437 6.433 49.620 1.00 11.29 N

ATOM 6368 CA ASN C 72 13.498 6.079 48.670 1.00 11.16 C

ATOM 6369 CB ASN C 72 12.895 5.499 47.376 1.00 11.32 C

ATOM 6370 CG ASN C 72 12.079 4.231 47.614 1.00 11.84 C

ATOM 6371 ODl ASN C 72 11.700 3.917 48.743 1.00 12.84 O

ATOM 6372 ND2 ASN C 72 11.801 3.499 46.538 1.00 11.63 N

ATOM 6373 C ASN C 72 14.588 5.150 49.234 1.00 10.80 C

ATOM 6374 O ASN C 72 15.311 4.506 48.471 1.00 10.48 O

ATOM 6375 N ASP C 73 14.708 5.102 50.565 1.00 10.61 N

ATOM 6376 CA ASP C 73 15.678 4.221 51.242 1.00 10.32 C

ATOM 6377 CB ASP C 73 15.564 4.338 52.768 1.00 10.19 C

ATOM 6378 CG ASP C 73 14.623 3.301 53.382 1.00 9.60 C

ATOM 6379 ODl ASP C 73 14.351 2.262 52.744 1.00 8.89 O

ATOM 6380 OD2 ASP C 73 14.172 3.521 54.529 1.00 10.14 O

ATOM 6381 C ASP C 73 17.125 4.467 50.809 1.00 10.40 C

ATOM 6382 O ASP C 73 17.894 3.519 50.648 1.00 10.41 O

ATOM 6383 N VAL C 74 17.488 5.737 50.617 1.00 10.44 N

ATOM 6384 CA VAL C 74 18.845 6.090 50.187 1.00 10.41 C

ATOM 6385 CB VAL C 74 19.085 7.630 50.207 1.00 10.59 C

ATOM 6386 CGl VAL C 74 20.427 8.000 49.552 1.00 10.62 C

ATOM 6387 CG2 VAL C 74 19.041 8.152 51.638 1.00 10.10 C

ATOM 6388 C VAL C 74 19.169 5.458 48.822 1.00 10.32 C

ATOM 6389 O VAL C 74 20.252 4.906 48.637 1.00 9.91 O

ATOM 6390 N THR C 75 18.219 5.509 47.887 1.00 10.31 N

ATOM 6391 CA THR C 75 18.388 4.846 46.592 1.00 10.48 C

ATOM 6392 CB THR C 75 17.228 5.174 45.608 1.00 10.71 C

ATOM 6393 OGl THR C 75 17.119 6.594 45.448 1.00 10.56 O

ATOM 6394 CG2 THR C 75 17.474 4.534 44.234 1.00 10.73 C

ATOM 6395 C THR C 75 18.536 3.329 46.770 1.00 10.51 C

ATOM 6396 O THR C 75 19.422 2.708 46.172 1.00 10.53 O

ATOM 6397 N LEU C 76 17.682 2.748 47.611 1.00 10.50 N

ATOM 6398 CA LEU C 76 17.708 1.312 47.876 1.00 10.47 C

ATOM 6399 CB LEU C 76 16.455 0.864 48.643 1.00 10.48 C

ATOM 6400 CG LEU C 76 15.082 1.153 48.010 1.00 10.92 C

ATOM 6401 CDl LEU C 76 13.941 0.598 48.863 1.00 11.57 C

ATOM 6402 CD2 LEU C 76 14.979 0.617 46.590 1.00 11.43 C

ATOM 6403 C LEU C 76 18.993 0.852 48.579 1.00 10.26 C

ATOM 6404 O LEU C 76 19.523 -0.204 48.237 1.00 10.14 O

ATOM 6405 N TYR C 77 19.489 1.644 49.535 1.00 10.08 N W2025-7029WO / AM102903-PCT

ATOM 6406 CA TYR C 77 20.747 1.338 50.233 1.00 10.17 C

ATOM 6407 CB TYR C 77 21.160 2.457 51.197 1.00 9.81 C

ATOM 6408 CG TYR C 77 20.330 2.664 52.448 1.00 9.74 C

ATOM 6409 CDl TYR C 77 19.452 1.686 52.928 1.00 9.53 C

ATOM 6410 CEl TYR C 77 18.711 1.905 54.097 1.00 8.92 C

ATOM 6411 CZ TYR C 77 18.867 3.102 54.793 1.00 8.99 C

ATOM 6412 OH TYR C 77 18.156 3.347 55.947 1.00 8.67 O

ATOM 6413 CE2 TYR C 77 19.742 4.069 54.339 1.00 8.80 C

ATOM 6414 CD2 TYR C 77 20.469 3.844 53.183 1.00 9.11 C

ATOM 6415 C TYR C 77 21.889 1.169 49.244 1.00 10.67 C

ATOM 6416 O TYR C 77 22.712 0.266 49.382 1.00 10.75 O

ATOM 6417 N GLN C 78 21.938 2.072 48.266 1.00 11.12 N

ATOM 6418 CA GLN C 78 22.993 2.103 47.263 1.00 12.08 C

ATOM 6419 CB GLN C 78 22.887 3.382 46.417 1.00 11.96 C

ATOM 6420 CG GLN C 78 24.088 3.631 45.507 1.00 13.85 C

ATOM 6421 CD GLN C 78 23.964 4.905 44.689 1.00 14.14 C

ATOM 6422 OEl GLN C 78 22.869 5.456 44.522 1.00 18.50 O

ATOM 6423 NE2 GLN C 78 25.091 5.381 44.170 1.00 16.95 N

ATOM 6424 C GLN C 78 22.973 0.853 46.380 1.00 11.37 C

ATOM 6425 O GLN C 78 24.018 0.253 46.142 1.00 11.24 O

ATOM 6426 N ALA C 79 21.786 0.466 45.905 1.00 10.98 N

ATOM 6427 CA ALA C 79 21.622 -0.779 45.151 1.00 10.54 C

ATOM 6428 CB ALA C 79 20.214 -0.871 44.562 1.00 10.92 C

ATOM 6429 C ALA C 79 21.930 -2.009 46.020 1.00 10.34 C

ATOM 6430 O ALA C 79 22.641 -2.920 45.585 1.00 9.85 O

ATOM 6431 N PHE C 80 21.397 -2.015 47.244 1.00 9.90 N

ATOM 6432 CA PHE C 80 21.631 -3.088 48.218 1.00 9.75 C

ATOM 6433 CB PHE C 80 20.933 -2.752 49.544 1.00 9.62 C

ATOM 6434 CG PHE C 80 20.884 -3.897 50.528 1.00 9.32 C

ATOM 6435 CDl PHE C 80 21.675 -3.877 51.675 1.00 8.97 C

ATOM 6436 CEl PHE C 80 21.626 -4.915 52.592 1.00 8.02 C

ATOM 6437 CZ PHE C 80 20.777 -5.981 52.377 1.00 9.09 C

ATOM 6438 CE2 PHE C 80 19.973 -6.014 51.236 1.00 9.00 C

ATOM 6439 CD2 PHE C 80 20.029 -4.973 50.327 1.00 8.83 C

ATOM 6440 C PHE C 80 23.119 -3.317 48.462 1.00 9.67 C

ATOM 6441 O PHE C 80 23.620 -4.435 48.316 1.00 9.85 O

ATOM 6442 N ASN C 81 23.825 -2.254 48.828 1.00 9.67 N

ATOM 6443 CA ASN C 81 25.245 -2.358 49.133 1.00 9.65 C

ATOM 6444 CB ASN C 81 25.676 -1.191 50.016 1.00 9.69 C

ATOM 6445 CG ASN C 81 25.111 -1.299 51.420 1.00 9.65 C

ATOM 6446 ODl ASN C 81 25.057 -2.389 51.990 1.00 8.43 O

ATOM 6447 ND2 ASN C 81 24.689 -0.176 51.983 1.00 8.89 N

ATOM 6448 C ASN C 81 26.113 -2.494 47.883 1.00 9.82 C

ATOM 6449 O ASN C 81 27.245 -2.993 47.947 1.00 9.52 O

ATOM 6450 N GLY C 82 25.554 -2.081 46.747 1.00 10.05 N

ATOM 6451 CA GLY C 82 26.189 -2.251 45.446 1.00 10.51 C

ATOM 6452 C GLY C 82 26.306 -3.700 45.006 1.00 10.96 C

ATOM 6453 O GLY C 82 27.076 -4.005 44.091 1.00 10.89 O

ATOM 6454 N LEU C 83 25.545 -4.594 45.649 1.00 11.07 N

ATOM 6455 CA LEU C 83 25.636 -6.040 45.385 1.00 11.43 C

ATOM 6456 CB LEU C 83 24.529 -6.812 46.126 1.00 11.35 C

ATOM 6457 CG LEU C 83 23.054 -6.530 45.795 1.00 11.41 C

ATOM 6458 CDl LEU C 83 22.131 -7.093 46.874 1.00 11.43 C

ATOM 6459 CD2 LEU C 83 22.660 -7.063 44.416 1.00 12.20 C

ATOM 6460 C LEU C 83 27.014 -6.620 45.745 1.00 11.97 C

ATOM 6461 O LEU C 83 27.446 -7.616 45.155 1.00 11.59 O

ATOM 6462 N LYS C 84 27.693 -5.985 46.704 1.00 12.54 N

ATOM 6463 CA LYS C 84 29.044 -6.384 47.137 1.00 13.48 C

ATOM 6464 CB LYS C 84 29.453 -5.628 48.407 1.00 13.18 C

ATOM 6465 CG LYS C 84 28.619 -5.978 49.638 1.00 12.97 C

ATOM 6466 CD LYS C 84 29.159 -5.319 50.904 1.00 13.10 C

ATOM 6467 CE LYS C 84 28.683 -3.876 51.051 1.00 11.97 C

ATOM 6468 NZ LYS C 84 29.352 -3.198 52.199 1.00 12.47 N W2025-7029WO / AM102903-PCT

ATOM 6469 C LYS C 84 30.125 -6.209 46.059 1.00 14.47 C

ATOM 6470 O LYS C 84 31.257 -6.672 46.230 1.00 14.65 O

ATOM 6471 N ASN C 85 29.781 -5.532 44.965 1.00 15.27 N

ATOM 6472 CA ASN C 85 30.659 -5.451 43.795 1.00 16.42 C

ATOM 6473 CB ASN C 85 30.157 -4.392 42.808 1.00 16.59 C

ATOM 6474 CG ASN C 85 30.282 -2.967 43.342 1.00 17.35 C

ATOM 6475 ODl ASN C 85 31.083 -2.680 44.231 1.00 17.80 O

ATOM 6476 ND2 ASN C 85 29.486 -2.064 42.781 1.00 17.90 N

ATOM 6477 C ASN C 85 30.780 -6.800 43.081 1.00 16.89 C

ATOM 6478 O ASN C 85 31.753 -7.050 42.364 1.00 17.10 O

ATOM 6479 N LYS C 86 29.789 -7.662 43.301 1.00 17.26 N

ATOM 6480 CA LYS C 86 29.685 -8.958 42.633 1.00 17.88 C

ATOM 6481 CB LYS C 86 28.280 -9.119 42.028 1.00 17.79 C

ATOM 6482 CG LYS C 86 28.005 -8.148 40.877 1.00 18.35 C

ATOM 6483 CD LYS C 86 26.566 -8.210 40.389 1.00 18.81 C

ATOM 6484 CE LYS C 86 26.366 -7.286 39.195 1.00 20.83 C

ATOM 6485 NZ LYS C 86 24.931 -7.160 38.806 1.00 22.29 N

ATOM 6486 C LYS C 86 30.039 -10.152 43.534 1.00 17.87 C

ATOM 6487 O LYS C 86 30.227 -11.267 43.043 1.00 18.27 O

ATOM 6488 N ASN C 87 30.136 -9.912 44.842 1.00 17.94 N

ATOM 6489 CA ASN C 87 30.527 -10.944 45.809 1.00 17.92 C

ATOM 6490 CB ASN C 87 29.283 -11.498 46.527 1.00 18.07 C

ATOM 6491 CG ASN C 87 29.594 -12.665 47.466 1.00 17.94 C

ATOM 6492 ODl ASN C 87 30.751 -12.947 47.785 1.00 18.30 O

ATOM 6493 ND2 ASN C 87 28.545 -13.342 47.920 1.00 17.98 N

ATOM 6494 C ASN C 87 31.549 -10.400 46.811 1.00 17.88 C

ATOM 6495 O ASN C 87 31.212 -9.585 47.667 1.00 17.69 O

ATOM 6496 N SER C 88 32.788 -10.879 46.711 1.00 17.95 N

ATOM 6497 CA SER C 88 33.920 -10.297 47.451 1.00 18.18 C

ATOM 6498 CB SER C 88 35.253 -10.730 46.828 1.00 18.24 C

ATOM 6499 OG SER C 88 35.540 -12.087 47.113 1.00 18.94 O

ATOM 6500 C SER C 88 33.943 -10.556 48.961 1.00 17.98 C

ATOM 6501 O SER C 88 34.743 -9.957 49.682 1.00 18.52 O

ATOM 6502 N GLN C 89 33.090 -11.453 49.439 1.00 17.63 N

ATOM 6503 CA GLN C 89 33.043 -11.744 50.869 1.00 17.20 C

ATOM 6504 CB GLN C 89 33.399 -13.210 51.149 1.00 17.56 C

ATOM 6505 CG GLN C 89 34.756 -13.669 50.593 1.00 19.31 C

ATOM 6506 CD GLN C 89 35.958 -13.216 51.412 1.00 22.79 C

ATOM 6507 OEl GLN C 89 35.827 -12.713 52.536 1.00 23.63 O

ATOM 6508 NE2 GLN C 89 37.151 -13.410 50.849 1.00 24.12 N

ATOM 6509 C GLN C 89 31.689 -11.385 51.478 1.00 16.24 C

ATOM 6510 O GLN C 89 31.500 -11.514 52.683 1.00 16.23 O

ATOM 6511 N LEU C 90 30.766 -10.913 50.641 1.00 15.25 N

ATOM 6512 CA LEU C 90 29.429 -10.516 51.086 1.00 14.47 C

ATOM 6513 CB LEU C 90 28.544 -10.159 49.884 1.00 14.57 C

ATOM 6514 CG LEU C 90 27.120 -9.618 50.091 1.00 14.94 C

ATOM 6515 CDl LEU C 90 26.258 -10.575 50.899 1.00 15.17 C

ATOM 6516 CD2 LEU C 90 26.466 -9.312 48.742 1.00 14.53 C

ATOM 6517 C LEU C 90 29.489 -9.349 52.067 1.00 13.69 C

ATOM 6518 O LEU C 90 30.209 -8.377 51.850 1.00 13.40 O

ATOM 6519 N LYS C 91 28.742 -9.467 53.157 1.00 12.77 N

ATOM 6520 CA LYS C 91 28.650 -8.390 54.130 1.00 12.10 C

ATOM 6521 CB LYS C 91 29.312 -8.780 55.453 1.00 12.19 C

ATOM 6522 CG LYS C 91 30.833 -8.838 55.361 1.00 13.83 C

ATOM 6523 CD LYS C 91 31.454 -9.431 56.607 1.00 17.23 C

ATOM 6524 CE LYS C 91 32.952 -9.648 56.411 1.00 19.50 C

ATOM 6525 NZ LYS C 91 33.531 -10.500 57.488 1.00 21.52 N

ATOM 6526 C LYS C 91 27.201 -7.987 54.332 1.00 11.15 C

ATOM 6527 O LYS C 91 26.302 -8.833 54.343 1.00 10.86 O

ATOM 6528 N THR C 92 26.983 -6.685 54.466 1.00 10.13 N

ATOM 6529 CA THR C 92 25.644 -6.151 54.622 1.00 9.29 C

ATOM 6530 CB THR C 92 25.300 -5.134 53.523 1.00 9.52 C

ATOM 6531 OGl THR C 92 26.229 -4.037 53.571 1.00 8.35 O W2025-7029WO / AM102903-PCT

ATOM 6532 CG2 THR C 92 25.325 -5.800 52.139 1.00 9.25 C

ATOM 6533 C THR C 92 25.476 -5.491 55.976 1.00 9.06 C

ATOM 6534 O THR C 92 26.417 -4.910 56.527 1.00 8.63 O

ATOM 6535 N LEU C 93 24.266 -5.592 56.509 1.00 8.60 N

ATOM 6536 CA LEU C 93 23.932 -4.945 57.763 1.00 8.24 C

ATOM 6537 CB LEU C 93 23.899 -5.964 58.912 1.00 8.28 C

ATOM 6538 CG LEU C 93 25.204 -6.712 59.230 1.00 8.10 C

ATOM 6539 CDl LEU C 93 25.304 -8.008 58.426 1.00 8.17 C

ATOM 6540 CD2 LEU C 93 25.307 -7.016 60.716 1.00 7.59 C

ATOM 6541 C LEU C 93 22.609 -4.189 57.644 1.00 8.10 C

ATOM 6542 O LEU C 93 21.747 -4.541 56.833 1.00 7.85 O

ATOM 6543 N LEU C 94 22.474 -3.129 58.436 1.00 7.87 N

ATOM 6544 CA LEU C 94 21.208 -2.418 58.552 1.00 7.91 C

ATOM 6545 CB LEU C 94 21.434 -0.900 58.535 1.00 7.71 C

ATOM 6546 CG LEU C 94 20.227 0.044 58.556 1.00 7.76 C

ATOM 6547 CDl LEU C 94 19.288 -0.167 57.358 1.00 7.46 C

ATOM 6548 CD2 LEU C 94 20.708 1.485 58.591 1.00 8.00 C

ATOM 6549 C LEU C 94 20.524 -2.853 59.841 1.00 7.89 C

ATOM 6550 O LEU C 94 21.129 -2.812 60.916 1.00 7.83 O

ATOM 6551 N ALA C 95 19.275 -3.296 59.727 1.00 8.07 N

ATOM 6552 CA ALA C 95 18.497 -3.693 60.901 1.00 8.45 C

ATOM 6553 CB ALA C 95 17.609 -4.891 60.597 1.00 8.24 C

ATOM 6554 C ALA C 95 17.662 -2.515 61.390 1.00 8.73 C

ATOM 6555 O ALA C 95 16.950 -1.894 60.606 1.00 8.81 O

ATOM 6556 N ILE C 96 17.762 -2.214 62.683 1.00 8.68 N

ATOM 6557 CA ILE C 96 16.971 -1.141 63.286 1.00 8.82 C

ATOM 6558 CB ILE C 96 17.853 -0.144 64.106 1.00 8.82 C

ATOM 6559 CGl ILE C 96 17.002 1.026 64.632 1.00 8.86 C

ATOM 6560 CDl ILE C 96 17.799 2.222 65.108 1.00 8.15 C

ATOM 6561 CG2 ILE C 96 18.615 -0.856 65.242 1.00 8.72 C

ATOM 6562 C ILE C 96 15.817 -1.676 64.142 1.00 9.03 C

ATOM 6563 O ILE C 96 16.004 -2.578 64.965 1.00 9.07 O

ATOM 6564 N GLY C 97 14.627 -1.115 63.934 1.00 9.09 N

ATOM 6565 CA GLY C 97 13.479 -1.402 64.784 1.00 9.35 C

ATOM 6566 C GLY C 97 12.398 -2.169 64.055 1.00 9.76 C

ATOM 6567 O GLY C 97 11.825 -1.678 63.080 1.00 9.73 O

ATOM 6568 N GLY C 98 12.121 -3.378 64.534 1.00 9.98 N

ATOM 6569 CA GLY C 98 11.046 -4.193 63.985 1.00 10.29 C

ATOM 6570 C GLY C 98 -9.795 -4.161 64.839 1.00 10.55 C

ATOM 6571 O GLY C 98 -9.763 -3.518 65.895 1.00 10.66 O

ATOM 6572 N TRP C 99 -8.758 -4.849 64.366 1.00 10.69 N

ATOM 6573 CA TRP C 99 -7.525 -5.029 65.128 1.00 11.06 C

ATOM 6574 CB TRP C 99 -6.624 -6.075 64.463 1.00 10.92 C

ATOM 6575 CG TRP C 99 -5.570 -6.618 65.376 1.00 11.26 C

ATOM 6576 CDl TRP C 99 -4.227 -6.366 65.327 1.00 11.41 C

ATOM 6577 NEl TRP C 99 -3.580 -7.041 66.335 1.00 10.48 N

ATOM 6578 CE2 TRP C 99 -4.505 -7.753 67.055 1.00 11.52 C

ATOM 6579 CD2 TRP C 99 -5.771 -7.506 66.481 1.00 11.16 C

ATOM 6580 CE3 TRP C 99 -6.900 -8.121 67.041 1.00 11.81 C

ATOM 6581 CZ3 TRP C 99 -6.729 -8.951 68.148 1.00 11.35 C

ATOM 6582 CH2 TRP C 99 -5.454 -9.178 68.692 1.00 10.86 C

ATOM 6583 CZ2 TRP C 99 -4.335 -8.590 68.163 1.00 11.13 C

ATOM 6584 C TRP C 99 -6.757 -3.731 65.336 1.00 11.13 C

ATOM 6585 O TRP C 99 -6.476 -3.354 66.471 1.00 10.95 O

ATOM 6586 N ASN C 100 -6.430 -3.054 64.236 1.00 11.64 N

ATOM 6587 CA ASN C 100 -5.648 -1.820 64.266 1.00 12.16 C

ATOM 6588 CB ASN C 100 -5.382 -1.345 62.836 1.00 13.20 C

ATOM 6589 CG ASN C 100 -4.062 -0.638 62.697 1.00 16.05 C

ATOM 6590 ODl ASN C 100 -3.002 -1.271 62.726 1.00 20.97 O

ATOM 6591 ND2 ASN C 100 -4.108 0.683 62.525 1.00 19.46 N

ATOM 6592 C ASN C 100 -6.320 -0.697 65.064 1.00 11.67 C

ATOM 6593 O ASN C 100 -5.646 0.100 65.723 1.00 11.21 O

ATOM 6594 N PHE C 101 -7.649 -0.648 64.990 1.00 10.85 N W2025-7029WO / AM102903-PCT

ATOM 6595 CA PHE C 101 -8.468 0.334 65.712 1.00 10.45 C

ATOM 6596 CB PHE C 101 -9.950 0.035 65.446 1.00 10.23 C

ATOM 6597 CG PHE C 101 10.900 1.092 65.935 1.00 10.21 C

ATOM 6598 CDl PHE C 101 11.154 2.232 65.168 1.00 10.07 C

ATOM 6599 CEl PHE C 101 12.047 3.206 65.609 1.00 9.60 C

ATOM 6600 CZ PHE C 101 12.709 3.042 66.820 1.00 9.87 C

ATOM 6601 CE2 PHE C 101 12.472 1.904 67.590 1.00 10.30 C

ATOM 6602 CD2 PHE C 101 11.576 0.933 67.139 1.00 9.55 C

ATOM 6603 C PHE C 101 -8.185 0.355 67.219 1.00 10.31 C

ATOM 6604 O PHE C 101 -8.190 1.418 67.849 1.00 10.08 O

ATOM 6605 N GLY C 102 -7.947 -0.820 67.794 1.00 9.95 N

ATOM 6606 CA GLY C 102 -7.675 -0.928 69.226 1.00 9.92 C

ATOM 6607 C GLY C 102 -8.938 -0.766 70.051 1.00 9.71 C

ATOM 6608 O GLY C 102 10.042 -1.032 69.566 1.00 9.91 O

ATOM 6609 N THR C 103 -8.785 -0.298 71.288 1.00 9.24 N

ATOM 6610 CA THR C 103 -9.892 -0.312 72.255 1.00 8.85 C

ATOM 6611 CB THR C 103 -9.588 -1.257 73.434 1.00 8.57 C

ATOM 6612 OGl THR C 103 -8.441 -0.770 74.146 1.00 8.14 O

ATOM 6613 CG2 THR C 103 -9.327 -2.688 72.948 1.00 8.79 C

ATOM 6614 C THR C 103 10.250 1.059 72.846 1.00 8.56 C

ATOM 6615 O THR C 103 11.344 1.235 73.391 1.00 8.14 O

ATOM 6616 N ALA C 104 -9.323 2.010 72.752 1.00 8.25 N

ATOM 6617 CA ALA C 104 -9.480 3.318 73.403 1.00 8.13 C

ATOM 6618 CB ALA C 104 -8.228 4.178 73.216 1.00 8.11 C

ATOM 6619 C ALA C 104 10.749 4.093 73.017 1.00 8.17 C

ATOM 6620 O ALA C 104 11.436 4.602 73.908 1.00 8.34 O

ATOM 6621 N PRO C 105 11.071 4.191 71.705 1.00 8.00 N

ATOM 6622 CA PRO C 105 12.288 4.922 71.360 1.00 8.10 C

ATOM 6623 CB PRO C 105 12.251 4.975 69.826 1.00 8.22 C

ATOM 6624 CG PRO C 105 10.833 4.667 69.456 1.00 8.36 C

ATOM 6625 CD PRO C 105 10.388 3.699 70.494 1.00 8.15 C

ATOM 6626 C PRO C 105 13.558 4.215 71.827 1.00 7.98 C

ATOM 6627 O PRO C 105 14.536 4.883 72.152 1.00 7.81 O

ATOM 6628 N PHE C 106 13.537 2.881 71.855 1.00 8.14 N

ATOM 6629 CA PHE C 106 14.660 2.099 72.378 1.00 8.08 C

ATOM 6630 CB PHE C 106 14.462 0.602 72.133 1.00 7.89 C

ATOM 6631 CG PHE C 106 14.807 0.146 70.736 1.00 7.72 C

ATOM 6632 CDl PHE C 106 16.104 0.275 70.243 1.00 7.29 C

ATOM 6633 CEl PHE C 106 16.422 -0.153 68.962 1.00 7.30 C

ATOM 6634 CZ PHE C 106 15.445 -0.742 68.163 1.00 7.37 C

ATOM 6635 CE2 PHE C 106 14.153 -0.896 68.651 1.00 7.11 C

ATOM 6636 CD2 PHE C 106 13.839 -0.450 69.930 1.00 6.50 C

ATOM 6637 C PHE C 106 14.830 2.357 73.873 1.00 8.25 C

ATOM 6638 O PHE C 106 15.948 2.573 74.351 1.00 8.35 O

ATOM 6639 N THR C 107 13.716 2.329 74.606 1.00 8.36 N

ATOM 6640 CA THR C 107 13.726 2.627 76.033 1.00 8.22 C

ATOM 6641 CB THR C 107 12.331 2.460 76.659 1.00 8.29 C

ATOM 6642 OGl THR C 107 11.871 1.119 76.439 1.00 7.96 O

ATOM 6643 CG2 THR C 107 12.389 2.735 78.157 1.00 7.80 C

ATOM 6644 C THR C 107 14.282 4.031 76.315 1.00 8.32 C

ATOM 6645 O THR C 107 15.185 4.184 77.145 1.00 8.39 O

ATOM 6646 N ALA C 108 13.756 5.037 75.610 1.00 8.31 N

ATOM 6647 CA ALA C 108 14.244 6.418 75.721 1.00 8.32 C

ATOM 6648 CB ALA C 108 13.437 7.343 74.813 1.00 8.27 C

ATOM 6649 C ALA C 108 15.743 6.540 75.417 1.00 8.46 C

ATOM 6650 O ALA C 108 16.487 7.189 76.165 1.00 8.28 O

ATOM 6651 N MET C 109 16.181 5.898 74.332 1.00 8.63 N

ATOM 6652 CA MET C 109 17.585 5.953 73.902 1.00 8.88 C

ATOM 6653 CB MET C 109 17.738 5.366 72.491 1.00 8.72 C

ATOM 6654 CG MET C 109 19.140 5.465 71.901 1.00 9.10 C

ATOM 6655 SD MET C 109 20.193 4.049 72.295 1.00 9.95

ATOM 6656 CE MET C 109 19.387 2.767 71.325 1.00 7.91

ATOM 6657 C MET C 109 18.580 5.313 74.882 1.00 8.85 W2025-7029WO / AM102903-PCT

ATOM 6658 O MET C 109 19.672 5.849 75.098 1.00 9.03 O

ATOM 6659 N VAL C 110 18.216 4.178 75.473 1.00 9.00 N

ATOM 6660 CA VAL C 110 19.133 3.482 76.389 1.00 8.92 C

ATOM 6661 CB VAL C 110 18.925 1.930 76.393 1.00 9.11 C

ATOM 6662 CGl VAL C 110 19.074 1.359 74.989 1.00 8.71 C

ATOM 6663 CG2 VAL C 110 17.570 1.540 77.005 1.00 8.94 C

ATOM 6664 C VAL C 110 19.104 4.023 77.826 1.00 9.09 C

ATOM 6665 O VAL C 110 19.969 3.686 78.639 1.00 8.86 O

ATOM 6666 N SER C 111 18.120 4.870 78.120 1.00 9.27 N

ATOM 6667 CA SER C 111 17.893 5.372 79.479 1.00 9.68 C

ATOM 6668 CB SER C 111 16.562 6.134 79.567 1.00 9.55 C

ATOM 6669 OG SER C 111 16.569 7.293 78.756 1.00 8.72 O

ATOM 6670 C SER C 111 19.041 6.213 80.052 1.00 10.26 C

ATOM 6671 O SER C 111 19.219 6.256 81.277 1.00 10.38 O

ATOM 6672 N THR C 112 19.810 6.871 79.177 1.00 10.65 N

ATOM 6673 CA THR C 112 20.935 7.720 79.611 1.00 11.27 C

ATOM 6674 CB THR C 112 20.568 9.240 79.623 1.00 11.17 C

ATOM 6675 OGl THR C 112 20.373 9.709 78.287 1.00 10.56 O

ATOM 6676 CG2 THR C 112 19.304 9.510 80.438 1.00 11.32 C

ATOM 6677 C THR C 112 22.223 7.498 78.792 1.00 11.55 C

ATOM 6678 O THR C 112 22.160 7.137 77.615 1.00 11.63 O

ATOM 6679 N PRO C 113 23.397 7.689 79.425 1.00 11.86 N

ATOM 6680 CA PRO C 113 24.675 7.601 78.705 1.00 12.06 C

ATOM 6681 CB PRO C 113 25.715 7.979 79.769 1.00 11.91 C

ATOM 6682 CG PRO C 113 25.049 7.730 81.069 1.00 12.20 C

ATOM 6683 CD PRO C 113 23.590 7.952 80.865 1.00 11.82 C

ATOM 6684 C PRO C 113 24.768 8.547 77.503 1.00 12.15 C

ATOM 6685 O PRO C 113 25.313 8.163 76.472 1.00 12.20 O

ATOM 6686 N GLU C 114 24.232 9.761 77.642 1.00 12.33 N

ATOM 6687 CA GLU C 114 24.236 10.770 76.572 1.00 12.33 C

ATOM 6688 CB GLU C 114 23.704 12.117 77.081 1.00 12.53 C

ATOM 6689 CG GLU C 114 24.124 12.473 78.494 1.00 14.46 C

ATOM 6690 CD GLU C 114 23.114 12.040 79.552 1.00 15.53 C

ATOM 6691 OEl GLU C 114 21.942 12.497 79.514 1.00 15.96 O

ATOM 6692 OE2 GLU C 114 23.508 11.262 80.444 1.00 16.40 O

ATOM 6693 C GLU C 114 23.423 10.339 75.350 1.00 11.93 C

ATOM 6694 O GLU C 114 23.872 10.501 74.209 1.00 11.53 O

ATOM 6695 N ASN C 115 22.227 9.803 75.601 1.00 11.63 N

ATOM 6696 CA ASN C 115 21.355 9.292 74.543 1.00 11.34 C

ATOM 6697 CB ASN C 115 19.970 8.939 75.102 1.00 11.37 C

ATOM 6698 CG ASN C 115 19.173 10.165 75.527 1.00 11.93 C

ATOM 6699 ODl ASN C 115 19.650 11.299 75.445 1.00 12.00 O

ATOM 6700 ND2 ASN C 115 17.946 9.937 75.985 1.00 11.85 N

ATOM 6701 C ASN C 115 21.962 8.096 73.809 1.00 11.20 C

ATOM 6702 O ASN C 115 21.818 7.977 72.590 1.00 11.07 O

ATOM 6703 N ARG C 116 22.637 7.216 74.553 1.00 11.10 N

ATOM 6704 CA ARG C 116 23.345 6.087 73.943 1.00 11.02 C

ATOM 6705 CB ARG C 116 23.826 5.073 74.995 1.00 10.96 C

ATOM 6706 CG ARG C 116 22.685 4.357 75.733 1.00 10.47 C

ATOM 6707 CD ARG C 116 23.144 3.129 76.497 1.00 9.83 C

ATOM 6708 NE ARG C 116 24.192 3.421 77.479 1.00 8.65 N

ATOM 6709 CZ ARG C 116 23.983 3.779 78.744 1.00 7.84 C

ATOM 6710 NHl ARG C 116 22.748 3.913 79.225 1.00 6.30 N

ATOM 6711 NH2 ARG C 116 25.027 4.005 79.533 1.00 6.11 N

ATOM 6712 C ARG C 116 24.507 6.589 73.081 1.00 11.30 C

ATOM 6713 O ARG C 116 24.691 6.118 71.961 1.00 11.26 O

ATOM 6714 N GLN C 117 25.260 7.559 73.599 1.00 11.73 N

ATOM 6715 CA GLN C 117 26.375 8.172 72.864 1.00 12.59 C

ATOM 6716 CB GLN C 117 27.154 9.138 73.771 1.00 12.90 C

ATOM 6717 CG GLN C 117 28.300 9.859 73.072 1.00 15.91 C

ATOM 6718 CD GLN C 117 29.414 8.916 72.641 1.00 19.29 C

ATOM 6719 OEl GLN C 117 30.228 8.483 73.461 1.00 20.88 O

ATOM 6720 NE2 GLN C 117 29.457 8.595 71.348 1.00 20.86 N W2025-7029WO / AM102903-PCT

ATOM 6721 C GLN C 117 25.922 8.877 71.576 1.00 12.21 C

ATOM 6722 O GLN C 117 26.570 8.764 70.525 1.00 12.27 O

ATOM 6723 N THR C 118 24.810 9.603 71.669 1.00 11.95 N

ATOM 6724 CA THR C 118 24.188 10.249 70.516 1.00 11.32 C

ATOM 6725 CB THR C 118 22.936 11.052 70.937 1.00 11.30 C

ATOM 6726 OGl THR C 118 23.324 12.133 71.796 1.00 10.92 O

ATOM 6727 CG2 THR C 118 22.197 11.612 69.721 1.00 10.60 C

ATOM 6728 C THR C 118 23.804 9.207 69.463 1.00 11.23 C

ATOM 6729 O THR C 118 24.018 9.417 68.267 1.00 11.16 O

ATOM 6730 N PHE C 119 23.238 8.089 69.919 1.00 10.90 N

ATOM 6731 CA PHE C 119 22.855 6.994 69.026 1.00 10.77 C

ATOM 6732 CB PHE C 119 22.050 5.928 69.774 1.00 10.51 C

ATOM 6733 CG PHE C 119 21.523 4.838 68.887 1.00 11.05 C

ATOM 6734 CDl PHE C 119 20.463 5.082 68.015 1.00 10.82 C

ATOM 6735 CEl PHE C 119 19.984 4.081 67.188 1.00 10.95 C

ATOM 6736 CZ PHE C 119 20.557 2.809 67.230 1.00 10.91 C

ATOM 6737 CE2 PHE C 119 21.612 2.553 68.099 1.00 10.62 C

ATOM 6738 CD2 PHE C 119 22.089 3.564 68.919 1.00 10.60 C

ATOM 6739 C PHE C 119 24.053 6.361 68.320 1.00 10.54 C

ATOM 6740 O PHE C 119 24.062 6.255 67.095 1.00 10.76 O

ATOM 6741 N ILE C 120 25.054 5.957 69.097 1.00 10.34 N

ATOM 6742 CA ILE C 120 26.239 5.268 68.575 1.00 10.07 C

ATOM 6743 CB ILE C 120 27.157 4.778 69.727 1.00 10.14 C

ATOM 6744 CGl ILE C 120 26.405 3.754 70.590 1.00 10.13 C

ATOM 6745 CDl ILE C 120 27.005 3.509 71.979 1.00 9.94 C

ATOM 6746 CG2 ILE C 120 28.445 4.167 69.173 1.00 10.09 C

ATOM 6747 C ILE C 120 27.008 6.135 67.563 1.00 10.14 C

ATOM 6748 O ILE C 120 27.399 5.652 66.493 1.00 9.73 O

ATOM 6749 N THR C 121 27.196 7.411 67.903 1.00 10.01 N

ATOM 6750 CA THR C 121 27.775 8.397 66.987 1.00 10.28 C

ATOM 6751 CB THR C 121 27.796 9.804 67.630 1.00 10.21 C

ATOM 6752 OGl THR C 121 28.748 9.818 68.704 1.00 11.23 O

ATOM 6753 CG2 THR C 121 28.171 10.886 66.609 1.00 11.34 C

ATOM 6754 C THR C 121 27.026 8.414 65.647 1.00 9.96 C

ATOM 6755 O THR C 121 27.647 8.307 64.581 1.00 9.95 O

ATOM 6756 N SER C 122 25.696 8.513 65.710 1.00 9.66 N

ATOM 6757 CA SER C 122 24.856 8.531 64.507 1.00 9.39 C

ATOM 6758 CB SER C 122 23.391 8.855 64.852 1.00 9.27 C

ATOM 6759 OG SER C 122 22.678 7.723 65.330 1.00 8.73 O

ATOM 6760 C SER C 122 24.946 7.236 63.703 1.00 9.45 C

ATOM 6761 O SER C 122 24.965 7.273 62.467 1.00 9.60 O

ATOM 6762 N VAL C 123 24.993 6.101 64.404 1.00 9.34 N

ATOM 6763 CA VAL C 123 25.103 4.781 63.760 1.00 8.87 C

ATOM 6764 CB VAL C 123 24.937 3.621 64.778 1.00 8.98 C

ATOM 6765 CGl VAL C 123 25.288 2.280 64.149 1.00 8.31 C

ATOM 6766 CG2 VAL C 123 23.509 3.593 65.305 1.00 8.21 C

ATOM 6767 C VAL C 123 26.406 4.631 62.971 1.00 9.01 C

ATOM 6768 O VAL C 123 26.381 4.245 61.794 1.00 8.73 O

ATOM 6769 N ILE C 124 27.535 4.935 63.612 1.00 8.86 N

ATOM 6770 CA ILE C 124 28.831 4.896 62.933 1.00 9.43 C

ATOM 6771 CB ILE C 124 29.992 5.346 63.861 1.00 9.29 C

ATOM 6772 CGl ILE C 124 30.214 4.302 64.965 1.00 9.62 C

ATOM 6773 CDl ILE C 124 31.155 4.733 66.098 1.00 9.68 C

ATOM 6774 CG2 ILE C 124 31.281 5.552 63.048 1.00 9.62 C

ATOM 6775 C ILE C 124 28.801 5.721 61.633 1.00 9.61 C

ATOM 6776 O ILE C 124 29.157 5.213 60.563 1.00 9.56 O

ATOM 6777 N LYS C 125 28.351 6.971 61.729 1.00 9.83 N

ATOM 6778 CA LYS C 125 28.280 7.879 60.574 1.00 10.59 C

ATOM 6779 CB LYS C 125 27.827 9.270 61.027 1.00 10.78 C

ATOM 6780 CG LYS C 125 27.774 10.331 59.930 1.00 12.28 C

ATOM 6781 CD LYS C 125 27.536 11.703 60.539 1.00 15.99 C

ATOM 6782 CE LYS C 125 27.502 12.801 59.483 1.00 17.94 C

ATOM 6783 NZ LYS C 125 27.380 14.148 60.121 1.00 20.02 N W2025-7029WO / AM102903-PCT

ATOM 6784 C LYS C 125 27.364 7.360 59.460 1.00 10.58 C

ATOM 6785 O LYS C 125 27.702 7.441 58.274 1.00 10.73 O

ATOM 6786 N PHE C 126 26.217 6.822 59.858 1.00 10.46 N

ATOM 6787 CA PHE C 126 25.182 6.360 58.933 1.00 10.70 C

ATOM 6788 CB PHE C 126 23.928 6.021 59.743 1.00 10.79 C

ATOM 6789 CG PHE C 126 22.643 6.029 58.956 1.00 11.42 C

ATOM 6790 CDl PHE C 126 22.198 4.880 58.306 1.00 11.39 C

ATOM 6791 CEl PHE C 126 20.989 4.879 57.601 1.00 11.43 C

ATOM 6792 CZ PHE C 126 20.204 6.028 57.566 1.00 11.28 C

ATOM 6793 CE2 PHE C 126 20.631 7.177 58.227 1.00 11.21 C

ATOM 6794 CD2 PHE C 126 21.840 7.169 58.924 1.00 11.28 C

ATOM 6795 C PHE C 126 25.682 5.139 58.158 1.00 10.61 C

ATOM 6796 O PHE C 126 25.613 5.102 56.926 1.00 10.47 O

ATOM 6797 N LEU C 127 26.216 4.156 58.884 1.00 10.69 N

ATOM 6798 CA LEU C 127 26.716 2.930 58.268 1.00 10.43 C

ATOM 6799 CB LEU C 127 27.114 1.891 59.329 1.00 10.42 C

ATOM 6800 CG LEU C 127 26.029 1.359 60.285 1.00 9.86 C

ATOM 6801 CDl LEU C 127 26.592 0.276 61.184 1.00 9.06 C

ATOM 6802 CD2 LEU C 127 24.778 0.847 59.556 1.00 10.24 C

ATOM 6803 C LEU C 127 27.863 3.204 57.293 1.00 10.72 C

ATOM 6804 O LEU C 127 27.906 2.614 56.205 1.00 10.23 O

ATOM 6805 N ARG C 128 28.773 4.105 57.670 1.00 10.72 N

ATOM 6806 CA ARG C 128 29.903 4.459 56.797 1.00 11.00 C

ATOM 6807 CB ARG C 128 31.000 5.219 57.564 1.00 10.78 C

ATOM 6808 CG ARG C 128 31.772 4.391 58.599 1.00 11.28 C

ATOM 6809 CD ARG C 128 32.366 3.096 58.027 1.00 11.48 C

ATOM 6810 NE ARG C 128 33.259 2.423 58.978 1.00 11.07 N

ATOM 6811 CZ ARG C 128 33.752 1.193 58.826 1.00 11.63 C

ATOM 6812 NHl ARG C 128 33.441 0.457 57.761 1.00 11.64 N

ATOM 6813 NH2 ARG C 128 34.563 0.690 59.749 1.00 11.40 N

ATOM 6814 C ARG C 128 29.467 5.253 55.565 1.00 11.09 C

ATOM 6815 O ARG C 128 29.957 5.004 54.455 1.00 11.35 O

ATOM 6816 N GLN C 129 28.549 6.199 55.765 1.00 11.05 N

ATOM 6817 CA GLN C 129 28.005 7.023 54.679 1.00 11.34 C

ATOM 6818 CB GLN C 129 26.968 8.017 55.219 1.00 11.30 C

ATOM 6819 CG GLN C 129 26.510 9.074 54.209 1.00 11.92 C

ATOM 6820 CD GLN C 129 25.402 9.989 54.733 1.00 12.19 C

ATOM 6821 OEl GLN C 129 25.276 10.229 55.942 1.00 13.53 O

ATOM 6822 NE2 GLN C 129 24.594 10.509 53.815 1.00 11.25 N

ATOM 6823 C GLN C 129 27.387 6.163 53.571 1.00 11.08 C

ATOM 6824 O GLN C 129 27.646 6.389 52.386 1.00 10.73 O

ATOM 6825 N TYR C 130 26.594 5.168 53.969 1.00 11.00 N

ATOM 6826 CA TYR C 130 25.828 4.359 53.016 1.00 11.06 C

ATOM 6827 CB TYR C 130 24.387 4.183 53.505 1.00 11.43 C

ATOM 6828 CG TYR C 130 23.656 5.492 53.680 1.00 11.48 C

ATOM 6829 CDl TYR C 130 23.383 6.319 52.583 1.00 12.14 C

ATOM 6830 CEl TYR C 130 22.713 7.534 52.743 1.00 12.36 C

ATOM 6831 CZ TYR C 130 22.299 7.923 54.010 1.00 12.32 C

ATOM 6832 OH TYR C 130 21.634 9.121 54.186 1.00 12.26 O

ATOM 6833 CE2 TYR C 130 22.559 7.118 55.108 1.00 11.84 C

ATOM 6834 CD2 TYR C 130 23.233 5.908 54.937 1.00 11.92 C

ATOM 6835 C TYR C 130 26.476 3.018 52.687 1.00 10.84 C

ATOM 6836 O TYR C 130 25.951 2.251 51.875 1.00 10.77 O

ATOM 6837 N GLU C 131 27.625 2.761 53.312 1.00 10.77 N

ATOM 6838 CA GLU C 131 28.461 1.577 53.051 1.00 11.15 C

ATOM 6839 CB GLU C 131 28.925 1.513 51.582 1.00 11.12 C

ATOM 6840 CG GLU C 131 29.798 2.697 51.153 1.00 12.59 C

ATOM 6841 CD GLU C 131 30.350 2.564 49.736 1.00 13.10 C

ATOM 6842 OEl GLU C 131 31.578 2.724 49.562 1.00 16.66 O

ATOM 6843 OE2 GLU C 131 29.567 2.304 48.795 1.00 16.61 O

ATOM 6844 C GLU C 131 27.851 0.249 53.529 1.00 10.35 C

ATOM 6845 O GLU C 131 27.889 -0.762 52.826 1.00 10.45 O

ATOM 6846 N PHE C 132 27.297 0.265 54.738 1.00 9.61 N W2025-7029WO / AM102903-PCT

ATOM 6847 CA PHE C 132 26.919 -0.964 55.423 1.00 9.13 C

ATOM 6848 CB PHE C 132 25.735 -0.726 56.360 1.00 8.69 C

ATOM 6849 CG PHE C 132 24.414 -0.591 55.654 1.00 8.37 C

ATOM 6850 CDl PHE C 132 23.717 -1.725 55.228 1.00 7.67 C

ATOM 6851 CEl PHE C 132 22.483 -1.608 54.579 1.00 7.89 C

ATOM 6852 CZ PHE C 132 21.935 -0.344 54.360 1.00 8.40 C

ATOM 6853 CE2 PHE C 132 22.625 0.798 54.789 1.00 7.76 C

ATOM 6854 CD2 PHE C 132 23.855 0.667 55.433 1.00 7.17 C

ATOM 6855 C PHE C 132 28.119 -1.474 56.222 1.00 8.91 C

ATOM 6856 O PHE C 132 28.989 -0.690 56.622 1.00 8.60 O

ATOM 6857 N ASP C 133 28.157 -2.783 56.452 1.00 8.68 N

ATOM 6858 CA ASP C 133 29.229 -3.406 57.235 1.00 8.65 C

ATOM 6859 CB ASP C 133 29.625 -4.747 56.609 1.00 8.82 C

ATOM 6860 CG ASP C 133 30.138 -4.589 55.194 1.00 9.32 C

ATOM 6861 ODl ASP C 133 31.196 -3.945 55.020 1.00 9.51 O

ATOM 6862 OD2 ASP C 133 29.475 -5.095 54.260 1.00 9.93 O

ATOM 6863 C ASP C 133 28.889 -3.586 58.717 1.00 8.39 C

ATOM 6864 O ASP C 133 29.740 -4.005 59.511 1.00 8.09 O

ATOM 6865 N GLY C 134 27.654 -3.266 59.095 1.00 8.31 N

ATOM 6866 CA GLY C 134 27.228 -3.456 60.479 1.00 8.13 C

ATOM 6867 C GLY C 134 25.791 -3.091 60.792 1.00 8.35 C

ATOM 6868 O GLY C 134 25.022 -2.699 59.904 1.00 8.02 O

ATOM 6869 N LEU C 135 25.450 -3.206 62.076 1.00 8.32 N

ATOM 6870 CA LEU C 135 24.107 -2.958 62.567 1.00 8.25 C

ATOM 6871 CB LEU C 135 24.101 -1.814 63.591 1.00 8.15 C

ATOM 6872 CG LEU C 135 22.732 -1.361 64.114 1.00 8.48 C

ATOM 6873 CDl LEU C 135 22.027 -0.439 63.118 1.00 7.56 C

ATOM 6874 CD2 LEU C 135 22.874 -0.667 65.454 1.00 8.77 C

ATOM 6875 C LEU C 135 23.516 -4.210 63.200 1.00 8.18 C

ATOM 6876 O LEU C 135 24.163 -4.873 64.013 1.00 8.26 O

ATOM 6877 N ASP C 136 22.275 -4.512 62.828 1.00 7.95 N

ATOM 6878 CA ASP C 136 21.505 -5.576 63.461 1.00 7.61 C

ATOM 6879 CB ASP C 136 20.928 -6.509 62.384 1.00 7.71 C

ATOM 6880 CG ASP C 136 20.223 -7.722 62.963 1.00 7.42 C

ATOM 6881 ODl ASP C 136 20.818 -8.449 63.790 1.00 7.18 O

ATOM 6882 OD2 ASP C 136 19.067 -7.957 62.570 1.00 7.56 O

ATOM 6883 C ASP C 136 20.393 -4.960 64.315 1.00 7.29 C

ATOM 6884 O ASP C 136 19.530 -4.250 63.799 1.00 6.86 O

ATOM 6885 N PHE C 137 20.422 -5.224 65.620 1.00 7.01 N

ATOM 6886 CA PHE C 137 19.371 -4.745 66.523 1.00 7.30 C

ATOM 6887 CB PHE C 137 19.852 -4.744 67.980 1.00 7.14 C

ATOM 6888 CG PHE C 137 20.725 -3.574 68.337 1.00 7.50 C

ATOM 6889 CDl PHE C 137 22.100 -3.744 68.521 1.00 7.83 C

ATOM 6890 CEl PHE C 137 22.916 -2.658 68.860 1.00 7.30 C

ATOM 6891 CZ PHE C 137 22.353 -1.393 69.025 1.00 7.03 C

ATOM 6892 CE2 PHE C 137 20.978 -1.215 68.845 1.00 7.61 C

ATOM 6893 CD2 PHE C 137 20.175 -2.304 68.505 1.00 7.50 C

ATOM 6894 C PHE C 137 18.114 -5.605 66.413 1.00 7.33 C

ATOM 6895 O PHE C 137 18.182 -6.817 66.576 1.00 7.22 O

ATOM 6896 N ASP C 138 16.974 -4.975 66.134 1.00 7.77 N

ATOM 6897 CA ASP C 138 15.689 -5.676 66.095 1.00 8.03 C

ATOM 6898 CB ASP C 138 15.113 -5.701 64.679 1.00 8.18 C

ATOM 6899 CG ASP C 138 15.921 -6.564 63.751 1.00 8.95 C

ATOM 6900 ODl ASP C 138 15.377 -7.563 63.241 1.00 11.06 O

ATOM 6901 OD2 ASP C 138 17.110 -6.251 63.547 1.00 10.54 O

ATOM 6902 C ASP C 138 14.689 -5.090 67.075 1.00 7.93 C

ATOM 6903 O ASP C 138 13.538 -4.811 66.725 1.00 7.73 O

ATOM 6904 N TRP C 139 15.150 -4.917 68.310 1.00 8.33 N

ATOM 6905 CA TRP C 139 14.315 -4.464 69.410 1.00 8.52 C

ATOM 6906 CB TRP C 139 15.213 -3.994 70.556 1.00 8.44 C

ATOM 6907 CG TRP C 139 14.513 -3.403 71.754 1.00 8.39 C

ATOM 6908 CDl TRP C 139 13.165 -3.410 72.030 1.00 8.19 C

ATOM 6909 NEl TRP C 139 12.925 -2.794 73.234 1.00 7.77 N W2025-7029WO / AM102903-PCT

ATOM 6910 CE2 TRP C 139 14.120 -2.389 73.771 1.00 7.69 C

ATOM 6911 CD2 TRP C 139 15.142 -2.759 72.868 1.00 8.45 C

ATOM 6912 CE3 TRP C 139 16.473 -2.444 73.184 1.00 8.22 C

ATOM 6913 CZ3 TRP C 139 16.735 -1.778 74.374 1.00 8.20 C

ATOM 6914 CH2 TRP C 139 15.697 -1.422 75.247 1.00 8.16 C

ATOM 6915 CZ2 TRP C 139 14.387 -1.717 74.964 1.00 8.40 C

ATOM 6916 C TRP C 139 13.430 -5.630 69.853 1.00 8.86 C

ATOM 6917 O TRP C 139 13.931 -6.648 70.345 1.00 8.92 O

ATOM 6918 N GLU C 140 12.119 -5.480 69.670 1.00 9.15 N

ATOM 6919 CA GLU C 140 11.166 -6.527 70.032 1.00 9.64 C

ATOM 6920 CB GLU C 140 10.414 -7.037 68.791 1.00 9.67 C

ATOM 6921 CG GLU C 140 11.305 -7.367 67.580 1.00 10.36 C

ATOM 6922 CD GLU C 140 10.542 -8.051 66.463 1.00 10.75 C

ATOM 6923 OEl GLU C 140 10.062 -9.188 66.685 1.00 12.66 O

ATOM 6924 OE2 GLU C 140 10.425 -7.461 65.363 1.00 11.76 O

ATOM 6925 C GLU C 140 10.172 -6.050 71.102 1.00 9.54 C

ATOM 6926 O GLU C 140 -9.113 -5.519 70.767 1.00 9.58 O

ATOM 6927 N TYR C 141 10.494 -6.226 72.385 1.00 9.48 N

ATOM 6928 CA TYR C 141 11.762 -6.791 72.856 1.00 9.72 C

ATOM 6929 CB TYR C 141 11.596 -8.260 73.282 1.00 9.52 C

ATOM 6930 CG TYR C 141 10.969 -9.172 72.251 1.00 9.79 C

ATOM 6931 CDl TYR C 141 -9.596 -9.420 72.261 1.00 9.84 C

ATOM 6932 CEl TYR C 141 -9.009 -10.253 71.324 1.00 8.95 C

ATOM 6933 C Z TYR C 141 -9.799 -10.867 70.365 1.00 9.78 C

ATOM 6934 OH TYR C 141 -9.215 -11.697 69.442 1.00 9.77 O

ATOM 6935 CE2 TYR C 141 11.171 -10.647 70.334 1.00 9.03 C

ATOM 6936 CD2 TYR C 141 11.748 -9.803 71.276 1.00 8.65 C

ATOM 6937 C TYR C 141 12.192 -5.964 74.063 1.00 9.68 C

ATOM 6938 O TYR C 141 11.383 -5.206 74.594 1.00 9.79 O

ATOM 6939 N PRO C 142 13.466 -6.075 74.489 1.00 10.01 N

ATOM 6940 CA PRO C 142 13.785 -5.507 75.796 1.00 10.31 C

ATOM 6941 CB PRO C 142 15.283 -5.808 75.960 1.00 10.19 C

ATOM 6942 CG PRO C 142 15.790 -6.018 74.586 1.00 10.11 C

ATOM 6943 CD PRO C 142 14.658 -6.654 73.836 1.00 10.07 C

ATOM 6944 C PRO C 142 12.985 -6.228 76.876 1.00 10.67 C

ATOM 6945 O PRO C 142 12.835 -7.446 76.812 1.00 10.68 O

ATOM 6946 N GLY C 143 12.458 -5.477 77.838 1.00 11.26 N

ATOM 6947 CA GLY C 143 11.723 -6.057 78.970 1.00 12.03 C

ATOM 6948 C GLY C 143 10.357 -6.639 78.637 1.00 12.66 C

ATOM 6949 O GLY C 143 -9.689 -7.197 79.509 1.00 12.69 O

ATOM 6950 N SER C 144 -9.944 -6.516 77.378 1.00 13.05 N

ATOM 6951 CA SER C 144 -8.643 -7.013 76.933 1.00 13.97 C

ATOM 6952 CB SER C 144 -8.788 -8.340 76.175 1.00 13.97 C

ATOM 6953 OG SER C 144 -8.907 -9.441 77.059 1.00 15.40 O

ATOM 6954 C SER C 144 -7.979 -6.004 76.028 1.00 14.11 C

ATOM 6955 O SER C 144 -8.614 -5.052 75.575 1.00 14.50 O

ATOM 6956 N ARG C 145 -6.690 -6.218 75.772 1.00 14.69 N

ATOM 6957 CA ARG C 145 -5.935 -5.441 74.795 1.00 14.77 C

ATOM 6958 CB ARG C 145 -6.430 -5.779 73.385 1.00 15.25 C

ATOM 6959 CG ARG C 145 -5.341 -6.189 72.425 1.00 15.40 C

ATOM 6960 CD ARG C 145 -5.918 -6.540 71.073 1.00 15.23 C

ATOM 6961 NE ARG C 145 -5.173 -5.858 70.022 1.00 16.72 N

ATOM 6962 CZ ARG C 145 -5.686 -4.971 69.175 1.00 16.27 C

ATOM 6963 NHl ARG C 145 -4.897 -4.403 68.276 1.00 16.04 N

ATOM 6964 NH2 ARG C 145 -6.979 -4.661 69.210 1.00 16.52 N

ATOM 6965 C ARG C 145 -5.983 -3.931 75.075 1.00 14.66 C

ATOM 6966 O ARG C 145 -6.129 -3.117 74.160 1.00 14.98 O

ATOM 6967 N GLY C 146 -5.857 -3.567 76.349 1.00 14.36 N

ATOM 6968 CA GLY C 146 -5.848 -2.163 76.761 1.00 13.94 C

ATOM 6969 C GLY C 146 -7.151 -1.682 77.373 1.00 13.62 C

ATOM 6970 O GLY C 146 -7.177 -0.666 78.075 1.00 13.58 O

ATOM 6971 N SER C 147 -8.231 -2.415 77.113 1.00 13.25 N

ATOM 6972 CA SER C 147 -9.552 -2.050 77.621 1.00 12.70 C W2025-7029WO / AM102903-PCT

ATOM 6973 CB SER C 147 10.647 -2.698 76.762 1.00 12.68 C

ATOM 6974 OG SER C 147 11.908 -2.654 77.398 1.00 11.59 O

ATOM 6975 C SER C 147 -9.703 -2.436 79.102 1.00 12.68 C

ATOM 6976 O SER C 147 -9.422 -3.575 79.473 1.00 12.30 O

ATOM 6977 N PRO C 148 10.140 -1.479 79.949 1.00 12.78 N

ATOM 6978 CA PRO C 148 10.313 -1.696 81.389 1.00 12.77 C

ATOM 6979 CB PRO C 148 10.575 -0.283 81.919 1.00 12.91 C

ATOM 6980 CG PRO C 148 11.208 0.421 80.782 1.00 13.02 C

ATOM 6981 CD PRO C 148 10.495 -0.099 79.567 1.00 12.67 C

ATOM 6982 C PRO C 148 11.487 -2.635 81.718 1.00 12.57 C

ATOM 6983 O PRO C 148 12.375 -2.812 80.884 1.00 12.42 O

ATOM 6984 N PRO C 149 11.483 -3.239 82.928 1.00 12.70 N

ATOM 6985 CA PRO C 149 12.439 -4.288 83.336 1.00 12.47 C

ATOM 6986 CB PRO C 149 12.015 -4.607 84.772 1.00 12.73 C

ATOM 6987 CG PRO C 149 10.583 -4.187 84.842 1.00 13.00 C

ATOM 6988 CD PRO C 149 10.512 -2.959 84.003 1.00 12.62 C

ATOM 6989 C PRO C 149 13.914 -3.883 83.310 1.00 12.18 C

ATOM 6990 O PRO C 149 14.777 -4.744 83.117 1.00 12.21 O

ATOM 6991 N GLN C 150 14.196 -2.594 83.498 1.00 11.64 N

ATOM 6992 CA GLN C 150 15.576 -2.095 83.481 1.00 11.32 C

ATOM 6993 CB GLN C 150 15.668 -0.656 84.017 1.00 11.33 C

ATOM 6994 CG GLN C 150 14.947 0.413 83.180 1.00 11.24 C

ATOM 6995 CD GLN C 150 13.536 0.708 83.675 1.00 11.80 C

ATOM 6996 OEl GLN C 150 12.852 -0.167 84.207 1.00 11.86 O

ATOM 6997 NE2 GLN C 150 13.098 1.952 83.501 1.00 11.25 N

ATOM 6998 C GLN C 150 16.214 -2.187 82.094 1.00 10.94 C

ATOM 6999 O GLN C 150 17.435 -2.125 81.970 1.00 10.51 O

ATOM 7000 N ASP C 151 15.381 -2.340 81.061 1.00 10.59 N

ATOM 7001 CA ASP C 151 15.870 -2.439 79.684 1.00 10.24 C

ATOM 7002 CB ASP C 151 14.729 -2.273 78.677 1.00 10.06 C

ATOM 7003 CG ASP C 151 14.302 -0.825 78.512 1.00 9.82 C

ATOM 7004 ODl ASP C 151 14.992 0.067 79.050 1.00 10.94 O

ATOM 7005 OD2 ASP C 151 13.280 -0.575 77.841 1.00 9.37 O

ATOM 7006 C ASP C 151 16.659 -3.716 79.395 1.00 10.06 C

ATOM 7007 O ASP C 151 17.449 -3.752 78.454 1.00 9.79 O

ATOM 7008 N LYS C 152 16.443 -4.751 80.203 1.00 9.86 N

ATOM 7009 CA LYS C 152 17.209 -5.989 80.092 1.00 9.89 C

ATOM 7010 CB LYS C 152 16.693 -7.046 81.085 1.00 9.90 C

ATOM 7011 CG LYS C 152 17.421 -8.388 81.024 1.00 10.10 C

ATOM 7012 CD LYS C 152 16.724 -9.461 81.861 1.00 10.36 C

ATOM 7013 CE LYS C 152 17.715 -10.541 82.296 1.00 11.44 C

ATOM 7014 NZ LYS C 152 17.059 -11.703 82.980 1.00 11.55 N

ATOM 7015 C LYS C 152 18.705 -5.711 80.282 1.00 9.61 C

ATOM 7016 O LYS C 152 19.516 -6.076 79.434 1.00 9.91 O

ATOM 7017 N HIS C 153 19.068 -5.049 81.376 1.00 9.32 N

ATOM 7018 CA HIS C 153 20.476 -4.733 81.612 1.00 8.93 C

ATOM 7019 CB HIS C 153 20.748 -4.405 83.081 1.00 8.96 C

ATOM 7020 CG HIS C 153 22.165 -3.993 83.351 1.00 8.96 C

ATOM 7021 NDl HIS C 153 23.230 -4.854 83.213 1.00 9.41 N

ATOM 7022 CEl HIS C 153 24.350 -4.218 83.507 1.00 9.72 C

ATOM 7023 NE2 HIS C 153 24.049 -2.973 83.826 1.00 9.41 N

ATOM 7024 CD2 HIS C 153 22.690 -2.804 83.731 1.00 9.54 C

ATOM 7025 C HIS C 153 20.984 -3.609 80.706 1.00 8.66 C

ATOM 7026 O HIS C 153 22.131 -3.640 80.258 1.00 8.39 O

ATOM 7027 N LEU C 154 20.132 -2.624 80.433 1.00 8.62 N

ATOM 7028 CA LEU C 154 20.542 -1.480 79.613 1.00 8.65 C

ATOM 7029 CB LEU C 154 19.538 -0.330 79.712 1.00 8.58 C

ATOM 7030 CG LEU C 154 19.509 0.414 81.053 1.00 9.40 C

ATOM 7031 CDl LEU C 154 18.298 1.319 81.117 1.00 9.48 C

ATOM 7032 CD2 LEU C 154 20.808 1.197 81.304 1.00 9.15 C

ATOM 7033 C LEU C 154 20.817 -1.847 78.149 1.00 8.38 C

ATOM 7034 O LEU C 154 21.604 -1.175 77.486 1.00 8.23 O

ATOM 7035 N PHE C 155 20.163 -2.898 77.653 1.00 8.12 N W2025-7029WO / AM102903-PCT

ATOM 7036 CA PHE C 155 20.470 -3.428 76.320 1.00 8.17 C

ATOM 7037 CB PHE C 155 19.447 -4.480 75.877 1.00 8.22 C

ATOM 7038 CG PHE C 155 19.651 -4.978 74.465 1.00 7.94 C

ATOM 7039 CDl PHE C 155 19.654 -4.096 73.391 1.00 8.20 C

ATOM 7040 CEl PHE C 155 19.835 -4.559 72.078 1.00 8.79 C

ATOM 7041 CZ PHE C 155 20.005 -5.925 71.838 1.00 7.72 C

ATOM 7042 CE2 PHE C 155 19.999 -6.814 72.907 1.00 7.73 C

ATOM 7043 CD2 PHE C 155 19.819 -6.339 74.210 1.00 8.41 C

ATOM 7044 C PHE C 155 21.888 -3.999 76.272 1.00 8.03 C

ATOM 7045 O PHE C 155 22.606 -3.787 75.296 1.00 7.91 O

ATOM 7046 N THR C 156 22.283 -4.710 77.328 1.00 7.87 N

ATOM 7047 CA THR C 156 23.660 -5.206 77.464 1.00 7.98 C

ATOM 7048 CB THR C 156 23.870 -5.979 78.793 1.00 8.01 C

ATOM 7049 OGl THR C 156 22.863 -6.987 78.937 1.00 7.85 O

ATOM 7050 CG2 THR C 156 25.252 -6.631 78.842 1.00 8.19 C

ATOM 7051 C THR C 156 24.655 -4.044 77.406 1.00 7.68 C

ATOM 7052 O THR C 156 25.667 -4.121 76.694 1.00 7.58 O

ATOM 7053 N VAL C 157 24.349 -2.980 78.152 1.00 7.29 N

ATOM 7054 CA VAL C 157 25.209 -1.799 78.262 1.00 7.40 C

ATOM 7055 CB VAL C 157 24.707 -0.812 79.358 1.00 7.45 C

ATOM 7056 CGl VAL C 157 25.431 0.524 79.265 1.00 7.73 C

ATOM 7057 CG2 VAL C 157 24.880 -1.403 80.754 1.00 8.21 C

ATOM 7058 C VAL C 157 25.338 -1.080 76.913 1.00 7.17 C

ATOM 7059 O VAL C 157 26.439 -0.702 76.512 1.00 6.76 O

ATOM 7060 N LEU C 158 24.212 -0.901 76.223 1.00 7.19 N

ATOM 7061 CA LEU C 158 24.215 -0.339 74.867 1.00 7.39 C

ATOM 7062 CB LEU C 158 22.785 -0.237 74.313 1.00 7.34 C

ATOM 7063 CG LEU C 158 22.597 0.050 72.812 1.00 7.26 C

ATOM 7064 CDl LEU C 158 22.975 1.490 72.462 1.00 7.93 C

ATOM 7065 CD2 LEU C 158 21.169 -0.241 72.401 1.00 7.28 C

ATOM 7066 C LEU C 158 25.103 -1.134 73.904 1.00 7.54 C

ATOM 7067 O LEU C 158 25.889 -0.552 73.156 1.00 7.80 O

ATOM 7068 N VAL C 159 24.979 -2.458 73.923 1.00 8.03 N

ATOM 7069 CA VAL C 159 25.761 -3.297 73.014 1.00 8.51 C

ATOM 7070 CB VAL C 159 25.223 -4.749 72.927 1.00 8.66 C

ATOM 7071 CGl VAL C 159 26.038 -5.561 71.913 1.00 8.12 C

ATOM 7072 CG2 VAL C 159 23.745 -4.754 72.526 1.00 8.27 C

ATOM 7073 C VAL C 159 27.258 -3.254 73.354 1.00 9.17 C

ATOM 7074 O VAL C 159 28.099 -3.168 72.451 1.00 9.16 O

ATOM 7075 N GLN C 160 27.578 -3.301 74.650 1.00 9.72 N

ATOM 7076 CA GLN C 160 28.952 -3.112 75.133 1.00 10.70 C

ATOM 7077 CB GLN C 160 28.984 -3.065 76.667 1.00 10.29 C

ATOM 7078 CG GLN C 160 30.360 -2.760 77.261 1.00 11.71 C

ATOM 7079 CD GLN C 160 30.319 -2.412 78.740 1.00 12.94 C

ATOM 7080 OEl GLN C 160 29.252 -2.147 79.311 1.00 16.63 O

ATOM 7081 NE2 GLN C 160 31.494 -2.400 79.374 1.00 16.53 N

ATOM 7082 C GLN C 160 29.566 -1.832 74.560 1.00 10.47 C

ATOM 7083 O GLN C 160 30.637 -1.863 73.949 1.00 10.86 O

ATOM 7084 N GLU C 161 28.869 -0.717 74.750 1.00 10.46 N

ATOM 7085 CA GLU C 161 29.350 0.589 74.301 1.00 10.58 C

ATOM 7086 CB GLU C 161 28.472 1.713 74.867 1.00 10.41 C

ATOM 7087 CG GLU C 161 28.583 1.869 76.388 1.00 10.41 C

ATOM 7088 CD GLU C 161 27.502 2.760 76.991 1.00 10.54 C

ATOM 7089 OEl GLU C 161 26.621 3.242 76.241 1.00 10.03 O

ATOM 7090 OE2 GLU C 161 27.529 2.967 78.225 1.00 9.76 O

ATOM 7091 C GLU C 161 29.463 0.677 72.778 1.00 10.64 C

ATOM 7092 O GLU C 161 30.423 1.234 72.263 1.00 10.44 O

ATOM 7093 N MET C 162 28.497 0.104 72.062 1.00 10.88 N

ATOM 7094 CA MET C 162 28.548 0.096 70.601 1.00 11.73 C

ATOM 7095 CB MET C 162 27.243 -0.427 70.001 1.00 11.41 C

ATOM 7096 CG MET C 162 27.275 -0.474 68.484 1.00 12.47 C

ATOM 7097 SD MET C 162 25.651 -0.524 67.717 1.00 13.76 S

ATOM 7098 CE MET C 162 25.068 1.139 68.057 1.00 13.23 C W2025-7029WO / AM102903-PCT

ATOM 7099 C MET C 162 29.737 -0.704 70.068 1.00 11.34 C

ATOM 7100 O MET C 162 30.488 -0.212 69.219 1.00 11.57 O

ATOM 7101 N ARG C 163 29.886 -1.935 70.559 1.00 11.27 N

ATOM 7102 CA ARG C 163 31.017 -2.802 70.210 1.00 11.47 C

ATOM 7103 CB ARG C 163 30.943 -4.130 71.000 1.00 11.30 C

ATOM 7104 CG ARG C 163 32.197 -5.015 70.962 1.00 11.40 C

ATOM 7105 CD ARG C 163 32.415 -5.709 69.623 1.00 10.91 C

ATOM 7106 NE ARG C 163 33.604 -6.567 69.643 1.00 10.06 N

ATOM 7107 CZ ARG C 163 33.598 -7.882 69.860 1.00 9.27 C

ATOM 7108 NHl ARG C 163 34.742 -8.555 69.857 1.00 8.02 N

ATOM 7109 NH2 ARG C 163 32.459 -8.531 70.081 1.00 9.68 N

ATOM 7110 C ARG C 163 32.359 -2.085 70.422 1.00 11.54 C

ATOM 7111 O ARG C 163 33.227 -2.116 69.546 1.00 11.23 O

ATOM 7112 N GLU C 164 32.498 -1.416 71.568 1.00 11.66 N

ATOM 7113 CA GLU C 164 33.706 -0.654 71.904 1.00 12.29 C

ATOM 7114 CB GLU C 164 33.649 -0.156 73.349 1.00 12.08 C

ATOM 7115 CG GLU C 164 33.986 -1.214 74.381 1.00 13.86 C

ATOM 7116 CD GLU C 164 33.951 -0.688 75.813 1.00 14.34 C

ATOM 7117 OEl GLU C 164 33.626 -1.481 76.729 1.00 16.65 O

ATOM 7118 OE2 GLU C 164 34.249 0.511 76.026 1.00 16.97 O

ATOM 7119 C GLU C 164 33.964 0.523 70.963 1.00 11.59 C

ATOM 7120 O GLU C 164 35.104 0.764 70.571 1.00 11.42 O

ATOM 7121 N ALA C 165 32.911 1.256 70.614 1.00 11.32 N

ATOM 7122 CA ALA C 165 33.032 2.376 69.683 1.00 11.55 C

ATOM 7123 CB ALA C 165 31.753 3.187 69.640 1.00 11.27 C

ATOM 7124 C ALA C 165 33.408 1.892 68.286 1.00 11.53 C

ATOM 7125 O ALA C 165 34.246 2.506 67.623 1.00 11.96 O

ATOM 7126 N PHE C 166 32.785 0.794 67.855 1.00 11.75 N

ATOM 7127 CA PHE C 166 33.131 0.120 66.598 1.00 11.99 C

ATOM 7128 CB PHE C 166 32.236 -1.109 66.385 1.00 11.46 C

ATOM 7129 CG PHE C 166 30.830 -0.787 65.916 1.00 10.56 C

ATOM 7130 CDl PHE C 166 30.377 0.529 65.821 1.00 10.09 C

ATOM 7131 CEl PHE C 166 29.080 0.809 65.397 1.00 10.71 C

ATOM 7132 CZ PHE C 166 28.215 -0.234 65.075 1.00 10.22 C

ATOM 7133 CE2 PHE C 166 28.651 -1.550 65.178 1.00 9.03 C

ATOM 7134 CD2 PHE C 166 29.949 -1.817 65.601 1.00 10.21 C

ATOM 7135 C PHE C 166 34.607 -0.292 66.581 1.00 12.71 C

ATOM 7136 O PHE C 166 35.304 -0.048 65.591 1.00 12.93 O

ATOM 7137 N GLU C 167 35.072 -0.897 67.680 1.00 13.44 N

ATOM 7138 CA GLU C 167 36.482 -1.305 67.844 1.00 14.22 C

ATOM 7139 CB GLU C 167 36.717 -1.971 69.210 1.00 14.29 C

ATOM 7140 CG GLU C 167 36.123 -3.368 69.383 1.00 14.74 C

ATOM 7141 CD GLU C 167 36.955 -4.491 68.758 1.00 15.55 C

ATOM 7142 OEl GLU C 167 38.103 -4.251 68.320 1.00 16.01 O

ATOM 7143 OE2 GLU C 167 36.448 -5.634 68.718 1.00 16.04 O

ATOM 7144 C GLU C 167 37.446 -0.126 67.691 1.00 14.65 C

ATOM 7145 O GLU C 167 38.472 -0.235 67.018 1.00 14.65 O

ATOM 7146 N GLN C 168 37.107 1.000 68.315 1.00 15.41 N

ATOM 7147 CA GLN C 168 37.971 2.179 68.287 1.00 15.87 C

ATOM 7148 CB GLN C 168 37.598 3.156 69.408 1.00 16.01 C

ATOM 7149 CG GLN C 168 37.763 2.592 70.831 1.00 16.77 C

ATOM 7150 CD GLN C 168 39.216 2.389 71.249 1.00 17.75 C

ATOM 7151 OEl GLN C 168 39.987 1.678 70.589 1.00 17.63 O

ATOM 7152 NE2 GLN C 168 39.591 3.000 72.368 1.00 19.03 N

ATOM 7153 C GLN C 168 37.977 2.870 66.918 1.00 16.04 C

ATOM 7154 O GLN C 168 39.041 3.249 66.420 1.00 16.03 O

ATOM 7155 N GLU C 169 36.793 3.014 66.317 1.00 16.20 N

ATOM 7156 CA GLU C 169 36.634 3.605 64.981 1.00 16.32 C

ATOM 7157 CB GLU C 169 35.146 3.720 64.612 1.00 16.32 C

ATOM 7158 CG GLU C 169 34.848 4.487 63.314 1.00 16.06 C

ATOM 7159 CD GLU C 169 34.609 3.581 62.098 1.00 15.92 C

ATOM 7160 OEl GLU C 169 34.878 2.361 62.165 1.00 15.26 O

ATOM 7161 OE2 GLU C 169 34.143 4.098 61.060 1.00 15.73 O W2025-7029WO / AM102903-PCT

ATOM 7162 C GLU C 169 37.394 2.833 63.899 1.00 16.73 C

ATOM 7163 O GLU C 169 37.906 3.432 62.950 1.00 16.62 O

ATOM 7164 N ALA C 170 37.453 1.509 64.044 1.00 17.06 N

ATOM 7165 CA ALA C 170 38.147 0.649 63.087 1.00 17.81 C

ATOM 7166 CB ALA C 170 37.926 -0.816 63.429 1.00 17.76 C

ATOM 7167 C ALA C 170 39.639 0.973 63.027 1.00 18.36 C

ATOM 7168 O ALA C 170 40.206 1.110 61.939 1.00 18.11 O

ATOM 7169 N LYS C 171 40.256 1.104 64.203 1.00 18.93 N

ATOM 7170 CA LYS C 171 41.657 1.514 64.326 1.00 19.78 C

ATOM 7171 CB LYS C 171 42.134 1.383 65.780 1.00 19.83 C

ATOM 7172 CG LYS C 171 42.291 -0.053 66.284 1.00 20.66 C

ATOM 7173 CD LYS C 171 43.634 -0.649 65.862 1.00 22.50 C

ATOM 7174 CE LYS C 171 43.714 -2.138 66.175 1.00 23.57 C

ATOM 7175 NZ LYS C 171 45.099 -2.683 65.994 1.00 24.48 N

ATOM 7176 C LYS C 171 41.842 2.954 63.851 1.00 20.11 C

ATOM 7177 O LYS C 171 42.842 3.281 63.204 1.00 20.27 O

ATOM 7178 N GLN C 172 40.863 3.799 64.173 1.00 20.45 N

ATOM 7179 CA GLN C 172 40.856 5.208 63.796 1.00 20.90 C

ATOM 7180 CB GLN C 172 39.612 5.892 64.373 1.00 21.06 C

ATOM 7181 CG GLN C 172 39.584 7.416 64.285 1.00 21.89 C

ATOM 7182 CD GLN C 172 38.232 8.006 64.689 1.00 22.01 C

ATOM 7183 OEl GLN C 172 37.204 7.315 64.691 1.00 23.24 O

ATOM 7184 NE2 GLN C 172 38.229 9.294 65.025 1.00 22.89 N

ATOM 7185 C GLN C 172 40.932 5.408 62.277 1.00 20.75 C

ATOM 7186 O GLN C 172 41.823 6.108 61.788 1.00 21.02 O

ATOM 7187 N ILE C 173 40.021 4.782 61.533 1.00 20.42 N

ATOM 7188 CA ILE C 173 39.934 5.017 60.082 1.00 20.28 C

ATOM 7189 CB ILE C 173 38.467 5.269 59.604 1.00 20.33 C

ATOM 7190 CGl ILE C 173 37.635 3.981 59.646 1.00 20.72 C

ATOM 7191 CDl ILE C 173 36.445 3.989 58.698 1.00 21.00 C

ATOM 7192 CG2 ILE C 173 37.819 6.381 60.428 1.00 20.77 C

ATOM 7193 C ILE C 173 40.620 3.957 59.208 1.00 19.81 C

ATOM 7194 O ILE C 173 40.508 3.993 57.976 1.00 19.53 O

ATOM 7195 N ASN C 174 41.328 3.028 59.851 1.00 19.49 N

ATOM 7196 CA ASN C 174 42.078 1.967 59.155 1.00 19.36 C

ATOM 7197 CB ASN C 174 43.242 2.558 58.339 1.00 19.87 C

ATOM 7198 CG ASN C 174 44.559 2.514 59.077 1.00 21.73 C

ATOM 7199 ODl ASN C 174 45.077 1.434 59.383 1.00 24.71 O

ATOM 7200 ND2 ASN C 174 45.130 3.692 59.346 1.00 24.29 N

ATOM 7201 C ASN C 174 41.231 1.030 58.279 1.00 18.58 C

ATOM 7202 O ASN C 174 41.638 0.666 57.175 1.00 18.53 O

ATOM 7203 N LYS C 175 40.061 0.643 58.784 1.00 17.73 N

ATOM 7204 CA LYS C 175 39.164 -0.269 58.077 1.00 16.95 C

ATOM 7205 CB LYS C 175 37.939 0.489 57.548 1.00 17.02 C

ATOM 7206 CG LYS C 175 38.187 1.285 56.276 1.00 17.78 C

ATOM 7207 CD LYS C 175 36.866 1.700 55.658 1.00 20.03 C

ATOM 7208 CE LYS C 175 37.035 2.758 54.576 1.00 21.06 C

ATOM 7209 NZ LYS C 175 35.698 3.133 54.027 1.00 21.49 N

ATOM 7210 C LYS C 175 38.718 -1.422 58.984 1.00 16.15 C

ATOM 7211 O LYS C 175 38.801 -1.305 60.205 1.00 16.13 O

ATOM 7212 N PRO C 176 38.251 -2.542 58.393 1.00 15.47 N

ATOM 7213 CA PRO C 176 37.665 -3.612 59.207 1.00 14.96 C

ATOM 7214 CB PRO C 176 37.096 -4.575 58.159 1.00 14.96 C

ATOM 7215 CG PRO C 176 37.958 -4.378 56.977 1.00 15.07 C

ATOM 7216 CD PRO C 176 38.257 -2.901 56.961 1.00 15.52 C

ATOM 7217 C PRO C 176 36.543 -3.098 60.105 1.00 14.39 C

ATOM 7218 O PRO C 176 35.779 -2.215 59.703 1.00 14.38 O

ATOM 7219 N ARG C 177 36.459 -3.652 61.310 1.00 13.50 N

ATOM 7220 CA ARG C 177 35.468 -3.237 62.296 1.00 12.69 C

ATOM 7221 CB ARG C 177 35.721 -3.968 63.622 1.00 12.87 C

ATOM 7222 CG ARG C 177 34.618 -3.806 64.653 1.00 12.84 C

ATOM 7223 CD ARG C 177 34.956 -4.461 65.974 1.00 11.90 C

ATOM 7224 NE ARG C 177 34.890 -5.921 65.972 1.00 10.78 N W2025-7029WO / AM102903-PCT

ATOM 7225 CZ ARG C 177 33.769 -6.640 66.044 1.00 11.70 C

ATOM 7226 NHl ARG C 177 32.578 -6.051 66.073 1.00 11.34 N

ATOM 7227 NH2 ARG C 177 33.840 -7.966 66.070 1.00 11.11 N

ATOM 7228 C ARG C 177 34.042 -3.491 61.811 1.00 12.30 C

ATOM 7229 O ARG C 177 33.758 -4.531 61.208 1.00 12.09 O

ATOM 7230 N LEU C 178 33.158 -2.530 62.072 1.00 11.95 N

ATOM 7231 CA LEU C 178 31.726 -2.710 61.852 1.00 11.59 C

ATOM 7232 CB LEU C 178 30.958 -1.401 62.097 1.00 11.63 C

ATOM 7233 CG LEU C 178 31.152 -0.237 61.114 1.00 11.22 C

ATOM 7234 CDl LEU C 178 30.650 1.070 61.708 1.00 11.04 C

ATOM 7235 CD2 LEU C 178 30.484 -0.506 59.763 1.00 10.34 C

ATOM 7236 C LEU C 178 31.197 -3.812 62.762 1.00 11.70 C

ATOM 7237 O LEU C 178 31.616 -3.926 63.915 1.00 11.35 O

ATOM 7238 N MET C 179 30.290 -4.627 62.227 1.00 11.54 N

ATOM 7239 CA MET C 179 29.681 -5.716 62.981 1.00 12.18 C

ATOM 7240 CB MET C 179 29.174 -6.803 62.030 1.00 11.92 C

ATOM 7241 CG MET C 179 30.245 -7.588 61.292 1.00 13.11 C

ATOM 7242 SD MET C 179 29.501 -8.680 60.058 1.00 15.43

ATOM 7243 CE MET C 179 28.376 -9.636 61.066 1.00 12.94 C

ATOM 7244 C MET C 179 28.502 -5.217 63.815 1.00 10.98 C

ATOM 7245 O MET C 179 27.804 -4.291 63.420 1.00 10.67 O

ATOM 7246 N VAL C 180 28.286 -5.846 64.965 1.00 10.24 N

ATOM 7247 CA VAL C 180 27.084 -5.602 65.757 1.00 9.47 C

ATOM 7248 CB VAL C 180 27.360 -4.751 67.049 1.00 9.45 C

ATOM 7249 CGl VAL C 180 28.378 -5.421 67.979 1.00 9.73 C

ATOM 7250 CG2 VAL C 180 26.057 -4.430 67.794 1.00 8.99 C

ATOM 7251 C VAL C 180 26.394 -6.934 66.054 1.00 9.12 C

ATOM 7252 O VAL C 180 26.976 -7.823 66.678 1.00 8.93 O

ATOM 7253 N THR C 181 25.160 -7.068 65.572 1.00 8.44 N

ATOM 7254 CA THR C 181 24.365 -8.282 65.772 1.00 8.08 C

ATOM 7255 CB THR C 181 24.197 -9.091 64.454 1.00 8.14 C

ATOM 7256 OGl THR C 181 23.479 -8.308 63.491 1.00 8.25 O

ATOM 7257 CG2 THR C 181 25.552 -9.480 63.864 1.00 7.86 C

ATOM 7258 C THR C 181 22.987 -7.933 66.353 1.00 7.95 C

ATOM 7259 O THR C 181 22.651 -6.751 66.513 1.00 7.48 O

ATOM 7260 N ALA C 182 22.208 -8.962 66.691 1.00 7.76 N

ATOM 7261 CA ALA C 182 20.843 -8.774 67.180 1.00 7.81 C

ATOM 7262 CB ALA C 182 20.828 -8.549 68.692 1.00 7.94 C

ATOM 7263 C ALA C 182 19.920 -9.926 66.818 1.00 7.71 C

ATOM 7264 O ALA C 182 20.303 -11.093 66.911 1.00 7.47 O

ATOM 7265 N ALA C 183 18.704 -9.578 66.397 1.00 7.65 N

ATOM 7266 CA ALA C 183 17.604 -10.536 66.322 1.00 7.67 C

ATOM 7267 CB ALA C 183 16.574 -10.104 65.273 1.00 7.56 C

ATOM 7268 C ALA C 183 16.967 -10.625 67.704 1.00 7.38 C

ATOM 7269 O ALA C 183 16.648 -9.599 68.316 1.00 7.55 O

ATOM 7270 N VAL C 184 16.791 -11.848 68.194 1.00 7.13 N

ATOM 7271 CA VAL C 184 16.345 -12.075 69.571 1.00 6.73 C

ATOM 7272 CB VAL C 184 17.493 -12.633 70.463 1.00 6.63 C

ATOM 7273 CGl VAL C 184 18.607 -11.608 70.619 1.00 5.90 C

ATOM 7274 CG2 VAL C 184 18.024 -13.947 69.902 1.00 6.69 C

ATOM 7275 C VAL C 184 15.143 -13.012 69.675 1.00 6.90 C

ATOM 7276 O VAL C 184 14.867 -13.799 68.757 1.00 6.81 O

ATOM 7277 N ALA C 185 14.471 -12.939 70.824 1.00 6.97 N

ATOM 7278 CA ALA C 185 13.233 -13.666 71.099 1.00 7.07 C

ATOM 7279 CB ALA C 185 12.647 -13.207 72.446 1.00 6.80 C

ATOM 7280 C ALA C 185 13.392 -15.187 71.092 1.00 7.18 C

ATOM 7281 O ALA C 185 14.445 -15.719 71.467 1.00 6.88 O

ATOM 7282 N ALA C 186 12.332 -15.871 70.666 1.00 7.19 N

ATOM 7283 CA ALA C 186 12.238 -17.327 70.777 1.00 7.58 C

ATOM 7284 CB ALA C 186 11.739 -17.930 69.474 1.00 7.61 C

ATOM 7285 C ALA C 186 11.342 -17.761 71.950 1.00 7.77 C

ATOM 7286 O ALA C 186 11.434 -18.899 72.420 1.00 7.64 O

ATOM 7287 N GLY C 187 10.480 -16.854 72.415 1.00 7.83 N W2025-7029WO / AM102903-PCT

ATOM 7288 CA GLY C 187 -9.583 -17.147 73.534 1.00 8.09 C

ATOM 7289 C GLY C 187 10.360 -17.181 74.839 1.00 8.30 C

ATOM 7290 O GLY C 187 11.114 -16.256 75.135 1.00 8.46 O

ATOM 7291 N ILE C 188 10.183 -18.247 75.615 1.00 8.42 N

ATOM 7292 CA ILE C 188 11.014 -18.466 76.806 1.00 8.64 C

ATOM 7293 CB ILE C 188 10.794 -19.877 77.429 1.00 8.61 C

ATOM 7294 CGl ILE C 188 11.077 -20.980 76.397 1.00 8.09 C

ATOM 7295 CDl ILE C 188 12.462 -20.922 75.718 1.00 5.84 C

ATOM 7296 CG2 ILE C 188 11.625 -20.065 78.730 1.00 8.56 C

ATOM 7297 C ILE C 188 10.860 -17.359 77.849 1.00 8.93 C

ATOM 7298 O ILE C 188 11.863 -16.854 78.356 1.00 8.84 O

ATOM 7299 N SER C 189 -9.625 -16.959 78.148 1.00 9.27 N

ATOM 7300 CA SER C 189 -9.403 -15.866 79.108 1.00 9.88 C

ATOM 7301 CB SER C 189 -7.918 -15.709 79.465 1.00 10.04 C

ATOM 7302 OG SER C 189 -7.155 -15.322 78.338 1.00 12.19 O

ATOM 7303 C SER C 189 -9.991 -14.540 78.620 1.00 9.79 C

ATOM 7304 O SER C 189 10.496 -13.752 79.424 1.00 9.82 O

ATOM 7305 N ASN C 190 -9.937 -14.306 77.308 1.00 9.80 N

ATOM 7306 CA ASN C 190 10.527 -13.104 76.707 1.00 9.98 C

ATOM 7307 CB ASN C 190 10.059 -12.930 75.258 1.00 10.31 C

ATOM 7308 CG ASN C 190 -8.557 -12.712 75.144 1.00 11.61 C

ATOM 7309 ODl ASN C 190 -7.951 -11.985 75.941 1.00 12.75 O

ATOM 7310 ND2 ASN C 190 -7.952 -13.329 74.138 1.00 12.44 N

ATOM 7311 C ASN C 190 12.057 -13.109 76.764 1.00 9.55 C

ATOM 7312 O ASN C 190 12.677 -12.067 76.946 1.00 9.81 O

ATOM 7313 N ILE C 191 12.656 -14.284 76.593 1.00 9.41 N

ATOM 7314 CA ILE C 191 14.106 -14.451 76.720 1.00 8.93 C

ATOM 7315 CB ILE C 191 14.556 -15.880 76.292 1.00 8.93 C

ATOM 7316 CGl ILE C 191 14.292 -16.110 74.799 1.00 8.70 C

ATOM 7317 CDl ILE C 191 14.344 -17.562 74.373 1.00 8.14 C

ATOM 7318 CG2 ILE C 191 16.038 -16.095 76.566 1.00 9.22 C

ATOM 7319 C ILE C 191 14.548 -14.140 78.160 1.00 9.32 C

ATOM 7320 O ILE C 191 15.554 -13.450 78.382 1.00 8.99 O

ATOM 7321 N GLN C 192 13.771 -14.625 79.127 1.00 9.25 N

ATOM 7322 CA GLN C 192 14.081 -14.450 80.550 1.00 9.67 C

ATOM 7323 CB GLN C 192 13.214 -15.386 81.400 1.00 9.60 C

ATOM 7324 CG GLN C 192 13.569 -16.871 81.241 1.00 10.03 C

ATOM 7325 CD GLN C 192 12.593 -17.805 81.946 1.00 10.69 C

ATOM 7326 OEl GLN C 192 11.468 -17.422 82.278 1.00 12.96 O

ATOM 7327 NE2 GLN C 192 13.019 -19.044 82.166 1.00 12.89 N

ATOM 7328 C GLN C 192 13.969 -12.998 81.038 1.00 9.51 C

ATOM 7329 O GLN C 192 14.793 -12.539 81.834 1.00 9.87 O

ATOM 7330 N SER C 193 12.962 -12.277 80.553 1.00 9.26 N

ATOM 7331 CA SER C 193 12.804 -10.857 80.880 1.00 8.95 C

ATOM 7332 CB SER C 193 11.329 -10.451 80.825 1.00 8.92 C

ATOM 7333 OG SER C 193 10.776 -10.689 79.542 1.00 9.32 O

ATOM 7334 C SER C 193 13.633 -9.925 79.983 1.00 8.73 C

ATOM 7335 O SER C 193 13.764 -8.735 80.280 1.00 8.66 O

ATOM 7336 N GLY C 194 14.201 -10.473 78.908 1.00 8.16 N

ATOM 7337 CA GLY C 194 14.819 -9.657 77.865 1.00 7.99 C

ATOM 7338 C GLY C 194 16.331 -9.527 77.823 1.00 7.72 C

ATOM 7339 O GLY C 194 16.852 -8.461 77.492 1.00 7.83 O

ATOM 7340 N TYR C 195 17.039 -10.605 78.138 1.00 7.35 N

ATOM 7341 CA TYR C 195 18.474 -10.678 77.848 1.00 7.43 C

ATOM 7342 CB TYR C 195 18.720 -11.549 76.605 1.00 7.13 C

ATOM 7343 CG TYR C 195 17.761 -11.250 75.475 1.00 7.39 C

ATOM 7344 CDl TYR C 195 16.628 -12.041 75.267 1.00 6.53 C

ATOM 7345 CEl TYR C 195 15.731 -11.752 74.236 1.00 7.12 C

ATOM 7346 CZ TYR C 195 15.961 -10.657 73.411 1.00 7.00 C

ATOM 7347 OH TYR C 195 15.085 -10.367 72.392 1.00 7.37 O

ATOM 7348 CE2 TYR C 195 17.073 -9.855 73.599 1.00 6.69 C

ATOM 7349 CD2 TYR C 195 17.966 -10.152 74.633 1.00 6.78 C

ATOM 7350 C TYR C 195 19.306 -11.203 79.011 1.00 7.51 C W2025-7029WO / AM102903-PCT

ATOM 7351 O TYR C 195 18.899 -12.128 79.711 1.00 7.49 O

ATOM 7352 N GLU C 196 20.471 -10.593 79.203 1.00 7.93 N

ATOM 7353 CA GLU C 196 21.494 -11.131 80.093 1.00 8.24 C

ATOM 7354 CB GLU C 196 22.236 -10.004 80.815 1.00 8.18 C

ATOM 7355 CG GLU C 196 21.344 -9.049 81.617 1.00 8.59 C

ATOM 7356 CD GLU C 196 22.134 -7.920 82.259 1.00 9.20 C

ATOM 7357 OEl GLU C 196 21.894 -7.614 83.444 1.00 10.94 O

ATOM 7358 OE2 GLU C 196 23.011 -7.347 81.583 1.00 9.96 O

ATOM 7359 C GLU C 196 22.434 -11.916 79.181 1.00 8.10 C

ATOM 7360 O GLU C 196 23.417 -11.368 78.666 1.00 8.06 O

ATOM 7361 N ILE C 197 22.105 -13.190 78.969 1.00 7.95 N

ATOM 7362 CA ILE C 197 22.685 -13.995 77.882 1.00 7.49 C

ATOM 7363 CB ILE C 197 21.951 -15.364 77.714 1.00 7.44 C

ATOM 7364 CGl ILE C 197 20.465 -15.134 77.392 1.00 7.00 C

ATOM 7365 CDl ILE C 197 19.592 -16.377 77.552 1.00 7.56 C

ATOM 7366 CG2 ILE C 197 22.603 -16.221 76.625 1.00 7.39 C

ATOM 7367 C ILE C 197 24.220 -14.145 77.944 1.00 7.54 C

ATOM 7368 O ILE C 197 24.891 -13.880 76.945 1.00 7.31 O

ATOM 7369 N PRO C 198 24.774 -14.582 79.098 1.00 7.33 N

ATOM 7370 CA PRO C 198 26.234 -14.686 79.177 1.00 7.57 C

ATOM 7371 CB PRO C 198 26.478 -15.061 80.646 1.00 7.65 C

ATOM 7372 CG PRO C 198 25.239 -15.803 81.037 1.00 7.49 C

ATOM 7373 CD PRO C 198 24.133 -15.049 80.344 1.00 7.31 C

ATOM 7374 C PRO C 198 27.000 -13.408 78.783 1.00 7.57 C

ATOM 7375 O PRO C 198 27.914 -13.485 77.962 1.00 7.47 O

ATOM 7376 N GLN C 199 26.633 -12.255 79.343 1.00 7.91 N

ATOM 7377 CA GLN C 199 27.368 -11.009 79.069 1.00 7.98 C

ATOM 7378 CB GLN C 199 27.102 -9.950 80.149 1.00 8.06 C

ATOM 7379 CG GLN C 199 28.036 -8.728 80.070 1.00 8.84 C

ATOM 7380 CD GLN C 199 29.490 -9.068 80.368 1.00 8.91 C

ATOM 7381 OEl GLN C 199 29.898 -9.132 81.524 1.00 10.75 O

ATOM 7382 NE2 GLN C 199 30.279 -9.282 79.320 1.00 9.71 N

ATOM 7383 C GLN C 199 27.084 -10.436 77.677 1.00 8.06 C

ATOM 7384 O GLN C 199 28.000 -9.976 76.978 1.00 7.71 O

ATOM 7385 N LEU C 200 25.816 -10.459 77.280 1.00 8.03 N

ATOM 7386 CA LEU C 200 25.425 -9.968 75.963 1.00 8.10 C

ATOM 7387 CB LEU C 200 23.901 -10.029 75.796 1.00 8.08 C

ATOM 7388 CG LEU C 200 23.276 -9.542 74.483 1.00 7.84 C

ATOM 7389 CDl LEU C 200 23.518 -8.055 74.245 1.00 6.37 C

ATOM 7390 CD2 LEU C 200 21.781 -9.848 74.468 1.00 7.63 C

ATOM 7391 C LEU C 200 26.135 -10.730 74.842 1.00 8.44 C

ATOM 7392 O LEU C 200 26.568 -10.136 73.854 1.00 8.42 O

ATOM 7393 N SER C 201 26.268 -12.044 75.017 1.00 8.74 N

ATOM 7394 CA SER C 201 26.882 -12.905 74.006 1.00 9.14 C

ATOM 7395 CB SER C 201 26.649 -14.374 74.356 1.00 9.18 C

ATOM 7396 OG SER C 201 25.258 -14.637 74.476 1.00 10.10 O

ATOM 7397 C SER C 201 28.376 -12.638 73.785 1.00 9.23 C

ATOM 7398 O SER C 201 28.922 -13.025 72.754 1.00 9.63 O

ATOM 7399 N GLN C 202 29.026 -11.989 74.752 1.00 9.27 N

ATOM 7400 CA GLN C 202 30.440 -11.610 74.628 1.00 9.32 C

ATOM 7401 CB GLN C 202 31.048 -11.293 76.005 1.00 9.48 C

ATOM 7402 CG GLN C 202 30.862 -12.374 77.069 1.00 10.80 C

ATOM 7403 CD GLN C 202 31.130 -13.792 76.572 1.00 12.80 C

ATOM 7404 OEl GLN C 202 32.194 -14.087 76.015 1.00 13.45 O

ATOM 7405 NE2 GLN C 202 30.157 -14.681 76.783 1.00 12.13 N

ATOM 7406 C GLN C 202 30.647 -10.417 73.691 1.00 8.88 C

ATOM 7407 O GLN C 202 31.740 -10.235 73.139 1.00 8.94 O

ATOM 7408 N TYR C 203 29.595 -9.622 73.506 1.00 8.45 N

ATOM 7409 CA TYR C 203 29.677 -8.375 72.742 1.00 8.43 C

ATOM 7410 CB TYR C 203 28.977 -7.234 73.495 1.00 8.40 C

ATOM 7411 CG TYR C 203 29.488 -6.988 74.904 1.00 8.53 C

ATOM 7412 CDl TYR C 203 28.602 -6.849 75.971 1.00 7.85 C

ATOM 7413 CEl TYR C 203 29.060 -6.614 77.260 1.00 7.81 C W2025-7029WO / AM102903-PCT

ATOM 7414 CZ TYR C 203 30.425 -6.512 77.499 1.00 8.13 C

ATOM 7415 OH TYR C 203 30.876 -6.277 78.782 1.00 8.28 O

ATOM 7416 CE2 TYR C 203 31.326 -6.651 76.463 1.00 7.96 C

ATOM 7417 CD2 TYR C 203 30.855 -6.887 75.169 1.00 9.19 C

ATOM 7418 C TYR C 203 29.105 -8.487 71.332 1.00 8.51 C

ATOM 7419 O TYR C 203 29.639 -7.888 70.394 1.00 8.32 O

ATOM 7420 N LEU C 204 28.019 -9.247 71.193 1.00 8.47 N

ATOM 7421 CA LEU C 204 27.407 -9.504 69.889 1.00 8.59 C

ATOM 7422 CB LEU C 204 26.019 -10.131 70.052 1.00 8.28 C

ATOM 7423 CG LEU C 204 24.862 -9.272 70.571 1.00 8.61 C

ATOM 7424 CDl LEU C 204 23.631 -10.142 70.804 1.00 7.48 C

ATOM 7425 CD2 LEU C 204 24.548 -8.143 69.599 1.00 8.44 C

ATOM 7426 C LEU C 204 28.266 -10.422 69.028 1.00 8.81 C

ATOM 7427 O LEU C 204 28.825 -11.406 69.513 1.00 8.83 O

ATOM 7428 N ASP C 205 28.352 -10.096 67.745 1.00 8.95 N

ATOM 7429 CA ASP C 205 29.040 -10.935 66.774 1.00 9.20 C

ATOM 7430 CB ASP C 205 29.358 -10.126 65.514 1.00 9.24 C

ATOM 7431 CG ASP C 205 30.486 -9.133 65.738 1.00 10.14 C

ATOM 7432 ODl ASP C 205 31.607 -9.580 66.063 1.00 11.04 O

ATOM 7433 OD2 ASP C 205 30.251 -7.915 65.600 1.00 10.11 O

ATOM 7434 C ASP C 205 28.216 -12.165 66.428 1.00 9.13 C

ATOM 7435 O ASP C 205 28.743 -13.274 66.360 1.00 9.16 O

ATOM 7436 N TYR C 206 26.925 -11.957 66.185 1.00 9.16 N

ATOM 7437 CA TYR C 206 26.006 -13.051 65.912 1.00 8.99 C

ATOM 7438 CB TYR C 206 25.817 -13.274 64.403 1.00 9.55 C

ATOM 7439 CG TYR C 206 27.075 -13.743 63.708 1.00 10.42 C

ATOM 7440 CDl TYR C 206 27.884 -12.845 63.016 1.00 11.02 C

ATOM 7441 CEl TYR C 206 29.052 -13.267 62.388 1.00 10.94 C

ATOM 7442 CZ TYR C 206 29.423 -14.598 62.460 1.00 11.14 C

ATOM 7443 OH TYR C 206 30.581 -15.014 61.849 1.00 11.43 O

ATOM 7444 CE2 TYR C 206 28.645 -15.509 63.151 1.00 11.35 C

ATOM 7445 CD2 TYR C 206 27.475 -15.079 63.772 1.00 11.28 C

ATOM 7446 C TYR C 206 24.673 -12.787 66.585 1.00 8.30 C

ATOM 7447 O TYR C 206 24.292 -11.639 66.811 1.00 7.89 O

ATOM 7448 N ILE C 207 23.983 -13.872 66.915 1.00 7.72 N

ATOM 7449 CA ILE C 207 22.694 -13.806 67.582 1.00 7.19 C

ATOM 7450 CB ILE C 207 22.754 -14.459 68.990 1.00 7.26 C

ATOM 7451 CGl ILE C 207 23.876 -13.825 69.823 1.00 7.45 C

ATOM 7452 CDl ILE C 207 24.346 -14.659 71.004 1.00 7.89 C

ATOM 7453 CG2 ILE C 207 21.418 -14.315 69.709 1.00 6.77 C

ATOM 7454 C ILE C 207 21.684 -14.495 66.671 1.00 6.79 C

ATOM 7455 O ILE C 207 21.755 -15.705 66.453 1.00 6.70 O

ATOM 7456 N HIS C 208 20.773 -13.706 66.108 1.00 6.62 N

ATOM 7457 CA HIS C 208 19.767 -14.222 65.188 1.00 6.32 C

ATOM 7458 CB HIS C 208 19.481 -13.208 64.075 1.00 6.15 C

ATOM 7459 CG HIS C 208 20.704 -12.738 63.349 1.00 5.98 C

ATOM 7460 NDl HIS C 208 21.029 -11.406 63.226 1.00 5.43 N

ATOM 7461 CEl HIS C 208 22.147 -11.290 62.530 1.00 6.30 C

ATOM 7462 NE2 HIS C 208 22.566 -12.500 62.208 1.00 5.95 N

ATOM 7463 CD2 HIS C 208 21.679 -13.425 62.706 1.00 5.74 C

ATOM 7464 C HIS C 208 18.483 -14.571 65.937 1.00 6.33 C

ATOM 7465 O HIS C 208 17.662 -13.694 66.212 1.00 6.46 O

ATOM 7466 N VAL C 209 18.314 -15.851 66.268 1.00 6.15 N

ATOM 7467 CA VAL C 209 17.143 -16.301 67.028 1.00 6.20 C

ATOM 7468 CB VAL C 209 17.400 -17.623 67.802 1.00 5.88 C

ATOM 7469 CGl VAL C 209 16.255 -17.903 68.759 1.00 5.94 C

ATOM 7470 CG2 VAL C 209 18.707 -17.543 68.587 1.00 6.05 C

ATOM 7471 C VAL C 209 15.924 -16.452 66.114 1.00 6.27 C

ATOM 7472 O VAL C 209 15.978 -17.155 65.101 1.00 5.96 O

ATOM 7473 N MET C 210 14.832 -15.789 66.489 1.00 6.51 N

ATOM 7474 CA MET C 210 13.617 -15.752 65.671 1.00 7.08 C

ATOM 7475 CB MET C 210 12.864 -14.433 65.890 1.00 7.11 C

ATOM 7476 CG MET C 210 13.613 -13.215 65.342 1.00 7.42 C W2025-7029WO / AM102903-PCT

ATOM 7477 SD MET C 210 12.813 -11.620 65.602 1.00 8.30

ATOM 7478 CE MET C 210 12.972 -11.436 67.366 1.00 7.31 C

ATOM 7479 C MET C 210 12.725 -16.973 65.903 1.00 6.94 C

ATOM 7480 O MET C 210 11.595 -16.862 66.394 1.00 7.36 O

ATOM 7481 N THR C 211 13.258 -18.137 65.535 1.00 6.92 N

ATOM 7482 CA THR C 211 12.580 -19.429 65.671 1.00 6.75 C

ATOM 7483 CB THR C 211 13.584 -20.610 65.628 1.00 6.70 C

ATOM 7484 OGl THR C 211 14.519 -20.408 64.562 1.00 6.85 O

ATOM 7485 CG2 THR C 211 14.344 -20.716 66.930 1.00 6.81 C

ATOM 7486 C THR C 211 11.483 -19.634 64.617 1.00 6.61 C

ATOM 7487 O THR C 211 11.503 -20.597 63.838 1.00 6.44 O

ATOM 7488 N TYR C 212 10.530 -18.706 64.608 1.00 6.31 N

ATOM 7489 CA TYR C 212 -9.334 -18.790 63.782 1.00 6.26 C

ATOM 7490 CB TYR C 212 -9.596 -18.275 62.353 1.00 6.12 C

ATOM 7491 CG TYR C 212 10.517 -17.079 62.249 1.00 5.78 C

ATOM 7492 CDl TYR C 212 10.074 -15.802 62.589 1.00 5.40 C

ATOM 7493 CEl TYR C 212 10.912 -14.694 62.489 1.00 5.73 C

ATOM 7494 CZ TYR C 212 12.204 -14.853 62.035 1.00 5.45 C

ATOM 7495 OH TYR C 212 13.016 -13.743 61.935 1.00 6.35 O

ATOM 7496 CE2 TYR C 212 12.677 -16.110 61.673 1.00 5.77 C

ATOM 7497 CD2 TYR C 212 11.831 -17.218 61.779 1.00 5.75 C

ATOM 7498 C TYR C 212 -8.212 -18.025 64.485 1.00 6.36 C

ATOM 7499 O TYR C 212 -8.442 -17.437 65.546 1.00 6.38 O

ATOM 7500 N ASP C 213 -7.010 -18.037 63.906 1.00 6.38 N

ATOM 7501 CA ASP C 213 -5.799 -17.530 64.578 1.00 6.41 C

ATOM 7502 CB ASP C 213 -5.865 -16.009 64.822 1.00 6.45 C

ATOM 7503 CG ASP C 213 -6.190 -15.221 63.564 1.00 6.63 C

ATOM 7504 ODl ASP C 213 -5.577 -15.501 62.510 1.00 6.81 O

ATOM 7505 OD2 ASP C 213 -7.056 -14.317 63.636 1.00 7.41 O

ATOM 7506 C ASP C 213 -5.566 -18.262 65.903 1.00 6.37 C

ATOM 7507 O ASP C 213 -5.035 -17.686 66.856 1.00 5.88 O

ATOM 7508 N LEU C 214 -5.970 -19.533 65.958 1.00 6.53 N

ATOM 7509 CA LEU C 214 -5.869 -20.311 67.196 1.00 6.53 C

ATOM 7510 CB LEU C 214 -6.849 -21.491 67.188 1.00 6.63 C

ATOM 7511 CG LEU C 214 -8.342 -21.130 67.091 1.00 6.61 C

ATOM 7512 CDl LEU C 214 -9.193 -22.381 66.944 1.00 6.18 C

ATOM 7513 CD2 LEU C 214 -8.811 -20.304 68.284 1.00 6.97 C

ATOM 7514 C LEU C 214 -4.431 -20.758 67.463 1.00 6.68 C

ATOM 7515 O LEU C 214 -4.066 -21.054 68.603 1.00 7.00 O

ATOM 7516 N HIS C 215 -3.631 -20.788 66.399 1.00 6.72 N

ATOM 7517 CA HIS C 215 -2.178 -20.970 66.477 1.00 6.71 C

ATOM 7518 CB HIS C 215 -1.783 -22.416 66.186 1.00 6.24 C

ATOM 7519 CG HIS C 215 -2.278 -23.402 67.195 1.00 6.52 C

ATOM 7520 NDl HIS C 215 -1.717 -23.531 68.447 1.00 5.97 N

ATOM 7521 CEl HIS C 215 -2.354 -24.480 69.112 1.00 6.67 C

ATOM 7522 NE2 HIS C 215 -3.300 -24.975 68.334 1.00 5.78 N

ATOM 7523 CD2 HIS C 215 -3.269 -24.323 67.126 1.00 6.66 C

ATOM 7524 C HIS C 215 -1.515 -20.079 65.438 1.00 6.71 C

ATOM 7525 O HIS C 215 -2.139 -19.706 64.448 1.00 6.68 O

ATOM 7526 N GLY C 216 -0.240 -19.768 65.656 1.00 7.03 N

ATOM 7527 CA GLY C 216 0.545 -18.956 64.728 1.00 7.26 C

ATOM 7528 C GLY C 216 1.985 -18.868 65.196 1.00 7.67 C

ATOM 7529 O GLY C 216 2.326 -19.372 66.275 1.00 7.21 O

ATOM 7530 N SER C 217 2.830 -18.220 64.394 1.00 7.81 N

ATOM 7531 CA SER C 217 4.271 -18.184 64.663 1.00 8.52 C

ATOM 7532 CB SER C 217 5.029 -17.487 63.531 1.00 8.20 C

ATOM 7533 OG SER C 217 4.596 -16.148 63.370 1.00 8.48 O

ATOM 7534 C SER C 217 4.615 -17.549 66.006 1.00 8.66 C

ATOM 7535 O SER C 217 5.676 -17.812 66.564 1.00 9.14 O

ATOM 7536 N TRP C 218 3.708 -16.725 66.523 1.00 8.87 N

ATOM 7537 CA TRP C 218 3.894 -16.099 67.828 1.00 8.93 C

ATOM 7538 CB TRP C 218 2.719 -15.177 68.178 1.00 8.94 C

ATOM 7539 CG TRP C 218 1.360 -15.798 68.071 1.00 8.62 C W2025-7029WO / AM102903-PCT

ATOM 7540 CDl TRP C 218 0.705 -16.505 69.036 1.00 8.25 C

ATOM 7541 NEl TRP C 218 0.526 -16.907 68.577 1.00 8.35 N

ATOM 7542 CE2 TRP C 218 0.696 -16.448 67.296 1.00 8.58 C

ATOM 7543 CD2 TRP C 218 0.477 -15.745 66.941 1.00 8.85 C

ATOM 7544 CE3 TRP C 218 0.565 -15.173 65.660 1.00 8.95 C

ATOM 7545 CZ3 TRP C 218 0.508 -15.324 64.785 1.00 8.50 C

ATOM 7546 CH2 TRP C 218 1.667 -16.033 65.169 1.00 8.83 C

ATOM 7547 CZ2 TRP C 218 1.778 -16.603 66.415 1.00 9.40 C

ATOM 7548 C TRP C 218 4.152 -17.084 68.961 1.00 8.98 C

ATOM 7549 O TRP C 218 4.692 -16.704 69.992 1.00 8.77 O

ATOM 7550 N GLU C 219 3.788 -18.351 68.749 1.00 9.24 N

ATOM 7551 CA GLU C 219 3.946 -19.398 69.762 1.00 9.62 C

ATOM 7552 CB GLU C 219 2.841 -20.447 69.616 1.00 9.32 C

ATOM 7553 CG GLU C 219 1.466 -19.922 70.000 1.00 10.06 C

ATOM 7554 CD GLU C 219 0.375 -20.964 69.853 1.00 10.20 C

ATOM 7555 OEl GLU C 219 0.295 -21.608 68.785 1.00 10.59 O

ATOM 7556 OE2 GLU C 219 0.412 -21.122 70.808 1.00 11.52 O

ATOM 7557 C GLU C 219 5.315 -20.081 69.757 1.00 9.44 C

ATOM 7558 O GLU C 219 5.675 -20.748 70.720 1.00 9.51 O

ATOM 7559 N GLY C 220 6.067 -19.925 68.671 1.00 9.66 N

ATOM 7560 CA GLY C 220 7.387 -20.533 68.564 1.00 9.85 C

ATOM 7561 C GLY C 220 7.396 -21.981 68.103 1.00 10.27 C

ATOM 7562 O GLY C 220 8.441 -22.629 68.129 1.00 10.26 O

ATOM 7563 N TYR C 221 6.234 -22.480 67.676 1.00 10.21 N

ATOM 7564 CA TYR C 221 6.096 -23.814 67.077 1.00 10.14 C

ATOM 7565 CB TYR C 221 5.912 -24.892 68.154 1.00 10.71 C

ATOM 7566 CG TYR C 221 4.951 -24.522 69.270 1.00 12.01 C

ATOM 7567 CDl TYR C 221 3.566 -24.665 69.109 1.00 12.42 C

ATOM 7568 CEl TYR C 221 2.679 -24.322 70.134 1.00 13.04 C

ATOM 7569 CZ TYR C 221 3.183 -23.834 71.340 1.00 13.10 C

ATOM 7570 OH TYR C 221 2.321 -23.500 72.365 1.00 12.18 O

ATOM 7571 CE2 TYR C 221 4.554 -23.691 71.523 1.00 12.85 C

ATOM 7572 CD2 TYR C 221 5.429 -24.033 70.490 1.00 12.15 C

ATOM 7573 C TYR C 221 4.936 -23.859 66.075 1.00 9.79 C

ATOM 7574 O TYR C 221 4.028 -23.020 66.134 1.00 9.36 O

ATOM 7575 N THR C 222 4.970 -24.836 65.163 1.00 9.41 N

ATOM 7576 CA THR C 222 3.899 -25.013 64.177 1.00 8.73 C

ATOM 7577 CB THR C 222 4.203 -26.125 63.147 1.00 9.01 C

ATOM 7578 OGl THR C 222 4.291 -27.387 63.815 1.00 8.52 O

ATOM 7579 CG2 THR C 222 5.490 -25.845 62.376 1.00 8.63 C

ATOM 7580 C THR C 222 2.577 -25.359 64.854 1.00 8.45 C

ATOM 7581 O THR C 222 2.546 -26.057 65.871 1.00 8.20 O

ATOM 7582 N GLY C 223 1.491 -24.858 64.277 1.00 8.15 N

ATOM 7583 CA GLY C 223 0.155 -25.090 64.801 1.00 7.63 C

ATOM 7584 C GLY C 223 0.856 -24.698 63.751 1.00 7.64 C

ATOM 7585 O GLY C 223 0.547 -23.921 62.842 1.00 7.20 O

ATOM 7586 N GLU C 224 2.066 -25.236 63.883 1.00 7.30 N

ATOM 7587 CA GLU C 224 3.118 -25.026 62.894 1.00 7.12 C

ATOM 7588 CB GLU C 224 4.036 -26.253 62.819 1.00 7.43 C

ATOM 7589 CG GLU C 224 3.395 -27.442 62.114 1.00 7.25 C

ATOM 7590 CD GLU C 224 3.465 -27.345 60.605 1.00 7.66 C

ATOM 7591 OEl GLU C 224 3.850 -26.276 60.079 1.00 7.32 O

ATOM 7592 OE2 GLU C 224 3.140 -28.354 59.939 1.00 8.46 O

ATOM 7593 C GLU C 224 3.931 -23.770 63.162 1.00 6.82 C

ATOM 7594 O GLU C 224 4.202 -23.424 64.313 1.00 6.35 O

ATOM 7595 N ASN C 225 4.327 -23.107 62.081 1.00 6.60 N

ATOM 7596 CA ASN C 225 5.086 -21.861 62.147 1.00 6.59 C

ATOM 7597 CB ASN C 225 5.236 -21.277 60.734 1.00 6.38 C

ATOM 7598 CG ASN C 225 5.868 -19.895 60.726 1.00 6.39 C

ATOM 7599 ODl ASN C 225 5.658 -19.086 61.634 1.00 4.69 O

ATOM 7600 ND2 ASN C 225 6.632 -19.612 59.679 1.00 5.73 N

ATOM 7601 C ASN C 225 6.455 -22.035 62.808 1.00 6.82 C

ATOM 7602 O ASN C 225 6.834 -21.250 63.693 1.00 6.66 O W2025-7029WO / AM102903-PCT

ATOM 7603 N SER C 226 -7.179 -23.071 62.380 1.00 7.05 N

ATOM 7604 CA SER C 226 -8.552 -23.316 62.823 1.00 7.37 C

ATOM 7605 CB SER C 226 -9.527 -22.620 61.858 1.00 7.74 C

ATOM 7606 OG SER C 226 10.882 -22.760 62.261 1.00 8.01 O

ATOM 7607 C SER C 226 -8.848 -24.829 62.927 1.00 7.63 C

ATOM 7608 O SER C 226 -9.706 -25.350 62.210 1.00 7.52 O

ATOM 7609 N PRO C 227 -8.139 -25.541 63.827 1.00 7.81 N

ATOM 7610 CA PRO C 227 -8.377 -26.980 63.943 1.00 8.07 C

ATOM 7611 CB PRO C 227 -7.256 -27.442 64.874 1.00 7.82 C

ATOM 7612 CG PRO C 227 -6.933 -26.244 65.695 1.00 7.88 C

ATOM 7613 CD PRO C 227 -7.118 -25.072 64.789 1.00 7.45 C

ATOM 7614 C PRO C 227 -9.740 -27.257 64.575 1.00 8.42 C

ATOM 7615 O PRO C 227 10.110 -26.587 65.539 1.00 7.98 O

ATOM 7616 N LEU C 228 10.485 -28.213 64.017 1.00 8.96 N

ATOM 7617 CA LEU C 228 11.788 -28.591 64.571 1.00 9.34 C

ATOM 7618 CB LEU C 228 12.547 -29.532 63.619 1.00 9.38 C

ATOM 7619 CG LEU C 228 13.942 -30.054 64.020 1.00 9.26 C

ATOM 7620 CDl LEU C 228 14.857 -28.950 64.523 1.00 9.09 C

ATOM 7621 CD2 LEU C 228 14.593 -30.787 62.850 1.00 9.18 C

ATOM 7622 C LEU C 228 11.669 -29.203 65.972 1.00 9.80 C

ATOM 7623 O LEU C 228 12.426 -28.845 66.877 1.00 9.57 O

ATOM 7624 N TYR C 229 10.708 -30.109 66.141 1.00 10.43 N

ATOM 7625 CA TYR C 229 10.462 -30.760 67.424 1.00 10.98 C

ATOM 7626 CB TYR C 229 10.712 -32.275 67.329 1.00 11.02 C

ATOM 7627 CG TYR C 229 12.056 -32.670 66.767 1.00 11.12 C

ATOM 7628 CDl TYR C 229 13.232 -32.420 67.478 1.00 11.68 C

ATOM 7629 CEl TYR C 229 14.475 -32.785 66.965 1.00 10.93 C

ATOM 7630 CZ TYR C 229 14.545 -33.426 65.740 1.00 11.32 C

ATOM 7631 OH TYR C 229 15.771 -33.792 65.239 1.00 10.92 O

ATOM 7632 CE2 TYR C 229 13.390 -33.694 65.017 1.00 10.63 C

ATOM 7633 CD2 TYR C 229 12.155 -33.323 65.535 1.00 11.07 C

ATOM 7634 C TYR C 229 -9.027 -30.516 67.884 1.00 11.43 C

ATOM 7635 O TYR C 229 -8.181 -30.045 67.111 1.00 11.41 O

ATOM 7636 N LYS C 230 -8.768 -30.843 69.147 1.00 11.67 N

ATOM 7637 CA LYS C 230 -7.438 -30.731 69.734 1.00 12.40 C

ATOM 7638 CB LYS C 230 -7.505 -30.896 71.260 1.00 12.26 C

ATOM 7639 CG LYS C 230 -7.841 -32.311 71.743 1.00 13.86 C

ATOM 7640 CD LYS C 230 -7.390 -32.519 73.184 1.00 15.14 C

ATOM 7641 CE LYS C 230 -7.272 -33.992 73.512 1.00 16.71 C

ATOM 7642 NZ LYS C 230 -6.085 -34.266 74.376 1.00 17.29 N

ATOM 7643 C LYS C 230 -6.465 -31.748 69.138 1.00 12.51 C

ATOM 7644 O LYS C 230 -6.876 -32.777 68.597 1.00 12.26 O

ATOM 7645 N TYR C 231 -5.177 -31.438 69.233 1.00 13.02 N

ATOM 7646 CA TYR C 231 -4.124 -32.383 68.891 1.00 13.60 C

ATOM 7647 CB TYR C 231 -2.840 -31.635 68.527 1.00 13.77 C

ATOM 7648 CG TYR C 231 -1.837 -32.490 67.793 1.00 13.79 C

ATOM 7649 CDl TYR C 231 -2.068 -32.895 66.476 1.00 13.56 C

ATOM 7650 CEl TYR C 231 -1.152 -33.692 65.800 1.00 13.71 C

ATOM 7651 CZ TYR C 231 0.010 -34.090 66.440 1.00 13.72 C

ATOM 7652 OH TYR C 231 0.923 -34.878 65.776 1.00 14.25 O

ATOM 7653 CE2 TYR C 231 0.263 -33.699 67.746 1.00 14.25 C

ATOM 7654 CD2 TYR C 231 -0.661 -32.903 68.414 1.00 13.87 C

ATOM 7655 C TYR C 231 -3.900 -33.297 70.096 1.00 14.15 C

ATOM 7656 O TYR C 231 -4.028 -32.838 71.232 1.00 13.97 O

ATOM 7657 N PRO C 232 -3.586 -34.595 69.861 1.00 14.78 N

ATOM 7658 CA PRO C 232 -3.420 -35.549 70.966 1.00 15.48 C

ATOM 7659 CB PRO C 232 -2.840 -36.789 70.275 1.00 15.42 C

ATOM 7660 CG PRO C 232 -3.376 -36.731 68.919 1.00 15.04 C

ATOM 7661 CD PRO C 232 -3.395 -35.262 68.559 1.00 14.79 C

ATOM 7662 C PRO C 232 -2.495 -35.079 72.089 1.00 16.05 C

ATOM 7663 O PRO C 232 -2.754 -35.389 73.252 1.00 16.46 O

ATOM 7664 N THR C 233 -1.450 -34.326 71.747 1.00 16.83 N

ATOM 7665 CA THR C 233 -0.503 -33.812 72.749 1.00 17.43 C W2025-7029WO / AM102903-PCT

ATOM 7666 CB THR C 233 0.949 -33.697 72.197 1.00 17.54 C

ATOM 7667 OGl THR C 233 1.003 -32.735 71.136 1.00 18.46 O

ATOM 7668 CG2 THR C 233 1.461 -35.043 71.697 1.00 18.02 C

ATOM 7669 C THR C 233 0.920 -32.483 73.404 1.00 17.70 C

ATOM 7670 O THR C 233 0.190 -31.956 74.255 1.00 18.01 O

ATOM 7671 N ASP C 234 2.081 -31.944 73.018 1.00 17.53 N

ATOM 7672 CA ASP C 234 2.606 -30.722 73.643 1.00 17.25 C

ATOM 7673 CB ASP C 234 3.758 -30.108 72.834 1.00 16.98 C

ATOM 7674 CG ASP C 234 3.309 -29.531 71.499 1.00 16.65 C

ATOM 7675 ODl ASP C 234 4.186 -29.253 70.658 1.00 15.34 O

ATOM 7676 OD2 ASP C 234 2.094 -29.350 71.283 1.00 16.04 O

ATOM 7677 C ASP C 234 3.068 -31.006 75.068 1.00 17.18 C

ATOM 7678 O ASP C 234 3.922 -31.869 75.297 1.00 17.33 O

ATOM 7679 N THR C 235 2.483 -30.279 76.017 1.00 16.99 N

ATOM 7680 CA THR C 235 2.811 -30.407 77.438 1.00 16.97 C

ATOM 7681 CB THR C 235 1.661 -31.076 78.216 1.00 17.06 C

ATOM 7682 OGl THR C 235 0.409 -30.531 77.777 1.00 17.99 O

ATOM 7683 CG2 THR C 235 1.655 -32.584 77.983 1.00 17.67 C

ATOM 7684 C THR C 235 3.076 -29.031 78.045 1.00 16.52 C

ATOM 7685 O THR C 235 2.608 -28.016 77.524 1.00 16.27 O

ATOM 7686 N GLY C 236 3.822 -29.004 79.151 1.00 16.30 N

ATOM 7687 CA GLY C 236 4.115 -27.761 79.863 1.00 15.94 C

ATOM 7688 C GLY C 236 4.872 -26.771 78.997 1.00 15.44 C

ATOM 7689 O GLY C 236 5.826 -27.145 78.321 1.00 15.35 O

ATOM 7690 N SER C 237 4.432 -25.513 79.012 1.00 15.02 N

ATOM 7691 CA SER C 237 5.066 -24.449 78.233 1.00 14.60 C

ATOM 7692 CB SER C 237 4.559 -23.073 78.672 1.00 14.84 C

ATOM 7693 OG SER C 237 3.148 -22.987 78.574 1.00 15.18 O

ATOM 7694 C SER C 237 4.906 -24.631 76.717 1.00 14.21 C

ATOM 7695 O SER C 237 5.770 -24.197 75.950 1.00 14.05 O

ATOM 7696 N ASN C 238 3.812 -25.273 76.298 1.00 13.57 N

ATOM 7697 CA ASN C 238 3.611 -25.651 74.893 1.00 13.03 C

ATOM 7698 CB ASN C 238 2.278 -26.385 74.699 1.00 13.10 C

ATOM 7699 CG ASN C 238 1.071 -25.458 74.783 1.00 13.64 C

ATOM 7700 ODl ASN C 238 1.152 -24.271 74.462 1.00 13.98 O

ATOM 7701 ND2 ASN C 238 0.064 -26.008 75.199 1.00 13.99 N

ATOM 7702 C ASN C 238 4.750 -26.502 74.337 1.00 12.69 C

ATOM 7703 O ASN C 238 4.995 -26.505 73.128 1.00 12.78 O

ATOM 7704 N ALA C 239 5.447 -27.215 75.221 1.00 12.31 N

ATOM 7705 CA ALA C 239 6.591 -28.041 74.829 1.00 12.05 C

ATOM 7706 CB ALA C 239 6.862 -29.121 75.874 1.00 12.16 C

ATOM 7707 C ALA C 239 7.863 -27.225 74.537 1.00 11.64 C

ATOM 7708 O ALA C 239 8.891 -27.785 74.147 1.00 11.45 O

ATOM 7709 N TYR C 240 7.784 -25.909 74.715 1.00 11.32 N

ATOM 7710 CA TYR C 240 8.912 -25.019 74.433 1.00 11.05 C

ATOM 7711 CB TYR C 240 8.981 -23.869 75.458 1.00 11.71 C

ATOM 7712 CG TYR C 240 8.993 -24.286 76.924 1.00 12.67 C

ATOM 7713 CDl TYR C 240 9.435 -25.552 77.316 1.00 13.08 C

ATOM 7714 CEl TYR C 240 9.452 -25.930 78.661 1.00 13.76 C

ATOM 7715 CZ TYR C 240 9.036 -25.026 79.630 1.00 13.90 C

ATOM 7716 OH TYR C 240 9.056 -25.396 80.954 1.00 14.20 O

ATOM 7717 CE2 TYR C 240 8.604 -23.757 79.269 1.00 13.79 C

ATOM 7718 CD2 TYR C 240 8.588 -23.393 77.920 1.00 13.05 C

ATOM 7719 C TYR C 240 8.847 -24.440 73.018 1.00 10.24 C

ATOM 7720 O TYR C 240 9.814 -23.839 72.547 1.00 9.95 O

ATOM 7721 N LEU C 241 7.710 -24.635 72.348 1.00 9.23 N

ATOM 7722 CA LEU C 241 7.419 -23.981 71.068 1.00 8.53 C

ATOM 7723 CB LEU C 241 5.914 -23.690 70.946 1.00 8.51 C

ATOM 7724 CG LEU C 241 5.230 -22.841 72.031 1.00 8.04 C

ATOM 7725 CDl LEU C 241 3.712 -22.929 71.907 1.00 8.32 C

ATOM 7726 CD2 LEU C 241 5.682 -21.388 71.978 1.00 8.27 C

ATOM 7727 C LEU C 241 7.922 -24.759 69.845 1.00 8.31 C

ATOM 7728 O LEU C 241 7.150 -25.114 68.947 1.00 7.87 O W2025-7029WO / AM102903-PCT

ATOM 7729 N ASN C 242 -9.226 -25.015 69.821 1.00 8.01 N

ATOM 7730 CA ASN C 242 -9.864 -25.694 68.699 1.00 7.94 C

ATOM 7731 CB ASN C 242 -9.724 -27.221 68.827 1.00 7.66 C

ATOM 7732 CG ASN C 242 10.302 -27.757 70.116 1.00 7.75 C

ATOM 7733 ODl ASN C 242 11.496 -28.049 70.202 1.00 7.60 O

ATOM 7734 ND2 ASN C 242 -9.456 -27.886 71.135 1.00 7.43 N

ATOM 7735 C ASN C 242 11.324 -25.273 68.573 1.00 8.00 C

ATOM 7736 O ASN C 242 11.914 -24.794 69.538 1.00 7.59 O

ATOM 7737 N VAL C 243 11.895 -25.460 67.385 1.00 8.14 N

ATOM 7738 CA VAL C 243 13.256 -24.998 67.085 1.00 8.37 C

ATOM 7739 CB VAL C 243 13.633 -25.235 65.596 1.00 8.38 C

ATOM 7740 CGl VAL C 243 15.076 -24.839 65.333 1.00 7.84 C

ATOM 7741 CG2 VAL C 243 12.695 -24.454 64.670 1.00 8.42 C

ATOM 7742 C VAL C 243 14.301 -25.624 68.017 1.00 8.61 C

ATOM 7743 O VAL C 243 15.164 -24.918 68.546 1.00 8.65 O

ATOM 7744 N ASP C 244 14.200 -26.937 68.228 1.00 9.18 N

ATOM 7745 CA ASP C 244 15.130 -27.671 69.092 1.00 9.41 C

ATOM 7746 CB ASP C 244 14.805 -29.169 69.102 1.00 10.02 C

ATOM 7747 CG ASP C 244 15.773 -29.975 69.956 1.00 11.38 C

ATOM 7748 ODl ASP C 244 16.852 -30.343 69.463 1.00 14.71 O

ATOM 7749 OD2 ASP C 244 15.450 -30.251 71.118 1.00 13.30 O

ATOM 7750 C ASP C 244 15.184 -27.111 70.519 1.00 9.28 C

ATOM 7751 O ASP C 244 16.275 -26.814 71.025 1.00 8.72 O

ATOM 7752 N TYR C 245 14.021 -26.944 71.155 1.00 8.96 N

ATOM 7753 CA TYR C 245 13.990 -26.405 72.521 1.00 9.25 C

ATOM 7754 CB TYR C 245 12.584 -26.423 73.150 1.00 9.71 C

ATOM 7755 CG TYR C 245 12.641 -26.179 74.650 1.00 10.81 C

ATOM 7756 CDl TYR C 245 12.766 -27.244 75.543 1.00 11.41 C

ATOM 7757 CEl TYR C 245 12.842 -27.028 76.915 1.00 11.99 C

ATOM 7758 CZ TYR C 245 12.809 -25.730 77.405 1.00 11.56 C

ATOM 7759 OH TYR C 245 12.888 -25.509 78.759 1.00 12.04 O

ATOM 7760 CE2 TYR C 245 12.698 -24.655 76.541 1.00 11.41 C

ATOM 7761 CD2 TYR C 245 12.616 -24.883 75.171 1.00 10.97 C

ATOM 7762 C TYR C 245 14.582 -24.998 72.616 1.00 8.80 C

ATOM 7763 O TYR C 245 15.408 -24.727 73.491 1.00 8.68 O

ATOM 7764 N VAL C 246 14.154 -24.119 71.715 1.00 8.06 N

ATOM 7765 CA VAL C 246 14.561 -22.716 71.732 1.00 7.64 C

ATOM 7766 CB VAL C 246 13.837 -21.907 70.632 1.00 7.45 C

ATOM 7767 CGl VAL C 246 14.409 -20.502 70.527 1.00 7.59 C

ATOM 7768 CG2 VAL C 246 12.346 -21.852 70.910 1.00 7.23 C

ATOM 7769 C VAL C 246 16.073 -22.556 71.581 1.00 7.52 C

ATOM 7770 O VAL C 246 16.710 -21.867 72.387 1.00 7.18 O

ATOM 7771 N MET C 247 16.633 -23.194 70.554 1.00 7.19 N

ATOM 7772 CA MET C 247 18.061 -23.099 70.272 1.00 7.54 C

ATOM 7773 CB MET C 247 18.419 -23.816 68.964 1.00 7.54 C

ATOM 7774 CG MET C 247 17.880 -23.144 67.691 1.00 7.47 C

ATOM 7775 SD MET C 247 18.081 -21.352 67.604 1.00 6.39 S

ATOM 7776 CE MET C 247 19.865 -21.187 67.638 1.00 6.09 C

ATOM 7777 C MET C 247 18.903 -23.641 71.418 1.00 7.79 C

ATOM HlS, O MET C 247 19.928 -23.060 71.766 1.00 7.75 O

ATOM 1119 N ASN C 248 18.465 -24.756 71.998 1.00 8.13 N

ATOM 7780 CA ASN C 248 19.150 -25.335 73.147 1.00 8.86 C

ATOM 7781 CB ASN C 248 18.728 -26.796 73.374 1.00 9.01 C

ATOM 7782 CG ASN C 248 19.405 -27.754 72.404 1.00 9.91 C

ATOM 7783 ODl ASN C 248 20.620 -27.964 72.464 1.00 11.69 O

ATOM 7784 ND2 ASN C 248 18.623 -28.336 71.500 1.00 9.36 N

ATOM 7785 C ASN C 248 19.013 -24.502 74.416 1.00 8.64 C

ATOM 7786 O ASN C 248 19.926 -24.485 75.235 1.00 9.19 O

ATOM 7787 N TYR C 249 17.901 -23.784 74.566 1.00 8.55 N

ATOM 7788 CA TYR C 249 17.748 -22.866 75.698 1.00 8.35 C

ATOM 7789 CB TYR C 249 16.345 -22.238 75.760 1.00 8.53 C

ATOM 7790 CG TYR C 249 16.141 -21.443 77.033 1.00 8.66 C

ATOM 7791 CDl TYR C 249 15.592 -22.038 78.168 1.00 8.29 C W2025-7029WO / AM102903-PCT

ATOM 7792 CEl TYR C 249 15.425 -21.319 79.348 1.00 8.81 C

ATOM 7793 CZ TYR C 249 15.813 -19.992 79.400 1.00 9.13 C

ATOM 7794 OH TYR C 249 15.657 -19.276 80.561 1.00 9.55 O

ATOM 7795 CE2 TYR C 249 16.370 -19.378 78.291 1.00 9.37 C

ATOM 7796 CD2 TYR C 249 16.532 -20.103 77.115 1.00 8.70 C

ATOM 7797 C TYR C 249 18.815 -21.771 75.679 1.00 8.23 C

ATOM 7798 O TYR C 249 19.438 -21.488 76.712 1.00 7.58 O

ATOM 7799 N TRP C 250 19.015 -21.158 74.508 1.00 7.82 N

ATOM 7800 CA TRP C 250 20.029 -20.113 74.339 1.00 7.98 C

ATOM 7801 CB TRP C 250 19.959 -19.505 72.935 1.00 7.43 C

ATOM 7802 CG TRP C 250 18.934 -18.431 72.816 1.00 7.03 C

ATOM 7803 CDl TRP C 250 17.630 -18.577 72.429 1.00 6.36 C

ATOM 7804 NEl TRP C 250 16.996 -17.359 72.444 1.00 6.19 N

ATOM 7805 CE2 TRP C 250 17.883 -16.400 72.858 1.00 6.09 C

ATOM 7806 CD2 TRP C 250 19.117 -17.039 73.096 1.00 5.66 C

ATOM 7807 CE3 TRP C 250 20.207 -16.270 73.527 1.00 5.37 C

ATOM 7808 CZ3 TRP C 250 20.034 -14.909 73.695 1.00 6.27 C

ATOM 7809 CH2 TRP C 250 18.789 -14.299 73.454 1.00 6.63 C

ATOM 7810 CZ2 TRP C 250 17.705 -15.028 73.038 1.00 6.36 C

ATOM 7811 C TRP C 250 21.425 -20.652 74.612 1.00 8.38 C

ATOM 7812 O TRP C 250 22.221 -20.014 75.305 1.00 8.75 O

ATOM 7813 N LYS C 251 21.704 -21.834 74.068 1.00 8.99 N

ATOM 7814 CA LYS C 251 22.989 -22.510 74.229 1.00 9.75 C

ATOM 7815 CB LYS C 251 22.968 -23.783 73.381 1.00 9.78 C

ATOM 7816 CG LYS C 251 24.295 -24.458 73.103 1.00 11.46 C

ATOM 7817 CD LYS C 251 24.030 -25.736 72.287 1.00 11.48 C

ATOM 7818 CE LYS C 251 25.301 -26.527 72.005 1.00 14.70 C

ATOM 7819 NZ LYS C 251 25.088 -27.515 70.900 1.00 15.74 N

ATOM 7820 C LYS C 251 23.273 -22.819 75.715 1.00 9.49 C

ATOM 7821 O LYS C 251 24.341 -22.462 76.240 1.00 9.12 O

ATOM 7822 N ASP C 252 22.303 -23.444 76.392 1.00 8.81 N

ATOM 7823 CA ASP C 252 22.452 -23.846 77.797 1.00 8.84 C

ATOM 7824 CB ASP C 252 21.266 -24.708 78.250 1.00 8.77 C

ATOM 7825 CG ASP C 252 21.194 -26.049 77.536 1.00 8.84 C

ATOM 7826 ODl ASP C 252 22.139 -26.410 76.803 1.00 8.01 O

ATOM 7827 OD2 ASP C 252 20.173 -26.749 77.716 1.00 10.37 O

ATOM 7828 C ASP C 252 22.589 -22.673 78.759 1.00 8.86 C

ATOM 7829 O ASP C 252 23.180 -22.809 79.838 1.00 8.73 O

ATOM 7830 N ASN C 253 22.039 -21.527 78.367 1.00 8.53 N

ATOM 7831 CA ASN C 253 22.015 -20.348 79.229 1.00 8.83 C

ATOM 7832 CB ASN C 253 20.589 -19.800 79.330 1.00 8.60 C

ATOM 7833 CG ASN C 253 19.675 -20.740 80.085 1.00 8.93 C

ATOM 7834 ODl ASN C 253 19.596 -20.687 81.311 1.00 8.53 O

ATOM 7835 ND2 ASN C 253 18.986 -21.618 79.357 1.00 8.18 N

ATOM 7836 C ASN C 253 23.033 -19.249 78.904 1.00 8.70 C

ATOM 7837 O ASN C 253 22.915 -18.133 79.407 1.00 8.93 O

ATOM 7838 N GLY C 254 24.027 -19.568 78.073 1.00 8.66 N

ATOM 7839 CA GLY C 254 25.210 -18.721 77.944 1.00 8.89 C

ATOM 7840 C GLY C 254 25.687 -18.242 76.580 1.00 9.07 C

ATOM 7841 O GLY C 254 26.734 -17.599 76.498 1.00 9.12 O

ATOM 7842 N ALA C 255 24.937 -18.535 75.516 1.00 8.73 N

ATOM 7843 CA ALA C 255 25.311 -18.074 74.179 1.00 8.68 C

ATOM 7844 CB ALA C 255 24.061 -17.712 73.361 1.00 8.36 C

ATOM 7845 C ALA C 255 26.141 -19.130 73.451 1.00 8.57 C

ATOM 7846 O ALA C 255 25.674 -20.256 73.271 1.00 8.12 O

ATOM 7847 N PRO C 256 27.372 -18.769 73.023 1.00 8.72 N

ATOM 7848 CA PRO C 256 28.218 -19.703 72.266 1.00 8.57 C

ATOM 7849 CB PRO C 256 29.411 -18.835 71.845 1.00 8.60 C

ATOM 7850 CG PRO C 256 29.467 -17.742 72.841 1.00 8.82 C

ATOM 7851 CD PRO C 256 28.036 -17.466 73.223 1.00 8.66 C

ATOM 7852 C PRO C 256 27.497 -20.240 71.031 1.00 8.49 C

ATOM 7853 O PRO C 256 26.891 -19.465 70.286 1.00 8.36 O

ATOM 7854 N ALA C 257 27.556 -21.553 70.820 1.00 8.66 N W2025-7029WO / AM102903-PCT

ATOM 7855 CA ALA C 257 26.871 -22.190 69.681 1.00 8.64 C

ATOM 7856 CB ALA C 257 27.132 -23.702 69.667 1.00 8.81 C

ATOM 7857 C ALA C 257 27.237 -21.564 68.329 1.00 8.65 C

ATOM 7858 O ALA C 257 26.381 -21.412 67.459 1.00 8.44 O

ATOM 7859 N GLU C 258 28.505 -21.186 68.171 1.00 8.80 N

ATOM 7860 CA GLU C 258 29.006 -20.611 66.919 1.00 9.18 C

ATOM 7861 CB GLU C 258 30.540 -20.548 66.937 1.00 9.39 C

ATOM 7862 CG GLU C 258 31.189 -20.134 65.610 1.00 11.40 C

ATOM 7863 CD GLU C 258 31.025 -21.176 64.499 1.00 14.20 C

ATOM 7864 OEl GLU C 258 30.778 -22.367 64.807 1.00 15.37 O

ATOM 7865 OE2 GLU C 258 31.164 -20.795 63.314 1.00 14.58 O

ATOM 7866 C GLU C 258 28.425 -19.229 66.602 1.00 8.75 C

ATOM 7867 O GLU C 258 28.344 -18.837 65.433 1.00 8.86 O

ATOM 7868 N LYS C 259 28.030 -18.492 67.636 1.00 8.14 N

ATOM 7869 CA LYS C 259 27.404 -17.189 67.435 1.00 7.82 C

ATOM 7870 CB LYS C 259 27.688 -16.262 68.619 1.00 7.61 C

ATOM 7871 CG LYS C 259 29.136 -15.754 68.679 1.00 7.66 C

ATOM 7872 CD LYS C 259 29.276 -14.652 69.715 1.00 7.11 C

ATOM 7873 CE LYS C 259 30.703 -14.135 69.797 1.00 6.70 C

ATOM 7874 NZ LYS C 259 30.801 -13.015 70.770 1.00 6.09 N

ATOM 7875 C LYS C 259 25.895 -17.303 67.191 1.00 7.65 C

ATOM 7876 O LYS C 259 25.264 -16.341 66.732 1.00 7.56 O

ATOM 7877 N LEU C 260 25.325 -18.469 67.504 1.00 7.35 N

ATOM 7878 CA LEU C 260 23.877 -18.679 67.388 1.00 7.34 C

ATOM 7879 CB LEU C 260 23.381 -19.734 68.385 1.00 7.31 C

ATOM 7880 CG LEU C 260 23.293 -19.337 69.864 1.00 7.36 C

ATOM 7881 CDl LEU C 260 23.167 -20.574 70.746 1.00 7.17 C

ATOM 7882 CD2 LEU C 260 22.134 -18.358 70.116 1.00 5.76 C

ATOM 7883 C LEU C 260 23.482 -19.058 65.966 1.00 7.49 C

ATOM 7884 O LEU C 260 24.022 -20.010 65.386 1.00 7.52 O

ATOM 7885 N ILE C 261 22.521 -18.310 65.428 1.00 7.09 N

ATOM 7886 CA ILE C 261 22.091 -18.441 64.045 1.00 7.12 C

ATOM 7887 CB ILE C 261 22.351 -17.104 63.260 1.00 7.08 C

ATOM 7888 CGl ILE C 261 23.826 -16.668 63.337 1.00 6.94 C

ATOM 7889 CDl ILE C 261 24.837 -17.636 62.692 1.00 6.89 C

ATOM 7890 CG2 ILE C 261 21.878 -17.194 61.819 1.00 6.90 C

ATOM 7891 C ILE C 261 20.601 -18.802 64.044 1.00 7.12 C

ATOM 7892 O ILE C 261 19.778 -18.057 64.577 1.00 7.07 O

ATOM 7893 N VAL C 262 20.270 -19.952 63.461 1.00 6.95 N

ATOM 7894 CA VAL C 262 18.902 -20.490 63.491 1.00 7.23 C

ATOM 7895 CB VAL C 262 18.873 -22.023 63.203 1.00 7.25 C

ATOM 7896 CGl VAL C 262 17.440 -22.588 63.307 1.00 6.81 C

ATOM 7897 CG2 VAL C 262 19.810 -22.778 64.144 1.00 7.00 C

ATOM 7898 C VAL C 262 17.992 -19.769 62.492 1.00 7.31 C

ATOM 7899 O VAL C 262 18.339 -19.615 61.324 1.00 7.22 O

ATOM 7900 N GLY C 263 16.823 -19.344 62.964 1.00 7.37 N

ATOM 7901 CA GLY C 263 15.844 -18.663 62.123 1.00 7.48 C

ATOM 7902 C GLY C 263 15.021 -19.593 61.248 1.00 7.70 C

ATOM 7903 O GLY C 263 14.386 -20.535 61.739 1.00 7.52 O

ATOM 7904 N PHE C 264 15.027 -19.306 59.948 1.00 7.65 N

ATOM 7905 CA PHE C 264 14.301 -20.086 58.945 1.00 7.80 C

ATOM 7906 CB PHE C 264 15.268 -20.619 57.870 1.00 8.10 C

ATOM 7907 CG PHE C 264 16.014 -21.866 58.268 1.00 8.40 C

ATOM 7908 CDl PHE C 264 17.054 -21.811 59.196 1.00 8.14 C

ATOM 7909 CEl PHE C 264 17.753 -22.962 59.553 1.00 8.80 C

ATOM 7910 CZ PHE C 264 17.418 -24.187 58.972 1.00 8.74 C

ATOM 7911 CE2 PHE C 264 16.389 -24.250 58.037 1.00 8.69 C

ATOM 7912 CD2 PHE C 264 15.695 -23.093 57.688 1.00 8.22 C

ATOM 7913 C PHE C 264 13.276 -19.179 58.275 1.00 7.66 C

ATOM 7914 O PHE C 264 13.653 -18.153 57.697 1.00 7.65 O

ATOM 7915 N PRO C 265 11.978 -19.534 58.365 1.00 7.51 N

ATOM 7916 CA PRO C 265 10.915 -18.763 57.706 1.00 7.57 C

ATOM 7917 CB PRO C 265 -9.718 -19.002 58.621 1.00 7.31 C W2025-7029WO / AM102903-PCT

ATOM 7918 CG PRO C 265 -9.945 -20.386 59.162 1.00 7.68 C

ATOM 7919 CD PRO C 265 11.428 -20.656 59.150 1.00 7.31 C

ATOM 7920 C PRO C 265 10.568 -19.211 56.275 1.00 7.54 C

ATOM 7921 O PRO C 265 10.288 -20.396 56.043 1.00 8.00 O

ATOM 7922 N THR C 266 10.569 -18.265 55.335 1.00 7.47 N

ATOM 7923 CA THR C 266 10.123 -18.526 53.963 1.00 7.39 C

ATOM 7924 CB THR C 266 11.038 -17.854 52.916 1.00 7.45 C

ATOM 7925 OGl THR C 266 11.203 -16.467 53.237 1.00 8.14 O

ATOM 7926 CG2 THR C 266 12.400 -18.541 52.875 1.00 7.28 C

ATOM 7927 C THR C 266 -8.653 -18.123 53.745 1.00 7.23 C

ATOM 7928 O THR C 266 -8.268 -17.631 52.679 1.00 6.82 O

ATOM 7929 N TYR C 267 -7.846 -18.353 54.775 1.00 6.90 N

ATOM 7930 CA TYR C 267 -6.417 -18.060 54.762 1.00 6.95 C

ATOM 7931 CB TYR C 267 -6.173 -16.618 55.213 1.00 7.00 C

ATOM 7932 CG TYR C 267 -6.512 -16.408 56.672 1.00 7.03 C

ATOM 7933 CDl TYR C 267 -5.535 -16.554 57.663 1.00 7.38 C

ATOM 7934 CEl TYR C 267 -5.846 -16.383 59.012 1.00 7.04 C

ATOM 7935 CZ TYR C 267 -7.150 -16.069 59.374 1.00 7.23 C

ATOM 7936 OH TYR C 267 -7.465 -15.893 60.700 1.00 7.21 O

ATOM 7937 CE2 TYR C 267 -8.138 -15.925 58.409 1.00 7.29 C

ATOM 7938 CD2 TYR C 267 -7.817 -16.105 57.067 1.00 6.35 C

ATOM 7939 C TYR C 267 -5.740 -19.012 55.742 1.00 7.10 C

ATOM 7940 O TYR C 267 -6.421 -19.657 56.548 1.00 6.83 O

ATOM 7941 N GLY C 268 -4.408 -19.080 55.683 1.00 7.37 N

ATOM 7942 CA GLY C 268 -3.615 -19.845 56.644 1.00 7.82 C

ATOM 7943 C GLY C 268 -2.497 -19.036 57.292 1.00 8.19 C

ATOM 7944 O GLY C 268 -2.210 -17.914 56.872 1.00 8.07 O

ATOM 7945 N HIS C 269 -1.889 -19.596 58.339 1.00 8.27 N

ATOM 7946 CA HIS C 269 -0.705 -18.997 58.964 1.00 8.58 C

ATOM 7947 CB HIS C 269 -0.808 -18.984 60.493 1.00 8.49 C

ATOM 7948 CG HIS C 269 -1.656 -17.878 61.036 1.00 9.15 C

ATOM 7949 NDl HIS C 269 -1.266 -16.556 61.007 1.00 10.08 N

ATOM 7950 CEl HIS C 269 -2.207 -15.810 61.558 1.00 9.22 C

ATOM 7951 NE2 HIS C 269 -3.195 -16.599 61.940 1.00 8.51 N

ATOM 7952 CD2 HIS C 269 -2.874 -17.898 61.627 1.00 9.07 C

ATOM 7953 C HIS C 269 0.519 -19.794 58.573 1.00 8.79 C

ATOM 7954 O HIS C 269 0.493 -21.022 58.617 1.00 8.73 O

ATOM 7955 N ASN C 270 1.587 -19.096 58.196 1.00 8.91 N

ATOM 7956 CA ASN C 270 2.837 -19.768 57.837 1.00 8.87 C

ATOM 7957 CB ASN C 270 3.224 -19.526 56.359 1.00 8.70 C

ATOM 7958 CG ASN C 270 3.432 -18.056 56.021 1.00 9.26 C

ATOM 7959 ODl ASN C 270 3.687 -17.232 56.892 1.00 8.23 O

ATOM 7960 ND2 ASN C 270 3.338 -17.729 54.735 1.00 9.32 N

ATOM 7961 C ASN C 270 3.994 -19.495 58.807 1.00 8.93 C

ATOM 7962 O ASN C 270 3.964 -18.534 59.588 1.00 9.03 O

ATOM 7963 N PHE C 271 4.996 -20.370 58.751 1.00 8.91 N

ATOM 7964 CA PHE C 271 6.078 -20.421 59.726 1.00 8.80 C

ATOM 7965 CB PHE C 271 5.869 -21.590 60.701 1.00 8.44 C

ATOM 7966 CG PHE C 271 4.555 -21.565 61.458 1.00 7.55 C

ATOM 7967 CDl PHE C 271 3.353 -21.863 60.824 1.00 7.23 C

ATOM 7968 CEl PHE C 271 2.148 -21.858 61.528 1.00 6.09 C

ATOM 7969 CZ PHE C 271 2.144 -21.586 62.887 1.00 6.66 C

ATOM 7970 CE2 PHE C 271 3.339 -21.317 63.536 1.00 6.80 C

ATOM 7971 CD2 PHE C 271 4.538 -21.309 62.818 1.00 6.63 C

ATOM 7972 C PHE C 271 7.396 -20.666 59.004 1.00 9.16 C

ATOM 7973 O PHE C 271 7.407 -21.219 57.902 1.00 8.83 O

ATOM 7974 N ILE C 272 8.500 -20.266 59.633 1.00 9.65 N

ATOM 7975 CA ILE C 272 9.825 -20.742 59.236 1.00 10.20 C

ATOM 7976 CB ILE C 272 10.890 -19.595 59.178 1.00 10.06 C

ATOM 7977 CGl ILE C 272 10.499 -18.514 58.161 1.00 9.72 C

ATOM 7978 CDl ILE C 272 10.355 -19.000 56.713 1.00 9.75 C

ATOM 7979 CG2 ILE C 272 12.290 -20.154 58.868 1.00 9.90 C

ATOM 7980 C ILE C 272 10.270 -21.837 60.209 1.00 10.70 C W2025-7029WO / AM102903-PCT

ATOM 7981 O ILE C 272 10.499 -21.571 61.385 1.00 10.57 O

ATOM 7982 N LEU C 273 10.382 -23.068 59.707 1.00 11.55 N

ATOM 7983 CA LEU C 273 10.808 -24.210 60.515 1.00 12.14 C

ATOM 7984 CB LEU C 273 10.684 -25.516 59.711 1.00 12.05 C

ATOM 7985 CG LEU C 273 9.308 -25.940 59.181 1.00 11.38 C

ATOM 7986 CDl LEU C 273 9.447 -27.009 58.098 1.00 10.95 C

ATOM 7987 CD2 LEU C 273 8.397 -26.414 60.313 1.00 10.72 C

ATOM 7988 C LEU C 273 12.248 -24.038 60.984 1.00 12.86 C

ATOM 7989 O LEU C 273 13.123 -23.654 60.197 1.00 12.98 O

ATOM 7990 N SER C 274 12.491 -24.326 62.260 1.00 13.52 N

ATOM 7991 CA SER C 274 13.845 -24.300 62.810 1.00 14.26 C

ATOM 7992 CB SER C 274 13.810 -24.409 64.332 1.00 14.28 C

ATOM 7993 OG SER C 274 13.035 -23.364 64.899 1.00 14.30 O

ATOM 7994 C SER C 274 14.680 -25.430 62.208 1.00 14.87 C

ATOM 7995 O SER C 274 15.881 -25.280 61.986 1.00 14.82 O

ATOM 7996 N ASN C 275 14.021 -26.552 61.935 1.00 15.88 N

ATOM 7997 CA ASN C 275 14.641 -27.700 61.282 1.00 16.73 C

ATOM 7998 CB ASN C 275 15.009 -28.767 62.322 1.00 17.11 C

ATOM 7999 CG ASN C 275 15.914 -29.861 61.762 1.00 18.54 C

ATOM 8000 ODl ASN C 275 15.958 -30.113 60.551 1.00 19.97 O

ATOM 8001 ND2 ASN C 275 16.640 -30.525 62.655 1.00 20.19 N

ATOM 8002 C ASN C 275 13.682 -28.271 60.243 1.00 16.65 C

ATOM 8003 O ASN C 275 12.640 -28.817 60.606 1.00 16.99 O

ATOM 8004 N PRO C 276 14.024 -28.137 58.948 1.00 16.71 N

ATOM 8005 CA PRO C 276 13.161 -28.586 57.846 1.00 16.59 C

ATOM 8006 CB PRO C 276 13.959 -28.205 56.590 1.00 16.55 C

ATOM 8007 CG PRO C 276 15.368 -28.067 57.050 1.00 16.90 C

ATOM 8008 CD PRO C 276 15.268 -27.523 58.446 1.00 16.80 C

ATOM 8009 C PRO C 276 12.856 -30.088 57.853 1.00 16.44 C

ATOM 8010 O PRO C 276 11.925 -30.526 57.175 1.00 16.23 O

ATOM 8011 N SER C 277 13.630 -30.861 58.615 1.00 16.34 N

ATOM 8012 CA SER C 277 13.413 -32.303 58.732 1.00 16.20 C

ATOM 8013 CB SER C 277 14.722 -33.022 59.088 1.00 16.39 C

ATOM 8014 OG SER C 277 15.016 -32.918 60.473 1.00 16.97 O

ATOM 8015 C SER C 277 12.300 -32.658 59.729 1.00 15.74 C

ATOM 8016 O SER C 277 11.862 -33.809 59.783 1.00 15.86 O

ATOM 8017 N ASN C 278 11.860 -31.677 60.517 1.00 15.37 N

ATOM 8018 CA ASN C 278 10.712 -31.836 61.413 1.00 15.17 C

ATOM 8019 CB ASN C 278 11.101 -31.548 62.869 1.00 15.34 C

ATOM 8020 CG ASN C 278 9.960 -31.812 63.856 1.00 16.39 C

ATOM 8021 ODl ASN C 278 8.876 -32.294 63.485 1.00 17.85 O

ATOM 8022 ND2 ASN C 278 10.201 -31.491 65.122 1.00 16.07 N

ATOM 8023 C ASN C 278 9.562 -30.936 60.965 1.00 14.85 C

ATOM 8024 O ASN C 278 9.645 -29.707 61.064 1.00 14.63 O

ATOM 8025 N THR C 279 8.495 -31.562 60.472 1.00 14.21 N

ATOM 8026 CA THR C 279 7.387 -30.846 59.835 1.00 13.58 C

ATOM 8027 CB THR C 279 7.312 -31.174 58.339 1.00 13.57 C

ATOM 8028 OGl THR C 279 7.135 -32.589 58.183 1.00 13.32 O

ATOM 8029 CG2 THR C 279 8.573 -30.719 57.618 1.00 13.35 C

ATOM 8030 C THR C 279 6.029 -31.191 60.435 1.00 13.14 C

ATOM 8031 O THR C 279 4.990 -30.927 59.827 1.00 13.23 O

ATOM 8032 N GLY C 280 6.037 -31.795 61.615 1.00 12.78 N

ATOM 8033 CA GLY C 280 4.798 -32.163 62.294 1.00 12.21 C

ATOM 8034 C GLY C 280 4.191 -31.008 63.064 1.00 11.87 C

ATOM 8035 O GLY C 280 4.731 -29.898 63.069 1.00 11.85 O

ATOM 8036 N ILE C 281 3.055 -31.271 63.703 1.00 11.30 N

ATOM 8037 CA ILE C 281 2.403 -30.293 64.566 1.00 11.03 C

ATOM 8038 CB ILE C 281 0.953 -30.721 64.910 1.00 10.78 C

ATOM 8039 CGl ILE C 281 0.083 -30.799 63.638 1.00 10.31 C

ATOM 8040 CDl ILE C 281 -0.187 -29.466 62.946 1.00 9.63 C

ATOM 8041 CG2 ILE C 281 0.339 -29.804 65.984 1.00 11.10 C

ATOM 8042 C ILE C 281 3.234 -30.117 65.844 1.00 11.02 C

ATOM 8043 O ILE C 281 3.570 -31.091 66.517 1.00 11.00 O W2025-7029WO / AM102903-PCT

ATOM 8044 N GLY C 282 3.582 -28.874 66.156 1.00 10.96 N

ATOM 8045 CA GLY C 282 4.392 -28.588 67.337 1.00 11.11 C

ATOM 8046 C GLY C 282 5.887 -28.586 67.076 1.00 11.00 C

ATOM 8047 O GLY C 282 6.677 -28.543 68.020 1.00 11.00 O

ATOM 8048 N ALA C 283 6.274 -28.624 65.800 1.00 11.06 N

ATOM 8049 CA ALA C 283 7.680 -28.507 65.399 1.00 11.22 C

ATOM 8050 CB ALA C 283 7.849 -28.882 63.926 1.00 11.15 C

ATOM 8051 C ALA C 283 8.216 -27.093 65.656 1.00 11.57 C

ATOM 8052 O ALA C 283 7.518 -26.103 65.386 1.00 11.27 O

ATOM 8053 N PRO C 284 9.456 -26.988 66.184 1.00 11.80 N

ATOM 8054 CA PRO C 284 10.041 -25.687 66.510 1.00 11.78 C

ATOM 8055 CB PRO C 284 11.444 -26.048 67.010 1.00 11.96 C

ATOM 8056 CG PRO C 284 11.322 -27.446 67.486 1.00 12.34 C

ATOM 8057 CD PRO C 284 10.377 -28.089 66.518 1.00 11.93 C

ATOM 8058 C PRO C 284 10.126 -24.757 65.304 1.00 11.58 C

ATOM 8059 O PRO C 284 10.495 -25.181 64.204 1.00 11.43 O

ATOM 8060 N THR C 285 9.757 -23.499 65.514 1.00 11.52 N

ATOM 8061 CA THR C 285 9.826 -22.491 64.461 1.00 11.46 C

ATOM 8062 CB THR C 285 8.421 -22.028 64.002 1.00 11.45 C

ATOM 8063 OGl THR C 285 7.721 -21.434 65.099 1.00 11.29 O

ATOM 8064 CG2 THR C 285 7.620 -23.209 63.481 1.00 11.27 C

ATOM 8065 C THR C 285 10.669 -21.301 64.903 1.00 11.52 C

ATOM 8066 O THR C 285 10.820 -21.046 66.099 1.00 11.44 O

ATOM 8067 N SER C 286 11.229 -20.588 63.930 1.00 11.74 N

ATOM 8068 CA SER C 286 12.105 -19.457 64.206 1.00 12.13 C

ATOM 8069 CB SER C 286 13.436 -19.609 63.454 1.00 12.19 C

ATOM 8070 OG SER C 286 13.237 -19.628 62.052 1.00 13.47 O

ATOM 8071 C SER C 286 11.441 -18.115 63.887 1.00 12.01 C

ATOM 8072 O SER C 286 12.031 -17.057 64.103 1.00 12.14 O

ATOM 8073 N GLY C 287 10.211 -18.158 63.383 1.00 11.86 N

ATOM 8074 CA GLY C 287 9.465 -16.933 63.105 1.00 11.67 C

ATOM 8075 C GLY C 287 8.393 -17.086 62.045 1.00 11.68 C

ATOM 8076 O GLY C 287 8.197 -18.174 61.496 1.00 11.32 O

ATOM 8077 N ALA C 288 7.691 -15.989 61.776 1.00 11.73 N

ATOM 8078 CA ALA C 288 6.656 -15.949 60.743 1.00 12.03 C

ATOM 8079 CB ALA C 288 6.014 -14.577 60.693 1.00 12.00 C

ATOM 8080 C ALA C 288 7.200 -16.318 59.368 1.00 12.22 C

ATOM 8081 O ALA C 288 8.316 -15.936 59.002 1.00 12.16 O

ATOM 8082 N GLY C 289 6.402 -17.062 58.611 1.00 12.22 N

ATOM 8083 CA GLY C 289 6.725 -17.347 57.225 1.00 12.50 C

ATOM 8084 C GLY C 289 6.546 -16.105 56.370 1.00 12.70 C

ATOM 8085 O GLY C 289 6.099 -15.063 56.866 1.00 12.87 O

ATOM 8086 N PRO C 290 6.874 -16.206 55.072 1.00 12.71 N

ATOM 8087 CA PRO C 290 6.886 -15.010 54.229 1.00 12.88 C

ATOM 8088 CB PRO C 290 7.680 -15.451 52.998 1.00 12.79 C

ATOM 8089 CG PRO C 290 7.520 -16.935 52.940 1.00 12.98 C

ATOM 8090 CD PRO C 290 7.232 -17.429 54.329 1.00 12.72 C

ATOM 8091 C PRO C 290 5.492 -14.517 53.833 1.00 12.97 C

ATOM 8092 O PRO C 290 4.589 -15.319 53.573 1.00 12.96 O

ATOM 8093 N ALA C 291 5.326 -13.199 53.806 1.00 13.22 N

ATOM 8094 CA ALA C 291 4.104 -12.590 53.298 1.00 13.42 C

ATOM 8095 CB ALA C 291 4.136 -11.094 53.525 1.00 13.38 C

ATOM 8096 C ALA C 291 3.958 -12.907 51.810 1.00 13.66 C

ATOM 8097 O ALA C 291 4.955 -13.006 51.092 1.00 13.69 O

ATOM 8098 N GLY C 292 2.719 -13.089 51.359 1.00 13.77 N

ATOM 8099 CA GLY C 292 2.437 -13.382 49.956 1.00 14.27 C

ATOM 8100 C GLY C 292 2.482 -12.140 49.080 1.00 14.67 C

ATOM 8101 O GLY C 292 2.397 -11.024 49.591 1.00 14.58 O

ATOM 8102 N PRO C 293 2.615 -12.323 47.750 1.00 15.08 N

ATOM 8103 CA PRO C 293 2.743 -11.184 46.834 1.00 15.43 C

ATOM 8104 CB PRO C 293 3.226 -11.835 45.532 1.00 15.71 C

ATOM 8105 CG PRO C 293 2.683 -13.217 45.581 1.00 15.40 C

ATOM 8106 CD PRO C 293 2.658 -13.614 47.035 1.00 15.14 C W2025-7029WO / AM102903-PCT

ATOM 8107 C PRO C 293 1.434 -10.420 46.608 1.00 15.68 C

ATOM 8108 O PRO C 293 1.456 -9.283 46.126 1.00 15.71 O

ATOM 8109 N TYR C 294 0.310 -11.033 46.966 1.00 15.91 N

ATOM 8110 CA TYR C 294 0.997 -10.394 46.785 1.00 16.21 C

ATOM 8111 CB TYR C 294 2.007 -11.380 46.192 1.00 16.15 C

ATOM 8112 CG TYR C 294 1.710 -11.768 44.759 1.00 16.16 C

ATOM 8113 CDl TYR C 294 1.143 -13.001 44.457 1.00 15.85 C

ATOM 8114 CEl TYR C 294 0.868 -13.366 43.140 1.00 16.27 C

ATOM 8115 CZ TYR C 294 1.162 -12.485 42.108 1.00 16.24 C

ATOM 8116 OH TYR C 294 0.888 -12.849 40.811 1.00 16.67 O

ATOM 8117 CE2 TYR C 294 1.724 -11.248 42.380 1.00 16.04 C

ATOM 8118 CD2 TYR C 294 1.996 -10.896 43.705 1.00 16.44 C

ATOM 8119 C TYR C 294 1.556 -9.739 48.053 1.00 16.34 C

ATOM 8120 O TYR C 294 1.941 -8.570 48.022 1.00 16.38 O

ATOM 8121 N ALA C 295 1.602 -10.485 49.157 1.00 16.40 N

ATOM 8122 CA ALA C 295 2.145 -9.960 50.416 1.00 16.52 C

ATOM 8123 CB ALA C 295 2.775 -11.081 51.247 1.00 16.39 C

ATOM 8124 C ALA C 295 1.096 -9.204 51.231 1.00 16.64 C

ATOM 8125 O ALA C 295 1.429 -8.269 51.956 1.00 16.56 O

ATOM 8126 N LYS C 296 0.165 -9.625 51.102 1.00 16.91 N

ATOM 8127 CA LYS C 296 1.321 -8.980 51.751 1.00 17.05 C

ATOM 8128 CB LYS C 296 1.619 -7.612 51.123 1.00 17.33 C

ATOM 8129 CG LYS C 296 1.909 -7.683 49.638 1.00 18.45 C

ATOM 8130 CD LYS C 296 2.495 -6.392 49.126 1.00 20.80 C

ATOM 8131 CE LYS C 296 2.604 -6.429 47.613 1.00 22.11 C

ATOM 8132 NZ LYS C 296 3.577 -5.407 47.162 1.00 23.84 N

ATOM 8133 C LYS C 296 1.226 -8.864 53.275 1.00 16.91 C

ATOM 8134 O LYS C 296 1.704 -7.892 53.869 1.00 17.07 O

ATOM 8135 N GLU C 297 0.631 -9.873 53.901 1.00 16.60 N

ATOM 8136 CA GLU C 297 0.519 -9.918 55.351 1.00 16.29 C

ATOM 8137 CB GLU C 297 0.921 -10.224 55.764 1.00 16.32 C

ATOM 8138 CG GLU C 297 1.902 -9.117 55.395 1.00 17.12 C

ATOM 8139 CD GLU C 297 3.355 -9.531 55.532 1.00 17.86 C

ATOM 8140 OEl GLU C 297 3.662 -10.383 56.386 1.00 18.25 O

ATOM 8141 OE2 GLU C 297 4.194 -8.997 54.784 1.00 18.41 O

ATOM 8142 C GLU C 297 1.489 -10.949 55.910 1.00 15.95 C

ATOM 8143 O GLU C 297 1.447 -12.120 55.532 1.00 15.72 O

ATOM 8144 N SER C 298 2.373 -10.496 56.799 1.00 15.71 N

ATOM 8145 CA SER C 298 3.419 -11.345 57.373 1.00 15.27 C

ATOM 8146 CB SER C 298 4.331 -10.529 58.294 1.00 15.54 C

ATOM 8147 OG SER C 298 5.259 -11.356 58.982 1.00 16.61 O

ATOM 8148 C SER C 298 2.808 -12.520 58.128 1.00 14.60 C

ATOM 8149 O SER C 298 1.858 -12.347 58.894 1.00 14.67 O

ATOM 8150 N GLY C 299 3.348 -13.712 57.888 1.00 13.75 N

ATOM 8151 CA GLY C 299 2.865 -14.931 58.527 1.00 13.02 C

ATOM 8152 C GLY C 299 1.491 -15.387 58.058 1.00 12.54 C

ATOM 8153 O GLY C 299 0.900 -16.277 58.658 1.00 12.54 O

ATOM 8154 N ILE C 300 0.997 -14.782 56.979 1.00 11.99 N

ATOM 8155 CA ILE C 300 0.338 -15.050 56.454 1.00 11.86 C

ATOM 8156 CB ILE C 300 1.288 -13.841 56.706 1.00 11.95 C

ATOM 8157 CGl ILE C 300 1.564 -13.644 58.205 1.00 12.62 C

ATOM 8158 CDl ILE C 300 2.769 -14.392 58.723 1.00 12.99 C

ATOM 8159 CG2 ILE C 300 2.594 -13.963 55.890 1.00 12.19 C

ATOM 8160 C ILE C 300 0.282 -15.310 54.948 1.00 11.65 C

ATOM 8161 O ILE C 300 0.400 -14.591 54.209 1.00 11.20 O

ATOM 8162 N TRP C 301 0.999 -16.343 54.508 1.00 11.32 N

ATOM 8163 CA TRP C 301 1.255 -16.569 53.092 1.00 11.12 C

ATOM 8164 CB TRP C 301 0.512 -17.813 52.580 1.00 11.42 C

ATOM 8165 CG TRP C 301 0.923 -17.575 52.142 1.00 11.52 C

ATOM 8166 CDl TRP C 301 1.507 -16.376 51.831 1.00 11.82 C

ATOM 8167 NEl TRP C 301 2.818 -16.568 51.455 1.00 11.81 N

ATOM 8168 CE2 TRP C 301 3.103 -17.908 51.507 1.00 11.84 C

ATOM 8169 CD2 TRP C 301 1.930 -18.576 51.926 1.00 11.60 C W2025-7029WO / AM102903-PCT

ATOM 8170 CE3 TRP C 301 1.957 -19.973 52.063 1.00 11.44 C

ATOM 8171 CZ3 TRP C 301 3.139 -20.649 51.777 1.00 11.84 C

ATOM 8172 CH2 TRP C 301 4.292 -19.954 51.362 1.00 11.89 C

ATOM 8173 CZ2 TRP C 301 4.293 -18.589 51.222 1.00 12.01 C

ATOM 8174 C TRP C 301 2.755 -16.719 52.837 1.00 10.88 C

ATOM 8175 O TRP C 301 3.431 -17.521 53.492 1.00 10.92 O

ATOM 8176 N ALA C 302 3.270 -15.941 51.889 1.00 10.43 N

ATOM 8177 CA ALA C 302 4.626 -16.135 51.381 1.00 10.12 C

ATOM 8178 CB ALA C 302 4.913 -15.138 50.281 1.00 10.16 C

ATOM 8179 C ALA C 302 4.747 -17.562 50.848 1.00 10.07 C

ATOM 8180 O ALA C 302 3.743 -18.165 50.459 1.00 9.63 O

ATOM 8181 N TYR C 303 5.959 -18.113 50.835 1.00 10.07 N

ATOM 8182 CA TYR C 303 6.136 -19.464 50.297 1.00 10.09 C

ATOM 8183 CB TYR C 303 7.594 -19.931 50.352 1.00 9.99 C

ATOM 8184 CG TYR C 303 7.779 -21.326 49.784 1.00 9.91 C

ATOM 8185 CDl TYR C 303 7.175 -22.434 50.391 1.00 9.01 C

ATOM 8186 CEl TYR C 303 7.336 -23.713 49.877 1.00 9.80 C

ATOM 8187 CZ TYR C 303 8.104 -23.896 48.735 1.00 9.95 C

ATOM 8188 OH TYR C 303 8.273 -25.162 48.221 1.00 10.58 O

ATOM 8189 CE2 TYR C 303 8.711 -22.816 48.115 1.00 9.21 C

ATOM 8190 CD2 TYR C 303 8.541 -21.537 48.635 1.00 9.30 C

ATOM 8191 C TYR C 303 5.588 -19.600 48.872 1.00 10.02 C

ATOM 8192 O TYR C 303 4.992 -20.621 48.537 1.00 10.42 O

ATOM 8193 N TYR C 304 5.774 -18.570 48.049 1.00 10.30 N

ATOM 8194 CA TYR C 304 5.271 -18.609 46.674 1.00 10.45 C

ATOM 8195 CB TYR C 304 5.974 -17.588 45.759 1.00 10.38 C

ATOM 8196 CG TYR C 304 5.776 -16.125 46.094 1.00 10.66 C

ATOM 8197 CDl TYR C 304 6.728 -15.428 46.840 1.00 10.37 C

ATOM 8198 CEl TYR C 304 6.565 -14.084 47.132 1.00 10.98 C

ATOM 8199 CZ TYR C 304 5.439 -13.414 46.676 1.00 10.62 C

ATOM 8200 OH TYR C 304 5.278 -12.082 46.972 1.00 10.88 O

ATOM 8201 CE2 TYR C 304 4.484 -14.077 45.922 1.00 10.81 C

ATOM 8202 CD2 TYR C 304 4.660 -15.426 45.631 1.00 10.09 C

ATOM 8203 C TYR C 304 3.739 -18.516 46.611 1.00 10.56 C

ATOM 8204 O TYR C 304 3.120 -19.033 45.677 1.00 10.14 O

ATOM 8205 N GLU C 305 3.143 -17.874 47.618 1.00 10.65 N

ATOM 8206 CA GLU C 305 1.683 -17.821 47.754 1.00 10.74 C

ATOM 8207 CB GLU C 305 1.253 -16.732 48.740 1.00 10.78 C

ATOM 8208 CG GLU C 305 1.437 -15.324 48.197 1.00 10.80 C

ATOM 8209 CD GLU C 305 1.108 -14.230 49.199 1.00 10.43 C

ATOM 8210 OEl GLU C 305 1.346 -14.414 50.415 1.00 9.28 O

ATOM 8211 OE2 GLU C 305 0.631 -13.164 48.753 1.00 9.87 O

ATOM 8212 C GLU C 305 1.116 -19.181 48.160 1.00 10.93 C

ATOM 8213 O GLU C 305 0.021 -19.555 47.731 1.00 11.00 O

ATOM 8214 N ILE C 306 1.871 -19.916 48.975 1.00 10.97 N

ATOM 8215 CA ILE C 306 1.531 -21.293 49.333 1.00 11.29 C

ATOM 8216 CB ILE C 306 2.422 -21.827 50.498 1.00 11.19 C

ATOM 8217 CGl ILE C 306 2.182 -21.003 51.768 1.00 11.02 C

ATOM 8218 CDl ILE C 306 3.262 -21.159 52.838 1.00 10.95 C

ATOM 8219 CG2 ILE C 306 2.138 -23.307 50.781 1.00 11.03 C

ATOM 8220 C ILE C 306 1.596 -22.218 48.108 1.00 11.70 C

ATOM 8221 O ILE C 306 0.737 -23.085 47.935 1.00 11.64 O

ATOM 8222 N CYS C 307 2.605 -22.027 47.260 1.00 12.12 N

ATOM 8223 CA CYS C 307 2.726 -22.808 46.025 1.00 12.80 C

ATOM 8224 CB CYS C 307 4.030 -22.481 45.302 1.00 12.75 C

ATOM 8225 SG CYS C 307 5.488 -23.105 46.165 1.00 14.09 S

ATOM 8226 C CYS C 307 1.516 -22.664 45.086 1.00 12.98 C

ATOM 8227 O CYS C 307 1.158 -23.610 44.381 1.00 13.29 O

ATOM 8228 N THR C 308 0.893 -21.485 45.094 1.00 13.30 N

ATOM 8229 CA THR C 308 0.386 -21.245 44.416 1.00 13.50 C

ATOM 8230 CB THR C 308 0.779 -19.737 44.461 1.00 13.41 C

ATOM 8231 OGl THR C 308 0.270 -18.949 43.890 1.00 13.94 O

ATOM 8232 CG2 THR C 308 2.062 -19.474 43.684 1.00 13.75 C W2025-7029WO / AM102903-PCT

ATOM 8233 C THR C 308 1.497 -22.077 45.060 1.00 13.54 C

ATOM 8234 O THR C 308 2.276 -22.734 44.365 1.00 13.72 O

ATOM 8235 N PHE C 309 1.564 -22.034 46.391 1.00 13.58 N

ATOM 8236 CA PHE C 309 2.518 -22.827 47.169 1.00 13.51 C

ATOM 8237 CB PHE C 309 2.248 -22.618 48.665 1.00 13.27 C

ATOM 8238 CG PHE C 309 3.265 -23.253 49.592 1.00 12.34 C

ATOM 8239 CDl PHE C 309 4.625 -22.972 49.475 1.00 12.42 C

ATOM 8240 CEl PHE C 309 5.549 -23.535 50.357 1.00 11.02 C

ATOM 8241 CZ PHE C 309 5.114 -24.375 51.380 1.00 11.77 C

ATOM 8242 CE2 PHE C 309 3.758 -24.647 51.523 1.00 10.78 C

ATOM 8243 CD2 PHE C 309 2.842 -24.077 50.633 1.00 11.45 C

ATOM 8244 C PHE C 309 2.429 -24.308 46.772 1.00 13.81 C

ATOM 8245 O PHE C 309 3.453 -24.949 46.528 1.00 13.65 O

ATOM 8246 N LEU C 310 1.202 -24.823 46.664 1.00 14.21 N

ATOM 8247 CA LEU C 310 0.953 -26.214 46.261 1.00 14.90 C

ATOM 8248 CB LEU C 310 0.495 -26.628 46.570 1.00 14.81 C

ATOM 8249 CG LEU C 310 1.046 -26.384 47.984 1.00 14.72 C

ATOM 8250 CDl LEU C 310 2.541 -26.722 48.081 1.00 14.84 C

ATOM 8251 CD2 LEU C 310 0.254 -27.130 49.042 1.00 14.05 C

ATOM 8252 C LEU C 310 1.282 -26.482 44.787 1.00 15.49 C

ATOM 8253 O LEU C 310 1.775 -27.562 44.450 1.00 15.59 O

ATOM 8254 N LYS C 311 1.003 -25.503 43.924 1.00 16.03 N

ATOM 8255 CA LYS C 311 1.310 -25.594 42.494 1.00 16.87 C

ATOM 8256 CB LYS C 311 0.642 -24.454 41.722 1.00 16.96 C

ATOM 8257 CG LYS C 311 0.741 -24.769 41.174 1.00 17.73 C

ATOM 8258 CD LYS C 311 1.364 -23.526 40.530 1.00 17.85 C

ATOM 8259 CE LYS C 311 2.492 -23.898 39.572 1.00 20.18 C

ATOM 8260 NZ LYS C 311 3.196 -22.691 39.025 1.00 20.97 N

ATOM 8261 C LYS C 311 2.811 -25.573 42.216 1.00 16.87 C

ATOM 8262 O LYS C 311 3.274 -26.128 41.219 1.00 17.19 O

ATOM 8263 N ASN C 312 3.565 -24.917 43.093 1.00 17.02 N

ATOM 8264 CA ASN C 312 5.013 -24.811 42.931 1.00 17.23 C

ATOM 8265 CB ASN C 312 5.505 -23.441 43.409 1.00 17.39 C

ATOM 8266 CG ASN C 312 4.936 -22.289 42.576 1.00 18.99 C

ATOM 8267 ODl ASN C 312 4.302 -22.503 41.534 1.00 20.17 O

ATOM 8268 ND2 ASN C 312 5.161 -21.061 43.036 1.00 20.42 N

ATOM 8269 C ASN C 312 5.790 -25.962 43.581 1.00 16.75 C

ATOM 8270 O ASN C 312 7.017 -25.902 43.712 1.00 17.03 O

ATOM 8271 N GLY C 313 5.065 -27.003 43.986 1.00 16.47 N

ATOM 8272 CA GLY C 313 5.675 -28.246 44.463 1.00 16.01 C

ATOM 8273 C GLY C 313 5.699 -28.514 45.959 1.00 15.85 C

ATOM 8274 O GLY C 313 6.444 -29.390 46.416 1.00 16.17 O

ATOM 8275 N ALA C 314 4.891 -27.785 46.729 1.00 15.32 N

ATOM 8276 CA ALA C 314 4.791 -28.029 48.172 1.00 15.00 C

ATOM 8277 CB ALA C 314 4.022 -26.919 48.855 1.00 15.01 C

ATOM 8278 C ALA C 314 4.139 -29.377 48.470 1.00 14.57 C

ATOM 8279 O ALA C 314 3.211 -29.789 47.774 1.00 14.52 O

ATOM 8280 N THR C 315 4.642 -30.049 49.505 1.00 14.08 N

ATOM 8281 CA THR C 315 4.099 -31.323 49.980 1.00 13.80 C

ATOM 8282 CB THR C 315 5.206 -32.166 50.677 1.00 13.95 C

ATOM 8283 OGl THR C 315 6.339 -32.293 49.806 1.00 13.29 O

ATOM 8284 CG2 THR C 315 4.698 -33.560 51.059 1.00 13.75 C

ATOM 8285 C THR C 315 2.942 -31.062 50.952 1.00 13.70 C

ATOM 8286 O THR C 315 3.084 -30.272 51.883 1.00 13.65 O

ATOM 8287 N GLN C 316 1.805 -31.718 50.726 1.00 13.37 N

ATOM 8288 CA GLN C 316 0.639 -31.591 51.608 1.00 13.24 C

ATOM 8289 CB GLN C 316 0.665 -31.754 50.827 1.00 13.69 C

ATOM 8290 CG GLN C 316 1.038 -30.606 49.932 1.00 15.02 C

ATOM 8291 CD GLN C 316 2.315 -30.892 49.163 1.00 16.75 C

ATOM 8292 OEl GLN C 316 3.394 -31.028 49.750 1.00 16.73 O

ATOM 8293 NE2 GLN C 316 2.198 -30.992 47.841 1.00 16.15 N

ATOM 8294 C GLN C 316 0.641 -32.646 52.701 1.00 12.78 C

ATOM 8295 O GLN C 316 1.129 -33.761 52.504 1.00 12.75 O W2025-7029WO / AM102903-PCT

ATOM 8296 N GLY C 317 0.073 -32.286 53.846 1.00 12.17 N

ATOM 8297 CA GLY C 317 -0.195 -33.232 54.918 1.00 11.58 C

ATOM 8298 C GLY C 317 -1.630 -33.092 55.385 1.00 11.17 C

ATOM 8299 O GLY C 317 -2.245 -32.037 55.218 1.00 11.30 O

ATOM 8300 N TRP C 318 -2.166 -34.166 55.952 1.00 10.69 N

ATOM 8301 CA TRP C 318 -3.472 -34.141 56.591 1.00 10.27 C

ATOM 8302 CB TRP C 318 -4.415 -35.163 55.945 1.00 9.98 C

ATOM 8303 CG TRP C 318 -5.816 -35.140 56.511 1.00 9.91 C

ATOM 8304 CDl TRP C 318 -6.397 -36.088 57.312 1.00 9.80 C

ATOM 8305 NEl TRP C 318 -7.684 -35.720 57.628 1.00 9.90 N

ATOM 8306 CE2 TRP C 318 -7.959 -34.515 57.036 1.00 9.85 C

ATOM 8307 CD2 TRP C 318 -6.803 -34.118 56.321 1.00 9.69 C

ATOM 8308 CE3 TRP C 318 -6.825 -32.904 55.614 1.00 9.17 C

ATOM 8309 CZ3 TRP C 318 -7.985 -32.135 55.646 1.00 9.64 C

ATOM 8310 CH2 TRP C 318 -9.119 -32.559 56.369 1.00 9.61 C

ATOM 8311 CZ2 TRP C 318 -9.124 -33.741 57.068 1.00 9.62 C

ATOM 8312 C TRP C 318 -3.309 -34.395 58.092 1.00 10.21 C

ATOM 8313 O TRP C 318 -2.937 -35.494 58.516 1.00 10.17 O

ATOM 8314 N ASP C 319 -3.561 -33.350 58.877 1.00 9.95 N

ATOM 8315 CA ASP C 319 -3.519 -33.401 60.336 1.00 9.83 C

ATOM 8316 CB ASP C 319 -3.367 -31.971 60.879 1.00 9.64 C

ATOM 8317 CG ASP C 319 -3.355 -31.884 62.405 1.00 8.88 C

ATOM 8318 ODl ASP C 319 -3.336 -30.741 62.897 1.00 7.49 O

ATOM 8319 OD2 ASP C 319 -3.364 -32.911 63.115 1.00 8.83 O

ATOM 8320 C ASP C 319 -4.809 -34.086 60.811 1.00 10.03 C

ATOM 8321 O ASP C 319 -5.786 -33.422 61.169 1.00 9.83 O

ATOM 8322 N ALA C 320 -4.789 -35.422 60.800 1.00 10.02 N

ATOM 8323 CA ALA C 320 -6.003 -36.238 60.964 1.00 10.23 C

ATOM 8324 CB ALA C 320 -5.690 -37.739 60.788 1.00 10.18 C

ATOM 8325 C ALA C 320 -6.811 -35.981 62.247 1.00 10.24 C

ATOM 8326 O ALA C 320 -8.019 -35.773 62.163 1.00 10.30 O

ATOM 8327 N PRO C 321 -6.157 -35.983 63.429 1.00 10.39 N

ATOM 8328 CA PRO C 321 -6.905 -35.700 64.667 1.00 10.62 C

ATOM 8329 CB PRO C 321 -5.812 -35.698 65.737 1.00 10.46 C

ATOM 8330 CG PRO C 321 -4.743 -36.573 65.175 1.00 10.34 C

ATOM 8331 CD PRO C 321 -4.736 -36.257 63.716 1.00 10.25 C

ATOM 8332 C PRO C 321 -7.644 -34.357 64.674 1.00 10.78 C

ATOM 8333 O PRO C 321 -8.719 -34.249 65.274 1.00 11.19 O

ATOM 8334 N GLN C 322 -7.085 -33.352 64.003 1.00 10.61 N

ATOM 8335 CA GLN C 322 -7.647 -31.999 64.033 1.00 10.23 C

ATOM 8336 CB GLN C 322 -6.531 -30.966 64.213 1.00 10.03 C

ATOM 8337 CG GLN C 322 -5.602 -31.277 65.377 1.00 9.42 C

ATOM 8338 CD GLN C 322 -4.869 -30.059 65.890 1.00 9.16 C

ATOM 8339 OEl GLN C 322 -5.368 -29.343 66.763 1.00 9.38 O

ATOM 8340 NE2 GLN C 322 -3.667 -29.826 65.370 1.00 7.17 N

ATOM 8341 C GLN C 322 -8.505 -31.678 62.805 1.00 10.34 C

ATOM 8342 O GLN C 322 -9.135 -30.615 62.738 1.00 10.24 O

ATOM 8343 N GLU C 323 -8.523 -32.609 61.849 1.00 10.16 N

ATOM 8344 CA GLU C 323 -9.343 -32.522 60.629 1.00 10.39 C

ATOM 8345 CB GLU C 323 10.852 -32.597 60.952 1.00 10.65 C

ATOM 8346 CG GLU C 323 11.278 -33.765 61.852 1.00 12.00 C

ATOM 8347 CD GLU C 323 11.317 -35.112 61.139 1.00 14.27 C

ATOM 8348 OEl GLU C 323 11.526 -36.132 61.833 1.00 16.83 O

ATOM 8349 OE2 GLU C 323 11.140 -35.163 59.901 1.00 14.64 O

ATOM 8350 C GLU C 323 -9.032 -31.296 59.764 1.00 9.94 C

ATOM 8351 O GLU C 323 -9.941 -30.659 59.224 1.00 10.01 O

ATOM 8352 N VAL C 324 -7.744 -30.977 59.631 1.00 9.37 N

ATOM 8353 CA VAL C 324 -7.294 -29.817 58.850 1.00 8.92 C

ATOM 8354 CB VAL C 324 -7.083 -28.549 59.739 1.00 8.87 C

ATOM 8355 CGl VAL C 324 -8.412 -27.846 60.015 1.00 8.16 C

ATOM 8356 CG2 VAL C 324 -6.379 -28.903 61.038 1.00 8.66 C

ATOM 8357 C VAL C 324 -6.004 -30.126 58.085 1.00 8.98 C

ATOM 8358 O VAL C 324 -5.181 -30.918 58.553 1.00 8.62 O W2025-7029WO / AM102903-PCT

ATOM 8359 N PRO C 325 -5.827 -29.512 56.899 1.00 8.94 N

ATOM 8360 CA PRO C 325 -4.598 -29.725 56.140 1.00 8.94 C

ATOM 8361 CB PRO C 325 -4.993 -29.282 54.735 1.00 8.77 C

ATOM 8362 CG PRO C 325 -5.958 -28.173 54.980 1.00 8.57 C

ATOM 8363 CD PRO C 325 -6.761 -28.624 56.179 1.00 8.77 C

ATOM 8364 C PRO C 325 -3.436 -28.862 56.616 1.00 9.04 C

ATOM 8365 O PRO C 325 -3.633 -27.858 57.299 1.00 8.94 O

ATOM 8366 N TYR C 326 -2.229 -29.274 56.248 1.00 9.16 N

ATOM 8367 CA TYR C 326 -1.064 -28.408 56.300 1.00 9.33 C

ATOM 8368 CB TYR C 326 -0.290 -28.556 57.623 1.00 9.11 C

ATOM 8369 CG TYR C 326 0.337 -29.909 57.890 1.00 9.10 C

ATOM 8370 CDl TYR C 326 1.684 -30.150 57.593 1.00 8.97 C

ATOM 8371 CEl TYR C 326 2.271 -31.382 57.864 1.00 8.85 C

ATOM 8372 CZ TYR C 326 1.512 -32.389 58.438 1.00 9.09 C

ATOM 8373 OH TYR C 326 2.079 -33.614 58.704 1.00 8.89 O

ATOM 8374 CE2 TYR C 326 0.180 -32.171 58.753 1.00 9.21 C

ATOM 8375 CD2 TYR C 326 -0.398 -30.933 58.484 1.00 8.43 C

ATOM 8376 C TYR C 326 -0.203 -28.697 55.077 1.00 9.64 C

ATOM 8377 O TYR C 326 -0.496 -29.620 54.315 1.00 9.57 O

ATOM 8378 N ALA C 327 0.830 -27.887 54.870 1.00 10.36 N

ATOM 8379 CA ALA C 327 1.744 -28.069 53.741 1.00 10.86 C

ATOM 8380 CB ALA C 327 1.166 -27.465 52.470 1.00 10.84 C

ATOM 8381 C ALA C 327 3.099 -27.458 54.059 1.00 11.33 C

ATOM 8382 O ALA C 327 3.202 -26.552 54.891 1.00 11.20 O

ATOM 8383 N TYR C 328 4.135 -27.967 53.399 1.00 12.04 N

ATOM 8384 CA TYR C 328 5.503 -27.548 53.666 1.00 12.81 C

ATOM 8385 CB TYR C 328 6.092 -28.326 54.852 1.00 13.19 C

ATOM 8386 CG TYR C 328 6.043 -29.841 54.714 1.00 13.99 C

ATOM 8387 CDl TYR C 328 4.938 -30.564 55.163 1.00 14.04 C

ATOM 8388 CEl TYR C 328 4.886 -31.955 55.039 1.00 14.84 C

ATOM 8389 CZ TYR C 328 5.956 -32.632 54.470 1.00 14.71 C

ATOM 8390 OH TYR C 328 5.901 -34.007 54.352 1.00 15.12 O

ATOM 8391 CE2 TYR C 328 7.070 -31.937 54.022 1.00 14.07 C

ATOM 8392 CD2 TYR C 328 7.110 -30.549 54.147 1.00 14.13 C

ATOM 8393 C TYR C 328 6.386 -27.703 52.436 1.00 13.11 C

ATOM 8394 O TYR C 328 6.134 -28.553 51.583 1.00 12.87 O

ATOM 8395 N GLN C 329 7.419 -26.869 52.368 1.00 13.70 N

ATOM 8396 CA GLN C 329 8.426 -26.903 51.308 1.00 14.62 C

ATOM 8397 CB GLN C 329 7.974 -26.065 50.112 1.00 14.86 C

ATOM 8398 CG GLN C 329 9.022 -25.884 49.012 1.00 17.59 C

ATOM 8399 CD GLN C 329 8.643 -26.591 47.731 1.00 20.74 C

ATOM 8400 OEl GLN C 329 8.893 -27.790 47.570 1.00 23.44 O

ATOM 8401 NE2 GLN C 329 8.034 -25.852 46.806 1.00 21.05 N

ATOM 8402 C GLN C 329 9.701 -26.321 51.896 1.00 14.48 C

ATOM 8403 O GLN C 329 9.733 -25.146 52.285 1.00 14.61 O

ATOM 8404 N GLY C 330 10.744 -27.143 51.980 1.00 14.44 N

ATOM 8405 CA GLY C 330 11.987 -26.723 52.634 1.00 14.44 C

ATOM 8406 C GLY C 330 11.715 -26.250 54.050 1.00 14.16 C

ATOM 8407 O GLY C 330 11.189 -27.007 54.866 1.00 14.12 O

ATOM 8408 N ASN C 331 12.042 -24.988 54.334 1.00 14.14 N

ATOM 8409 CA ASN C 331 11.854 -24.434 55.680 1.00 14.07 C

ATOM 8410 CB ASN C 331 13.058 -23.578 56.093 1.00 14.51 C

ATOM 8411 CG ASN C 331 13.165 -22.294 55.295 1.00 15.94 C

ATOM 8412 ODl ASN C 331 12.649 -22.191 54.178 1.00 18.54 O

ATOM 8413 ND2 ASN C 331 13.844 -21.301 55.865 1.00 18.54 N

ATOM 8414 C ASN C 331 10.545 -23.656 55.887 1.00 13.35 C

ATOM 8415 O ASN C 331 10.359 -23.025 56.929 1.00 13.51 O

ATOM 8416 N VAL C 332 9.651 -23.700 54.901 1.00 12.44 N

ATOM 8417 CA VAL C 332 8.361 -23.006 54.996 1.00 11.39 C

ATOM 8418 CB VAL C 332 8.055 -22.172 53.718 1.00 11.48 C

ATOM 8419 CGl VAL C 332 6.714 -21.442 53.845 1.00 11.10 C

ATOM 8420 CG2 VAL C 332 9.176 -21.170 53.446 1.00 11.09 C

ATOM 8421 C VAL C 332 7.235 -24.004 55.284 1.00 10.86 C W2025-7029WO / AM102903-PCT

ATOM 8422 O VAL C 332 7.126 -25.034 54.621 1.00 10.66 O

ATOM 8423 N TRP C 333 6.407 -23.681 56.276 1.00 10.15 N

ATOM 8424 CA TRP C 333 5.322 -24.549 56.736 1.00 9.52 C

ATOM 8425 CB TRP C 333 5.719 -25.169 58.077 1.00 9.63 C

ATOM 8426 CG TRP C 333 4.869 -26.313 58.582 1.00 9.02 C

ATOM 8427 CDl TRP C 333 5.163 -27.647 58.495 1.00 9.17 C

ATOM 8428 NEl TRP C 333 4.179 -28.393 59.098 1.00 9.17 N

ATOM 8429 CE2 TRP C 333 3.222 -27.546 59.598 1.00 9.58 C

ATOM 8430 CD2 TRP C 333 3.627 -26.224 59.297 1.00 9.19 C

ATOM 8431 CE3 TRP C 333 2.816 -25.160 59.710 1.00 9.21 C

ATOM 8432 CZ3 TRP C 333 1.634 -25.444 60.393 1.00 9.60 C

ATOM 8433 CH2 TRP C 333 1.260 -26.771 60.676 1.00 9.51 C

ATOM 8434 CZ2 TRP C 333 2.042 -27.831 60.292 1.00 9.57 C

ATOM 8435 C TRP C 333 4.074 -23.697 56.919 1.00 9.26 C

ATOM 8436 O TRP C 333 4.148 -22.605 57.481 1.00 9.26 O

ATOM 8437 N VAL C 334 2.932 -24.193 56.453 1.00 8.69 N

ATOM 8438 CA VAL C 334 1.680 -23.443 56.544 1.00 8.44 C

ATOM 8439 CB VAL C 334 1.309 -22.759 55.181 1.00 8.35 C

ATOM 8440 CGl VAL C 334 1.138 -23.787 54.069 1.00 7.82 C

ATOM 8441 CG2 VAL C 334 0.058 -21.888 55.317 1.00 8.16 C

ATOM 8442 C VAL C 334 0.549 -24.347 57.034 1.00 8.49 C

ATOM 8443 O VAL C 334 0.419 -25.482 56.586 1.00 8.69 O

ATOM 8444 N GLY C 335 -0.238 -23.835 57.974 1.00 8.33 N

ATOM 8445 CA GLY C 335 -1.428 -24.522 58.475 1.00 8.14 C

ATOM 8446 C GLY C 335 -2.647 -23.750 58.007 1.00 8.12 C

ATOM 8447 O GLY C 335 -2.706 -22.522 58.146 1.00 7.67 O

ATOM 8448 N TYR C 336 -3.617 -24.463 57.442 1.00 8.11 N

ATOM 8449 CA TYR C 336 -4.726 -23.809 56.749 1.00 8.18 C

ATOM 8450 CB TYR C 336 -4.285 -23.371 55.336 1.00 8.18 C

ATOM 8451 CG TYR C 336 -3.942 -24.515 54.398 1.00 8.66 C

ATOM 8452 CDl TYR C 336 -2.765 -25.250 54.562 1.00 8.52 C

ATOM 8453 CEl TYR C 336 -2.445 -26.298 53.707 1.00 9.25 C

ATOM 8454 CZ TYR C 336 -3.302 -26.623 52.665 1.00 8.77 C

ATOM 8455 OH TYR C 336 -2.971 -27.661 51.827 1.00 8.51 O

ATOM 8456 CE2 TYR C 336 -4.475 -25.910 52.471 1.00 8.83 C

ATOM 8457 CD2 TYR C 336 -4.787 -24.854 53.338 1.00 8.47 C

ATOM 8458 C TYR C 336 -5.980 -24.674 56.679 1.00 8.09 C

ATOM 8459 O TYR C 336 -6.077 -25.700 57.355 1.00 7.92 O

ATOM 8460 N ASP C 337 -6.937 -24.218 55.874 1.00 7.94 N

ATOM 8461 CA ASP C 337 -8.186 -24.925 55.622 1.00 7.98 C

ATOM 8462 CB ASP C 337 -9.365 -24.149 56.212 1.00 7.67 C

ATOM 8463 CG ASP C 337 -9.641 -24.509 57.662 1.00 7.87 C

ATOM 8464 ODl ASP C 337 -8.959 -23.976 58.570 1.00 7.34 O

ATOM 8465 OD2 ASP C 337 10.549 -25.329 57.893 1.00 6.59 O

ATOM 8466 C ASP C 337 -8.385 -25.100 54.119 1.00 8.02 C

ATOM 8467 O ASP C 337 -8.017 -24.223 53.332 1.00 7.97 O

ATOM 8468 N ASN C 338 -8.965 -26.236 53.727 1.00 8.59 N

ATOM 8469 CA ASN C 338 -9.277 -26.513 52.315 1.00 8.66 C

ATOM 8470 CB ASN C 338 -8.292 -27.538 51.715 1.00 8.79 C

ATOM 8471 CG ASN C 338 -8.277 -28.876 52.460 1.00 9.22 C

ATOM 8472 ODl ASN C 338 -9.155 -29.177 53.277 1.00 9.89 O

ATOM 8473 ND2 ASN C 338 -7.268 -29.691 52.168 1.00 10.09 N

ATOM 8474 C ASN C 338 10.742 -26.936 52.127 1.00 8.61 C

ATOM 8475 O ASN C 338 11.532 -26.858 53.072 1.00 8.19 O

ATOM 8476 N VAL C 339 11.112 -27.357 50.916 1.00 8.72 N

ATOM 8477 CA VAL C 339 12.497 -27.800 50.651 1.00 9.03 C

ATOM 8478 CB VAL C 339 12.693 -28.247 49.176 1.00 9.13 C

ATOM 8479 CGl VAL C 339 14.052 -28.925 48.973 1.00 9.51 C

ATOM 8480 CG2 VAL C 339 12.548 -27.057 48.233 1.00 9.12 C

ATOM 8481 C VAL C 339 12.918 -28.911 51.630 1.00 9.30 C

ATOM 8482 O VAL C 339 14.034 -28.892 52.167 1.00 9.34 O

ATOM 8483 N LYS C 340 12.001 -29.848 51.871 1.00 9.77 N

ATOM 8484 CA LYS C 340 12.226 -31.006 52.742 1.00 10.22 C W2025-7029WO / AM102903-PCT

ATOM 8485 CB LYS C 340 11.058 -32.001 52.634 1.00 10.34 C

ATOM 8486 CG LYS C 340 11.267 -33.329 53.394 1.00 11.11 C

ATOM 8487 CD LYS C 340 10.047 -34.255 53.254 1.00 11.43 C

ATOM 8488 CE LYS C 340 10.246 -35.555 54.020 1.00 13.51 C

ATOM 8489 NZ LYS C 340 -9.027 -36.421 53.970 1.00 15.19 N

ATOM 8490 C LYS C 340 12.469 -30.625 54.202 1.00 10.15 C

ATOM 8491 O LYS C 340 13.434 -31.102 54.814 1.00 10.02 O

ATOM 8492 N SER C 341 11.601 -29.779 54.759 1.00 10.13 N

ATOM 8493 CA SER C 341 11.768 -29.320 56.144 1.00 9.97 C

ATOM 8494 CB SER C 341 10.513 -28.596 56.650 1.00 10.16 C

ATOM 8495 OG SER C 341 10.258 -27.418 55.908 1.00 10.06 O

ATOM 8496 C SER C 341 13.013 -28.444 56.313 1.00 10.00 C

ATOM 8497 O SER C 341 13.717 -28.553 57.318 1.00 9.92 O

ATOM 8498 N PHE C 342 13.287 -27.592 55.325 1.00 10.04 N

ATOM 8499 CA PHE C 342 14.500 -26.769 55.326 1.00 10.19 C

ATOM 8500 CB PHE C 342 14.517 -25.797 54.128 1.00 9.59 C

ATOM 8501 CG PHE C 342 14.059 -24.388 54.459 1.00 9.06 C

ATOM 8502 CDl PHE C 342 12.928 -24.159 55.239 1.00 8.11 C

ATOM 8503 CEl PHE C 342 12.511 -22.853 55.536 1.00 8.12 C

ATOM 8504 CZ PHE C 342 13.219 -21.764 55.043 1.00 8.34 C

ATOM 8505 CE2 PHE C 342 14.345 -21.975 54.252 1.00 8.31 C

ATOM 8506 CD2 PHE C 342 14.758 -23.286 53.963 1.00 9.01 C

ATOM 8507 C PHE C 342 15.769 -27.636 55.347 1.00 10.56 C

ATOM 8508 O PHE C 342 16.700 -27.375 56.118 1.00 10.43 O

ATOM 8509 N ASP C 343 15.785 -28.671 54.511 1.00 11.08 N

ATOM 8510 CA ASP C 343 16.904 -29.604 54.437 1.00 11.65 C

ATOM 8511 CB ASP C 343 16.690 -30.605 53.300 1.00 12.23 C

ATOM 8512 CG ASP C 343 17.948 -31.385 52.962 1.00 14.46 C

ATOM 8513 ODl ASP C 343 19.011 -30.760 52.765 1.00 16.74 O

ATOM 8514 OD2 ASP C 343 17.872 -32.631 52.885 1.00 17.76 O

ATOM 8515 C ASP C 343 17.128 -30.340 55.763 1.00 11.38 C

ATOM 8516 O ASP C 343 18.260 -30.421 56.251 1.00 11.13 O

ATOM 8517 N ILE C 344 16.042 -30.854 56.339 1.00 11.07 N

ATOM 8518 CA ILE C 344 16.074 -31.550 57.632 1.00 11.05 C

ATOM 8519 CB ILE C 344 14.667 -32.107 58.008 1.00 11.39 C

ATOM 8520 CGl ILE C 344 14.289 -33.262 57.069 1.00 11.33 C

ATOM 8521 CDl ILE C 344 12.818 -33.628 57.092 1.00 11.31 C

ATOM 8522 CG2 ILE C 344 14.617 -32.575 59.465 1.00 11.47 C

ATOM 8523 C ILE C 344 16.649 -30.670 58.751 1.00 10.76 C

ATOM 8524 O ILE C 344 17.506 -31.116 59.527 1.00 10.36 O

ATOM 8525 N LYS C 345 16.200 -29.418 58.812 1.00 10.49 N

ATOM 8526 CA LYS C 345 16.667 -28.483 59.835 1.00 10.43 C

ATOM 8527 CB LYS C 345 15.793 -27.227 59.873 1.00 10.46 C

ATOM 8528 CG LYS C 345 14.407 -27.433 60.429 1.00 11.05 C

ATOM 8529 CD LYS C 345 13.529 -26.262 60.011 1.00 12.00 C

ATOM 8530 CE LYS C 345 12.128 -26.391 60.530 1.00 10.97 C

ATOM 8531 NZ LYS C 345 11.402 -25.099 60.320 1.00 10.76 N

ATOM 8532 C LYS C 345 18.118 -28.088 59.599 1.00 10.26 C

ATOM 8533 O LYS C 345 18.868 -27.864 60.555 1.00 9.89 O

ATOM 8534 N ALA C 346 18.508 -28.012 58.325 1.00 10.14 N

ATOM 8535 CA ALA C 346 19.886 -27.683 57.959 1.00 10.02 C

ATOM 8536 CB ALA C 346 20.020 -27.482 56.461 1.00 9.79 C

ATOM 8537 C ALA C 346 20.856 -28.755 58.455 1.00 10.01 C

ATOM 8538 O ALA C 346 21.902 -28.425 59.006 1.00 10.09 O

ATOM 8539 N GLN C 347 20.502 -30.028 58.272 1.00 10.18 N

ATOM 8540 CA GLN C 347 21.320 -31.127 58.787 1.00 10.43 C

ATOM 8541 CB GLN C 347 20.825 -32.493 58.291 1.00 10.74 C

ATOM 8542 CG GLN C 347 20.726 -32.644 56.757 1.00 12.49 C

ATOM 8543 CD GLN C 347 22.036 -32.377 56.009 1.00 14.47 C

ATOM 8544 OEl GLN C 347 23.129 -32.647 56.509 1.00 15.36 O

ATOM 8545 NE2 GLN C 347 21.917 -31.865 54.786 1.00 15.77 N

ATOM 8546 C GLN C 347 21.359 -31.081 60.314 1.00 9.94 C

ATOM 8547 O GLN C 347 22 422 -31.232 60.914 1.00 9.93 O W2025-7029WO / AM102903-PCT

ATOM 8548 N TRP C 348 20.200 -30.834 60.924 1.00 9.54 N

ATOM 8549 CA TRP C 348 20.081 -30.700 62.373 1.00 9.39 C

ATOM 8550 CB TRP C 348 18.617 -30.449 62.763 1.00 8.97 C

ATOM 8551 CG TRP C 348 18.422 -30.220 64.234 1.00 8.55 C

ATOM 8552 CDl TRP C 348 18.220 -31.173 65.194 1.00 8.15 C

ATOM 8553 NEl TRP C 348 18.095 -30.582 66.428 1.00 7.51 N

ATOM 8554 CE2 TRP C 348 18.212 -29.226 66.286 1.00 7.56 C

ATOM 8555 CD2 TRP C 348 18.420 -28.960 64.914 1.00 7.90 C

ATOM 8556 CE3 TRP C 348 18.568 -27.629 64.497 1.00 8.08 C

ATOM 8557 CZ3 TRP C 348 18.512 -26.620 65.453 1.00 8.14 C

ATOM 8558 CH2 TRP C 348 18.300 -26.918 66.815 1.00 8.00 C

ATOM 8559 CZ2 TRP C 348 18.155 -28.210 67.249 1.00 8.24 C

ATOM 8560 C TRP C 348 20.993 -29.594 62.915 1.00 9.57 C

ATOM 8561 O TRP C 348 21.708 -29.790 63.899 1.00 9.71 O

ATOM 8562 N LEU C 349 20.953 -28.439 62.255 1.00 9.88 N

ATOM 8563 CA LEU C 349 21.792 -27.284 62.572 1.00 10.01 C

ATOM 8564 CB LEU C 349 21.548 -26.203 61.514 1.00 10.08 C

ATOM 8565 CG LEU C 349 22.128 -24.796 61.556 1.00 10.22 C

ATOM 8566 CDl LEU C 349 21.285 -23.935 60.625 1.00 10.08 C

ATOM 8567 CD2 LEU C 349 23.604 -24.768 61.150 1.00 9.34 C

ATOM 8568 C LEU C 349 23.272 -27.666 62.597 1.00 9.91 C

ATOM 8569 O LEU C 349 24.000 -27.299 63.525 1.00 9.74 O

ATOM 8570 N LYS C 350 23.708 -28.393 61.569 1.00 10.38 N

ATOM 8571 CA LYS C 350 25.106 -28.815 61.446 1.00 10.75 C

ATOM 8572 CB LYS C 350 25.377 -29.395 60.056 1.00 10.85 C

ATOM 8573 CG LYS C 350 25.227 -28.387 58.924 1.00 11.39 C

ATOM 8574 CD LYS C 350 25.755 -28.926 57.607 1.00 12.31 C

ATOM 8575 CE LYS C 350 24.768 -29.873 56.957 1.00 13.14 C

ATOM 8576 NZ LYS C 350 25.372 -30.555 55.776 1.00 12.55 N

ATOM 8577 C LYS C 350 25.497 -29.822 62.533 1.00 10.76 C

ATOM 8578 O LYS C 350 26.595 -29.749 63.085 1.00 10.87 O

ATOM 8579 N HIS C 351 24.597 -30.755 62.839 1.00 10.94 N

ATOM 8580 CA HIS C 351 24.847 -31.727 63.902 1.00 11.15 C

ATOM 8581 CB HIS C 351 23.705 -32.739 64.003 1.00 11.11 C

ATOM 8582 CG HIS C 351 23.533 -33.580 62.778 1.00 10.41 C

ATOM 8583 NDl HIS C 351 22.333 -34.172 62.448 1.00 9.36 N

ATOM 8584 CEl HIS C 351 22.470 -34.843 61.318 1.00 8.14 C

ATOM 8585 NE2 HIS C 351 23.714 -34.703 60.899 1.00 9.04 N

ATOM 8586 CD2 HIS C 351 24.401 -33.914 61.792 1.00 9.15 C

ATOM 8587 C HIS C 351 25.061 -31.031 65.245 1.00 11.56 C

ATOM 8588 O HIS C 351 25.960 -31.398 66.009 1.00 11.52 O

ATOM 8589 N ASN C 352 24.249 -30.009 65.505 1.00 11.53 N

ATOM 8590 CA ASN C 352 24.301 -29.275 66.769 1.00 11.48 C

ATOM 8591 CB ASN C 352 22.903 -28.795 67.145 1.00 11.47 C

ATOM 8592 CG ASN C 352 21.992 -29.943 67.522 1.00 11.53 C

ATOM 8593 ODl ASN C 352 22.061 -30.460 68.636 1.00 12.06 O

ATOM 8594 ND2 ASN C 352 21.152 -30.367 66.584 1.00 10.78 N

ATOM 8595 C ASN C 352 25.312 -28.133 66.785 1.00 11.35 C

ATOM 8596 O ASN C 352 25.398 -27.367 67.759 1.00 11.32 O

ATOM 8597 N LYS C 353 26.069 -28.036 65.693 1.00 11.12 N

ATOM 8598 CA LYS C 353 27.211 -27.129 65.566 1.00 11.49 C

ATOM 8599 CB LYS C 353 28.367 -27.596 66.465 1.00 11.26 C

ATOM 8600 CG LYS C 353 29.060 -28.855 65.956 1.00 12.36 C

ATOM 8601 CD LYS C 353 30.106 -29.372 66.938 1.00 13.30 C

ATOM 8602 CE LYS C 353 31.149 -30.222 66.224 1.00 16.80 C

ATOM 8603 NZ LYS C 353 32.232 -30.709 67.148 1.00 18.82 N

ATOM 8604 C LYS C 353 26.889 -25.637 65.765 1.00 10.88 C

ATOM 8605 O LYS C 353 27.691 -24.891 66.321 1.00 10.80 O

ATOM 8606 N PHE C 354 25.719 -25.206 65.291 1.00 10.64 N

ATOM 8607 CA PHE C 354 25.365 -23.785 65.321 1.00 10.36 C

ATOM 8608 CB PHE C 354 23.840 -23.581 65.223 1.00 10.49 C

ATOM 8609 CG PHE C 354 23.082 -24.098 66.419 1.00 10.94 C

ATOM 8610 CDl PHE C 354 22.118 -25.091 66.275 1.00 11.62 C W2025-7029WO / AM102903-PCT

ATOM 8611 CEl PHE C 354 21.416 -25.578 67.387 1.00 11.66 C

ATOM 8612 CZ PHE C 354 21.692 -25.074 68.654 1.00 11.60 C

ATOM 8613 CE2 PHE C 354 22.653 -24.084 68.809 1.00 11.52 C

ATOM 8614 CD2 PHE C 354 23.342 -23.602 67.694 1.00 11.64 C

ATOM 8615 C PHE C 354 26.110 -23.025 64.220 1.00 9.85 C

ATOM 8616 O PHE C 354 26.615 -23.633 63.281 1.00 9.79 O

ATOM 8617 N GLY C 355 26.181 -21.702 64.350 1.00 9.40 N

ATOM 8618 CA GLY C 355 26.950 -20.860 63.430 1.00 9.12 C

ATOM 8619 C GLY C 355 26.407 -20.759 62.016 1.00 8.83 C

ATOM 8620 O GLY C 355 27.136 -20.399 61.087 1.00 8.74 O

ATOM 8621 N GLY C 356 25.122 -21.062 61.853 1.00 8.80 N

ATOM 8622 CA GLY C 356 24.494 -21.037 60.542 1.00 8.32 C

ATOM 8623 C GLY C 356 23.012 -20.747 60.595 1.00 8.23 C

ATOM 8624 O GLY C 356 22.362 -20.950 61.624 1.00 8.03 O

ATOM 8625 N ALA C 357 22.484 -20.263 59.475 1.00 7.92 N

ATOM 8626 CA ALA C 357 21.053 -20.007 59.329 1.00 7.96 C

ATOM 8627 CB ALA C 357 20.460 -20.938 58.280 1.00 7.61 C

ATOM 8628 C ALA C 357 20.775 -18.555 58.953 1.00 7.83 C

ATOM 8629 O ALA C 357 21.589 -17.910 58.290 1.00 7.56 O

ATOM 8630 N MET C 358 19.623 -18.051 59.388 1.00 7.63 N

ATOM 8631 CA MET C 358 19.119 -16.770 58.909 1.00 7.60 C

ATOM 8632 CB MET C 358 19.189 -15.678 59.993 1.00 7.65 C

ATOM 8633 CG MET C 358 18.240 -15.840 61.186 1.00 7.82 C

ATOM 8634 SD MET C 358 16.569 -15.191 60.884 1.00 8.60

ATOM 8635 CE MET C 358 16.079 -14.800 62.562 1.00 7.45 C

ATOM 8636 C MET C 358 17.707 -16.960 58.358 1.00 7.64 C

ATOM 8637 O MET C 358 16.983 -17.869 58.778 1.00 7.41 O

ATOM 8638 N VAL C 359 17.330 -16.102 57.416 1.00 7.77 N

ATOM 8639 CA VAL C 359 16.100 -16.276 56.654 1.00 7.84 C

ATOM 8640 CB VAL C 359 16.397 -16.613 55.161 1.00 8.14 C

ATOM 8641 CGl VAL C 359 15.095 -16.831 54.382 1.00 7.22 C

ATOM 8642 CG2 VAL C 359 17.318 -17.828 55.033 1.00 8.00 C

ATOM 8643 C VAL C 359 15.221 -15.024 56.703 1.00 7.92 C

ATOM 8644 O VAL C 359 15.622 -13.946 56.241 1.00 7.57 O

ATOM 8645 N TRP C 360 14.024 -15.184 57.263 1.00 7.89 N

ATOM 8646 CA TRP C 360 12.962 -14.203 57.119 1.00 7.86 C

ATOM 8647 CB TRP C 360 12.306 -13.901 58.471 1.00 7.77 C

ATOM 8648 CG TRP C 360 11.395 -12.716 58.384 1.00 7.61 C

ATOM 8649 CDl TRP C 360 10.066 -12.721 58.067 1.00 7.48 C

ATOM 8650 NEl TRP C 360 -9.575 -11.437 58.058 1.00 7.95 N

ATOM 8651 CE2 TRP C 360 10.592 -10.570 58.364 1.00 8.01 C

ATOM 8652 CD2 TRP C 360 11.760 -11.344 58.567 1.00 7.67 C

ATOM 8653 CE3 TRP C 360 12.956 -10.693 58.909 1.00 7.01 C

ATOM 8654 CZ3 TRP C 360 12.951 -9.305 59.023 1.00 7.62 C

ATOM 8655 CH2 TRP C 360 11.772 -8.561 58.809 1.00 7.77 C

ATOM 8656 CZ2 TRP C 360 10.587 -9.174 58.479 1.00 8.17 C

ATOM 8657 C TRP C 360 11.914 -14.751 56.140 1.00 8.05 C

ATOM 8658 O TRP C 360 11.179 -15.670 56.497 1.00 7.51 O

ATOM 8659 N ALA C 361 11.830 -14.227 54.911 1.00 8.41 N

ATOM 8660 CA ALA C 361 12.684 -13.177 54.357 1.00 8.69 C

ATOM 8661 CB ALA C 361 12.005 -11.830 54.477 1.00 8.65 C

ATOM 8662 C ALA C 361 12.973 -13.491 52.883 1.00 9.00 C

ATOM 8663 O ALA C 361 12.210 -14.217 52.238 1.00 9.18 O

ATOM 8664 N ILE C 362 14.055 -12.931 52.343 1.00 9.20 N

ATOM 8665 CA ILE C 362 14.493 -13.274 50.981 1.00 9.25 C

ATOM 8666 CB ILE C 362 15.876 -12.624 50.625 1.00 9.29 C

ATOM 8667 CGl ILE C 362 16.449 -13.223 49.333 1.00 9.17 C

ATOM 8668 CDl ILE C 362 17.932 -12.937 49.099 1.00 9.66 C

ATOM 8669 CG2 ILE C 362 15.779 -11.095 50.553 1.00 9.46 C

ATOM 8670 C ILE C 362 13.394 -13.014 49.925 1.00 9.29 C

ATOM 8671 O ILE C 362 13.229 -13.784 48.976 1.00 8.96 O

ATOM 8672 N ASP C 363 12.623 -11.951 50.141 1.00 9.24 N

ATOM 8673 CA ASP C 363 11.545 -11.547 49.241 1.00 9.27 C W2025-7029WO / AM102903-PCT

ATOM 8674 CB ASP C 363 11.190 -10.068 49.467 1.00 9.16 C

ATOM 8675 CG ASP C 363 10.915 -9.740 50.925 1.00 9.71 C

ATOM 8676 ODl ASP C 363 -9.838 -10.115 51.428 1.00 8.85 O

ATOM 8677 OD2 ASP C 363 11.766 -9.080 51.561 1.00 10.70 O

ATOM 8678 C ASP C 363 10.285 -12.431 49.313 1.00 9.02 C

ATOM 8679 O ASP C 363 -9.371 -12.263 48.507 1.00 8.83 O

ATOM 8680 N LEU C 364 10.244 -13.365 50.266 1.00 9.07 N

ATOM 8681 CA LEU C 364 -9.091 -14.259 50.429 1.00 8.81 C

ATOM 8682 CB LEU C 364 -8.638 -14.318 51.899 1.00 8.81 C

ATOM 8683 CG LEU C 364 -8.208 -13.021 52.611 1.00 8.87 C

ATOM 8684 CDl LEU C 364 -8.109 -13.251 54.109 1.00 8.77 C

ATOM 8685 CD2 LEU C 364 -6.882 -12.469 52.083 1.00 7.99 C

ATOM 8686 C LEU C 364 -9.335 -15.672 49.865 1.00 9.10 C

ATOM 8687 O LEU C 364 -8.396 -16.461 49.727 1.00 8.36 O

ATOM 8688 N ASP C 365 10.596 -15.981 49.553 1.00 9.28 N

ATOM 8689 CA ASP C 365 10.947 -17.175 48.777 1.00 10.04 C

ATOM 8690 CB ASP C 365 12.475 -17.359 48.778 1.00 10.01 C

ATOM 8691 CG ASP C 365 12.909 -18.796 48.505 1.00 10.52 C

ATOM 8692 ODl ASP C 365 12.054 -19.660 48.214 1.00 12.48 O

ATOM 8693 OD2 ASP C 365 14.123 -19.066 48.588 1.00 10.84 O

ATOM 8694 C ASP C 365 10.419 -17.011 47.337 1.00 10.22 C

ATOM 8695 O ASP C 365 10.070 -15.900 46.928 1.00 10.03 O

ATOM 8696 N ASP C 366 10.355 -18.103 46.575 1.00 10.88 N

ATOM 8697 CA ASP C 366 -9.941 -18.024 45.162 1.00 11.52 C

ATOM 8698 CB ASP C 366 -9.361 -19.363 44.670 1.00 11.60 C

ATOM 8699 CG ASP C 366 -8.817 -19.298 43.229 1.00 11.72 C

ATOM 8700 ODl ASP C 366 -8.645 -18.193 42.668 1.00 10.74 O

ATOM 8701 OD2 ASP C 366 -8.565 -20.377 42.651 1.00 12.81 O

ATOM 8702 C ASP C 366 11.122 -17.570 44.302 1.00 11.95 C

ATOM 8703 O ASP C 366 11.785 -18.381 43.645 1.00 11.98 O

ATOM 8704 N PHE C 367 11.372 -16.263 44.317 1.00 12.63 N

ATOM 8705 CA PHE C 367 12.534 -15.679 43.648 1.00 13.42 C

ATOM 8706 CB PHE C 367 12.862 -14.282 44.205 1.00 13.30 C

ATOM 8707 CG PHE C 367 11.772 -13.261 44.026 1.00 13.71 C

ATOM 8708 CDl PHE C 367 10.745 -13.146 44.959 1.00 13.91 C

ATOM 8709 CEl PHE C 367 -9.742 -12.191 44.805 1.00 13.47 C

ATOM 8710 CZ PHE C 367 -9.770 -11.330 43.716 1.00 13.33 C

ATOM 8711 CE2 PHE C 367 10.797 -11.426 42.781 1.00 13.74 C

ATOM 8712 CD2 PHE C 367 11.794 -12.383 42.942 1.00 14.11 C

ATOM 8713 C PHE C 367 12.441 -15.673 42.119 1.00 13.79 C

ATOM 8714 O PHE C 367 13.462 -15.758 41.436 1.00 13.91 O

ATOM 8715 N THR C 368 11.225 -15.581 41.588 1.00 14.40 N

ATOM 8716 CA THR C 368 11.024 -15.666 40.138 1.00 14.82 C

ATOM 8717 CB THR C 368 -9.681 -15.029 39.681 1.00 14.89 C

ATOM 8718 OGl THR C 368 -8.577 -15.806 40.162 1.00 15.37 O

ATOM 8719 CG2 THR C 368 -9.548 -13.593 40.176 1.00 15.35 C

ATOM 8720 C THR C 368 11.106 -17.114 39.639 1.00 14.95 C

ATOM 8721 O THR C 368 11.387 -17.357 38.463 1.00 15.31 O

ATOM 8722 N GLY C 369 10.862 -18.067 40.538 1.00 15.07 N

ATOM 8723 CA GLY C 369 10.791 -19.482 40.186 1.00 15.34 C

ATOM 8724 C GLY C 369 -9.531 -19.860 39.415 1.00 15.59 C

ATOM 8725 O GLY C 369 -9.417 -20.985 38.918 1.00 15.50 O

ATOM 8726 N THR C 370 -8.583 -18.929 39.333 1.00 15.83 N

ATOM 8727 CA THR C 370 -7.380 -19.098 38.508 1.00 16.17 C

ATOM 8728 CB THR C 370 -6.962 -17.765 37.830 1.00 16.17 C

ATOM 8729 OGl THR C 370 -6.607 -16.793 38.825 1.00 16.47 O

ATOM 8730 CG2 THR C 370 -8.091 -17.219 36.965 1.00 16.56 C

ATOM 8731 C THR C 370 -6.180 -19.673 39.271 1.00 16.47 C

ATOM 8732 O THR C 370 -5.130 -19.956 38.673 1.00 16.56 O

ATOM 8733 N PHE C 371 -6.333 -19.852 40.583 1.00 16.28 N

ATOM 8734 CA PHE C 371 -5.212 -20.278 41.421 1.00 16.52 C

ATOM 8735 CB PHE C 371 -5.089 -19.380 42.659 1.00 16.25 C

ATOM 8736 CG PHE C 371 -4.560 -18.005 42.365 1.00 16.03 C W2025-7029WO / AM102903-PCT

ATOM 8737 CDl PHE C 371 -5.424 -16.972 42.000 1.00 14.83 C

ATOM 8738 CEl PHE C 371 -4.941 -15.703 41.730 1.00 14.87 C

ATOM 8739 CZ PHE C 371 -3.581 -15.444 41.823 1.00 15.56 C

ATOM 8740 CE2 PHE C 371 -2.705 -16.463 42.187 1.00 15.93 C

ATOM 8741 CD2 PHE C 371 -3.200 -17.736 42.459 1.00 15.78 C

ATOM 8742 C PHE C 371 -5.302 -21.741 41.844 1.00 16.81 C

ATOM 8743 O PHE C 371 -4.289 -22.448 41.868 1.00 17.09 O

ATOM 8744 N CYS C 372 -6.515 -22.184 42.169 1.00 16.93 N

ATOM 8745 CA CYS C 372 -6.731 -23.479 42.812 1.00 17.12 C

ATOM 8746 CB CYS C 372 -7.625 -23.311 44.049 1.00 16.93 C

ATOM 8747 SG CYS C 372 -7.023 -22.129 45.282 1.00 15.56 S

ATOM 8748 C CYS C 372 -7.351 -24.508 41.875 1.00 17.57 C

ATOM 8749 O CYS C 372 -7.328 -25.706 42.165 1.00 17.80 O

ATOM 8750 N ASN C 373 -7.904 -24.030 40.760 1.00 18.08 N

ATOM 8751 CA ASN C 373 -8.593 -24.873 39.777 1.00 18.50 C

ATOM 8752 CB ASN C 373 -7.592 -25.768 39.025 1.00 19.00 C

ATOM 8753 CG ASN C 373 -6.426 -24.982 38.435 1.00 20.73 C

ATOM 8754 ODl ASN C 373 -5.266 -25.394 38.545 1.00 23.57 O

ATOM 8755 ND2 ASN C 373 -6.725 -23.846 37.813 1.00 22.19 N

ATOM 8756 C ASN C 373 -9.730 -25.696 40.396 1.00 18.22 C

ATOM 8757 O ASN C 373 -9.890 -26.881 40.098 1.00 18.38 O

ATOM 8758 N GLN C 374 10.510 -25.049 41.262 1.00 17.84 N

ATOM 8759 CA GLN C 374 11.616 -25.696 41.979 1.00 17.55 C

ATOM 8760 CB GLN C 374 11.296 -25.808 43.479 1.00 17.53 C

ATOM 8761 CG GLN C 374 10.116 -26.715 43.835 1.00 17.34 C

ATOM 8762 CD GLN C 374 -9.785 -26.699 45.323 1.00 17.61 C

ATOM 8763 OEl GLN C 374 -9.524 -25.641 45.906 1.00 17.66 O

ATOM 8764 NE2 GLN C 374 -9.783 -27.880 45.943 1.00 16.44 N

ATOM 8765 C GLN C 374 12.915 -24.907 41.781 1.00 17.29 C

ATOM 8766 O GLN C 374 13.878 -25.067 42.539 1.00 17.40 O

ATOM 8767 N GLY C 375 12.931 -24.061 40.754 1.00 16.93 N

ATOM 8768 CA GLY C 375 14.045 -23.148 40.508 1.00 16.72 C

ATOM 8769 C GLY C 375 13.852 -21.825 41.225 1.00 16.40 C

ATOM 8770 O GLY C 375 12.910 -21.664 41.997 1.00 16.61 O

ATOM 8771 N LYS C 376 14.744 -20.873 40.968 1.00 16.28 N

ATOM 8772 CA LYS C 376 14.700 -19.576 41.640 1.00 16.06 C

ATOM 8773 CB LYS C 376 15.481 -18.530 40.845 1.00 16.31 C

ATOM 8774 CG LYS C 376 14.875 -18.217 39.470 1.00 17.61 C

ATOM 8775 CD LYS C 376 15.575 -17.034 38.820 1.00 19.98 C

ATOM 8776 CE LYS C 376 14.844 -16.562 37.573 1.00 21.56 C

ATOM 8777 NZ LYS C 376 15.348 -15.223 37.141 1.00 22.96 N

ATOM 8778 C LYS C 376 15.252 -19.701 43.060 1.00 15.55 C

ATOM 8779 O LYS C 376 16.250 -20.391 43.282 1.00 15.52 O

ATOM 8780 N PHE C 377 14.590 -19.041 44.011 1.00 14.85 N

ATOM 8781 CA PHE C 377 14.961 -19.102 45.430 1.00 14.33 C

ATOM 8782 CB PHE C 377 16.280 -18.355 45.686 1.00 14.14 C

ATOM 8783 CG PHE C 377 16.196 -16.862 45.510 1.00 13.84 C

ATOM 8784 CDl PHE C 377 15.503 -16.076 46.426 1.00 13.71 C

ATOM 8785 CEl PHE C 377 15.448 -14.694 46.279 1.00 13.47 C

ATOM 8786 CZ PHE C 377 16.102 -14.078 45.207 1.00 13.99 C

ATOM 8787 CE2 PHE C 377 16.805 -14.852 44.290 1.00 13.25 C

ATOM 8788 CD2 PHE C 377 16.856 -16.237 44.451 1.00 13.65 C

ATOM 8789 C PHE C 377 15.097 -20.545 45.949 1.00 13.96 C

ATOM 8790 O PHE C 377 16.151 -20.913 46.476 1.00 14.21 O

ATOM 8791 N PRO C 378 14.039 -21.367 45.811 1.00 13.48 N

ATOM 8792 CA PRO C 378 14.235 -22.792 46.117 1.00 13.20 C

ATOM 8793 CB PRO C 378 12.893 -23.428 45.738 1.00 13.09 C

ATOM 8794 CG PRO C 378 11.902 -22.306 45.772 1.00 13.48 C

ATOM 8795 CD PRO C 378 12.658 -21.075 45.381 1.00 13.55 C

ATOM 8796 C PRO C 378 14.589 -23.077 47.582 1.00 12.92 C

ATOM 8797 O PRO C 378 15.452 -23.918 47.855 1.00 12.48 O

ATOM 8798 N LEU C 379 13.943 -22.374 48.507 1.00 12.60 N

ATOM 8799 CA LEU C 379 14.176 -22.599 49.927 1.00 12.40 C W2025-7029WO / AM102903-PCT

ATOM 8800 CB LEU C 379 13.094 -21.924 50.777 1.00 12.36 C

ATOM 8801 CG LEU C 379 11.637 -22.381 50.595 1.00 11.97 C

ATOM 8802 CDl LEU C 379 10.733 -21.684 51.609 1.00 10.50 C

ATOM 8803 CD2 LEU C 379 11.498 -23.898 50.705 1.00 11.11 C

ATOM 8804 C LEU C 379 15.576 -22.163 50.354 1.00 12.38 C

ATOM 8805 O LEU C 379 16.264 -22.897 51.061 1.00 12.45 O

ATOM 8806 N ILE C 380 16.006 -20.987 49.906 1.00 12.48 N

ATOM 8807 CA ILE C 380 17.332 -20.485 50.269 1.00 12.28 C

ATOM 8808 CB ILE C 380 17.476 -18.945 50.073 1.00 12.33 C

ATOM 8809 CGl ILE C 380 16.363 -18.210 50.838 1.00 12.28 C

ATOM 8810 CDl ILE C 380 16.213 -16.731 50.517 1.00 11.62 C

ATOM 8811 CG2 ILE C 380 18.841 -18.474 50.580 1.00 11.49 C

ATOM 8812 C ILE C 380 18.444 -21.270 49.567 1.00 12.71 C

ATOM 8813 O ILE C 380 19.494 -21.530 50.169 1.00 12.68 O

ATOM 8814 N SER C 381 18.206 -21.671 48.316 1.00 12.95 N

ATOM 8815 CA SER C 381 19.162 -22.525 47.592 1.00 13.24 C

ATOM 8816 CB SER C 381 18.721 -22.757 46.141 1.00 13.42 C

ATOM 8817 OG SER C 381 18.564 -21.526 45.459 1.00 14.20 O

ATOM 8818 C SER C 381 19.369 -23.859 48.301 1.00 13.16 C

ATOM 8819 O SER C 381 20.485 -24.388 48.316 1.00 13.01 O

ATOM 8820 N THR C 382 18.294 -24.395 48.887 1.00 13.16 N

ATOM 8821 CA THR C 382 18.370 -25.589 49.740 1.00 13.33 C

ATOM 8822 CB THR C 382 16.993 -25.956 50.350 1.00 13.42 C

ATOM 8823 OGl THR C 382 16.035 -26.149 49.304 1.00 13.66 O

ATOM 8824 CG2 THR C 382 17.082 -27.233 51.186 1.00 13.91 C

ATOM 8825 C THR C 382 19.372 -25.388 50.875 1.00 13.27 C

ATOM 8826 O THR C 382 20.203 -26.259 51.134 1.00 13.29 O

ATOM 8827 N LEU C 383 19.284 -24.237 51.541 1.00 13.44 N

ATOM 8828 CA LEU C 383 20.160 -23.908 52.669 1.00 13.67 C

ATOM 8829 CB LEU C 383 19.671 -22.647 53.399 1.00 13.35 C

ATOM 8830 CG LEU C 383 18.289 -22.740 54.059 1.00 13.21 C

ATOM 8831 CDl LEU C 383 17.960 -21.466 54.831 1.00 12.98 C

ATOM 8832 CD2 LEU C 383 18.174 -23.952 54.975 1.00 12.79 C

ATOM 8833 C LEU C 383 21.621 -23.758 52.258 1.00 13.98 C

ATOM 8834 O LEU C 383 22.497 -24.334 52.894 1.00 14.01 O

ATOM 8835 N LYS C 384 21.871 -22.994 51.195 1.00 14.34 N

ATOM 8836 CA LYS C 384 23.223 -22.809 50.658 1.00 15.08 C

ATOM 8837 CB LYS C 384 23.187 -21.928 49.403 1.00 14.88 C

ATOM 8838 CG LYS C 384 24.552 -21.647 48.778 1.00 15.78 C

ATOM 8839 CD LYS C 384 24.418 -20.845 47.489 1.00 16.09 C

ATOM 8840 CE LYS C 384 25.727 -20.810 46.702 1.00 18.52 C

ATOM 8841 NZ LYS C 384 26.741 -19.887 47.296 1.00 19.78 N

ATOM 8842 C LYS C 384 23.883 -24.154 50.350 1.00 15.16 C

ATOM 8843 O LYS C 384 25.025 -24.398 50.750 1.00 15.11 O

ATOM 8844 N LYS C 385 23.155 -25.015 49.640 1.00 15.35 N

ATOM 8845 CA LYS C 385 23.633 -26.354 49.291 1.00 15.73 C

ATOM 8846 CB LYS C 385 22.632 -27.049 48.362 1.00 15.38 C

ATOM 8847 CG LYS C 385 23.117 -28.380 47.799 1.00 16.72 C

ATOM 8848 CD LYS C 385 22.188 -28.893 46.705 1.00 16.66 C

ATOM 8849 CE LYS C 385 22.683 -30.220 46.134 1.00 19.08 C

ATOM 8850 NZ LYS C 385 21.899 -30.629 44.921 1.00 19.56 N

ATOM 8851 C LYS C 385 23.895 -27.208 50.540 1.00 15.64 C

ATOM 8852 O LYS C 385 24.972 -27.794 50.682 1.00 15.35 O

ATOM 8853 N ALA C 386 22.909 -27.265 51.437 1.00 15.77 N

ATOM 8854 CA ALA C 386 23.007 -28.056 52.668 1.00 16.16 C

ATOM 8855 CB ALA C 386 21.680 -28.051 53.412 1.00 16.07 C

ATOM 8856 C ALA C 386 24.142 -27.604 53.593 1.00 16.60 C

ATOM 8857 O ALA C 386 24.792 -28.430 54.226 1.00 16.55 O

ATOM 8858 N LEU C 387 24.384 -26.296 53.652 1.00 17.12 N

ATOM 8859 CA LEU C 387 25.448 -25.747 54.493 1.00 17.86 C

ATOM 8860 CB LEU C 387 25.104 -24.318 54.946 1.00 17.50 C

ATOM 8861 CG LEU C 387 23.864 -24.175 55.842 1.00 17.14 C

ATOM 8862 CDl LEU C 387 23.458 -22.707 56.012 1.00 16.51 C W2025-7029WO / AM102903-PCT

ATOM 8863 CD2 LEU C 387 24.064 -24.855 57.202 1.00 16.12 C

ATOM 8864 C LEU C 387 26.819 -25.794 53.812 1.00 18.60 C

ATOM 8865 O LEU C 387 27.827 -25.401 54.403 1.00 18.86 O

ATOM 8866 N GLY C 388 26.842 -26.287 52.574 1.00 19.41 N

ATOM 8867 CA GLY C 388 28.078 -26.465 51.806 1.00 20.52 C

ATOM 8868 C GLY C 388 28.812 -25.174 51.492 1.00 21.19 C

ATOM 8869 O GLY C 388 30.044 -25.149 51.464 1.00 21.40 O

ATOM 8870 N LEU C 389 28.057 -24.102 51.255 1.00 21.78 N

ATOM 8871 CA LEU C 389 28.643 -22.786 51.016 1.00 22.50 C

ATOM 8872 CB LEU C 389 27.592 -21.685 51.148 1.00 22.48 C

ATOM 8873 CG LEU C 389 26.797 -21.577 52.453 1.00 23.03 C

ATOM 8874 CDl LEU C 389 25.786 -20.455 52.315 1.00 23.45 C

ATOM 8875 CD2 LEU C 389 27.692 -21.349 53.663 1.00 22.64 C

ATOM 8876 C LEU C 389 29.331 -22.696 49.657 1.00 23.04 C

ATOM 8877 O LEU C 389 28.801 -23.159 48.644 1.00 23.18 O

ATOM 8878 N GLN C 390 30.516 -22.092 49.657 1.00 23.83 N

ATOM 8879 CA GLN C 390 31.326 -21.943 48.453 1.00 24.50 C

ATOM 8880 CB GLN C 390 32.811 -21.860 48.824 1.00 24.90 C

ATOM 8881 CG GLN C 390 33.365 -23.143 49.454 1.00 26.62 C

ATOM 8882 CD GLN C 390 34.639 -22.918 50.256 1.00 28.67 C

ATOM 8883 OEl GLN C 390 35.257 -21.851 50.188 1.00 29.65 O

ATOM 8884 NE2 GLN C 390 35.038 -23.929 51.024 1.00 29.24 N

ATOM 8885 C GLN C 390 30.907 -20.712 47.652 1.00 24.29 C

ATOM 8886 O GLN C 390 30.414 -19.727 48.215 1.00 24.62 O

ATOM 8887 N SER C 391 31.103 -20.779 46.337 1.00 23.80 N

ATOM 8888 CA SER C 391 30.750 -19.685 45.434 1.00 23.10 C

ATOM 8889 CB SER C 391 29.874 -20.210 44.294 1.00 23.28 C

ATOM 8890 OG SER C 391 28.639 -20.691 44.790 1.00 24.01 O

ATOM 8891 C SER C 391 31.988 -18.981 44.875 1.00 22.56 C

ATOM 8892 O SER C 391 31.885 -18.175 43.946 1.00 22.48 O

ATOM 8893 N ALA C 392 33.147 -19.282 45.461 1.00 21.92 N

ATOM 8894 CA ALA C 392 34.436 -18.748 45.012 1.00 21.33 C

ATOM 8895 CB ALA C 392 35.567 -19.294 45.883 1.00 21.52 C

ATOM 8896 C ALA C 392 34.474 -17.221 44.979 1.00 20.77 C

ATOM 8897 O ALA C 392 34.972 -16.624 44.020 1.00 20.64 O

ATOM 8898 N SER C 393 33.924 -16.601 46.022 1.00 19.94 N

ATOM 8899 CA SER C 393 33.914 -15.147 46.172 1.00 19.07 C

ATOM 8900 CB SER C 393 33.400 -14.780 47.564 1.00 19.20 C

ATOM 8901 OG SER C 393 32.094 -15.287 47.770 1.00 18.09 O

ATOM 8902 C SER C 393 33.096 -14.407 45.103 1.00 18.63 C

ATOM 8903 O SER C 393 33.254 -13.197 44.925 1.00 18.58 O

ATOM 8904 N CYS C 394 32.235 -15.137 44.397 1.00 17.99 N

ATOM 8905 CA CYS C 394 31.333 -14.546 43.402 1.00 17.55 C

ATOM 8906 CB CYS C 394 29.992 -15.284 43.402 1.00 17.65 C

ATOM 8907 SG CYS C 394 29.398 -15.795 45.052 1.00 18.83

ATOM 8908 C CYS C 394 31.945 -14.538 41.995 1.00 17.06 C

ATOM 8909 O CYS C 394 31.251 -14.299 40.998 1.00 16.78 O

ATOM 8910 N THR C 395 33.249 -14.793 41.928 1.00 16.49 N

ATOM 8911 CA THR C 395 33.998 -14.789 40.668 1.00 16.25 C

ATOM 8912 CB THR C 395 35.496 -15.169 40.897 1.00 16.40 C

ATOM 8913 OGl THR C 395 36.206 -15.169 39.650 1.00 17.50 O

ATOM 8914 CG2 THR C 395 36.172 -14.204 41.864 1.00 16.91 C

ATOM 8915 C THR C 395 33.845 -13.464 39.900 1.00 15.69 C

ATOM 8916 O THR C 395 33.884 -12.376 40.484 1.00 15.44 O

ATOM 8917 N ALA C 396 33.625 -13.574 38.594 1.00 15.08 N

ATOM 8918 CA ALA C 396 33.484 -12.408 37.727 1.00 14.50 C

ATOM 8919 CB ALA C 396 32.074 -12.348 37.130 1.00 14.55 C

ATOM 8920 C ALA C 396 34.550 -12.448 36.627 1.00 14.11 C

ATOM 8921 O ALA C 396 34.421 -13.206 35.664 1.00 13.97 O

ATOM 8922 N PRO C 397 35.615 -11.638 36.773 1.00 13.64 N

ATOM 8923 CA PRO C 397 36.722 -11.662 35.818 1.00 13.38 C

ATOM 8924 CB PRO C 397 37.830 -10.913 36.562 1.00 13.29 C

ATOM 8925 CG PRO C 397 37.095 -9.941 37.413 1.00 13.40 C W2025-7029WO / AM102903-PCT

ATOM 8926 CD PRO C 397 35.838 -10.647 37.845 1.00 13.63 C

ATOM 8927 C PRO C 397 36.394 -10.940 34.507 1.00 13.10 C

ATOM 8928 O PRO C 397 35.379 -10.247 34.421 1.00 12.97 O

ATOM 8929 N ALA C 398 37.261 -11.104 33.509 1.00 12.87 N

ATOM 8930 CA ALA C 398 37.146 -10.394 32.233 1.00 12.95 C

ATOM 8931 CB ALA C 398 37.900 -11.138 31.137 1.00 12.65 C

ATOM 8932 C ALA C 398 37.632 -8.938 32.365 1.00 13.10 C

ATOM 8933 O ALA C 398 38.598 -8.518 31.727 1.00 12.85 O

ATOM 8934 N GLN C 399 36.953 -8.194 33.234 1.00 13.68 N

ATOM 8935 CA GLN C 399 37.172 -6.767 33.443 1.00 14.49 C

ATOM 8936 CB GLN C 399 38.029 -6.503 34.687 1.00 14.33 C

ATOM 8937 CG GLN C 399 39.396 -7.193 34.709 1.00 14.19 C

ATOM 8938 CD GLN C 399 40.165 -6.940 35.996 1.00 14.30 C

ATOM 8939 OEl GLN C 399 40.156 -5.832 36.534 1.00 13.70 O

ATOM 8940 NE2 GLN C 399 40.838 -7.971 36.495 1.00 13.69 N

ATOM 8941 C GLN C 399 35.785 -6.159 33.640 1.00 15.16 C

ATOM 8942 O GLN C 399 35.032 -6.614 34.502 1.00 15.45 O

ATOM 8943 N PRO C 400 35.423 -5.156 32.824 1.00 15.88 N

ATOM 8944 CA PRO C 400 34.090 -4.573 32.948 1.00 16.56 C

ATOM 8945 CB PRO C 400 33.926 -3.794 31.642 1.00 16.69 C

ATOM 8946 CG PRO C 400 35.304 -3.433 31.247 1.00 16.66 C

ATOM 8947 CD PRO C 400 36.204 -4.530 31.745 1.00 16.07 C

ATOM 8948 C PRO C 400 33.986 -3.648 34.156 1.00 16.90 C

ATOM 8949 O PRO C 400 33.425 -4.045 35.179 1.00 17.48 O

ATOM 8950 N TYR D 22 56.630 27.849 26.363 1.00 8.88 N

ATOM 8951 CA TYR D 22 55.301 28.181 25.768 1.00 9.31 C

ATOM 8952 CB TYR D 22 54.246 27.117 26.131 1.00 9.15 C

ATOM 8953 CG TYR D 22 54.601 25.710 25.687 1.00 9.52 C

ATOM 8954 CDl TYR D 22 55.210 24.811 26.569 1.00 9.08 C

ATOM 8955 CEl TYR D 22 55.548 23.523 26.170 1.00 8.83 C

ATOM 8956 CZ TYR D 22 55.274 23.118 24.872 1.00 9.56 C

ATOM 8957 OH TYR D 22 55.606 21.844 24.469 1.00 9.75 O

ATOM 8958 CE2 TYR D 22 54.669 23.990 23.972 1.00 10.30 C

ATOM 8959 CD2 TYR D 22 54.333 25.280 24.385 1.00 9.55 C

ATOM 8960 C TYR D 22 54.805 29.562 26.190 1.00 9.28 C

ATOM 8961 O TYR D 22 55.186 30.086 27.243 1.00 9.44 O

ATOM 8962 N GLN D 23 53.945 30.137 25.354 1.00 9.33 N

ATOM 8963 CA GLN D 23 53.257 31.381 25.663 1.00 9.27 C

ATOM 8964 CB GLN D 23 53.063 32.215 24.388 1.00 9.51 C

ATOM 8965 CG GLN D 23 54.357 32.734 23.754 1.00 11.47 C

ATOM 8966 CD GLN D 23 55.213 33.532 24.722 1.00 13.72 C

ATOM 8967 OEl GLN D 23 54.713 34.390 25.447 1.00 15.96 O

ATOM 8968 NE2 GLN D 23 56.512 33.247 24.739 1.00 14.87 N

ATOM 8969 C GLN D 23 51.894 31.126 26.302 1.00 8.55 C

ATOM 8970 O GLN D 23 51.199 30.168 25.963 1.00 8.61 O

ATOM 8971 N LEU D 24 51.521 31.996 27.227 1.00 8.00 N

ATOM 8972 CA LEU D 24 50.147 32.076 27.699 1.00 7.54 C

ATOM 8973 CB LEU D 24 50.015 31.571 29.140 1.00 7.59 C

ATOM 8974 CG LEU D 24 48.609 31.581 29.755 1.00 7.12 C

ATOM 8975 CDl LEU D 24 47.597 30.832 28.892 1.00 6.65 C

ATOM 8976 CD2 LEU D 24 48.620 31.023 31.185 1.00 7.37 C

ATOM 8977 C LEU D 24 49.691 33.527 27.566 1.00 7.57 C

ATOM 8978 O LEU D 24 50.093 34.393 28.341 1.00 7.23 O

ATOM 8979 N THR D 25 48.862 33.773 26.560 1.00 7.50 N

ATOM 8980 CA THR D 25 48.452 35.125 26.193 1.00 7.50 C

ATOM 8981 CB THR D 25 48.637 35.345 24.680 1.00 7.31 C

ATOM 8982 OGl THR D 25 50.024 35.206 24.353 1.00 7.24 O

ATOM 8983 CG2 THR D 25 48.183 36.717 24.260 1.00 7.47 C

ATOM 8984 C THR D 25 47.008 35.363 26.633 1.00 7.45 C

ATOM 8985 O THR D 25 46.098 34.645 26.223 1.00 7.52 O

ATOM 8986 N CYS D 26 46.806 36.354 27.492 1.00 7.38 N

ATOM 8987 CA CYS D 26 45.487 36.571 28.095 1.00 7.52 C

ATOM 8988 CB CYS D 26 45.566 36.399 29.616 1.00 7.56 C W2025-7029WO / AM102903-PCT

ATOM 8989 SG CYS D 26 46.358 34.842 30.137 1.00 9.09

ATOM 8990 C CYS D 26 44.905 37.939 27.730 1.00 7.15 C

ATOM 8991 O CYS D 26 45.542 38.969 27.959 1.00 7.12 O

ATOM 8992 N TYR D 27 43.696 37.932 27.163 1.00 6.89 N

ATOM 8993 CA TYR D 27 42.996 39.164 26.767 1.00 6.61 C

ATOM 8994 CB TYR D 27 42.036 38.894 25.602 1.00 6.77 C

ATOM 8995 CG TYR D 27 42.694 38.735 24.243 1.00 6.85 C

ATOM 8996 CDl TYR D 27 42.809 39.823 23.372 1.00 7.45 C

ATOM 8997 CEl TYR D 27 43.416 39.685 22.112 1.00 6.70 C

ATOM 8998 CZ TYR D 27 43.906 38.442 21.720 1.00 6.96 C

ATOM 8999 OH TYR D 27 44.500 38.293 20.481 1.00 5.85 O

ATOM 9000 CE2 TYR D 27 43.797 37.345 22.567 1.00 6.45 C

ATOM 9001 CD2 TYR D 27 43.190 37.495 23.819 1.00 7.56 C

ATOM 9002 C TYR D 27 42.224 39.783 27.934 1.00 6.49 C

ATOM 9003 O TYR D 27 41.443 39.099 28.603 1.00 6.47 O

ATOM 9004 N PHE D 28 42.475 41.072 28.172 1.00 6.22 N

ATOM 9005 CA PHE D 28 41.733 41.900 29.119 1.00 6.14 C

ATOM 9006 CB PHE D 28 42.705 42.742 29.966 1.00 6.37 C

ATOM 9007 CG PHE D 28 42.070 43.942 30.641 1.00 5.91 C

ATOM 9008 CDl PHE D 28 41.408 43.804 31.860 1.00 6.42 C

ATOM 9009 CEl PHE D 28 40.824 44.909 32.492 1.00 6.34 C

ATOM 9010 CZ PHE D 28 40.900 46.173 31.896 1.00 6.26 C

ATOM 9011 CE2 PHE D 28 41.560 46.323 30.678 1.00 6.43 C

ATOM 9012 CD2 PHE D 28 42.153 45.212 30.064 1.00 6.12 C

ATOM 9013 C PHE D 28 40.806 42.796 28.307 1.00 6.31 C

ATOM 9014 O PHE D 28 41.208 43.321 27.273 1.00 6.22 O

ATOM 9015 N THR D 29 39.561 42.952 28.759 1.00 6.17 N

ATOM 9016 CA THR D 29 38.598 43.770 28.022 1.00 6.09 C

ATOM 9017 CB THR D 29 37.349 42.970 27.596 1.00 5.75 C

ATOM 9018 OGl THR D 29 36.613 42.557 28.754 1.00 5.72 O

ATOM 9019 CG2 THR D 29 37.747 41.750 26.779 1.00 5.56 C

ATOM 9020 C THR D 29 38.209 45.028 28.802 1.00 6.10 C

ATOM 9021 O THR D 29 37.831 44.953 29.974 1.00 5.68 O

ATOM 9022 N ASN D 30 38.300 46.176 28.135 1.00 6.30 N

ATOM 9023 CA ASN D 30 38.129 47.477 28.793 1.00 6.85 C

ATOM 9024 CB ASN D 30 38.929 48.579 28.061 1.00 7.09 C

ATOM 9025 CG ASN D 30 38.343 48.947 26.695 1.00 7.01 C

ATOM 9026 ODl ASN D 30 37.509 48.231 26.145 1.00 8.41 O

ATOM 9027 ND2 ASN D 30 38.796 50.066 26.141 1.00 6.90 N

ATOM 9028 C ASN D 30 36.670 47.900 29.033 1.00 7.01 C

ATOM 9029 O ASN D 30 36.406 49.026 29.459 1.00 6.85 O

ATOM 9030 N TRP D 31 35.735 46.995 28.751 1.00 7.53 N

ATOM 9031 CA TRP D 31 34.327 47.210 29.080 1.00 7.75 C

ATOM 9032 CB TRP D 31 33.423 46.914 27.881 1.00 8.15 C

ATOM 9033 CG TRP D 31 33.503 45.496 27.355 1.00 8.00 C

ATOM 9034 CDl TRP D 31 32.750 44.428 27.754 1.00 8.44 C

ATOM 9035 NEl TRP D 31 33.098 43.306 27.036 1.00 8.51 N

ATOM 9036 CE2 TRP D 31 34.086 43.638 26.145 1.00 7.89 C

ATOM 9037 CD2 TRP D 31 34.362 45.014 26.312 1.00 8.02 C

ATOM 9038 CE3 TRP D 31 35.349 45.609 25.511 1.00 7.91 C

ATOM 9039 CZ3 TRP D 31 36.017 44.822 24.578 1.00 8.49 C

ATOM 9040 CH2 TRP D 31 35.710 43.458 24.425 1.00 8.19 C

ATOM 9041 CZ2 TRP D 31 34.752 42.848 25.200 1.00 8.52 C

ATOM 9042 C TRP D 31 33.899 46.383 30.291 1.00 8.13 C

ATOM 9043 O TRP D 31 32.780 46.547 30.795 1.00 7.89 O

ATOM 9044 N ALA D 32 34.791 45.498 30.745 1.00 8.32 N

ATOM 9045 CA ALA D 32 34.561 44.686 31.946 1.00 9.01 C

ATOM 9046 CB ALA D 32 35.711 43.709 32.166 1.00 8.83 C

ATOM 9047 C ALA D 32 34.363 45.571 33.178 1.00 9.27 C

ATOM 9048 O ALA D 32 33.709 45.167 34.145 1.00 9.69 O

ATOM 9049 N GLN D 33 34.916 46.784 33.111 1.00 9.50 N

ATOM 9050 CA GLN D 33 34.801 47.791 34.173 1.00 9.66 C

ATOM 9051 CB GLN D 33 35.600 49.053 33.812 1.00 9.64 C W2025-7029WO / AM102903-PCT

ATOM 9052 CG GLN D 33 35.138 49.774 32.541 1.00 9.71 C

ATOM 9053 CD GLN D 33 35.752 51.152 32.390 1.00 9.77 C

ATOM 9054 OEl GLN D 33 35.561 52.028 33.237 1.00 10.37 O

ATOM 9055 NE2 GLN D 33 36.485 51.356 31.305 1.00 9.47 N

ATOM 9056 C GLN D 33 33.352 48.167 34.515 1.00 9.74 C

ATOM 9057 O GLN D 33 33.072 48.590 35.638 1.00 9.76 O

ATOM 9058 N TYR D 34 32.445 48.006 33.551 1.00 9.51 N

ATOM 9059 CA TYR D 34 31.056 48.437 33.717 1.00 9.82 C

ATOM 9060 CB TYR D 34 30.499 48.983 32.391 1.00 9.92 C

ATOM 9061 CG TYR D 34 31.286 50.153 31.836 1.00 10.19 C

ATOM 9062 CDl TYR D 34 31.354 51.367 32.529 1.00 10.39 C

ATOM 9063 CEl TYR D 34 32.073 52.445 32.027 1.00 10.48 C

ATOM 9064 CZ TYR D 34 32.738 52.318 30.815 1.00 10.54 C

ATOM 9065 OH TYR D 34 33.450 53.383 30.319 1.00 10.97 O

ATOM 9066 CE2 TYR D 34 32.688 51.125 30.104 1.00 10.28 C

ATOM 9067 CD2 TYR D 34 31.961 50.048 30.618 1.00 10.04 C

ATOM 9068 C TYR D 34 30.124 47.363 34.282 1.00 9.76 C

ATOM 9069 O TYR D 34 28.932 47.611 34.479 1.00 9.62 O

ATOM 9070 N ARG D 35 30.663 46.177 34.540 1.00 9.85 N

ATOM 9071 CA ARG D 35 29.856 45.074 35.053 1.00 10.02 C

ATOM 9072 CB ARG D 35 30.570 43.737 34.838 1.00 9.98 C

ATOM 9073 CG ARG D 35 30.713 43.361 33.373 1.00 9.74 C

ATOM 9074 CD ARG D 35 31.521 42.094 33.188 1.00 9.24 C

ATOM 9075 NE ARG D 35 31.668 41.803 31.768 1.00 9.30 N

ATOM 9076 CZ ARG D 35 32.655 41.090 31.235 1.00 8.50 C

ATOM 9077 NHl ARG D 35 33.612 40.573 31.998 1.00 6.88 N

ATOM 9078 NH2 ARG D 35 32.684 40.905 29.924 1.00 7.94 N

ATOM 9079 C ARG D 35 29.505 45.293 36.530 1.00 10.24 C

ATOM 9080 O ARG D 35 30.354 45.735 37.308 1.00 10.24 O

ATOM 9081 N PRO D 36 28.250 44.985 36.916 1.00 10.41 N

ATOM 9082 CA PRO D 36 27.779 45.237 38.282 1.00 10.47 C

ATOM 9083 CB PRO D 36 26.286 44.886 38.209 1.00 10.63 C

ATOM 9084 CG PRO D 36 26.175 43.915 37.072 1.00 10.73 C

ATOM 9085 CD PRO D 36 27.201 44.377 36.073 1.00 10.44 C

ATOM 9086 C PRO D 36 28.466 44.370 39.336 1.00 10.70 C

ATOM 9087 O PRO D 36 28.729 43.187 39.092 1.00 10.61 O

ATOM 9088 N GLY D 37 28.755 44.980 40.487 1.00 10.67 N

ATOM 9089 CA GLY D 37 29.269 44.290 41.674 1.00 10.77 C

ATOM 9090 C GLY D 37 30.457 43.380 41.437 1.00 11.01 C

ATOM 9091 O GLY D 37 31.520 43.832 41.020 1.00 10.93 O

ATOM 9092 N LEU D 38 30.258 42.090 41.699 1.00 11.04 N

ATOM 9093 CA LEU D 38 31.304 41.073 41.562 1.00 11.24 C

ATOM 9094 CB LEU D 38 30.803 39.726 42.088 1.00 11.36 C

ATOM 9095 CG LEU D 38 30.655 39.595 43.604 1.00 12.65 C

ATOM 9096 CDl LEU D 38 29.801 38.375 43.946 1.00 14.20 C

ATOM 9097 CD2 LEU D 38 32.021 39.523 44.280 1.00 13.10 C

ATOM 9098 C LEU D 38 31.870 40.900 40.147 1.00 10.91 C

ATOM 9099 O LEU D 38 32.971 40.366 39.985 1.00 11.14 O

ATOM 9100 N GLY D 39 31.125 41.356 39.142 1.00 10.37 N

ATOM 9101 CA GLY D 39 31.535 41.225 37.744 1.00 10.12 C

ATOM 9102 C GLY D 39 32.585 42.227 37.288 1.00 9.87 C

ATOM 9103 O GLY D 39 33.316 41.968 36.329 1.00 9.61 O

ATOM 9104 N ARG D 40 32.655 43.370 37.970 1.00 9.57 N

ATOM 9105 CA ARG D 40 33.610 44.431 37.633 1.00 9.52 C

ATOM 9106 CB ARG D 40 33.426 45.634 38.569 1.00 9.45 C

ATOM 9107 CG ARG D 40 34.425 46.777 38.365 1.00 9.74 C

ATOM 9108 CD ARG D 40 34.134 47.903 39.355 1.00 10.27 C

ATOM 9109 NE ARG D 40 35.204 48.898 39.439 1.00 12.58 N

ATOM 9110 CZ ARG D 40 35.304 49.966 38.651 1.00 13.22 C

ATOM 9111 NHl ARG D 40 36.304 50.820 38.816 1.00 12.41 N

ATOM 9112 NH2 ARG D 40 34.401 50.185 37.703 1.00 13.41 N

ATOM 9113 C ARG D 40 35.054 43.927 37.689 1.00 8.98 C

ATOM 9114 O ARG D 40 35.489 43.376 38.706 1.00 9.03 O W2025-7029WO / AM102903-PCT

ATOM 9115 N PHE D 41 35.783 44.120 36.589 1.00 8.66 N

ATOM 9116 CA PHE D 41 37.171 43.668 36.486 1.00 8.25 C

ATOM 9117 CB PHE D 41 37.276 42.431 35.577 1.00 8.14 C

ATOM 9118 CG PHE D 41 38.620 41.754 35.619 1.00 7.46 C

ATOM 9119 CDl PHE D 41 38.831 40.653 36.445 1.00 7.14 C

ATOM 9120 CEl PHE D 41 40.075 40.019 36.491 1.00 6.90 C

ATOM 9121 CZ PHE D 41 41.124 40.494 35.709 1.00 7.79 C

ATOM 9122 CE2 PHE D 41 40.924 41.595 34.876 1.00 6.54 C

ATOM 9123 CD2 PHE D 41 39.675 42.213 34.834 1.00 6.81 C

ATOM 9124 C PHE D 41 38.065 44.792 35.966 1.00 8.31 C

ATOM 9125 O PHE D 41 37.808 45.363 34.903 1.00 8.09 O

ATOM 9126 N MET D 42 39.117 45.090 36.729 1.00 8.46 N

ATOM 9127 CA MET D 42 40.059 46.159 36.414 1.00 8.61 C

ATOM 9128 CB MET D 42 40.052 47.224 37.525 1.00 8.64 C

ATOM 9129 CG MET D 42 38.675 47.807 37.836 1.00 9.11 C

ATOM 9130 SD MET D 42 37.970 48.746 36.473 1.00 10.37 S

ATOM 9131 CE MET D 42 38.840 50.299 36.641 1.00 8.66 C

ATOM 9132 C MET D 42 41.460 45.571 36.249 1.00 8.74 C

ATOM 9133 O MET D 42 41.712 44.455 36.709 1.00 8.49 O

ATOM 9134 N PRO D 43 42.381 46.313 35.598 1.00 8.91 N

ATOM 9135 CA PRO D 43 43.713 45.746 35.373 1.00 9.32 C

ATOM 9136 CB PRO D 43 44.498 46.910 34.750 1.00 9.30 C

ATOM 9137 CG PRO D 43 43.454 47.759 34.116 1.00 8.65 C

ATOM 9138 CD PRO D 43 42.268 47.672 35.031 1.00 8.88 C

ATOM 9139 C PRO D 43 44.390 45.248 36.652 1.00 9.90 C

ATOM 9140 O PRO D 43 45.115 44.256 36.601 1.00 9.66 O

ATOM 9141 N ASP D 44 44.129 45.899 37.786 1.00 10.44 N

ATOM 9142 CA ASP D 44 44.749 45.496 39.056 1.00 11.15 C

ATOM 9143 CB ASP D 44 44.737 46.650 40.074 1.00 11.82 C

ATOM 9144 CG ASP D 44 45.715 47.776 39.706 1.00 13.59 C

ATOM 9145 ODl ASP D 44 46.762 47.504 39.081 1.00 15.01 O

ATOM 9146 OD2 ASP D 44 45.440 48.945 40.051 1.00 16.52 O

ATOM 9147 C ASP D 44 44.167 44.207 39.652 1.00 10.84 C

ATOM 9148 O ASP D 44 44.677 43.693 40.652 1.00 10.62 O

ATOM 9149 N ASP D 45 43.113 43.687 39.022 1.00 10.63 N

ATOM 9150 CA ASP D 45 42.567 42.362 39.338 1.00 10.41 C

ATOM 9151 CB ASP D 45 41.081 42.300 38.982 1.00 10.50 C

ATOM 9152 CG ASP D 45 40.232 43.214 39.852 1.00 10.87 C

ATOM 9153 ODl ASP D 45 40.342 43.133 41.095 1.00 11.01 O

ATOM 9154 OD2 ASP D 45 39.456 44.013 39.290 1.00 10.73 O

ATOM 9155 C ASP D 45 43.330 41.223 38.637 1.00 10.21 C

ATOM 9156 O ASP D 45 43.092 40.045 38.913 1.00 9.92 O

ATOM 9157 N ILE D 46 44.236 41.582 37.731 1.00 10.05 N

ATOM 9158 CA ILE D 46 45.082 40.607 37.034 1.00 9.95 C

ATOM 9159 CB ILE D 46 45.645 41.181 35.697 1.00 10.02 C

ATOM 9160 CGl ILE D 46 44.506 41.503 34.723 1.00 9.40 C

ATOM 9161 CDl ILE D 46 44.899 42.445 33.599 1.00 9.77 C

ATOM 9162 CG2 ILE D 46 46.661 40.216 35.052 1.00 9.15 C

ATOM 9163 C ILE D 46 46.243 40.167 37.924 1.00 10.31 C

ATOM 9164 O ILE D 46 46.985 41.001 38.437 1.00 10.23 O

ATOM 9165 N ASN D 47 46.382 38.858 38.117 1.00 10.50 N

ATOM 9166 CA ASN D 47 47.574 38.298 38.745 1.00 10.79 C

ATOM 9167 CB ASN D 47 47.292 36.864 39.209 1.00 10.78 C

ATOM 9168 CG ASN D 47 48.505 36.180 39.835 1.00 11.52 C

ATOM 9169 ODl ASN D 47 49.572 36.769 39.991 1.00 11.82 O

ATOM 9170 ND2 ASN D 47 48.332 34.914 40.197 1.00 12.57 N

ATOM 9171 C ASN D 47 48.740 38.357 37.741 1.00 10.87 C

ATOM 9172 O ASN D 47 48.690 37.704 36.695 1.00 10.95 O

ATOM 9173 N PRO D 48 49.785 39.153 38.047 1.00 10.97 N

ATOM 9174 CA PRO D 48 50.867 39.371 37.078 1.00 11.04 C

ATOM 9175 CB PRO D 48 51.725 40.455 37.741 1.00 11.04 C

ATOM 9176 CG PRO D 48 51.429 40.360 39.181 1.00 11.40 C

ATOM 9177 CD PRO D 48 50.007 39.902 39.299 1.00 11.16 C W2025-7029WO / AM102903-PCT

ATOM 9178 C PRO D 48 51.706 38.129 36.770 1.00 11.01 C

ATOM 9179 O PRO D 48 52.447 38.120 35.783 1.00 10.97 O

ATOM 9180 N CYS D 49 51.573 37.096 37.600 1.00 10.95 N

ATOM 9181 CA CYS D 49 52.336 35.862 37.435 1.00 10.87 C

ATOM 9182 CB CYS D 49 52.912 35.426 38.784 1.00 10.82 C

ATOM 9183 SG CYS D 49 54.142 36.593 39.386 1.00 11.47 S

ATOM 9184 C CYS D 49 51.560 34.719 36.768 1.00 10.60 C

ATOM 9185 O CYS D 49 52.028 33.575 36.750 1.00 10.84 O

ATOM 9186 N LEU D 50 50.394 35.030 36.206 1.00 10.34 N

ATOM 9187 CA LEU D 50 49.586 34.027 35.504 1.00 10.20 C

ATOM 9188 CB LEU D 50 48.094 34.329 35.632 1.00 10.28 C

ATOM 9189 CG LEU D 50 47.342 33.818 36.858 1.00 11.52 C

ATOM 9190 CDl LEU D 50 45.957 34.401 36.826 1.00 12.30 C

ATOM 9191 CD2 LEU D 50 47.275 32.281 36.897 1.00 12.62 C

ATOM 9192 C LEU D 50 49.938 33.848 34.029 1.00 9.79 C

ATOM 9193 O LEU D 50 50.120 32.721 33.568 1.00 9.94 O

ATOM 9194 N CYS D 51 50.015 34.955 33.295 1.00 9.22 N

ATOM 9195 CA CYS D 51 50.227 34.918 31.848 1.00 9.04 C

ATOM 9196 CB CYS D 51 49.107 35.684 31.130 1.00 9.19 C

ATOM 9197 SG CYS D 51 47.439 35.364 31.767 1.00 9.36

ATOM 9198 C CYS D 51 51.594 35.490 31.453 1.00 8.64 C

ATOM 9199 O CYS D 51 52.164 36.317 32.175 1.00 8.69 O

ATOM 9200 N THR D 52 52.113 35.049 30.308 1.00 8.17 N

ATOM 9201 CA THR D 52 53.370 35.595 29.768 1.00 7.80 C

ATOM 9202 CB THR D 52 54.148 34.555 28.920 1.00 7.75 C

ATOM 9203 OGl THR D 52 53.328 34.095 27.837 1.00 7.31 O

ATOM 9204 CG2 THR D 52 54.568 33.365 29.782 1.00 8.08 C

ATOM 9205 C THR D 52 53.138 36.854 28.932 1.00 7.75 C

ATOM 9206 O THR D 52 53.998 37.743 28.874 1.00 7.30 O

ATOM 9207 N HIS D 53 51.985 36.902 28.266 1.00 7.41 N

ATOM 9208 CA HIS D 53 51.579 38.036 27.445 1.00 7.46 C

ATOM 9209 CB HIS D 53 51.532 37.646 25.966 1.00 7.68 C

ATOM 9210 CG HIS D 53 52.871 37.590 25.295 1.00 8.70 C

ATOM 9211 NDl HIS D 53 54.057 37.513 25.991 1.00 10.42 N

ATOM 9212 CEl HIS D 53 55.065 37.463 25.138 1.00 10.03 C

ATOM 9213 NE2 HIS D 53 54.576 37.495 23.913 1.00 10.18 N

ATOM 9214 CD2 HIS D 53 53.204 37.561 23.983 1.00 9.96 C

ATOM 9215 C HIS D 53 50.193 38.494 27.872 1.00 7.32 C

ATOM 9216 O HIS D 53 49.295 37.675 28.070 1.00 7.08 O

ATOM 9217 N LEU D 54 50.027 39.802 28.023 1.00 7.26 N

ATOM 9218 CA LEU D 54 48.729 40.380 28.334 1.00 7.09 C

ATOM 9219 CB LEU D 54 48.779 41.127 29.673 1.00 7.15 C

ATOM 9220 CG LEU D 54 48.826 40.324 30.982 1.00 6.64 C

ATOM 9221 CDl LEU D 54 48.870 41.254 32.181 1.00 6.92 C

ATOM 9222 CD2 LEU D 54 47.645 39.369 31.112 1.00 7.83 C

ATOM 9223 C LEU D 54 48.326 41.314 27.201 1.00 6.92 C

ATOM 9224 O LEU D 54 49.128 42.148 26.778 1.00 7.01 O

ATOM 9225 N ILE D 55 47.103 41.157 26.693 1.00 6.52 N

ATOM 9226 CA ILE D 55 46.611 41.980 25.575 1.00 6.34 C

ATOM 9227 CB ILE D 55 46.292 41.142 24.296 1.00 6.54 C

ATOM 9228 CGl ILE D 55 47.471 40.231 23.931 1.00 5.86 C

ATOM 9229 CDl ILE D 55 47.369 39.568 22.572 1.00 6.54 C

ATOM 9230 CG2 ILE D 55 45.944 42.066 23.114 1.00 6.28 C

ATOM 9231 C ILE D 55 45.395 42.830 25.982 1.00 6.47 C

ATOM 9232 O ILE D 55 44.412 42.315 26.529 1.00 6.13 O

ATOM 9233 N TYR D 56 45.487 44.129 25.704 1.00 6.31 N

ATOM 9234 CA TYR D 56 44.453 45.107 26.038 1.00 6.46 C

ATOM 9235 CB TYR D 56 45.121 46.455 26.370 1.00 6.48 C

ATOM 9236 CG TYR D 56 44.234 47.458 27.077 1.00 6.18 C

ATOM 9237 CDl TYR D 56 44.346 47.666 28.449 1.00 6.31 C

ATOM 9238 CEl TYR D 56 43.535 48.590 29.105 1.00 6.48 C

ATOM 9239 CZ TYR D 56 42.605 49.316 28.383 1.00 6.67 C

ATOM 9240 OH TYR D 56 41.805 50.232 29.018 1.00 6.34 O W2025-7029WO / AM102903-PCT

ATOM 9241 CE2 TYR D 56 42.474 49.130 27.015 1.00 6.70 C

ATOM 9242 CD2 TYR D 56 43.292 48.210 26.370 1.00 6.42 C

ATOM 9243 C TYR D 56 43.463 45.277 24.879 1.00 6.32 C

ATOM 9244 O TYR D 56 43.833 45.744 23.800 1.00 6.34 O

ATOM 9245 N ALA D 57 42.205 44.907 25.115 1.00 6.27 N

ATOM 9246 CA ALA D 57 41.156 45.030 24.106 1.00 6.28 C

ATOM 9247 CB ALA D 57 40.514 43.663 23.866 1.00 6.38 C

ATOM 9248 C ALA D 57 40.091 46.057 24.532 1.00 6.18 C

ATOM 9249 O ALA D 57 39.555 45.939 25.628 1.00 6.03 O

ATOM 9250 N PHE D 58 39.771 47.061 23.707 1.00 6.09 N

ATOM 9251 CA PHE D 58 40.399 47.364 22.415 1.00 6.25 C

ATOM 9252 CB PHE D 58 39.451 47.033 21.247 1.00 6.09 C

ATOM 9253 CG PHE D 58 39.166 45.565 21.068 1.00 5.87 C

ATOM 9254 CDl PHE D 58 37.911 45.050 21.384 1.00 5.97 C

ATOM 9255 CEl PHE D 58 37.628 43.694 21.219 1.00 5.39 C

ATOM 9256 CZ PHE D 58 38.609 42.835 20.723 1.00 5.87 C

ATOM 9257 CE2 PHE D 58 39.867 43.336 20.398 1.00 4.75 C

ATOM 9258 CD2 PHE D 58 40.137 44.704 20.567 1.00 5.58 C

ATOM 9259 C PHE D 58 40.742 48.862 22.295 1.00 6.36 C

ATOM 9260 O PHE D 58 40.137 49.715 22.954 1.00 6.33 O

ATOM 9261 N ALA D 59 41.697 49.171 21.422 1.00 6.51 N

ATOM 9262 CA ALA D 59 41.896 50.530 20.941 1.00 6.57 C

ATOM 9263 CB ALA D 59 43.363 50.764 20.593 1.00 6.44 C

ATOM 9264 C ALA D 59 40.996 50.783 19.719 1.00 6.74 C

ATOM 9265 O ALA D 59 40.503 49.841 19.083 1.00 6.45 O

ATOM 9266 N GLY D 60 40.785 52.057 19.407 1.00 6.91 N

ATOM 9267 CA GLY D 60 39.988 52.457 18.252 1.00 7.37 C

ATOM 9268 C GLY D 60 40.803 53.144 17.180 1.00 7.66 C

ATOM 9269 O GLY D 60 42.038 53.111 17.205 1.00 7.55 O

ATOM 9270 N MET D 61 40.107 53.762 16.228 1.00 8.14 N

ATOM 9271 CA MET D 61 40.768 54.468 15.134 1.00 8.68 C

ATOM 9272 CB MET D 61 40.942 53.542 13.925 1.00 8.54 C

ATOM 9273 CG MET D 61 42.023 53.950 12.925 1.00 8.25 C

ATOM 9274 SD MET D 61 41.804 53.119 11.329 1.00 9.04

ATOM 9275 CE MET D 61 42.389 51.459 11.680 1.00 8.55 C

ATOM 9276 C MET D 61 39.978 55.720 14.746 1.00 9.27 C

ATOM 9277 O MET D 61 38.751 55.674 14.616 1.00 9.02 O

ATOM 9278 N GLN D 62 40.697 56.832 14.587 1.00 9.69 N

ATOM 9279 CA GLN D 62 40.140 58.092 14.087 1.00 10.42 C

ATOM 9280 CB GLN D 62 40.002 59.122 15.208 1.00 10.62 C

ATOM 9281 CG GLN D 62 38.685 59.088 15.971 1.00 11.69 C

ATOM 9282 CD GLN D 62 38.536 60.267 16.938 1.00 11.97 C

ATOM 9283 OEl GLN D 62 38.897 61.415 16.625 1.00 13.94 O

ATOM 9284 NE2 GLN D 62 37.995 59.987 18.118 1.00 13.38 N

ATOM 9285 C GLN D 62 41.073 58.648 13.021 1.00 10.02 C

ATOM 9286 O GLN D 62 42.272 58.822 13.270 1.00 9.88 O

ATOM 9287 N ASN D 63 40.524 58.914 11.838 1.00 9.97 N

ATOM 9288 CA ASN D 63 41.288 59.480 10.723 1.00 10.30 C

ATOM 9289 CB ASN D 63 41.514 60.987 10.933 1.00 10.47 C

ATOM 9290 CG ASN D 63 40.218 61.762 11.034 1.00 11.87 C

ATOM 9291 ODl ASN D 63 39.379 61.699 10.137 1.00 11.77 O

ATOM 9292 ND2 ASN D 63 40.049 62.508 12.130 1.00 13.12 N

ATOM 9293 C ASN D 63 42.613 58.748 10.486 1.00 10.05 C

ATOM 9294 O ASN D 63 43.677 59.375 10.384 1.00 9.99 O

ATOM 9295 N ASN D 64 42.525 57.415 10.428 1.00 9.70 N

ATOM 9296 CA ASN D 64 43.660 56.523 10.171 1.00 9.73 C

ATOM 9297 CB ASN D 64 44.254 56.785 8.775 1.00 9.63 C

ATOM 9298 CG ASN D 64 43.246 56.548 7.671 1.00 9.58 C

ATOM 9299 ODl ASN D 64 42.752 55.435 7.505 1.00 10.09 O

ATOM 9300 ND2 ASN D 64 42.917 57.600 6.921 1.00 8.32 N

ATOM 9301 C ASN D 64 44.745 56.522 11.255 1.00 9.86 C

ATOM 9302 O ASN D 64 45.876 56.110 11.007 1.00 9.85 O

ATOM 9303 N GLU D 65 44.390 56.981 12.454 1.00 9.89 N W2025-7029WO / AM102903-PCT

ATOM 9304 CA GLU D 65 45.301 56.966 13.593 1.00 10.23 C

ATOM 9305 CB GLU D 65 45.633 58.396 14.052 1.00 10.10 C

ATOM 9306 CG GLU D 65 46.392 59.245 13.023 1.00 10.96 C

ATOM 9307 CD GLU D 65 46.707 60.670 13.504 1.00 12.22 C

ATOM 9308 OEl GLU D 65 47.649 61.284 12.959 1.00 14.66 O

ATOM 9309 OE2 GLU D 65 46.020 61.187 14.417 1.00 15.45 O

ATOM 9310 C GLU D 65 44.696 56.160 14.738 1.00 9.74 C

ATOM 9311 O GLU D 65 43.496 56.250 15.000 1.00 9.69 O

ATOM 9312 N ILE D 66 45.525 55.363 15.410 1.00 9.63 N

ATOM 9313 CA ILE D 66 45.092 54.623 16.600 1.00 9.32 C

ATOM 9314 CB ILE D 66 46.186 53.634 17.098 1.00 9.46 C

ATOM 9315 CGl ILE D 66 45.608 52.655 18.138 1.00 8.87 C

ATOM 9316 CDl ILE D 66 46.412 51.369 18.317 1.00 8.57 C

ATOM 9317 CG2 ILE D 66 47.414 54.398 17.619 1.00 8.22 C

ATOM 9318 C ILE D 66 44.658 55.568 17.736 1.00 9.66 C

ATOM 9319 O ILE D 66 45.239 56.636 17.934 1.00 9.43 O

ATOM 9320 N THR D 67 43.635 55.171 18.484 1.00 9.99 N

ATOM 9321 CA THR D 67 43.093 56.049 19.518 1.00 10.79 C

ATOM 9322 CB THR D 67 42.041 57.037 18.906 1.00 10.98 C

ATOM 9323 OGl THR D 67 41.817 58.134 19.800 1.00 14.16 O

ATOM 9324 CG2 THR D 67 40.720 56.341 18.613 1.00 10.69 C

ATOM 9325 C THR D 67 42.504 55.269 20.695 1.00 10.41 C

ATOM 9326 O THR D 67 42.131 54.106 20.552 1.00 10.48 O

ATOM 9327 N THR D 68 42.432 55.916 21.854 1.00 10.41 N

ATOM 9328 CA THR D 68 41.681 55.391 22.994 1.00 10.02 C

ATOM 9329 CB THR D 68 41.877 56.258 24.263 1.00 10.21 C

ATOM 9330 OGl THR D 68 41.427 57.592 24.004 1.00 9.34 O

ATOM 9331 CG2 THR D 68 43.341 56.281 24.719 1.00 9.62 C

ATOM 9332 C THR D 68 40.185 55.362 22.656 1.00 10.23 C

ATOM 9333 O THR D 68 39.746 55.961 21.670 1.00 9.62 O

ATOM 9334 N ILE D 69 39.406 54.678 23.488 1.00 10.61 N

ATOM 9335 CA ILE D 69 37.968 54.557 23.279 1.00 11.32 C

ATOM 9336 CB ILE D 69 37.600 53.153 22.726 1.00 11.63 C

ATOM 9337 CGl ILE D 69 37.734 53.155 21.198 1.00 12.07 C

ATOM 9338 CDl ILE D 69 37.207 51.914 20.520 1.00 13.50 C

ATOM 9339 CG2 ILE D 69 36.190 52.726 23.156 1.00 12.61 C

ATOM 9340 C ILE D 69 37.178 54.891 24.547 1.00 11.44 C

ATOM 9341 O ILE D 69 36.087 55.466 24.474 1.00 11.95 O

ATOM 9342 N GLU D 70 37.738 54.541 25.702 1.00 10.91 N

ATOM 9343 CA GLU D 70 37.091 54.811 26.979 1.00 10.79 C

ATOM 9344 CB GLU D 70 37.141 53.572 27.898 1.00 10.90 C

ATOM 9345 CG GLU D 70 36.359 52.357 27.384 1.00 11.75 C

ATOM 9346 CD GLU D 70 34.846 52.592 27.299 1.00 14.16 C

ATOM 9347 OEl GLU D 70 34.166 51.847 26.552 1.00 14.41 O

ATOM 9348 OE2 GLU D 70 34.333 53.515 27.971 1.00 13.76 O

ATOM 9349 C GLU D 70 37.691 56.028 27.680 1.00 10.24 C

ATOM 9350 O GLU D 70 38.874 56.337 27.516 1.00 10.06 O

ATOM 9351 N TRP D 71 36.846 56.707 28.453 1.00 9.57 N

ATOM 9352 CA TRP D 71 37.200 57.881 29.255 1.00 9.11 C

ATOM 9353 CB TRP D 71 35.987 58.289 30.100 1.00 9.30 C

ATOM 9354 CG TRP D 71 35.641 57.244 31.121 1.00 9.43 C

ATOM 9355 CDl TRP D 71 34.988 56.069 30.898 1.00 9.25 C

ATOM 9356 NEl TRP D 71 34.875 55.358 32.068 1.00 8.73 N

ATOM 9357 CE2 TRP D 71 35.474 56.063 33.077 1.00 9.20 C

ATOM 9358 CD2 TRP D 71 35.972 57.261 32.517 1.00 9.18 C

ATOM 9359 CE3 TRP D 71 36.636 58.175 33.348 1.00 10.19 C

ATOM 9360 CZ3 TRP D 71 36.778 57.867 34.703 1.00 9.69 C

ATOM 9361 CH2 TRP D 71 36.269 56.664 35.230 1.00 10.00 C

ATOM 9362 CZ2 TRP D 71 35.615 55.752 34.434 1.00 9.95 C

ATOM 9363 C TRP D 71 38.413 57.670 30.177 1.00 8.63 C

ATOM 9364 O TRP D 71 39.131 58.623 30.486 1.00 8.48 O

ATOM 9365 N ASN D 72 38.626 56.430 30.621 1.00 8.21 N

ATOM 9366 CA ASN D 72 39.736 56.102 31.532 1.00 7.84 C W2025-7029WO / AM102903-PCT

ATOM 9367 CB ASN D 72 39.195 55.560 32.866 1.00 7.82 C

ATOM 9368 CG ASN D 72 38.403 54.275 32.705 1.00 7.71 C

ATOM 9369 ODl ASN D 72 37.928 53.941 31.609 1.00 7.54 O

ATOM 9370 ND2 ASN D 72 38.242 53.547 33.811 1.00 6.39 N

ATOM 9371 C ASN D 72 40.802 55.151 30.962 1.00 7.65 C

ATOM 9372 O ASN D 72 41.638 54.631 31.710 1.00 7.74 O

ATOM 9373 N ASP D 73 40.773 54.935 29.646 1.00 7.39 N

ATOM 9374 CA ASP D 73 41.746 54.065 28.967 1.00 7.22 C

ATOM 9375 CB ASP D 73 41.621 54.162 27.441 1.00 6.93 C

ATOM 9376 CG ASP D 73 40.735 53.072 26.843 1.00 6.96 C

ATOM 9377 ODl ASP D 73 40.542 52.013 27.485 1.00 6.63 O

ATOM 9378 OD2 ASP D 73 40.244 53.268 25.707 1.00 7.13 O

ATOM 9379 C ASP D 73 43.191 54.323 29.378 1.00 7.23 C

ATOM 9380 O ASP D 73 43.918 53.381 29.682 1.00 6.90 O

ATOM 9381 N VAL D 74 43.607 55.590 29.392 1.00 7.53 N

ATOM 9382 CA VAL D 74 45.001 55.906 29.714 1.00 7.99 C

ATOM 9383 CB VAL D 74 45.373 57.390 29.428 1.00 8.44 C

ATOM 9384 CGl VAL D 74 46.844 57.655 29.795 1.00 8.50 C

ATOM 9385 CG2 VAL D 74 45.137 57.728 27.947 1.00 8.79 C

ATOM 9386 C VAL D 74 45.354 55.491 31.151 1.00 7.81 C

ATOM 9387 O VAL D 74 46.440 54.967 31.402 1.00 7.76 O

ATOM 9388 N THR D 75 44.422 55.710 32.076 1.00 7.99 N

ATOM 9389 CA THR D 75 44.577 55.279 33.472 1.00 7.75 C

ATOM 9390 CB THR D 75 43.398 55.781 34.338 1.00 7.90 C

ATOM 9391 OGl THR D 75 43.357 57.212 34.283 1.00 8.34 O

ATOM 9392 CG2 THR D 75 43.536 55.325 35.798 1.00 7.93 C

ATOM 9393 C THR D 75 44.700 53.755 33.537 1.00 7.50 C

ATOM 9394 O THR D 75 45.567 53.218 34.229 1.00 7.30 O

ATOM 9395 N LEU D 76 43.846 53.071 32.784 1.00 7.33 N

ATOM 9396 CA LEU D 76 43.921 51.619 32.663 1.00 6.89 C

ATOM 9397 CB LEU D 76 42.669 51.052 31.978 1.00 6.45 C

ATOM 9398 CG LEU D 76 41.291 51.448 32.544 1.00 6.33 C

ATOM 9399 CDl LEU D 76 40.154 50.799 31.757 1.00 5.37 C

ATOM 9400 CD2 LEU D 76 41.154 51.153 34.028 1.00 4.51 C

ATOM 9401 C LEU D 76 45.206 51.139 31.976 1.00 6.86 C

ATOM 9402 O LEU D 76 45.791 50.153 32.419 1.00 6.61 O

ATOM 9403 N TYR D 77 45.650 51.833 30.922 1.00 7.11 N

ATOM 9404 CA TYR D 77 46.929 51.504 30.253 1.00 7.49 C

ATOM 9405 CB TYR D 77 47.305 52.523 29.167 1.00 7.35 C

ATOM 9406 CG TYR D 77 46.468 52.583 27.901 1.00 7.22 C

ATOM 9407 CDl TYR D 77 45.529 51.599 27.582 1.00 6.88 C

ATOM 9408 CEl TYR D 77 44.777 51.683 26.402 1.00 6.60 C

ATOM 9409 CZ TYR D 77 44.988 52.741 25.527 1.00 6.62 C

ATOM 9410 OH TYR D 77 44.267 52.837 24.366 1.00 7.14 O

ATOM 9411 CE2 TYR D 77 45.922 53.718 25.815 1.00 7.07 C

ATOM 9412 CD2 TYR D 77 46.665 53.626 26.987 1.00 7.08 C

ATOM 9413 C TYR D 77 48.080 51.485 31.250 1.00 7.98 C

ATOM 9414 O TYR D 77 48.928 50.583 31.225 1.00 8.20 O

ATOM 9415 N GLN D 78 48.112 52.502 32.112 1.00 8.36 N

ATOM 9416 CA GLN D 78 49.197 52.690 33.079 1.00 9.06 C

ATOM 9417 CB GLN D 78 49.138 54.097 33.702 1.00 9.11 C

ATOM 9418 CG GLN D 78 49.535 55.210 32.731 1.00 10.58 C

ATOM 9419 CD GLN D 78 49.311 56.614 33.272 1.00 10.60 C

ATOM 9420 OEl GLN D 78 48.640 56.811 34.286 1.00 14.53 O

ATOM 9421 NE2 GLN D 78 49.866 57.604 32.580 1.00 12.61 N

ATOM 9422 C GLN D 78 49.188 51.611 34.158 1.00 8.39 C

ATOM 9423 O GLN D 78 50.244 51.088 34.528 1.00 8.35 O

ATOM 9424 N ALA D 79 47.994 51.277 34.648 1.00 8.05 N

ATOM 9425 CA ALA D 79 47.815 50.164 35.579 1.00 7.49 C

ATOM 9426 CB ALA D 79 46.372 50.120 36.098 1.00 7.52 C

ATOM 9427 C ALA D 79 48.192 48.837 34.916 1.00 7.18 C

ATOM 9428 O ALA D 79 48.925 48.040 35.498 1.00 7.32 O

ATOM 9429 N PHE D 80 47.697 48.630 33.694 1.00 6.70 N W2025-7029WO / AM102903-PCT

ATOM 9430 CA PHE D 80 47.929 47.414 32.898 1.00 6.61 C

ATOM 9431 CB PHE D 80 47.198 47.555 31.555 1.00 6.50 C

ATOM 9432 CG PHE D 80 47.049 46.272 30.770 1.00 6.55 C

ATOM 9433 CDl PHE D 80 47.731 46.098 29.570 1.00 5.76 C

ATOM 9434 CEl PHE D 80 47.577 44.930 28.816 1.00 6.22 C

ATOM 9435 CZ PHE D 80 46.713 43.930 29.252 1.00 5.58 C

ATOM 9436 CE2 PHE D 80 46.012 44.098 30.445 1.00 7.10 C

ATOM 9437 CD2 PHE D 80 46.178 45.267 31.197 1.00 6.58 C

ATOM 9438 C PHE D 80 49.420 47.175 32.650 1.00 6.49 C

ATOM 9439 O PHE D 80 49.939 46.094 32.934 1.00 6.28 O

ATOM 9440 N ASN D 81 50.100 48.188 32.120 1.00 6.37 N

ATOM 9441 CA ASN D 81 51.521 48.066 31.797 1.00 6.65 C

ATOM 9442 CB ASN D 81 51.945 49.102 30.749 1.00 6.35 C

ATOM 9443 CG ASN D 81 51.242 48.904 29.407 1.00 6.94 C

ATOM 9444 ODl ASN D 81 50.997 47.780 28.980 1.00 7.07 O

ATOM 9445 ND2 ASN D 81 50.919 50.006 28.737 1.00 6.90 N

ATOM 9446 C ASN D 81 52.396 48.132 33.045 1.00 6.56 C

ATOM 9447 O ASN D 81 53.511 47.622 33.045 1.00 6.75 O

ATOM 9448 N GLY D 82 51.865 48.738 34.108 1.00 6.58 N

ATOM 9449 CA GLY D 82 52.529 48.775 35.414 1.00 6.73 C

ATOM 9450 C GLY D 82 52.716 47.409 36.052 1.00 6.97 C

ATOM 9451 O GLY D 82 53.588 47.236 36.913 1.00 7.18 O

ATOM 9452 N LEU D 83 51.895 46.442 35.637 1.00 6.96 N

ATOM 9453 CA LEU D 83 52.018 45.038 36.066 1.00 7.16 C

ATOM 9454 CB LEU D 83 50.913 44.180 35.433 1.00 7.16 C

ATOM 9455 CG LEU D 83 49.468 44.449 35.883 1.00 7.17 C

ATOM 9456 CDl LEU D 83 48.493 43.674 35.024 1.00 7.07 C

ATOM 9457 CD2 LEU D 83 49.256 44.120 37.370 1.00 7.50 C

ATOM 9458 C LEU D 83 53.389 44.422 35.756 1.00 7.50 C

ATOM 9459 O LEU D 83 53.825 43.476 36.427 1.00 7.10 O

ATOM 9460 N LYS D 84 54.057 44.967 34.743 1.00 7.47 N

ATOM 9461 CA LYS D 84 55.406 44.541 34.372 1.00 8.05 C

ATOM 9462 CB LYS D 84 55.801 45.155 33.028 1.00 7.77 C

ATOM 9463 CG LYS D 84 54.984 44.609 31.851 1.00 7.18 C

ATOM 9464 CD LYS D 84 55.535 45.074 30.505 1.00 7.52 C

ATOM 9465 CE LYS D 84 55.024 46.458 30.114 1.00 5.09 C

ATOM 9466 NZ LYS D 84 55.858 47.035 29.010 1.00 6.22 N

ATOM 9467 C LYS D 84 56.455 44.843 35.448 1.00 8.91 C

ATOM 9468 O LYS D 84 57.541 44.264 35.438 1.00 9.06 O

ATOM 9469 N ASN D 85 56.124 45.740 36.378 1.00 9.67 N

ATOM 9470 CA ASN D 85 56.990 46.007 37.531 1.00 10.71 C

ATOM 9471 CB ASN D 85 56.609 47.329 38.203 1.00 11.01 C

ATOM 9472 CG ASN D 85 56.747 48.517 37.264 1.00 12.58 C

ATOM 9473 ODl ASN D 85 57.627 48.545 36.405 1.00 14.47 O

ATOM 9474 ND2 ASN D 85 55.871 49.499 37.420 1.00 13.90 N

ATOM 9475 C ASN D 85 56.998 44.861 38.543 1.00 10.80 C

ATOM 9476 O ASN D 85 57.936 44.720 39.334 1.00 10.68 O

ATOM 9477 N LYS D 86 55.958 44.036 38.483 1.00 10.86 N

ATOM 9478 CA LYS D 86 55.798 42.889 39.372 1.00 11.17 C

ATOM 9479 CB LYS D 86 54.342 42.797 39.848 1.00 11.24 C

ATOM 9480 CG LYS D 86 53.900 44.039 40.618 1.00 11.86 C

ATOM 9481 CD LYS D 86 52.440 44.006 41.026 1.00 12.34 C

ATOM 9482 CE LYS D 86 52.045 45.354 41.625 1.00 14.96 C

ATOM 9483 NZ LYS D 86 50.925 45.238 42.597 1.00 15.68 N

ATOM 9484 C LYS D 86 56.255 41.580 38.723 1.00 10.86 C

ATOM 9485 O LYS D 86 56.647 40.636 39.422 1.00 11.00 O

ATOM 9486 N ASN D 87 56.197 41.530 37.391 1.00 10.36 N

ATOM 9487 CA ASN D 87 56.708 40.397 36.623 1.00 10.04 C

ATOM 9488 CB ASN D 87 55.571 39.421 36.261 1.00 10.10 C

ATOM 9489 CG ASN D 87 56.056 38.206 35.459 1.00 9.73 C

ATOM 9490 ODl ASN D 87 57.249 37.911 35.406 1.00 9.12 O

ATOM 9491 ND2 ASN D 87 55.118 37.498 34.836 1.00 9.30 N

ATOM 9492 C ASN D 87 57.446 40.869 35.373 1.00 9.76 C W2025-7029WO / AM102903-PCT

ATOM 9493 O ASN D 87 56.818 41.205 34.366 1.00 9.88 O

ATOM 9494 N SER D 88 58.778 40.877 35.440 1.00 9.16 N

ATOM 9495 CA SER D 88 59.621 41.381 34.349 1.00 8.84 C

ATOM 9496 CB SER D 88 61.082 41.477 34.800 1.00 8.79 C

ATOM 9497 OG SER D 88 61.715 40.211 34.762 1.00 8.41 O

ATOM 9498 C SER D 88 59.541 40.582 33.044 1.00 8.63 C

ATOM 9499 O SER D 88 59.876 41.099 31.977 1.00 8.50 O

ATOM 9500 N GLN D 89 59.120 39.322 33.137 1.00 8.37 N

ATOM 9501 CA GLN D 89 58.982 38.446 31.973 1.00 8.14 C

ATOM 9502 CB GLN D 89 58.861 36.990 32.428 1.00 8.26 C

ATOM 9503 CG GLN D 89 59.091 35.949 31.336 1.00 8.04 C

ATOM 9504 CD GLN D 89 58.916 34.534 31.852 1.00 8.00 C

ATOM 9505 OEl GLN D 89 57.805 34.008 31.897 1.00 7.88 O

ATOM 9506 NE2 GLN D 89 60.018 33.916 32.258 1.00 6.94 N

ATOM 9507 C GLN D 89 57.768 38.825 31.123 1.00 8.26 C

ATOM 9508 O GLN D 89 57.751 38.603 29.912 1.00 7.86 O

ATOM 9509 N LEU D 90 56.760 39.390 31.783 1.00 8.37 N

ATOM 9510 CA LEU D 90 55.512 39.826 31.153 1.00 8.54 C

ATOM 9511 CB LEU D 90 54.594 40.419 32.229 1.00 8.62 C

ATOM 9512 CG LEU D 90 53.166 40.869 31.925 1.00 9.15 C

ATOM 9513 CDl LEU D 90 52.364 39.725 31.317 1.00 8.38 C

ATOM 9514 CD2 LEU D 90 52.515 41.389 33.213 1.00 8.28 C

ATOM 9515 C LEU D 90 55.729 40.847 30.037 1.00 8.64 C

ATOM 9516 O LEU D 90 56.471 41.814 30.204 1.00 8.43 O

ATOM 9517 N LYS D 91 55.092 40.604 28.896 1.00 8.64 N

ATOM 9518 CA LYS D 91 55.034 41.569 27.802 1.00 9.11 C

ATOM 9519 CB LYS D 91 55.644 40.990 26.529 1.00 9.20 C

ATOM 9520 CG LYS D 91 57.164 41.026 26.468 1.00 11.16 C

ATOM 9521 CD LYS D 91 57.624 40.363 25.181 1.00 14.59 C

ATOM 9522 CE LYS D 91 58.995 40.853 24.736 1.00 17.08 C

ATOM 9523 NZ LYS D 91 59.459 40.127 23.512 1.00 18.29 N

ATOM 9524 C LYS D 91 53.574 41.920 27.542 1.00 8.88 C

ATOM 9525 O LYS D 91 52.698 41.060 27.651 1.00 8.66 O

ATOM 9526 N THR D 92 53.316 43.178 27.189 1.00 8.61 N

ATOM 9527 CA THR D 92 51.944 43.622 26.928 1.00 8.32 C

ATOM 9528 CB THR D 92 51.520 44.773 27.865 1.00 8.40 C

ATOM 9529 OGl THR D 92 52.456 45.852 27.753 1.00 8.54 O

ATOM 9530 CG2 THR D 92 51.457 44.300 29.318 1.00 8.72 C

ATOM 9531 C THR D 92 51.716 44.036 25.473 1.00 7.86 C

ATOM 9532 O THR D 92 52.633 44.491 24.783 1.00 7.73 O

ATOM 9533 N LEU D 93 50.484 43.864 25.010 1.00 7.09 N

ATOM 9534 CA LEU D 93 50.107 44.326 23.682 1.00 6.89 C

ATOM 9535 CB LEU D 93 50.032 43.169 22.668 1.00 6.84 C

ATOM 9536 CG LEU D 93 51.331 42.421 22.341 1.00 7.35 C

ATOM 9537 CDl LEU D 93 51.526 41.228 23.275 1.00 8.79 C

ATOM 9538 CD2 LEU D 93 51.356 41.965 20.896 1.00 7.63 C

ATOM 9539 C LEU D 93 48.781 45.049 23.748 1.00 6.69 C

ATOM 9540 O LEU D 93 47.963 44.791 24.638 1.00 6.35 O

ATOM 9541 N LEU D 94 48.593 45.966 22.804 1.00 6.46 N

ATOM 9542 CA LEU D 94 47.339 46.668 22.627 1.00 6.51 C

ATOM 9543 CB LEU D 94 47.596 48.169 22.447 1.00 6.17 C

ATOM 9544 CG LEU D 94 46.407 49.116 22.254 1.00 5.93 C

ATOM 9545 CDl LEU D 94 45.437 49.090 23.437 1.00 4.90 C

ATOM 9546 CD2 LEU D 94 46.918 50.532 22.027 1.00 6.29 C

ATOM 9547 C LEU D 94 46.639 46.098 21.403 1.00 6.53 C

ATOM 9548 O LEU D 94 47.231 46.026 20.326 1.00 6.87 O

ATOM 9549 N ALA D 95 45.388 45.682 21.575 1.00 6.50 N

ATOM 9550 CA ALA D 95 44.596 45.163 20.464 1.00 6.54 C

ATOM 9551 CB ALA D 95 43.716 43.995 20.913 1.00 6.18 C

ATOM 9552 C ALA D 95 43.749 46.264 19.840 1.00 6.66 C

ATOM 9553 O ALA D 95 43.115 47.051 20.548 1.00 6.90 O

ATOM 9554 N ILE D 96 43.744 46.313 18.512 1.00 6.59 N

ATOM 9555 CA ILE D 96 42.888 47.238 17.775 1.00 6.56 C W2025-7029WO / AM102903-PCT

ATOM 9556 CB ILE D 96 43.714 48.170 16.835 1.00 6.57 C

ATOM 9557 CGl ILE D 96 42.815 49.261 16.218 1.00 6.97 C

ATOM 9558 CDl ILE D 96 43.561 50.373 15.531 1.00 6.30 C

ATOM 9559 CG2 ILE D 96 44.484 47.364 15.767 1.00 5.97 C

ATOM 9560 C ILE D 96 41.815 46.459 17.004 1.00 6.82 C

ATOM 9561 O ILE D 96 42.114 45.437 16.389 1.00 6.96 O

ATOM 9562 N GLY D 97 40.568 46.928 17.074 1.00 6.94 N

ATOM 9563 CA GLY D 97 39.478 46.355 16.288 1.00 7.16 C

ATOM 9564 C GLY D 97 38.361 45.755 17.125 1.00 7.57 C

ATOM 9565 O GLY D 97 37.789 46.423 17.999 1.00 7.38 O

ATOM 9566 N GLY D 98 38.060 44.488 16.855 1.00 7.77 N

ATOM 9567 CA GLY D 98 36.973 43.786 17.526 1.00 8.60 C

ATOM 9568 C GLY D 98 35.724 43.661 16.674 1.00 8.89 C

ATOM 9569 O GLY D 98 35.690 44.112 15.523 1.00 8.68 O

ATOM 9570 N TRP D 99 34.693 43.051 17.256 1.00 9.53 N

ATOM 9571 CA TRP D 99 33.448 42.739 16.553 1.00 10.13 C

ATOM 9572 CB TRP D 99 32.566 41.835 17.426 1.00 10.67 C

ATOM 9573 CG TRP D 99 31.346 41.235 16.753 1.00 10.70 C

ATOM 9574 CDl TRP D 99 30.046 41.603 16.945 1.00 11.94 C

ATOM 9575 NEl TRP D 99 29.210 40.813 16.187 1.00 12.05 N

ATOM 9576 CE2 TRP D 99 29.964 39.906 15.493 1.00 11.49 C

ATOM 9577 CD2 TRP D 99 31.317 40.138 15.826 1.00 11.02 C

ATOM 9578 CE3 TRP D 99 32.302 39.331 15.247 1.00 11.08 C

ATOM 9579 CZ3 TRP D 99 31.912 38.334 14.357 1.00 12.08 C

ATOM 9580 CH2 TRP D 99 30.554 38.132 14.039 1.00 11.27 C

ATOM 9581 CZ2 TRP D 99 29.569 38.903 14.595 1.00 11.80 C

ATOM 9582 C TRP D 99 32.700 44.003 16.151 1.00 10.53 C

ATOM 9583 O TRP D 99 32.411 44.198 14.973 1.00 10.52 O

ATOM 9584 N ASN D 100 32.404 44.861 17.127 1.00 11.09 N

ATOM 9585 CA ASN D 100 31.630 46.088 16.882 1.00 11.66 C

ATOM 9586 CB ASN D 100 31.196 46.733 18.200 1.00 12.11 C

ATOM 9587 CG ASN D 100 30.118 45.937 18.908 1.00 14.39 C

ATOM 9588 ODl ASN D 100 29.197 45.404 18.278 1.00 17.09 O

ATOM 9589 ND2 ASN D 100 30.221 45.853 20.228 1.00 16.54 N

ATOM 9590 C ASN D 100 32.323 47.119 15.986 1.00 11.25 C

ATOM 9591 O ASN D 100 31.659 47.821 15.220 1.00 11.49 O

ATOM 9592 N PHE D 101 33.651 47.187 16.081 1.00 10.67 N

ATOM 9593 CA PHE D 101 34.485 48.046 15.234 1.00 10.21 C

ATOM 9594 CB PHE D 101 35.962 47.817 15.572 1.00 10.09 C

ATOM 9595 CG PHE D 101 36.909 48.813 14.950 1.00 9.77 C

ATOM 9596 CDl PHE D 101 37.119 50.059 15.538 1.00 9.05 C

ATOM 9597 CEl PHE D 101 38.009 50.973 14.980 1.00 8.94 C

ATOM 9598 CZ PHE D 101 38.716 50.641 13.827 1.00 9.62 C

ATOM 9599 CE2 PHE D 101 38.521 49.397 13.233 1.00 9.42 C

ATOM 9600 CD2 PHE D 101 37.624 48.487 13.799 1.00 9.34 C

ATOM 9601 C PHE D 101 34.243 47.775 13.752 1.00 10.09 C

ATOM 9602 O PHE D 101 34.227 48.702 12.931 1.00 9.99 O

ATOM 9603 N GLY D 102 34.058 46.503 13.414 1.00 9.72 N

ATOM 9604 CA GLY D 102 33.781 46.107 12.039 1.00 9.66 C

ATOM 9605 C GLY D 102 35.001 46.260 11.154 1.00 9.27 C

ATOM 9606 O GLY D 102 36.139 46.253 11.637 1.00 9.07 O

ATOM 9607 N THR D 103 34.758 46.412 9.855 1.00 9.02 N

ATOM 9608 CA THR D 103 35.830 46.352 8.859 1.00 8.62 C

ATOM 9609 CB THR D 103 35.541 45.275 7.796 1.00 8.53 C

ATOM 9610 OGl THR D 103 34.317 45.588 7.110 1.00 8.52 O

ATOM 9611 CG2 THR D 103 35.429 43.893 8.446 1.00 8.64 C

ATOM 9612 C THR D 103 36.107 47.684 8.161 1.00 8.49 C

ATOM 9613 O THR D 103 37.232 47.931 7.731 1.00 8.35 O

ATOM 9614 N ALA D 104 35.082 48.531 8.051 1.00 8.28 N

ATOM 9615 CA ALA D 104 35.189 49.805 7.312 1.00 8.12 C

ATOM 9616 CB ALA D 104 33.929 50.671 7.512 1.00 8.18 C

ATOM 9617 C ALA D 104 36.473 50.619 7.584 1.00 7.75 C

ATOM 9618 O ALA D 104 37.166 50.991 6.632 1.00 7.29 O W2025-7029WO / AM102903-PCT

ATOM 9619 N PRO D 105 36.788 50.911 8.872 1.00 7.50 N

ATOM 9620 CA PRO D 105 37.995 51.709 9.123 1.00 7.12 C

ATOM 9621 CB PRO D 105 37.961 51.935 10.640 1.00 7.26 C

ATOM 9622 CG PRO D 105 36.535 51.699 11.035 1.00 7.03 C

ATOM 9623 CD PRO D 105 36.095 50.593 10.135 1.00 7.49 C

ATOM 9624 C PRO D 105 39.296 51.026 8.698 1.00 6.83 C

ATOM 9625 O PRO D 105 40.200 51.701 8.205 1.00 6.99 O

ATOM 9626 N PHE D 106 39.384 49.709 8.881 1.00 6.65 N

ATOM 9627 CA PHE D 106 40.534 48.932 8.410 1.00 6.32 C

ATOM 9628 CB PHE D 106 40.444 47.473 8.875 1.00 6.18 C

ATOM 9629 CG PHE D 106 40.819 47.247 10.319 1.00 6.25 C

ATOM 9630 CDl PHE D 106 42.088 47.577 10.794 1.00 5.81 C

ATOM 9631 CEl PHE D 106 42.437 47.352 12.134 1.00 6.80 C

ATOM 9632 CZ PHE D 106 41.517 46.765 13.007 1.00 6.32 C

ATOM 9633 CE2 PHE D 106 40.256 46.410 12.541 1.00 7.30 C

ATOM 9634 CD2 PHE D 106 39.909 46.658 11.196 1.00 6.28 C

ATOM 9635 C PHE D 106 40.682 48.977 6.878 1.00 5.90 C

ATOM 9636 O PHE D 106 41.777 49.216 6.367 1.00 5.70 O

ATOM 9637 N THR D 107 39.586 48.743 6.155 1.00 5.53 N

ATOM 9638 CA THR D 107 39.585 48.828 4.683 1.00 5.40 C

ATOM 9639 CB THR D 107 38.171 48.554 4.102 1.00 5.30 C

ATOM 9640 OGl THR D 107 37.744 47.241 4.488 1.00 4.60 O

ATOM 9641 CG2 THR D 107 38.161 48.662 2.577 1.00 4.95 C

ATOM 9642 C THR D 107 40.117 50.186 4.186 1.00 5.65 C

ATOM 9643 O THR D 107 41.038 50.242 3.352 1.00 5.75 O

ATOM 9644 N ALA D 108 39.548 51.267 4.715 1.00 5.76 N

ATOM 9645 CA ALA D 108 39.979 52.620 4.357 1.00 5.91 C

ATOM 9646 CB ALA D 108 39.107 53.653 5.043 1.00 5.97 C

ATOM 9647 C ALA D 108 41.463 52.836 4.694 1.00 6.03 C

ATOM 9648 O ALA D 108 42.219 53.370 3.877 1.00 5.99 O

ATOM 9649 N MET D 109 41.870 52.382 5.879 1.00 6.00 N

ATOM 9650 CA MET D 109 43.258 52.501 6.344 1.00 6.40 C

ATOM 9651 CB MET D 109 43.370 52.054 7.811 1.00 6.52 C

ATOM 9652 CG MET D 109 44.728 52.314 8.471 1.00 5.87 C

ATOM 9653 SD MET D 109 45.930 50.999 8.174 1.00 6.92 S

ATOM 9654 CE MET D 109 45.315 49.751 9.319 1.00 5.26 C

ATOM 9655 C MET D 109 44.285 51.764 5.465 1.00 6.62 C

ATOM 9656 O MET D 109 45.368 52.298 5.215 1.00 6.79 O

ATOM 9657 N VAL D 110 43.954 50.552 5.006 1.00 6.94 N

ATOM 9658 CA VAL D 110 44.889 49.753 4.181 1.00 7.06 C

ATOM 9659 CB VAL D 110 44.728 48.211 4.399 1.00 7.22 C

ATOM 9660 CGl VAL D 110 44.949 47.842 5.868 1.00 7.05 C

ATOM 9661 CG2 VAL D 110 43.374 47.702 3.895 1.00 6.33 C

ATOM 9662 C VAL D 110 44.851 50.089 2.677 1.00 7.51 C

ATOM 9663 O VAL D 110 45.772 49.734 1.925 1.00 7.47 O

ATOM 9664 N SER D 111 43.796 50.784 2.258 1.00 7.95 N

ATOM 9665 CA SER D 111 43.557 51.126 0.852 1.00 8.45 C

ATOM 9666 CB SER D 111 42.311 52.011 0.717 1.00 8.49 C

ATOM 9667 OG SER D 111 42.502 53.266 1.338 1.00 8.20 O

ATOM 9668 C SER D 111 44.736 51.777 0.118 1.00 8.89 C

ATOM 9669 O SER D 111 44.981 51.466 -1.052 1.00 8.64 O

ATOM 9670 N THR D 112 45.437 52.688 0.799 1.00 9.13 N

ATOM 9671 CA THR D 112 46.535 53.450 0.196 1.00 9.53 C

ATOM 9672 CB THR D 112 46.153 54.950 -0.026 1.00 9.63 C

ATOM 9673 OGl THR D 112 46.039 55.624 1.233 1.00 9.84 O

ATOM 9674 CG2 THR D 112 44.847 55.093 -0.793 1.00 9.68 C

ATOM 9675 C THR D 112 47.807 53.390 1.047 1.00 9.83 C

ATOM 9676 O THR D 112 47.725 53.226 2.265 1.00 9.70 O

ATOM 9677 N PRO D 113 48.991 53.527 0.413 1.00 10.15 N

ATOM 9678 CA PRO D 113 50.236 53.609 1.183 1.00 10.51 C

ATOM 9679 CB PRO D 113 51.311 53.811 0.105 1.00 10.60 C

ATOM 9680 CG PRO D 113 50.701 53.301 -1.152 1.00 10.59 C

ATOM 9681 CD PRO D 113 49.239 53.591 -1.041 1.00 10.18 C W2025-7029WO / AM102903-PCT

ATOM 9682 C PRO D 113 50.272 54.773 2.185 1.00 10.85 C

ATOM 9683 O PRO D 113 50.853 54.625 3.265 1.00 10.79 O

ATOM 9684 N GLU D 114 49.673 55.913 1.819 1.00 10.88 N

ATOM 9685 CA GLU D 114 49.606 57.087 2.699 1.00 11.41 C

ATOM 9686 CB GLU D 114 48.991 58.292 1.971 1.00 11.31 C

ATOM 9687 CG GLU D 114 49.126 59.617 2.739 1.00 13.15 C

ATOM 9688 CD GLU D 114 48.166 60.700 2.257 1.00 13.40 C

ATOM 9689 OEl GLU D 114 48.043 60.904 1.029 1.00 16.20 O

ATOM 9690 OE2 GLU D 114 47.541 61.360 3.115 1.00 16.39 O

ATOM 9691 C GLU D 114 48.826 56.805 3.985 1.00 10.65 C

ATOM 9692 O GLU D 114 49.271 57.166 5.076 1.00 10.25 O

ATOM 9693 N ASN D 115 47.662 56.167 3.855 1.00 10.16 N

ATOM 9694 CA ASN D 115 46.844 55.853 5.024 1.00 9.67 C

ATOM 9695 CB ASN D 115 45.456 55.352 4.610 1.00 9.72 C

ATOM 9696 CG ASN D 115 44.577 56.449 4.029 1.00 9.59 C

ATOM 9697 ODl ASN D 115 45.004 57.595 3.870 1.00 8.98 O

ATOM 9698 ND2 ASN D 115 43.334 56.095 3.706 1.00 9.30 N

ATOM 9699 C ASN D 115 47.530 54.856 5.960 1.00 9.50 C

ATOM 9700 O ASN D 115 47.474 55.010 7.185 1.00 9.43 O

ATOM 9701 N ARG D 116 48.188 53.852 5.373 1.00 8.90 N

ATOM 9702 CA ARG D 116 48.940 52.840 6.130 1.00 8.56 C

ATOM 9703 CB ARG D 116 49.462 51.729 5.211 1.00 8.36 C

ATOM 9704 CG ARG D 116 48.366 50.927 4.513 1.00 7.59 C

ATOM 9705 CD ARG D 116 48.880 49.624 3.936 1.00 6.74 C

ATOM 9706 NE ARG D 116 49.925 49.813 2.925 1.00 6.75 N

ATOM 9707 CZ ARG D 116 49.716 49.900 1.611 1.00 6.18 C

ATOM 9708 NHl ARG D 116 48.488 49.833 1.110 1.00 5.09 N

ATOM 9709 NH2 ARG D 116 50.750 50.054 0.792 1.00 5.40 N

ATOM 9710 C ARG D 116 50.099 53.444 6.912 1.00 8.43 C

ATOM 9711 O ARG D 116 50.297 53.103 8.076 1.00 8.32 O

ATOM 9712 N GLN D 117 50.855 54.338 6.273 1.00 8.25 N

ATOM 9713 CA GLN D 117 51.978 55.021 6.934 1.00 8.36 C

ATOM 9714 CB GLN D 117 52.863 55.743 5.912 1.00 8.45 C

ATOM 9715 CG GLN D 117 53.718 54.818 5.055 1.00 9.53 C

ATOM 9716 CD GLN D 117 54.702 53.975 5.861 1.00 11.30 C

ATOM 9717 OEl GLN D 117 55.252 54.424 6.869 1.00 12.46 O

ATOM 9718 NE2 GLN D 117 54.930 52.743 5.409 1.00 12.48 N

ATOM 9719 C GLN D 117 51.520 55.989 8.030 1.00 8.03 C

ATOM 9720 O GLN D 117 52.171 56.115 9.068 1.00 7.96 O

ATOM 9721 N THR D 118 50.397 56.661 7.790 1.00 8.11 N

ATOM 9722 CA THR D 118 49.744 57.501 8.796 1.00 8.08 C

ATOM 9723 CB THR D 118 48.457 58.155 8.223 1.00 8.24 C

ATOM 9724 OGl THR D 118 48.812 59.056 7.162 1.00 8.74 O

ATOM 9725 CG2 THR D 118 47.680 58.923 9.303 1.00 8.64 C

ATOM 9726 C THR D 118 49.427 56.661 10.035 1.00 7.75 C

ATOM 9727 O THR D 118 49.749 57.050 11.163 1.00 7.47 O

ATOM 9728 N PHE D 119 48.822 55.496 9.807 1.00 7.39 N

ATOM 9729 CA PHE D 119 48.505 54.549 10.875 1.00 7.06 C

ATOM 9730 CB PHE D 119 47.663 53.387 10.329 1.00 6.95 C

ATOM 9731 CG PHE D 119 47.255 52.388 11.380 1.00 6.95 C

ATOM 9732 CDl PHE D 119 46.285 52.708 12.331 1.00 6.48 C

ATOM 9733 CEl PHE D 119 45.912 51.781 13.303 1.00 6.10 C

ATOM 9734 CZ PHE D 119 46.505 50.523 13.331 1.00 6.07 C

ATOM 9735 CE2 PHE D 119 47.478 50.193 12.390 1.00 6.60 C

ATOM 9736 CD2 PHE D 119 47.847 51.126 11.422 1.00 6.47 C

ATOM 9737 C PHE D 119 49.747 54.013 11.597 1.00 7.06 C

ATOM 9738 O PHE D 119 49.790 53.990 12.830 1.00 6.94 O

ATOM 9739 N ILE D 120 50.751 53.589 10.832 1.00 6.68 N

ATOM 9740 CA ILE D 120 51.985 53.044 11.414 1.00 6.48 C

ATOM 9741 CB ILE D 120 52.934 52.484 10.316 1.00 6.60 C

ATOM 9742 CGl ILE D 120 52.400 51.146 9.791 1.00 6.82 C

ATOM 9743 CDl ILE D 120 52.827 50.805 8.362 1.00 7.71 C

ATOM 9744 CG2 ILE D 120 54.356 52.291 10.850 1.00 6.94 C W2025-7029WO / AM102903-PCT

ATOM 9745 C ILE D 120 52.685 54 076 12.321 .00 6.31 C

ATOM 9746 O ILE D 120 53.094 53 753 13.442 .00 5.77 O

ATOM 9747 N THR D 121 52.802 55 310 11.827 .00 6.24 N

ATOM 9748 CA THR D 121 53.341 56 433 12.597 .00 6.29 C

ATOM 9749 CB THR D 121 53.305 57 749 11.774 .00 6.28 C

ATOM 9750 OGl THR D 121 54.121 57 598 10.608 .00 7.62 O

ATOM 9751 CG2 THR D 121 53.832 58 947 12.588 .00 6.60 C

ATOM 9752 C THR D 121 52.596 56 610 13.925 .00 6.01 C

ATOM 9753 O THR D 121 53.221 56 694 14.982 .00 6.22 O

ATOM 9754 N SER D 122 51.266 56 657 13.864 .00 5.78 N

ATOM 9755 CA SER D 122 50.445 56 799 15.062 .00 5.75 C

ATOM 9756 CB SER D 122 48.960 56 911 14.705 .00 5.90 C

ATOM 9757 OG SER D 122 48.402 55 14.309 .00 6.80 O

ATOM 9758 C SER D 122 50.672 55. 655 16.046 1.00 75 C

ATOM 9759 O SER D 122 50.726 55.879 17.253 1.00 76 O

ATOM 9760 N VAL D 123 50.808 54.439 15.520 1.00 53 N

ATOM 9761 CA VAL D 123 50.990 53.245 16.348 1.00 71 C

ATOM 9762 CB VAL D 123 50.839 51.939 15.518 1.00 78 C

ATOM 9763 CGl VAL D 123 51.379 50.730 16.281 1.00 50 C

ATOM 9764 CG2 VAL D 123 49.377 51.715 15.149 1.00 02 C

ATOM 9765 C VAL D 123 52.305 53.273 17.139 1.00 78 C

ATOM 9766 O VAL D 123 52.300 53.048 18.345 1.00 5.77 O

ATOM 9767 N ILE D 124 53.420 53.566 16.468 1.00 6.13 N

ATOM 9768 CA ILE D 124 54.724 53.632 17.144 1.00 6.81 C

ATOM 9769 CB ILE D 124 55.864 54.020 16.160 1.00 6.83 C

ATOM 9770 CGl ILE D 124 56.090 52.904 15.128 1.00 6.75 C

ATOM 9771 CDl ILE D 124 57.144 53.212 14.062 1.00 6.92 C

ATOM 9772 CG2 ILE D 124 57.151 54.353 16.927 1.00 7.13 C

ATOM 9773 C ILE D 124 54.686 54.628 18.317 1.00 7.07 C

ATOM 9774 O ILE D 124 55.125 54.320 19.430 1.00 7.14 O

ATOM 9775 N LYS D 125 54.154 55.817 18.052 1.00 7.26 N

ATOM 9776 CA LYS D 125 54.031 56.861 19.067 1.00 8.02 C

ATOM 9777 CB LYS D 125 53.472 58.153 18.457 1.00 8.02 C

ATOM 9778 CG LYS D 125 54.453 58.791 17.502 1.00 10.45 C

ATOM 9779 CD LYS D 125 54.053 166 17.021 1.00 14.21 C

ATOM 9780 CE LYS D 125 55.175 60.722 16.160 1.00 15.87 C

ATOM 9781 NZ LYS D 125 54.633 61.449 14.988 1.00 19.27 N

ATOM 9782 C LYS D 125 53.171 56.400 20.236 1.00 7.48 C

ATOM 9783 O LYS D 125 53.569 56.537 21.385 1.00 7.23 O

ATOM 9784 N PHE D 126 52.014 55.821 19.921 1.00 7.71 N

ATOM 9785 CA PHE D 126 51.049 55.364 20.924 1.00 7.72 C

ATOM 9786 CB PHE D 126 49.806 54.836 20.209 1.00 7.80 C

ATOM 9787 CG PHE D 126 48.514 55.046 20.957 1.00 7.89 C

ATOM 9788 CDl PHE D 126 47.949 54.013 21.701 1.00 7.55 C

ATOM 9789 CEl PHE D 126 46.737 54.191 22.374 1.00 7.45 C

ATOM 9790 CZ PHE D 126 46.071 55.416 22.295 1.00 7.39 C

ATOM 9791 CE2 PHE D 126 46.616 56.450 21.544 1.00 8.26 C

ATOM 9792 CD2 PHE D 126 47.833 56.263 20.874 1.00 7.99 C

ATOM 9793 C PHE D 126 51.634 54.283 21.849 1.00 7.69 C

ATOM 9794 O PHE D 126 51.514 54.377 23.068 1.00 7.78 O

ATOM 9795 N LEU D 127 52.269 53.265 21.270 1.00 7.68 N

ATOM 9796 CA LEU D 127 52.802 52.141 22.060 1.00 7.54 C

ATOM 9797 CB LEU D 127 53.229 50.964 21.162 1.00 7.43 C

ATOM 9798 CG LEU D 127 52.150 50.327 20.271 1.00 7.77 C

ATOM 9799 CDl LEU D 127 52.727 49.197 19.423 1.00 6.60 C

ATOM 9800 CD2 LEU D 127 50.939 49.843 21.076 1.00 6.94 C

ATOM 9801 C LEU D 127 53.945 52.562 22.984 1.00 7.40 C

ATOM 9802 O LEU D 127 53.955 52.213 24.167 1.00 7.06 O

ATOM 9803 N ARG D 128 54.889 53.329 22.446 1.00 7.16 N

ATOM 9804 CA ARG D 128 56.045 53.778 23.223 1.00 7.44 C

ATOM 9805 CB ARG D 128 57.095 54.455 22.324 1.00 7.43 C

ATOM 9806 CG ARG D 128 57.812 53.504 21.362 1.00 7.64 C

ATOM 9807 CD ARG D 128 58.393 52.277 22.075 1.00 6.72 C W2025-7029WO / AM102903-PCT

ATOM 9808 NE ARG D 128 59.334 51.539 21.234 1.00 6.89 N

ATOM 9809 CZ ARG D 128 59.933 50.397 21.573 1.00 7.52 C

ATOM 9810 NHl ARG D 128 59.691 49.816 22.747 1.00 6.83 N

ATOM 9811 NH2 ARG D 128 60.783 49.825 20.725 1.00 8.01 N

ATOM 9812 C ARG D 128 55.682 54.679 24.400 1.00 7.53 C

ATOM 9813 O ARG D 128 56.233 54.521 25.489 1.00 7.52 O

ATOM 9814 N GLN D 129 54.751 55.609 24.187 1.00 7.54 N

ATOM 9815 CA GLN D 129 54.351 56.543 25.243 1.00 8.09 C

ATOM 9816 CB GLN D 129 53.522 57.719 24.682 1.00 7.78 C

ATOM 9817 CG GLN D 129 52.120 57.368 24.197 1.00 8.59 C

ATOM 9818 CD GLN D 129 51.449 58.495 23.423 1.00 9.06 C

ATOM 9819 OEl GLN D 129 52.102 59.441 22.989 1.00 11.12 O

ATOM 9820 NE2 GLN D 129 50.135 58.388 23.237 1.00 10.21 N

ATOM 9821 C GLN D 129 53.645 55.861 26.428 1.00 7.94 C

ATOM 9822 O GLN D 129 53.777 56.312 27.572 1.00 7.70 O

ATOM 9823 N TYR D 130 52.920 54.772 26.150 1.00 7.91 N

ATOM 9824 CA TYR D 130 52.215 54.026 27.196 1.00 7.96 C

ATOM 9825 CB TYR D 130 50.791 53.650 26.747 1.00 7.83 C

ATOM 9826 CG TYR D 130 49.950 54.844 26.356 1.00 7.35 C

ATOM 9827 CDl TYR D 130 49.814 55.934 27.214 1.00 7.05 C

ATOM 9828 CEl TYR D 130 49.047 57.043 26.854 1.00 6.91 C

ATOM 9829 CZ TYR D 130 48.403 57.060 25.630 1.00 7.24 C

ATOM 9830 OH TYR D 130 47.647 58.152 25.264 1.00 7.44 O

ATOM 9831 CE2 TYR D 130 48.520 55.988 24.762 1.00 6.76 C

ATOM 9832 CD2 TYR D 130 49.292 54.886 25.127 1.00 7.54 C

ATOM 9833 C TYR D 130 52.972 52.794 27.695 1.00 8.43 C

ATOM 9834 O TYR D 130 52.519 52.132 28.626 1.00 8.37 O

ATOM 9835 N GLU D 131 54.125 52.504 27.087 1.00 8.70 N

ATOM 9836 CA GLU D 131 54.944 51.333 27.440 1.00 9.58 C

ATOM 9837 CB GLU D 131 55.421 51.390 28.909 1.00 9.40 C

ATOM 9838 CG GLU D 131 56.227 52.647 29.285 1.00 11.19 C

ATOM 9839 CD GLU D 131 56.363 52.867 30.803 1.00 12.44 C

ATOM 9840 OEl GLU D 131 56.460 54.044 31.230 1.00 16.35 O

ATOM 9841 OE2 GLU D 131 56.367 51.877 31.575 1.00 16.62 O

ATOM 9842 C GLU D 131 54.246 49.990 27.111 1.00 8.93 C

ATOM 9843 O GLU D 131 54.352 49.022 27.869 1.00 8.89 O

ATOM 9844 N PHE D 132 53.535 49.951 25.980 1.00 8.42 N

ATOM 9845 CA PHE D 132 53.064 48.695 25.382 1.00 7.91 C

ATOM 9846 CB PHE D 132 51.875 48.938 24.443 1.00 8.01 C

ATOM 9847 CG PHE D 132 50.545 49.050 25.140 1.00 7.77 C

ATOM 9848 CDl PHE D 132 49.934 47.926 25.694 1.00 8.17 C

ATOM 9849 CEl PHE D 132 48.695 48.021 26.334 1.00 6.91 C

ATOM 9850 CZ PHE D 132 48.051 49.244 26.413 1.00 8.30 C

ATOM 9851 CE2 PHE D 132 48.641 50.376 25.850 1.00 8.87 C

ATOM 9852 CD2 PHE D 132 49.884 50.270 25.210 1.00 8.32 C

ATOM 9853 C PHE D 132 54.206 48.070 24.581 1.00 7.62 C

ATOM 9854 O PHE D 132 54.997 48.785 23.955 1.00 7.51 O

ATOM 9855 N ASP D 133 54.282 46.741 24.588 1.00 7.03 N

ATOM 9856 CA ASP D 133 55.356 46.016 23.895 1.00 6.71 C

ATOM 9857 CB ASP D 133 55.757 44.771 24.689 1.00 6.77 C

ATOM 9858 CG ASP D 133 56.308 45.113 26.040 1.00 7.06 C

ATOM 9859 ODl ASP D 133 57.418 45.684 26.088 1.00 7.23 O

ATOM 9860 OD2 ASP D 133 55.630 44.825 27.046 1.00 8.07 O

ATOM 9861 C ASP D 133 55.012 45.630 22.456 1.00 6.37 C

ATOM 9862 O ASP D 133 55.851 45.082 21.739 1.00 6.40 O

ATOM 9863 N GLY D 134 53.783 45.900 22.037 1.00 6.10 N

ATOM 9864 CA GLY D 134 53.389 45.621 20.662 1.00 5.74 C

ATOM 9865 C GLY D 134 51.931 45.871 20.331 1.00 5.64 C

ATOM 9866 O GLY D 134 51.139 46.274 21.189 1.00 5.30 O

ATOM 9867 N LEU D 135 51.595 45.639 19.064 1.00 5.56 N

ATOM 9868 CA LEU D 135 50.223 45.754 18.577 1.00 5.38 C

ATOM 9869 CB LEU D 135 50.146 46.732 17.396 1.00 5.15 C

ATOM 9870 CG LEU D 135 48.742 47.041 16.863 1.00 5.14 C W2025-7029WO / AM102903-PCT

ATOM 9871 CDl LEU D 135 48.046 48.086 17.730 1.00 4.06 C

ATOM 9872 CD2 LEU D 135 48.812 47.495 15.408 1.00 4.02 C

ATOM 9873 C LEU D 135 49.675 44.397 18.148 1.00 5.21 C

ATOM 9874 O LEU D 135 50.358 43.633 17.462 1.00 5.11 O

ATOM 9875 N ASP D 136 48.438 44.115 18.562 1.00 5.08 N

ATOM 9876 CA ASP D 136 47.698 42.931 18.136 1.00 5.22 C

ATOM 9877 CB ASP D 136 47.140 42.177 19.365 1.00 5.04 C

ATOM 9878 CG ASP D 136 46.422 40.857 19.003 1.00 4.80 C

ATOM 9879 ODl ASP D 136 46.985 40.018 18.277 1.00 2.54 O

ATOM 9880 OD2 ASP D 136 45.283 40.650 19.479 1.00 5.15 O

ATOM 9881 C ASP D 136 46.563 43.397 17.232 1.00 5.35 C

ATOM 9882 O ASP D 136 45.703 44.168 17.659 1.00 5.35 O

ATOM 9883 N PHE D 137 46.571 42.943 15.983 1.00 5.54 N

ATOM 9884 CA PHE D 137 45.482 43.242 15.059 1.00 5.71 C

ATOM 9885 CB PHE D 137 45.940 43.067 13.601 1.00 5.57 C

ATOM 9886 CG PHE D 137 46.784 44.205 13.074 1.00 5.26 C

ATOM 9887 CDl PHE D 137 48.151 44.034 12.866 1.00 5.07 C

ATOM 9888 CEl PHE D 137 48.946 45.082 12.365 1.00 5.08 C

ATOM 9889 CZ PHE D 137 48.360 46.317 12.067 1.00 4.80 C

ATOM 9890 CE2 PHE D 137 46.991 46.501 12.270 1.00 4.35 C

ATOM 9891 CD2 PHE D 137 46.208 45.440 12.770 1.00 4.66 C

ATOM 9892 C PHE D 137 44.294 42.320 15.348 1.00 5.94 C

ATOM 9893 O PHE D 137 44.437 41.103 15.300 1.00 5.67 O

ATOM 9894 N ASP D 138 43.133 42.902 15.652 1.00 6.50 N

ATOM 9895 CA ASP D 138 41.893 42.131 15.790 1.00 7.23 C

ATOM 9896 CB ASP D 138 41.330 42.215 17.214 1.00 7.61 C

ATOM 9897 CG ASP D 138 42.215 41.529 18.238 1.00 10.33 C

ATOM 9898 ODl ASP D 138 41.690 40.727 19.049 1.00 12.97 O

ATOM 9899 OD2 ASP D 138 43.439 41.791 18.239 1.00 13.10 O

ATOM 9900 C ASP D 138 40.858 42.591 14.764 1.00 7.15 C

ATOM 9901 O ASP D 138 39.747 43.009 15.111 1.00 6.71 O

ATOM 9902 N TRP D 139 41.258 42.518 13.497 1.00 7.02 N

ATOM 9903 CA TRP D 139 40.404 42.817 12.354 1.00 6.98 C

ATOM 9904 CB TRP D 139 41.301 43.079 11.134 1.00 6.60 C

ATOM 9905 CG TRP D 139 40.622 43.495 9.844 1.00 6.00 C

ATOM 9906 CDl TRP D 139 39.289 43.410 9.533 1.00 6.03 C

ATOM 9907 NEl TRP D 139 39.067 43.871 8.255 1.00 5.29 N

ATOM 9908 CE2 TRP D 139 40.264 44.254 7.707 1.00 4.89 C

ATOM 9909 CD2 TRP D 139 41.268 44.027 8.678 1.00 5.68 C

ATOM 9910 CE3 TRP D 139 42.600 44.343 8.361 1.00 5.86 C

ATOM 9911 CZ3 TRP D 139 42.881 44.874 7.101 1.00 5.87 C

ATOM 9912 CH2 TRP D 139 41.858 45.082 6.161 1.00 5.90 C

ATOM 9913 CZ2 TRP D 139 40.549 44.781 6.446 1.00 5.54 C

ATOM 9914 C TRP D 139 39.504 41.605 12.112 1.00 7.12 C

ATOM 9915 O TRP D 139 39.985 40.527 11.781 1.00 7.54 O

ATOM 9916 N GLU D 140 38.199 41.776 12.301 1.00 7.33 N

ATOM 9917 CA GLU D 140 37.254 40.686 12.082 1.00 7.60 C

ATOM 9918 CB GLU D 140 36.492 40.356 13.378 1.00 7.49 C

ATOM 9919 CG GLU D 140 37.392 40.168 14.618 1.00 8.60 C

ATOM 9920 CD GLU D 140 36.600 39.917 15.895 1.00 9.21 C

ATOM 9921 OEl GLU D 140 35.460 39.414 15.802 1.00 13.89 O

ATOM 9922 OE2 GLU D 140 37.108 40.223 16.996 1.00 10.31 O

ATOM 9923 C GLU D 140 36.291 40.995 10.915 1.00 7.01 C

ATOM 9924 O GLU D 140 35.246 41.621 11.118 1.00 6.78 O

ATOM 9925 N TYR D 141 36.633 40.594 9.689 1.00 6.97 N

ATOM 9926 CA TYR D 141 37.908 39.973 9.303 1.00 6.86 C

ATOM 9927 CB TYR D 141 37.744 38.450 9.132 1.00 7.13 C

ATOM 9928 CG TYR D 141 37.251 37.747 10.376 1.00 7.49 C

ATOM 9929 CDl TYR D 141 35.889 37.543 10.588 1.00 7.44 C

ATOM 9930 CEl TYR D 141 35.426 36.920 11.736 1.00 8.30 C

ATOM 9931 CZ TYR D 141 36.330 36.490 12.688 1.00 7.97 C

ATOM 9932 OH TYR D 141 35.871 35.864 13.822 1.00 9.51 O

ATOM 9933 CE2 TYR D 141 37.688 36.682 12.506 1.00 8.05 C W2025-7029WO / AM102903-PCT

ATOM 9934 CD2 TYR D 141 38.143 37.311 11.355 1.00 7.06 C

ATOM 9935 C TYR D 141 38.299 40.591 7.967 1.00 6.87 C

ATOM 9936 O TYR D 141 37.430 41.143 7.280 1.00 6.56 O

ATOM 9937 N PRO D 142 39.596 40.516 7.582 1.00 6.69 N

ATOM 9938 CA PRO D 142 39.879 40.900 6.200 1.00 6.83 C

ATOM 9939 CB PRO D 142 41.385 40.635 6.048 1.00 6.77 C

ATOM 9940 CG PRO D 142 41.929 40.595 7.433 1.00 7.31 C

ATOM 9941 CD PRO D 142 40.812 40.109 8.314 1.00 6.63 C

ATOM 9942 C PRO D 142 39.090 39.980 5.265 1.00 6.90 C

ATOM 9943 O PRO D 142 38.968 38.786 5.538 1.00 7.06 O

ATOM 9944 N GLY D 143 38.531 40.541 4.199 1.00 7.10 N

ATOM 9945 CA GLY D 143 37.819 39.750 3.198 1.00 7.40 C

ATOM 9946 C GLY D 143 36.433 39.253 3.585 1.00 7.88 C

ATOM 9947 O GLY D 143 35.805 38.529 2.814 1.00 7.78 O

ATOM 9948 N SER D 144 35.953 39.625 4.771 1.00 8.21 N

ATOM 9949 CA SER D 144 34.589 39.269 5.192 1.00 8.77 C

ATOM 9950 CB SER D 144 34.527 37.865 5.808 1.00 8.72 C

ATOM 9951 OG SER D 144 35.378 37.758 6.931 1.00 9.62 O

ATOM 9952 C SER D 144 33.985 40.304 6.132 1.00 8.82 C

ATOM 9953 O SER D 144 34.640 41.285 6.494 1.00 8.80 O

ATOM 9954 N ARG D 145 32.728 40.089 6.512 1.00 8.94 N

ATOM 9955 CA ARG D 145 31.976 41.066 7.314 1.00 9.03 C

ATOM 9956 CB ARG D 145 32.432 41.044 8.786 1.00 9.03 C

ATOM 9957 CG ARG D 145 32.155 39.712 9.489 1.00 9.41 C

ATOM 9958 CD ARG D 145 32.428 39.748 10.988 1.00 9.80 C

ATOM 9959 NE ARG D 145 31.421 40.509 11.727 1.00 12.06 N

ATOM 9960 CZ ARG D 145 31.647 41.657 12.363 1.00 12.73 C

ATOM 9961 NHl ARG D 145 30.652 42.259 13.011 1.00 13.62 N

ATOM 9962 NH2 ARG D 145 32.859 42.204 12.373 1.00 11.96 N

ATOM 9963 C ARG D 145 32.046 42.478 6.700 1.00 8.72 C

ATOM 9964 O ARG D 145 32.226 43.472 7.404 1.00 8.95 O

ATOM 9965 N GLY D 146 31.914 42.553 5.378 1.00 8.46 N

ATOM 9966 CA GLY D 146 31.909 43.838 4.669 1.00 8.14 C

ATOM 9967 C GLY D 146 33.209 44.211 3.973 1.00 7.74 C

ATOM 9968 O GLY D 146 33.203 44.987 3.015 1.00 7.62 O

ATOM 9969 N SER D 147 34.322 43.666 4.459 1.00 7.28 N

ATOM 9970 CA SER D 147 35.638 43.912 3.881 1.00 7.12 C

ATOM 9971 CB SER D 147 36.733 43.380 4.815 1.00 6.91 C

ATOM 9972 OG SER D 147 37.990 43.337 4.169 1.00 7.41 O

ATOM 9973 C SER D 147 35.761 43.275 2.487 1.00 6.92 C

ATOM 9974 O SER D 147 35.472 42.092 2.321 1.00 6.97 O

ATOM 9975 N PRO D 148 36.186 44.068 1.481 1.00 6.71 N

ATOM 9976 CA PRO D 148 36.330 43.574 0.107 1.00 6.43 C

ATOM 9977 CB PRO D 148 36.479 44.867 -0.706 1.00 6.62 C

ATOM 9978 CG PRO D 148 37.126 45.830 0.247 1.00 6.40 C

ATOM 9979 CD PRO D 148 36.548 45.496 1.597 1.00 6.15 C

ATOM 9980 C PRO D 148 37.551 42.649 -0.076 1.00 6.38 C

ATOM 9981 O PRO D 148 38.474 42.677 0.747 1.00 6.26 O

ATOM 9982 N PRO D 149 37.550 41.823 -1.144 1.00 6.39 N

ATOM 9983 CA PRO D 149 38.598 40.821 -1.407 1.00 6.43 C

ATOM 9984 CB PRO D 149 38.195 40.237 -2.767 1.00 6.48 C

ATOM 9985 CG PRO D 149 36.740 40.468 -2.857 1.00 6.70 C

ATOM 9986 CD PRO D 149 36.499 41.783 -2.180 1.00 6.39 C

ATOM 9987 C PRO D 149 40.049 41.332 -1.465 1.00 6.46 C

ATOM 9988 O PRO D 149 40.970 40.574 -1.136 1.00 6.25 O

ATOM 9989 N GLN D 150 40.260 42.584 -1.881 1.00 6.62 N

ATOM 9990 CA GLN D 150 41.628 43.140 -1.944 1.00 6.73 C

ATOM 9991 CB GLN D 150 41.673 44.497 -2.676 1.00 6.85 C

ATOM 9992 CG GLN D 150 40.886 45.643 -2.019 1.00 6.74 C

ATOM 9993 CD GLN D 150 39.460 45.758 -2.537 1.00 6.76 C

ATOM 9994 OEl GLN D 150 38.874 44.779 -3.005 1.00 6.64 O

ATOM 9995 NE2 GLN D 150 38.893 46.962 -2.453 1.00 6.99 N

ATOM 9996 C GLN D 150 42.300 43.247 -0.565 1.00 6.65 C W2025-7029WO / AM102903-PCT

ATOM 9997 O GLN D 150 43.535 43.314 -0.466 1.00 6.45 O

ATOM 9998 N ASP D 151 41.486 43.253 0.490 1.00 6.70 N

ATOM 9999 CA ASP D 151 41.985 43.391 1.862 1.00 6.98 C

ATOM 10000 CB ASP D 151 40.839 43.686 2.839 1.00 6.84 C

ATOM 10001 CG ASP D 151 40.322 45.118 2.736 1.00 7.48 C

ATOM 10002 ODl ASP D 151 40.830 45.906 1.903 1.00 7.43 O

ATOM 10003 OD2 ASP D 151 39.399 45.457 3.505 1.00 7.93 O

ATOM 10004 C ASP D 151 42.804 42.197 2.361 1.00 6.94 C

ATOM 10005 O ASP D 151 43.596 42.338 3.298 1.00 6.88 O

ATOM 10006 N LYS D 152 42.595 41.030 1.749 1.00 6.83 N

ATOM 10007 CA LYS D 152 43.374 39.830 2.060 1.00 6.89 C

ATOM 10008 CB LYS D 152 42.848 38.617 1.272 1.00 6.87 C

ATOM 10009 CG LYS D 152 43.711 37.347 1.358 1.00 7.04 C

ATOM 10010 CD LYS D 152 43.078 36.168 0.603 1.00 6.69 C

ATOM 10011 CE LYS D 152 44.107 35.062 0.377 1.00 6.68 C

ATOM 10012 NZ LYS D 152 43.524 33.780 -0.113 1.00 6.43 N

ATOM 10013 C LYS D 152 44.865 40.085 1.795 1.00 6.83 C

ATOM 10014 O LYS D 152 45.689 39.926 2.695 1.00 6.97 O

ATOM 10015 N HIS D 153 45.201 40.498 0.575 1.00 6.70 N

ATOM 10016 CA HIS D 153 46.582 40.868 0.256 1.00 6.77 C

ATOM 10017 CB HIS D 153 46.807 41.014 -1.256 1.00 6.52 C

ATOM 10018 CG HIS D 153 48.200 41.444 -1.616 1.00 7.40 C

ATOM 10019 NDl HIS D 153 49.299 40.631 -1.441 1.00 8.41 N

ATOM 10020 CEl HIS D 153 50.389 41.272 -1.827 1.00 8.52 C

ATOM 10021 NE2 HIS D 153 50.036 42.473 -2.249 1.00 8.83 N

ATOM 10022 CD2 HIS D 153 48.672 42.609 -2.122 1.00 8.60 C

ATOM 10023 C HIS D 153 47.037 42.136 0.983 1.00 6.62 C

ATOM 10024 O HIS D 153 48.169 42.198 1.470 1.00 6.53 O

ATOM 10025 N LEU D 154 46.162 43.138 1.059 1.00 6.72 N

ATOM 10026 CA LEU D 154 46.538 44.421 1.675 1.00 6.96 C

ATOM 10027 CB LEU D 154 45.487 45.513 1.424 1.00 6.75 C

ATOM 10028 CG LEU D 154 45.436 46.165 0.033 1.00 7.15 C

ATOM 10029 CDl LEU D 154 44.235 47.090 -0.076 1.00 6.89 C

ATOM 10030 CD2 LEU D 154 46.725 46.914 -0.318 1.00 8.66 C

ATOM 10031 C LEU D 154 46.870 44.303 3.165 1.00 6.90 C

ATOM 10032 O LEU D 154 47.637 45.111 3.695 1.00 6.88 O

ATOM 10033 N PHE D 155 46.305 43.289 3.825 1.00 7.18 N

ATOM 10034 CA PHE D 155 46.636 42.989 5.227 1.00 6.88 C

ATOM 10035 CB PHE D 155 45.665 41.958 5.809 1.00 7.27 C

ATOM 10036 CG PHE D 155 45.827 41.720 7.291 1.00 7.17 C

ATOM 10037 CDl PHE D 155 45.891 42.789 8.185 1.00 8.36 C

ATOM 10038 CEl PHE D 155 46.027 42.575 9.554 1.00 7.87 C

ATOM 10039 CZ PHE D 155 46.101 41.273 10.050 1.00 8.53 C

ATOM 10040 CE2 PHE D 155 46.030 40.192 9.169 1.00 8.22 C

ATOM 10041 CD2 PHE D 155 45.895 40.423 7.794 1.00 8.05 C

ATOM 10042 C PHE D 155 48.083 42.512 5.358 1.00 6.92 C

ATOM 10043 O PHE D 155 48.796 42.928 6.274 1.00 6.39 O

ATOM 10044 N THR D 156 48.513 41.654 4.431 1.00 6.86 N

ATOM 10045 CA THR D 156 49.904 41.209 4.382 1.00 7.22 C

ATOM 10046 CB THR D 156 50.147 40.143 3.282 1.00 7.28 C

ATOM 10047 OGl THR D 156 49.102 39.163 3.312 1.00 7.71 O

ATOM 10048 CG2 THR D 156 51.491 39.450 3.485 1.00 7.19 C

ATOM 10049 C THR D 156 50.834 42.405 4.163 1.00 7.05 C

ATOM 10050 O THR D 156 51.864 42.524 4.833 1.00 7.34 O

ATOM 10051 N VAL D 157 50.450 43.289 3.240 1.00 6.83 N

ATOM 10052 CA VAL D 157 51.208 44.506 2.933 1.00 6.56 C

ATOM 10053 CB VAL D 157 50.555 45.316 1.766 1.00 6.63 C

ATOM 10054 CGl VAL D 157 51.207 46.682 1.612 1.00 6.84 C

ATOM 10055 CG2 VAL D 157 50.650 44.545 0.450 1.00 6.33 C

ATOM 10056 C VAL D 157 51.355 45.384 4.177 1.00 6.77 C

ATOM 10057 O VAL D 157 52.453 45.857 4.483 1.00 6.43 O

ATOM 10058 N LEU D 158 50.244 45.585 4.887 1.00 6.84 N

ATOM 10059 CA LEU D 158 50.227 46.357 6.127 1.00 7.44 C W2025-7029WO / AM102903-PCT

ATOM 10060 CB LEU D 158 48.801 46.422 6.700 1.00 7.29 C

ATOM 10061 CG LEU D 158 48.638 46.976 8.124 1.00 8.40 C

ATOM 10062 CDl LEU D 158 49.013 48.467 8.205 1.00 9.29 C

ATOM 10063 CD2 LEU D 158 47.217 46.735 8.626 1.00 7.36 C

ATOM 10064 C LEU D 158 51.190 45.801 7.176 1.00 7.55 C

ATOM 10065 O LEU D 158 51.985 46.550 7.755 1.00 7.67 O

ATOM 10066 N VAL D 159 51.099 44.491 7.417 1.00 7.78 N

ATOM 10067 CA VAL D 159 51.902 43.819 8.434 1.00 8.21 C

ATOM 10068 CB VAL D 159 51.420 42.358 8.696 1.00 8.16 C

ATOM 10069 CGl VAL D 159 52.333 41.640 9.702 1.00 7.96 C

ATOM 10070 CG2 VAL D 159 49.968 42.348 9.196 1.00 7.25 C

ATOM 10071 C VAL D 159 53.381 43.867 8.056 1.00 8.77 C

ATOM 10072 O VAL D 159 54.225 44.122 8.916 1.00 8.85 O

ATOM 10073 N GLN D 160 53.688 43.643 6.776 1.00 9.38 N

ATOM 10074 CA GLN D 160 55.062 43.778 6.283 1.00 10.56 C

ATOM 10075 CB GLN D 160 55.156 43.463 4.784 1.00 10.51 C

ATOM 10076 CG GLN D 160 56.544 43.747 4.192 1.00 11.91 C

ATOM 10077 CD GLN D 160 56.713 43.266 2.765 1.00 12.42 C

ATOM 10078 OEl GLN D 160 55.814 42.654 2.181 1.00 15.66 O

ATOM 10079 NE2 GLN D 160 57.884 43.536 2.193 1.00 15.51 N

ATOM 10080 C GLN D 160 55.596 45.184 6.560 1.00 10.34 C

ATOM 10081 O GLN D 160 56.684 45.349 7.126 1.00 10.18 O

ATOM 10082 N GLU D 161 54.818 46.188 6.162 1.00 10.37 N

ATOM 10083 CA GLU D 161 55.201 47.584 6.340 1.00 10.67 C

ATOM 10084 CB GLU D 161 54.213 48.518 5.637 1.00 10.39 C

ATOM 10085 CG GLU D 161 54.373 48.555 4.118 1.00 11.13 C

ATOM 10086 CD GLU D 161 53.263 49.333 3.418 1.00 11.02 C

ATOM 10087 OEl GLU D 161 52.337 49.816 4.106 1.00 12.51 O

ATOM 10088 OE2 GLU D 161 53.317 49.462 2.174 1.00 11.87 O

ATOM 10089 C GLU D 161 55.348 47.958 7.814 1.00 10.43 C

ATOM 10090 O GLU D 161 56.252 48.714 8.163 1.00 10.26 O

ATOM 10091 N MET D 162 54.473 47.420 8.667 1.00 10.39 N

ATOM 10092 CA MET D 162 54.553 47.664 10.111 1.00 10.79 C

ATOM 10093 CB MET D 162 53.289 47.184 10.830 1.00 10.68 C

ATOM 10094 CG MET D 162 53.367 47.309 12.344 1.00 10.32 C

ATOM 10095 SD MET D 162 51.770 47.267 13.174 1.00 10.75

ATOM 10096 CE MET D 162 51.102 48.861 12.707 1.00 9.58 C

ATOM 10097 C MET D 162 55.784 46.993 10.717 1.00 11.11 C

ATOM 10098 O MET D 162 56.452 47.561 11.578 1.00 11.12 O

ATOM 10099 N ARG D 163 56.063 45.779 10.254 1.00 11.60 N

ATOM 10100 CA ARG D 163 57.238 45.029 10.670 1.00 12.50 C

ATOM 10101 CB ARG D 163 57.245 43.666 9.965 1.00 12.59 C

ATOM 10102 CG ARG D 163 58.368 42.736 10.347 1.00 13.77 C

ATOM 10103 CD ARG D 163 58.232 42.219 11.761 1.00 14.41 C

ATOM 10104 NE ARG D 163 59.454 41.518 12.130 1.00 15.95 N

ATOM 10105 CZ ARG D 163 59.582 40.196 12.194 1.00 16.25 C

ATOM 10106 NHl ARG D 163 60.753 39.669 12.530 1.00 17.92 N

ATOM 10107 NH2 ARG D 163 58.548 39.403 11.943 1.00 14.50 N

ATOM 10108 C ARG D 163 58.523 45.816 10.392 1.00 12.58 C

ATOM 10109 O ARG D 163 59.378 45.949 11.269 1.00 12.62 O

ATOM 10110 N GLU D 164 58.634 46.359 9.183 1.00 12.96 N

ATOM 10111 CA GLU D 164 59.818 47.109 8.767 1.00 13.58 C

ATOM 10112 CB GLU D 164 59.773 47.386 7.258 1.00 13.85 C

ATOM 10113 CG GLU D 164 59.983 46.129 6.414 1.00 15.27 C

ATOM 10114 CD GLU D 164 59.513 46.266 4.971 1.00 15.20 C

ATOM 10115 OEl GLU D 164 59.822 45.358 4.172 1.00 17.65 O

ATOM 10116 OE2 GLU D 164 58.835 47.263 4.628 1.00 18.61 O

ATOM 10117 C GLU D 164 59.988 48.405 9.565 1.00 13.08 C

ATOM 10118 O GLU D 164 61.096 48.736 10.000 1.00 12.81 O

ATOM 10119 N ALA D 165 58.883 49.118 9.767 1.00 12.61 N

ATOM 10120 CA ALA D 165 58.878 50.336 10.570 1.00 12.31 C

ATOM 10121 CB ALA D 165 57.500 50.989 10.537 1.00 12.14 C

ATOM 10122 C ALA D 165 59.324 50.074 12.013 1.00 12.08 C W2025-7029WO / AM102903-PCT

ATOM 10123 O ALA D 165 60.111 50.838 12.560 1.00 12.15 O

ATOM 10124 N PHE D 166 58.821 48.989 12.606 1.00 12.13 N

ATOM 10125 CA PHE D 166 59.165 48.582 13.978 1.00 11.96 C

ATOM 10126 CB PHE D 166 58.326 47.364 14.406 1.00 11.57 C

ATOM 10127 CG PHE D 166 56.913 47.697 14.847 1.00 11.01 C

ATOM 10128 CDl PHE D 166 56.405 48.992 14.748 1.00 10.21 C

ATOM 10129 CEl PHE D 166 55.094 49.284 15.157 1.00 10.12 C

ATOM 10130 CZ PHE D 166 54.278 48.275 15.653 1.00 9.86 C

ATOM 10131 CE2 PHE D 166 54.766 46.969 15.738 1.00 10.09 C

ATOM 10132 CD2 PHE D 166 56.074 46.690 15.330 1.00 10.60 C

ATOM 10133 C PHE D 166 60.658 48.265 14.122 1.00 12.38 C

ATOM 10134 O PHE D 166 61.299 48.681 15.096 1.00 11.94 O

ATOM 10135 N GLU D 167 61.195 47.533 13.145 1.00 12.84 N

ATOM 10136 CA GLU D 167 62.605 47.136 13.122 1.00 13.56 C

ATOM 10137 CB GLU D 167 62.868 46.156 11.974 1.00 13.42 C

ATOM 10138 CG GLU D 167 62.172 44.807 12.136 1.00 13.53 C

ATOM 10139 CD GLU D 167 62.224 43.948 10.883 1.00 13.73 C

ATOM 10140 OEl GLU D 167 62.815 44.384 9.873 1.00 15.20 O

ATOM 10141 OE2 GLU D 167 61.678 42.826 10.912 1.00 13.70 O

ATOM 10142 C GLU D 167 63.533 48.340 12.994 1.00 14.03 C

ATOM 10143 O GLU D 167 64.592 48.388 13.630 1.00 13.90 O

ATOM 10144 N GLN D 168 63.124 49.298 12.163 1.00 14.63 N

ATOM 10145 CA GLN D 168 63.855 50.548 11.965 1.00 15.28 C

ATOM 10146 CB GLN D 168 63.268 51.329 10.784 1.00 15.69 C

ATOM 10147 CG GLN D 168 63.794 50.887 9.414 1.00 18.39 C

ATOM 10148 CD GLN D 168 65.139 51.528 9.046 1.00 22.21 C

ATOM 10149 OEl GLN D 168 65.388 52.708 9.329 1.00 23.98 O

ATOM 10150 NE2 GLN D 168 66.003 50.752 8.391 1.00 23.42 N

ATOM 10151 C GLN D 168 63.845 51.399 13.232 1.00 15.20 C

ATOM 10152 O GLN D 168 64.892 51.896 13.659 1.00 15.35 O

ATOM 10153 N GLU D 169 62.664 51.540 13.837 1.00 14.93 N

ATOM 10154 CA GLU D 169 62.496 52.276 15.095 1.00 14.71 C

ATOM 10155 CB GLU D 169 61.014 52.341 15.479 1.00 14.51 C

ATOM 10156 CG GLU D 169 60.693 53.269 16.660 1.00 14.16 C

ATOM 10157 CD GLU D 169 60.645 52.554 18.000 1.00 12.31 C

ATOM 10158 OEl GLU D 169 61.031 51.369 18.078 1.00 13.06 O

ATOM 10159 OE2 GLU D 169 60.212 53.180 18.986 1.00 11.82 O

ATOM 10160 C GLU D 169 63.326 51.675 16.239 1.00 15.00 C

ATOM 10161 O GLU D 169 63.887 52.409 17.055 1.00 14.71 O

ATOM 10162 N ALA D 170 63.388 50.345 16.288 1.00 15.22 N

ATOM 10163 CA ALA D 170 64.157 49.622 17.299 1.00 16.01 C

ATOM 10164 CB ALA D 170 63.989 48.120 17.114 1.00 16.02 C

ATOM 10165 C ALA D 170 65.637 49.994 17.262 1.00 16.50 C

ATOM 10166 O ALA D 170 66.252 50.209 18.309 1.00 16.60 O

ATOM 10167 N LYS D 171 66.193 50.068 16.055 1.00 17.08 N

ATOM 10168 CA LYS D 171 67.593 50.441 15.863 1.00 18.04 C

ATOM 10169 CB LYS D 171 68.075 50.058 14.457 1.00 18.44 C

ATOM 10170 CG LYS D 171 68.001 48.565 14.108 1.00 19.27 C

ATOM 10171 CD LYS D 171 69.087 47.719 14.805 1.00 21.20 C

ATOM 10172 CE LYS D 171 69.065 46.260 14.312 1.00 21.28 C

ATOM 10173 NZ LYS D 171 69.774 45.307 15.225 1.00 21.84 N

ATOM 10174 C LYS D 171 67.818 51.940 16.111 1.00 18.44 C

ATOM 10175 O LYS D 171 68.901 52.344 16.552 1.00 18.50 O

ATOM 10176 N GLN D 172 66.795 52.750 15.827 1.00 18.75 N

ATOM 10177 CA GLN D 172 66.840 54.201 16.049 1.00 19.42 C

ATOM 10178 CB GLN D 172 65.607 54.888 15.448 1.00 19.50 C

ATOM 10179 CG GLN D 172 65.621 55.032 13.927 1.00 20.46 C

ATOM 10180 CD GLN D 172 64.328 55.624 13.369 1.00 20.63 C

ATOM 10181 OEl GLN D 172 63.290 55.644 14.038 1.00 22.76 O

ATOM 10182 NE2 GLN D 172 64.390 56.109 12.132 1.00 23.07 N

ATOM 10183 C GLN D 172 66.934 54.572 17.525 1.00 19.19 C

ATOM 10184 O GLN D 172 67.685 55.480 17.889 1.00 19.39 O

ATOM 10185 N ILE D 173 66.166 53.882 18.368 1.00 18.93 N W2025-7029WO / AM102903-PCT

ATOM 10186 CA ILE D 173 66.092 54.233 19.793 1.00 18.72 C

ATOM 10187 CB ILE D 173 64.625 54.430 20.280 1.00 18.62 C

ATOM 10188 CGl ILE D 173 63.890 53.089 20.420 1.00 18.47 C

ATOM 10189 CDl ILE D 173 62.606 53.178 21.244 1.00 18.75 C

ATOM 10190 CG2 ILE D 173 63.882 55.396 19.350 1.00 19.27 C

ATOM 10191 C ILE D 173 66.861 53.293 20.728 1.00 18.57 C

ATOM 10192 O ILE D 173 66.888 53.508 21.945 1.00 18.72 O

ATOM 10193 N ASN D 174 67.492 52.269 20.150 1.00 18.36 N

ATOM 10194 CA ASN D 174 68.308 51.297 20.892 1.00 18.17 C

ATOM 10195 CB ASN D 174 69.561 51.976 21.482 1.00 18.53 C

ATOM 10196 CG ASN D 174 70.594 50.981 21.997 1.00 19.98 C

ATOM 10197 ODl ASN D 174 70.613 49.809 21.605 1.00 22.15 O

ATOM 10198 ND2 ASN D 174 71.471 51.453 22.881 1.00 21.20 N

ATOM 10199 C ASN D 174 67.493 50.550 21.962 1.00 17.66 C

ATOM 10200 O ASN D 174 67.876 50.482 23.137 1.00 17.59 O

ATOM 10201 N LYS D 175 66.353 50.010 21.537 1.00 16.71 N

ATOM 10202 CA LYS D 175 65.478 49.220 22.403 1.00 16.28 C

ATOM 10203 CB LYS D 175 64.298 50.065 22.901 1.00 16.20 C

ATOM 10204 CG LYS D 175 64.647 51.091 23.979 1.00 16.89 C

ATOM 10205 CD LYS D 175 63.396 51.802 24.471 1.00 17.52 C

ATOM 10206 CE LYS D 175 63.719 52.917 25.444 1.00 19.52 C

ATOM 10207 NZ LYS D 175 62.472 53.624 25.851 1.00 20.99 N

ATOM 10208 C LYS D 175 64.962 48.010 21.619 1.00 15.19 C

ATOM 10209 O LYS D 175 64.931 48.054 20.388 1.00 15.12 O

ATOM 10210 N PRO D 176 64.585 46.919 22.321 1.00 14.40 N

ATOM 10211 CA PRO D 176 63.888 45.810 21.665 1.00 13.60 C

ATOM 10212 CB PRO D 176 63.370 44.984 22.843 1.00 13.53 C

ATOM 10213 CG PRO D 176 64.394 45.201 23.906 1.00 14.33 C

ATOM 10214 CD PRO D 176 64.835 46.633 23.749 1.00 14.31 C

ATOM 10215 C PRO D 176 62.722 46.281 20.795 1.00 12.82 C

ATOM 10216 O PRO D 176 61.995 47.200 21.172 1.00 12.80 O

ATOM 10217 N ARG D 177 62.568 45.641 19.640 1.00 12.22 N

ATOM 10218 CA ARG D 177 61.531 45.967 18.657 1.00 11.70 C

ATOM 10219 CB ARG D 177 61.780 45.159 17.366 1.00 12.00 C

ATOM 10220 CG ARG D 177 60.533 44.722 16.611 1.00 12.00 C

ATOM 10221 CD ARG D 177 60.825 44.032 15.286 1.00 11.52 C

ATOM 10222 NE ARG D 177 60.916 42.573 15.370 1.00 11.15 N

ATOM 10223 CZ ARG D 177 59.882 41.744 15.525 1.00 11.51 C

ATOM 10224 NHl ARG D 177 58.643 42.208 15.654 1.00 10.44 N

ATOM 10225 NH2 ARG D 177 60.095 40.432 15.573 1.00 11.64 N

ATOM 10226 C ARG D 177 60.121 45.709 19.194 1.00 11.24 C

ATOM 10227 O ARG D 177 59.909 44.779 19.975 1.00 11.08 O

ATOM 10228 N LEU D 178 59.166 46.540 18.778 1.00 10.63 N

ATOM 10229 CA LEU D 178 57.762 46.296 19.100 1.00 10.20 C

ATOM 10230 CB LEU D 178 56.888 47.507 18.748 1.00 9.91 C

ATOM 10231 CG LEU D 178 57.149 48.788 19.557 1.00 9.64 C

ATOM 10232 CDl LEU D 178 56.697 50.035 18.803 1.00 8.25 C

ATOM 10233 CD2 LEU D 178 56.514 48.727 20.947 1.00 8.56 C

ATOM 10234 C LEU D 178 57.284 45.051 18.360 1.00 9.88 C

ATOM 10235 O LEU D 178 57.683 44.797 17.227 1.00 9.60 O

ATOM 10236 N MET D 179 56.447 44.271 19.025 1.00 9.75 N

ATOM 10237 CA MET D 179 55.860 43.082 18.433 1.00 9.96 C

ATOM 10238 CB MET D 179 55.433 42.118 19.536 1.00 9.61 C

ATOM 10239 CG MET D 179 56.572 41.300 20.135 1.00 11.26 C

ATOM 10240 SD MET D 179 56.013 40.169 21.425 1.00 12.37

ATOM 10241 CE MET D 179 54.564 39.443 20.668 1.00 14.09 C

ATOM 10242 C MET D 179 54.654 43.420 17.554 1.00 8.94 C

ATOM 10243 O MET D 179 53.945 44.393 17.808 1.00 8.84 O

ATOM 10244 N VAL D 180 54.433 42.608 16.523 1.00 8.40 N

ATOM 10245 CA VAL D 180 53.195 42.657 15.740 1.00 7.38 C

ATOM 10246 CB VAL D 180 53.395 43.292 14.321 1.00 7.36 C

ATOM 10247 CGl VAL D 180 54.418 42.524 13.476 1.00 7.38 C

ATOM 10248 CG2 VAL D 180 52.049 43.441 13.583 1.00 7.28 C W2025-7029WO / AM102903-PCT

ATOM 10249 C VAL D 180 52.532 41.273 15.695 1.00 7.05 C

ATOM 10250 O VAL D 180 53.125 40.294 15.231 1.00 6.78 O

ATOM 10251 N THR D 181 51.312 41.195 16.221 1.00 6.24 N

ATOM 10252 CA THR D 181 50.556 39.943 16.236 1.00 5.53 C

ATOM 10253 CB THR D 181 50.410 39.364 17.667 1.00 5.37 C

ATOM 10254 OGl THR D 181 49.605 40.241 18.457 1.00 4.78 O

ATOM 10255 CG2 THR D 181 51.775 39.159 18.336 1.00 5.42 C

ATOM 10256 C THR D 181 49.165 40.143 15.644 1.00 5.11 C

ATOM 10257 O THR D 181 48.768 41.273 15.348 1.00 4.86 O

ATOM 10258 N ALA D 182 48.425 39.046 15.482 1.00 4.87 N

ATOM 10259 CA ALA D 182 47.050 39.108 14.971 1.00 4.68 C

ATOM 10260 CB ALA D 182 47.051 39.041 13.451 1.00 4.45 C

ATOM 10261 C ALA D 182 46.141 38.019 15.554 1.00 4.78 C

ATOM 10262 O ALA D 182 46.534 36.847 15.628 1.00 4.63 O

ATOM 10263 N ALA D 183 44.945 38.419 15.996 1.00 4.51 N

ATOM 10264 CA ALA D 183 43.860 37.471 16.235 1.00 4.51 C

ATOM 10265 CB ALA D 183 42.810 38.050 17.179 1.00 4.32 C

ATOM 10266 C ALA D 183 43.239 37.142 14.884 1.00 4.52 C

ATOM 10267 O ALA D 183 42.867 38.049 14.131 1.00 4.81 O

ATOM 10268 N VAL D 184 43.130 35.850 14.580 1.00 4.73 N

ATOM 10269 CA VAL D 184 42.714 35.395 13.248 1.00 4.55 C

ATOM 10270 CB VAL D 184 43.883 34.702 12.491 1.00 4.78 C

ATOM 10271 CGl VAL D 184 45.032 35.687 12.225 1.00 4.17 C

ATOM 10272 CG2 VAL D 184 44.377 33.474 13.263 1.00 3.96 C

ATOM 10273 C VAL D 184 41.514 34.447 13.294 1.00 4.83 C

ATOM 10274 O VAL D 184 41.260 33.803 14.315 1.00 4.79 O

ATOM 10275 N ALA D 185 40.800 34.360 12.170 1.00 5.15 N

ATOM 10276 CA ALA D 185 39.602 33.516 12.033 1.00 5.40 C

ATOM 10277 CB ALA D 185 38.950 33.749 10.667 1.00 5.41 C

ATOM 10278 C ALA D 185 39.856 32.019 12.234 1.00 5.65 C

ATOM 10279 O ALA D 185 40.926 31.505 11.888 1.00 5.21 O

ATOM 10280 N ALA D 186 38.853 31.339 12.791 1.00 5.47 N

ATOM 10281 CA ALA D 186 38.835 29.878 12.887 1.00 5.99 C

ATOM 10282 CB ALA D 186 38.386 29.437 14.293 1.00 5.56 C

ATOM 10283 C ALA D 186 37.943 29.232 11.812 1.00 6.06 C

ATOM 10284 O ALA D 186 38.090 28.049 11.505 1.00 6.12 O

ATOM 10285 N GLY D 187 37.012 30.007 11.257 1.00 6.12 N

ATOM 10286 CA GLY D 187 36.094 29.509 10.226 1.00 6.19 C

ATOM 10287 C GLY D 187 36.797 29.358 8.890 1.00 6.45 C

ATOM 10288 O GLY D 187 37.379 30.317 8.391 1.00 6.19 O

ATOM 10289 N ILE D 188 36.734 28.155 8.308 1.00 6.64 N

ATOM 10290 CA ILE D 188 37.505 27.833 7.093 1.00 6.91 C

ATOM 10291 CB ILE D 188 37.302 26.355 6.624 1.00 7.02 C

ATOM 10292 CGl ILE D 188 37.689 25.354 7.727 1.00 7.14 C

ATOM 10293 CDl ILE D 188 39.109 25.501 8.295 1.00 6.78 C

ATOM 10294 CG2 ILE D 188 38.091 26.068 5.333 1.00 7.53 C

ATOM 10295 C ILE D 188 37.253 28.812 5.940 1.00 7.08 C

ATOM 10296 O ILE D 188 38.198 29.251 5.282 1.00 7.09 O

ATOM 10297 N SER D 189 35.990 29.163 5.703 1.00 6.94 N

ATOM 10298 CA SER D 189 35.669 30.129 4.652 1.00 7.06 C

ATOM 10299 CB SER D 189 34.152 30.306 4.499 1.00 7.35 C

ATOM 10300 OG SER D 189 33.861 31.280 3.504 1.00 9.24 O

ATOM 10301 C SER D 189 36.354 31.472 4.909 1.00 6.70 C

ATOM 10302 O SER D 189 37.002 32.017 4.017 1.00 6.62 O

ATOM 10303 N ASN D 190 36.228 31.981 6.135 1.00 6.29 N

ATOM 10304 CA ASN D 190 36.833 33.259 6.524 1.00 6.39 C

ATOM 10305 CB ASN D 190 36.374 33.683 7.925 1.00 6.29 C

ATOM 10306 CG ASN D 190 34.922 34.147 7.960 1.00 7.10 C

ATOM 10307 ODl ASN D 190 34.300 34.399 6.923 1.00 6.64 O

ATOM 10308 ND2 ASN D 190 34.377 34.261 9.164 1.00 7.66 N

ATOM 10309 C ASN D 190 38.359 33.259 6.460 1.00 6.33 C

ATOM 10310 O ASN D 190 38.963 34.291 6.179 1.00 6.40 O

ATOM 10311 N ILE D 191 38.969 32.106 6.736 1.00 6.45 N W2025-7029WO / AM102903-PCT

ATOM 10312 CA ILE D 191 40.422 31.937 6.619 1.00 6.42 C

ATOM 10313 CB ILE D 191 40.888 30.585 7.225 1.00 6.35 C

ATOM 10314 CGl ILE D 191 40.605 30.545 8.730 1.00 5.93 C

ATOM 10315 CDl ILE D 191 40.629 29.142 9.337 1.00 6.22 C

ATOM 10316 CG2 ILE D 191 42.380 30.340 6.947 1.00 6.52 C

ATOM 10317 C ILE D 191 40.850 32.038 5.150 1.00 6.73 C

ATOM 10318 O ILE D 191 41.808 32.750 4.817 1.00 6.67 O

ATOM 10319 N GLN D 192 40.124 31.332 4.281 1.00 6.68 N

ATOM 10320 CA GLN D 192 40.423 31.307 2.846 1.00 7.00 C

ATOM 10321 CB GLN D 192 39.600 30.220 2.143 1.00 7.05 C

ATOM 10322 CG GLN D 192 39.999 28.792 2.545 1.00 7.12 C

ATOM 10323 CD GLN D 192 39.124 27.710 1.915 1.00 8.24 C

ATOM 10324 OEl GLN D 192 37.996 27.966 1.482 1.00 9.76 O

ATOM 10325 NE2 GLN D 192 39.646 26.484 1.873 1.00 9.77 N

ATOM 10326 C GLN D 192 40.245 32.673 2.166 1.00 6.68 C

ATOM 10327 O GLN D 192 41.024 33.037 1.280 1.00 6.80 O

ATOM 10328 N SER D 193 39.232 33.428 2.586 1.00 6.30 N

ATOM 10329 CA SER D 193 38.996 34.764 2.023 1.00 6.38 C

ATOM 10330 CB SER D 193 37.494 35.097 1.998 1.00 6.14 C

ATOM 10331 OG SER D 193 36.951 35.160 3.305 1.00 7.29 O

ATOM 10332 C SER D 193 39.784 35.869 2.734 1.00 6.02 C

ATOM 10333 O SER D 193 39.853 36.994 2.246 1.00 6.34 O

ATOM 10334 N GLY D 194 40.395 35.544 3.870 1.00 5.93 N

ATOM 10335 CA GLY D 194 40.997 36.559 4.732 1.00 6.05 C

ATOM 10336 C GLY D 194 42.502 36.744 4.703 1.00 6.10 C

ATOM 10337 O GLY D 194 42.989 37.873 4.813 1.00 6.14 O

ATOM 10338 N TYR D 195 43.247 35.649 4.558 1.00 6.13 N

ATOM 10339 CA TYR D 195 44.681 35.683 4.834 1.00 5.87 C

ATOM 10340 CB TYR D 195 44.958 35.120 6.235 1.00 5.86 C

ATOM 10341 CG TYR D 195 43.961 35.529 7.310 1.00 6.39 C

ATOM 10342 CDl TYR D 195 42.840 34.741 7.588 1.00 5.07 C

ATOM 10343 CEl TYR D 195 41.925 35.106 8.572 1.00 5.53 C

ATOM 10344 C Z TYR D 195 42.135 36.262 9.302 1.00 6.06 C

ATOM 10345 OH TYR D 195 41.235 36.631 10.281 1.00 5.97 O

ATOM 10346 CE2 TYR D 195 43.241 37.063 9.048 1.00 6.28 C

ATOM 10347 CD2 TYR D 195 44.148 36.695 8.059 1.00 6.01 C

ATOM 10348 C TYR D 195 45.543 34.936 3.816 1.00 5.93 C

ATOM 10349 O TYR D 195 45.192 33.838 3.362 1.00 5.53 O

ATOM 10350 N GLU D 196 46.685 35.538 3.483 1.00 5.60 N

ATOM 10351 CA GLU D 196 47.721 34.873 2.707 1.00 5.67 C

ATOM 10352 CB GLU D 196 48.493 35.881 1.845 1.00 5.55 C

ATOM 10353 CG GLU D 196 47.624 36.770 0.941 1.00 5.36 C

ATOM 10354 CD GLU D 196 48.448 37.722 0.079 1.00 6.08 C

ATOM 10355 OEl GLU D 196 48.308 37.671 -1.159 1.00 7.36 O

ATOM 10356 OE2 GLU D 196 49.241 38.519 0.630 1.00 5.91 O

ATOM 10357 C GLU D 196 48.641 34.211 3.730 1.00 5.68 C

ATOM 10358 O GLU D 196 49.641 34.805 4.157 1.00 5.66 O

ATOM 10359 N ILE D 197 48.282 32.993 4.140 1.00 5.55 N

ATOM 10360 CA ILE D 197 48.918 32.335 5.295 1.00 5.67 C

ATOM 10361 CB ILE D 197 48.253 30.968 5.649 1.00 5.77 C

ATOM 10362 CGl ILE D 197 46.758 31.156 5.942 1.00 5.38 C

ATOM 10363 CDl ILE D 197 45.973 29.868 6.021 1.00 5.73 C

ATOM 10364 CG2 ILE D 197 48.966 30.305 6.846 1.00 6.32 C

ATOM 10365 C ILE D 197 50.455 32.204 5.216 1.00 5.69 C

ATOM 10366 O ILE D 197 51.144 32.572 6.178 1.00 5.41 O

ATOM 10367 N PRO D 198 51.002 31.700 4.084 1.00 5.52 N

ATOM 10368 CA PRO D 198 52.464 31.534 4.086 1.00 5.60 C

ATOM 10369 CB PRO D 198 52.771 31.039 2.664 1.00 5.63 C

ATOM 10370 CG PRO D 198 51.496 30.427 2.195 1.00 5.43 C

ATOM 10371 CD PRO D 198 50.411 31.276 2.799 1.00 5.56 C

ATOM 10372 C PRO D 198 53.223 32.833 4.399 1.00 5.58 C

ATOM 10373 O PRO D 198 54.013 32.860 5.344 1.00 5.69 O

ATOM 10374 N GLN D 199 52.970 33.898 3.637 1.00 5.65 N W2025-7029WO / AM102903-PCT

ATOM 10375 CA GLN D 199 53.725 35.148 3.804 1.00 5.67 C

ATOM 10376 CB GLN D 199 53.618 36.059 2.572 1.00 5.93 C

ATOM 10377 CG GLN D 199 54.585 37.245 2.604 1.00 5.78 C

ATOM 10378 CD GLN D 199 56.050 36.807 2.640 1.00 7.45 C

ATOM 10379 OEl GLN D 199 56.674 36.604 1.597 1.00 7.94 O

ATOM 10380 NE2 GLN D 199 56.600 36.658 3.845 1.00 6.11 N

ATOM 10381 C GLN D 199 53.371 35.919 5.075 1.00 5.65 C

ATOM 10382 O GLN D 199 54.264 36.426 5.751 1.00 5.56 O

ATOM 10383 N LEU D 200 52.077 35.997 5.390 1.00 5.25 N

ATOM 10384 CA LEU D 200 51.605 36.661 6.614 1.00 5.38 C

ATOM 10385 CB LEU D 200 50.065 36.652 6.678 1.00 5.25 C

ATOM 10386 CG LEU D 200 49.360 37.351 7.847 1.00 5.36 C

ATOM 10387 CDl LEU D 200 49.469 38.886 7.751 1.00 5.42 C

ATOM 10388 CD2 LEU D 200 47.908 36.925 7.914 1.00 5.18 C

ATOM 10389 C LEU D 200 52.191 36.055 7.891 1.00 5.53 C

ATOM 10390 O LEU D 200 52.618 36.785 8.790 1.00 5.37 O

ATOM 10391 N SER D 201 52.214 34.722 7.961 1.00 5.65 N

ATOM 10392 CA SER D 201 52.706 34.016 9.143 1.00 6.11 C

ATOM 10393 CB SER D 201 52.430 32.509 9.048 1.00 6.01 C

ATOM 10394 OG SER D 201 51.055 32.226 8.819 1.00 7.14 O

ATOM 10395 C SER D 201 54.199 34.257 9.393 1.00 6.36 C

ATOM 10396 O SER D 201 54.645 34.218 10.530 1.00 6.42 O

ATOM 10397 N GLN D 202 54.960 34.502 8.329 1.00 6.71 N

ATOM 10398 CA GLN D 202 56.393 34.767 8.449 1.00 7.16 C

ATOM 10399 CB GLN D 202 57.080 34.664 7.077 1.00 6.90 C

ATOM 10400 CG GLN D 202 57.178 33.228 6.514 1.00 7.00 C

ATOM 10401 CD GLN D 202 57.988 32.285 7.406 1.00 6.98 C

ATOM 10402 OEl GLN D 202 59.020 32.667 7.953 1.00 6.42 O

ATOM 10403 NE2 GLN D 202 57.512 31.050 7.559 1.00 5.75 N

ATOM 10404 C GLN D 202 56.669 36.129 9.093 1.00 7.35 C

ATOM 10405 O GLN D 202 57.653 36.298 9.800 1.00 7.75 O

ATOM 10406 N TYR D 203 55.778 37.089 8.864 1.00 7.81 N

ATOM 10407 CA TYR D 203 55.986 38.453 9.341 1.00 8.19 C

ATOM 10408 CB TYR D 203 55.551 39.467 8.278 1.00 8.33 C

ATOM 10409 CG TYR D 203 56.462 39.504 7.063 1.00 9.12 C

ATOM 10410 CDl TYR D 203 55.985 39.921 5.819 1.00 9.03 C

ATOM 10411 CEl TYR D 203 56.827 39.964 4.700 1.00 9.09 C

ATOM 10412 CZ TYR D 203 58.155 39.568 4.820 1.00 9.58 C

ATOM 10413 OH TYR D 203 58.993 39.600 3.725 1.00 10.30 O

ATOM 10414 CE2 TYR D 203 58.650 39.135 6.042 1.00 10.02 C

ATOM 10415 CD2 TYR D 203 57.805 39.107 7.155 1.00 10.36 C

ATOM 10416 C TYR D 203 55.359 38.753 10.709 1.00 7.98 C

ATOM 10417 O TYR D 203 55.874 39.581 11.460 1.00 8.20 O

ATOM 10418 N LEU D 204 54.261 38.071 11.026 1.00 7.75 N

ATOM 10419 CA LEU D 204 53.644 38.151 12.347 1.00 7.41 C

ATOM 10420 CB LEU D 204 52.260 37.504 12.326 1.00 7.38 C

ATOM 10421 CG LEU D 204 51.099 38.233 11.646 1.00 7.10 C

ATOM 10422 CDl LEU D 204 49.902 37.305 11.568 1.00 5.84 C

ATOM 10423 CD2 LEU D 204 50.748 39.512 12.415 1.00 6.72 C

ATOM 10424 C LEU D 204 54.506 37.435 13.377 1.00 7.39 C

ATOM 10425 O LEU D 204 55.093 36.398 13.078 1.00 7.26 O

ATOM 10426 N ASP D 205 54.581 37.984 14.585 1.00 7.12 N

ATOM 10427 CA ASP D 205 55.310 37.325 15.674 1.00 7.35 C

ATOM 10428 CB ASP D 205 55.695 38.334 16.756 1.00 7.53 C

ATOM 10429 CG ASP D 205 56.709 39.338 16.260 1.00 8.32 C

ATOM 10430 ODl ASP D 205 57.770 38.905 15.765 1.00 9.83 O

ATOM 10431 OD2 ASP D 205 56.439 40.553 16.338 1.00 8.99 O

ATOM 10432 C ASP D 205 54.528 36.156 16.268 1.00 7.15 C

ATOM 10433 O ASP D 205 55.101 35.105 16.565 1.00 6.77 O

ATOM 10434 N TYR D 206 53.220 36.348 16.436 1.00 6.89 N

ATOM 10435 CA TYR D 206 52.331 35.289 16.914 1.00 6.82 C

ATOM 10436 CB TYR D 206 52.146 35.357 18.433 1.00 7.34 C

ATOM 10437 CG TYR D 206 53.409 35.072 19.216 1.00 7.92 C W2025-7029WO / AM102903-PCT

ATOM 10438 CDl TYR D 206 54.163 36.112 19.747 1.00 8.55 C

ATOM 10439 CEl TYR D 206 55.339 35.866 20.454 1.00 8.69 C

ATOM 10440 CZ TYR D 206 55.763 34.560 20.637 1.00 8.95 C

ATOM 10441 OH TYR D 206 56.921 34.321 21.350 1.00 9.80 O

ATOM 10442 CE2 TYR D 206 55.031 33.499 20.117 1.00 8.49 C

ATOM 10443 CD2 TYR D 206 53.860 33.759 19.409 1.00 8.08 C

ATOM 10444 C TYR D 206 50.978 35.355 16.216 1.00 6.42 C

ATOM 10445 O TYR D 206 50.511 36.436 15.841 1.00 6.31 O

ATOM 10446 N ILE D 207 50.371 34.183 16.041 1.00 5.93 N

ATOM 10447 CA ILE D 207 49.075 34.043 15.378 1.00 5.55 C

ATOM 10448 CB ILE D 207 49.195 33.089 14.163 1.00 5.51 C

ATOM 10449 CGl ILE D 207 50.319 33.558 13.233 1.00 5.30 C

ATOM 10450 CDl ILE D 207 50.884 32.472 12.321 1.00 5.14 C

ATOM 10451 CG2 ILE D 207 47.874 32.984 13.397 1.00 5.21 C

ATOM 10452 C ILE D 207 48.050 33.524 16.396 1.00 5.55 C

ATOM 10453 O ILE D 207 48.108 32.365 16.809 1.00 5.55 O

ATOM 10454 N HIS D 208 47.127 34.395 16.802 1.00 5.46 N

ATOM 10455 CA HIS D 208 46.145 34.076 17.843 1.00 5.31 C

ATOM 10456 CB HIS D 208 45.903 35.292 18.747 1.00 5.16 C

ATOM 10457 CG HIS D 208 47.146 35.839 19.381 1.00 5.25 C

ATOM 10458 NDl HIS D 208 47.438 37.187 19.404 1.00 4.71 N

ATOM 10459 CEl HIS D 208 48.586 37.376 20.034 1.00 5.69 C

ATOM 10460 NE2 HIS D 208 49.052 36.200 20.415 1.00 6.23 N

ATOM 10461 CD2 HIS D 208 48.169 35.221 20.020 1.00 4.63 C

ATOM 10462 C HIS D 208 44.831 33.578 17.235 1.00 5.29 C

ATOM 10463 O HIS D 208 43.948 34.367 16.903 1.00 5.17 O

ATOM 10464 N VAL D 209 44.717 32.261 17.093 1.00 5.16 N

ATOM 10465 CA VAL D 209 43.593 31.647 16.397 1.00 5.04 C

ATOM 10466 CB VAL D 209 43.943 30.230 15.877 1.00 5.19 C

ATOM 10467 CGl VAL D 209 42.852 29.723 14.945 1.00 4.34 C

ATOM 10468 CG2 VAL D 209 45.292 30.231 15.172 1.00 4.32 C

ATOM 10469 C VAL D 209 42.377 31.575 17.310 1.00 5.28 C

ATOM 10470 O VAL D 209 42.419 30.939 18.363 1.00 4.97 O

ATOM 10471 N MET D 210 41.295 32.224 16.889 1.00 5.71 N

ATOM 10472 CA MET D 210 40.082 32.329 17.701 1.00 6.48 C

ATOM 10473 CB MET D 210 39.270 33.564 17.289 1.00 6.23 C

ATOM 10474 CG MET D 210 40.001 34.882 17.579 1.00 6.38 C

ATOM 10475 SD MET D 210 39.138 36.361 17.020 1.00 8.56 S

ATOM 10476 CE MET D 210 39.646 36.439 15.320 1.00 8.65 C

ATOM 10477 C MET D 210 39.241 31.048 17.659 1.00 6.21 C

ATOM 10478 O MET D 210 38.106 31.047 17.169 1.00 6.12 O

ATOM 10479 N THR D 211 39.808 29.965 18.195 1.00 6.09 N

ATOM 10480 CA THR D 211 39.158 28.650 18.203 1.00 6.01 C

ATOM 10481 CB THR D 211 40.165 27.489 18.365 1.00 6.15 C

ATOM 10482 OGl THR D 211 41.125 27.813 19.376 1.00 5.22 O

ATOM 10483 CG2 THR D 211 40.889 27.204 17.040 1.00 6.54 C

ATOM 10484 C THR D 211 38.088 28.555 19.285 1.00 6.17 C

ATOM 10485 O THR D 211 38.174 27.744 20.211 1.00 6.06 O

ATOM 10486 N TYR D 212 37.075 29.402 19.149 1.00 6.17 N

ATOM 10487 CA TYR D 212 35.909 29.395 20.029 1.00 6.02 C

ATOM 10488 CB TYR D 212 36.194 30.129 21.354 1.00 5.85 C

ATOM 10489 CG TYR D 212 37.104 31.340 21.267 1.00 6.07 C

ATOM 10490 CDl TYR D 212 36.645 32.545 20.725 1.00 5.66 C

ATOM 10491 CEl TYR D 212 37.474 33.676 20.654 1.00 6.19 C

ATOM 10492 CZ TYR D 212 38.767 33.615 21.142 1.00 6.06 C

ATOM 10493 OH TYR D 212 39.559 34.743 21.070 1.00 7.02 O

ATOM 10494 CE2 TYR D 212 39.252 32.433 21.702 1.00 6.35 C

ATOM 10495 CD2 TYR D 212 38.416 31.297 21.761 1.00 5.30 C

ATOM 10496 C TYR D 212 34.727 29.987 19.267 1.00 5.83 C

ATOM 10497 O TYR D 212 34.904 30.452 18.140 1.00 5.71 O

ATOM 10498 N ASP D 213 33.535 29.961 19.867 1.00 5.77 N

ATOM 10499 CA ASP D 213 32.277 30.314 19.181 1.00 6.09 C

ATOM 10500 CB ASP D 213 32 229 31.802 18.793 1.00 6.01 C W2025-7029WO / AM102903-PCT

ATOM 10501 CG ASP D 213 32.616 32.722 19.935 1.00 6.57 C

ATOM 10502 ODl ASP D 213 32.065 32.564 21.052 1.00 5.58 O

ATOM 10503 OD2 ASP D 213 33.467 33.613 19.706 1.00 5.31 O

ATOM 10504 C ASP D 213 32.032 29.438 17.946 1.00 6.25 C

ATOM 10505 O ASP D 213 31.428 29.881 16.956 1.00 6.33 O

ATOM 10506 N LEU D 214 32.498 28.194 18.024 1.00 6.44 N

ATOM 10507 CA LEU D 214 32.433 27.240 16.908 1.00 7.13 C

ATOM 10508 CB LEU D 214 33.454 26.110 17.112 1.00 6.71 C

ATOM 10509 CG LEU D 214 34.923 26.571 17.140 1.00 7.27 C

ATOM 10510 CDl LEU D 214 35.845 25.460 17.600 1.00 8.16 C

ATOM 10511 CD2 LEU D 214 35.375 27.115 15.784 1.00 7.85 C

ATOM 10512 C LEU D 214 31.030 26.678 16.722 1.00 7.39 C

ATOM 10513 O LEU D 214 30.676 26.224 15.631 1.00 7.45 O

ATOM 10514 N HIS D 215 30.251 26.705 17.802 1.00 7.84 N

ATOM 10515 CA HIS D 215 28.849 26.292 17.803 1.00 8.25 C

ATOM 10516 CB HIS D 215 28.685 24.833 18.269 1.00 8.34 C

ATOM 10517 CG HIS D 215 29.345 23.827 17.376 1.00 8.52 C

ATOM 10518 NDl HIS D 215 28.800 23.421 16.176 1.00 9.65 N

ATOM 10519 CEl HIS D 215 29.602 22.540 15.604 1.00 8.13 C

ATOM 10520 NE2 HIS D 215 30.646 22.356 16.391 1.00 8.69 N

ATOM 10521 CD2 HIS D 215 30.511 23.150 17.505 1.00 8.51 C

ATOM 10522 C HIS D 215 28.068 27.221 18.729 1.00 8.67 C

ATOM 10523 O HIS D 215 28.629 27.797 19.671 1.00 8.37 O

ATOM 10524 N GLY D 216 26.775 27.363 18.453 1.00 8.89 N

ATOM 10525 CA GLY D 216 25.913 28.257 19.213 1.00 9.33 C

ATOM 10526 C GLY D 216 24.477 28.165 18.747 1.00 9.62 C

ATOM 10527 O GLY D 216 24.178 27.465 17.776 1.00 9.31 O

ATOM 10528 N SER D 217 23.591 28.884 19.437 1.00 10.03 N

ATOM 10529 CA SER D 217 22.144 28.791 19.208 1.00 10.38 C

ATOM 10530 CB SER D 217 21.371 29.604 20.254 1.00 10.32 C

ATOM 10531 OG SER D 217 21.478 30.994 20.008 1.00 10.60 O

ATOM 10532 C SER D 217 21.717 29.185 17.791 1.00 10.66 C

ATOM 10533 O SER D 217 20.631 28.825 17.345 1.00 10.51 O

ATOM 10534 N TRP D 218 22.583 29.908 17.084 1.00 11.15 N

ATOM 10535 CA TRP D 218 22.337 30.254 15.685 1.00 11.74 C

ATOM 10536 CB TRP D 218 23.479 31.112 15.128 1.00 11.55 C

ATOM 10537 CG TRP D 218 24.862 30.525 15.314 1.00 11.21 C

ATOM 10538 CDl TRP D 218 25.486 29.613 14.508 1.00 11.48 C

ATOM 10539 NEl TRP D 218 26.744 29.326 15.001 1.00 11.58 N

ATOM 10540 CE2 TRP D 218 26.956 30.063 16.137 1.00 10.40 C

ATOM 10541 CD2 TRP D 218 25.792 30.833 16.366 1.00 10.98 C

ATOM 10542 CE3 TRP D 218 25.753 31.685 17.483 1.00 10.57 C

ATOM 10543 CZ3 TRP D 218 26.863 31.739 18.324 1.00 11.21 C

ATOM 10544 CH2 TRP D 218 28.010 30.966 18.065 1.00 10.59 C

ATOM 10545 CZ2 TRP D 218 28.075 30.124 16.980 1.00 11.42 C

ATOM 10546 C TRP D 218 22.131 29.013 14.810 1.00 12.24 C

ATOM 10547 O TRP D 218 21.446 29.080 13.785 1.00 12.14 O

ATOM 10548 N GLU D 219 22.721 27.892 15.229 1.00 12.70 N

ATOM 10549 CA GLU D 219 22.633 26.618 14.505 1.00 13.20 C

ATOM 10550 CB GLU D 219 23.672 25.637 15.032 1.00 13.61 C

ATOM 10551 CG GLU D 219 25.100 25.959 14.630 1.00 16.00 C

ATOM 10552 CD GLU D 219 26.093 25.031 15.291 1.00 18.65 C

ATOM 10553 OEl GLU D 219 25.912 24.732 16.492 1.00 20.16 O

ATOM 10554 OE2 GLU D 219 27.047 24.593 14.608 1.00 21.22 O

ATOM 10555 C GLU D 219 21.264 25.949 14.585 1.00 13.20 C

ATOM 10556 O GLU D 219 20.879 25.213 13.671 1.00 12.93 O

ATOM 10557 N GLY D 220 20.552 26.176 15.689 1.00 13.04 N

ATOM 10558 CA GLY D 220 19.250 25.541 15.910 1.00 13.23 C

ATOM 10559 C GLY D 220 19.317 24.229 16.676 1.00 13.11 C

ATOM 10560 O GLY D 220 18.289 23.581 16.902 1.00 12.89 O

ATOM 10561 N TYR D 221 20.529 23.846 17.078 1.00 13.08 N

ATOM 10562 CA TYR D 221 20.777 22.639 17.868 1.00 13.02 C

ATOM 10563 CB TYR D 221 21.224 21.471 16.977 1.00 14.10 C W2025-7029WO / AM102903-PCT

ATOM 10564 CG TYR D 221 20.285 21.129 15.845 1.00 15.69 C

ATOM 10565 CDl TYR D 221 20.455 21.696 14.577 1.00 16.75 C

ATOM 10566 CEl TYR D 221 19.589 21.384 13.526 1.00 17.81 C

ATOM 10567 CZ TYR D 221 18.546 20.490 13.739 1.00 17.21 C

ATOM 10568 OH TYR D 221 17.693 20.184 12.703 1.00 17.92 O

ATOM 10569 CE2 TYR D 221 18.358 19.908 14.987 1.00 17.15 C

ATOM 10570 CD2 TYR D 221 19.229 20.233 16.034 1.00 16.52 C

ATOM 10571 C TYR D 221 21.886 22.936 18.860 1.00 12.28 C

ATOM 10572 O TYR D 221 22.691 23.839 18.624 1.00 12.22 O

ATOM 10573 N THR D 222 21.953 22.164 19.947 1.00 11.29 N

ATOM 10574 CA THR D 222 23.053 22.296 20.906 1.00 10.49 C

ATOM 10575 CB THR D 222 22.855 21.441 22.184 1.00 10.36 C

ATOM 10576 OGl THR D 222 22.819 20.055 21.839 1.00 10.56 O

ATOM 10577 CG2 THR D 222 21.568 21.819 22.914 1.00 10.07 C

ATOM 10578 C THR D 222 24.388 21.925 20.259 1.00 10.13 C

ATOM 10579 O THR D 222 24.445 21.091 19.346 1.00 9.75 O

ATOM 10580 N GLY D 223 25.453 22.561 20.737 1.00 9.28 N

ATOM 10581 CA GLY D 223 26.792 22.314 20.237 1.00 8.75 C

ATOM 10582 C GLY D 223 27.794 23.034 21.106 1.00 8.73 C

ATOM 10583 O GLY D 223 27.435 23.952 21.850 1.00 8.42 O

ATOM 10584 N GLU D 224 29.054 22.626 20.995 1.00 8.38 N

ATOM 10585 CA GLU D 224 30.099 23.090 21.905 1.00 8.11 C

ATOM 10586 CB GLU D 224 31.114 21.968 22.161 1.00 8.16 C

ATOM 10587 CG GLU D 224 30.579 20.854 23.051 1.00 7.97 C

ATOM 10588 CD GLU D 224 30.504 21.246 24.521 1.00 7.95 C

ATOM 10589 OEl GLU D 224 30.779 22.419 24.857 1.00 7.66 O

ATOM 10590 OE2 GLU D 224 30.178 20.370 25.343 1.00 7.36 O

ATOM 10591 C GLU D 224 30.809 24.357 21.452 1.00 7.65 C

ATOM 10592 O GLU D 224 31.013 24.579 20.260 1.00 7.25 O

ATOM 10593 N ASN D 225 31.181 25.183 22.427 1.00 7.32 N

ATOM 10594 CA ASN D 225 31.872 26.449 22.183 1.00 6.93 C

ATOM 10595 CB ASN D 225 32.022 27.199 23.515 1.00 6.87 C

ATOM 10596 CG ASN D 225 32.536 28.623 23.356 1.00 5.87 C

ATOM 10597 ODl ASN D 225 32.346 29.266 22.324 1.00 3.87 O

ATOM 10598 ND2 ASN D 225 33.177 29.128 24.404 1.00 4.48 N

ATOM 10599 C ASN D 225 33.243 26.227 21.535 1.00 6.98 C

ATOM 10600 O ASN D 225 33.578 26.865 20.533 1.00 6.78 O

ATOM 10601 N SER D 226 34.011 25.300 22.106 1.00 6.87 N

ATOM 10602 CA SER D 226 35.378 25.013 21.666 1.00 6.78 C

ATOM 10603 CB SER D 226 36.372 25.887 22.451 1.00 6.50 C

ATOM 10604 OG SER D 226 37.691 25.765 21.952 1.00 6.92 O

ATOM 10605 C SER D 226 35.725 23.517 21.810 1.00 6.54 C

ATOM 10606 O SER D 226 36.588 23.152 22.609 1.00 6.56 O

ATOM 10607 N PRO D 227 35.062 22.646 21.020 1.00 6.59 N

ATOM 10608 CA PRO D 227 35.366 21.213 21.078 1.00 6.55 C

ATOM 10609 CB PRO D 227 34.274 20.587 20.201 1.00 6.41 C

ATOM 10610 CG PRO D 227 33.863 21.668 19.258 1.00 6.16 C

ATOM 10611 CD PRO D 227 34.015 22.954 20.024 1.00 6.57 C

ATOM 10612 C PRO D 227 36.748 20.916 20.492 1.00 6.81 C

ATOM 10613 O PRO D 227 37.118 21.501 19.468 1.00 6.82 O

ATOM 10614 N LEU D 228 37.506 20.034 21.143 1.00 6.98 N

ATOM 10615 CA LEU D 228 38.853 19.696 20.686 1.00 7.39 C

ATOM 10616 CB LEU D 228 39.626 18.900 21.754 1.00 7.36 C

ATOM 10617 CG LEU D 228 41.058 18.438 21.413 1.00 7.13 C

ATOM 10618 CDl LEU D 228 41.930 19.592 20.916 1.00 5.75 C

ATOM 10619 CD2 LEU D 228 41.718 17.750 22.606 1.00 7.16 C

ATOM 10620 C LEU D 228 38.788 18.913 19.371 1.00 7.84 C

ATOM 10621 O LEU D 228 39.567 19.163 18.453 1.00 7.15 O

ATOM 10622 N TYR D 229 37.847 17.975 19.299 1.00 8.56 N

ATOM 10623 CA TYR D 229 37.693 17.116 18.130 1.00 9.55 C

ATOM 10624 CB TYR D 229 37.989 15.660 18.493 1.00 9.46 C

ATOM 10625 CG TYR D 229 39.346 15.438 19.109 1.00 9.71 C

ATOM 10626 CDl TYR D 229 40.516 15.627 18.363 1.00 9.20 C W2025-7029WO / AM102903-PCT

ATOM 10627 CEl TYR D 229 41.766 15.416 18.929 1.00 9.74 C

ATOM 10628 CZ TYR D 229 41.853 15.009 20.250 1.00 9.62 C

ATOM 10629 OH TYR D 229 43.081 14.795 20.829 1.00 9.70 O

ATOM 10630 CE2 TYR D 229 40.706 14.806 21.005 1.00 9.68 C

ATOM 10631 CD2 TYR D 229 39.464 15.026 20.433 1.00 8.99 C

ATOM 10632 C TYR D 229 36.289 17.219 17.576 1.00 10.11 C

ATOM 10633 O TYR D 229 35.392 17.735 18.242 1.00 10.12 O

ATOM 10634 N LYS D 230 36.099 16.731 16.352 1.00 11.11 N

ATOM 10635 CA LYS D 230 34.766 16.652 15.771 1.00 12.21 C

ATOM 10636 CB LYS D 230 34.827 16.284 14.287 1.00 12.34 C

ATOM 10637 CG LYS D 230 35.201 14.829 13.987 1.00 13.79 C

ATOM 10638 CD LYS D 230 34.707 14.446 12.600 1.00 15.15 C

ATOM 10639 CE LYS D 230 35.410 13.229 12.060 1.00 17.28 C

ATOM 10640 NZ LYS D 230 34.966 12.971 10.656 1.00 19.27 N

ATOM 10641 C LYS D 230 33.912 15.641 16.536 1.00 12.67 C

ATOM 10642 O LYS D 230 34.436 14.774 17.241 1.00 12.45 O

ATOM 10643 N TYR D 231 32.598 15.780 16.412 1.00 13.45 N

ATOM 10644 CA TYR D 231 31.676 14.791 16.942 1.00 14.38 C

ATOM 10645 CB TYR D 231 30.281 15.410 17.106 1.00 14.61 C

ATOM 10646 CG TYR D 231 29.406 14.701 18.117 1.00 14.84 C

ATOM 10647 CDl TYR D 231 29.729 14.707 19.477 1.00 15.46 C

ATOM 10648 CEl TYR D 231 28.930 14.048 20.412 1.00 15.24 C

ATOM 10649 CZ TYR D 231 27.794 13.376 19.984 1.00 15.44 C

ATOM 10650 OH TYR D 231 27.001 12.731 20.898 1.00 15.11 O

ATOM 10651 CE2 TYR D 231 27.449 13.358 18.640 1.00 15.45 C

ATOM 10652 CD2 TYR D 231 28.256 14.020 17.714 1.00 15.50 C

ATOM 10653 C TYR D 231 31.685 13.604 15.960 1.00 15.06 C

ATOM 10654 O TYR D 231 31.896 13.812 14.758 1.00 14.81 O

ATOM 10655 N PRO D 232 31.498 12.357 16.460 1.00 15.87 N

ATOM 10656 CA PRO D 232 31.624 11.173 15.592 1.00 16.41 C

ATOM 10657 CB PRO D 232 31.183 10.026 16.506 1.00 16.46 C

ATOM 10658 CG PRO D 232 31.502 10.502 17.877 1.00 16.29 C

ATOM 10659 CD PRO D 232 31.180 11.965 17.847 1.00 15.76 C

ATOM 10660 C PRO D 232 30.758 11.209 14.328 1.00 17.09 C

ATOM 10661 O PRO D 232 31.139 10.638 13.304 1.00 17.35 O

ATOM 10662 N THR D 233 29.621 11.890 14.401 1.00 17.75 N

ATOM 10663 CA THR D 233 28.676 11.952 13.290 1.00 18.51 C

ATOM 10664 CB THR D 233 27.220 12.004 13.815 1.00 18.66 C

ATOM 10665 OGl THR D 233 27.082 13.085 14.745 1.00 19.52 O

ATOM 10666 CG2 THR D 233 26.850 10.696 14.512 1.00 18.79 C

ATOM 10667 C THR D 233 28.928 13.123 12.323 1.00 18.78 C

ATOM 10668 O THR D 233 28.209 13.275 11.332 1.00 18.74 O

ATOM 10669 N ASP D 234 29.941 13.942 12.614 1.00 19.02 N

ATOM 10670 CA ASP D 234 30.254 15.126 11.802 1.00 19.20 C

ATOM 10671 CB ASP D 234 31.262 16.038 12.514 1.00 19.22 C

ATOM 10672 CG ASP D 234 30.639 16.838 13.635 1.00 18.95 C

ATOM 10673 ODl ASP D 234 31.391 17.505 14.378 1.00 19.01 O

ATOM 10674 OD2 ASP D 234 29.399 16.803 13.778 1.00 19.03 O

ATOM 10675 C ASP D 234 30.781 14.773 10.421 1.00 19.46 C

ATOM 10676 O ASP D 234 31.713 13.977 10.284 1.00 19.64 O

ATOM 10677 N THR D 235 30.180 15.384 9.404 1.00 19.75 N

ATOM 10678 CA THR D 235 30.585 15.179 8.016 1.00 20.12 C

ATOM 10679 CB THR D 235 29.676 14.138 7.305 1.00 20.16 C

ATOM 10680 OGl THR D 235 30.142 13.930 5.966 1.00 21.63 O

ATOM 10681 CG2 THR D 235 28.217 14.600 7.272 1.00 20.08 C

ATOM 10682 C THR D 235 30.589 16.501 7.246 1.00 20.04 C

ATOM 10683 O THR D 235 29.924 17.461 7.642 1.00 20.34 O

ATOM 10684 N GLY D 236 31.338 16.544 6.147 1.00 20.03 N

ATOM 10685 CA GLY D 236 31.425 17.750 5.320 1.00 19.78 C

ATOM 10686 C GLY D 236 32.063 18.908 6.065 1.00 19.31 C

ATOM 10687 O GLY D 236 33.010 18.708 6.824 1.00 19.34 O

ATOM 10688 N SER D 237 31.531 20.115 5.861 1.00 18.92 N

ATOM 10689 CA SER D 237 32.055 21.317 6.517 1.00 18.40 C W2025-7029WO / AM102903-PCT

ATOM 10690 CB SER D 237 31.502 22.598 5.869 1.00 18.43 C

ATOM 10691 OG SER D 237 30.133 22.807 6.185 1.00 19.10 O

ATOM 10692 C SER D 237 31.821 21.331 8.037 1.00 17.86 C

ATOM 10693 O SER D 237 32.488 22.072 8.759 1.00 17.83 O

ATOM 10694 N ASN D 238 30.885 20.505 8.508 1.00 17.12 N

ATOM 10695 CA ASN D 238 30.614 20.363 9.941 1.00 16.46 C

ATOM 10696 CB ASN D 238 29.335 19.551 10.183 1.00 16.92 C

ATOM 10697 CG ASN D 238 28.073 20.317 9.812 1.00 18.54 C

ATOM 10698 ODl ASN D 238 28.017 21.548 9.915 1.00 20.50 O

ATOM 10699 ND2 ASN D 238 27.047 19.587 9.382 1.00 19.11 N

ATOM 10700 C ASN D 238 31.777 19.737 10.703 1.00 15.30 C

ATOM 10701 O ASN D 238 31.942 19.975 11.901 1.00 15.05 O

ATOM 10702 N ALA D 239 32.580 18.943 9.996 1.00 14.14 N

ATOM 10703 CA ALA D 239 33.756 18.296 10.574 1.00 12.86 C

ATOM 10704 CB ALA D 239 34.182 17.107 9.714 1.00 12.97 C

ATOM 10705 C ALA D 239 34.929 19.258 10.779 1.00 12.02 C

ATOM 10706 O ALA D 239 35.955 18.865 11.325 1.00 12.01 O

ATOM 10707 N TYR D 240 34.773 20.510 10.349 1.00 11.16 N

ATOM 10708 CA TYR D 240 35.839 21.522 10.463 1.00 10.51 C

ATOM 10709 CB TYR D 240 35.823 22.488 9.268 1.00 11.00 C

ATOM 10710 CG TYR D 240 35.849 21.875 7.878 1.00 12.28 C

ATOM 10711 CDl TYR D 240 36.296 20.572 7.658 1.00 12.79 C

ATOM 10712 CEl TYR D 240 36.323 20.028 6.368 1.00 13.96 C

ATOM 10713 CZ TYR D 240 35.919 20.802 5.292 1.00 13.06 C

ATOM 10714 OH TYR D 240 35.951 20.283 4.018 1.00 14.25 O

ATOM 10715 CE2 TYR D 240 35.491 22.101 5.484 1.00 13.18 C

ATOM 10716 CD2 TYR D 240 35.459 22.631 6.769 1.00 12.74 C

ATOM 10717 C TYR D 240 35.718 22.363 11.734 1.00 9.61 C

ATOM 10718 O TYR D 240 36.641 23.098 12.087 1.00 8.79 O

ATOM 10719 N LEU D 241 34.565 22.272 12.395 1.00 8.56 N

ATOM 10720 CA LEU D 241 34.245 23.151 13.516 1.00 8.07 C

ATOM 10721 CB LEU D 241 32.734 23.411 13.578 1.00 8.27 C

ATOM 10722 CG LEU D 241 32.138 24.216 12.411 1.00 8.19 C

ATOM 10723 CDl LEU D 241 30.619 24.043 12.339 1.00 9.18 C

ATOM 10724 CD2 LEU D 241 32.518 25.701 12.505 1.00 9.50 C

ATOM 10725 C LEU D 241 34.786 22.630 14.851 1.00 7.57 C

ATOM 10726 O LEU D 241 34.036 22.375 15.791 1.00 7.42 O

ATOM 10727 N ASN D 242 36.103 22.469 14.918 1.00 7.21 N

ATOM 10728 CA ASN D 242 36.768 22.001 16.133 1.00 7.24 C

ATOM 10729 CB ASN D 242 36.646 20.476 16.263 1.00 7.19 C

ATOM 10730 CG ASN D 242 37.235 19.747 15.082 1.00 6.97 C

ATOM 10731 ODl ASN D 242 38.437 19.503 15.033 1.00 8.00 O

ATOM 10732 ND2 ASN D 242 36.390 19.390 14.121 1.00 6.29 N

ATOM 10733 C ASN D 242 38.225 22.442 16.154 1.00 7.30 C

ATOM 10734 O ASN D 242 38.801 22.716 15.096 1.00 7.30 O

ATOM 10735 N VAL D 243 38.808 22.504 17.353 1.00 7.23 N

ATOM 10736 CA VAL D 243 40.168 23.017 17.548 1.00 7.31 C

ATOM 10737 CB VAL D 243 40.581 23.005 19.058 1.00 7.26 C

ATOM 10738 CGl VAL D 243 42.054 23.368 19.234 1.00 6.86 C

ATOM 10739 CG2 VAL D 243 39.705 23.963 19.876 1.00 7.08 C

ATOM 10740 C VAL D 243 41.194 22.248 16.698 1.00 7.73 C

ATOM 10741 O VAL D 243 42.027 22.862 16.027 1.00 7.45 O

ATOM 10742 N ASP D 244 41.115 20.915 16.736 1.00 7.93 N

ATOM 10743 CA ASP D 244 42.016 20.026 15.993 1.00 8.70 C

ATOM 10744 CB ASP D 244 41.574 18.559 16.164 1.00 9.23 C

ATOM 10745 CG ASP D 244 42.303 17.598 15.227 1.00 11.49 C

ATOM 10746 ODl ASP D 244 43.548 17.634 15.165 1.00 13.24 O

ATOM 10747 OD2 ASP D 244 41.617 16.784 14.566 1.00 14.56 O

ATOM 10748 C ASP D 244 42.102 20.393 14.510 1.00 8.65 C

ATOM 10749 O ASP D 244 43.194 20.653 13.989 1.00 8.73 O

ATOM 10750 N TYR D 245 40.953 20.427 13.837 1.00 8.33 N

ATOM 10751 CA TYR D 245 40.935 20.739 12.417 1.00 8.19 C

ATOM 10752 CB TYR D 245 39.532 20.590 11.815 1.00 8.59 C W2025-7029WO / AM102903-PCT

ATOM 10753 CG TYR D 245 39.567 20.605 10.306 1.00 9.28 C

ATOM 10754 CDl TYR D 245 39.721 19.422 9.586 1.00 10.36 C

ATOM 10755 CEl TYR D 245 39.779 19.431 8.193 1.00 10.59 C

ATOM 10756 CZ TYR D 245 39.694 20.633 7.517 1.00 10.26 C

ATOM 10757 OH TYR D 245 39.748 20.645 6.145 1.00 10.77 O

ATOM 10758 CE2 TYR D 245 39.542 21.823 8.210 1.00 10.84 C

ATOM 10759 CD2 TYR D 245 39.483 21.805 9.597 1.00 9.32 C

ATOM 10760 C TYR D 245 41.497 22.131 12.127 1.00 7.79 C

ATOM 10761 O TYR D 245 42.336 22.296 11.231 1.00 7.42 O

ATOM 10762 N VAL D 246 41.047 23.119 12.899 1.00 7.42 N

ATOM 10763 CA VAL D 246 41.400 24.524 12.659 1.00 7.08 C

ATOM 10764 CB VAL D 246 40.581 25.493 13.552 1.00 7.27 C

ATOM 10765 CGl VAL D 246 41.051 26.937 13.367 1.00 6.58 C

ATOM 10766 CG2 VAL D 246 39.093 25.380 13.227 1.00 6.90 C

ATOM 10767 C VAL D 246 42.901 24.791 12.789 1.00 7.04 C

ATOM 10768 O VAL D 246 43.502 25.382 11.883 1.00 6.93 O

ATOM 10769 N MET D 247 43.500 24.350 13.900 1.00 6.88 N

ATOM 10770 CA MET D 247 44.934 24.573 14.147 1.00 6.62 C

ATOM 10771 CB MET D 247 45.335 24.113 15.556 1.00 7.00 C

ATOM 10772 CG MET D 247 44.672 24.871 16.713 1.00 6.18 C

ATOM 10773 SD MET D 247 44.791 26.672 16.648 1.00 6.06

ATOM 10774 CE MET D 247 46.566 26.922 16.553 1.00 4.08 C

ATOM 10775 C MET D 247 45.804 23.877 13.100 1.00 6.76 C

ATOM 10776 O MET D 247 46.821 24.427 12.647 1.00 6.49 O

ATOM 10777 N ASN D 248 45.391 22.672 12.718 1.00 6.71 N

ATOM 10778 CA ASN D 248 46.078 21.904 11.678 1.00 6.89 C

ATOM 10779 CB ASN D 248 45.648 20.435 11.711 1.00 6.75 C

ATOM 10780 CG ASN D 248 46.428 19.625 12.725 1.00 6.56 C

ATOM 10781 ODl ASN D 248 47.648 19.471 12.608 1.00 5.80 O

ATOM 10782 ND2 ASN D 248 45.730 19.098 13.730 1.00 6.61 N

ATOM 10783 C ASN D 248 45.902 22.494 10.278 1.00 7.03 C

ATOM 10784 O ASN D 248 46.820 22.439 9.459 1.00 6.86 O

ATOM 10785 N TYR D 249 44.734 23.062 10.001 1.00 7.14 N

ATOM 10786 CA TYR D 249 44.533 23.767 8.731 1.00 7.44 C

ATOM 10787 CB TYR D 249 43.093 24.271 8.579 1.00 7.68 C

ATOM 10788 CG TYR D 249 42.837 24.874 7.214 1.00 8.45 C

ATOM 10789 CDl TYR D 249 42.308 24.104 6.183 1.00 8.64 C

ATOM 10790 CEl TYR D 249 42.082 24.645 4.928 1.00 8.66 C

ATOM 10791 CZ TYR D 249 42.394 25.970 4.688 1.00 8.71 C

ATOM 10792 OH TYR D 249 42.173 26.501 3.441 1.00 9.19 O

ATOM 10793 CE2 TYR D 249 42.931 26.760 5.691 1.00 9.06 C

ATOM 10794 CD2 TYR D 249 43.147 26.210 6.947 1.00 9.06 C

ATOM 10795 C TYR D 249 45.526 24.927 8.573 1.00 7.24 C

ATOM 10796 O TYR D 249 46.170 25.060 7.526 1.00 7.15 O

ATOM 10797 N TRP D 250 45.630 25.762 9.609 1.00 7.03 N

ATOM 10798 CA TRP D 250 46.591 26.874 9.639 1.00 6.88 C

ATOM 10799 CB TRP D 250 46.493 27.650 10.961 1.00 6.48 C

ATOM 10800 CG TRP D 250 45.473 28.754 10.895 1.00 6.37 C

ATOM 10801 CDl TRP D 250 44.158 28.680 11.259 1.00 5.81 C

ATOM 10802 NEl TRP D 250 43.536 29.885 11.039 1.00 6.00 N

ATOM 10803 CE2 TRP D 250 44.443 30.764 10.505 1.00 5.70 C

ATOM 10804 CD2 TRP D 250 45.681 30.084 10.402 1.00 5.75 C

ATOM 10805 CE3 TRP D 250 46.797 30.772 9.891 1.00 5.72 C

ATOM 10806 CZ3 TRP D 250 46.639 32.109 9.502 1.00 5.72 C

ATOM 10807 CH2 TRP D 250 45.387 32.756 9.617 1.00 5.82 C

ATOM 10808 CZ2 TRP D 250 44.283 32.098 10.113 1.00 5.69 C

ATOM 10809 C TRP D 250 48.025 26.396 9.399 1.00 7.23 C

ATOM 10810 O TRP D 250 48.749 26.970 8.581 1.00 7.09 O

ATOM 10811 N LYS D 251 48.409 25.333 10.104 1.00 7.40 N

ATOM 10812 CA LYS D 251 49.740 24.733 9.988 1.00 7.94 C

ATOM 10813 CB LYS D 251 49.898 23.656 11.065 1.00 8.24 C

ATOM 10814 CG LYS D 251 51.269 23.008 11.157 1.00 9.58 C

ATOM 10815 CD LYS D 251 51.188 21.735 11.979 1.00 10.03 C W2025-7029WO / AM102903-PCT

ATOM 10816 CE LYS D 251 52.568 21.164 12.265 1.00 13.08 C

ATOM 10817 NZ LYS D 251 52.489 19.784 12.838 1.00 14.19 N

ATOM 10818 C LYS D 251 49.988 24.155 8.585 1.00 7.57 C

ATOM 10819 O LYS D 251 51.029 24.413 7.975 1.00 7.64 O

ATOM 10820 N ASP D 252 49.023 23.392 8.079 1.00 7.25 N

ATOM 10821 CA ASP D 252 49.145 22.732 6.777 1.00 7.19 C

ATOM 10822 CB ASP D 252 48.060 21.665 6.603 1.00 7.31 C

ATOM 10823 CG ASP D 252 48.191 20.526 7.599 1.00 7.34 C

ATOM 10824 ODl ASP D 252 49.202 20.462 8.325 1.00 7.58 O

ATOM 10825 OD2 ASP D 252 47.268 19.694 7.658 1.00 9.18 O

ATOM 10826 C ASP D 252 49.114 23.696 5.591 1.00 7.00 C

ATOM 10827 O ASP D 252 49.463 23.314 4.470 1.00 6.44 O

ATOM 10828 N ASN D 253 48.688 24.934 5.838 1.00 6.79 N

ATOM 10829 CA ASN D 253 48.665 25.948 4.791 1.00 7.01 C

ATOM 10830 CB ASN D 253 47.239 26.479 4.565 1.00 6.99 C

ATOM 10831 CG ASN D 253 46.317 25.430 3.967 1.00 7.92 C

ATOM 10832 ODl ASN D 253 46.075 25.412 2.755 1.00 8.75 O

ATOM 10833 ND2 ASN D 253 45.806 24.542 4.812 1.00 7.49 N

ATOM 10834 C ASN D 253 49.674 27.082 4.983 1.00 6.73 C

ATOM 10835 O ASN D 253 49.535 28.144 4.377 1.00 6.60 O

ATOM 10836 N GLY D 254 50.690 26.855 5.819 1.00 6.93 N

ATOM 10837 CA GLY D 254 51.851 27.744 5.847 1.00 6.99 C

ATOM 10838 C GLY D 254 52.320 28.324 7.170 1.00 7.27 C

ATOM 10839 O GLY D 254 53.433 28.844 7.246 1.00 7.37 O

ATOM 10840 N ALA D 255 51.491 28.246 8.211 1.00 7.36 N

ATOM 10841 CA ALA D 255 51.840 28.834 9.510 1.00 7.54 C

ATOM 10842 CB ALA D 255 50.589 29.150 10.316 1.00 7.38 C

ATOM 10843 C ALA D 255 52.769 27.932 10.317 1.00 7.82 C

ATOM 10844 O ALA D 255 52.424 26.776 10.571 1.00 7.43 O

ATOM 10845 N PRO D 256 53.938 28.462 10.743 1.00 8.20 N

ATOM 10846 CA PRO D 256 54.849 27.690 11.589 1.00 8.26 C

ATOM 10847 CB PRO D 256 56.037 28.645 11.802 1.00 8.26 C

ATOM 10848 CG PRO D 256 55.935 29.651 10.716 1.00 8.23 C

ATOM 10849 CD PRO D 256 54.458 29.819 10.492 1.00 8.34 C

ATOM 10850 C PRO D 256 54.184 27.376 12.924 1.00 8.61 C

ATOM 10851 O PRO D 256 53.543 28.254 13.519 1.00 8.66 O

ATOM 10852 N ALA D 257 54.332 26.133 13.381 1.00 8.88 N

ATOM 10853 CA ALA D 257 53.711 25.668 14.620 1.00 9.13 C

ATOM 10854 CB ALA D 257 54.078 24.212 14.888 1.00 9.25 C

ATOM 10855 C ALA D 257 54.067 26.553 15.821 1.00 9.34 C

ATOM 10856 O ALA D 257 53.180 26.938 16.581 1.00 9.33 O

ATOM 10857 N GLU D 258 55.352 26.895 15.959 1.00 9.24 N

ATOM 10858 CA GLU D 258 55.853 27.735 17.062 1.00 9.73 C

ATOM 10859 CB GLU D 258 57.373 27.966 16.927 1.00 9.77 C

ATOM 10860 CG GLU D 258 57.766 28.803 15.704 1.00 11.07 C

ATOM 10861 CD GLU D 258 59.260 29.105 15.577 1.00 12.10 C

ATOM 10862 OEl GLU D 258 60.078 28.549 16.347 1.00 13.42 O

ATOM 10863 OE2 GLU D 258 59.604 29.922 14.679 1.00 16.02 O

ATOM 10864 C GLU D 258 55.130 29.084 17.178 1.00 8.89 C

ATOM 10865 O GLU D 258 55.062 29.667 18.262 1.00 8.94 O

ATOM 10866 N LYS D 259 54.599 29.571 16.058 1.00 8.17 N

ATOM 10867 CA LYS D 259 53.916 30.861 16.008 1.00 7.74 C

ATOM 10868 CB LYS D 259 54.200 31.563 14.682 1.00 7.86 C

ATOM 10869 CG LYS D 259 55.531 32.310 14.641 1.00 7.68 C

ATOM 10870 CD LYS D 259 55.651 33.098 13.343 1.00 7.11 C

ATOM 10871 CE LYS D 259 56.970 33.860 13.269 1.00 5.96 C

ATOM 10872 NZ LYS D 259 57.029 34.714 12.037 1.00 2.92 N

ATOM 10873 C LYS D 259 52.404 30.763 16.223 1.00 7.40 C

ATOM 10874 O LYS D 259 51.744 31.777 16.478 1.00 7.62 O

ATOM 10875 N LEU D 260 51.863 29.553 16.114 1.00 6.67 N

ATOM 10876 CA LEU D 260 50.433 29.334 16.292 1.00 6.33 C

ATOM 10877 CB LEU D 260 49.980 28.072 15.549 1.00 6.27 C

ATOM 10878 CG LEU D 260 49.847 28.169 14.027 1.00 6.07 C W2025-7029WO / AM102903-PCT

ATOM 10879 CDl LEU D 260 49.703 26.778 13.424 1.00 6.34 C

ATOM 10880 CD2 LEU D 260 48.651 29.054 13.636 1.00 6.84 C

ATOM 10881 C LEU D 260 50.061 29.245 17.766 1.00 6.18 C

ATOM 10882 O LEU D 260 50.652 28.474 18.522 1.00 5.94 O

ATOM 10883 N ILE D 261 49.075 30.046 18.157 1.00 6.16 N

ATOM 10884 CA ILE D 261 48.616 30.125 19.540 1.00 6.20 C

ATOM 10885 CB ILE D 261 48.790 31.574 20.107 1.00 6.20 C

ATOM 10886 CGl ILE D 261 50.234 32.071 19.940 1.00 6.08 C

ATOM 10887 CDl ILE D 261 51.320 31.198 20.616 1.00 4.78 C

ATOM 10888 CG2 ILE D 261 48.361 31.661 21.563 1.00 6.49 C

ATOM 10889 C ILE D 261 47.147 29.682 19.582 1.00 6.12 C

ATOM 10890 O ILE D 261 46.299 30.255 18.894 1.00 6.05 O

ATOM 10891 N VAL D 262 46.863 28.658 20.382 1.00 6.27 N

ATOM 10892 CA VAL D 262 45.525 28.048 20.436 1.00 6.43 C

ATOM 10893 CB VAL D 262 45.588 26.582 20.955 1.00 6.54 C

ATOM 10894 CGl VAL D 262 44.213 25.902 20.876 1.00 6.18 C

ATOM 10895 CG2 VAL D 262 46.630 25.785 20.183 1.00 6.10 C

ATOM 10896 C VAL D 262 44.590 28.870 21.322 1.00 6.36 C

ATOM 10897 O VAL D 262 44.966 29.246 22.425 1.00 6.33 O

ATOM 10898 N GLY D 263 43.374 29.135 20.839 1.00 6.42 N

ATOM 10899 CA GLY D 263 42.402 29.952 21.581 1.00 6.29 C

ATOM 10900 C GLY D 263 41.576 29.188 22.606 1.00 6.18 C

ATOM 10901 O GLY D 263 40.943 28.180 22.279 1.00 6.40 O

ATOM 10902 N PHE D 264 41.577 29.682 23.843 1.00 6.06 N

ATOM 10903 CA PHE D 264 40.878 29.049 24.964 1.00 5.72 C

ATOM 10904 CB PHE D 264 41.853 28.724 26.102 1.00 6.14 C

ATOM 10905 CG PHE D 264 42.688 27.492 25.880 1.00 7.11 C

ATOM 10906 CDl PHE D 264 43.675 27.459 24.894 1.00 7.39 C

ATOM 10907 CEl PHE D 264 44.455 26.321 24.707 1.00 7.78 C

ATOM 10908 CZ PHE D 264 44.263 25.213 25.522 1.00 7.15 C

ATOM 10909 CE2 PHE D 264 43.289 25.242 26.514 1.00 6.71 C

ATOM 10910 CD2 PHE D 264 42.514 26.371 26.691 1.00 7.01 C

ATOM 10911 C PHE D 264 39.806 29.986 25.506 1.00 5.19 C

ATOM 10912 O PHE D 264 40.108 31.120 25.890 1.00 5.25 O

ATOM 10913 N PRO D 265 38.547 29.526 25.532 1.00 4.77 N

ATOM 10914 CA PRO D 265 37.472 30.376 26.029 1.00 4.38 C

ATOM 10915 CB PRO D 265 36.303 29.981 25.125 1.00 4.04 C

ATOM 10916 CG PRO D 265 36.562 28.515 24.791 1.00 4.38 C

ATOM 10917 CD PRO D 265 38.031 28.233 25.034 1.00 4.74 C

ATOM 10918 C PRO D 265 37.118 30.143 27.502 1.00 4.17 C

ATOM 10919 O PRO D 265 36.880 29.007 27.906 1.00 4.69 O

ATOM 10920 N THR D 266 37.071 31.217 28.290 1.00 3.96 N

ATOM 10921 CA THR D 266 36.655 31.131 29.696 1.00 3.72 C

ATOM 10922 CB THR D 266 37.530 32.007 30.616 1.00 3.63 C

ATOM 10923 OGl THR D 266 37.584 33.337 30.094 1.00 3.74 O

ATOM 10924 CG2 THR D 266 38.944 31.427 30.736 1.00 2.51 C

ATOM 10925 C THR D 266 35.171 31.477 29.889 1.00 3.84 C

ATOM 10926 O THR D 266 34.778 32.069 30.900 1.00 3.48 O

ATOM 10927 N TYR D 267 34.364 31.070 28.913 1.00 4.09 N

ATOM 10928 CA TYR D 267 32.927 31.314 28.875 1.00 4.74 C

ATOM 10929 CB TYR D 267 32.635 32.692 28.254 1.00 4.77 C

ATOM 10930 CG TYR D 267 33.007 32.746 26.791 1.00 5.10 C

ATOM 10931 CDl TYR D 267 32.056 32.480 25.800 1.00 4.27 C

ATOM 10932 CEl TYR D 267 32.405 32.485 24.461 1.00 4.54 C

ATOM 10933 CZ TYR D 267 33.720 32.752 24.100 1.00 4.66 C

ATOM 10934 OH TYR D 267 34.070 32.761 22.775 1.00 5.16 O

ATOM 10935 CE2 TYR D 267 34.684 33.005 25.060 1.00 4.45 C

ATOM 10936 CD2 TYR D 267 34.328 33.000 26.395 1.00 4.07 C

ATOM 10937 C TYR D 267 32.297 30.217 28.016 1.00 5.12 C

ATOM 10938 O TYR D 267 33.009 29.477 27.324 1.00 5.02 O

ATOM 10939 N GLY D 268 30.969 30.123 28.044 1.00 5.31 N

ATOM 10940 CA GLY D 268 30.249 29.189 27.190 1.00 5.77 C

ATOM 10941 C GLY D 268 29.076 29.808 26.445 1.00 6.17 C W2025-7029WO / AM102903-PCT

ATOM 10942 O GLY D 268 28.668 30.932 26.729 1.00 6.25 O

ATOM 10943 N HIS D 269 28.546 29.076 25.472 1.00 6.47 N

ATOM 10944 CA HIS D 269 27.312 29.475 24.812 1.00 6.86 C

ATOM 10945 CB HIS D 269 27.404 29.266 23.299 1.00 6.82 C

ATOM 10946 CG HIS D 269 28.232 30.299 22.604 1.00 7.19 C

ATOM 10947 NDl HIS D 269 27.714 31.502 22.173 1.00 6.59 N

ATOM 10948 CEl HIS D 269 28.673 32.215 21.610 1.00 5.96 C

ATOM 10949 NE2 HIS D 269 29.794 31.519 21.663 1.00 7.03 N

ATOM 10950 CD2 HIS D 269 29.547 30.319 22.283 1.00 6.64 C

ATOM 10951 C HIS D 269 26.160 28.678 25.411 1.00 7.01 C

ATOM 10952 O HIS D 269 26.282 27.474 25.629 1.00 7.00 O

ATOM 10953 N ASN D 270 25.056 29.359 25.704 1.00 7.55 N

ATOM 10954 CA ASN D 270 23.870 28.682 26.228 1.00 7.84 C

ATOM 10955 CB ASN D 270 23.488 29.189 27.634 1.00 7.72 C

ATOM 10956 CG ASN D 270 23.104 30.663 27.661 1.00 8.26 C

ATOM 10957 ODl ASN D 270 22.759 31.245 26.646 1.00 8.73 O

ATOM 10958 ND2 ASN D 270 23.148 31.265 28.842 1.00 8.50 N

ATOM 10959 C ASN D 270 22.684 28.686 25.248 1.00 8.20 C

ATOM 10960 O ASN D 270 22.677 29.435 24.258 1.00 7.59 O

ATOM 10961 N PHE D 271 21.697 27.832 25.538 1.00 8.45 N

ATOM 10962 CA PHE D 271 20.629 27.494 24.601 1.00 9.00 C

ATOM 10963 CB PHE D 271 20.927 26.144 23.925 1.00 9.05 C

ATOM 10964 CG PHE D 271 22.214 26.095 23.145 1.00 9.33 C

ATOM 10965 CDl PHE D 271 23.444 26.015 23.797 1.00 8.48 C

ATOM 10966 CEl PHE D 271 24.635 25.955 23.075 1.00 8.89 C

ATOM 10967 CZ PHE D 271 24.599 25.943 21.681 1.00 8.93 C

ATOM 10968 CE2 PHE D 271 23.375 25.996 21.019 1.00 9.57 C

ATOM 10969 CD2 PHE D 271 22.190 26.069 21.751 1.00 8.44 C

ATOM 10970 C PHE D 271 19.303 27.316 25.331 1.00 9.24 C

ATOM 10971 O PHE D 271 19.280 26.950 26.505 1.00 8.96 O

ATOM 10972 N ILE D 272 18.201 27.553 24.624 1.00 9.80 N

ATOM 10973 CA ILE D 272 16.891 27.092 25.087 1.00 10.33 C

ATOM 10974 CB ILE D 272 15.761 28.146 24.868 1.00 10.31 C

ATOM 10975 CGl ILE D 272 16.047 29.448 25.639 1.00 10.18 C

ATOM 10976 CDl ILE D 272 16.342 29.274 27.139 1.00 10.04 C

ATOM 10977 CG2 ILE D 272 14.385 27.568 25.262 1.00 10.42 C

ATOM 10978 C ILE D 272 16.548 25.795 24.359 1.00 10.65 C

ATOM 10979 O ILE D 272 16.403 25.793 23.137 1.00 11.15 O

ATOM 10980 N LEU D 273 16.428 24.703 25.112 1.00 11.02 N

ATOM 10981 CA LEU D 273 16.076 23.396 24.556 1.00 11.61 C

ATOM 10982 CB LEU D 273 16.317 22.286 25.591 1.00 11.30 C

ATOM 10983 CG LEU D 273 17.731 21.996 26.104 1.00 11.49 C

ATOM 10984 CDl LEU D 273 17.675 21.012 27.273 1.00 10.18 C

ATOM 10985 CD2 LEU D 273 18.641 21.470 24.999 1.00 10.35 C

ATOM 10986 C LEU D 273 14.612 23.356 24.117 1.00 12.42 C

ATOM 10987 O LEU D 273 13.722 23.760 24.872 1.00 12.18 O

ATOM 10988 N SER D 274 14.370 22.872 22.901 1.00 13.24 N

ATOM 10989 CA SER D 274 13.007 22.708 22.381 1.00 14.52 C

ATOM 10990 CB SER D 274 13.035 22.342 20.897 1.00 14.48 C

ATOM 10991 OG SER D 274 13.695 23.338 20.138 1.00 14.70 O

ATOM 10992 C SER D 274 12.214 21.657 23.163 1.00 15.18 C

ATOM 10993 O SER D 274 10.988 21.752 23.277 1.00 15.51 O

ATOM 10994 N ASN D 275 12.924 20.664 23.697 1.00 15.98 N

ATOM 10995 CA ASN D 275 12.332 19.627 24.539 1.00 16.95 C

ATOM 10996 CB ASN D 275 11.989 18.385 23.699 1.00 17.24 C

ATOM 10997 CG ASN D 275 11.122 17.370 24.450 1.00 18.52 C

ATOM 10998 ODl ASN D 275 10.795 17.545 25.630 1.00 20.62 O

ATOM 10999 ND2 ASN D 275 10.749 16.297 23.760 1.00 19.80 N

ATOM 11000 C ASN D 275 13.292 19.273 25.679 1.00 16.97 C

ATOM 11001 O ASN D 275 14.354 18.707 25.436 1.00 17.20 O

ATOM 11002 N PRO D 276 12.933 19.618 26.930 1.00 17.30 N

ATOM 11003 CA PRO D 276 13.822 19.330 28.068 1.00 17.39 C

ATOM 11004 CB PRO D 276 12.986 19.729 29.295 1.00 17.42 C W2025-7029WO / AM102903-PCT

ATOM 11005 CG PRO D 276 11.594 19.955 28.789 1.00 17.74 C

ATOM 11006 CD PRO D 276 11.711 20.323 27.351 1.00 17.17 C

ATOM 11007 C PRO D 276 14.277 17.865 28.171 1.00 17.49 C

ATOM 11008 O PRO D 276 15.252 17.576 28.868 1.00 17.42 O

ATOM 11009 N SER D 277 13.583 16.964 27.475 1.00 17.64 N

ATOM 11010 CA SER D 277 13.921 15.536 27.478 1.00 17.80 C

ATOM 11011 CB SER D 277 12.700 14.688 27.109 1.00 18.02 C

ATOM 11012 OG SER D 277 12.316 14.907 25.759 1.00 19.15 O

ATOM 11013 C SER D 277 15.108 15.190 26.570 1.00 17.57 C

ATOM 11014 O SER D 277 15.824 14.228 26.843 1.00 17.64 O

ATOM 11015 N ASN D 278 15.306 15.963 25.497 1.00 17.19 N

ATOM 11016 CA ASN D 278 16.472 15.796 24.615 1.00 17.08 C

ATOM 11017 CB ASN D 278 16.090 15.990 23.139 1.00 17.45 C

ATOM 11018 CG ASN D 278 17.157 15.460 22.173 1.00 18.98 C

ATOM 11019 ODl ASN D 278 18.279 15.115 22.574 1.00 21.15 O

ATOM 11020 ND2 ASN D 278 16.805 15.389 20.891 1.00 20.55 N

ATOM 11021 C ASN D 278 17.593 16.757 25.009 1.00 16.44 C

ATOM 11022 O ASN D 278 17.473 17.969 24.819 1.00 16.43 O

ATOM 11023 N THR D 279 18.677 16.206 25.553 1.00 15.79 N

ATOM 11024 CA THR D 279 19.717 17.008 26.206 1.00 15.25 C

ATOM 11025 CB THR D 279 19.689 16.809 27.740 1.00 15.21 C

ATOM 11026 OGl THR D 279 19.925 15.431 28.055 1.00 15.27 O

ATOM 11027 CG2 THR D 279 18.345 17.242 28.322 1.00 14.92 C

ATOM 11028 C THR D 279 21.143 16.739 25.717 1.00 14.96 C

ATOM 11029 O THR D 279 22.102 17.316 26.239 1.00 14.98 O

ATOM 11030 N GLY D 280 21.289 15.868 24.723 1.00 14.36 N

ATOM 11031 CA GLY D 280 22.613 15.529 24.210 1.00 13.69 C

ATOM 11032 C GLY D 280 23.136 16.574 23.243 1.00 13.31 C

ATOM 11033 O GLY D 280 22.550 17.649 23.092 1.00 13.33 O

ATOM 11034 N ILE D 281 24.251 16.255 22.597 1.00 12.79 N

ATOM 11035 CA ILE D 281 24.803 17.086 21.531 1.00 12.39 C

ATOM 11036 CB ILE D 281 26.270 16.687 21.211 1.00 12.10 C

ATOM 11037 CGl ILE D 281 27.191 16.919 22.424 1.00 12.33 C

ATOM 11038 CDl ILE D 281 27.421 18.380 22.826 1.00 11.36 C

ATOM 11039 CG2 ILE D 281 26.779 17.383 19.941 1.00 12.04 C

ATOM 11040 C ILE D 281 23.929 16.931 20.288 1.00 12.32 C

ATOM 11041 O ILE D 281 23.583 15.811 19.895 1.00 12.17 O

ATOM 11042 N GLY D 282 23.566 18.059 19.687 1.00 12.15 N

ATOM 11043 CA GLY D 282 22.738 18.065 18.485 1.00 12.69 C

ATOM 11044 C GLY D 282 21.250 18.062 18.784 1.00 12.88 C

ATOM 11045 O GLY D 282 20.435 17.832 17.888 1.00 13.10 O

ATOM 11046 N ALA D 283 20.898 18.306 20.046 1.00 12.98 N

ATOM 11047 CA ALA D 283 19.494 18.393 20.462 1.00 13.09 C

ATOM 11048 CB ALA D 283 19.383 18.316 21.983 1.00 12.88 C

ATOM 11049 C ALA D 283 18.882 19.696 19.939 1.00 13.06 C

ATOM 11050 O ALA D 283 19.551 20.727 19.950 1.00 13.04 O

ATOM 11051 N PRO D 284 17.618 19.651 19.466 1.00 12.95 N

ATOM 11052 CA PRO D 284 16.960 20.849 18.940 1.00 12.83 C

ATOM 11053 CB PRO D 284 15.580 20.335 18.505 1.00 12.92 C

ATOM 11054 CG PRO D 284 15.769 18.885 18.296 1.00 13.54 C

ATOM 11055 CD PRO D 284 16.735 18.477 19.369 1.00 13.13 C

ATOM 11056 C PRO D 284 16.806 21.958 19.978 1.00 12.25 C

ATOM 11057 O PRO D 284 16.466 21.699 21.136 1.00 12.05 O

ATOM 11058 N THR D 285 17.068 23.185 19.540 1.00 12.02 N

ATOM 11059 CA THR D 285 16.957 24.371 20.378 1.00 11.54 C

ATOM 11060 CB THR D 285 18.344 24.986 20.669 1.00 11.43 C

ATOM 11061 OGl THR D 285 19.020 25.259 19.435 1.00 11.02 O

ATOM 11062 CG2 THR D 285 19.173 24.033 21.494 1.00 10.56 C

ATOM 11063 C THR D 285 16.075 25.397 19.683 1.00 11.53 C

ATOM 11064 O THR D 285 15.891 25.342 18.464 1.00 11.62 O

ATOM 11065 N SER D 286 15.527 26.327 20.457 1.00 11.49 N

ATOM 11066 CA SER D 286 14.561 27.287 19.926 1.00 11.52 C

ATOM 11067 CB SER D 286 13.218 27.146 20.652 1.00 11.77 C W2025-7029WO / AM102903-PCT

ATOM 11068 OG SER D 286 13.392 27.278 22.049 1.00 12.15 O

ATOM 11069 C SER D 286 15.054 28.731 19.994 1.00 11.38 C

ATOM 11070 O SER D 286 14.340 29.659 19.589 1.00 11.61 O

ATOM 11071 N GLY D 287 16.270 28.912 20.504 1.00 10.82 N

ATOM 11072 CA GLY D 287 16.869 30.242 20.629 1.00 10.23 C

ATOM 11073 C GLY D 287 18.007 30.274 21.628 1.00 9.67 C

ATOM 11074 O GLY D 287 18.369 29.243 22.207 1.00 9.49 O

ATOM 11075 N ALA D 288 18.571 31.464 21.821 1.00 9.41 N

ATOM 11076 CA ALA D 288 19.658 31.684 22.776 1.00 9.24 C

ATOM 11077 CB ALA D 288 20.298 33.044 22.536 1.00 9.19 C

ATOM 11078 C ALA D 288 19.181 31.580 24.219 1.00 9.20 C

ATOM 11079 O ALA D 288 18.051 31.951 24.540 1.00 9.04 O

ATOM 11080 N GLY D 289 20.051 31.073 25.087 1.00 8.95 N

ATOM 11081 CA GLY D 289 19.769 31.039 26.512 1.00 8.71 C

ATOM 11082 C GLY D 289 19.905 32.425 27.119 1.00 8.74 C

ATOM 11083 O GLY D 289 20.296 33.371 26.427 1.00 8.73 O

ATOM 11084 N PRO D 290 19.582 32.551 28.419 1.00 8.53 N

ATOM 11085 CA PRO D 290 19.550 33.837 29.121 1.00 8.60 C

ATOM 11086 CB PRO D 290 18.839 33.495 30.431 1.00 8.30 C

ATOM 11087 CG PRO D 290 19.169 32.042 30.659 1.00 8.40 C

ATOM 11088 CD PRO D 290 19.196 31.425 29.298 1.00 8.38 C

ATOM 11089 C PRO D 290 20.931 34.431 29.417 1.00 8.77 C

ATOM 11090 O PRO D 290 21.893 33.698 29.649 1.00 8.73 O

ATOM 11091 N ALA D 291 21.004 35.761 29.402 1.00 9.14 N

ATOM 11092 CA ALA D 291 22.189 36.483 29.838 1.00 9.21 C

ATOM 11093 CB ALA D 291 22.068 37.960 29.476 1.00 9.38 C

ATOM 11094 C ALA D 291 22.345 36.318 31.343 1.00 9.18 C

ATOM 11095 O ALA D 291 21.353 36.245 32.072 1.00 9.45 O

ATOM 11096 N GLY D 292 23.591 36.241 31.801 1.00 9.19 N

ATOM 11097 CA GLY D 292 23.888 36.192 33.223 1.00 9.15 C

ATOM 11098 C GLY D 292 23.753 37.566 33.865 1.00 9.13 C

ATOM 11099 O GLY D 292 23.723 38.582 33.166 1.00 9.07 O

ATOM 11100 N PRO D 293 23.674 37.615 35.202 1.00 9.34 N

ATOM 11101 CA PRO D 293 23.511 38.933 35.818 1.00 9.83 C

ATOM 11102 CB PRO D 293 23.024 38.617 37.240 1.00 9.77 C

ATOM 11103 CG PRO D 293 23.380 37.185 37.492 1.00 9.62 C

ATOM 11104 CD PRO D 293 23.750 36.524 36.191 1.00 9.51 C

ATOM 11105 C PRO D 293 24.802 39.778 35.822 1.00 10.16 C

ATOM 11106 O PRO D 293 24.735 40.995 36.006 1.00 10.18 O

ATOM 11107 N TYR D 294 25.951 39.148 35.582 1.00 10.36 N

ATOM 11108 CA TYR D 294 27.241 39.841 35.697 1.00 10.84 C

ATOM 11109 CB TYR D 294 28.221 39.016 36.541 1.00 10.97 C

ATOM 11110 CG TYR D 294 27.737 38.824 37.965 1.00 11.35 C

ATOM 11111 CDl TYR D 294 27.269 37.587 38.405 1.00 11.18 C

ATOM 11112 CEl TYR D 294 26.817 37.412 39.713 1.00 11.41 C

ATOM 11113 CZ TYR D 294 26.820 38.491 40.588 1.00 11.78 C

ATOM 11114 OH TYR D 294 26.368 38.335 41.879 1.00 11.88 O

ATOM 11115 CE2 TYR D 294 27.269 39.731 40.170 1.00 11.98 C

ATOM 11116 CD2 TYR D 294 27.725 39.892 38.863 1.00 11.87 C

ATOM 11117 C TYR D 294 27.867 40.272 34.366 1.00 11.01 C

ATOM 11118 O TYR D 294 28.196 41.446 34.196 1.00 10.94 O

ATOM 11119 N ALA D 295 28.026 39.337 33.430 1.00 11.17 N

ATOM 11120 CA ALA D 295 28.609 39.660 32.125 1.00 11.55 C

ATOM 11121 CB ALA D 295 29.271 38.432 31.503 1.00 11.45 C

ATOM 11122 C ALA D 295 27.583 40.284 31.170 1.00 11.86 C

ATOM 11123 O ALA D 295 27.953 40.960 30.209 1.00 12.13 O

ATOM 11124 N LYS D 296 26.299 40.058 31.453 1.00 12.33 N

ATOM 11125 CA LYS D 296 25.177 40.664 30.714 1.00 12.60 C

ATOM 11126 CB LYS D 296 25.134 42.181 30.905 1.00 12.90 C

ATOM 11127 CG LYS D 296 25.101 42.700 32.325 1.00 14.00 C

ATOM 11128 CD LYS D 296 24.460 44.072 32.272 1.00 16.56 C

ATOM 11129 CE LYS D 296 25.239 45.115 33.017 1.00 18.56 C

ATOM 11130 NZ LYS D 296 24.544 46.429 32.868 1.00 19.73 N W2025-7029WO / AM102903-PCT

ATOM 11131 C LYS D 296 25.180 40.370 29.216 1.00 12.73 C

ATOM 11132 O LYS D 296 24.819 41.239 28.405 1.00 12.64 O

ATOM 11133 N GLU D 297 25.579 39.161 28.841 1.00 12.66 N

ATOM 11134 CA GLU D 297 25.661 38.823 27.425 1.00 13.24 C

ATOM 11135 CB GLU D 297 27.081 38.397 27.045 1.00 13.01 C

ATOM 11136 CG GLU D 297 28.132 39.485 27.291 1.00 13.97 C

ATOM 11137 CD GLU D 297 29.549 39.042 26.964 1.00 14.31 C

ATOM 11138 OEl GLU D 297 29.733 38.287 25.988 1.00 15.54 O

ATOM 11139 OE2 GLU D 297 30.485 39.458 27.682 1.00 16.24 O

ATOM 11140 C GLU D 297 24.636 37.766 27.049 1.00 12.93 C

ATOM 11141 O GLU D 297 24.678 36.646 27.551 1.00 12.88 O

ATOM 11142 N SER D 298 23.706 38.141 26.172 1.00 13.12 N

ATOM 11143 CA SER D 298 22.694 37.214 25.662 1.00 12.82 C

ATOM 11144 CB SER D 298 21.776 37.908 24.648 1.00 12.89 C

ATOM 11145 OG SER D 298 20.821 36.995 24.125 1.00 13.22 O

ATOM 11146 C SER D 298 23.354 35.995 25.027 1.00 12.43 C

ATOM 11147 O SER D 298 24.264 36.130 24.204 1.00 12.37 O

ATOM 11148 N GLY D 299 22.906 34.810 25.444 1.00 11.88 N

ATOM 11149 CA GLY D 299 23.412 33.547 24.917 1.00 11.13 C

ATOM 11150 C GLY D 299 24.812 33.161 25.367 1.00 10.71 C

ATOM 11151 O GLY D 299 25.405 32.235 24.812 1.00 10.81 O

ATOM 11152 N ILE D 300 25.335 33.866 26.370 1.00 10.03 N

ATOM 11153 CA ILE D 300 26.693 33.648 26.875 1.00 9.30 C

ATOM 11154 CB ILE D 300 27.688 34.740 26.354 1.00 9.33 C

ATOM 11155 CGl ILE D 300 27.799 34.730 24.818 1.00 9.98 C

ATOM 11156 CDl ILE D 300 28.950 33.925 24.270 1.00 11.05 C

ATOM 11157 CG2 ILE D 300 29.073 34.608 27.024 1.00 9.25 C

ATOM 11158 C ILE D 300 26.703 33.692 28.402 1.00 8.88 C

ATOM 11159 O ILE D 300 26.135 34.609 28.999 1.00 8.59 O

ATOM 11160 N TRP D 301 27.351 32.705 29.022 1.00 8.08 N

ATOM 11161 CA TRP D 301 27.695 32.778 30.442 1.00 7.74 C

ATOM 11162 CB TRP D 301 27.063 31.634 31.233 1.00 7.59 C

ATOM 11163 CG TRP D 301 25.595 31.768 31.505 1.00 7.57 C

ATOM 11164 CDl TRP D 301 24.867 32.922 31.591 1.00 8.20 C

ATOM 11165 NEl TRP D 301 23.552 32.634 31.883 1.00 7.62 N

ATOM 11166 CE2 TRP D 301 23.418 31.275 32.003 1.00 8.04 C

ATOM 11167 CD2 TRP D 301 24.688 30.700 31.780 1.00 7.87 C

ATOM 11168 CE3 TRP D 301 24.823 29.305 31.844 1.00 7.73 C

ATOM 11169 CZ3 TRP D 301 23.702 28.541 32.124 1.00 7.81 C

ATOM 11170 CH2 TRP D 301 22.452 29.141 32.338 1.00 7.58 C

ATOM 11171 CZ2 TRP D 301 22.289 30.504 32.280 1.00 7.98 C

ATOM 11172 C TRP D 301 29.200 32.734 30.663 1.00 7.31 C

ATOM 11173 O TRP D 301 29.883 31.868 30.118 1.00 7.07 O

ATOM 11174 N ALA D 302 29.707 33.660 31.479 1.00 7.17 N

ATOM 11175 CA ALA D 302 31.093 33.605 31.965 1.00 6.91 C

ATOM 11176 CB ALA D 302 31.389 34.807 32.858 1.00 6.83 C

ATOM 11177 C ALA D 302 31.290 32.307 32.739 1.00 6.74 C

ATOM 11178 O ALA D 302 30.315 31.745 33.252 1.00 6.59 O

ATOM 11179 N TYR D 303 32.529 31.817 32.826 1.00 6.58 N

ATOM 11180 CA TYR D 303 32.771 30.567 33.558 1.00 6.74 C

ATOM 11181 CB TYR D 303 34.263 30.180 33.611 1.00 6.34 C

ATOM 11182 CG TYR D 303 34.516 28.887 34.383 1.00 6.27 C

ATOM 11183 CDl TYR D 303 33.992 27.665 33.936 1.00 5.07 C

ATOM 11184 CEl TYR D 303 34.214 26.480 34.646 1.00 5.46 C

ATOM 11185 CZ TYR D 303 34.967 26.513 35.815 1.00 6.36 C

ATOM 11186 OH TYR D 303 35.196 25.346 36.517 1.00 6.17 O

ATOM 11187 CE2 TYR D 303 35.508 27.707 36.269 1.00 5.02 C

ATOM 11188 CD2 TYR D 303 35.275 28.886 35.560 1.00 5.21 C

ATOM 11189 C TYR D 303 32.175 30.614 34.967 1.00 6.74 C

ATOM 11190 O TYR D 303 31.559 29.643 35.415 1.00 7.38 O

ATOM 11191 N TYR D 304 32.344 31.746 35.649 1.00 6.69 N

ATOM 11192 CA TYR D 304 31.831 31.907 37.012 1.00 6.46 C

ATOM 11193 CB TYR D 304 32.462 33.115 37.733 1.00 6.23 C W2025-7029WO / AM102903-PCT

ATOM 11194 CG TYR D 304 32.194 34.492 37.141 1.00 6.16 C

ATOM 11195 CDl TYR D 304 33.146 35.121 36.334 1.00 5.44 C

ATOM 11196 CEl TYR D 304 32.921 36.391 35.810 1.00 5.41 C

ATOM 11197 CZ TYR D 304 31.731 37.050 36.097 1.00 6.41 C

ATOM 11198 OH TYR D 304 31.497 38.306 35.580 1.00 6.64 O

ATOM 11199 CE2 TYR D 304 30.774 36.452 36.902 1.00 5.90 C

ATOM 11200 CD2 TYR D 304 31.015 35.183 37.428 1.00 4.64 C

ATOM 11201 C TYR D 304 30.304 31.920 37.089 1.00 6.40 C

ATOM 11202 O TYR D 304 29.739 31.478 38.078 1.00 6.08 O

ATOM 11203 N GLU D 305 29.647 32.398 36.034 1.00 6.50 N

ATOM 11204 CA GLU D 305 28.188 32.303 35.928 1.00 6.68 C

ATOM 11205 CB GLU D 305 27.663 33.217 34.816 1.00 6.61 C

ATOM 11206 CG GLU D 305 27.799 34.709 35.159 1.00 6.74 C

ATOM 11207 CD GLU D 305 27.426 35.630 34.012 1.00 6.74 C

ATOM 11208 OEl GLU D 305 27.613 35.242 32.834 1.00 7.82 O

ATOM 11209 OE2 GLU D 305 26.948 36.753 34.291 1.00 6.12 O

ATOM 11210 C GLU D 305 27.713 30.855 35.732 1.00 6.82 C

ATOM 11211 O GLU D 305 26.638 30.483 36.201 1.00 6.47 O

ATOM 11212 N ILE D 306 28.522 30.049 35.039 1.00 7.10 N

ATOM 11213 CA ILE D 306 28.244 28.619 34.863 1.00 7.10 C

ATOM 11214 CB ILE D 306 29.151 27.981 33.768 1.00 7.23 C

ATOM 11215 CGl ILE D 306 28.803 28.542 32.383 1.00 6.86 C

ATOM 11216 CDl ILE D 306 29.930 28.421 31.347 1.00 7.12 C

ATOM 11217 CG2 ILE D 306 29.023 26.453 33.765 1.00 6.82 C

ATOM 11218 C ILE D 306 28.370 27.861 36.196 1.00 7.36 C

ATOM 11219 O ILE D 306 27.602 26.933 36.464 1.00 7.41 O

ATOM 11220 N CYS D 307 29.331 28.262 37.030 1.00 7.42 N

ATOM 11221 CA CYS D 307 29.489 27.670 38.363 1.00 7.52 C

ATOM 11222 CB CYS D 307 30.741 28.214 39.054 1.00 7.84 C

ATOM 11223 SG CYS D 307 32.263 27.729 38.213 1.00 8.08

ATOM 11224 C CYS D 307 28.245 27.862 39.239 1.00 7.54 C

ATOM 11225 O CYS D 307 27.839 26.946 39.950 1.00 7.10 O

ATOM 11226 N THR D 308 27.646 29.051 39.169 1.00 7.68 N

ATOM 11227 CA THR D 308 26.362 29.336 39.827 1.00 7.99 C

ATOM 11228 CB THR D 308 25.945 30.819 39.638 1.00 7.80 C

ATOM 11229 OGl THR D 308 26.990 31.675 40.112 1.00 8.41 O

ATOM 11230 CG2 THR D 308 24.649 31.141 40.394 1.00 8.25 C

ATOM 11231 C THR D 308 25.265 28.416 39.278 1.00 8.10 C

ATOM 11232 O THR D 308 24.463 27.882 40.043 1.00 8.18 O

ATOM 11233 N PHE D 309 25.248 28.239 37.956 1.00 8.14 N

ATOM 11234 CA PHE D 309 24.321 27.329 37.270 1.00 8.66 C

ATOM 11235 CB PHE D 309 24.603 27.335 35.764 1.00 8.32 C

ATOM 11236 CG PHE D 309 23.636 26.522 34.931 1.00 8.58 C

ATOM 11237 CDl PHE D 309 22.264 26.770 34.964 1.00 8.54 C

ATOM 11238 CEl PHE D 309 21.381 26.034 34.166 1.00 8.55 C

ATOM 11239 CZ PHE D 309 21.872 25.049 33.313 1.00 8.66 C

ATOM 11240 CE2 PHE D 309 23.244 24.804 33.257 1.00 7.97 C

ATOM 11241 CD2 PHE D 309 24.115 25.548 34.056 1.00 8.54 C

ATOM 11242 C PHE D 309 24.424 25.923 37.857 1.00 9.05 C

ATOM 11243 O PHE D 309 23.405 25.283 38.142 1.00 9.10 O

ATOM 11244 N LEU D 310 25.656 25.469 38.074 1.00 9.43 N

ATOM 11245 CA LEU D 310 25.913 24.165 38.685 1.00 10.09 C

ATOM 11246 CB LEU D 310 27.378 23.761 38.483 1.00 9.89 C

ATOM 11247 CG LEU D 310 27.901 23.713 37.037 1.00 10.06 C

ATOM 11248 CDl LEU D 310 29.421 23.538 36.995 1.00 9.20 C

ATOM 11249 CD2 LEU D 310 27.210 22.616 36.232 1.00 10.13 C

ATOM 11250 C LEU D 310 25.537 24.141 40.176 1.00 10.74 C

ATOM 11251 O LEU D 310 24.987 23.151 40.662 1.00 10.79 O

ATOM 11252 N LYS D 311 25.832 25.235 40.883 1.00 11.24 N

ATOM 11253 CA LYS D 311 25.480 25.392 42.301 1.00 12.18 C

ATOM 11254 CB LYS D 311 25.926 26.766 42.828 1.00 12.24 C

ATOM 11255 CG LYS D 311 27.367 26.853 43.322 1.00 13.83 C

ATOM 11256 CD LYS D 311 27.757 28.312 43.606 1.00 14.12 C W2025-7029WO / AM102903-PCT

ATOM 11257 CE LYS D 311 28.968 28.405 44.529 1.00 17.63 C

ATOM 11258 NZ LYS D 311 29.241 29.807 45.010 1.00 18.57 N

ATOM 11259 C LYS D 311 23.981 25.233 42.535 1.00 11.69 C

ATOM 11260 O LYS D 311 23.558 24.645 43.529 1.00 11.83 O

ATOM 11261 N ASN D 312 23.186 25.762 41.609 1.00 11.51 N

ATOM 11262 CA ASN D 312 21.732 25.789 41.757 1.00 11.11 C

ATOM 11263 CB ASN D 312 21.177 27.149 41.304 1.00 10.87 C

ATOM 11264 CG ASN D 312 21.560 28.294 42.261 1.00 10.91 C

ATOM 11265 ODl ASN D 312 21.719 28.089 43.464 1.00 9.97 O

ATOM 11266 ND2 ASN D 312 21.696 29.501 41.723 1.00 10.48 N

ATOM 11267 C ASN D 312 20.992 24.588 41.128 1.00 11.18 C

ATOM 11268 O ASN D 312 19.775 24.630 40.908 1.00 11.17 O

ATOM 11269 N GLY D 313 21.738 23.515 40.864 1.00 11.11 N

ATOM 11270 CA GLY D 313 21.149 22.207 40.587 1.00 10.98 C

ATOM 11271 C GLY D 313 21.317 21.606 39.199 1.00 11.06 C

ATOM 11272 O GLY D 313 20.813 20.513 38.943 1.00 10.69 O

ATOM 11273 N ALA D 314 22.021 22.301 38.304 1.00 11.05 N

ATOM 11274 CA ALA D 314 22.163 21.831 36.920 1.00 11.21 C

ATOM 11275 CB ALA D 314 22.901 22.847 36.076 1.00 10.85 C

ATOM 11276 C ALA D 314 22.854 20.475 36.847 1.00 11.22 C

ATOM 11277 O ALA D 314 23.667 20.138 37.707 1.00 11.36 O

ATOM 11278 N THR D 315 22.516 19.707 35.813 1.00 11.39 N

ATOM 11279 CA THR D 315 23.105 18.390 35.594 1.00 11.55 C

ATOM 11280 CB THR D 315 22.144 17.478 34.807 1.00 11.35 C

ATOM 11281 OGl THR D 315 20.935 17.308 35.558 1.00 11.47 O

ATOM 11282 CG2 THR D 315 22.766 16.106 34.541 1.00 11.46 C

ATOM 11283 C THR D 315 24.418 18.545 34.843 1.00 11.60 C

ATOM 11284 O THR D 315 24.482 19.261 33.839 1.00 11.70 O

ATOM 11285 N GLN D 316 25.460 17.888 35.346 1.00 11.54 N

ATOM 11286 CA GLN D 316 26.774 17.921 34.714 1.00 11.93 C

ATOM 11287 CB GLN D 316 27.891 17.736 35.748 1.00 12.13 C

ATOM 11288 CG GLN D 316 28.034 18.911 36.723 1.00 14.71 C

ATOM 11289 CD GLN D 316 29.481 19.198 37.119 1.00 18.37 C

ATOM 11290 OEl GLN D 316 29.855 19.061 38.286 1.00 18.83 O

ATOM 11291 NE2 GLN D 316 30.300 19.606 36.144 1.00 18.55 N

ATOM 11292 C GLN D 316 26.876 16.873 33.603 1.00 11.33 C

ATOM 11293 O GLN D 316 26.644 15.679 33.832 1.00 11.28 O

ATOM 11294 N GLY D 317 27.211 17.336 32.402 1.00 10.66 N

ATOM 11295 CA GLY D 317 27.409 16.464 31.245 1.00 9.90 C

ATOM 11296 C GLY D 317 28.848 16.471 30.747 1.00 9.66 C

ATOM 11297 O GLY D 317 29.599 17.408 31.008 1.00 9.59 O

ATOM 11298 N TRP D 318 29.232 15.410 30.043 1.00 9.27 N

ATOM 11299 CA TRP D 318 30.547 15.331 29.405 1.00 8.82 C

ATOM 11300 CB TRP D 318 31.489 14.416 30.208 1.00 8.83 C

ATOM 11301 CG TRP D 318 32.925 14.410 29.717 1.00 8.78 C

ATOM 11302 CDl TRP D 318 33.582 13.372 29.122 1.00 9.06 C

ATOM 11303 NEl TRP D 318 34.878 13.735 28.816 1.00 8.62 N

ATOM 11304 CE2 TRP D 318 35.080 15.031 29.215 1.00 8.88 C

ATOM 11305 CD2 TRP D 318 33.869 15.491 29.792 1.00 9.16 C

ATOM 11306 CE3 TRP D 318 33.810 16.803 30.287 1.00 8.81 C

ATOM 11307 CZ3 TRP D 318 34.951 17.608 30.190 1.00 8.90 C

ATOM 11308 CH2 TRP D 318 36.139 17.118 29.609 1.00 8.51 C

ATOM 11309 CZ2 TRP D 318 36.221 15.836 29.119 1.00 8.70 C

ATOM 11310 C TRP D 318 30.410 14.865 27.954 1.00 8.72 C

ATOM 11311 O TRP D 318 29.853 13.800 27.679 1.00 8.88 O

ATOM 11312 N ASP D 319 30.885 15.698 27.034 1.00 8.46 N

ATOM 11313 CA ASP D 319 30.929 15.388 25.606 1.00 8.07 C

ATOM 11314 CB ASP D 319 30.758 16.688 24.801 1.00 7.78 C

ATOM 11315 CG ASP D 319 30.794 16.489 23.282 1.00 7.56 C

ATOM 11316 ODl ASP D 319 30.586 17.494 22.580 1.00 7.49 O

ATOM 11317 OD2 ASP D 319 31.040 15.376 22.776 1.00 7.32 O

ATOM 11318 C ASP D 319 32.286 14.725 25.384 1.00 8.14 C

ATOM 11319 O ASP D 319 33.293 15.388 25.104 1.00 7.88 O W2025-7029WO / AM102903-PCT

ATOM 11320 N ALA D 320 32.303 13.404 25.554 1.00 7.99 N

ATOM 11321 CA ALA D 320 33.549 12.635 25.604 1.00 8.07 C

ATOM 11322 CB ALA D 320 33.285 11.209 26.100 1.00 8.19 C

ATOM 11323 C ALA D 320 34.370 12.628 24.300 1.00 7.99 C

ATOM 11324 O ALA D 320 35.582 12.804 24.349 1.00 7.75 O

ATOM 11325 N PRO D 321 33.721 12.438 23.132 1.00 8.18 N

ATOM 11326 CA PRO D 321 34.546 12.476 21.921 1.00 8.21 C

ATOM 11327 CB PRO D 321 33.573 12.101 20.798 1.00 8.41 C

ATOM 11328 CG PRO D 321 32.213 12.292 21.351 1.00 8.53 C

ATOM 11329 CD PRO D 321 32.299 12.174 22.837 1.00 8.20 C

ATOM 11330 C PRO D 321 35.189 13.837 21.651 1.00 8.20 C

ATOM 11331 O PRO D 321 36.218 13.897 20.978 1.00 8.28 O

ATOM 11332 N GLN D 322 34.605 14.909 22.189 1.00 7.85 N

ATOM 11333 CA GLN D 322 35.096 16.265 21.928 1.00 7.74 C

ATOM 11334 CB GLN D 322 33.940 17.179 21.493 1.00 7.60 C

ATOM 11335 CG GLN D 322 33.167 16.636 20.285 1.00 7.47 C

ATOM 11336 CD GLN D 322 32.270 17.659 19.621 1.00 7.87 C

ATOM 11337 OEl GLN D 322 32.564 18.139 18.517 1.00 8.24 O

ATOM 11338 NE2 GLN D 322 31.157 17.992 20.277 1.00 7.09 N

ATOM 11339 C GLN D 322 35.899 16.860 23.102 1.00 7.57 C

ATOM 11340 O GLN D 322 36.492 17.934 22.969 1.00 7.32 O

ATOM 11341 N GLU D 323 35.916 16.136 24.226 1.00 7.46 N

ATOM 11342 CA GLU D 323 36.704 16.456 25.442 1.00 7.58 C

ATOM 11343 CB GLU D 323 38.225 16.400 25.180 1.00 8.07 C

ATOM 11344 CG GLU D 323 38.730 15.170 24.405 1.00 9.57 C

ATOM 11345 CD GLU D 323 38.696 13.871 25.198 1.00 13.04 C

ATOM 11346 OEl GLU D 323 39.029 12.828 24.595 1.00 15.15 O

ATOM 11347 OE2 GLU D 323 38.343 13.873 26.405 1.00 13.90 O

ATOM 11348 C GLU D 323 36.327 17.776 26.130 1.00 7.28 C

ATOM 11349 O GLU D 323 37.188 18.482 26.660 1.00 7.12 O

ATOM 11350 N VAL D 324 35.037 18.096 26.121 1.00 6.67 N

ATOM 11351 CA VAL D 324 34.536 19.336 26.708 1.00 6.25 C

ATOM 11352 CB VAL D 324 34.320 20.448 25.639 1.00 6.10 C

ATOM 11353 CGl VAL D 324 35.645 21.152 25.312 1.00 5.47 C

ATOM 11354 CG2 VAL D 324 33.667 19.877 24.381 1.00 4.76 C

ATOM 11355 C VAL D 324 33.243 19.084 27.489 1.00 6.34 C

ATOM 11356 O VAL D 324 32.476 18.174 27.147 1.00 6.36 O

ATOM 11357 N PRO D 325 33.016 19.867 28.560 1.00 6.32 N

ATOM 11358 CA PRO D 325 31.833 19.669 29.385 1.00 6.36 C

ATOM 11359 CB PRO D 325 32.234 20.315 30.707 1.00 6.68 C

ATOM 11360 CG PRO D 325 33.130 21.438 30.302 1.00 6.39 C

ATOM 11361 CD PRO D 325 33.871 20.956 29.078 1.00 6.15 C

ATOM 11362 C PRO D 325 30.587 20.349 28.825 1.00 6.62 C

ATOM 11363 O PRO D 325 30.673 21.181 27.925 1.00 6.21 O

ATOM 11364 N TYR D 326 29.434 19.960 29.352 1.00 7.01 N

ATOM 11365 CA TYR D 326 28.208 20.703 29.133 1.00 7.22 C

ATOM 11366 CB TYR D 326 27.514 20.301 27.821 1.00 7.46 C

ATOM 11367 CG TYR D 326 26.895 18.919 27.784 1.00 7.48 C

ATOM 11368 CDl TYR D 326 25.564 18.722 28.156 1.00 7.54 C

ATOM 11369 CEl TYR D 326 24.982 17.462 28.112 1.00 7.52 C

ATOM 11370 CZ TYR D 326 25.721 16.382 27.674 1.00 8.03 C

ATOM 11371 OH TYR D 326 25.137 15.143 27.631 1.00 8.43 O

ATOM 11372 CE2 TYR D 326 27.048 16.547 27.283 1.00 8.49 C

ATOM 11373 CD2 TYR D 326 27.624 17.819 27.338 1.00 7.59 C

ATOM 11374 C TYR D 326 27.304 20.542 30.349 1.00 7.34 C

ATOM 11375 O TYR D 326 27.518 19.660 31.174 1.00 7.24 O

ATOM 11376 N ALA D 327 26.317 21.416 30.478 1.00 7.52 N

ATOM 11377 CA ALA D 327 25.406 21.338 31.616 1.00 7.90 C

ATOM 11378 CB ALA D 327 25.895 22.224 32.752 1.00 7.66 C

ATOM 11379 C ALA D 327 24.001 21.720 31.200 1.00 8.19 C

ATOM 11380 O ALA D 327 23.816 22.469 30.242 1.00 8.55 O

ATOM 11381 N TYR D 328 23.006 21.212 31.921 1.00 8.59 N

ATOM 11382 CA TYR D 328 21.623 21.507 31.576 1.00 9.12 C W2025-7029WO / AM102903-PCT

ATOM 11383 CB TYR D 328 21.124 20.588 30.440 1.00 9.41 C

ATOM 11384 CG TYR D 328 21.084 19.113 30.791 1.00 10.09 C

ATOM 11385 CDl TYR D 328 22.197 18.295 30.583 1.00 9.75 C

ATOM 11386 CEl TYR D 328 22.163 16.942 30.900 1.00 10.10 C

ATOM 11387 CZ TYR D 328 21.006 16.394 31.438 1.00 10.13 C

ATOM 11388 OH TYR D 328 20.970 15.056 31.758 1.00 10.81 O

ATOM 11389 CE2 TYR D 328 19.889 17.184 31.658 1.00 10.55 C

ATOM 11390 CD2 TYR D 328 19.931 18.535 31.329 1.00 10.24 C

ATOM 11391 C TYR D 328 20.697 21.442 32.784 1.00 9.22 C

ATOM 11392 O TYR D 328 20.965 20.731 33.754 1.00 8.90 O

ATOM 11393 N GLN D 329 19.607 22.196 32.704 1.00 9.52 N

ATOM 11394 CA GLN D 329 18.577 22.210 33.736 1.00 9.93 C

ATOM 11395 CB GLN D 329 18.987 23.136 34.880 1.00 10.13 C

ATOM 11396 CG GLN D 329 18.235 22.917 36.185 1.00 10.19 C

ATOM 11397 CD GLN D 329 18.750 23.814 37.301 1.00 10.57 C

ATOM 11398 OEl GLN D 329 19.251 24.913 37.052 1.00 12.12 O

ATOM 11399 NE2 GLN D 329 18.626 23.348 38.537 1.00 10.87 N

ATOM 11400 C GLN D 329 17.291 22.699 33.091 1.00 9.64 C

ATOM 11401 O GLN D 329 17.263 23.779 32.501 1.00 9.82 O

ATOM 11402 N GLY D 330 16.236 21.893 33.182 1.00 9.66 N

ATOM 11403 CA GLY D 330 14.963 22.208 32.524 1.00 9.42 C

ATOM 11404 C GLY D 330 15.159 22.395 31.031 1.00 9.25 C

ATOM 11405 O GLY D 330 15.690 21.506 30.354 1.00 9.48 O

ATOM 11406 N ASN D 331 14.747 23.551 30.515 1.00 8.81 N

ATOM 11407 CA ASN D 331 14.956 23.862 29.099 1.00 8.59 C

ATOM 11408 CB ASN D 331 13.706 24.511 28.486 1.00 8.46 C

ATOM 11409 CG ASN D 331 13.362 25.849 29.118 1.00 8.87 C

ATOM 11410 ODl ASN D 331 13.852 26.188 30.201 1.00 8.45 O

ATOM 11411 ND2 ASN D 331 12.503 26.619 28.443 1.00 7.73 N

ATOM 11412 C ASN D 331 16.212 24.702 28.819 1.00 8.23 C

ATOM 11413 O ASN D 331 16.300 25.368 27.787 1.00 8.19 O

ATOM 11414 N VAL D 332 17.177 24.674 29.735 1.00 8.07 N

ATOM 11415 CA VAL D 332 18.402 25.472 29.574 1.00 7.95 C

ATOM 11416 CB VAL D 332 18.562 26.541 30.701 1.00 8.19 C

ATOM 11417 CGl VAL D 332 19.832 27.378 30.497 1.00 8.05 C

ATOM 11418 CG2 VAL D 332 17.330 27.456 30.761 1.00 7.55 C

ATOM 11419 C VAL D 332 19.632 24.567 29.482 1.00 7.89 C

ATOM 11420 O VAL D 332 19.803 23.668 30.290 1.00 7.87 O

ATOM 11421 N TRP D 333 20.488 24.842 28.497 1.00 7.89 N

ATOM 11422 CA TRP D 333 21.624 23.993 28.150 1.00 7.58 C

ATOM 11423 CB TRP D 333 21.276 23.212 26.881 1.00 7.87 C

ATOM 11424 CG TRP D 333 22.161 22.038 26.544 1.00 7.89 C

ATOM 11425 CDl TRP D 333 21.913 20.724 26.820 1.00 7.83 C

ATOM 11426 NEl TRP D 333 22.934 19.937 26.337 1.00 8.63 N

ATOM 11427 CE2 TRP D 333 23.862 20.735 25.720 1.00 7.90 C

ATOM 11428 CD2 TRP D 333 23.412 22.070 25.832 1.00 8.05 C

ATOM 11429 CE3 TRP D 333 24.193 23.098 25.277 1.00 8.08 C

ATOM 11430 CZ3 TRP D 333 25.394 22.761 24.639 1.00 8.26 C

ATOM 11431 CH2 TRP D 333 25.818 21.420 24.552 1.00 8.00 C

ATOM 11432 CZ2 TRP D 333 25.068 20.397 25.083 1.00 8.46 C

ATOM 11433 C TRP D 333 22.811 24.900 27.870 1.00 7.31 C

ATOM 11434 O TRP D 333 22.663 25.927 27.205 1.00 7.31 O

ATOM 11435 N VAL D 334 23.985 24.530 28.368 1.00 6.83 N

ATOM 11436 CA VAL D 334 25.187 25.336 28.133 1.00 6.53 C

ATOM 11437 CB VAL D 334 25.527 26.252 29.363 1.00 6.32 C

ATOM 11438 CGl VAL D 334 25.868 25.421 30.615 1.00 5.76 C

ATOM 11439 CG2 VAL D 334 26.656 27.246 29.028 1.00 5.72 C

ATOM 11440 C VAL D 334 26.377 24.460 27.732 1.00 6.25 C

ATOM 11441 O VAL D 334 26.608 23.423 28.329 1.00 6.37 O

ATOM 11442 N GLY D 335 27.115 24.888 26.711 1.00 6.45 N

ATOM 11443 CA GLY D 335 28.325 24.187 26.274 1.00 6.47 C

ATOM 11444 C GLY D 335 29.531 25.051 26.563 1.00 6.58 C

ATOM 11445 O GLY D 335 29.578 26.209 26.148 1.00 6.95 O W2025-7029WO / AM102903-PCT

ATOM 11446 N TYR D 336 30.512 24.498 27.274 1.00 6.62 N

ATOM 11447 CA TYR D 336 31.594 25.317 27.821 1.00 6.63 C

ATOM 11448 CB TYR D 336 31.146 25.964 29.145 1.00 6.41 C

ATOM 11449 CG TYR D 336 30.895 24.980 30.278 1.00 6.36 C

ATOM 11450 CDl TYR D 336 29.781 24.133 30.269 1.00 6.58 C

ATOM 11451 CEl TYR D 336 29.550 23.230 31.310 1.00 5.44 C

ATOM 11452 CZ TYR D 336 30.435 23.177 32.373 1.00 6.35 C

ATOM 11453 OH TYR D 336 30.222 22.293 33.406 1.00 5.42 O

ATOM 11454 CE2 TYR D 336 31.542 24.009 32.404 1.00 6.17 C

ATOM 11455 CD2 TYR D 336 31.762 24.907 31.364 1.00 5.56 C

ATOM 11456 C TYR D 336 32.910 24.572 28.023 1.00 6.70 C

ATOM 11457 O TYR D 336 33.105 23.482 27.487 1.00 6.57 O

ATOM 11458 N ASP D 337 33.804 25.193 28.793 1.00 6.69 N

ATOM 11459 CA ASP D 337 35.083 24.609 29.184 1.00 6.97 C

ATOM 11460 CB ASP D 337 36.248 25.342 28.505 1.00 6.90 C

ATOM 11461 CG ASP D 337 36.566 24.798 27.129 1.00 7.76 C

ATOM 11462 ODl ASP D 337 35.902 25.190 26.141 1.00 8.20 O

ATOM 11463 OD2 ASP D 337 37.507 23.986 27.033 1.00 8.53 O

ATOM 11464 C ASP D 337 35.276 24.654 30.703 1.00 6.91 C

ATOM 11465 O ASP D 337 34.876 25.618 31.371 1.00 6.69 O

ATOM 11466 N ASN D 338 35.895 23.604 31.235 1.00 6.93 N

ATOM 11467 CA ASN D 338 36.252 23.536 32.650 1.00 7.23 C

ATOM 11468 CB ASN D 338 35.347 22.540 33.417 1.00 7.30 C

ATOM 11469 CG ASN D 338 35.423 21.099 32.879 1.00 7.65 C

ATOM 11470 ODl ASN D 338 36.233 20.765 32.008 1.00 8.27 O

ATOM 11471 ND2 ASN D 338 34.552 20.243 33.404 1.00 8.44 N

ATOM 11472 C ASN D 338 37.737 23.222 32.825 1.00 7.24 C

ATOM 11473 O ASN D 338 38.489 23.223 31.851 1.00 7.20 O

ATOM 11474 N VAL D 339 38.153 22.967 34.062 1.00 7.48 N

ATOM 11475 CA VAL D 339 39.553 22.675 34.364 1.00 7.74 C

ATOM 11476 CB VAL D 339 39.780 22.509 35.899 1.00 7.72 C

ATOM 11477 CGl VAL D 339 41.178 21.966 36.203 1.00 7.21 C

ATOM 11478 CG2 VAL D 339 39.551 23.843 36.614 1.00 7.21 C

ATOM 11479 C VAL D 339 40.039 21.450 33.573 1.00 8.28 C

ATOM 11480 O VAL D 339 41.123 21.476 32.972 1.00 8.34 O

ATOM 11481 N LYS D 340 39.216 20.401 33.553 1.00 8.72 N

ATOM 11482 CA LYS D 340 39.531 19.152 32.844 1.00 9.08 C

ATOM 11483 CB LYS D 340 38.431 18.114 33.092 1.00 8.97 C

ATOM 11484 CG LYS D 340 38.739 16.722 32.564 1.00 9.74 C

ATOM 11485 CD LYS D 340 37.586 15.763 32.837 1.00 10.32 C

ATOM 11486 CE LYS D 340 37.953 14.338 32.449 1.00 13.10 C

ATOM 11487 NZ LYS D 340 36.857 13.385 32.792 1.00 15.43 N

ATOM 11488 C LYS D 340 39.773 19.355 31.336 1.00 8.73 C

ATOM 11489 O LYS D 340 40.781 18.888 30.799 1.00 8.33 O

ATOM 11490 N SER D 341 38.858 20.059 30.666 1.00 8.58 N

ATOM 11491 CA SER D 341 38.953 20.275 29.216 1.00 8.14 C

ATOM 11492 CB SER D 341 37.645 20.835 28.638 1.00 7.98 C

ATOM 11493 OG SER D 341 37.346 22.130 29.130 1.00 7.31 O

ATOM 11494 C SER D 341 40.144 21.158 28.854 1.00 8.34 C

ATOM 11495 O SER D 341 40.823 20.912 27.857 1.00 8.08 O

ATOM 11496 N PHE D 342 40.392 22.173 29.682 1.00 8.64 N

ATOM 11497 CA PHE D 342 41.540 23.058 29.527 1.00 9.00 C

ATOM 11498 CB PHE D 342 41.509 24.175 30.584 1.00 8.50 C

ATOM 11499 CG PHE D 342 40.969 25.509 30.084 1.00 8.39 C

ATOM 11500 CDl PHE D 342 39.823 25.580 29.295 1.00 7.55 C

ATOM 11501 CEl PHE D 342 39.337 26.812 28.847 1.00 7.86 C

ATOM 11502 CZ PHE D 342 39.988 27.993 29.209 1.00 7.79 C

ATOM 11503 CE2 PHE D 342 41.129 27.935 30.003 1.00 6.74 C

ATOM 11504 CD2 PHE D 342 41.609 26.699 30.436 1.00 6.82 C

ATOM 11505 C PHE D 342 42.847 22.269 29.613 1.00 9.48 C

ATOM 11506 O PHE D 342 43.736 22.457 28.782 1.00 9.79 O

ATOM 11507 N ASP D 343 42.955 21.385 30.608 1.00 10.22 N

ATOM 11508 CA ASP D 343 44.165 20.574 30.800 1.00 10.63 C W2025-7029WO / AM102903-PCT

ATOM 11509 CB ASP D 343 44.125 19.825 32.132 1.00 11.19 C

ATOM 11510 CG ASP D 343 45.487 19.267 32.532 1.00 14.00 C

ATOM 11511 ODl ASP D 343 46.437 20.070 32.712 1.00 16.53 O

ATOM 11512 OD2 ASP D 343 45.608 18.026 32.673 1.00 14.88 O

ATOM 11513 C ASP D 343 44.398 19.602 29.641 1.00 10.26 C

ATOM 11514 O ASP D 343 45.527 19.474 29.154 1.00 9.93 O

ATOM 11515 N ILE D 344 43.329 18.939 29.198 1.00 9.86 N

ATOM 11516 CA ILE D 344 43.388 18.040 28.037 1.00 9.76 C

ATOM 11517 CB ILE D 344 42.001 17.396 27.719 1.00 9.59 C

ATOM 11518 CGl ILE D 344 41.606 16.387 28.806 1.00 9.98 C

ATOM 11519 CDl ILE D 344 40.140 15.919 28.737 1.00 9.60 C

ATOM 11520 CG2 ILE D 344 42.004 16.710 26.346 1.00 9.92 C

ATOM 11521 C ILE D 344 43.935 18.791 26.820 1.00 9.57 C

ATOM 11522 O ILE D 344 44.884 18.338 26.182 1.00 9.93 O

ATOM 11523 N LYS D 345 43.337 19.944 26.523 1.00 9.28 N

ATOM 11524 CA LYS D 345 43.752 20.791 25.400 1.00 8.98 C

ATOM 11525 CB LYS D 345 42.812 21.987 25.271 1.00 8.88 C

ATOM 11526 CG LYS D 345 41.440 21.672 24.717 1.00 8.04 C

ATOM 11527 CD LYS D 345 40.521 22.860 24.952 1.00 8.07 C

ATOM 11528 CE LYS D 345 39.129 22.579 24.475 1.00 7.58 C

ATOM 11529 NZ LYS D 345 38.296 23.799 24.502 1.00 7.05 N

ATOM 11530 C LYS D 345 45.195 21.290 25.517 1.00 8.60 C

ATOM 11531 O LYS D 345 45.910 21.374 24.515 1.00 8.41 O

ATOM 11532 N ALA D 346 45.606 21.629 26.737 1.00 8.39 N

ATOM 11533 CA ALA D 346 46.967 22.099 27.001 1.00 8.53 C

ATOM 11534 CB ALA D 346 47.090 22.596 28.430 1.00 8.50 C

ATOM 11535 C ALA D 346 47.999 21.006 26.716 1.00 8.71 C

ATOM 11536 O ALA D 346 49.035 21.274 26.105 1.00 8.72 O

ATOM 11537 N GLN D 347 47.706 19.777 27.147 1.00 9.00 N

ATOM 11538 CA GLN D 347 48.564 18.621 26.839 1.00 9.37 C

ATOM 11539 CB GLN D 347 48.103 17.357 27.583 1.00 9.51 C

ATOM 11540 CG GLN D 347 47.966 17.489 29.110 1.00 11.45 C

ATOM 11541 CD GLN D 347 49.223 18.008 29.801 1.00 13.91 C

ATOM 11542 OEl GLN D 347 50.347 17.676 29.416 1.00 15.45 O

ATOM 11543 NE2 GLN D 347 49.031 18.821 30.839 1.00 15.84 N

ATOM 11544 C GLN D 347 48.633 18.352 25.330 1.00 9.02 C

ATOM 11545 O GLN D 347 49.703 18.045 24.797 1.00 9.02 O

ATOM 11546 N TRP D 348 47.489 18.479 24.657 1.00 8.98 N

ATOM 11547 CA TRP D 348 47.390 18.300 23.201 1.00 8.92 C

ATOM 11548 CB TRP D 348 45.923 18.361 22.759 1.00 8.82 C

ATOM 11549 CG TRP D 348 45.727 18.336 21.262 1.00 8.70 C

ATOM 11550 CDl TRP D 348 45.659 17.230 20.461 1.00 8.97 C

ATOM 11551 NEl TRP D 348 45.477 17.602 19.149 1.00 8.57 N

ATOM 11552 CE2 TRP D 348 45.417 18.969 19.078 1.00 9.26 C

ATOM 11553 CD2 TRP D 348 45.569 19.469 20.393 1.00 9.16 C

ATOM 11554 CE3 TRP D 348 45.552 20.856 20.596 1.00 8.67 C

ATOM 11555 CZ3 TRP D 348 45.373 21.687 19.499 1.00 9.10 C

ATOM 11556 CH2 TRP D 348 45.219 21.158 18.200 1.00 8.88 C

ATOM 11557 CZ2 TRP D 348 45.237 19.808 17.973 1.00 9.39 C

ATOM 11558 C TRP D 348 48.221 19.332 22.434 1.00 8.98 C

ATOM 11559 O TRP D 348 48.938 18.998 21.481 1.00 8.66 O

ATOM 11560 N LEU D 349 48.105 20.584 22.867 1.00 8.98 N

ATOM 11561 CA LEU D 349 48.831 21.719 22.306 1.00 9.02 C

ATOM 11562 CB LEU D 349 48.370 22.979 23.052 1.00 9.11 C

ATOM 11563 CG LEU D 349 48.985 24.371 23.186 1.00 9.51 C

ATOM 11564 CDl LEU D 349 48.104 25.147 24.169 1.00 7.80 C

ATOM 11565 CD2 LEU D 349 50.433 24.399 23.656 1.00 8.32 C

ATOM 11566 C LEU D 349 50.341 21.516 22.432 1.00 9.06 C

ATOM 11567 O LEU D 349 51.089 21.739 21.472 1.00 9.14 O

ATOM 11568 N LYS D 350 50.779 21.090 23.614 1.00 9.07 N

ATOM 11569 CA LYS D 350 52.196 20.862 23.879 1.00 9.54 C

ATOM 11570 CB LYS D 350 52.430 20.521 25.352 1.00 9.73 C

ATOM 11571 CG LYS D 350 52 272 21.707 26.302 1.00 9.31 C W2025-7029WO / AM102903-PCT

ATOM 11572 CD LYS D 350 52.840 21.411 27.687 1.00 9.76 C

ATOM 11573 CE LYS D 350 52.034 20.364 28.440 1.00 9.06 C

ATOM 11574 NZ LYS D 350 52.639 20.028 29.767 1.00 7.76 N

ATOM 11575 C LYS D 350 52.773 19.764 22.985 1.00 9.90 C

ATOM 11576 O LYS D 350 53.852 19.933 22.405 1.00 9.90 O

ATOM 11577 N HIS D 351 52.050 18.651 22.873 1.00 10.19 N

ATOM 11578 CA HIS D 351 52.508 17.512 22.074 1.00 10.67 C

ATOM 11579 CB HIS D 351 51.621 16.279 22.279 1.00 11.02 C

ATOM 11580 CG HIS D 351 52.078 15.088 21.495 1.00 11.71 C

ATOM 11581 NDl HIS D 351 53.232 14.397 21.802 1.00 12.28 N

ATOM 11582 CEl HIS D 351 53.399 13.418 20.930 1.00 12.18 C

ATOM 11583 NE2 HIS D 351 52.401 13.453 20.065 1.00 11.74 N

ATOM 11584 CD2 HIS D 351 51.565 14.495 20.390 1.00 12.02 C

ATOM 11585 C HIS D 351 52.607 17.840 20.587 1.00 10.60 C

ATOM 11586 O HIS D 351 53.478 17.316 19.888 1.00 10.58 O

ATOM 11587 N ASN D 352 51.715 18.715 20.124 1.00 10.41 N

ATOM 11588 CA ASN D 352 51.701 19.197 18.748 1.00 10.34 C

ATOM 11589 CB ASN D 352 50.285 19.618 18.364 1.00 10.32 C

ATOM 11590 CG ASN D 352 49.410 18.439 18.001 1.00 11.08 C

ATOM 11591 ODl ASN D 352 49.414 17.987 16.857 1.00 12.06 O

ATOM 11592 ND2 ASN D 352 48.656 17.927 18.974 1.00 11.46 N

ATOM 11593 C ASN D 352 52.685 20.341 18.507 1.00 10.10 C

ATOM 11594 O ASN D 352 52.796 20.845 17.387 1.00 10.27 O

ATOM 11595 N LYS D 353 53.387 20.742 19.566 1.00 9.72 N

ATOM 11596 CA LYS D 353 54.443 21.757 19.504 1.00 9.73 C

ATOM 11597 CB LYS D 353 55.676 21.215 18.757 1.00 9.74 C

ATOM 11598 CG LYS D 353 56.386 20.075 19.480 1.00 11.16 C

ATOM 11599 CD LYS D 353 57.464 19.440 18.610 1.00 11.82 C

ATOM 11600 CE LYS D 353 58.363 18.515 19.421 1.00 15.49 C

ATOM 11601 NZ LYS D 353 59.577 18.111 18.643 1.00 17.37 N

ATOM 11602 C LYS D 353 53.974 23.111 18.934 1.00 8.72 C

ATOM 11603 O LYS D 353 54.709 23.784 18.206 1.00 8.21 O

ATOM 11604 N PHE D 354 52.744 23.499 19.275 1.00 7.89 N

ATOM 11605 CA PHE D 354 52.281 24.855 19.016 1.00 7.32 C

ATOM 11606 CB PHE D 354 50.755 24.939 19.087 1.00 7.39 C

ATOM 11607 CG PHE D 354 50.050 24.146 18.006 1.00 7.80 C

ATOM 11608 CDl PHE D 354 49.117 23.169 18.339 1.00 8.25 C

ATOM 11609 CEl PHE D 354 48.459 22.437 17.340 1.00 8.04 C

ATOM 11610 CZ PHE D 354 48.744 22.677 16.001 1.00 7.65 C

ATOM 11611 CE2 PHE D 354 49.676 23.645 15.661 1.00 8.17 C

ATOM 11612 CD2 PHE D 354 50.320 24.378 16.661 1.00 7.13 C

ATOM 11613 C PHE D 354 52.964 25.810 20.007 1.00 6.92 C

ATOM 11614 O PHE D 354 53.615 25.357 20.957 1.00 6.67 O

ATOM 11615 N GLY D 355 52.824 27.117 19.778 1.00 6.36 N

ATOM 11616 CA GLY D 355 53.533 28.127 20.560 1.00 5.75 C

ATOM 11617 C GLY D 355 53.017 28.299 21.971 1.00 5.54 C

ATOM 11618 O GLY D 355 53.743 28.749 22.855 1.00 5.65 O

ATOM 11619 N GLY D 356 51.757 27.937 22.184 1.00 5.43 N

ATOM 11620 CA GLY D 356 51.126 28.071 23.487 1.00 5.05 C

ATOM 11621 C GLY D 356 49.639 28.329 23.355 1.00 4.98 C

ATOM 11622 O GLY D 356 49.019 27.932 22.362 1.00 4.71 O

ATOM 11623 N ALA D 357 49.081 29.010 24.354 1.00 4.88 N

ATOM 11624 CA ALA D 357 47.645 29.254 24.441 1.00 5.11 C

ATOM 11625 CB ALA D 357 47.051 28.460 25.599 1.00 5.21 C

ATOM 11626 C ALA D 357 47.319 30.735 24.602 1.00 5.30 C

ATOM 11627 O ALA D 357 48.094 31.493 25.184 1.00 5.68 O

ATOM 11628 N MET D 358 46.175 31.146 24.065 1.00 5.35 N

ATOM 11629 CA MET D 358 45.619 32.464 24.369 1.00 5.17 C

ATOM 11630 CB MET D 358 45.619 33.398 23.145 1.00 4.93 C

ATOM 11631 CG MET D 358 44.712 32.987 21.989 1.00 6.42 C

ATOM 11632 SD MET D 358 43.029 33.624 22.155 1.00 5.92

ATOM 11633 CE MET D 358 42.546 33.719 20.440 1.00 5.19

ATOM 11634 C MET D 358 44.226 32.315 24.984 1.00 4.81 W2025-7029WO / AM102903-PCT

ATOM 11635 O MET D 358 43.554 31.311 24.775 1.00 4.73 O

ATOM 11636 N VAL D 359 43.810 33.315 25.752 1.00 4.87 N

ATOM 11637 CA VAL D 359 42.587 33.217 26.533 1.00 4.95 C

ATOM 11638 CB VAL D 359 42.883 33.172 28.070 1.00 4.81 C

ATOM 11639 CGl VAL D 359 41.587 33.006 28.871 1.00 4.74 C

ATOM 11640 CG2 VAL D 359 43.870 32.041 28.425 1.00 5.25 C

ATOM 11641 C VAL D 359 41.667 34.399 26.237 1.00 5.02 C

ATOM 11642 O VAL D 359 42.073 35.567 26.366 1.00 4.87 O

ATOM 11643 N TRP D 360 40.434 34.087 25.843 1.00 4.94 N

ATOM 11644 CA TRP D 360 39.354 35.067 25.822 1.00 5.06 C

ATOM 11645 CB TRP D 360 38.728 35.185 24.423 1.00 5.07 C

ATOM 11646 CG TRP D 360 37.766 36.330 24.337 1.00 5.43 C

ATOM 11647 CDl TRP D 360 36.427 36.311 24.637 1.00 5.18 C

ATOM 11648 NEl TRP D 360 35.887 37.565 24.468 1.00 5.15 N

ATOM 11649 CE2 TRP D 360 36.874 38.424 24.063 1.00 5.43 C

ATOM 11650 CD2 TRP D 360 38.076 37.680 23.973 1.00 5.07 C

ATOM 11651 CE3 TRP D 360 39.250 38.333 23.570 1.00 5.99 C

ATOM 11652 CZ3 TRP D 360 39.189 39.697 23.273 1.00 5.20 C

ATOM 11653 CH2 TRP D 360 37.976 40.407 23.373 1.00 5.49 C

ATOM 11654 CZ2 TRP D 360 36.812 39.790 23.763 1.00 5.42 C

ATOM 11655 C TRP D 360 38.287 34.675 26.863 1.00 5.05 C

ATOM 11656 O TRP D 360 37.580 33.688 26.664 1.00 5.09 O

ATOM 11657 N ALA D 361 38.167 35.408 27.977 1.00 5.02 N

ATOM 11658 CA ALA D 361 39.030 36.534 28.359 1.00 4.93 C

ATOM 11659 CB ALA D 361 38.325 37.874 28.079 1.00 4.88 C

ATOM 11660 C ALA D 361 39.370 36.412 29.848 1.00 4.96 C

ATOM 11661 O ALA D 361 38.666 35.722 30.588 1.00 4.79 O

ATOM 11662 N ILE D 362 40.429 37.091 30.296 1.00 5.02 N

ATOM 11663 CA ILE D 362 40.846 37.008 31.711 1.00 4.87 C

ATOM 11664 CB ILE D 362 42.163 37.791 32.003 1.00 4.58 C

ATOM 11665 CGl ILE D 362 42.724 37.407 33.380 1.00 5.64 C

ATOM 11666 CDl ILE D 362 44.241 37.528 33.492 1.00 7.02 C

ATOM 11667 CG2 ILE D 362 41.965 39.310 31.882 1.00 4.56 C

ATOM 11668 C ILE D 362 39.728 37.369 32.700 1.00 4.96 C

ATOM 11669 O ILE D 362 39.623 36.776 33.778 1.00 4.91 O

ATOM 11670 N ASP D 363 38.886 38.321 32.308 1.00 4.98 N

ATOM 11671 CA ASP D 363 37.788 38.803 33.148 1.00 5.31 C

ATOM 11672 CB ASP D 363 37.382 40.218 32.713 1.00 5.30 C

ATOM 11673 CG ASP D 363 37.127 40.323 31.215 1.00 6.12 C

ATOM 11674 ODl ASP D 363 36.073 39.840 30.746 1.00 4.60 O

ATOM 11675 OD2 ASP D 363 37.981 40.903 30.511 1.00 6.78 O

ATOM 11676 C ASP D 363 36.553 37.883 33.208 1.00 5.32 C

ATOM 11677 O ASP D 363 35.597 38.174 33.939 1.00 5.41 O

ATOM 11678 N LEU D 364 36.574 36.783 32.454 1.00 5.24 N

ATOM 11679 CA LEU D 364 35.460 35.815 32.458 1.00 5.29 C

ATOM 11680 CB LEU D 364 35.020 35.479 31.026 1.00 5.15 C

ATOM 11681 CG LEU D 364 34.547 36.661 30.169 1.00 5.17 C

ATOM 11682 CDl LEU D 364 34.448 36.268 28.696 1.00 5.52 C

ATOM 11683 CD2 LEU D 364 33.208 37.219 30.680 1.00 5.72 C

ATOM 11684 C LEU D 364 35.770 34.538 33.263 1.00 5.65 C

ATOM 11685 O LEU D 364 34.870 33.755 33.590 1.00 4.96 O

ATOM 11686 N ASP D 365 37.049 34.339 33.581 1.00 5.67 N

ATOM 11687 CA ASP D 365 37.455 33.307 34.538 1.00 6.11 C

ATOM 11688 CB ASP D 365 38.980 33.177 34.520 1.00 6.04 C

ATOM 11689 CG ASP D 365 39.478 31.860 35.095 1.00 6.48 C

ATOM 11690 ODl ASP D 365 38.664 31.021 35.535 1.00 6.70 O

ATOM 11691 OD2 ASP D 365 40.711 31.665 35.102 1.00 8.25 O

ATOM 11692 C ASP D 365 36.940 33.707 35.932 1.00 6.35 C

ATOM 11693 O ASP D 365 36.579 34.870 36.147 1.00 6.63 O

ATOM 11694 N ASP D 366 36.872 32.754 36.863 1.00 6.55 N

ATOM 11695 CA ASP D 366 36.476 33.058 38.252 1.00 6.81 C

ATOM 11696 CB ASP D 366 36.024 31.788 38.993 1.00 6.76 C

ATOM 11697 CG ASP D 366 35.391 32.078 40.359 1.00 7.11 C W2025-7029WO / AM102903-PCT

ATOM 11698 ODl ASP D 366 34.949 33.218 40.605 1.00 6.92 O

ATOM 11699 OD2 ASP D 366 35.334 31.147 41.196 1.00 8.00 O

ATOM 11700 C ASP D 366 37.619 33.760 38.993 1.00 7.02 C

ATOM 11701 O ASP D 366 38.335 33.152 39.800 1.00 7.36 O

ATOM 11702 N PHE D 367 37.779 35.050 38.719 1.00 7.27 N

ATOM 11703 CA PHE D 367 38.916 35.808 39.234 1.00 7.65 C

ATOM 11704 CB PHE D 367 39.123 37.104 38.440 1.00 7.69 C

ATOM 11705 CG PHE D 367 37.951 38.044 38.473 1.00 7.53 C

ATOM 11706 CDl PHE D 367 36.897 37.899 37.575 1.00 7.81 C

ATOM 11707 CEl PHE D 367 35.812 38.777 37.600 1.00 7.99 C

ATOM 11708 CZ PHE D 367 35.795 39.819 38.520 1.00 7.40 C

ATOM 11709 CE2 PHE D 367 36.850 39.977 39.414 1.00 6.94 C

ATOM 11710 CD2 PHE D 367 37.918 39.095 39.386 1.00 7.34 C

ATOM 11711 C PHE D 367 38.866 36.082 40.742 1.00 8.11 C

ATOM 11712 O PHE D 367 39.914 36.209 41.381 1.00 8.42 O

ATOM 11713 N THR D 368 37.662 36.160 41.305 1.00 8.19 N

ATOM 11714 CA THR D 368 37.505 36.342 42.757 1.00 8.64 C

ATOM 11715 CB THR D 368 36.123 36.940 43.133 1.00 8.40 C

ATOM 11716 OGl THR D 368 35.082 36.006 42.809 1.00 8.00 O

ATOM 11717 CG2 THR D 368 35.879 38.258 42.402 1.00 9.00 C

ATOM 11718 C THR D 368 37.706 35.026 43.519 1.00 8.97 C

ATOM 11719 O THR D 368 38.098 35.030 44.691 1.00 8.97 O

ATOM 11720 N GLY D 369 37.448 33.910 42.837 1.00 9.28 N

ATOM 11721 CA GLY D 369 37.513 32.580 43.436 1.00 9.76 C

ATOM 11722 C GLY D 369 36.269 32.225 44.240 1.00 10.27 C

ATOM 11723 O GLY D 369 36.215 31.163 44.859 1.00 10.44 O

ATOM 11724 N THR D 370 35.264 33.100 44.208 1.00 10.56 N

ATOM 11725 CA THR D 370 34.084 32.975 45.078 1.00 10.90 C

ATOM 11726 CB THR D 370 33.658 34.356 45.673 1.00 10.79 C

ATOM 11727 OGl THR D 370 33.119 35.200 44.648 1.00 11.23 O

ATOM 11728 CG2 THR D 370 34.848 35.053 46.319 1.00 11.51 C

ATOM 11729 C THR D 370 32.877 32.272 44.441 1.00 10.94 C

ATOM 11730 O THR D 370 31.890 31.974 45.128 1.00 10.74 O

ATOM 11731 N PHE D 371 32.954 31.989 43.143 1.00 11.00 N

ATOM 11732 CA PHE D 371 31.842 31.326 42.450 1.00 11.30 C

ATOM 11733 CB PHE D 371 31.601 31.955 41.075 1.00 11.46 C

ATOM 11734 CG PHE D 371 30.968 33.323 41.123 1.00 11.72 C

ATOM 11735 CDl PHE D 371 31.739 34.461 41.360 1.00 11.56 C

ATOM 11736 CEl PHE D 371 31.156 35.733 41.387 1.00 12.02 C

ATOM 11737 CZ PHE D 371 29.784 35.870 41.165 1.00 12.20 C

ATOM 11738 CE2 PHE D 371 29.007 34.735 40.923 1.00 12.59 C

ATOM 11739 CD2 PHE D 371 29.603 33.474 40.897 1.00 12.69 C

ATOM 11740 C PHE D 371 32.009 29.814 42.282 1.00 11.38 C

ATOM 11741 O PHE D 371 31.031 29.080 42.340 1.00 11.37 O

ATOM 11742 N CYS D 372 33.240 29.358 42.059 1.00 11.54 N

ATOM 11743 CA CYS D 372 33.489 27.968 41.652 1.00 11.72 C

ATOM 11744 CB CYS D 372 34.343 27.937 40.378 1.00 11.20 C

ATOM 11745 SG CYS D 372 33.685 28.924 39.027 1.00 9.44

ATOM 11746 C CYS D 372 34.138 27.092 42.730 1.00 12.38 C

ATOM 11747 O CYS D 372 34.192 25.864 42.592 1.00 12.71 O

ATOM 11748 N ASN D 373 34.620 27.730 43.794 1.00 13.27 N

ATOM 11749 CA ASN D 373 35.371 27.061 44.869 1.00 13.82 C

ATOM 11750 CB ASN D 373 34.448 26.186 45.740 1.00 14.62 C

ATOM 11751 CG ASN D 373 33.567 27.010 46.681 1.00 17.06 C

ATOM 11752 ODl ASN D 373 33.967 28.079 47.163 1.00 19.90 O

ATOM 11753 ND2 ASN D 373 32.362 26.509 46.954 1.00 19.80 N

ATOM 11754 C ASN D 373 36.618 26.295 44.384 1.00 13.65 C

ATOM 11755 O ASN D 373 36.987 25.248 44.941 1.00 13.58 O

ATOM 11756 N GLN D 374 37.268 26.843 43.357 1.00 13.02 N

ATOM 11757 CA GLN D 374 38.455 26.236 42.757 1.00 12.65 C

ATOM 11758 CB GLN D 374 38.167 25.820 41.308 1.00 12.63 C

ATOM 11759 CG GLN D 374 37.145 24.700 41.117 1.00 12.54 C

ATOM 11760 CD GLN D 374 36.781 24.492 39.651 1.00 12.34 C W2025-7029WO / AM102903-PCT

ATOM 11761 OEl GLN D 374 36.411 25.434 38.950 1.00 11.58 O

ATOM 11762 NE2 GLN D 374 36.881 23.254 39.186 1.00 11.98 N

ATOM 11763 C GLN D 374 39.664 27.183 42.779 1.00 12.52 C

ATOM 11764 O GLN D 374 40.521 27.112 41.900 1.00 12.97 O

ATOM 11765 N GLY D 375 39.729 28.065 43.776 1.00 12.24 N

ATOM 11766 CA GLY D 375 40.765 29.108 43.838 1.00 11.78 C

ATOM 11767 C GLY D 375 40.543 30.242 42.842 1.00 11.56 C

ATOM 11768 O GLY D 375 39.623 30.187 42.018 1.00 11.58 O

ATOM 11769 N LYS D 376 41.381 31.276 42.911 1.00 10.96 N

ATOM 11770 CA LYS D 376 41.277 32.404 41.987 1.00 10.76 C

ATOM 11771 CB LYS D 376 42.048 33.625 42.500 1.00 10.69 C

ATOM 11772 CG LYS D 376 41.526 34.208 43.817 1.00 11.86 C

ATOM 11773 CD LYS D 376 42.255 35.500 44.174 1.00 12.22 C

ATOM 11774 CE LYS D 376 41.638 36.193 45.385 1.00 14.28 C

ATOM 11775 NZ LYS D 376 42.016 37.643 45.426 1.00 16.15 N

ATOM 11776 C LYS D 376 41.796 31.984 40.618 1.00 9.76 C

ATOM 11777 O LYS D 376 42.767 31.230 40.528 1.00 9.88 O

ATOM 11778 N PHE D 377 41.145 32.474 39.563 1.00 8.93 N

ATOM 11779 CA PHE D 377 41.479 32.110 38.179 1.00 7.90 C

ATOM 11780 CB PHE D 377 42.751 32.835 37.705 1.00 7.82 C

ATOM 11781 CG PHE D 377 42.658 34.338 37.730 1.00 7.41 C

ATOM 11782 CDl PHE D 377 42.037 35.027 36.693 1.00 7.12 C

ATOM 11783 CEl PHE D 377 41.959 36.412 36.699 1.00 6.41 C

ATOM 11784 CZ PHE D 377 42.520 37.129 37.745 1.00 7.67 C

ATOM 11785 CE2 PHE D 377 43.153 36.456 38.788 1.00 7.22 C

ATOM 11786 CD2 PHE D 377 43.225 35.066 38.771 1.00 7.33 C

ATOM 11787 C PHE D 377 41.673 30.597 37.999 1.00 7.49 C

ATOM 11788 O PHE D 377 42.767 30.160 37.631 1.00 7.44 O

ATOM 11789 N PRO D 378 40.627 29.791 38.265 1.00 7.12 N

ATOM 11790 CA PRO D 378 40.808 28.340 38.159 1.00 7.09 C

ATOM 11791 CB PRO D 378 39.432 27.780 38.537 1.00 6.82 C

ATOM 11792 CG PRO D 378 38.477 28.913 38.337 1.00 7.08 C

ATOM 11793 CD PRO D 378 39.254 30.142 38.676 1.00 6.88 C

ATOM 11794 C PRO D 378 41.218 27.880 36.751 1.00 6.97 C

ATOM 11795 O PRO D 378 42.118 27.042 36.620 1.00 6.69 O

ATOM 11796 N LEU D 379 40.583 28.444 35.722 1.00 6.83 N

ATOM 11797 CA LEU D 379 40.855 28.057 34.332 1.00 6.95 C

ATOM 11798 CB LEU D 379 39.766 28.580 33.381 1.00 6.83 C

ATOM 11799 CG LEU D 379 38.331 28.091 33.609 1.00 6.69 C

ATOM 11800 CDl LEU D 379 37.454 28.461 32.420 1.00 6.67 C

ATOM 11801 CD2 LEU D 379 38.284 26.589 33.856 1.00 6.57 C

ATOM 11802 C LEU D 379 42.240 28.460 33.836 1.00 6.78 C

ATOM 11803 O LEU D 379 42.961 27.634 33.292 1.00 6.84 O

ATOM 11804 N ILE D 380 42.599 29.729 34.011 1.00 6.97 N

ATOM 11805 CA ILE D 380 43.903 30.237 33.556 1.00 7.12 C

ATOM 11806 CB ILE D 380 43.923 31.794 33.494 1.00 7.07 C

ATOM 11807 CGl ILE D 380 42.932 32.284 32.424 1.00 7.51 C

ATOM 11808 CDl ILE D 380 42.497 33.750 32.564 1.00 7.09 C

ATOM 11809 CG2 ILE D 380 45.340 32.333 33.181 1.00 6.23 C

ATOM 11810 C ILE D 380 45.072 29.653 34.375 1.00 7.49 C

ATOM 11811 O ILE D 380 46.133 29.345 33.818 1.00 7.15 O

ATOM 11812 N SER D 381 44.861 29.485 35.681 1.00 7.78 N

ATOM 11813 CA SER D 381 45.814 28.771 36.543 1.00 8.52 C

ATOM 11814 CB SER D 381 45.302 28.690 37.986 1.00 8.51 C

ATOM 11815 OG SER D 381 45.235 29.974 38.584 1.00 9.97 O

ATOM 11816 C SER D 381 46.123 27.359 36.027 1.00 8.62 C

ATOM 11817 O SER D 381 47.270 26.909 36.100 1.00 8.60 O

ATOM 11818 N THR D 382 45.101 26.670 35.510 1.00 8.68 N

ATOM 11819 CA THR D 382 45.282 25.334 34.916 1.00 8.82 C

ATOM 11820 CB THR D 382 43.945 24.716 34.419 1.00 8.63 C

ATOM 11821 OGl THR D 382 42.989 24.725 35.481 1.00 8.70 O

ATOM 11822 CG2 THR D 382 44.147 23.277 33.952 1.00 8.99 C

ATOM 11823 C THR D 382 46.266 25.389 33.751 1.00 8.81 C W2025-7029WO / AM102903-PCT

ATOM 11824 O THR D 382 47.139 24.521 33.628 1.00 8.90 O

ATOM 11825 N LEU D 383 46.120 26.413 32.906 1.00 8.73 N

ATOM 11826 CA LEU D 383 46.990 26.590 31.740 1.00 8.96 C

ATOM 11827 CB LEU D 383 46.408 27.628 30.760 1.00 8.78 C

ATOM 11828 CG LEU D 383 45.094 27.273 30.046 1.00 9.19 C

ATOM 11829 CDl LEU D 383 44.682 28.347 29.025 1.00 7.60 C

ATOM 11830 CD2 LEU D 383 45.164 25.894 29.376 1.00 8.34 C

ATOM 11831 C LEU D 383 48.411 26.963 32.140 1.00 9.25 C

ATOM 11832 O LEU D 383 49.370 26.433 31.574 1.00 9.50 O

ATOM 11833 N LYS D 384 48.539 27.865 33.115 1.00 9.46 N

ATOM 11834 CA LYS D 384 49.848 28.302 33.611 1.00 10.26 C

ATOM 11835 CB LYS D 384 49.699 29.371 34.705 1.00 10.01 C

ATOM 11836 CG LYS D 384 50.978 29.594 35.509 1.00 11.05 C

ATOM 11837 CD LYS D 384 50.758 30.483 36.718 1.00 11.80 C

ATOM 11838 CE LYS D 384 51.609 30.036 37.917 1.00 13.81 C

ATOM 11839 NZ LYS D 384 52.959 29.523 37.551 1.00 13.35 N

ATOM 11840 C LYS D 384 50.665 27.123 34.132 1.00 10.08 C

ATOM 11841 O LYS D 384 51.856 27.000 33.829 1.00 9.73 O

ATOM 11842 N LYS D 385 50.007 26.271 34.917 1.00 9.92 N

ATOM 11843 CA LYS D 385 50.619 25.066 35.466 1.00 10.24 C

ATOM 11844 CB LYS D 385 49.706 24.434 36.518 1.00 10.48 C

ATOM 11845 CG LYS D 385 50.427 23.472 37.450 1.00 13.05 C

ATOM 11846 CD LYS D 385 49.468 22.520 38.162 1.00 16.42 C

ATOM 11847 CE LYS D 385 50.227 21.301 38.688 1.00 17.58 C

ATOM 11848 NZ LYS D 385 49.401 20.445 39.578 1.00 18.72 N

ATOM 11849 C LYS D 385 50.964 24.046 34.376 1.00 9.73 C

ATOM 11850 O LYS D 385 52.090 23.563 34.321 1.00 9.64 O

ATOM 11851 N ALA D 386 49.993 23.731 33.515 1.00 9.33 N

ATOM 11852 CA ALA D 386 50.195 22.784 32.415 1.00 8.96 C

ATOM 11853 CB ALA D 386 48.899 22.569 31.646 1.00 9.00 C

ATOM 11854 C ALA D 386 51.305 23.207 31.459 1.00 8.71 C

ATOM 11855 O ALA D 386 52.015 22.359 30.921 1.00 8.71 O

ATOM 11856 N LEU D 387 51.459 24.513 31.257 1.00 8.35 N

ATOM 11857 CA LEU D 387 52.464 25.030 30.329 1.00 8.16 C

ATOM 11858 CB LEU D 387 51.962 26.297 29.616 1.00 7.94 C

ATOM 11859 CG LEU D 387 50.756 26.092 28.686 1.00 7.85 C

ATOM 11860 CDl LEU D 387 50.266 27.427 28.112 1.00 8.12 C

ATOM 11861 CD2 LEU D 387 51.051 25.078 27.573 1.00 7.00 C

ATOM 11862 C LEU D 387 53.830 25.259 30.980 1.00 8.38 C

ATOM 11863 O LEU D 387 54.780 25.656 30.301 1.00 8.45 O

ATOM 11864 N GLY D 388 53.914 25.007 32.286 1.00 8.33 N

ATOM 11865 CA GLY D 388 55.170 25.120 33.036 1.00 8.94 C

ATOM 11866 C GLY D 388 55.770 26.516 33.092 1.00 9.14 C

ATOM 11867 O GLY D 388 56.994 26.679 33.034 1.00 9.04 O

ATOM 11868 N LEU D 389 54.910 27.525 33.207 1.00 9.22 N

ATOM 11869 CA LEU D 389 55.354 28.917 33.250 1.00 9.71 C

ATOM 11870 CB LEU D 389 54.174 29.872 33.073 1.00 9.61 C

ATOM 11871 CG LEU D 389 53.259 29.678 31.864 1.00 9.62 C

ATOM 11872 CDl LEU D 389 52.239 30.779 31.869 1.00 9.87 C

ATOM 11873 CD2 LEU D 389 54.032 29.677 30.542 1.00 8.29 C

ATOM 11874 C LEU D 389 56.105 29.240 34.540 1.00 10.12 C

ATOM 11875 O LEU D 389 55.732 28.771 35.622 1.00 9.62 O

ATOM 11876 N GLN D 390 57.160 30.044 34.398 1.00 10.63 N

ATOM 11877 CA GLN D 390 58.084 30.359 35.484 1.00 11.87 C

ATOM 11878 CB GLN D 390 59.076 29.202 35.651 1.00 11.84 C

ATOM 11879 CG GLN D 390 59.813 29.132 36.987 1.00 14.21 C

ATOM 11880 CD GLN D 390 60.878 28.025 37.009 1.00 14.93 C

ATOM 11881 OEl GLN D 390 60.829 27.070 36.214 1.00 19.50 O

ATOM 11882 NE2 GLN D 390 61.851 28.153 37.917 1.00 17.76 N

ATOM 11883 C GLN D 390 58.845 31.653 35.168 1.00 11.00 C

ATOM 11884 O GLN D 390 59.263 31.868 34.032 1.00 10.83 O

ATOM 11885 N SER D 391 59.023 32.506 36.175 1.00 10.57 N

ATOM 11886 CA SER D 391 59.918 33.660 36.061 1.00 10.20 C W2025-7029WO / AM102903-PCT

ATOM 11887 CB SER D 391 59.197 34.891 35.490 1.00 10.03 C

ATOM 11888 OG SER D 391 58.441 35.570 36.475 1.00 10.32 O

ATOM 11889 C SER D 391 60.556 33.986 37.406 1.00 9.76 C

ATOM 11890 O SER D 391 59.978 33.706 38.456 1.00 9.50 O

ATOM 11891 N ALA D 392 61.750 34.575 37.360 1.00 9.56 N

ATOM 11892 CA ALA D 392 62.456 35.007 38.567 1.00 9.49 C

ATOM 11893 CB ALA D 392 63.819 35.619 38.212 1.00 9.51 C

ATOM 11894 C ALA D 392 61.622 35.973 39.417 1.00 9.71 C

ATOM 11895 O ALA D 392 61.507 35.777 40.625 1.00 9.75 O

ATOM 11896 N SER D 393 61.026 36.990 38.783 1.00 9.88 N

ATOM 11897 CA SER D 393 60.134 37.950 39.466 1.00 10.08 C

ATOM 11898 CB SER D 393 59.437 38.872 38.455 1.00 9.99 C

ATOM 11899 OG SER D 393 60.356 39.675 37.732 1.00 10.65 O

ATOM 11900 C SER D 393 59.058 37.247 40.285 1.00 10.32 C

ATOM 11901 O SER D 393 58.688 37.698 41.375 1.00 10.15 O

ATOM 11902 N CYS D 394 58.565 36.138 39.742 1.00 10.79 N

ATOM 11903 CA CYS D 394 57.447 35.403 40.317 1.00 11.29 C

ATOM 11904 CB CYS D 394 56.565 34.851 39.195 1.00 11.20 C

ATOM 11905 SG CYS D 394 55.767 36.169 38.254 1.00 11.00 S

ATOM 11906 C CYS D 394 57.890 34.313 41.294 1.00 11.63 C

ATOM 11907 O CYS D 394 57.301 33.237 41.353 1.00 12.52 O

ATOM 11908 N THR D 395 58.938 34.609 42.051 1.00 11.96 N

ATOM 11909 CA THR D 395 59.404 33.763 43.145 1.00 11.81 C

ATOM 11910 CB THR D 395 60.833 33.218 42.891 1.00 11.96 C

ATOM 11911 OGl THR D 395 61.764 34.305 42.828 1.00 11.86 O

ATOM 11912 CG2 THR D 395 60.908 32.395 41.590 1.00 11.00 C

ATOM 11913 C THR D 395 59.395 34.618 44.414 1.00 11.91 C

ATOM 11914 O THR D 395 59.182 35.831 44.347 1.00 12.21 O

ATOM 11915 N ALA D 396 59.607 33.987 45.566 1.00 11.75 N

ATOM 11916 CA ALA D 396 59.629 34.702 46.839 1.00 11.74 C

ATOM 11917 CB ALA D 396 58.279 34.580 47.549 1.00 11.68 C

ATOM 11918 C ALA D 396 60.764 34.206 47.737 1.00 11.63 C

ATOM 11919 O ALA D 396 60.546 33.337 48.582 1.00 11.84 O

ATOM 11920 N PRO D 397 61.981 34.764 47.559 1.00 11.55 N

ATOM 11921 CA PRO D 397 63.143 34.401 48.384 1.00 11.41 C

ATOM 11922 CB PRO D 397 64.286 35.219 47.766 1.00 11.28 C

ATOM 11923 CG PRO D 397 63.794 35.632 46.413 1.00 11.46 C

ATOM 11924 CD PRO D 397 62.324 35.795 46.564 1.00 11.32 C

ATOM 11925 C PRO D 397 62.955 34.797 49.853 1.00 11.51 C

ATOM 11926 O PRO D 397 62.025 35.545 50.178 1.00 11.35 O

ATOM 11927 N ALA D 398 63.834 34.298 50.724 1.00 11.75 N

ATOM 11928 CA ALA D 398 63.814 34.646 52.152 1.00 12.02 C

ATOM 11929 CB ALA D 398 64.534 33.587 52.980 1.00 11.85 C

ATOM 11930 C ALA D 398 64.395 36.044 52.407 1.00 12.27 C

ATOM 11931 O ALA D 398 65.442 36.207 53.045 1.00 11.92 O

ATOM 11932 N GLN D 399 63.690 37.040 51.878 1.00 12.75 N

ATOM 11933 CA GLN D 399 63.984 38.455 52.056 1.00 13.11 C

ATOM 11934 CB GLN D 399 64.782 38.988 50.864 1.00 12.87 C

ATOM 11935 CG GLN D 399 66.212 38.448 50.781 1.00 12.30 C

ATOM 11936 CD GLN D 399 66.936 38.842 49.507 1.00 12.29 C

ATOM 11937 OEl GLN D 399 67.428 37.985 48.769 1.00 11.56 O

ATOM 11938 NE2 GLN D 399 67.010 40.137 49.245 1.00 9.84 N

ATOM 11939 C GLN D 399 62.630 39.165 52.172 1.00 14.10 C

ATOM 11940 O GLN D 399 61.664 38.735 51.541 1.00 14.54 O

ATOM 11941 N PRO D 400 62.548 40.245 52.977 1.00 14.91 N

ATOM 11942 CA PRO D 400 61.273 40.920 53.273 1.00 15.36 C

ATOM 11943 CB PRO D 400 61.691 42.085 54.177 1.00 15.58 C

ATOM 11944 CG PRO D 400 62.991 41.678 54.746 1.00 15.69 C

ATOM 11945 CD PRO D 400 63.674 40.906 53.657 1.00 15.27 C

ATOM 11946 C PRO D 400 60.575 41.470 52.031 1.00 15.65 C

ATOM 11947 O PRO D 400 61.233 42.039 51.159 1.00 16.06 O W2025-7029WO / AM102903-PCT

Table 2. X-ray crystallographically determined structural coordinates of two methylallosimidin-bound human AMCase polypeptides (SEQ ID NOs X-Y respectively). # Name Res. /Chain/Res # X Y Z Occ. B Element

ATOM 1 N TYR A 22 11.257 50.960 90.536 1.00 11.24 N

ATOM 2 CA TYR A 22 10.344 50.669 89.382 1.00 11.06 C

ATOM 3 CB TYR A 22 9.021 51.425 89.546 1.00 11.22 C

ATOM 4 CG TYR A 22 8.278 51.068 90.812 1.00 10.76 C

ATOM 5 CDl TYR A 22 8.331 51.899 91.931 1.00 10.83 C

ATOM 6 CEl TYR A 22 7.663 51.566 93.104 1.00 10.77 C

ATOM 7 CZ TYR A 22 6.936 50.387 93.166 1.00 11.20 C

ATOM 8 OH TYR A 22 6.269 50.060 94.326 1.00 12.03 O

ATOM 9 CE2 TYR A 22 6.866 49.540 92.065 1.00 11.50 C

ATOM 10 CD2 TYR A 22 7.541 49.881 90.900 1.00 11.69 C

ATOM 11 C TYR A 22 10.982 51.033 88.043 1.00 11.34 C

ATOM 12 O TYR A 22 11.789 51.962 87.971 1.00 11.78 O

ATOM 13 N GLN A 23 10.620 50.291 86.995 1.00 11.13 N

ATOM 14 CA GLN A 23 10.997 50.648 85.627 1.00 11.19 C

ATOM 15 CB GLN A 23 11.179 49.398 84.739 1.00 12.13 C

ATOM 16 CG GLN A 23 12.242 48.377 85.207 1.00 14.06 C

ATOM 17 CD GLN A 23 13.653 48.959 85.332 1.00 17.96 C

ATOM 18 OEl GLN A 23 13.950 50.043 84.819 1.00 19.79 O

ATOM 19 NE2 GLN A 23 14.528 48.229 86.014 1.00 19.07 N

ATOM 20 C GLN A 23 9.905 51.530 85.034 1.00 10.73 C

ATOM 21 O GLN A 23 8.722 51.378 85.363 1.00 10.39 O

ATOM 22 N LEU A 24 10.315 52.465 84.180 1.00 9.90 N

ATOM 23 CA LEU A 24 9.391 53.208 83.339 1.00 9.48 C

ATOM 24 CB LEU A 24 9.285 54.679 83.760 1.00 9.46 C

ATOM 25 CG LEU A 24 8.369 55.582 82.920 1.00 9.13 C

ATOM 26 CDl LEU A 24 6.936 55.045 82.797 1.00 10.42 C

ATOM 27 CD2 LEU A 24 8.363 57.012 83.462 1.00 9.59 C

ATOM 28 C LEU A 24 9.888 53.060 81.910 1.00 9.51 C

ATOM 29 O LEU A 24 10.868 53.691 81.508 1.00 9.39 O

ATOM 30 N THR A 25 9.206 52.192 81.170 1.00 9.31 N

ATOM 31 CA THR A 25 9.644 51.749 79.856 1.00 9.06 C

ATOM 32 CB THR A 25 9.613 50.212 79.795 1.00 9.44 C

ATOM 33 OGl THR A 25 10.590 49.699 80.707 1.00 9.46 O

ATOM 34 CG2 THR A 25 9.914 49.694 78.383 1.00 8.81 C

ATOM 35 C THR A 25 8.749 52.366 78.787 1.00 9.35 C

ATOM 36 O THR A 25 7.540 52.200 78.818 1.00 9.71 O

ATOM 37 N CYS A 26 9.351 53.080 77.842 1.00 8.78 N

ATOM 38 CA CYS A 26 8.572 53.853 76.880 1.00 9.12 C

ATOM 39 CB CYS A 26 8.873 55.341 77.048 1.00 9.18 C

ATOM 40 SG CYS A 26 8.628 55.916 78.742 1.00 11.08 S

ATOM 41 C CYS A 26 8.864 53.430 75.456 1.00 8.77 C

ATOM 42 O CYS A 26 10.027 53.369 75.053 1.00 8.87 O

ATOM 43 N TYR A 27 7.806 53.148 74.698 1.00 8.44 N

ATOM 44 CA TYR A 27 7.953 52.752 73.296 1.00 8.22 C

ATOM 45 CB TYR A 27 6.845 51.782 72.875 1.00 7.93 C

ATOM 46 CG TYR A 27 6.983 50.386 73.440 1.00 8.05 C

ATOM 47 CDl TYR A 27 7.589 49.367 72.699 1.00 6.38 C

ATOM 48 CEl TYR A 27 7.711 48.076 73.214 1.00 7.09 C

ATOM 49 CZ TYR A 27 7.214 47.796 74.480 1.00 7.24 C

ATOM 50 OH TYR A 27 7.322 46.534 74.997 1.00 8.52 O

ATOM 51 CE2 TYR A 27 6.607 48.791 75.232 1.00 8.25 C

ATOM 52 CD2 TYR A 27 6.489 50.076 74.705 1.00 7.71 C

ATOM 53 C TYR A 27 7.955 53.947 72.355 1.00 8.13 C

ATOM 54 O TYR A 27 7.095 54.828 72.455 1.00 7.92 O

ATOM 55 N PHE A 28 8.932 53.951 71.449 1.00 8.03 N W2025-7029WO / AM102903-PCT

ATOM 56 CA PHE A 28 9.025 54.909 70.348 1.00 8.32 C

ATOM 57 CB PHE A 28 10.433 55.508 70.281 1.00 8.40 C

ATOM 58 CG PHE A 28 10.771 56.133 68.950 1.00 8.89 C

ATOM 59 CDl PHE A 28 10.374 57.436 68.654 1.00 9.00 C

ATOM 60 CEl PHE A 28 10.682 58.011 67.424 1.00 9.58 C

ATOM 61 CZ PHE A 28 11.402 57.277 66.474 1.00 9.32 C

ATOM 62 CE2 PHE A 28 11.807 55.978 66.760 1.00 10.07 C

ATOM 63 CD2 PHE A 28 11.497 55.416 67.995 1.00 9.65 C

ATOM 64 C PHE A 28 8.699 54.188 69.042 1.00 8.20 C

ATOM 65 O PHE A 28 9.134 53.058 68.826 1.00 9.08 O

ATOM 66 N THR A 29 7.946 54.847 68.165 1.00 8.15 N

ATOM 67 CA THR A 29 7.513 54.203 66.921 1.00 8.00 C

ATOM 68 CB THR A 29 5.982 54.172 66.794 1.00 8.37 C

ATOM 69 OGl THR A 29 5.482 55.504 66.645 1.00 7.90 O

ATOM 70 CG2 THR A 29 5.351 53.523 68.041 1.00 8.17 C

ATOM 71 C THR A 29 8.127 54.865 65.699 1.00 8.22 C

ATOM 72 O THR A 29 8.143 56.102 65.599 1.00 8.10 O

ATOM 73 N ASN A 30 8.637 54.048 64.775 1.00 8.16 N

ATOM 74 CA ASN A 30 9.342 54.580 63.597 1.00 8.35 C

ATOM 75 CB ASN A 30 10.396 53.588 63.069 1.00 8.27 C

ATOM 76 CG ASN A 30 9.792 52.302 62.515 1.00 8.65 C

ATOM 77 ODl ASN A 30 8.578 52.096 62.544 1.00 8.34 O

ATOM 78 ND2 ASN A 30 10.656 51.422 62.004 1.00 9.10 N

ATOM 79 C ASN A 30 8.461 55.134 62.462 1.00 8.26 C

ATOM 80 O ASN A 30 8.972 55.480 61.393 1.00 8.58 O

ATOM 81 N TRP A 31 7.152 55.199 62.696 1.00 8.42 N

ATOM 82 CA TRP A 31 6.218 55.815 61.747 1.00 8.59 C

ATOM 83 CB TRP A 31 5.054 54.869 61.415 1.00 8.35 C

ATOM 84 CG TRP A 31 4.230 54.432 62.601 1.00 8.09 C

ATOM 85 CDl TRP A 31 3.096 55.025 63.084 1.00 8.32 C

ATOM 86 NEl TRP A 31 2.618 54.326 64.177 1.00 7.65 N

ATOM 87 CE2 TRP A 31 3.448 53.259 64.412 1.00 8.26 C

ATOM 88 CD2 TRP A 31 4.472 53.291 63.432 1.00 7.77 C

ATOM 89 CE3 TRP A 31 5.461 52.295 63.449 1.00 8.55 C

ATOM 90 CZ3 TRP A 31 5.396 51.304 64.430 1.00 7.97 C

ATOM 91 CH2 TRP A 31 4.362 51.300 65.390 1.00 9.06 C

ATOM 92 CZ2 TRP A 31 3.383 52.265 65.397 1.00 8.15 C

ATOM 93 C TRP A 31 5.695 57.179 62.214 1.00 8.71 C

ATOM 94 O TRP A 31 5.038 57.888 61.454 1.00 9.11 O

ATOM 95 N ALA A 32 6.010 57.552 63.455 1.00 9.06 N

ATOM 96 CA ALA A 32 5.638 58.866 63.990 1.00 9.05 C

ATOM 97 CB ALA A 32 6.017 58.962 65.469 1.00 9.34 C

ATOM 98 C ALA A 32 6.289 60.002 63.194 1.00 9.02 C

ATOM 99 O ALA A 32 5.795 61.127 63.184 1.00 9.11 O

ATOM 100 N GLN A 33 7.389 59.680 62.521 1.00 8.96 N

ATOM 101 CA GLN A 33 8.134 60.633 61.694 1.00 9.33 C

ATOM 102 CB GLN A 33 9.411 59.974 61.162 1.00 9.36 C

ATOM 103 CG GLN A 33 9.168 58.780 60.254 1.00 9.28 C

ATOM 104 CD GLN A 33 10.419 58.318 59.543 1.00 9.88 C

ATOM 105 OEl GLN A 33 11.140 59.120 58.943 1.00 9.88 O

ATOM 106 NE2 GLN A 33 10.678 57.019 59.592 1.00 8.52 N

ATOM 107 C GLN A 33 7.321 61.192 60.519 1.00 9.44 C

ATOM 108 O GLN A 33 7.671 62.246 59.972 1.00 9.48 O

ATOM 109 N TYR A 34 6.255 60.484 60.132 1.00 9.69 N

ATOM 110 CA TYR A 34 5.455 60.860 58.959 1.00 10.04 C

ATOM 111 CB TYR A 34 5.029 59.616 58.171 1.00 10.13 C

ATOM 112 CG TYR A 34 6.203 58.788 57.716 1.00 9.91 C

ATOM 113 CDl TYR A 34 7.191 59.346 56.905 1.00 10.81 C

ATOM 114 CEl TYR A 34 8.279 58.607 56.487 1.00 10.02 C

ATOM 115 CZ TYR A 34 8.393 57.279 56.876 1.00 11.39 C

ATOM 116 OH TYR A 34 9.473 56.549 56.450 1.00 11.13 O

ATOM 117 CE2 TYR A 34 7.426 56.697 57.682 1.00 10.82 C

ATOM 118 CD2 TYR A 34 6.338 57.456 58.103 1.00 10.74 C W2025-7029WO / AM102903-PCT

ATOM 119 C TYR A 34 4.243 61.731 59.261 1.00 10.62 C

ATOM 120 O TYR A 34 3.523 62.138 58.344 1.00 11.05 O

ATOM 121 N ARG A 35 4.032 62.024 60.540 1.00 11.05 N

ATOM 122 CA ARG A 35 2.880 62.817 60.960 1.00 11.00 C

ATOM 123 CB ARG A 35 2.616 62.625 62.457 1.00 11.00 C

ATOM 124 CG ARG A 35 2.253 61.191 62.793 1.00 10.64 C

ATOM 125 CD ARG A 35 2.040 60.945 64.273 1.00 9.94 C

ATOM 126 NE ARG A 35 1.728 59.531 64.471 1.00 9.70 N

ATOM 127 CZ ARG A 35 2.074 58.808 65.533 1.00 8.68 C

ATOM 128 NHl ARG A 35 2.753 59.353 66.536 1.00 7.80 N

ATOM 129 NH2 ARG A 35 1.743 57.520 65.581 1.00 8.42 N

ATOM 130 C ARG A 35 3.103 64.287 60.607 1.00 11.28 C

ATOM 131 O ARG A 35 4.238 64.767 60.664 1.00 11.05 O

ATOM 132 N PRO A 36 2.024 64.997 60.220 1.00 11.53 N

ATOM 133 CA PRO A 36 2.162 66.386 59.789 1.00 11.59 C

ATOM 134 CB PRO A 36 0.792 66.696 59.179 1.00 11.84 C

ATOM 135 CG PRO A 36 -0.156 65.808 59.938 1.00 11.85 C

ATOM 136 CD PRO A 36 0.623 64.535 60.149 1.00 11.53 C

ATOM 137 C PRO A 36 2.442 67.352 60.935 1.00 11.74 C

ATOM 138 O PRO A 36 2.008 67.118 62.068 1.00 11.71 O

ATOM 139 N GLY A 37 3.168 68.427 60.632 1.00 11.55 N

ATOM 140 CA GLY A 37 3.312 69.548 61.563 1.00 11.48 C

ATOM 141 C GLY A 37 3.764 69.133 62.949 1.00 11.13 C

ATOM 142 O GLY A 37 4.754 68.422 63.090 1.00 11.14 O

ATOM 143 N LEU A 38 3.024 69.571 63.969 1.00 11.38 N

ATOM 144 CA LEU A 38 3.372 69.317 65.378 1.00 11.48 C

ATOM 145 CB LEU A 38 2.474 70.151 66.308 1.00 12.03 C

ATOM 146 CG LEU A 38 2.647 71.675 66.269 1.00 13.12 C

ATOM 147 CDl LEU A 38 1.491 72.375 66.977 1.00 14.79 C

ATOM 148 CD2 LEU A 38 3.986 72.085 66.880 1.00 13.75 C

ATOM 149 C LEU A 38 3.327 67.843 65.802 1.00 11.51 C

ATOM 150 O LEU A 38 3.803 67.489 66.889 1.00 11.42 O

ATOM 151 N GLY A 39 2.750 66.992 64.956 1.00 10.85 N

ATOM 152 CA GLY A 39 2.675 65.558 65.245 1.00 11.07 C

ATOM 153 C GLY A 39 3.977 64.825 64.958 1.00 11.03 C

ATOM 154 O GLY A 39 4.253 63.773 65.540 1.00 10.59 O

ATOM 155 N ARG A 40 4.787 65.382 64.058 1.00 11.22 N

ATOM 156 CA ARG A 40 6.053 64.755 63.693 1.00 11.68 C

ATOM 157 CB ARG A 40 6.805 65.606 62.664 1.00 11.67 C

ATOM 158 CG ARG A 40 8.086 64.959 62.137 1.00 14.11 C

ATOM 159 CD ARG A 40 8.633 65.750 60.950 1.00 16.63 C

ATOM 160 NE ARG A 40 10.076 65.581 60.774 1.00 19.14 N

ATOM 161 CZ ARG A 40 10.640 64.627 60.040 1.00 19.40 C

ATOM 162 NHl ARG A 40 11.960 64.563 59.941 1.00 19.52 N

ATOM 163 NH2 ARG A 40 9.891 63.736 59.403 1.00 20.02 N

ATOM 164 C ARG A 40 6.911 64.511 64.935 1.00 11.31 C

ATOM 165 O ARG A 40 7.169 65.427 65.726 1.00 11.51 O

ATOM 166 N PHE A 41 7.328 63.261 65.112 1.00 11.19 N

ATOM 167 CA PHE A 41 8.117 62.878 66.271 1.00 10.88 C

ATOM 168 CB PHE A 41 7.242 62.169 67.319 1.00 10.54 C

ATOM 169 CG PHE A 41 7.915 61.996 68.659 1.00 10.39 C

ATOM 170 CDl PHE A 41 7.644 62.871 69.705 1.00 9.89 C

ATOM 171 CEl PHE A 41 8.262 62.718 70.951 1.00 9.74 C

ATOM 172 CZ PHE A 41 9.167 61.684 71.153 1.00 10.07 C

ATOM 173 CE2 PHE A 41 9.450 60.800 70.112 1.00 9.38 C

ATOM 174 CD2 PHE A 41 8.826 60.960 68.875 1.00 10.12 C

ATOM 175 C PHE A 41 9.297 62.004 65.865 1.00 10.92 C

ATOM 176 O PHE A 41 9.123 60.936 65.263 1.00 11.10 O

ATOM 177 N MET A 42 10.491 62.481 66.211 1.00 11.05 N

ATOM 178 CA MET A 42 11.764 61.835 65.889 1.00 11.30 C

ATOM 179 CB MET A 42 12.663 62.813 65.110 1.00 11.54 C

ATOM 180 CG MET A 42 12.009 63.446 63.889 1.00 11.99 C

ATOM 181 SD MET A 42 11.475 62.236 62.660 1.00 15.00 S W2025-7029WO / AM102903-PCT

ATOM 182 CE MET A 42 13.040 61.736 61.953 1.00 14.65 C

ATOM 183 C MET A 42 12.463 61.406 67.182 1.00 11.38 C

ATOM 184 O MET A 42 12.091 61.873 68.264 1.00 11.64 O

ATOM 185 N PRO A 43 13.480 60.521 67.086 1.00 11.38 N

ATOM 186 CA PRO A 43 14.203 60.099 68.293 1.00 11.36 C

ATOM 187 CB PRO A 43 15.362 59.268 67.740 1.00 11.47 C

ATOM 188 CG PRO A 43 14.853 58.740 66.442 1.00 11.29 C

ATOM 189 CD PRO A 43 13.982 59.832 65.878 1.00 11.28 C

ATOM 190 C PRO A 43 14.729 61.254 69.159 1.00 11.66 C

ATOM 191 O PRO A 43 14.682 61.159 70.384 1.00 11.90 O

ATOM 192 N ASP A 44 15.201 62.333 68.533 1.00 12.24 N

ATOM 193 CA ASP A 44 15.756 63.471 69.284 1.00 13.20 C

ATOM 194 CB ASP A 44 16.645 64.340 68.383 1.00 13.80 C

ATOM 195 CG ASP A 44 17.973 63.670 68.061 1.00 15.07 C

ATOM 196 ODl ASP A 44 18.746 63.375 68.997 1.00 17.51 O

ATOM 197 OD2 ASP A 44 18.242 63.434 66.867 1.00 17.52 O

ATOM 198 C ASP A 44 14.687 64.309 70.007 1.00 13.00 C

ATOM 199 O ASP A 44 15.010 65.230 70.758 1.00 13.37 O

ATOM 200 N ASP A 45 13.417 63.979 69.781 1.00 12.92 N

ATOM 201 CA ASP A 45 12.321 64.613 70.507 1.00 12.70 C

ATOM 202 CB ASP A 45 11.049 64.631 69.658 1.00 13.21 C

ATOM 203 CG ASP A 45 11.197 65.483 68.421 1.00 13.86 C

ATOM 204 ODl ASP A 45 11.684 66.628 68.542 1.00 13.87 O

ATOM 205 OD2 ASP A 45 10.836 65.007 67.328 1.00 15.99 O

ATOM 206 C ASP A 45 12.066 63.937 71.856 1.00 12.54 C

ATOM 207 O ASP A 45 11.294 64.441 72.668 1.00 12.71 O

ATOM 208 N ILE A 46 12.733 62.808 72.088 1.00 12.15 N

ATOM 209 CA ILE A 46 12.620 62.081 73.348 1.00 11.66 C

ATOM 210 CB ILE A 46 13.066 60.599 73.205 1.00 11.79 C

ATOM 211 CGl ILE A 46 12.125 59.828 72.267 1.00 10.55 C

ATOM 212 CDl ILE A 46 12.654 58.447 71.846 1.00 10.86 C

ATOM 213 CG2 ILE A 46 13.153 59.923 74.575 1.00 11.25 C

ATOM 214 C ILE A 46 13.477 62.763 74.413 1.00 11.91 C

ATOM 215 O ILE A 46 14.668 62.995 74.199 1.00 11.91 O

ATOM 216 N ASN A 47 12.861 63.084 75.549 1.00 11.98 N

ATOM 217 CA ASN A 47 13.601 63.515 76.729 1.00 12.73 C

ATOM 218 CB ASN A 47 12.652 64.117 77.772 1.00 12.64 C

ATOM 219 CG ASN A 47 13.374 64.611 79.020 1.00 13.23 C

ATOM 220 ODl ASN A 47 14.517 64.235 79.294 1.00 13.35 O

ATOM 221 ND2 ASN A 47 12.691 65.451 79.795 1.00 14.54 N

ATOM 222 C ASN A 47 14.337 62.298 77.296 1.00 13.07 C

ATOM 223 O ASN A 47 13.697 61.367 77.786 1.00 12.70 O

ATOM 224 N PRO A 48 15.685 62.303 77.231 1.00 13.77 N

ATOM 225 CA PRO A 48 16.468 61.139 77.664 1.00 14.58 C

ATOM 226 CB PRO A 48 17.906 61.520 77.294 1.00 14.65 C

ATOM 227 CG PRO A 48 17.907 63.000 77.211 1.00 14.33 C

ATOM 228 CD PRO A 48 16.547 63.400 76.748 1.00 13.77 C

ATOM 229 C PRO A 48 16.359 60.827 79.164 1.00 15.54 C

ATOM 230 O PRO A 48 16.780 59.750 79.598 1.00 15.57 O

ATOM 231 N CYS A 49 15.780 61.757 79.924 1.00 16.32 N

ATOM 232 CA CYS A 49 15.678 61.656 81.380 1.00 17.53 C

ATOM 233 CB CYS A 49 16.043 62.999 82.010 1.00 18.55 C

ATOM 234 SG CYS A 49 17.748 63.464 81.678 1.00 25.27 S

ATOM 235 C CYS A 49 14.296 61.227 81.862 1.00 16.41 C

ATOM 236 O CYS A 49 14.068 61.085 83.067 1.00 16.46 O

ATOM 237 N LEU A 50 13.383 61.016 80.919 1.00 15.33 N

ATOM 238 CA LEU A 50 11.980 60.774 81.237 1.00 14.52 C

ATOM 239 CB LEU A 50 11.111 61.170 80.043 1.00 14.94 C

ATOM 240 CG LEU A 50 9.589 61.062 80.138 1.00 15.41 C

ATOM 241 CDl LEU A 50 9.004 62.049 81.152 1.00 16.48 C

ATOM 242 CD2 LEU A 50 8.976 61.282 78.755 1.00 15.35 C

ATOM 243 C LEU A 50 11.702 59.328 81.648 1.00 13.67 C

ATOM 244 O LEU A 50 11.012 59.081 82.643 1.00 13.55 O W2025-7029WO / AM102903-PCT

ATOM 245 N CYS A 51 12.242 58.388 80.877 1.00 12.60 N

ATOM 246 CA CYS A 51 12.017 56.957 81.090 1.00 12.22 C

ATOM 247 CB CYS A 51 11.443 56.325 79.819 1.00 12.07 C

ATOM 248 SG CYS A 51 10.113 57.265 79.061 1.00 13.41 S

ATOM 249 C CYS A 51 13.317 56.252 81.466 1.00 11.70 C

ATOM 250 O CYS A 51 14.405 56.765 81.193 1.00 12.05 O

ATOM 251 N THR A 52 13.198 55.079 82.084 1.00 10.89 N

ATOM 252 CA THR A 52 14.362 54.256 82.430 1.00 10.62 C

ATOM 253 CB THR A 52 14.080 53.332 83.637 1.00 10.71 C

ATOM 254 OGl THR A 52 12.979 52.464 83.335 1.00 10.86 O

ATOM 255 CG2 THR A 52 13.771 54.146 84.886 1.00 10.97 C

ATOM 256 C THR A 52 14.807 53.403 81.247 1.00 10.25 C

ATOM 257 O THR A 52 16.001 53.128 81.072 1.00 10.43 O

ATOM 258 N HIS A 53 13.832 52.976 80.446 1.00 9.74 N

ATOM 259 CA HIS A 53 14.079 52.151 79.267 1.00 9.14 C

ATOM 260 CB HIS A 53 13.613 50.714 79.516 1.00 9.52 C

ATOM 261 CG HIS A 53 14.419 49.994 80.551 1.00 11.08 C

ATOM 262 NDl HIS A 53 14.400 50.344 81.886 1.00 14.09 N

ATOM 263 CEl HIS A 53 15.215 49.544 82.555 1.00 14.73 C

ATOM 264 NE2 HIS A 53 15.754 48.690 81.707 1.00 12.90 N

ATOM 265 CD2 HIS A 53 15.274 48.950 80.446 1.00 13.23 C

ATOM 266 C HIS A 53 13.318 52.727 78.086 1.00 8.60 C

ATOM 267 O HIS A 53 12.198 53.199 78.250 1.00 8.56 O

ATOM 268 N LEU A 54 13.939 52.708 76.912 1.00 8.15 N

ATOM 269 CA LEU A 54 13.264 53.094 75.678 1.00 8.08 C

ATOM 270 CB LEU A 54 13.958 54.295 75.027 1.00 8.34 C

ATOM 271 CG LEU A 54 14.004 55.601 75.821 1.00 8.60 C

ATOM 272 CDl LEU A 54 14.917 56.580 75.099 1.00 9.56 C

ATOM 273 CD2 LEU A 54 12.618 56.201 76.035 1.00 9.42 C

ATOM 274 C LEU A 54 13.280 51.919 74.725 1.00 8.07 C

ATOM 275 O LEU A 54 14.315 51.272 74.557 1.00 8.17 O

ATOM 276 N ILE A 55 12.136 51.642 74.104 1.00 7.55 N

ATOM 277 CA ILE A 55 12.040 50.519 73.177 1.00 7.66 C

ATOM 278 CB ILE A 55 11.125 49.381 73.719 1.00 7.42 C

ATOM 279 CGl ILE A 55 11.609 48.921 75.106 1.00 7.71 C

ATOM 280 CDl ILE A 55 10.901 47.690 75.656 1.00 8.04 C

ATOM 281 CG2 ILE A 55 11.096 48.202 72.742 1.00 7.80 C

ATOM 282 C ILE A 55 11.600 50.992 71.792 1.00 7.70 C

ATOM 283 O ILE A 55 10.624 51.730 71.654 1.00 7.60 O

ATOM 284 N TYR A 56 12.355 50.563 70.784 1.00 7.82 N

ATOM 285 CA TYR A 56 12.176 50.979 69.398 1.00 8.10 C

ATOM 286 CB TYR A 56 13.546 51.007 68.723 1.00 8.08 C

ATOM 287 CG TYR A 56 13.600 51.699 67.384 1.00 8.40 C

ATOM 288 CDl TYR A 56 14.173 52.965 67.262 1.00 9.23 C

ATOM 289 CEl TYR A 56 14.248 53.608 66.032 1.00 8.90 C

ATOM 290 CZ TYR A 56 13.747 52.984 64.900 1.00 8.75 C

ATOM 291 OH TYR A 56 13.819 53.624 63.687 1.00 8.97 O

ATOM 292 CE2 TYR A 56 13.173 51.722 64.983 1.00 8.78 C

ATOM 293 CD2 TYR A 56 13.107 51.081 66.228 1.00 8.45 C

ATOM 294 C TYR A 56 11.248 50.013 68.653 1.00 8.21 C

ATOM 295 O TYR A 56 11.570 48.836 68.485 1.00 8.73 O

ATOM 296 N ALA A 57 10.112 50.527 68.192 1.00 8.05 N

ATOM 297 CA ALA A 57 9.143 49.746 67.418 1.00 7.84 C

ATOM 298 CB ALA A 57 7.761 49.898 68.038 1.00 8.03 C

ATOM 299 C ALA A 57 9.124 50.231 65.962 1.00 7.91 C

ATOM 300 O ALA A 57 8.881 51.419 65.728 1.00 7.63 O

ATOM 301 N PHE A 58 9.367 49.356 64.972 1.00 7.84 N

ATOM 302 CA PHE A 58 9.624 47.919 65.127 1.00 7.90 C

ATOM 303 CB PHE A 58 8.389 47.101 64.719 1.00 8.03 C

ATOM 304 CG PHE A 58 7.283 47.093 65.733 1.00 7.34 C

ATOM 305 CDl PHE A 58 6.057 47.690 65.437 1.00 7.55 C

ATOM 306 CEl PHE A 58 5.014 47.686 66.370 1.00 7.09 C

ATOM 307 CZ PHE A 58 5.200 47.071 67.612 1.00 7.23 C W2025-7029WO / AM102903-PCT

ATOM 308 CE2 PHE A 58 6.424 46.465 67.913 1.00 7.67 C

ATOM 309 CD2 PHE A 58 7.456 46.479 66.973 1.00 7.53 C

ATOM 310 C PHE A 58 10.737 47.480 64.177 1.00 7.77 C

ATOM 311 O PHE A 58 10.976 48.131 63.151 1.00 7.56 O

ATOM 312 N ALA A 59 11.390 46.370 64.513 1.00 7.99 N

ATOM 313 CA ALA A 59 12.197 45.603 63.562 1.00 8.42 C

ATOM 314 CB ALA A 59 13.363 44.935 64.274 1.00 8.46 C

ATOM 315 C ALA A 59 11.326 44.548 62.874 1.00 8.70 C

ATOM 316 O ALA A 59 10.267 44.182 63.389 1.00 8.53 O

ATOM 317 N GLY A 60 11.778 44.065 61.716 1.00 8.90 N

ATOM 318 CA GLY A 60 11.087 43.008 60.979 1.00 9.64 C

ATOM 319 C GLY A 60 11.937 41.754 60.863 1.00 10.20 C

ATOM 320 O GLY A 60 12.868 41.547 61.647 1.00 10.48 O

ATOM 321 N MET A 61 11.615 40.911 59.886 1.00 10.59 N

ATOM 322 CA MET A 61 12.350 39.666 59.676 1.00 11.35 C

ATOM 323 CB MET A 61 11.715 38.526 60.482 1.00 11.28 C

ATOM 324 CG MET A 61 12.632 37.315 60.737 1.00 11.70 C

ATOM 325 SD MET A 61 11.762 35.885 61.420 1.00 12.50

ATOM 326 CE MET A 61 11.107 36.578 62.941 1.00 11.66 C

ATOM 327 C MET A 61 12.388 39.293 58.201 1.00 12.08 C

ATOM 328 O MET A 61 11.397 39.447 57.485 1.00 12.13 O

ATOM 329 N GLN A 62 13.543 38.811 57.759 1.00 12.33 N

ATOM 330 CA GLN A 62 13.705 38.309 56.402 1.00 13.11 C

ATOM 331 CB GLN A 62 14.228 39.402 55.468 1.00 13.67 C

ATOM 332 CG GLN A 62 14.305 39.000 53.994 1.00 17.49 C

ATOM 333 CD GLN A 62 12.940 38.873 53.331 1.00 21.54 C

ATOM 334 OEl GLN A 62 12.001 39.605 53.656 1.00 25.13 O

ATOM 335 NE2 GLN A 62 12.829 37.941 52.383 1.00 24.66 N

ATOM 336 C GLN A 62 14.662 37.131 56.436 1.00 12.89 C

ATOM 337 O GLN A 62 15.755 37.227 56.999 1.00 12.46 O

ATOM 338 N ASN A 63 14.236 36.019 55.840 1.00 12.69 N

ATOM 339 CA ASN A 63 15.025 34.782 55.834 1.00 13.02 C

ATOM 340 CB ASN A 63 16.158 34.875 54.802 1.00 13.64 C

ATOM 341 CG ASN A 63 15.637 35.095 53.383 1.00 15.30 C

ATOM 342 ODl ASN A 63 14.681 34.447 52.950 1.00 18.52 O

ATOM 343 ND2 ASN A 63 16.267 36.010 52.657 1.00 16.86 N

ATOM 344 C ASN A 63 15.535 34.401 57.232 1.00 12.65 C

ATOM 345 O ASN A 63 16.709 34.072 57.425 1.00 12.04 O

ATOM 346 N ASN A 64 14.620 34.474 58.199 1.00 12.32 N

ATOM 347 CA ASN A 64 14.865 34.109 59.599 1.00 11.96 C

ATOM 348 CB ASN A 64 15.214 32.621 59.726 1.00 11.98 C

ATOM 349 CG ASN A 64 14.096 31.722 59.225 1.00 12.28 C

ATOM 350 ODl ASN A 64 12.970 31.785 59.718 1.00 11.13 O

ATOM 351 ND2 ASN A 64 14.399 30.889 58.228 1.00 12.14 N

ATOM 352 C ASN A 64 15.889 34.983 60.317 1.00 11.82 C

ATOM 353 O ASN A 64 16.426 34.599 61.359 1.00 11.76 O

ATOM 354 N GLU A 65 16.137 36.168 59.763 1.00 11.38 N

ATOM 355 CA GLU A 65 17.054 37.131 60.377 1.00 11.50 C

ATOM 356 CB GLU A 65 18.292 37.323 59.499 1.00 11.68 C

ATOM 357 CG GLU A 65 19.124 36.047 59.364 1.00 12.95 C

ATOM 358 CD GLU A 65 20.323 36.192 58.442 1.00 14.96 C

ATOM 359 OEl GLU A 65 21.344 35.521 58.713 1.00 17.25 O

ATOM 360 OE2 GLU A 65 20.248 36.960 57.455 1.00 15.97 O

ATOM 361 C GLU A 65 16.355 38.460 60.635 1.00 11.04 C

ATOM 362 O GLU A 65 15.488 38.869 59.863 1.00 11.25 O

ATOM 363 N ILE A 66 16.727 39.120 61.730 1.00 10.48 N

ATOM 364 CA ILE A 66 16.155 40.421 62.083 1.00 9.92 C

ATOM 365 CB ILE A 66 16.528 40.827 63.541 1.00 9.95 C

ATOM 366 CGl ILE A 66 15.759 42.080 63.979 1.00 9.28 C

ATOM 367 CDl ILE A 66 15.748 42.291 65.483 1.00 8.95 C

ATOM 368 CG2 ILE A 66 18.047 40.944 63.715 1.00 9.77 C

ATOM 369 C ILE A 66 16.580 41.496 61.076 1.00 10.01 C

ATOM 370 O ILE A 66 17.720 41.494 60.600 1.00 9.70 O W2025-7029WO / AM102903-PCT

ATOM 371 N THR A 67 15.653 42.394 60.746 1.00 9.97 N

ATOM 372 CA THR A 67 15.905 43.442 59.760 1.00 10.48 C

ATOM 373 CB THR A 67 15.374 43.070 58.341 1.00 10.93 C

ATOM 374 OGl THR A 67 13.941 43.081 58.348 1.00 12.91 O

ATOM 375 CG2 THR A 67 15.885 41.710 57.875 1.00 11.37 C

ATOM 376 C THR A 67 15.220 44.743 60.133 1.00 10.20 C

ATOM 377 O THR A 67 14.308 44.776 60.970 1.00 9.89 O

ATOM 378 N THR A 68 15.645 45.811 59.467 1.00 9.96 N

ATOM 379 CA THR A 68 14.961 47.095 59.518 1.00 9.74 C

ATOM 380 CB THR A 68 15.830 48.202 58.899 1.00 9.92 C

ATOM 381 OGl THR A 68 16.123 47.859 57.540 1.00 9.35 O

ATOM 382 CG2 THR A 68 17.135 48.381 59.679 1.00 9.69 C

ATOM 383 C THR A 68 13.653 47.007 58.725 1.00 9.82 C

ATOM 384 O THR A 68 13.443 46.056 57.955 1.00 10.10 O

ATOM 385 N ILE A 69 12.780 47.994 58.905 1.00 9.58 N

ATOM 386 CA ILE A 69 11.540 48.074 58.117 1.00 9.43 C

ATOM 387 CB ILE A 69 10.274 47.622 58.916 1.00 9.53 C

ATOM 388 CGl ILE A 69 9.979 48.573 60.089 1.00 9.58 C

ATOM 389 CDl ILE A 69 8.684 48.247 60.840 1.00 10.63 C

ATOM 390 CG2 ILE A 69 10.415 46.152 59.365 1.00 8.93 C

ATOM 391 C ILE A 69 11.308 49.438 57.443 1.00 9.83 C

ATOM 392 O ILE A 69 10.660 49.503 56.397 1.00 9.62 O

ATOM 393 N GLU A 70 11.828 50.512 58.040 1.00 9.22 N

ATOM 394 CA GLU A 70 11.774 51.838 57.410 1.00 9.79 C

ATOM 395 CB GLU A 70 11.389 52.937 58.408 1.00 9.49 C

ATOM 396 CG GLU A 70 9.964 52.844 58.976 1.00 10.49 C

ATOM 397 CD GLU A 70 8.869 53.323 58.011 1.00 11.39 C

ATOM 398 OEl GLU A 70 7.678 53.216 58.375 1.00 12.16 O

ATOM 399 OE2 GLU A 70 9.180 53.800 56.899 1.00 11.03 O

ATOM 400 C GLU A 70 13.116 52.165 56.773 1.00 9.73 C

ATOM 401 O GLU A 70 14.170 51.760 57.274 1.00 9.86 O

ATOM 402 N TRP A 71 13.067 52.913 55.674 1.00 10.12 N

ATOM 403 CA TRP A 71 14.251 53.209 54.876 1.00 10.47 C

ATOM 404 CB TRP A 71 13.870 54.098 53.690 1.00 10.89 C

ATOM 405 CG TRP A 71 13.711 55.535 54.053 1.00 11.75 C

ATOM 406 CDl TRP A 71 12.619 56.132 54.611 1.00 12.49 C

ATOM 407 NEl TRP A 71 12.864 57.472 54.811 1.00 12.89 N

ATOM 408 CE2 TRP A 71 14.134 57.759 54.380 1.00 13.13 C

ATOM 409 CD2 TRP A 71 14.698 56.561 53.898 1.00 12.31 C

ATOM 410 CE3 TRP A 71 16.006 56.580 53.394 1.00 12.95 C

ATOM 411 CZ3 TRP A 71 16.700 57.783 53.387 1.00 12.87 C

ATOM 412 CH2 TRP A 71 16.108 58.961 53.873 1.00 12.85 C

ATOM 413 CZ2 TRP A 71 14.831 58.970 54.371 1.00 13.01 C

ATOM 414 C TRP A 71 15.375 53.857 55.695 1.00 10.26 C

ATOM 415 O TRP A 71 16.553 53.625 55.422 1.00 10.58 O

ATOM 416 N ASN A 72 15.003 54.654 56.699 1.00 10.05 N

ATOM 417 CA ASN A 72 15.977 55.407 57.498 1.00 10.02 C

ATOM 418 CB ASN A 72 15.594 56.899 57.559 1.00 10.31 C

ATOM 419 CG ASN A 72 14.228 57.141 58.203 1.00 10.47 C

ATOM 420 ODl ASN A 72 13.391 56.235 58.300 1.00 10.99 O

ATOM 421 ND2 ASN A 72 13.996 58.378 58.636 1.00 10.55 N

ATOM 422 C ASN A 72 16.188 54.856 58.912 1.00 10.09 C

ATOM 423 O ASN A 72 16.686 55.568 59.787 1.00 9.78 O

ATOM 424 N ASP A 73 15.831 53.590 59.129 1.00 10.26 N

ATOM 425 CA ASP A 73 15.959 52.988 60.464 1.00 10.50 C

ATOM 426 CB ASP A 73 15.457 51.541 60.489 1.00 10.32 C

ATOM 427 CG ASP A 73 13.974 51.433 60.798 1.00 9.97 C

ATOM 428 ODl ASP A 73 13.404 52.342 61.449 1.00 8.92 O

ATOM 429 OD2 ASP A 73 13.374 50.409 60.408 1.00 9.67 O

ATOM 430 C ASP A 73 17.375 53.069 61.044 1.00 10.65 C

ATOM 431 O ASP A 73 17.536 53.340 62.237 1.00 10.54 O

ATOM 432 N VAL A 74 18.399 52.858 60.213 1.00 10.92 N

ATOM 433 CA VAL A 74 19.781 52.927 60.715 1.00 11.53 C W2025-7029WO / AM102903-PCT

ATOM 434 CB VAL A 74 20.822 52.471 59.664 1.00 11.39 C

ATOM 435 CGl VAL A 74 22.249 52.718 60.165 1.00 11.78 C

ATOM 436 CG2 VAL A 74 20.637 50.990 59.347 1.00 12.48 C

ATOM 437 C VAL A 74 20.110 54.319 61.275 1.00 11.52 C

ATOM 438 O VAL A 74 20.680 54.431 62.363 1.00 11.67 O

ATOM 439 N THR A 75 19.740 55.368 60.540 1.00 11.43 N

ATOM 440 CA THR A 75 19.906 56.738 61.020 1.00 11.78 C

ATOM 441 CB THR A 75 19.455 57.772 59.965 1.00 12.08 C

ATOM 442 OGl THR A 75 20.210 57.580 58.762 1.00 12.74 O

ATOM 443 CG2 THR A 75 19.661 59.199 60.472 1.00 12.94 C

ATOM 444 C THR A 75 19.133 56.948 62.322 1.00 11.57 C

ATOM 445 O THR A 75 19.659 57.529 63.279 1.00 11.67 O

ATOM 446 N LEU A 76 17.892 56.463 62.356 1.00 11.02 N

ATOM 447 CA LEU A 76 17.051 56.605 63.549 1.00 10.86 C

ATOM 448 CB LEU A 76 15.596 56.232 63.253 1.00 10.70 C

ATOM 449 CG LEU A 76 14.879 57.074 62.192 1.00 10.69 C

ATOM 450 CDl LEU A 76 13.485 56.523 61.932 1.00 11.32 C

ATOM 451 CD2 LEU A 76 14.823 58.554 62.559 1.00 10.39 C

ATOM 452 C LEU A 76 17.589 55.819 64.745 1.00 10.75 C

ATOM 453 O LEU A 76 17.531 56.309 65.872 1.00 10.85 O

ATOM 454 N TYR A 77 18.129 54.623 64.499 1.00 10.77 N

ATOM 455 CA TYR A 77 18.758 53.826 65.564 1.00 10.98 C

ATOM 456 CB TYR A 77 19.403 52.541 65.023 1.00 10.86 C

ATOM 457 CG TYR A 77 18.501 51.441 64.502 1.00 10.00 C

ATOM 458 CDl TYR A 77 17.133 51.396 64.792 1.00 9.53 C

ATOM 459 CEl TYR A 77 16.329 50.348 64.302 1.00 8.68 C

ATOM 460 CZ TYR A 77 16.915 49.341 63.537 1.00 9.48 C

ATOM 461 OH TYR A 77 16.168 48.302 63.043 1.00 9.23 O

ATOM 462 CE2 TYR A 77 18.269 49.364 63.258 1.00 8.90 C

ATOM 463 CD2 TYR A 77 19.050 50.403 63.742 1.00 10.01 C

ATOM 464 C TYR A 77 19.881 54.633 66.204 1.00 11.47 C

ATOM 465 O TYR A 77 20.050 54.638 67.421 1.00 11.46 O

ATOM 466 N GLN A 78 20.668 55.267 65.354 1.00 11.89 N

ATOM 467 CA GLN A 78 21.804 56.047 65.791 1.00 12.59 C

ATOM 468 CB GLN A 78 22.491 56.582 64.562 1.00 13.15 C

ATOM 469 CG GLN A 78 23.824 57.073 64.775 1.00 17.25 C

ATOM 470 CD GLN A 78 24.623 57.063 63.483 1.00 21.47 C

ATOM 471 OEl GLN A 78 24.085 56.790 62.387 1.00 23.96 O

ATOM 472 NE2 GLN A 78 25.925 57.334 63.606 1.00 23.43 N

ATOM 473 C GLN A 78 21.409 57.208 66.704 1.00 11.92 C

ATOM 474 O GLN A 78 22.052 57.444 67.717 1.00 11.92 O

ATOM 475 N ALA A 79 20.359 57.928 66.322 1.00 11.41 N

ATOM 476 CA ALA A 79 19.850 59.034 67.127 1.00 11.00 C

ATOM 477 CB ALA A 79 18.854 59.861 66.331 1.00 11.09 C

ATOM 478 C ALA A 79 19.216 58.507 68.417 1.00 10.83 C

ATOM 479 O ALA A 79 19.396 59.088 69.493 1.00 10.76 O

ATOM 480 N PHE A 80 18.497 57.392 68.287 1.00 10.33 N

ATOM 481 CA PHE A 80 17.769 56.757 69.387 1.00 10.09 C

ATOM 482 CB PHE A 80 16.936 55.596 68.829 1.00 9.97 C

ATOM 483 CG PHE A 80 15.999 54.964 69.823 1.00 9.58 C

ATOM 484 CDl PHE A 80 16.314 53.738 70.404 1.00 8.47 C

ATOM 485 CEl PHE A 80 15.439 53.126 71.307 1.00 8.85 C

ATOM 486 CZ PHE A 80 14.242 53.749 71.635 1.00 8.67 C

ATOM 487 CE2 PHE A 80 13.917 54.975 71.065 1.00 9.49 C

ATOM 488 CD2 PHE A 80 14.793 55.580 70.158 1.00 9.38 C

ATOM 489 C PHE A 80 18.734 56.269 70.464 1.00 10.15 C

ATOM 490 O PHE A 80 18.644 56.666 71.629 1.00 10.32 O

ATOM 491 N ASN A 81 19.673 55.420 70.069 1.00 10.27 N

ATOM 492 CA ASN A 81 20.658 54.913 71.007 1.00 10.61 C

ATOM 493 CB ASN A 81 21.345 53.674 70.438 1.00 10.58 C

ATOM 494 CG ASN A 81 20.384 52.506 70.298 1.00 11.01 C

ATOM 495 ODl ASN A 81 19.494 52.327 71.134 1.00 12.14 O

ATOM 496 ND2 ASN A 81 20.546 51.714 69.243 1.00 10.23 N W2025-7029WO / AM102903-PCT

ATOM 497 C ASN A 81 21.643 55.977 71.476 1.00 10.83 C

ATOM 498 O ASN A 81 22.188 55.881 72.574 1.00 10.84 O

ATOM 499 N GLY A 82 21.826 57.013 70.656 1.00 11.38 N

ATOM 500 CA GLY A 82 22.622 58.181 71.033 1.00 11.73 C

ATOM 501 C GLY A 82 22.077 58.967 72.220 1.00 12.00 C

ATOM 502 O GLY A 82 22.813 59.722 72.854 1.00 12.59 O

ATOM 503 N LEU A 83 20.790 58.797 72.524 1.00 11.86 N

ATOM 504 CA LEU A 83 20.190 59.383 73.729 1.00 11.88 C

ATOM 505 CB LEU A 83 18.690 59.071 73.819 1.00 11.93 C

ATOM 506 CG LEU A 83 17.800 59.701 72.737 1.00 11.76 C

ATOM 507 CDl LEU A 83 16.434 59.034 72.696 1.00 12.31 C

ATOM 508 CD2 LEU A 83 17.667 61.216 72.916 1.00 12.34 C

ATOM 509 C LEU A 83 20.899 58.915 75.000 1.00 12.04 C

ATOM 510 O LEU A 83 20.910 59.627 76.003 1.00 11.82 O

ATOM 511 N LYS A 84 21.494 57.724 74.945 1.00 12.18 N

ATOM 512 CA LYS A 84 22.260 57.186 76.071 1.00 12.79 C

ATOM 513 CB LYS A 84 22.615 55.712 75.837 1.00 12.47 C

ATOM 514 CG LYS A 84 21.405 54.779 75.882 1.00 12.29 C

ATOM 515 CD LYS A 84 21.805 53.307 75.787 1.00 11.11 C

ATOM 516 CE LYS A 84 22.076 52.871 74.347 1.00 11.43 C

ATOM 517 NZ LYS A 84 22.617 51.477 74.288 1.00 9.08 N

ATOM 518 C LYS A 84 23.506 58.016 76.388 1.00 13.55 C

ATOM 519 O LYS A 84 24.023 57.965 77.508 1.00 13.82 O

ATOM 520 N ASN A 85 23.967 58.794 75.409 1.00 14.44 N

ATOM 521 CA ASN A 85 25.060 59.751 75.620 1.00 15.50 C

ATOM 522 CB ASN A 85 25.608 60.247 74.281 1.00 15.58 C

ATOM 523 CG ASN A 85 26.385 59.176 73.538 1.00 16.35 C

ATOM 524 ODl ASN A 85 26.940 58.256 74.147 1.00 17.34 O

ATOM 525 ND2 ASN A 85 26.427 59.288 72.216 1.00 18.29 N

ATOM 526 C ASN A 85 24.666 60.942 76.493 1.00 16.14 C

ATOM 527 O ASN A 85 25.518 61.751 76.863 1.00 16.63 O

ATOM 528 N LYS A 86 23.378 61.040 76.813 1.00 16.55 N

ATOM 529 CA LYS A 86 22.851 62.129 77.637 1.00 16.89 C

ATOM 530 CB LYS A 86 21.755 62.884 76.876 1.00 17.15 C

ATOM 531 CG LYS A 86 22.233 63.553 75.585 1.00 18.45 C

ATOM 532 CD LYS A 86 21.131 64.372 74.935 1.00 20.04 C

ATOM 533 CE LYS A 86 21.695 65.287 73.852 1.00 21.69 C

ATOM 534 NZ LYS A 86 20.632 66.034 73.121 1.00 23.33 N

ATOM 535 C LYS A 86 22.314 61.618 78.979 1.00 16.78 C

ATOM 536 O LYS A 86 21.990 62.409 79.869 1.00 17.19 O

ATOM 537 N ASN A 87 22.206 60.298 79.109 1.00 16.39 N

ATOM 538 CA ASN A 87 21.749 59.659 80.342 1.00 16.15 C

ATOM 539 CB ASN A 87 20.222 59.493 80.343 1.00 16.07 C

ATOM 540 CG ASN A 87 19.698 58.752 81.577 1.00 15.79 C

ATOM 541 ODl ASN A 87 20.464 58.304 82.434 1.00 15.77 O

ATOM 542 ND2 ASN A 87 18.376 58.616 81.662 1.00 15.90 N

ATOM 543 C ASN A 87 22.451 58.316 80.499 1.00 16.46 C

ATOM 544 O ASN A 87 22.104 57.342 79.825 1.00 16.40 O

ATOM 545 N SER A 88 23.431 58.280 81.402 1.00 16.49 N

ATOM 546 CA SER A 88 24.312 57.123 81.594 1.00 16.62 C

ATOM 547 CB SER A 88 25.418 57.464 82.602 1.00 16.70 C

ATOM 548 OG SER A 88 24.871 57.827 83.862 1.00 17.66 O

ATOM 549 C SER A 88 23.592 55.858 82.055 1.00 16.48 C

ATOM 550 O SER A 88 24.130 54.757 81.934 1.00 17.02 O

ATOM 551 N GLN A 89 22.384 56.022 82.589 1.00 15.97 N

ATOM 552 CA GLN A 89 21.634 54.904 83.163 1.00 15.84 C

ATOM 553 CB GLN A 89 20.941 55.330 84.462 1.00 16.15 C

ATOM 554 CG GLN A 89 21.857 55.991 85.502 1.00 19.05 C

ATOM 555 CD GLN A 89 22.308 55.057 86.613 1.00 21.87 C

ATOM 556 OEl GLN A 89 22.624 55.509 87.717 1.00 23.98 O

ATOM 557 NE2 GLN A 89 22.345 53.753 86.335 1.00 22.73 N

ATOM 558 C GLN A 89 20.599 54.356 82.180 1.00 14.78 C

ATOM 559 O GLN A 89 20.071 53.260 82.371 1.00 14.57 O W2025-7029WO / AM102903-PCT

ATOM 560 N LEU A 90 20.314 55.130 81.137 1.00 13.83 N

ATOM 561 CA LEU A 90 19.301 54.760 80.145 1.00 12.92 C

ATOM 562 CB LEU A 90 19.095 55.904 79.149 1.00 12.86 C

ATOM 563 CG LEU A 90 17.961 55.807 78.119 1.00 12.31 C

ATOM 564 CDl LEU A 90 16.580 55.825 78.805 1.00 11.97 C

ATOM 565 CD2 LEU A 90 18.079 56.943 77.117 1.00 12.24 C

ATOM 566 C LEU A 90 19.675 53.475 79.407 1.00 12.55 C

ATOM 567 O LEU A 90 20.833 53.282 79.020 1.00 12.35 O

ATOM 568 N LYS A 91 18.686 52.600 79.226 1.00 11.80 N

ATOM 569 CA LYS A 91 18.865 51.379 78.441 1.00 11.45 C

ATOM 570 CB LYS A 91 18.703 50.125 79.308 1.00 12.11 C

ATOM 571 CG LYS A 91 19.673 50.018 80.484 1.00 14.28 C

ATOM 572 CD LYS A 91 21.127 49.959 80.038 1.00 17.61 C

ATOM 573 CE LYS A 91 22.056 49.935 81.244 1.00 19.87 C

ATOM 574 NZ LYS A 91 23.383 50.538 80.940 1.00 22.01 N

ATOM 575 C LYS A 91 17.852 51.362 77.308 1.00 10.78 C

ATOM 576 O LYS A 91 16.751 51.895 77.449 1.00 10.52 O

ATOM 577 N THR A 92 18.239 50.763 76.186 1.00 9.81 N

ATOM 578 CA THR A 92 17.393 50.725 74.995 1.00 9.13 C

ATOM 579 CB THR A 92 17.994 51.542 73.830 1.00 9.30 C

ATOM 580 OGl THR A 92 19.268 50.992 73.458 1.00 8.62 O

ATOM 581 CG2 THR A 92 18.142 53.029 74.202 1.00 8.57 C

ATOM 582 C THR A 92 17.182 49.296 74.517 1.00 8.85 C

ATOM 583 O THR A 92 18.072 48.452 74.637 1.00 8.68 O

ATOM 584 N LEU A 93 15.995 49.024 73.981 1.00 8.24 N

ATOM 585 CA LEU A 93 15.710 47.730 73.372 1.00 8.14 C

ATOM 586 CB LEU A 93 14.813 46.850 74.266 1.00 7.82 C

ATOM 587 CG LEU A 93 15.338 46.481 75.665 1.00 8.56 C

ATOM 588 CDl LEU A 93 14.982 47.564 76.670 1.00 9.15 C

ATOM 589 CD2 LEU A 93 14.776 45.133 76.121 1.00 8.88 C

ATOM 590 C LEU A 93 15.072 47.933 72.010 1.00 8.02 C

ATOM 591 O LEU A 93 14.522 49.004 71.712 1.00 7.93 O

ATOM 592 N LEU A 94 15.180 46.906 71.176 1.00 7.80 N

ATOM 593 CA LEU A 94 14.542 46.897 69.878 1.00 7.71 C

ATOM 594 CB LEU A 94 15.560 46.547 68.785 1.00 7.81 C

ATOM 595 CG LEU A 94 15.077 46.404 67.339 1.00 7.61 C

ATOM 596 CDl LEU A 94 14.474 47.702 66.817 1.00 8.81 C

ATOM 597 CD2 LEU A 94 16.229 45.953 66.447 1.00 7.46 C

ATOM 598 C LEU A 94 13.413 45.875 69.910 1.00 7.54 C

ATOM 599 O LEU A 94 13.638 44.706 70.234 1.00 7.50 O

ATOM 600 N ALA A 95 12.206 46.328 69.579 1.00 7.67 N

ATOM 601 CA ALA A 95 11.051 45.441 69.502 1.00 7.16 C

ATOM 602 CB ALA A 95 9.770 46.176 69.885 1.00 7.37 C

ATOM 603 C ALA A 95 10.929 44.857 68.105 1.00 7.21 C

ATOM 604 O ALA A 95 11.004 45.589 67.108 1.00 7.33 O

ATOM 605 N ILE A 96 10.750 43.540 68.036 1.00 6.71 N

ATOM 606 CA ILE A 96 10.506 42.870 66.756 1.00 6.75 C

ATOM 607 CB ILE A 96 11.503 41.692 66.487 1.00 6.41 C

ATOM 608 CGl ILE A 96 11.313 41.142 65.063 1.00 7.42 C

ATOM 609 CDl ILE A 96 12.298 40.036 64.673 1.00 6.65 C

ATOM 610 CG2 ILE A 96 11.410 40.589 67.587 1.00 6.23 C

ATOM 611 C ILE A 96 9.053 42.407 66.663 1.00 6.85 C

ATOM 612 O ILE A 96 8.531 41.793 67.599 1.00 7.33 O

ATOM 613 N GLY A 97 8.404 42.723 65.544 1.00 7.20 N

ATOM 614 CA GLY A 97 7.058 42.231 65.274 1.00 7.30 C

ATOM 615 C GLY A 97 5.994 43.307 65.289 1.00 7.63 C

ATOM 616 O GLY A 97 6.020 44.242 64.474 1.00 7.80 O

ATOM 617 N GLY A 98 5.054 43.171 66.223 1.00 7.70 N

ATOM 618 CA GLY A 98 3.900 44.064 66.300 1.00 7.88 C

ATOM 619 C GLY A 98 2.633 43.413 65.768 1.00 8.24 C

ATOM 620 O GLY A 98 2.683 42.367 65.107 1.00 7.72 O

ATOM 621 N TRP A 99 1.495 44.045 66.050 1.00 8.34 N

ATOM 622 CA TRP A 99 0.194 43.547 65.596 1.00 9.01 C W2025-7029WO / AM102903-PCT

ATOM 623 CB TRP A 99 0.906 44.530 66.015 1.00 9.41 C

ATOM 624 CG TRP A 99 2.276 44.140 65.544 1.00 10.72 C

ATOM 625 CDl TRP A 99 2.935 44.628 64.453 1.00 12.14 C

ATOM 626 NEl TRP A 99 4.168 44.034 64.339 1.00 12.47 N

ATOM 627 CE2 TRP A 99 4.329 43.141 65.365 1.00 12.14 C

ATOM 628 CD2 TRP A 99 3.152 43.179 66.146 1.00 11.95 C

ATOM 629 CE3 TRP A 99 3.063 42.353 67.276 1.00 11.62 C

ATOM 630 CZ3 TRP A 99 4.136 41.515 67.577 1.00 12.02 C

ATOM 631 CH2 TRP A 99 5.295 41.502 66.779 1.00 12.18 C

ATOM 632 CZ2 TRP A 99 5.410 42.306 65.672 1.00 12.55 C

ATOM 633 C TRP A 99 0.147 43.290 64.079 1.00 8.84 C

ATOM 634 O TRP A 99 0.228 42.199 63.629 1.00 8.85 O

ATOM 635 N ASN A 100 0.549 44.286 63.296 1.00 8.91 N

ATOM 636 CA ASN A 100 0.467 44.202 61.831 1.00 9.26 C

ATOM 637 CB ASN A 100 0.659 45.585 61.198 1.00 9.42 C

ATOM 638 CG ASN A 100 0.520 46.518 61.442 1.00 10.16 C

ATOM 639 ODl ASN A 100 1.601 46.087 61.865 1.00 10.90 O

ATOM 640 ND2 ASN A 100 0.320 47.806 61.161 1.00 9.53 N

ATOM 641 C ASN A 100 1.457 43.209 61.214 1.00 9.28 C

ATOM 642 O ASN A 100 1.316 42.824 60.053 1.00 9.85 O

ATOM 643 N PHE A 101 2.460 42.807 61.989 1.00 8.79 N

ATOM 644 CA PHE A 101 3.466 41.863 61.516 1.00 8.60 C

ATOM 645 CB PHE A 101 4.640 41.840 62.492 1.00 8.95 C

ATOM 646 CG PHE A 101 5.831 41.039 62.026 1.00 8.72 C

ATOM 647 CDl PHE A 101 6.740 41.575 61.116 1.00 9.48 C

ATOM 648 CEl PHE A 101 7.854 40.842 60.706 1.00 9.22 C

ATOM 649 CZ PHE A 101 8.072 39.562 61.214 1.00 9.65 C

ATOM 650 CE2 PHE A 101 7.179 39.019 62.130 1.00 9.69 C

ATOM 651 CD2 PHE A 101 6.069 39.764 62.537 1.00 9.57 C

ATOM 652 C PHE A 101 2.859 40.468 61.366 1.00 8.70 C

ATOM 653 O PHE A 101 3.296 39.677 60.536 1.00 8.50 O

ATOM 654 N GLY A 102 1.836 40.181 62.167 1.00 8.80 N

ATOM 655 CA GLY A 102 1.235 38.852 62.186 1.00 8.81 C

ATOM 656 C GLY A 102 2.186 37.809 62.756 1.00 9.02 C

ATOM 657 O GLY A 102 3.141 38.137 63.472 1.00 8.94 O

ATOM 658 N THR A 103 1.942 36.546 62.415 1.00 9.12 N

ATOM 659 CA THR A 103 2.660 35.442 63.044 1.00 9.57 C

ATOM 660 CB THR A 103 1.688 34.480 63.763 1.00 9.94 C

ATOM 661 OGl THR A 103 0.781 33.913 62.808 1.00 9.95 O

ATOM 662 CG2 THR A 103 0.898 35.218 64.845 1.00 9.78 C

ATOM 663 C THR A 103 3.518 34.616 62.085 1.00 9.84 C

ATOM 664 O THR A 103 4.430 33.913 62.528 1.00 9.67 O

ATOM 665 N ALA A 104 3.221 34.691 60.786 1.00 9.94 N

ATOM 666 CA ALA A 104 3.849 33.789 59.804 1.00 10.31 C

ATOM 667 CB ALA A 104 3.391 34.115 58.388 1.00 10.71 C

ATOM 668 C ALA A 104 5.390 33.689 59.892 1.00 10.37 C

ATOM 669 O ALA A 104 5.925 32.574 59.936 1.00 10.55 O

ATOM 670 N PRO A 105 6.108 34.839 59.904 1.00 10.40 N

ATOM 671 CA PRO A 105 7.566 34.750 60.037 1.00 9.99 C

ATOM 672 CB PRO A 105 8.026 36.205 59.862 1.00 10.57 C

ATOM 673 CG PRO A 105 6.900 36.880 59.144 1.00 10.46 C

ATOM 674 CD PRO A 105 5.681 36.242 59.740 1.00 10.18 C

ATOM 675 C PRO A 105 8.049 34.173 61.382 1.00 9.89 C

ATOM 676 O PRO A 105 9.071 33.474 61.416 1.00 9.74 O

ATOM 677 N PHE A 106 7.325 34.442 62.469 1.00 9.42 N

ATOM 678 CA PHE A 106 7.680 33.850 63.764 1.00 9.26 C

ATOM 679 CB PHE A 106 6.860 34.453 64.903 1.00 9.17 C

ATOM 680 CG PHE A 106 7.301 35.833 65.314 1.00 8.98 C

ATOM 681 CDl PHE A 106 8.535 36.030 65.936 1.00 9.78 C

ATOM 682 CEl PHE A 106 8.942 37.303 66.328 1.00 9.28 C

ATOM 683 CZ PHE A 106 8.105 38.399 66.111 1.00 9.94 C

ATOM 684 CE2 PHE A 106 6.861 38.209 65.502 1.00 9.82 C

ATOM 685 CD2 PHE A 106 6.468 36.930 65.108 1.00 10.01 C W2025-7029WO / AM102903-PCT

ATOM 686 C PHE A 106 7.513 32.336 63.748 1.00 9.24 C

ATOM 687 O PHE A 106 8.398 31.599 64.190 1.00 9.21 O

ATOM 688 N THR A 107 6.379 31.874 63.226 1.00 9.31 N

ATOM 689 CA THR A 107 6.105 30.445 63.139 1.00 9.71 C

ATOM 690 CB THR A 107 4.710 30.182 62.529 1.00 9.49 C

ATOM 691 OGl THR A 107 3.707 30.682 63.423 1.00 10.89 O

ATOM 692 CG2 THR A 107 4.473 28.688 62.307 1.00 10.24 C

ATOM 693 C THR A 107 7.208 29.722 62.355 1.00 9.41 C

ATOM 694 O THR A 107 7.746 28.709 62.814 1.00 9.85 O

ATOM 695 N ALA A 108 7.566 30.262 61.193 1.00 9.47 N

ATOM 696 CA ALA A 108 8.596 29.652 60.353 1.00 9.67 C

ATOM 697 CB ALA A 108 8.693 30.387 59.028 1.00 9.81 C

ATOM 698 C ALA A 108 9.953 29.641 61.055 1.00 9.90 C

ATOM 699 O ALA A 108 10.703 28.667 60.959 1.00 10.13 O

ATOM 700 N MET A 109 10.251 30.721 61.775 1.00 9.86 N

ATOM 701 CA MET A 109 11.536 30.871 62.458 1.00 10.37 C

ATOM 702 CB MET A 109 11.729 32.322 62.906 1.00 10.57 C

ATOM 703 CG MET A 109 13.073 32.617 63.533 1.00 10.25 C

ATOM 704 SD MET A 109 13.044 32.396 65.321 1.00 9.82 S

ATOM 705 CE MET A 109 11.969 33.756 65.793 1.00 10.20 C

ATOM 706 C MET A 109 11.717 29.888 63.622 1.00 10.40 C

ATOM 707 O MET A 109 12.800 29.326 63.800 1.00 10.86 O

ATOM 708 N VAL A 110 10.663 29.658 64.401 1.00 10.38 N

ATOM 709 CA VAL A 110 10.764 28.732 65.544 1.00 11.03 C

ATOM 710 CB VAL A 110 9.781 29.085 66.701 1.00 10.86 C

ATOM 711 CGl VAL A 110 10.043 30.502 67.218 1.00 11.28 C

ATOM 712 CG2 VAL A 110 8.321 28.898 66.269 1.00 10.94 C

ATOM 713 C VAL A 110 10.599 27.259 65.142 1.00 10.86 C

ATOM 714 O VAL A 110 10.899 26.355 65.933 1.00 11.35 O

ATOM 715 N SER A 111 10.139 27.029 63.911 1.00 10.63 N

ATOM 716 CA SER A 111 9.748 25.689 63.465 1.00 10.65 C

ATOM 717 CB SER A 111 9.064 25.743 62.093 1.00 10.52 C

ATOM 718 OG SER A 111 9.982 26.067 61.067 1.00 11.22 O

ATOM 719 C SER A 111 10.904 24.684 63.449 1.00 10.60 C

ATOM 720 O SER A 111 10.671 23.478 63.559 1.00 10.38 O

ATOM 721 N THR A 112 12.133 25.180 63.290 1.00 10.51 N

ATOM 722 CA THR A 112 13.332 24.330 63.321 1.00 11.05 C

ATOM 723 CB THR A 112 13.904 24.048 61.904 1.00 11.16 C

ATOM 724 OGl THR A 112 14.557 25.217 61.394 1.00 11.70 O

ATOM 725 CG2 THR A 112 12.804 23.596 60.931 1.00 11.74 C

ATOM 726 C THR A 112 14.431 24.948 64.184 1.00 11.13 C

ATOM 727 O THR A 112 14.562 26.180 64.233 1.00 10.75 O

ATOM 728 N PRO A 113 15.247 24.097 64.844 1.00 11.49 N

ATOM 729 CA PRO A 113 16.342 24.611 65.666 1.00 11.66 C

ATOM 730 CB PRO A 113 17.004 23.342 66.217 1.00 11.72 C

ATOM 731 CG PRO A 113 16.020 22.245 66.009 1.00 12.07 C

ATOM 732 CD PRO A 113 15.198 22.621 64.837 1.00 11.33 C

ATOM 733 C PRO A 113 17.344 25.407 64.832 1.00 11.70 C

ATOM 734 O PRO A 113 17.922 26.384 65.319 1.00 12.18 O

ATOM 735 N GLU A 114 17.536 24.995 63.580 1.00 11.84 N

ATOM 736 CA GLU A 114 18.450 25.679 62.671 1.00 11.72 C

ATOM 737 CB GLU A 114 18.634 24.866 61.389 1.00 12.39 C

ATOM 738 CG GLU A 114 19.267 23.487 61.616 1.00 14.09 C

ATOM 739 CD GLU A 114 18.273 22.394 62.009 1.00 17.04 C

ATOM 740 OEl GLU A 114 17.044 22.620 61.943 1.00 16.83 O

ATOM 741 OE2 GLU A 114 18.729 21.286 62.382 1.00 18.91 O

ATOM 742 C GLU A 114 17.978 27.107 62.367 1.00 11.20 C

ATOM 743 O GLU A 114 18.785 28.040 62.338 1.00 11.43 O

ATOM 744 N ASN A 115 16.671 27.271 62.152 1.00 10.72 N

ATOM 745 CA ASN A 115 16.080 28.597 61.949 1.00 10.24 C

ATOM 746 CB ASN A 115 14.615 28.483 61.507 1.00 10.30 C

ATOM 747 CG ASN A 115 14.458 28.028 60.059 1.00 10.73 C

ATOM 748 ODl ASN A 115 15.438 27.767 59.354 1.00 11.17 O W2025-7029WO / AM102903-PCT

ATOM 749 ND2 ASN A 115 13.210 27.918 59.614 1.00 11.18 N

ATOM 750 C ASN A 115 16.193 29.491 63.194 1.00 10.02 C

ATOM 751 O ASN A 115 16.481 30.684 63.076 1.00 9.48 O

ATOM 752 N ARG A 116 15.993 28.908 64.379 1.00 9.63 N

ATOM 753 CA ARG A 116 16.154 29.654 65.635 1.00 9.63 C

ATOM 754 CB ARG A 116 15.701 28.833 66.846 1.00 9.41 C

ATOM 755 CG ARG A 116 14.239 28.451 66.819 1.00 9.11 C

ATOM 756 CD ARG A 116 13.753 28.020 68.192 1.00 9.26 C

ATOM 757 NE ARG A 116 14.446 26.832 68.698 1.00 8.93 N

ATOM 758 CZ ARG A 116 14.078 25.577 68.459 1.00 10.12 C

ATOM 759 NHl ARG A 116 13.029 25.310 67.686 1.00 10.46 N

ATOM 760 NH2 ARG A 116 14.776 24.576 68.991 1.00 10.10 N

ATOM 761 C ARG A 116 17.594 30.117 65.829 1.00 9.96 C

ATOM 762 O ARG A 116 17.829 31.255 66.227 1.00 9.95 O

ATOM 763 N GLN A 117 18.552 29.235 65.539 1.00 10.00 N

ATOM 764 CA GLN A 117 19.964 29.596 65.607 1.00 10.29 C

ATOM 765 CB GLN A 117 20.863 28.374 65.356 1.00 10.93 C

ATOM 766 CG GLN A 117 22.357 28.643 65.501 1.00 14.12 C

ATOM 767 CD GLN A 117 22.742 29.084 66.903 1.00 18.41 C

ATOM 768 OEl GLN A 117 22.690 30.273 67.233 1.00 20.97 O

ATOM 769 NE2 GLN A 117 23.142 28.126 67.734 1.00 20.77 N

ATOM 770 C GLN A 117 20.309 30.734 64.643 1.00 9.75 C

ATOM 771 O GLN A 117 20.985 31.689 65.030 1.00 9.29 O

ATOM 772 N THR A 118 19.848 30.626 63.398 1.00 9.29 N

ATOM 773 CA THR A 118 20.044 31.683 62.399 1.00 9.63 C

ATOM 774 CB THR A 118 19.382 31.301 61.055 1.00 9.79 C

ATOM 775 OGl THR A 118 20.028 30.137 60.523 1.00 10.64 O

ATOM 776 CG2 THR A 118 19.488 32.425 60.032 1.00 9.81 C

ATOM 111 C THR A 118 19.512 33.020 62.941 1.00 9.45 C

ATOM US, O THR A 118 20.194 34.054 62.883 1.00 9.29 O

ATOM 119 N PHE A 119 18.315 32.978 63.516 1.00 9.01 N

ATOM 780 CA PHE A 119 17.712 34.175 64.090 1.00 9.15 C

ATOM 781 CB PHE A 119 16.275 33.898 64.511 1.00 9.11 C

ATOM 782 CG PHE A 119 15.568 35.104 65.056 1.00 8.99 C

ATOM 783 CDl PHE A 119 15.212 36.155 64.212 1.00 8.09 C

ATOM 784 CEl PHE A 119 14.566 37.281 64.705 1.00 9.10 C

ATOM 785 CZ PHE A 119 14.255 37.365 66.066 1.00 9.46 C

ATOM 786 CE2 PHE A 119 14.612 36.320 66.922 1.00 9.11 C

ATOM 787 CD2 PHE A 119 15.269 35.197 66.410 1.00 8.78 C

ATOM 788 C PHE A 119 18.497 34.758 65.267 1.00 9.02 C

ATOM 789 O PHE A 119 18.791 35.956 65.287 1.00 9.01 O

ATOM 790 N ILE A 120 18.825 33.912 66.239 1.00 9.37 N

ATOM 791 CA ILE A 120 19.546 34.352 67.439 1.00 9.52 C

ATOM 792 CB ILE A 120 19.698 33.198 68.455 1.00 9.73 C

ATOM 793 CGl ILE A 120 18.326 32.815 69.026 1.00 9.12 C

ATOM 794 CDl ILE A 120 18.281 31.445 69.710 1.00 10.61 C

ATOM 795 CG2 ILE A 120 20.660 33.580 69.583 1.00 9.91 C

ATOM 796 C ILE A 120 20.895 34.978 67.070 1.00 9.68 C

ATOM 797 O ILE A 120 21.220 36.075 67.528 1.00 9.61 O

ATOM 798 N THR A 121 21.658 34.294 66.217 1.00 9.97 N

ATOM 799 CA THR A 121 22.920 34.831 65.708 1.00 10.19 C

ATOM 800 CB THR A 121 23.594 33.849 64.711 1.00 10.27 C

ATOM 801 OGl THR A 121 23.872 32.619 65.388 1.00 10.98 O

ATOM 802 CG2 THR A 121 24.906 34.423 64.181 1.00 10.59 C

ATOM 803 C THR A 121 22.740 36.221 65.085 1.00 10.16 C

ATOM 804 O THR A 121 23.509 37.144 65.381 1.00 9.83 O

ATOM 805 N SER A 122 21.716 36.372 64.244 1.00 10.03 N

ATOM 806 CA SER A 122 21.455 37.659 63.592 1.00 9.97 C

ATOM 807 CB SER A 122 20.366 37.533 62.518 1.00 10.50 C

ATOM 808 OG SER A 122 19.069 37.456 63.080 1.00 11.07 O

ATOM 809 C SER A 122 21.099 38.747 64.610 1.00 9.53 C

ATOM 810 O SER A 122 21.519 39.893 64.459 1.00 8.93 O

ATOM 811 N VAL A 123 20.341 38.378 65.645 1.00 8.73 N W2025-7029WO / AM102903-PCT

ATOM 812 CA VAL A 123 19.934 39.336 66.684 1.00 8.64 C

ATOM 813 CB VAL A 123 18.848 38.756 67.627 1.00 8.59 C

ATOM 814 CGl VAL A 123 18.643 39.651 68.852 1.00 8.70 C

ATOM 815 CG2 VAL A 123 17.543 38.566 66.869 1.00 7.64 C

ATOM 816 C VAL A 123 21.127 39.852 67.486 1.00 8.53 C

ATOM 817 O VAL A 123 21.256 41.058 67.696 1.00 8.51 O

ATOM 818 N ILE A 124 22.004 38.948 67.919 1.00 8.67 N

ATOM 819 CA ILE A 124 23.210 39.360 68.639 1.00 9.02 C

ATOM 820 CB ILE A 124 24.089 38.146 69.067 1.00 8.60 C

ATOM 821 CGl ILE A 124 23.331 37.280 70.089 1.00 9.16 C

ATOM 822 CDl ILE A 124 23.993 35.967 70.438 1.00 9.13 C

ATOM 823 CG2 ILE A 124 25.434 38.634 69.630 1.00 9.06 C

ATOM 824 C ILE A 124 24.015 40.353 67.793 1.00 9.35 C

ATOM 825 O ILE A 124 24.411 41.417 68.278 1.00 9.61 O

ATOM 826 N LYS A 125 24.227 40.015 66.522 1.00 9.84 N

ATOM 827 CA LYS A 125 24.976 40.876 65.612 1.00 10.14 C

ATOM 828 CB LYS A 125 25.152 40.183 64.253 1.00 10.34 C

ATOM 829 CG LYS A 125 26.084 40.913 63.303 1.00 12.05 C

ATOM 830 CD LYS A 125 26.288 40.128 62.010 1.00 14.57 C

ATOM 831 CE LYS A 125 27.195 40.898 61.052 1.00 17.05 C

ATOM 832 NZ LYS A 125 27.158 40.329 59.675 1.00 19.74 N

ATOM 833 C LYS A 125 24.320 42.253 65.444 1.00 9.90 C

ATOM 834 O LYS A 125 24.991 43.285 65.536 1.00 9.90 O

ATOM 835 N PHE A 126 23.008 42.246 65.225 1.00 9.63 N

ATOM 836 CA PHE A 126 22.210 43.448 64.958 1.00 9.66 C

ATOM 837 CB PHE A 126 20.773 43.020 64.642 1.00 9.52 C

ATOM 838 CG PHE A 126 19.988 44.007 63.819 1.00 9.79 C

ATOM 839 CDl PHE A 126 19.180 44.958 64.431 1.00 9.68 C

ATOM 840 CEl PHE A 126 18.432 45.853 63.665 1.00 10.07 C

ATOM 841 CZ PHE A 126 18.483 45.793 62.281 1.00 10.61 C

ATOM 842 CE2 PHE A 126 19.286 44.840 61.657 1.00 11.06 C

ATOM 843 CD2 PHE A 126 20.023 43.952 62.425 1.00 9.88 C

ATOM 844 C PHE A 126 22.222 44.414 66.150 1.00 9.62 C

ATOM 845 O PHE A 126 22.515 45.607 65.997 1.00 10.06 O

ATOM 846 N LEU A 127 21.918 43.888 67.337 1.00 9.43 N

ATOM 847 CA LEU A 127 21.869 44.692 68.561 1.00 9.31 C

ATOM 848 CB LEU A 127 21.348 43.864 69.742 1.00 8.83 C

ATOM 849 CG LEU A 127 19.936 43.281 69.629 1.00 8.84 C

ATOM 850 CDl LEU A 127 19.571 42.595 70.938 1.00 9.22 C

ATOM 851 CD2 LEU A 127 18.896 44.346 69.265 1.00 9.26 C

ATOM 852 C LEU A 127 23.221 45.293 68.905 1.00 9.26 C

ATOM 853 O LEU A 127 23.301 46.458 69.274 1.00 9.47 O

ATOM 854 N ARG A 128 24.272 44.499 68.787 1.00 9.78 N

ATOM 855 CA ARG A 128 25.611 44.991 69.045 1.00 10.16 C

ATOM 856 CB ARG A 128 26.619 43.849 69.072 1.00 10.30 C

ATOM 857 CG ARG A 128 26.519 42.912 70.289 1.00 10.09 C

ATOM 858 CD ARG A 128 26.438 43.639 71.626 1.00 10.38 C

ATOM 859 NE ARG A 128 26.572 42.765 72.779 1.00 10.87 N

ATOM 860 CZ ARG A 128 26.481 43.186 74.028 1.00 12.29 C

ATOM 861 NHl ARG A 128 26.237 44.464 74.262 1.00 12.00 N

ATOM 862 NH2 ARG A 128 26.617 42.336 75.031 1.00 11.75 N

ATOM 863 C ARG A 128 26.026 46.033 68.016 1.00 10.89 C

ATOM 864 O ARG A 128 26.605 47.024 68.360 1.00 10.89 O

ATOM 865 N GLN A 129 25.710 45.773 66.750 1.00 16.00 N

ATOM 866 CA GLN A 129 26.061 46.693 65.661 1.00 16.33 C

ATOM 867 CB GLN A 129 25.653 46.114 64.300 1.00 16.63 C

ATOM 868 CG GLN A 129 26.053 46.968 63.119 1.00 18.01 C

ATOM 869 CD GLN A 129 25.909 46.278 61.774 1.00 19.58 C

ATOM 870 OEl GLN A 129 25.437 45.161 61.681 1.00 20.90 O

ATOM 871 NE2 GLN A 129 26.263 46.988 60.712 1.00 20.65 N

ATOM 872 C GLN A 129 25.433 48.065 65.847 1.00 16.21 C

ATOM 873 O GLN A 129 26.071 49.073 65.654 1.00 11.96 O

ATOM 874 N TYR A 130 24.165 48.073 66.222 1.00 11.51 N W2025-7029WO / AM102903-PCT

ATOM 875 CA TYR A 130 23.416 49.318 66.285 1.00 11.66 C

ATOM 876 CB TYR A 130 22.080 49.182 65.560 1.00 11.71 C

ATOM 877 CG TYR A 130 22.243 48.853 64.087 1.00 12.26 C

ATOM 878 CDl TYR A 130 22.920 49.704 63.247 1.00 12.40 C

ATOM 879 CEl TYR A 130 23.080 49.411 61.931 1.00 12.30 C

ATOM 880 CZ TYR A 130 22.542 48.267 61.418 1.00 13.15 C

ATOM 881 OH TYR A 130 22.714 48.001 60.087 1.00 14.76 O

ATOM 882 CE2 TYR A 130 21.858 47.409 62.230 1.00 12.98 C

ATOM 883 CD2 TYR A 130 21.720 47.694 63.540 1.00 11.75 C

ATOM 884 C TYR A 130 23.290 49.900 67.698 1.00 11.54 C

ATOM 885 O TYR A 130 22.711 50.913 67.871 1.00 11.72 O

ATOM 886 N GLU A 131 23.869 49.218 68.668 1.00 11.61 N

ATOM 887 CA GLU A 131 24.034 49.710 70.043 1.00 11.98 C

ATOM 888 CB GLU A 131 24.774 51.065 70.069 1.00 12.41 C

ATOM 889 CG GLU A 131 26.235 50.923 69.626 1.00 14.86 C

ATOM 890 CD GLU A 131 26.954 52.239 69.381 1.00 18.09 C

ATOM 891 OEl GLU A 131 28.188 52.186 69.175 1.00 21.53 O

ATOM 892 OE2 GLU A 131 26.314 53.317 69.378 1.00 20.93 O

ATOM 893 C GLU A 131 22.742 49.717 70.862 1.00 11.29 C

ATOM 894 O GLU A 131 22.469 50.650 71.616 1.00 11.30 O

ATOM 895 N PHE A 132 21.965 48.646 70.696 1.00 10.17 N

ATOM 896 CA PHE A 132 20.801 48.361 71.535 1.00 9.36 C

ATOM 897 CB PHE A 132 19.740 47.615 70.730 1.00 9.15 C

ATOM 898 CG PHE A 132 18.964 48.483 69.795 1.00 8.48 C

ATOM 899 CDl PHE A 132 17.960 49.318 70.280 1.00 8.43 C

ATOM 900 CEl PHE A 132 17.221 50.126 69.418 1.00 10.14 C

ATOM 901 CZ PHE A 132 17.479 50.096 68.046 1.00 8.93 C

ATOM 902 CE2 PHE A 132 18.487 49.260 67.544 1.00 9.04 C

ATOM 903 CD2 PHE A 132 19.221 48.453 68.424 1.00 8.79 C

ATOM 904 C PHE A 132 21.215 47.482 72.707 1.00 8.92 C

ATOM 905 O PHE A 132 22.124 46.657 72.581 1.00 8.99 O

ATOM 906 N ASP A 133 20.524 47.630 73.838 1.00 8.48 N

ATOM 907 CA ASP A 133 20.835 46.841 75.033 1.00 8.24 C

ATOM 908 CB ASP A 133 20.693 47.702 76.290 1.00 8.79 C

ATOM 909 CG ASP A 133 21.591 48.917 76.257 1.00 9.02 C

ATOM 910 ODl ASP A 133 22.830 48.741 76.300 1.00 11.18 O

ATOM 911 OD2 ASP A 133 21.054 50.039 76.170 1.00 8.89 O

ATOM 912 C ASP A 133 20.000 45.567 75.172 1.00 8.06 C

ATOM 913 O ASP A 133 20.171 44.810 76.130 1.00 8.06 O

ATOM 914 N GLY A 134 19.108 45.325 74.217 1.00 7.48 N

ATOM 915 CA GLY A 134 18.318 44.097 74.239 1.00 7.67 C

ATOM 916 C GLY A 134 17.254 43.999 73.169 1.00 7.60 C

ATOM 917 O GLY A 134 17.083 44.917 72.360 1.00 7.16 O

ATOM 918 N LEU A 135 16.542 42.873 73.186 1.00 7.25 N

ATOM 919 CA LEU A 135 15.446 42.604 72.261 1.00 7.55 C

ATOM 920 CB LEU A 135 15.729 41.331 71.452 1.00 7.81 C

ATOM 921 CG LEU A 135 14.704 40.996 70.351 1.00 8.57 C

ATOM 922 CDl LEU A 135 14.960 41.821 69.088 1.00 9.65 C

ATOM 923 CD2 LEU A 135 14.688 39.515 70.014 1.00 8.48 C

ATOM 924 C LEU A 135 14.125 42.432 73.013 1.00 7.74 C

ATOM 925 O LEU A 135 14.068 41.712 74.013 1.00 8.18 O

ATOM 926 N ASP A 136 13.078 43.090 72.510 1.00 7.43 N

ATOM 927 CA ASP A 136 11.714 42.942 73.010 1.00 7.35 C

ATOM 928 CB ASP A 136 11.098 44.334 73.224 1.00 6.88 C

ATOM 929 CG ASP A 136 9.724 44.296 73.897 1.00 7.42 C

ATOM 930 ODl ASP A 136 9.537 43.539 74.876 1.00 7.16 O

ATOM 931 OD2 ASP A 136 8.838 45.051 73.441 1.00 7.38 O

ATOM 932 C ASP A 136 10.933 42.142 71.962 1.00 7.57 C

ATOM 933 O ASP A 136 10.715 42.621 70.844 1.00 7.96 O

ATOM 934 N PHE A 137 10.546 40.913 72.300 1.00 7.62 N

ATOM 935 CA PHE A 137 9.685 40.126 71.411 1.00 7.92 C

ATOM 936 CB PHE A 137 9.632 38.661 71.850 1.00 8.16 C

ATOM 937 CG PHE A 137 10.825 37.851 71.436 1.00 8.10 C W2025-7029WO / AM102903-PCT

ATOM 938 CDl PHE A 137 11.752 37.425 72.385 1.00 7.75 C

ATOM 939 CEl PHE A 137 12.855 36.648 72.005 1.00 8.52 C

ATOM 940 CZ PHE A 137 13.027 36.300 70.678 1.00 8.83 C

ATOM 941 CE2 PHE A 137 12.100 36.712 69.721 1.00 9.68 C

ATOM 942 CD2 PHE A 137 11.005 37.485 70.104 1.00 8.88 C

ATOM 943 C PHE A 137 8.268 40.680 71.412 1.00 7.99 C

ATOM 944 O PHE A 137 7.647 40.798 72.465 1.00 8.02 O

ATOM 945 N ASP A 138 7.751 40.998 70.233 1.00 7.68 N

ATOM 946 CA ASP A 138 6.353 41.386 70.117 1.00 7.96 C

ATOM 947 CB ASP A 138 6.206 42.873 69.786 1.00 7.90 C

ATOM 948 CG ASP A 138 4.773 43.343 69.882 1.00 8.73 C

ATOM 949 ODl ASP A 138 3.942 42.592 70.450 1.00 8.15 O

ATOM 950 OD2 ASP A 138 4.481 44.452 69.393 1.00 8.39 O

ATOM 951 C ASP A 138 5.640 40.506 69.092 1.00 7.85 C

ATOM 952 O ASP A 138 5.136 40.978 68.069 1.00 7.84 O

ATOM 953 N TRP A 139 5.626 39.212 69.379 1.00 8.22 N

ATOM 954 CA TRP A 139 4.924 38.233 68.562 1.00 8.25 C

ATOM 955 CB TRP A 139 5.564 36.866 68.796 1.00 8.22 C

ATOM 956 CG TRP A 139 4.957 35.690 68.090 1.00 8.60 C

ATOM 957 CDl TRP A 139 3.758 35.624 67.424 1.00 8.52 C

ATOM 958 NEl TRP A 139 3.564 34.348 66.929 1.00 9.39 N

ATOM 959 CE2 TRP A 139 4.630 33.566 67.294 1.00 8.70 C

ATOM 960 CD2 TRP A 139 5.523 34.380 68.031 1.00 8.72 C

ATOM 961 CE3 TRP A 139 6.709 33.817 68.518 1.00 8.33 C

ATOM 962 CZ3 TRP A 139 6.964 32.470 68.265 1.00 9.12 C

ATOM 963 CH2 TRP A 139 6.056 31.685 67.536 1.00 8.87 C

ATOM 964 CZ2 TRP A 139 4.888 32.214 67.038 1.00 9.07 C

ATOM 965 C TRP A 139 3.468 38.214 69.005 1.00 8.16 C

ATOM 966 O TRP A 139 3.165 37.848 70.138 1.00 8.18 O

ATOM 967 N GLU A 140 2.568 38.606 68.108 1.00 8.33 N

ATOM 968 CA GLU A 140 1.159 38.697 68.458 1.00 8.64 C

ATOM 969 CB GLU A 140 0.665 40.150 68.321 1.00 8.84 C

ATOM 970 CG GLU A 140 1.486 41.130 69.176 1.00 8.48 C

ATOM 971 CD GLU A 140 0.897 42.532 69.284 1.00 9.13 C

ATOM 972 OEl GLU A 140 -0.213 42.785 68.778 1.00 9.90 O

ATOM 973 OE2 GLU A 140 1.566 43.398 69.891 1.00 9.31 O

ATOM 974 C GLU A 140 0.329 37.724 67.606 1.00 8.94 C

ATOM 975 O GLU A 140 -0.092 38.078 66.505 1.00 9.15 O

ATOM 976 N TYR A 141 0.111 36.493 68.077 1.00 9.01 N

ATOM 977 CA TYR A 141 0.657 35.929 69.321 1.00 9.21 C

ATOM 978 CB TYR A 141 -0.385 35.969 70.443 1.00 9.19 C

ATOM 979 CG TYR A 141 -1.040 37.306 70.676 1.00 9.57 C

ATOM 980 CDl TYR A 141 -2.254 37.616 70.064 1.00 9.46 C

ATOM 981 CEl TYR A 141 -2.874 38.851 70.275 1.00 10.68 C

ATOM 982 CZ TYR A 141 -2.280 39.778 71.111 1.00 11.27 C

ATOM 983 OH TYR A 141 -2.899 40.994 71.313 1.00 12.49 O

ATOM 984 CE2 TYR A 141 -1.071 39.495 71.735 1.00 10.81 C

ATOM 985 CD2 TYR A 141 -0.458 38.260 71.516 1.00 9.54 C

ATOM 986 C TYR A 141 0.974 34.452 69.045 1.00 9.21 C

ATOM 987 O TYR A 141 0.391 33.875 68.126 1.00 9.22 O

ATOM 988 N PRO A 142 1.857 33.820 69.858 1.00 9.39 N

ATOM 989 CA PRO A 142 2.009 32.364 69.705 1.00 9.61 C

ATOM 990 CB PRO A 142 2.972 31.983 70.839 1.00 9.47 C

ATOM 991 CG PRO A 142 3.696 33.246 71.178 1.00 9.37 C

ATOM 992 CD PRO A 142 2.714 34.359 70.933 1.00 9.27 C

ATOM 993 C PRO A 142 0.660 31.667 69.920 1.00 9.80 C

ATOM 994 O PRO A 142 -0.095 32.069 70.803 1.00 9.67 O

ATOM 995 N GLY A 143 0.351 30.664 69.105 1.00 10.22 N

ATOM 996 CA GLY A 143 -0.885 29.883 69.270 1.00 10.88 C

ATOM 997 C GLY A 143 -2.183 30.540 68.811 1.00 11.27 C

ATOM 998 O GLY A 143 -3.260 29.946 68.931 1.00 11.40 O

ATOM 999 N SER A 144 -2.099 31.757 68.276 1.00 11.66 N

ATOM 1000 CA SER A 144 -3.282 32.424 67.717 1.00 12.01 C W2025-7029WO / AM102903-PCT

ATOM 1001 CB SER A 144 3.997 33.274 68.779 1.00 12.20 C

ATOM 1002 OG SER A 144 3.153 34.290 69.294 1.00 14.32 O

ATOM 1003 C SER A 144 2.929 33.244 66.470 1.00 11.89 C

ATOM 1004 O SER A 144 1.761 33.328 66.089 1.00 11.69 O

ATOM 1005 N ARG A 145 3.946 33.808 65.818 1.00 12.08 N

ATOM 1006 CA ARG A 145 3.747 34.594 64.589 1.00 12.18 C

ATOM 1007 CB ARG A 145 3.140 35.971 64.918 1.00 12.19 C

ATOM 1008 CG ARG A 145 3.989 36.806 65.873 1.00 11.86 C

ATOM 1009 CD ARG A 145 3.384 38.176 66.090 1.00 11.83 C

ATOM 1010 NE ARG A 145 3.639 39.080 64.970 1.00 11.72 N

ATOM 1011 CZ ARG A 145 2.729 39.894 64.435 1.00 11.72 C

ATOM 1012 NHl ARG A 145 3.073 40.695 63.433 1.00 12.68 N

ATOM 1013 NH2 ARG A 145 1.474 39.905 64.884 1.00 11.44 N

ATOM 1014 C ARG A 145 2.921 33.840 63.527 1.00 12.34 C

ATOM 1015 O ARG A 145 2.021 34.405 62.892 1.00 12.77 O

ATOM 1016 N GLY A 146 3.232 32.559 63.341 1.00 12.16 N

ATOM 1017 CA GLY A 146 2.555 31.737 62.334 1.00 12.19 C

ATOM 1018 C GLY A 146 1.433 30.861 62.869 1.00 12.06 C

ATOM 1019 O GLY A 146 1.023 29.894 62.215 1.00 12.37 O

ATOM 1020 N SER A 147 0.925 31.214 64.048 1.00 11.81 N

ATOM 1021 CA SER A 147 0.147 30.468 64.707 1.00 11.67 C

ATOM 1022 CB SER A 147 0.816 31.336 65.782 1.00 11.42 C

ATOM 1023 OG SER A 147 1.674 30.575 66.616 1.00 11.24 O

ATOM 1024 C SER A 147 0.398 29.170 65.309 1.00 11.63 C

ATOM 1025 O SER A 147 1.339 29.199 66.093 1.00 11.57 O

ATOM 1026 N PRO A 148 0.194 28.023 64.933 1.00 11.91 N

ATOM 1027 CA PRO A 148 0.305 26.710 65.369 1.00 12.27 C

ATOM 1028 CB PRO A 148 0.427 25.746 64.432 1.00 12.27 C

ATOM 1029 CG PRO A 148 1.711 26.438 64.145 1.00 12.09 C

ATOM 1030 CD PRO A 148 1.368 27.894 64.052 1.00 11.97 C

ATOM 1031 C PRO A 148 0.011 26.398 66.840 1.00 12.51 C

ATOM 1032 O PRO A 148 0.876 27.053 67.434 1.00 12.45 O

ATOM 1033 N PRO A 149 0.679 25.397 67.429 1.00 12.96 N

ATOM 1034 CA PRO A 149 0.582 25.149 68.880 1.00 12.89 C

ATOM 1035 CB PRO A 149 1.476 23.918 69.092 1.00 13.30 C

ATOM 1036 CG PRO A 149 2.395 23.909 67.912 1.00 13.20 C

ATOM 1037 CD PRO A 149 1.591 24.439 66.773 1.00 12.89 C

ATOM 1038 C PRO A 149 0.831 24.890 69.416 1.00 12.91 C

ATOM 1039 O PRO A 149 1.128 25.276 70.554 1.00 13.00 O

ATOM 1040 N GLN A 150 1.689 24.269 68.604 1.00 12.40 N

ATOM 1041 CA GLN A 150 3.063 23.947 69.013 1.00 12.48 C

ATOM 1042 CB GLN A 150 3.750 23.041 67.974 1.00 12.46 C

ATOM 1043 CG GLN A 150 3.988 23.670 66.604 1.00 13.03 C

ATOM 1044 CD GLN A 150 2.858 23.410 65.616 1.00 13.83 C

ATOM 1045 OEl GLN A 150 1.716 23.153 66.002 1.00 14.42 O

ATOM 1046 NE2 GLN A 150 3.178 23.484 64.327 1.00 14.00 N

ATOM 1047 C GLN A 150 3.922 25.188 69.293 1.00 11.94 C

ATOM 1048 O GLN A 150 4.945 25.101 69.976 1.00 12.17 O

ATOM 1049 N ASP A 151 3.495 26.335 68.764 1.00 11.53 N

ATOM 1050 CA ASP A 151 4.216 27.604 68.947 1.00 11.37 C

ATOM 1051 CB ASP A 151 3.660 28.671 68.003 1.00 11.37 C

ATOM 1052 CG ASP A 151 4.196 28.539 66.588 1.00 11.35 C

ATOM 1053 ODl ASP A 151 4.993 27.611 66.306 1.00 12.20 O

ATOM 1054 OD2 ASP A 151 3.809 29.374 65.747 1.00 11.88 O

ATOM 1055 C ASP A 151 4.214 28.126 70.384 1.00 11.25 C

ATOM 1056 O ASP A 151 5.095 28.898 70.763 1.00 10.97 O

ATOM 1057 N LYS A 152 3.224 27.705 71.171 1.00 10.99 N

ATOM 1058 CA LYS A 152 3.164 28.036 72.592 1.00 11.13 C

ATOM 1059 CB LYS A 152 1.928 27.404 73.242 1.00 11.39 C

ATOM 1060 CG LYS A 152 1.796 27.662 74.745 1.00 11.64 C

ATOM 1061 CD LYS A 152 0.497 27.087 75.280 1.00 12.58 C

ATOM 1062 CE LYS A 152 0.447 27.111 76.790 1.00 12.95 C

ATOM 1063 NZ LYS A 152 0.884 26.661 77.308 1.00 13.98 N W2025-7029WO / AM102903-PCT

ATOM 1064 C LYS A 152 4.441 27.553 73.271 1.00 11.04 C

ATOM 1065 O LYS A 152 5.137 28.328 73.926 1.00 11.13 O

ATOM 1066 N HIS A 153 4.758 26.274 73.087 1.00 10.76 N

ATOM 1067 CA HIS A 153 5.988 25.729 73.649 1.00 10.69 C

ATOM 1068 CB HIS A 153 5.957 24.202 73.677 1.00 10.60 C

ATOM 1069 CG HIS A 153 7.224 23.599 74.191 1.00 11.10 C

ATOM 1070 NDl HIS A 153 7.698 23.845 75.461 1.00 12.66 N

ATOM 1071 CEl HIS A 153 8.839 23.199 75.634 1.00 12.48 C

ATOM 1072 NE2 HIS A 153 9.123 22.550 74.521 1.00 11.62 N

ATOM 1073 CD2 HIS A 153 8.129 22.783 73.600 1.00 12.49 C

ATOM 1074 C HIS A 153 7.228 26.221 72.904 1.00 10.68 C

ATOM 1075 O HIS A 153 8.243 26.531 73.527 1.00 10.33 O

ATOM 1076 N LEU A 154 7.148 26.297 71.576 1.00 10.34 N

ATOM 1077 CA LEU A 154 8.302 26.743 70.792 1.00 10.22 C

ATOM 1078 CB LEU A 154 8.072 26.554 69.287 1.00 10.44 C

ATOM 1079 CG LEU A 154 8.176 25.105 68.782 1.00 11.58 C

ATOM 1080 CDl LEU A 154 7.696 24.999 67.338 1.00 11.64 C

ATOM 1081 CD2 LEU A 154 9.609 24.553 68.910 1.00 12.16 C

ATOM 1082 C LEU A 154 8.726 28.175 71.135 1.00 9.89 C

ATOM 1083 O LEU A 154 9.908 28.505 71.057 1.00 9.82 O

ATOM 1084 N PHE A 155 7.767 29.011 71.539 1.00 9.48 N

ATOM 1085 CA PHE A 155 8.094 30.353 72.022 1.00 9.46 C

ATOM 1086 CB PHE A 155 6.827 31.199 72.231 1.00 9.31 C

ATOM 1087 CG PHE A 155 7.101 32.626 72.633 1.00 10.31 C

ATOM 1088 CDl PHE A 155 7.883 33.456 71.832 1.00 10.26 C

ATOM 1089 CEl PHE A 155 8.141 34.785 72.208 1.00 10.27 C

ATOM 1090 CZ PHE A 155 7.596 35.291 73.386 1.00 9.87 C

ATOM 1091 CE2 PHE A 155 6.808 34.470 74.192 1.00 9.97 C

ATOM 1092 CD2 PHE A 155 6.566 33.144 73.811 1.00 10.62 C

ATOM 1093 C PHE A 155 8.959 30.303 73.291 1.00 9.29 C

ATOM 1094 O PHE A 155 9.943 31.035 73.394 1.00 9.48 O

ATOM 1095 N THR A 156 8.599 29.440 74.244 1.00 9.44 N

ATOM 1096 CA THR A 156 9.404 29.239 75.459 1.00 9.55 C

ATOM 1097 CB THR A 156 8.798 28.138 76.367 1.00 9.64 C

ATOM 1098 OGl THR A 156 7.416 28.422 76.620 1.00 10.03 O

ATOM 1099 CG2 THR A 156 9.562 28.033 77.688 1.00 10.05 C

ATOM 1100 C THR A 156 10.826 28.832 75.088 1.00 9.46 C

ATOM 1101 O THR A 156 11.806 29.375 75.614 1.00 8.97 O

ATOM 1102 N VAL A 157 10.922 27.870 74.172 1.00 9.26 N

ATOM 1103 CA VAL A 157 12.199 27.362 73.689 1.00 9.57 C

ATOM 1104 CB VAL A 157 11.990 26.182 72.704 1.00 9.59 C

ATOM 1105 CGl VAL A 157 13.286 25.820 71.998 1.00 9.37 C

ATOM 1106 CG2 VAL A 157 11.424 24.974 73.438 1.00 10.54 C

ATOM 1107 C VAL A 157 13.041 28.479 73.058 1.00 9.43 C

ATOM 1108 O VAL A 157 14.225 28.626 73.380 1.00 9.67 O

ATOM 1109 N LEU A 158 12.415 29.274 72.192 1.00 9.00 N

ATOM 1110 CA LEU A 158 13.073 30.415 71.546 1.00 8.92 C

ATOM 1111 CB LEU A 158 12.085 31.153 70.638 1.00 8.78 C

ATOM 1112 CG LEU A 158 12.558 32.492 70.053 1.00 9.27 C

ATOM 1113 CDl LEU A 158 13.668 32.289 69.013 1.00 11.03 C

ATOM 1114 CD2 LEU A 158 11.388 33.286 69.471 1.00 8.56 C

ATOM 1115 C LEU A 158 13.639 31.391 72.577 1.00 8.70 C

ATOM 1116 O LEU A 158 14.791 31.816 72.478 1.00 8.79 O

ATOM 1117 N VAL A 159 12.817 31.737 73.565 1.00 8.42 N

ATOM 1118 CA VAL A 159 13.205 32.712 74.579 1.00 8.35 C

ATOM 1119 CB VAL A 159 11.995 33.146 75.450 1.00 8.19 C

ATOM 1120 CGl VAL A 159 12.450 33.962 76.644 1.00 7.77 C

ATOM 1121 CG2 VAL A 159 11.002 33.955 74.620 1.00 7.58 C

ATOM 1122 C VAL A 159 14.360 32.182 75.441 1.00 8.63 C

ATOM 1123 O VAL A 159 15.321 32.910 75.715 1.00 8.66 O

ATOM 1124 N GLN A 160 14.261 30.920 75.851 1.00 9.16 N

ATOM 1125 CA GLN A 160 15.325 30.291 76.631 1.00 9.77 C

ATOM 1126 CB GLN A 160 14.959 28.875 77.064 1.00 10.18 C W2025-7029WO / AM102903-PCT

ATOM 1127 CG GLN A 160 16.090 28.225 77.869 1.00 11.21 C

ATOM 1128 CD GLN A 160 15.729 26.891 78.487 1.00 13.91 C

ATOM 1129 OEl GLN A 160 14.667 26.326 78.220 1.00 14.92 O

ATOM 1130 NE2 GLN A 160 16.622 26.379 79.330 1.00 14.74 N

ATOM 1131 C GLN A 160 16.643 30.271 75.857 1.00 9.64 C

ATOM 1132 O GLN A 160 17.682 30.646 76.397 1.00 9.70 O

ATOM 1133 N GLU A 161 16.586 29.839 74.597 1.00 9.51 N

ATOM 1134 CA GLU A 161 17.779 29.785 73.749 1.00 9.94 C

ATOM 1135 CB GLU A 161 17.463 29.116 72.407 1.00 10.04 C

ATOM 1136 CG GLU A 161 17.153 27.631 72.563 1.00 10.58 C

ATOM 1137 CD GLU A 161 16.760 26.945 71.266 1.00 11.31 C

ATOM 1138 OEl GLU A 161 16.609 27.634 70.232 1.00 11.30 O

ATOM 1139 OE2 GLU A 161 16.594 25.704 71.295 1.00 12.78 O

ATOM 1140 C GLU A 161 18.400 31.163 73.555 1.00 10.06 C

ATOM 1141 O GLU A 161 19.627 31.302 73.581 1.00 10.57 O

ATOM 1142 N MET A 162 17.556 32.182 73.389 1.00 10.07 N

ATOM 1143 CA AMET A 162 18.025 33.561 73.254 0.50 9.94 C

ATOM 1144 CA BMET A 162 18.050 33.542 73.254 0.50 9.98 C

ATOM 1145 CB AMET A 162 16.859 34.488 72.894 0.50 10.03 C

ATOM 1146 CB BMET A 162 16.937 34.493 72.845 0.50 10.09 C

ATOM 1147 CG AMET A 162 17.261 35.934 72.587 0.50 10.01 C

ATOM 1148 CG BMET A 162 17.405 35.929 72.829 0.50 10.11 C

ATOM 1149 SD AMET A 162 18.009 36.173 70.958 0.50 10.19

ATOM 1150 SD BMET A 162 16.369 36.988 71.840 0.50 10.58

ATOM 1151 CE AMET A 162 16.595 35.907 69.889 0.50 10.28 C

ATOM 1152 CE BMET A 162 16.685 36.348 70.192 0.50 11.29 C

ATOM 1153 C MET A 162 18.704 34.036 74.542 1.00 10.02 C

ATOM 1154 O MET A 162 19.792 34.613 74.504 1.00 9.86 O

ATOM 1155 N ARG A 163 18.038 33.806 75.674 1.00 10.03 N

ATOM 1156 CA ARG A 163 18.563 34.192 76.981 1.00 10.33 C

ATOM 1157 CB ARG A 163 17.583 33.796 78.098 1.00 10.27 C

ATOM 1158 CG ARG A 163 18.112 33.960 79.526 1.00 10.93 C

ATOM 1159 CD ARG A 163 18.410 35.411 79.860 1.00 11.33 C

ATOM 1160 NE ARG A 163 18.962 35.550 81.206 1.00 12.41 N

ATOM 1161 CZ ARG A 163 18.251 35.883 82.280 1.00 14.69 C

ATOM 1162 NHl ARG A 163 18.849 35.979 83.461 1.00 16.44 N

ATOM 1163 NH2 ARG A 163 16.946 36.123 82.181 1.00 15.70 N

ATOM 1164 C ARG A 163 19.937 33.556 77.196 1.00 10.30 C

ATOM 1165 O ARG A 163 20.886 34.236 77.590 1.00 10.71 O

ATOM 1166 N GLU A 164 20.045 32.263 76.902 1.00 10.54 N

ATOM 1167 CA GLU A 164 21.297 31.536 77.118 1.00 11.06 C

ATOM 1168 CB GLU A 164 21.057 30.025 77.104 1.00 11.47 C

ATOM 1169 CG GLU A 164 20.223 29.566 78.304 1.00 12.30 C

ATOM 1170 CD GLU A 164 20.062 28.062 78.402 1.00 14.61 C

ATOM 1171 OEl GLU A 164 19.444 27.604 79.388 1.00 16.50 O

ATOM 1172 OE2 GLU A 164 20.540 27.336 77.502 1.00 17.55 O

ATOM 1173 C GLU A 164 22.392 31.971 76.138 1.00 10.92 C

ATOM 1174 O GLU A 164 23.554 32.105 76.525 1.00 10.78 O

ATOM 1175 N ALA A 165 22.009 32.235 74.889 1.00 10.59 N

ATOM 1176 CA ALA A 165 22.933 32.811 73.908 1.00 10.62 C

ATOM 1177 CB ALA A 165 22.277 32.914 72.545 1.00 10.78 C

ATOM 1178 C ALA A 165 23.446 34.178 74.367 1.00 10.63 C

ATOM 1179 O ALA A 165 24.643 34.466 74.246 1.00 10.79 O

ATOM 1180 N PHE A 166 22.541 35.008 74.896 1.00 10.28 N

ATOM 1181 CA PHE A 166 22.904 36.313 75.459 1.00 10.58 C

ATOM 1182 CB PHE A 166 21.653 37.100 75.889 1.00 10.14 C

ATOM 1183 CG PHE A 166 20.870 37.710 74.737 1.00 9.28 C

ATOM 1184 CDl PHE A 166 21.298 37.595 73.412 1.00 9.20 C

ATOM 1185 CEl PHE A 166 20.572 38.174 72.369 1.00 8.91 C

ATOM 1186 CZ PHE A 166 19.414 38.897 72.650 1.00 9.32 C

ATOM 1187 CE2 PHE A 166 18.989 39.029 73.964 1.00 8.55 C

ATOM 1188 CD2 PHE A 166 19.713 38.438 74.996 1.00 8.52 C

ATOM 1189 C PHE A 166 23.873 36.190 76.638 1.00 10.98 C W2025-7029WO / AM102903-PCT

ATOM 1190 O PHE A 166 24.835 36.953 76.735 1.00 11.22 O

ATOM 1191 N GLU A 167 23.618 35.231 77.529 1.00 11.69 N

ATOM 1192 CA GLU A 167 24.506 34.976 78.672 1.00 12.55 C

ATOM 1193 CB GLU A 167 23.933 33.874 79.576 1.00 12.63 C

ATOM 1194 CG GLU A 167 22.686 34.312 80.356 1.00 14.28 C

ATOM 1195 CD GLU A 167 22.007 33.189 81.125 1.00 16.55 C

ATOM 1196 OEl GLU A 167 22.309 31.995 80.878 1.00 19.28 O

ATOM 1197 OE2 GLU A 167 21.154 33.510 81.986 1.00 19.55 O

ATOM 1198 C GLU A 167 25.916 34.610 78.200 1.00 12.71 C

ATOM 1199 O GLU A 167 26.909 35.146 78.701 1.00 12.80 O

ATOM 1200 N GLN A 168 25.990 33.713 77.221 1.00 13.22 N

ATOM 1201 CA GLN A 168 27.275 33.248 76.692 1.00 13.77 C

ATOM 1202 CB GLN A 168 27.077 32.030 75.785 1.00 14.26 C

ATOM 1203 CG GLN A 168 26.546 30.783 76.505 1.00 17.53 C

ATOM 1204 CD GLN A 168 27.550 30.137 77.462 1.00 22.37 C

ATOM 1205 OEl GLN A 168 28.738 30.486 77.484 1.00 25.02 O

ATOM 1206 NE2 GLN A 168 27.071 29.180 78.256 1.00 24.14 N

ATOM 1207 C GLN A 168 28.035 34.359 75.958 1.00 13.62 C

ATOM 1208 O GLN A 168 29.253 34.511 76.130 1.00 13.60 O

ATOM 1209 N GLU A 169 27.314 35.147 75.159 1.00 13.07 N

ATOM 1210 CA GLU A 169 27.928 36.253 74.424 1.00 13.13 C

ATOM 1211 CB GLU A 169 26.939 36.882 73.438 1.00 13.00 C

ATOM 1212 CG GLU A 169 27.563 37.917 72.488 1.00 13.05 C

ATOM 1213 CD GLU A 169 27.368 39.358 72.940 1.00 13.82 C

ATOM 1214 OEl GLU A 169 26.969 39.590 74.102 1.00 12.54 O

ATOM 1215 OE2 GLU A 169 27.609 40.265 72.116 1.00 14.38 O

ATOM 1216 C GLU A 169 28.506 37.313 75.360 1.00 13.11 C

ATOM 1217 O GLU A 169 29.594 37.837 75.113 1.00 13.07 O

ATOM 1218 N ALA A 170 27.775 37.620 76.430 1.00 13.24 N

ATOM 1219 CA ALA A 170 28.203 38.633 77.395 1.00 13.84 C

ATOM 1220 CB ALA A 170 27.196 38.734 78.525 1.00 13.66 C

ATOM 1221 C ALA A 170 29.592 38.316 77.947 1.00 14.38 C

ATOM 1222 O ALA A 170 30.434 39.207 78.094 1.00 14.59 O

ATOM 1223 N LYS A 171 29.822 37.040 78.239 1.00 15.38 N

ATOM 1224 CA LYS A 171 31.094 36.586 78.801 1.00 16.43 C

ATOM 1225 CB LYS A 171 30.920 35.238 79.493 1.00 16.63 C

ATOM 1226 CG LYS A 171 30.159 35.337 80.797 1.00 18.11 C

ATOM 1227 CD LYS A 171 30.251 34.049 81.583 1.00 20.00 C

ATOM 1228 CE LYS A 171 29.782 34.270 83.008 1.00 21.32 C

ATOM 1229 NZ LYS A 171 30.061 33.091 83.862 1.00 22.50 N

ATOM 1230 C LYS A 171 32.212 36.514 77.764 1.00 16.84 C

ATOM 1231 O LYS A 171 33.374 36.770 78.090 1.00 16.98 O

ATOM 1232 N GLN A 172 31.870 36.181 76.521 1.00 17.10 N

ATOM 1233 CA GLN A 172 32.892 36.068 75.472 1.00 17.63 C

ATOM 1234 CB GLN A 172 32.399 35.247 74.266 1.00 18.05 C

ATOM 1235 CG GLN A 172 31.327 35.899 73.405 1.00 20.07 C

ATOM 1236 CD GLN A 172 30.691 34.934 72.405 1.00 21.19 C

ATOM 1237 OEl GLN A 172 30.444 35.297 71.253 1.00 23.29 O

ATOM 1238 NE2 GLN A 172 30.423 33.709 72.844 1.00 22.40 N

ATOM 1239 C GLN A 172 33.456 37.426 75.051 1.00 17.23 C

ATOM 1240 O GLN A 172 34.630 37.522 74.691 1.00 17.54 O

ATOM 1241 N ILE A 173 32.630 38.470 75.128 1.00 16.51 N

ATOM 1242 CA ILE A 173 33.055 39.824 74.763 1.00 15.98 C

ATOM 1243 CB ILE A 173 32.086 40.494 73.739 1.00 16.17 C

ATOM 1244 CGl ILE A 173 30.776 40.927 74.408 1.00 15.70 C

ATOM 1245 CDl ILE A 173 29.996 41.977 73.617 1.00 16.30 C

ATOM 1246 CG2 ILE A 173 31.843 39.571 72.524 1.00 16.31 C

ATOM 1247 C ILE A 173 33.276 40.738 75.980 1.00 15.68 C

ATOM 1248 O ILE A 173 33.689 41.893 75.829 1.00 15.54 O

ATOM 1249 N ASN A 174 33.012 40.206 77.176 1.00 15.27 N

ATOM 1250 CA ASN A 174 33.207 40.935 78.436 1.00 15.08 C

ATOM 1251 CB ASN A 174 34.705 41.139 78.722 1.00 15.36 C

ATOM 1252 CG ASN A 174 34.975 41.645 80.131 1.00 16.50 C W2025-7029WO / AM102903-PCT

ATOM 1253 ODl ASN A 174 34.193 41.406 81.055 1.00 17.01 O

ATOM 1254 ND2 ASN A 174 36.092 42.351 80.301 1.00 17.37 N

ATOM 1255 C ASN A 174 32.426 42.260 78.503 1.00 14.56 C

ATOM 1256 O ASN A 174 32.976 43.318 78.830 1.00 14.39 O

ATOM 1257 N LYS A 175 31.138 42.191 78.179 1.00 13.95 N

ATOM 1258 CA LYS A 175 30.251 43.350 78.272 1.00 13.60 C

ATOM 1259 CB LYS A 175 29.920 43.903 76.877 1.00 14.05 C

ATOM 1260 CG LYS A 175 31.130 44.476 76.136 1.00 15.32 C

ATOM 1261 CD LYS A 175 30.737 45.569 75.160 1.00 19.63 C

ATOM 1262 CE LYS A 175 31.973 46.233 74.555 1.00 21.19 C

ATOM 1263 NZ LYS A 175 31.613 47.298 73.568 1.00 23.14 N

ATOM 1264 C LYS A 175 28.977 42.939 78.999 1.00 12.97 C

ATOM 1265 O LYS A 175 28.686 41.750 79.084 1.00 12.85 O

ATOM 1266 N PRO A 176 28.223 43.913 79.544 1.00 12.52 N

ATOM 1267 CA PRO A 176 26.921 43.567 80.121 1.00 12.17 C

ATOM 1268 CB PRO A 176 26.306 44.930 80.440 1.00 11.94 C

ATOM 1269 CG PRO A 176 27.492 45.817 80.687 1.00 12.51 C

ATOM 1270 CD PRO A 176 28.528 45.349 79.700 1.00 12.73 C

ATOM 1271 C PRO A 176 26.030 42.785 79.155 1.00 11.85 C

ATOM 1272 O PRO A 176 26.020 43.050 77.946 1.00 11.75 O

ATOM 1273 N ARG A 177 25.298 41.822 79.710 1.00 11.65 N

ATOM 1274 CA ARG A 177 24.428 40.942 78.947 1.00 11.49 C

ATOM 1275 CB ARG A 177 23.868 39.860 79.879 1.00 11.44 C

ATOM 1276 CG ARG A 177 22.839 38.963 79.235 1.00 11.99 C

ATOM 1277 CD ARG A 177 22.323 37.879 80.165 1.00 10.92 C

ATOM 1278 NE ARG A 177 21.517 38.335 81.304 1.00 10.91 N

ATOM 1279 CZ ARG A 177 20.257 38.772 81.242 1.00 11.59 C

ATOM 1280 NHl ARG A 177 19.620 38.884 80.078 1.00 10.37 N

ATOM 1281 NH2 ARG A 177 19.628 39.114 82.361 1.00 11.14 N

ATOM 1282 C ARG A 177 23.277 41.705 78.293 1.00 11.07 C

ATOM 1283 O ARG A 177 22.667 42.567 78.920 1.00 11.10 O

ATOM 1284 N LEU A 178 22.985 41.368 77.036 1.00 10.95 N

ATOM 1285 CA LEU A 178 21.804 41.887 76.351 1.00 10.53 C

ATOM 1286 CB LEU A 178 21.781 41.423 74.891 1.00 10.57 C

ATOM 1287 CG LEU A 178 22.850 41.996 73.957 1.00 9.75 C

ATOM 1288 CDl LEU A 178 22.925 41.148 72.690 1.00 10.57 C

ATOM 1289 CD2 LEU A 178 22.562 43.456 73.634 1.00 11.16 C

ATOM 1290 C LEU A 178 20.548 41.383 77.057 1.00 10.47 C

ATOM 1291 O LEU A 178 20.501 40.239 77.518 1.00 10.32 O

ATOM 1292 N MET A 179 19.536 42.241 77.138 1.00 10.36 N

ATOM 1293 CA MET A 179 18.266 41.869 77.754 1.00 10.78 C

ATOM 1294 CB MET A 179 17.559 43.103 78.317 1.00 10.76 C

ATOM 1295 CG MET A 179 18.224 43.710 79.551 1.00 12.43 C

ATOM 1296 SD MET A 179 17.448 45.270 80.026 1.00 16.11 S

ATOM 1297 CE MET A 179 18.181 46.380 78.840 1.00 16.31 C

ATOM 1298 C MET A 179 17.357 41.177 76.749 1.00 10.43 C

ATOM 1299 O MET A 179 17.442 41.421 75.543 1.00 10.45 O

ATOM 1300 N VAL A 180 16.498 40.300 77.256 1.00 10.13 N

ATOM 1301 CA VAL A 180 15.422 39.726 76.449 1.00 9.92 C

ATOM 1302 CB VAL A 180 15.674 38.233 76.056 1.00 9.90 C

ATOM 1303 CGl VAL A 180 15.811 37.342 77.286 1.00 10.26 C

ATOM 1304 CG2 VAL A 180 14.574 37.711 75.123 1.00 10.30 C

ATOM 1305 C VAL A 180 14.107 39.932 77.198 1.00 9.56 C

ATOM 1306 O VAL A 180 13.957 39.535 78.357 1.00 9.95 O

ATOM 1307 N THR A 181 13.182 40.613 76.535 1.00 9.17 N

ATOM 1308 CA THR A 181 11.883 40.931 77.111 1.00 8.49 C

ATOM 1309 CB THR A 181 11.769 42.439 77.461 1.00 8.49 C

ATOM 1310 OGl THR A 181 11.780 43.220 76.262 1.00 7.66 O

ATOM 1311 CG2 THR A 181 12.925 42.888 78.371 1.00 7.33 C

ATOM 1312 C THR A 181 10.811 40.534 76.107 1.00 8.47 C

ATOM 1313 O THR A 181 11.128 40.189 74.968 1.00 8.28 O

ATOM 1314 N ALA A 182 9.548 40.568 76.524 1.00 8.25 N

ATOM 1315 CA ALA A 182 8.449 40.265 75.605 1.00 7.97 C W2025-7029WO / AM102903-PCT

ATOM 1316 CB ALA A 182 8.123 38.765 75.615 1.00 8.11 C

ATOM 1317 C ALA A 182 7.205 41.069 75.933 1.00 7.87 C

ATOM 1318 O ALA A 182 6.843 41.203 77.104 1.00 8.16 O

ATOM 1319 N ALA A 183 6.570 41.601 74.891 1.00 7.49 N

ATOM 1320 CA ALA A 183 5.240 42.189 75.001 1.00 7.32 C

ATOM 1321 CB ALA A 183 5.028 43.258 73.942 1.00 7.08 C

ATOM 1322 C ALA A 183 4.229 41.058 74.846 1.00 7.56 C

ATOM 1323 O ALA A 183 4.319 40.261 73.907 1.00 7.77 O

ATOM 1324 N VAL A 184 3.283 40.978 75.776 1.00 7.79 N

ATOM 1325 CA VAL A 184 2.418 39.802 75.868 1.00 8.05 C

ATOM 1326 CB VAL A 184 2.781 38.920 77.094 1.00 8.16 C

ATOM 1327 CGl VAL A 184 4.213 38.373 76.982 1.00 8.36 C

ATOM 1328 CG2 VAL A 184 2.590 39.691 78.391 1.00 7.82 C

ATOM 1329 C VAL A 184 0.935 40.154 75.923 1.00 8.31 C

ATOM 1330 O VAL A 184 0.557 41.266 76.306 1.00 8.13 O

ATOM 1331 N ALA A 185 0.108 39.177 75.557 1.00 8.66 N

ATOM 1332 CA ALA A 185 -1.338 39.356 75.465 1.00 8.79 C

ATOM 1333 CB ALA A 185 -1.969 38.116 74.875 1.00 9.00 C

ATOM 1334 C ALA A 185 -2.001 39.690 76.798 1.00 8.78 C

ATOM 1335 O ALA A 185 -1.546 39.246 77.869 1.00 8.36 O

ATOM 1336 N ALA A 186 -3.090 40.454 76.709 1.00 9.12 N

ATOM 1337 CA ALA A 186 -3.957 40.730 77.859 1.00 9.37 C

ATOM 1338 CB ALA A 186 -4.297 42.210 77.933 1.00 9.69 C

ATOM 1339 C ALA A 186 -5.241 39.897 77.827 1.00 9.74 C

ATOM 1340 O ALA A 186 -5.890 39.720 78.860 1.00 10.03 O

ATOM 1341 N GLY A 187 -5.606 39.407 76.641 1.00 9.87 N

ATOM 1342 CA GLY A 187 -6.796 38.565 76.469 1.00 10.26 C

ATOM 1343 C GLY A 187 -6.587 37.171 77.029 1.00 10.56 C

ATOM 1344 O GLY A 187 -5.612 36.497 76.687 1.00 10.36 O

ATOM 1345 N ILE A 188 -7.508 36.725 77.878 1.00 10.79 N

ATOM 1346 CA ILE A 188 -7.324 35.460 78.596 1.00 11.47 C

ATOM 1347 CB ILE A 188 -8.426 35.218 79.669 1.00 11.43 C

ATOM 1348 CGl ILE A 188 -8.508 36.406 80.649 1.00 11.55 C

ATOM 1349 CDl ILE A 188 -7.179 36.828 81.301 1.00 12.67 C

ATOM 1350 CG2 ILE A 188 -8.180 33.906 80.419 1.00 12.20 C

ATOM 1351 C ILE A 188 -7.163 34.264 77.651 1.00 11.67 C

ATOM 1352 O ILE A 188 -6.252 33.451 77.838 1.00 11.51 O

ATOM 1353 N SER A 189 -8.024 34.170 76.636 1.00 11.90 N

ATOM 1354 CA SER A 189 -7.914 33.108 75.626 1.00 12.69 C

ATOM 1355 CB SER A 189 -9.031 33.226 74.586 1.00 12.77 C

ATOM 1356 OG SER A 189 10.299 33.013 75.190 1.00 16.89 O

ATOM 1357 C SER A 189 -6.553 33.111 74.934 1.00 12.19 C

ATOM 1358 O SER A 189 -5.939 32.052 74.759 1.00 12.69 O

ATOM 1359 N ASN A 190 -6.084 34.301 74.559 1.00 11.90 N

ATOM 1360 CA ASN A 190 -4.765 34.463 73.939 1.00 11.66 C

ATOM 1361 CB ASN A 190 -4.577 35.897 73.436 1.00 11.89 C

ATOM 1362 CG ASN A 190 -5.482 36.230 72.256 1.00 12.59 C

ATOM 1363 ODl ASN A 190 -5.970 35.341 71.547 1.00 14.61 O

ATOM 1364 ND2 ASN A 190 -5.694 37.519 72.030 1.00 14.04 N

ATOM 1365 C ASN A 190 -3.604 34.049 74.858 1.00 11.21 C

ATOM 1366 O ASN A 190 -2.640 33.428 74.407 1.00 10.48 O

ATOM 1367 N ILE A 191 -3.709 34.402 76.138 1.00 10.68 N

ATOM 1368 CA ILE A 191 -2.708 34.016 77.141 1.00 10.56 C

ATOM 1369 CB ILE A 191 -2.993 34.658 78.522 1.00 10.53 C

ATOM 1370 CGl ILE A 191 -2.941 36.189 78.424 1.00 9.38 C

ATOM 1371 CDl ILE A 191 -3.560 36.917 79.601 1.00 9.35 C

ATOM 1372 CG2 ILE A 191 -1.989 34.162 79.565 1.00 9.60 C

ATOM 1373 C ILE A 191 -2.646 32.493 77.286 1.00 11.17 C

ATOM 1374 O ILE A 191 -1.566 31.903 77.275 1.00 11.37 O

ATOM 1375 N GLN A 192 -3.816 31.867 77.411 1.00 11.78 N

ATOM 1376 CA GLN A 192 -3.905 30.413 77.598 1.00 12.64 C

ATOM 1377 CB GLN A 192 -5.345 30.005 77.934 1.00 12.93 C

ATOM 1378 CG GLN A 192 -5.773 30.467 79.320 1.00 14.07 C W2025-7029WO / AM102903-PCT

ATOM 1379 CD GLN A 192 -7.233 30.205 79.628 1.00 16.19 C

ATOM 1380 OEl GLN A 192 -8.032 29.917 78.737 1.00 18.01 O

ATOM 1381 NE2 GLN A 192 -7.592 30.323 80.904 1.00 17.00 N

ATOM 1382 C GLN A 192 -3.362 29.598 76.424 1.00 12.63 C

ATOM 1383 O GLN A 192 -2.708 28.576 76.628 1.00 12.85 O

ATOM 1384 N SER A 193 -3.612 30.056 75.202 1.00 12.43 N

ATOM 1385 CA SER A 193 -3.108 29.356 74.025 1.00 12.41 C

ATOM 1386 CB SER A 193 -4.072 29.508 72.845 1.00 12.64 C

ATOM 1387 OG SER A 193 -4.150 30.853 72.417 1.00 14.30 O

ATOM 1388 C SER A 193 -1.695 29.791 73.631 1.00 11.80 C

ATOM 1389 O SER A 193 -1.077 29.186 72.753 1.00 11.68 O

ATOM 1390 N GLY A 194 -1.184 30.826 74.295 1.00 11.41 N

ATOM 1391 CA GLY A 194 0.055 31.467 73.867 1.00 11.35 C

ATOM 1392 C GLY A 194 1.302 31.227 74.698 1.00 11.00 C

ATOM 1393 O GLY A 194 2.402 31.155 74.146 1.00 10.65 O

ATOM 1394 N TYR A 195 1.147 31.117 76.017 1.00 10.64 N

ATOM 1395 CA TYR A 195 2.309 31.181 76.908 1.00 10.87 C

ATOM 1396 CB TYR A 195 2.393 32.555 77.583 1.00 10.86 C

ATOM 1397 CG TYR A 195 2.165 33.725 76.652 1.00 10.94 C

ATOM 1398 CDl TYR A 195 0.928 34.365 76.601 1.00 11.90 C

ATOM 1399 CEl TYR A 195 0.707 35.445 75.749 1.00 11.09 C

ATOM 1400 CZ TYR A 195 1.735 35.901 74.941 1.00 11.45 C

ATOM 1401 OH TYR A 195 1.506 36.967 74.105 1.00 10.29 O

ATOM 1402 CE2 TYR A 195 2.978 35.280 74.967 1.00 11.08 C

ATOM 1403 CD2 TYR A 195 3.189 34.202 75.827 1.00 10.84 C

ATOM 1404 C TYR A 195 2.362 30.098 77.976 1.00 11.11 C

ATOM 1405 O TYR A 195 1.356 29.804 78.635 1.00 11.22 O

ATOM 1406 N GLU A 196 3.549 29.515 78.132 1.00 11.44 N

ATOM 1407 CA GLU A 196 3.872 28.673 79.279 1.00 11.37 C

ATOM 1408 CB GLU A 196 4.851 27.562 78.884 1.00 11.65 C

ATOM 1409 CG GLU A 196 4.321 26.639 77.791 1.00 12.25 C

ATOM 1410 CD GLU A 196 5.325 25.585 77.337 1.00 12.74 C

ATOM 1411 OEl GLU A 196 4.895 24.443 77.065 1.00 14.57 O

ATOM 1412 OE2 GLU A 196 6.530 25.892 77.245 1.00 12.43 O

ATOM 1413 C GLU A 196 4.470 29.615 80.324 1.00 11.36 C

ATOM 1414 O GLU A 196 5.689 29.824 80.378 1.00 11.30 O

ATOM 1415 N ILE A 197 3.590 30.195 81.138 1.00 11.07 N

ATOM 1416 CA ILE A 197 3.935 31.343 81.987 1.00 11.37 C

ATOM 1417 CB ILE A 197 2.684 31.944 82.709 1.00 11.09 C

ATOM 1418 CGl ILE A 197 1.638 32.405 81.681 1.00 11.09 C

ATOM 1419 CDl ILE A 197 0.316 32.880 82.283 1.00 11.63 C

ATOM 1420 CG2 ILE A 197 3.091 33.100 83.622 1.00 11.94 C

ATOM 1421 C ILE A 197 5.113 31.133 82.961 1.00 11.59 C

ATOM 1422 O ILE A 197 6.048 31.934 82.968 1.00 11.44 O

ATOM 1423 N PRO A 198 5.088 30.050 83.769 1.00 11.99 N

ATOM 1424 CA PRO A 198 6.196 29.879 84.716 1.00 12.42 C

ATOM 1425 CB PRO A 198 5.811 28.607 85.483 1.00 12.46 C

ATOM 1426 CG PRO A 198 4.362 28.443 85.265 1.00 12.43 C

ATOM 1427 CD PRO A 198 4.107 28.958 83.886 1.00 12.20 C

ATOM 1428 C PRO A 198 7.544 29.697 84.013 1.00 12.82 C

ATOM 1429 O PRO A 198 8.547 30.275 84.440 1.00 12.57 O

ATOM 1430 N GLN A 199 7.554 28.920 82.935 1.00 13.41 N

ATOM 1431 CA GLN A 199 8.790 28.601 82.220 1.00 14.19 C

ATOM 1432 CB GLN A 199 8.572 27.442 81.235 1.00 14.37 C

ATOM 1433 CG GLN A 199 8.291 26.079 81.887 1.00 15.65 C

ATOM 1434 CD GLN A 199 6.876 25.940 82.447 1.00 17.70 C

ATOM 1435 OEl GLN A 199 5.944 26.630 82.019 1.00 16.59 O

ATOM 1436 NE2 GLN A 199 6.713 25.039 83.413 1.00 19.59 N

ATOM 1437 C GLN A 199 9.314 29.835 81.494 1.00 14.38 C

ATOM 1438 O GLN A 199 10.486 30.190 81.613 1.00 14.43 O

ATOM 1439 N LEU A 200 8.424 30.502 80.766 1.00 14.72 N

ATOM 1440 CA LEU A 200 8.766 31.721 80.048 1.00 15.35 C

ATOM 1441 CB LEU A 200 7.518 32.242 79.332 1.00 15.50 C W2025-7029WO / AM102903-PCT

ATOM 1442 CG LEU A 200 7.612 33.333 78.274 1.00 16.38 C

ATOM 1443 CDl LEU A 200 8.516 32.916 77.120 1.00 16.56 C

ATOM 1444 CD2 LEU A 200 6.214 33.667 77.775 1.00 15.97 C

ATOM 1445 C LEU A 200 9.329 32.774 81.006 1.00 15.55 C

ATOM 1446 O LEU A 200 10.370 33.393 80.738 1.00 15.50 O

ATOM 1447 N SER A 201 8.647 32.950 82.137 1.00 15.71 N

ATOM 1448 CA SER A 201 9.030 33.946 83.137 1.00 16.27 C

ATOM 1449 CB SER A 201 8.022 33.960 84.286 1.00 16.17 C

ATOM 1450 OG SER A 201 6.743 34.318 83.801 1.00 17.54 O

ATOM 1451 C SER A 201 10.452 33.788 83.684 1.00 16.29 C

ATOM 1452 O SER A 201 11.061 34.769 84.105 1.00 17.02 O

ATOM 1453 N GLN A 202 10.974 32.563 83.668 1.00 16.15 N

ATOM 1454 CA GLN A 202 12.324 32.287 84.165 1.00 16.23 C

ATOM 1455 CB GLN A 202 12.567 30.775 84.248 1.00 16.58 C

ATOM 1456 CG GLN A 202 13.818 30.392 85.026 1.00 19.05 C

ATOM 1457 CD GLN A 202 14.053 28.889 85.097 1.00 21.21 C

ATOM 1458 OEl GLN A 202 13.150 28.083 84.843 1.00 23.07 O

ATOM 1459 NE2 GLN A 202 15.279 28.506 85.443 1.00 23.80 N

ATOM 1460 C GLN A 202 13.416 32.937 83.312 1.00 15.49 C

ATOM 1461 O GLN A 202 14.472 33.313 83.828 1.00 15.27 O

ATOM 1462 N TYR A 203 13.160 33.061 82.011 1.00 14.72 N

ATOM 1463 CA TYR A 203 14.189 33.509 81.069 1.00 14.31 C

ATOM 1464 CB TYR A 203 14.291 32.540 79.884 1.00 14.81 C

ATOM 1465 CG TYR A 203 14.447 31.113 80.350 1.00 16.36 C

ATOM 1466 CDl TYR A 203 13.371 30.222 80.302 1.00 17.18 C

ATOM 1467 CEl TYR A 203 13.504 28.912 80.753 1.00 18.37 C

ATOM 1468 CZ TYR A 203 14.717 28.495 81.275 1.00 18.51 C

ATOM 1469 OH TYR A 203 14.860 27.201 81.720 1.00 20.55 O

ATOM 1470 CE2 TYR A 203 15.795 29.364 81.340 1.00 18.82 C

ATOM 1471 CD2 TYR A 203 15.651 30.668 80.883 1.00 17.18 C

ATOM 1472 C TYR A 203 14.030 34.949 80.600 1.00 13.42 C

ATOM 1473 O TYR A 203 15.002 35.568 80.177 1.00 13.72 O

ATOM 1474 N LEU A 204 12.816 35.483 80.688 1.00 12.54 N

ATOM 1475 CA LEU A 204 12.583 36.883 80.342 1.00 11.45 C

ATOM 1476 CB LEU A 204 11.100 37.136 80.064 1.00 11.32 C

ATOM 1477 CG LEU A 204 10.478 36.513 78.813 1.00 10.41 C

ATOM 1478 CDl LEU A 204 8.973 36.665 78.885 1.00 10.95 C

ATOM 1479 CD2 LEU A 204 11.022 37.180 77.549 1.00 10.94 C

ATOM 1480 C LEU A 204 13.058 37.811 81.455 1.00 10.72 C

ATOM 1481 O LEU A 204 12.859 37.528 82.635 1.00 10.74 O

ATOM 1482 N ASP A 205 13.676 38.923 81.069 1.00 10.10 N

ATOM 1483 CA ASP A 205 14.039 39.971 82.017 1.00 9.67 C

ATOM 1484 CB ASP A 205 15.064 40.917 81.383 1.00 9.78 C

ATOM 1485 CG ASP A 205 16.427 40.278 81.246 1.00 10.86 C

ATOM 1486 ODl ASP A 205 17.014 39.912 82.289 1.00 12.31 O

ATOM 1487 OD2 ASP A 205 16.909 40.141 80.102 1.00 10.70 O

ATOM 1488 C ASP A 205 12.813 40.752 82.476 1.00 9.39 C

ATOM 1489 O ASP A 205 12.685 41.089 83.657 1.00 9.70 O

ATOM 1490 N TYR A 206 11.933 41.057 81.527 1.00 9.07 N

ATOM 1491 CA TYR A 206 10.690 41.783 81.801 1.00 8.98 C

ATOM 1492 CB TYR A 206 10.859 43.287 81.567 1.00 9.66 C

ATOM 1493 CG TYR A 206 11.861 43.921 82.492 1.00 10.83 C

ATOM 1494 CDl TYR A 206 13.137 44.251 82.041 1.00 12.65 C

ATOM 1495 CEl TYR A 206 14.072 44.815 82.895 1.00 13.99 C

ATOM 1496 CZ TYR A 206 13.730 45.057 84.215 1.00 14.77 C

ATOM 1497 OH TYR A 206 14.650 45.617 85.069 1.00 16.19 O

ATOM 1498 CE2 TYR A 206 12.471 44.735 84.690 1.00 13.53 C

ATOM 1499 CD2 TYR A 206 11.545 44.167 83.827 1.00 12.91 C

ATOM 1500 C TYR A 206 9.569 41.259 80.927 1.00 8.49 C

ATOM 1501 O TYR A 206 9.806 40.801 79.805 1.00 7.99 O

ATOM 1502 N ILE A 207 8.353 41.356 81.455 1.00 7.95 N

ATOM 1503 CA ILE A 207 7.140 40.921 80.777 1.00 7.87 C

ATOM 1504 CB ILE A 207 6.390 39.834 81.599 1.00 8.09 C W2025-7029WO / AM102903-PCT

ATOM 1505 CGl ILE A 207 7.299 38.623 81.868 1.00 8.93 C

ATOM 1506 CDl ILE A 207 6.781 37.673 82.959 1.00 8.93 C

ATOM 1507 CG2 ILE A 207 5.098 39.416 80.900 1.00 7.39 C

ATOM 1508 C ILE A 207 6.270 42.162 80.609 1.00 7.76 C

ATOM 1509 O ILE A 207 5.731 42.693 81.592 1.00 7.96 O

ATOM 1510 N HIS A 208 6.171 42.636 79.372 1.00 7.16 N

ATOM 1511 CA HIS A 208 5.442 43.863 79.057 1.00 7.21 C

ATOM 1512 CB HIS A 208 6.138 44.622 77.917 1.00 7.26 C

ATOM 1513 CG HIS A 208 7.557 45.003 78.219 1.00 7.13 C

ATOM 1514 NDl HIS A 208 8.605 44.713 77.371 1.00 8.24 N

ATOM 1515 CEl HIS A 208 9.729 45.176 77.891 1.00 7.57 C

ATOM 1516 NE2 HIS A 208 9.450 45.748 79.048 1.00 7.65 N

ATOM 1517 CD2 HIS A 208 8.099 45.652 79.278 1.00 8.75 C

ATOM 1518 C HIS A 208 3.994 43.533 78.705 1.00 7.29 C

ATOM 1519 O HIS A 208 3.694 43.162 77.573 1.00 7.21 O

ATOM 1520 N VAL A 209 3.103 43.653 79.689 1.00 7.36 N

ATOM 1521 CA VAL A 209 1.733 43.182 79.522 1.00 7.60 C

ATOM 1522 CB VAL A 209 1.091 42.708 80.852 1.00 7.46 C

ATOM 1523 CGl VAL A 209 0.249 42.020 80.574 1.00 8.28 C

ATOM 1524 CG2 VAL A 209 2.028 41.759 81.617 1.00 7.88 C

ATOM 1525 C VAL A 209 0.896 44.280 78.880 1.00 7.65 C

ATOM 1526 O VAL A 209 0.779 45.387 79.413 1.00 7.50 O

ATOM 1527 N MET A 210 0.315 43.961 77.730 1.00 7.74 N

ATOM 1528 CA MET A 210 0.416 44.949 76.943 1.00 8.08 C

ATOM 1529 CB MET A 210 0.350 44.595 75.454 1.00 8.12 C

ATOM 1530 CG MET A 210 1.088 44.626 74.915 1.00 8.90 C

ATOM 1531 SD MET A 210 1.223 44.360 73.140 1.00 9.16

ATOM 1532 CE MET A 210 1.016 42.579 73.058 1.00 9.91 C

ATOM 1533 C MET A 210 1.844 45.131 77.450 1.00 8.08 C

ATOM 1534 O MET A 210 2.819 44.753 76.791 1.00 7.86 O

ATOM 1535 N THR A 211 1.939 45.749 78.623 1.00 8.38 N

ATOM 1536 CA THR A 211 3.202 45.971 79.319 1.00 8.96 C

ATOM 1537 CB THR A 211 2.995 46.123 80.839 1.00 9.08 C

ATOM 1538 OGl THR A 211 1.883 46.990 81.082 1.00 8.94 O

ATOM 1539 CG2 THR A 211 2.748 44.767 81.495 1.00 9.12 C

ATOM 1540 C THR A 211 3.904 47.206 78.760 1.00 9.34 C

ATOM 1541 O THR A 211 4.079 48.216 79.451 1.00 9.37 O

ATOM 1542 N TYR A 212 4.283 47.104 77.491 1.00 9.68 N

ATOM 1543 CA TYR A 212 5.072 48.121 76.799 1.00 9.73 C

ATOM 1544 CB TYR A 212 4.231 49.359 76.446 1.00 10.18 C

ATOM 1545 CG TYR A 212 2.825 49.063 75.967 1.00 10.09 C

ATOM 1546 CDl TYR A 212 2.608 48.414 74.752 1.00 10.24 C

ATOM 1547 CEl TYR A 212 1.321 48.143 74.303 1.00 11.19 C

ATOM 1548 CZ TYR A 212 0.235 48.515 75.077 1.00 11.02 C

ATOM 1549 OH TYR A 212 1.030 48.246 74.620 1.00 11.59 O

ATOM 1550 CE2 TYR A 212 0.416 49.164 76.289 1.00 10.79 C

ATOM 1551 CD2 TYR A 212 1.712 49.436 76.728 1.00 10.88 C

ATOM 1552 C TYR A 212 5.708 47.477 75.569 1.00 10.01 C

ATOM 1553 O TYR A 212 5.571 46.268 75.372 1.00 9.97 O

ATOM 1554 N ASP A 213 6.398 48.275 74.752 1.00 9.60 N

ATOM 1555 CA ASP A 213 7.279 47.762 73.685 1.00 9.86 C

ATOM 1556 CB ASP A 213 6.480 47.171 72.513 1.00 9.53 C

ATOM 1557 CG ASP A 213 5.430 48.126 71.978 1.00 9.86 C

ATOM 1558 ODl ASP A 213 5.745 49.321 71.759 1.00 9.38 O

ATOM 1559 OD2 ASP A 213 4.286 47.672 71.774 1.00 9.94 O

ATOM 1560 C ASP A 213 8.260 46.728 74.242 1.00 10.03 C

ATOM 1561 O ASP A 213 8.634 45.766 73.561 1.00 9.97 O

ATOM 1562 N LEU A 214 8.671 46.943 75.489 1.00 10.30 N

ATOM 1563 CA LEU A 214 9.543 45.999 76.186 1.00 10.75 C

ATOM 1564 CB LEU A 214 9.402 46.161 77.707 1.00 10.47 C

ATOM 1565 CG LEU A 214 8.015 45.795 78.273 1.00 10.92 C

ATOM 1566 CDl LEU A 214 7.927 46.053 79.772 1.00 10.78 C

ATOM 1567 CD2 LEU A 214 7.645 44.345 77.958 1.00 11.19 C W2025-7029WO / AM102903-PCT

ATOM 1568 C LEU A 214 10.999 46.111 75.724 1.00 11.29 C

ATOM 1569 O LEU A 214 11.786 45.172 75.888 1.00 11.18 O

ATOM 1570 N HIS A 215 11.338 47.264 75.148 1.00 11.50 N

ATOM 1571 CA HIS A 215 12.604 47.476 74.453 1.00 12.31 C

ATOM 1572 CB HIS A 215 13.589 48.255 75.322 1.00 12.12 C

ATOM 1573 CG HIS A 215 14.041 47.514 76.538 1.00 12.09 C

ATOM 1574 NDl HIS A 215 14.943 46.472 76.484 1.00 11.35 N

ATOM 1575 CEl HIS A 215 15.158 46.018 77.706 1.00 11.48 C

ATOM 1576 NE2 HIS A 215 14.427 46.726 78.549 1.00 11.49 N

ATOM 1577 CD2 HIS A 215 13.723 47.671 77.844 1.00 11.54 C

ATOM 1578 C HIS A 215 12.359 48.265 73.173 1.00 13.18 C

ATOM 1579 O HIS A 215 11.356 48.963 73.051 1.00 13.34 O

ATOM 1580 N GLY A 216 13.287 48.157 72.228 1.00 14.18 N

ATOM 1581 CA GLY A 216 13.200 48.900 70.973 1.00 15.33 C

ATOM 1582 C GLY A 216 14.497 48.785 70.210 1.00 16.16 C

ATOM 1583 O GLY A 216 15.401 48.052 70.624 1.00 15.81 O

ATOM 1584 N SER A 217 14.588 49.507 69.095 1.00 17.07 N

ATOM 1585 CA SER A 217 15.816 49.566 68.303 1.00 18.02 C

ATOM 1586 CB SER A 217 15.654 50.536 67.131 1.00 17.96 C

ATOM 1587 OG SER A 217 14.643 50.093 66.247 1.00 18.32 O

ATOM 1588 C SER A 217 16.306 48.198 67.812 1.00 18.57 C

ATOM 1589 O SER A 217 17.503 48.023 67.563 1.00 18.49 O

ATOM 1590 N TRP A 218 15.381 47.243 67.694 1.00 19.38 N

ATOM 1591 CA TRP A 218 15.703 45.864 67.300 1.00 20.04 C

ATOM 1592 CB TRP A 218 14.441 44.976 67.287 1.00 20.42 C

ATOM 1593 CG TRP A 218 13.675 44.907 68.596 1.00 21.72 C

ATOM 1594 CDl TRP A 218 13.917 44.065 69.648 1.00 22.52 C

ATOM 1595 NEl TRP A 218 13.009 44.291 70.659 1.00 23.42 N

ATOM 1596 CE2 TRP A 218 12.146 45.283 70.269 1.00 23.23 C

ATOM 1597 CD2 TRP A 218 12.533 45.694 68.969 1.00 22.98 C

ATOM 1598 CE3 TRP A 218 11.805 46.714 68.336 1.00 23.35 C

ATOM 1599 CZ3 TRP A 218 10.721 47.284 69.012 1.00 24.05 C

ATOM 1600 CH2 TRP A 218 10.363 46.852 70.306 1.00 23.75 C

ATOM 1601 CZ2 TRP A 218 11.061 45.857 70.948 1.00 23.41 C

ATOM 1602 C TRP A 218 16.811 45.235 68.155 1.00 20.06 C

ATOM 1603 O TRP A 218 17.518 44.335 67.698 1.00 20.43 O

ATOM 1604 N GLU A 219 16.969 45.727 69.384 1.00 19.74 N

ATOM 1605 CA GLU A 219 17.965 45.197 70.317 1.00 19.46 C

ATOM 1606 CB GLU A 219 17.512 45.421 71.767 1.00 19.56 C

ATOM 1607 CG GLU A 219 16.286 44.591 72.144 1.00 19.68 C

ATOM 1608 CD GLU A 219 15.767 44.868 73.543 1.00 20.45 C

ATOM 1609 OEl GLU A 219 15.589 46.052 73.900 1.00 19.77 O

ATOM 1610 OE2 GLU A 219 15.517 43.888 74.279 1.00 21.51 O

ATOM 1611 C GLU A 219 19.379 45.747 70.095 1.00 19.12 C

ATOM 1612 O GLU A 219 20.352 45.170 70.584 1.00 19.33 O

ATOM 1613 N GLY A 220 19.484 46.857 69.367 1.00 18.61 N

ATOM 1614 CA GLY A 220 20.781 47.482 69.079 1.00 17.92 C

ATOM 1615 C GLY A 220 21.352 48.338 70.197 1.00 17.33 C

ATOM 1616 O GLY A 220 22.501 48.779 70.126 1.00 17.21 O

ATOM 1617 N TYR A 221 20.554 48.572 71.235 1.00 16.88 N

ATOM 1618 CA TYR A 221 20.929 49.488 72.312 1.00 16.51 C

ATOM 1619 CB TYR A 221 21.706 48.773 73.423 1.00 16.99 C

ATOM 1620 CG TYR A 221 21.100 47.472 73.902 1.00 19.30 C

ATOM 1621 CDl TYR A 221 20.074 47.457 74.855 1.00 21.05 C

ATOM 1622 CEl TYR A 221 19.521 46.250 75.300 1.00 21.71 C

ATOM 1623 CZ TYR A 221 20.006 45.047 74.794 1.00 21.96 C

ATOM 1624 OH TYR A 221 19.473 43.847 75.220 1.00 22.42 O

ATOM 1625 CE2 TYR A 221 21.024 45.039 73.855 1.00 21.47 C

ATOM 1626 CD2 TYR A 221 21.569 46.248 73.416 1.00 20.71 C

ATOM 1627 C TYR A 221 19.698 50.182 72.875 1.00 15.63 C

ATOM 1628 O TYR A 221 18.570 49.711 72.672 1.00 15.59 O

ATOM 1629 N THR A 222 19.911 51.299 73.572 1.00 14.47 N

ATOM 1630 CA THR A 222 18.802 52.055 74.146 1.00 13.76 C W2025-7029WO / AM102903-PCT

ATOM 1631 CB THR A 222 19.217 53.441 74.687 1.00 13.78 C

ATOM 1632 OGl THR A 222 20.170 53.280 75.742 1.00 13.96 O

ATOM 1633 CG2 THR A 222 19.799 54.315 73.590 1.00 14.69 C

ATOM 1634 C THR A 222 18.161 51.268 75.279 1.00 12.87 C

ATOM 1635 O THR A 222 18.845 50.602 76.061 1.00 12.48 O

ATOM 1636 N GLY A 223 16.839 51.339 75.342 1.00 12.33 N

ATOM 1637 CA GLY A 223 16.075 50.698 76.403 1.00 11.41 C

ATOM 1638 C GLY A 223 14.721 51.363 76.539 1.00 10.94 C

ATOM 1639 O GLY A 223 14.252 52.037 75.614 1.00 10.83 O

ATOM 1640 N GLU A 224 14.087 51.162 77.691 1.00 10.25 N

ATOM 1641 CA GLU A 224 12.822 51.822 77.989 1.00 9.62 C

ATOM 1642 CB GLU A 224 12.689 52.050 79.493 1.00 9.70 C

ATOM 1643 CG GLU A 224 13.549 53.207 80.007 1.00 10.23 C

ATOM 1644 CD GLU A 224 12.985 54.587 79.666 1.00 9.94 C

ATOM 1645 OEl GLU A 224 11.957 54.683 78.954 1.00 9.63 O

ATOM 1646 OE2 GLU A 224 13.578 55.589 80.125 1.00 9.58 O

ATOM 1647 C GLU A 224 11.603 51.082 77.441 1.00 9.19 C

ATOM 1648 O GLU A 224 11.599 49.858 77.357 1.00 8.59 O

ATOM 1649 N ASN A 225 10.577 51.853 77.081 1.00 9.06 N

ATOM 1650 CA ASN A 225 -9.339 51.332 76.510 1.00 8.67 C

ATOM 1651 CB ASN A 225 -8.455 52.497 76.052 1.00 8.43 C

ATOM 1652 CG ASN A 225 -7.280 52.048 75.201 1.00 8.02 C

ATOM 1653 ODl ASN A 225 -7.305 50.977 74.586 1.00 8.72 O

ATOM 1654 ND2 ASN A 225 -6.244 52.877 75.157 1.00 7.76 N

ATOM 1655 C ASN A 225 -8.563 50.484 77.502 1.00 8.78 C

ATOM 1656 O ASN A 225 -8.122 49.383 77.178 1.00 8.85 O

ATOM 1657 N SER A 226 -8.401 51.027 78.704 1.00 8.70 N

ATOM 1658 CA SER A 226 -7.570 50.434 79.740 1.00 9.21 C

ATOM 1659 CB SER A 226 -6.158 51.026 79.664 1.00 9.48 C

ATOM 1660 OG SER A 226 -5.267 50.392 80.565 1.00 10.83 O

ATOM 1661 C SER A 226 -8.203 50.673 81.118 1.00 8.93 C

ATOM 1662 O SER A 226 -7.606 51.317 81.983 1.00 8.93 O

ATOM 1663 N PRO A 227 -9.423 50.147 81.336 1.00 8.88 N

ATOM 1664 CA PRO A 227 10.034 50.353 82.650 1.00 8.60 C

ATOM 1665 CB PRO A 227 11.419 49.736 82.488 1.00 8.89 C

ATOM 1666 CG PRO A 227 11.273 48.739 81.391 1.00 8.48 C

ATOM 1667 CD PRO A 227 10.285 49.352 80.444 1.00 8.92 C

ATOM 1668 C PRO A 227 -9.265 49.611 83.733 1.00 8.44 C

ATOM 1669 O PRO A 227 -8.785 48.501 83.494 1.00 8.36 O

ATOM 1670 N LEU A 228 -9.151 50.213 84.912 1.00 8.45 N

ATOM 1671 CA LEU A 228 -8.423 49.564 86.005 1.00 8.72 C

ATOM 1672 CB LEU A 228 -8.060 50.575 87.097 1.00 8.54 C

ATOM 1673 CG LEU A 228 -7.289 50.071 88.324 1.00 8.43 C

ATOM 1674 CDl LEU A 228 -6.058 49.263 87.930 1.00 8.38 C

ATOM 1675 CD2 LEU A 228 -6.905 51.252 89.219 1.00 8.71 C

ATOM 1676 C LEU A 228 -9.222 48.400 86.581 1.00 9.29 C

ATOM 1677 O LEU A 228 -8.677 47.323 86.833 1.00 9.14 O

ATOM 1678 N TYR A 229 10.513 48.632 86.790 1.00 9.92 N

ATOM 1679 CA TYR A 229 11.392 47.627 87.368 1.00 10.68 C

ATOM 1680 CB TYR A 229 11.946 48.117 88.709 1.00 10.92 C

ATOM 1681 CG TYR A 229 10.878 48.468 89.723 1.00 11.17 C

ATOM 1682 CDl TYR A 229 -9.982 47.501 90.182 1.00 11.61 C

ATOM 1683 CEl TYR A 229 -8.996 47.818 91.116 1.00 12.50 C

ATOM 1684 CZ TYR A 229 -8.903 49.118 91.598 1.00 12.24 C

ATOM 1685 OH TYR A 229 -7.936 49.438 92.525 1.00 13.51 O

ATOM 1686 CE2 TYR A 229 -9.780 50.094 91.159 1.00 12.26 C

ATOM 1687 CD2 TYR A 229 10.764 49.765 90.221 1.00 11.64 C

ATOM 1688 C TYR A 229 12.534 47.323 86.418 1.00 11.33 C

ATOM 1689 O TYR A 229 12.713 48.015 85.414 1.00 11.41 O

ATOM 1690 N LYS A 230 13.309 46.290 86.734 1.00 12.18 N

ATOM 1691 CA LYS A 230 14.479 45.988 85.928 1.00 13.05 C

ATOM 1692 CB LYS A 230 14.970 44.558 86.173 1.00 13.60 C

ATOM 1693 CG LYS A 230 15.510 44.277 87.554 1.00 15.18 C W2025-7029WO / AM102903-PCT

ATOM 1694 CD LYS A 230 15.980 42.826 87.618 1.00 18.10 C

ATOM 1695 CE LYS A 230 16.262 42.405 89.037 1.00 20.81 C

ATOM 1696 NZ LYS A 230 16.756 41.003 89.066 1.00 22.66 N

ATOM 1697 C LYS A 230 15.598 47.013 86.140 1.00 12.93 C

ATOM 1698 O LYS A 230 15.686 47.664 87.191 1.00 13.06 O

ATOM 1699 N TYR A 231 16.427 47.167 85.114 1.00 12.86 N

ATOM 1700 CA TYR A 231 17.651 47.947 85.206 1.00 12.89 C

ATOM 1701 CB TYR A 231 18.032 48.472 83.817 1.00 12.91 C

ATOM 1702 CG TYR A 231 19.037 49.603 83.853 1.00 13.41 C

ATOM 1703 CDl TYR A 231 18.654 50.886 84.256 1.00 14.43 C

ATOM 1704 CEl TYR A 231 19.576 51.932 84.301 1.00 15.65 C

ATOM 1705 CZ TYR A 231 20.892 51.697 83.938 1.00 15.36 C

ATOM 1706 OH TYR A 231 21.795 52.736 83.978 1.00 16.92 O

ATOM 1707 CE2 TYR A 231 21.301 50.436 83.536 1.00 14.70 C

ATOM 1708 CD2 TYR A 231 20.369 49.393 83.493 1.00 14.34 C

ATOM 1709 C TYR A 231 18.734 47.005 85.733 1.00 12.58 C

ATOM 1710 O TYR A 231 18.682 45.817 85.440 1.00 12.17 O

ATOM 1711 N PRO A 232 19.705 47.519 86.526 1.00 12.73 N

ATOM 1712 CA PRO A 232 20.747 46.645 87.079 1.00 12.90 C

ATOM 1713 CB PRO A 232 21.801 47.632 87.590 1.00 13.19 C

ATOM 1714 CG PRO A 232 21.042 48.842 87.935 1.00 13.30 C

ATOM 1715 CD PRO A 232 19.869 48.912 86.983 1.00 12.82 C

ATOM 1716 C PRO A 232 21.380 45.687 86.071 1.00 12.81 C

ATOM 1717 O PRO A 232 21.707 44.557 86.428 1.00 12.82 O

ATOM 1718 N THR A 233 21.540 46.122 84.825 1.00 12.94 N

ATOM 1719 CA THR A 233 22.223 45.306 83.813 1.00 13.44 C

ATOM 1720 CB THR A 233 22.901 46.191 82.740 1.00 13.42 C

ATOM 1721 OGl THR A 233 21.915 47.001 82.089 1.00 14.33 O

ATOM 1722 CG2 THR A 233 23.965 47.080 83.379 1.00 13.86 C

ATOM 1723 C THR A 233 21.333 44.248 83.137 1.00 13.52 C

ATOM 1724 O THR A 233 21.824 43.447 82.321 1.00 13.69 O

ATOM 1725 N ASP A 234 20.039 44.250 83.472 1.00 13.83 N

ATOM 1726 CA ASP A 234 19.085 43.260 82.950 1.00 14.01 C

ATOM 1727 CB ASP A 234 17.632 43.675 83.238 1.00 13.88 C

ATOM 1728 CG ASP A 234 17.191 44.909 82.460 1.00 13.87 C

ATOM 1729 ODl ASP A 234 16.134 45.465 82.821 1.00 12.92 O

ATOM 1730 OD2 ASP A 234 17.877 45.326 81.501 1.00 14.42 O

ATOM 1731 C ASP A 234 19.340 41.869 83.537 1.00 14.43 C

ATOM 1732 O ASP A 234 18.852 41.544 84.621 1.00 15.44 O

ATOM 1733 N THR A 235 20.104 41.053 82.814 1.00 14.46 N

ATOM 1734 CA THR A 235 20.446 39.701 83.261 1.00 14.54 C

ATOM 1735 CB THR A 235 21.951 39.416 83.084 1.00 14.68 C

ATOM 1736 OGl THR A 235 22.319 39.652 81.721 1.00 15.00 O

ATOM 1737 CG2 THR A 235 22.792 40.318 83.986 1.00 14.78 C

ATOM 1738 C THR A 235 19.649 38.649 82.488 1.00 14.47 C

ATOM 1739 O THR A 235 19.165 38.919 81.385 1.00 14.31 O

ATOM 1740 N GLY A 236 19.520 37.455 83.068 1.00 14.57 N

ATOM 1741 CA GLY A 236 18.827 36.339 82.420 1.00 14.57 C

ATOM 1742 C GLY A 236 17.406 36.699 82.028 1.00 14.65 C

ATOM 1743 O GLY A 236 16.678 37.301 82.818 1.00 14.39 O

ATOM 1744 N SER A 237 17.028 36.361 80.797 1.00 14.90 N

ATOM 1745 CA SER A 237 15.682 36.647 80.283 1.00 15.15 C

ATOM 1746 CB SER A 237 15.431 35.925 78.951 1.00 15.24 C

ATOM 1747 OG SER A 237 16.249 36.434 77.911 1.00 17.41 O

ATOM 1748 C SER A 237 15.380 38.143 80.155 1.00 14.95 C

ATOM 1749 O SER A 237 14.213 38.540 80.115 1.00 14.69 O

ATOM 1750 N ASN A 238 16.425 38.970 80.111 1.00 14.69 N

ATOM 1751 CA ASN A 238 16.239 40.422 80.110 1.00 14.71 C

ATOM 1752 CB ASN A 238 17.550 41.150 79.802 1.00 15.19 C

ATOM 1753 CG ASN A 238 17.946 41.035 78.339 1.00 17.13 C

ATOM 1754 ODl ASN A 238 17.090 40.897 77.461 1.00 19.20 O

ATOM 1755 ND2 ASN A 238 19.247 41.089 78.070 1.00 19.44 N

ATOM 1756 C ASN A 238 15.596 40.951 81.389 1.00 14.09 C W2025-7029WO / AM102903-PCT

ATOM 1757 O ASN A 238 14.954 41.999 81.371 1.00 13.86 O

ATOM 1758 N ALA A 239 15.758 40.211 82.488 1.00 13.66 N

ATOM 1759 CA ALA A 239 15.148 40.574 83.777 1.00 13.48 C

ATOM 1760 CB ALA A 239 15.725 39.719 84.910 1.00 13.68 C

ATOM 1761 C ALA A 239 13.619 40.488 83.779 1.00 13.09 C

ATOM 1762 O ALA A 239 12.979 40.892 84.756 1.00 13.01 O

ATOM 1763 N TYR A 240 13.045 39.963 82.696 1.00 12.76 N

ATOM 1764 CA TYR A 240 11.590 39.837 82.568 1.00 12.87 C

ATOM 1765 CB TYR A 240 11.206 38.599 81.752 1.00 13.46 C

ATOM 1766 CG TYR A 240 11.858 37.295 82.175 1.00 15.32 C

ATOM 1767 CDl TYR A 240 12.178 37.043 83.510 1.00 16.59 C

ATOM 1768 CEl TYR A 240 12.768 35.839 83.896 1.00 17.63 C

ATOM 1769 CZ TYR A 240 13.026 34.875 82.939 1.00 18.53 C

ATOM 1770 OH TYR A 240 13.604 33.681 83.310 1.00 20.30 O

ATOM 1771 CE2 TYR A 240 12.704 35.095 81.611 1.00 18.39 C

ATOM 1772 CD2 TYR A 240 12.124 36.300 81.236 1.00 17.53 C

ATOM 1773 C TYR A 240 10.972 41.067 81.905 1.00 12.09 C

ATOM 1774 O TYR A 240 -9.745 41.220 81.891 1.00 12.02 O

ATOM 1775 N LEU A 241 11.824 41.940 81.368 1.00 11.20 N

ATOM 1776 CA LEU A 241 11.378 43.054 80.528 1.00 10.55 C

ATOM 1777 CB LEU A 241 12.419 43.362 79.441 1.00 10.68 C

ATOM 1778 CG LEU A 241 12.686 42.260 78.403 1.00 10.58 C

ATOM 1779 CDl LEU A 241 13.864 42.627 77.501 1.00 10.70 C

ATOM 1780 CD2 LEU A 241 11.433 41.937 77.567 1.00 10.70 C

ATOM 1781 C LEU A 241 11.022 44.301 81.334 1.00 10.16 C

ATOM 1782 O LEU A 241 11.613 45.377 81.163 1.00 9.71 O

ATOM 1783 N ASN A 242 10.049 44.140 82.225 1.00 9.99 N

ATOM 1784 CA ASN A 242 -9.533 45.248 83.019 1.00 10.48 C

ATOM 1785 CB ASN A 242 10.446 45.558 84.218 1.00 10.24 C

ATOM 1786 CG ASN A 242 10.590 44.385 85.171 1.00 11.24 C

ATOM 1787 ODl ASN A 242 -9.771 44.203 86.068 1.00 11.84 O

ATOM 1788 ND2 ASN A 242 11.642 43.590 84.987 1.00 11.80 N

ATOM 1789 C ASN A 242 -8.102 44.968 83.463 1.00 10.14 C

ATOM 1790 O ASN A 242 -7.674 43.815 83.522 1.00 10.40 O

ATOM 1791 N VAL A 243 -7.375 46.037 83.766 1.00 10.39 N

ATOM 1792 CA VAL A 243 -5.957 45.962 84.125 1.00 10.45 C

ATOM 1793 CB VAL A 243 -5.385 47.379 84.349 1.00 10.30 C

ATOM 1794 CGl VAL A 243 -3.945 47.322 84.851 1.00 11.16 C

ATOM 1795 CG2 VAL A 243 -5.478 48.185 83.054 1.00 9.90 C

ATOM 1796 C VAL A 243 -5.725 45.079 85.351 1.00 10.76 C

ATOM 1797 O VAL A 243 -4.820 44.240 85.358 1.00 10.19 O

ATOM 1798 N ASP A 244 -6.558 45.262 86.372 1.00 11.27 N

ATOM 1799 CA ASP A 244 -6.429 44.513 87.620 1.00 11.94 C

ATOM 1800 CB ASP A 244 -7.444 45.001 88.654 1.00 12.42 C

ATOM 1801 CG ASP A 244 -7.314 44.276 89.979 1.00 14.33 C

ATOM 1802 ODl ASP A 244 -6.466 44.673 90.807 1.00 17.27 O

ATOM 1803 OD2 ASP A 244 -8.057 43.302 90.181 1.00 16.94 O

ATOM 1804 C ASP A 244 -6.538 43.004 87.419 1.00 11.75 C

ATOM 1805 O ASP A 244 -5.695 42.257 87.920 1.00 11.98 O

ATOM 1806 N TYR A 245 -7.560 42.553 86.690 1.00 11.65 N

ATOM 1807 CA TYR A 245 -7.720 41.123 86.441 1.00 11.57 C

ATOM 1808 CB TYR A 245 -9.046 40.793 85.733 1.00 12.03 C

ATOM 1809 CG TYR A 245 -9.279 39.299 85.666 1.00 13.08 C

ATOM 1810 CDl TYR A 245 10.010 38.646 86.658 1.00 14.83 C

ATOM 1811 CEl TYR A 245 10.202 37.265 86.621 1.00 15.14 C

ATOM 1812 CZ TYR A 245 -9.649 36.526 85.590 1.00 15.44 C

ATOM 1813 OH TYR A 245 -9.834 35.161 85.554 1.00 16.56 O

ATOM 1814 CE2 TYR A 245 -8.902 37.150 84.594 1.00 15.13 C

ATOM 1815 CD2 TYR A 245 -8.720 38.528 84.639 1.00 13.99 C

ATOM 1816 C TYR A 245 -6.537 40.560 85.649 1.00 11.13 C

ATOM 1817 O TYR A 245 -5.975 39.518 86.011 1.00 11.03 O

ATOM 1818 N VAL A 246 -6.160 41.263 84.584 1.00 10.37 N

ATOM 1819 CA VAL A 246 -5.115 40.786 83.673 1.00 9.95 C W2025-7029WO / AM102903-PCT

ATOM 1820 CB VAL A 246 4.995 41.677 82.416 1.00 10.13 C

ATOM 1821 CGl VAL A 246 3.808 41.240 81.572 1.00 9.43 C

ATOM 1822 CG2 VAL A 246 6.282 41.624 81.591 1.00 8.88 C

ATOM 1823 C VAL A 246 3.752 40.664 84.370 1.00 9.77 C

ATOM 1824 O VAL A 246 3.079 39.639 84.254 1.00 9.73 O

ATOM 1825 N MET A 247 3.349 41.705 85.093 1.00 9.90 N

ATOM 1826 CA MET A 247 2.072 41.666 85.802 1.00 10.10 C

ATOM 1827 CB MET A 247 1.748 43.012 86.456 1.00 9.90 C

ATOM 1828 CG MET A 247 1.507 44.150 85.466 1.00 10.07 C

ATOM 1829 SD MET A 247 0.348 43.767 84.119 1.00 9.78 S

ATOM 1830 CE MET A 247 1.149 43.323 85.019 1.00 10.08 C

ATOM 1831 C MET A 247 2.048 40.539 86.823 1.00 10.24 C

ATOM 1832 O MET A 247 1.074 39.776 86.893 1.00 10.06 O

ATOM 1833 N ASN A 248 3.134 40.413 87.584 1.00 10.62 N

ATOM 1834 CA ASN A 248 3.252 39.335 88.563 1.00 11.23 C

ATOM 1835 CB ASN A 248 4.429 39.573 89.511 1.00 11.46 C

ATOM 1836 CG ASN A 248 4.088 40.550 90.605 1.00 12.88 C

ATOM 1837 ODl ASN A 248 3.219 40.287 91.436 1.00 15.11 O

ATOM 1838 ND2 ASN A 248 4.759 41.696 90.608 1.00 14.72 N

ATOM 1839 C ASN A 248 3.323 37.943 87.952 1.00 11.09 C

ATOM 1840 O ASN A 248 2.846 36.992 88.558 1.00 11.26 O

ATOM 1841 N TYR A 249 3.900 37.827 86.756 1.00 11.04 N

ATOM 1842 CA TYR A 249 3.909 36.556 86.046 1.00 10.93 C

ATOM 1843 CB TYR A 249 4.730 36.614 84.751 1.00 11.22 C

ATOM 1844 CG TYR A 249 4.869 35.256 84.086 1.00 11.76 C

ATOM 1845 CDl TYR A 249 5.947 34.416 84.385 1.00 12.15 C

ATOM 1846 CEl TYR A 249 6.067 33.163 83.789 1.00 12.89 C

ATOM 1847 CZ TYR A 249 5.099 32.730 82.899 1.00 13.41 C

ATOM 1848 OH TYR A 249 5.212 31.492 82.312 1.00 14.07 O

ATOM 1849 CE2 TYR A 249 4.017 33.540 82.588 1.00 12.95 C

ATOM 1850 CD2 TYR A 249 3.903 34.792 83.186 1.00 12.26 C

ATOM 1851 C TYR A 249 2.481 36.113 85.757 1.00 10.66 C

ATOM 1852 O TYR A 249 2.111 34.985 86.061 1.00 10.49 O

ATOM 1853 N TRP A 250 1.684 37.006 85.169 1.00 10.28 N

ATOM 1854 CA TRP A 250 0.278 36.709 84.894 1.00 10.50 C

ATOM 1855 CB TRP A 250 0.399 37.889 84.187 1.00 10.16 C

ATOM 1856 CG TRP A 250 0.202 37.865 82.703 1.00 10.00 C

ATOM 1857 CDl TRP A 250 0.793 38.479 81.990 1.00 10.46 C

ATOM 1858 NEl TRP A 250 0.636 38.226 80.645 1.00 9.83 N

ATOM 1859 CE2 TRP A 250 0.468 37.433 80.466 1.00 9.05 C

ATOM 1860 CD2 TRP A 250 1.021 37.182 81.742 1.00 9.82 C

ATOM 1861 CE3 TRP A 250 2.178 36.393 81.836 1.00 9.64 C

ATOM 1862 CZ3 TRP A 250 2.736 35.879 80.666 1.00 8.68 C

ATOM 1863 CH2 TRP A 250 2.150 36.132 79.410 1.00 8.95 C

ATOM 1864 CZ2 TRP A 250 1.017 36.899 79.291 1.00 8.98 C

ATOM 1865 C TRP A 250 0.474 36.312 86.170 1.00 10.68 C

ATOM 1866 O TRP A 250 1.197 35.308 86.182 1.00 10.79 O

ATOM 1867 N LYS A 251 0.277 37.085 87.238 1.00 11.27 N

ATOM 1868 CA LYS A 251 0.908 36.822 88.536 1.00 12.36 C

ATOM 1869 CB LYS A 251 0.587 37.940 89.542 1.00 12.53 C

ATOM 1870 CG LYS A 251 1.302 37.783 90.882 1.00 13.71 C

ATOM 1871 CD LYS A 251 1.068 38.966 91.811 1.00 15.95 C

ATOM 1872 CE LYS A 251 1.855 38.782 93.112 1.00 19.40 C

ATOM 1873 NZ LYS A 251 1.881 40.008 93.965 1.00 23.13 N

ATOM 1874 C LYS A 251 0.506 35.454 89.103 1.00 12.55 C

ATOM 1875 O LYS A 251 1.369 34.626 89.412 1.00 12.46 O

ATOM 1876 N ASP A 252 0.801 35.220 89.212 1.00 12.72 N

ATOM 1877 CA ASP A 252 1.347 33.992 89.812 1.00 12.90 C

ATOM 1878 CB ASP A 252 2.870 34.097 89.961 1.00 13.14 C

ATOM 1879 CG ASP A 252 3.295 35.131 90.991 1.00 13.73 C

ATOM 1880 ODl ASP A 252 2.445 35.605 91.774 1.00 14.76 O

ATOM 1881 OD2 ASP A 252 4.496 35.474 91.017 1.00 16.03 O

ATOM 1882 C ASP A 252 0.998 32.729 89.028 1.00 12.95 C W2025-7029WO / AM102903-PCT

ATOM 1883 O ASP A 252 -1.011 31.625 89.580 1.00 13.10 O

ATOM 1884 N ASN A 253 -0.700 32.890 87.742 1.00 12.62 N

ATOM 1885 CA ASN A 253 -0.359 31.754 86.899 1.00 12.71 C

ATOM 1886 CB ASN A 253 -1.193 31.766 85.620 1.00 12.45 C

ATOM 1887 CG ASN A 253 -2.654 31.469 85.893 1.00 13.68 C

ATOM 1888 ODl ASN A 253 -3.066 30.302 85.946 1.00 14.87 O

ATOM 1889 ND2 ASN A 253 -3.446 32.522 86.091 1.00 12.92 N

ATOM 1890 C ASN A 253 1.139 31.578 86.626 1.00 12.53 C

ATOM 1891 O ASN A 253 1.532 30.851 85.712 1.00 12.75 O

ATOM 1892 N GLY A 254 1.966 32.237 87.435 1.00 12.37 N

ATOM 1893 CA GLY A 254 3.380 31.881 87.506 1.00 12.34 C

ATOM 1894 C GLY A 254 4.410 32.958 87.232 1.00 12.08 C

ATOM 1895 O GLY A 254 5.605 32.718 87.419 1.00 12.68 O

ATOM 1896 N ALA A 255 3.972 34.135 86.791 1.00 11.66 N

ATOM 1897 CA ALA A 255 4.904 35.237 86.540 1.00 11.20 C

ATOM 1898 CB ALA A 255 4.387 36.152 85.435 1.00 11.18 C

ATOM 1899 C ALA A 255 5.175 36.033 87.813 1.00 11.33 C

ATOM 1900 O ALA A 255 4.230 36.493 88.475 1.00 11.40 O

ATOM 1901 N PRO A 256 6.466 36.211 88.161 1.00 10.96 N

ATOM 1902 CA PRO A 256 6.804 36.979 89.358 1.00 10.69 C

ATOM 1903 CB PRO A 256 8.336 36.868 89.442 1.00 10.82 C

ATOM 1904 CG PRO A 256 8.710 35.755 88.546 1.00 11.69 C

ATOM 1905 CD PRO A 256 7.671 35.717 87.470 1.00 11.05 C

ATOM 1906 C PRO A 256 6.382 38.434 89.184 1.00 10.19 C

ATOM 1907 O PRO A 256 6.616 39.024 88.126 1.00 9.68 O

ATOM 1908 N ALA A 257 5.745 38.995 90.210 1.00 9.85 N

ATOM 1909 CA ALA A 257 5.249 40.369 90.153 1.00 9.69 C

ATOM 1910 CB ALA A 257 4.637 40.777 91.493 1.00 9.97 C

ATOM 1911 C ALA A 257 6.348 41.350 89.742 1.00 9.64 C

ATOM 1912 O ALA A 257 6.099 42.273 88.966 1.00 9.18 O

ATOM 1913 N GLU A 258 7.563 41.119 90.244 1.00 9.97 N

ATOM 1914 CA GLU A 258 8.707 42.003 89.995 1.00 10.10 C

ATOM 1915 CB GLU A 258 9.881 41.660 90.931 1.00 10.59 C

ATOM 1916 CG GLU A 258 10.468 40.254 90.743 1.00 11.64 C

ATOM 1917 CD GLU A 258 9.857 39.202 91.666 1.00 13.04 C

ATOM 1918 OEl GLU A 258 8.664 39.305 92.022 1.00 13.80 O

ATOM 1919 OE2 GLU A 258 10.587 38.257 92.036 1.00 15.43 O

ATOM 1920 C GLU A 258 9.169 42.047 88.527 1.00 10.20 C

ATOM 1921 O GLU A 258 9.831 43.005 88.115 1.00 9.99 O

ATOM 1922 N LYS A 259 8.823 41.022 87.744 1.00 10.01 N

ATOM 1923 CA LYS A 259 9.146 41.020 86.310 1.00 10.27 C

ATOM 1924 CB LYS A 259 9.530 39.622 85.824 1.00 10.41 C

ATOM 1925 CG LYS A 259 10.888 39.128 86.308 1.00 11.74 C

ATOM 1926 CD LYS A 259 11.264 37.862 85.568 1.00 12.66 C

ATOM 1927 CE LYS A 259 12.677 37.423 85.912 1.00 12.99 C

ATOM 1928 NZ LYS A 259 13.057 36.178 85.195 1.00 14.25 N

ATOM 1929 C LYS A 259 7.988 41.540 85.469 1.00 9.91 C

ATOM 1930 O LYS A 259 8.155 41.815 84.273 1.00 10.17 O

ATOM 1931 N LEU A 260 6.817 41.662 86.091 1.00 9.41 N

ATOM 1932 CA LEU A 260 5.618 42.110 85.387 1.00 8.93 C

ATOM 1933 CB LEU A 260 4.354 41.593 86.084 1.00 9.14 C

ATOM 1934 CG LEU A 260 4.056 40.108 85.867 1.00 9.06 C

ATOM 1935 CDl LEU A 260 2.971 39.623 86.818 1.00 10.17 C

ATOM 1936 CD2 LEU A 260 3.664 39.855 84.416 1.00 9.79 C

ATOM 1937 C LEU A 260 5.571 43.627 85.250 1.00 8.98 C

ATOM 1938 O LEU A 260 5.713 44.352 86.234 1.00 8.53 O

ATOM 1939 N ILE A 261 5.370 44.087 84.016 1.00 8.26 N

ATOM 1940 CA ILE A 261 5.342 45.510 83.701 1.00 8.50 C

ATOM 1941 CB ILE A 261 6.468 45.897 82.696 1.00 8.14 C

ATOM 1942 CGl ILE A 261 7.861 45.482 83.220 1.00 9.48 C

ATOM 1943 CDl ILE A 261 8.329 46.179 84.503 1.00 10.40 C

ATOM 1944 CG2 ILE A 261 6.400 47.385 82.348 1.00 8.98 C

ATOM 1945 C ILE A 261 3.965 45.868 83.149 1.00 8.37 C W2025-7029WO / AM102903-PCT

ATOM 1946 O ILE A 261 3.508 45.290 82.156 1.00 9.02 O

ATOM 1947 N VAL A 262 3.302 46.808 83.818 1.00 8.38 N

ATOM 1948 CA VAL A 262 1.924 47.180 83.488 1.00 8.23 C

ATOM 1949 CB VAL A 262 1.236 47.873 84.688 1.00 8.25 C

ATOM 1950 CGl VAL A 262 -0.220 48.206 84.362 1.00 8.40 C

ATOM 1951 CG2 VAL A 262 1.320 46.984 85.940 1.00 8.27 C

ATOM 1952 C VAL A 262 1.867 48.084 82.251 1.00 7.89 C

ATOM 1953 O VAL A 262 2.633 49.037 82.145 1.00 7.47 O

ATOM 1954 N GLY A 263 0.958 47.776 81.323 1.00 7.87 N

ATOM 1955 CA GLY A 263 0.794 48.578 80.105 1.00 8.05 C

ATOM 1956 C GLY A 263 -0.061 49.825 80.282 1.00 8.49 C

ATOM 1957 O GLY A 263 -1.199 49.748 80.763 1.00 8.35 O

ATOM 1958 N PHE A 264 0.499 50.967 79.879 1.00 8.37 N

ATOM 1959 CA PHE A 264 -0.172 52.269 79.937 1.00 8.49 C

ATOM 1960 CB PHE A 264 0.608 53.242 80.835 1.00 8.37 C

ATOM 1961 CG PHE A 264 0.457 52.980 82.309 1.00 9.17 C

ATOM 1962 CDl PHE A 264 1.078 51.886 82.908 1.00 9.66 C

ATOM 1963 CEl PHE A 264 0.949 51.653 84.278 1.00 9.63 C

ATOM 1964 CZ PHE A 264 0.198 52.529 85.060 1.00 9.50 C

ATOM 1965 CE2 PHE A 264 -0.420 53.624 84.475 1.00 9.09 C

ATOM 1966 CD2 PHE A 264 -0.285 53.847 83.104 1.00 9.04 C

ATOM 1967 C PHE A 264 -0.278 52.872 78.534 1.00 8.60 C

ATOM 1968 O PHE A 264 0.740 53.075 77.874 1.00 8.75 O

ATOM 1969 N PRO A 265 -1.509 53.152 78.069 1.00 8.36 N

ATOM 1970 CA PRO A 265 -1.726 53.776 76.770 1.00 8.16 C

ATOM 1971 CB PRO A 265 -3.066 53.182 76.342 1.00 7.89 C

ATOM 1972 CG PRO A 265 -3.811 53.010 77.639 1.00 8.46 C

ATOM 1973 CD PRO A 265 -2.786 52.816 78.731 1.00 8.24 C

ATOM 1974 C PRO A 265 -1.827 55.299 76.819 1.00 8.09 C

ATOM 1975 O PRO A 265 -2.579 55.850 77.630 1.00 7.97 O

ATOM 1976 N THR A 266 -1.068 55.970 75.951 1.00 7.91 N

ATOM 1977 CA THR A 266 -1.187 57.418 75.777 1.00 7.74 C

ATOM 1978 CB THR A 266 0.193 58.091 75.643 1.00 8.09 C

ATOM 1979 OGl THR A 266 0.931 57.440 74.602 1.00 7.85 O

ATOM 1980 CG2 THR A 266 0.961 57.985 76.947 1.00 7.95 C

ATOM 1981 C THR A 266 -2.061 57.726 74.556 1.00 7.86 C

ATOM 1982 O THR A 266 -1.825 58.695 73.824 1.00 7.38 O

ATOM 1983 N TYR A 267 -3.068 56.881 74.355 1.00 7.70 N

ATOM 1984 CA TYR A 267 -4.047 57.045 73.286 1.00 7.90 C

ATOM 1985 CB TYR A 267 -3.594 56.322 72.008 1.00 7.76 C

ATOM 1986 CG TYR A 267 -3.596 54.807 72.138 1.00 8.01 C

ATOM 1987 CDl TYR A 267 -4.720 54.052 71.782 1.00 7.91 C

ATOM 1988 CEl TYR A 267 -4.722 52.656 71.914 1.00 7.70 C

ATOM 1989 CZ TYR A 267 -3.589 52.028 72.411 1.00 8.06 C

ATOM 1990 OH TYR A 267 -3.565 50.669 72.544 1.00 9.00 O

ATOM 1991 CE2 TYR A 267 -2.469 52.761 72.767 1.00 7.70 C

ATOM 1992 CD2 TYR A 267 -2.476 54.134 72.627 1.00 8.27 C

ATOM 1993 C TYR A 267 -5.379 56.470 73.745 1.00 8.28 C

ATOM 1994 O TYR A 267 -5.429 55.699 74.706 1.00 8.45 O

ATOM 1995 N GLY A 268 -6.451 56.836 73.049 1.00 8.71 N

ATOM 1996 CA GLY A 268 -7.769 56.286 73.339 1.00 9.23 C

ATOM 1997 C GLY A 268 -8.424 55.672 72.122 1.00 9.54 C

ATOM 1998 O GLY A 268 -7.968 55.869 70.988 1.00 9.72 O

ATOM 1999 N HIS A 269 -9.487 54.909 72.361 1.00 9.83 N

ATOM 2000 CA HIS A 269 10.317 54.382 71.279 1.00 10.22 C

ATOM 2001 CB HIS A 269 10.736 52.946 71.567 1.00 10.73 C

ATOM 2002 CG HIS A 269 -9.687 51.928 71.258 1.00 11.20 C

ATOM 2003 NDl HIS A 269 -9.591 51.304 70.032 1.00 12.88 N

ATOM 2004 CEl HIS A 269 -8.589 50.442 70.058 1.00 13.71 C

ATOM 2005 NE2 HIS A 269 -8.034 50.486 71.255 1.00 11.46 N

ATOM 2006 CD2 HIS A 269 -8.707 51.401 72.026 1.00 12.15 C

ATOM 2007 C HIS A 269 11.577 55.220 71.165 1.00 10.49 C

ATOM 2008 O HIS A 269 12.238 55.489 72.172 1.00 9.84 O W2025-7029WO / AM102903-PCT

ATOM 2009 N ASN A 270 -11.927 55 .619 69.946 .00 10.83 N

ATOM 2010 CA ASN A 270 -13.170 56.362 69.751 .00 11.13 C

ATOM 2011 CB ASN A 270 -12.923 57.783 69.197 .00 11.23 C

ATOM 2012 CG ASN A 270 -12.332 57.784 67.805 .00 10.93 C

ATOM 2013 ODl ASN A 270 -12.196 56.740 67.176 .00 10.63 O

ATOM 2014 ND2 ASN A 270 -11.990 58.967 67.311 .00 10.62 N

ATOM 2015 C ASN A 270 -14.233 55.583 68.969 .00 11.77 C

ATOM 2016 O ASN A 270 -13.942 54.560 68.333 .00 11.56 O

ATOM 2017 N PHE A 271 -15.466 56.071 69.058 .00 12.54 N

ATOM 2018 CA PHE A 271 -16.644 55.360 68.593 .00 13.27 C

ATOM 2019 CB PHE A 271 -17.390 54.743 69.786 .00 13.22 C

ATOM 2020 CG PHE A 271 -16.602 53.717 70.565 .00 12.76 C

ATOM 2021 CDl PHE A 271 -15.622 54.105 71.482 .00 12.48 C

ATOM 2022 CEl PHE A 271 -14.913 53.159 72.213 1.00 12.18 C

ATOM 2023 C Z PHE A 271 -15.192 51.817 72.052 1.00 12.52 C

ATOM 2024 CE2 PHE A 271 -16.187 51.416 71.160 1.00 13.23 C

ATOM 2025 CD2 PHE A 271 -16.883 52.366 70.425 1.00 13.66 C

ATOM 2026 C PHE A 271 -17.598 56.350 67.939 1.00 14.37 C

ATOM 2027 O PHE A 271 -17.576 57.545 68.253 1.00 14.52 O

ATOM 2028 N ILE A 272 -18.451 55.843 67.051 1.00 15.40 N

ATOM 2029 CA ILE A 272 -19.626 56.589 66.601 1.00 16.60 C

ATOM 2030 CB ILE A 272 -19.882 56.432 65.077 1.00 16.50 C

ATOM 2031 CGl ILE A 272 -18.675 56.915 64.253 1.00 16.42 C

ATOM 2032 CDl ILE A 272 -18.287 58.386 64.458 1.00 16.67 C

ATOM 2033 CG2 ILE A 272 -21.173 57.168 64.668 1.00 16.90 C

ATOM 2034 C ILE A 272 -20.843 56.113 67.396 1.00 17.25 C

ATOM 2035 O ILE A 272 -21.223 54.945 67.316 1.00 17.21 O

ATOM 2036 N LEU A 273 -21.436 57.017 68.174 1.00 18.29 N

ATOM 2037 CA LEU A 273 -22.626 56.707 68.969 1.00 19.43 C

ATOM 2038 CB LEU A 273 -22.911 57.831 69.971 1.00 19.30 C

ATOM 2039 CG LEU A 273 -21.972 58.028 71.164 1.00 18.99 C

ATOM 2040 CDl LEU A 273 -22.401 59.264 71.957 1.00 18.99 C

ATOM 2041 CD2 LEU A 273 -21.951 56.799 72.058 1.00 18.39 C

ATOM 2042 C LEU A 273 -23.851 56.506 68.084 1.00 20.48 C

ATOM 2043 O LEU A 273 -24.101 57.306 67.183 1.00 20.70 O

ATOM 2044 N SER A 274 -24.606 55.441 68.349 1.00 21.88 N

ATOM 2045 CA SER A 274 -25.857 55.168 67.629 1.00 23.45 C

ATOM 2046 CB SER A 274 -26.310 53.727 67.866 1.00 23.30 C

ATOM 2047 OG SER A 274 -25.368 52.805 67.346 1.00 23.75 O

ATOM 2048 C SER A 274 -26.964 56.139 68.048 1.00 24.45 C

ATOM 2049 O SER A 274 -27.874 56.440 67.268 1.00 24.82 O

ATOM 2050 N ASN A 275 -26.877 56.614 69.290 1.00 25.61 N

ATOM 2051 CA ASN A 275 -27.791 57.617 69.826 1.00 26.82 C

ATOM 2052 CB ASN A 275 -28.813 56.956 70.759 1.00 26.98 C

ATOM 2053 CG ASN A 275 -29.968 57.880 71.136 1.00 28.03 C

ATOM 2054 ODl ASN A 275 -30.030 59.042 70.725 1.00 29.20 O

ATOM 2055 ND2 ASN A 275 -30.894 57.356 71.930 1.00 29.25 N

ATOM 2056 C ASN A 275 -26.988 58.697 70.558 1.00 27.27 C

ATOM 2057 O ASN A 275 -26.444 58.438 71.637 1.00 27.39 O

ATOM 2058 N PRO A 276 -26.899 59.906 69.962 1.00 27.84 N

ATOM 2059 CA PRO A 276 -26.089 61.032 70.451 1.00 28.11 C

ATOM 2060 CB PRO A 276 -26.455 62.169 69.489 1.00 28.23 C

ATOM 2061 CG PRO A 276 -26.875 61.479 68.245 1.00 28.25 C

ATOM 2062 CD PRO A 276 -27.598 60.253 68.710 1.00 27.90 C

ATOM 2063 C PRO A 276 -26.349 61.465 71.897 1.00 28.31 C

ATOM 2064 O PRO A 276 -25.500 62.138 72.491 1.00 28.54 O

ATOM 2065 N SER A 277 -27.501 61.100 72.455 1.00 28.41 N

ATOM 2066 CA SER A 277 -27.791 61.412 73.854 1.00 28.39 C

ATOM 2067 CB SER A 277 -29.073 62.236 73.982 1.00 28.65 C

ATOM 2068 OG SER A 277 -28.967 63.158 75.060 1.00 30.30 O

ATOM 2069 C SER A 277 -27.831 60.163 74.738 1.00 27.85 C

ATOM 2070 O SER A 277 -28.376 .177 75.847 1.00 27.88 O

ATOM 2071 N ASN A 278 -27.249 59.084 74.221 1.00 27.13 N W2025-7029WO / AM102903-PCT

ATOM 2072 CA ASN A 278 -26.922 57 .900 75.005 .00 26.34 C

ATOM 2073 CB ASN A 278 -27.534 56 .654 74.365 .00 26.66 C

ATOM 2074 CG ASN A 278 -27.460 55.431 75.262 .00 27.51 C

ATOM 2075 ODl ASN A 278 -26.707 55.394 76.239 .00 28.79 O

ATOM 2076 ND2 ASN A 278 -28.246 54.414 74.926 .00 28.93 N

ATOM 2077 C ASN A 278 -25.397 57.816 75.033 .00 25.42 C

ATOM 2078 O ASN A 278 -24.774 57.392 74.055 .00 25.31 O

ATOM 2079 N THR A 279 -24.803 58.233 76.152 .00 24.40 N

ATOM 2080 CA THR A 279 -23.378 58.586 76.187 .00 23.28 C

ATOM 2081 CB THR A 279 -23.195 60.114 76.343 .00 23.30 C

ATOM 2082 OGl THR A 279 -23.669 60.513 77.635 .00 23.07 O

ATOM 2083 CG2 THR A 279 -23.950 60.879 75.257 .00 23.08 C

ATOM 2084 C THR A 279 -22.557 57.924 77.300 .00 22.63 C

ATOM 2085 O THR A 279 -21.398 58.284 77.506 1.00 22.30 O

ATOM 2086 N GLY A 280 -23.157 56.983 78.022 1.00 21.89 N

ATOM 2087 CA GLY A 280 -22.468 56.291 79.108 1.00 21.54 C

ATOM 2088 C GLY A 280 -21.690 55.080 78.629 1.00 21.05 C

ATOM 2089 O GLY A 280 -21.638 54.800 77.430 1.00 20.85 O

ATOM 2090 N ILE A 281 -21.078 54.366 79.570 1.00 20.84 N

ATOM 2091 CA ILE A 281 -20.413 53.092 79.279 1.00 20.52 C

ATOM 2092 CB ILE A 281 -19.607 52.574 80.514 1.00 20.38 C

ATOM 2093 CGl ILE A 281 -18.448 53.528 80.859 1.00 19.98 C

ATOM 2094 CDl ILE A 281 -17.335 53.633 79.799 1.00 18.11 C

ATOM 2095 CG2 ILE A 281 -19.119 51.131 80.314 1.00 20.09 C

ATOM 2096 C ILE A 281 -21.448 52.055 78.824 1.00 20.72 C

ATOM 2097 O ILE A 281 -22.484 51.873 79.473 1.00 20.90 O

ATOM 2098 N GLY A 282 -21.173 51.400 77.699 1.00 20.41 N

ATOM 2099 CA GLY A 282 -22.072 50.383 77.160 1.00 20.34 C

ATOM 2100 C GLY A 282 -23.140 50.924 76.225 1.00 20.26 C

ATOM 2101 O GLY A 282 -24.064 50.198 75.852 1.00 20.40 O

ATOM 2102 N ALA A 283 -23.012 52.192 75.838 1.00 20.14 N

ATOM 2103 CA ALA A 283 -23.940 52.810 74.886 1.00 20.20 C

ATOM 2104 CB ALA A 283 -23.768 54.317 74.880 1.00 19.99 C

ATOM 2105 C ALA A 283 -23.743 52.241 73.478 1.00 20.12 C

ATOM 2106 O ALA A 283 -22.607 51.994 73.066 1.00 19.99 O

ATOM 2107 N PRO A 284 -24.847 52.028 72.732 1.00 20.19 N

ATOM 2108 CA PRO A 284 -24.741 51.472 71.381 1.00 19.92 C

ATOM 2109 CB PRO A 284 -26.201 51.403 70.909 1.00 20.17 C

ATOM 2110 CG PRO A 284 -26.994 51.362 72.162 1.00 20.63 C

ATOM 2111 CD PRO A 284 -26.254 52.266 73.104 1.00 20.36 C

ATOM 2112 C PRO A 284 -23.923 52.347 70.441 1.00 19.42 C

ATOM 2113 O PRO A 284 -24.077 53.574 70.429 1.00 19.18 O

ATOM 2114 N THR A 285 -23.044 51.703 69.679 1.00 18.64 N

ATOM 2115 CA THR A 285 -22.232 52.377 68.678 1.00 18.43 C

ATOM 2116 CB THR A 285 -20.731 52.362 69.043 1.00 18.46 C

ATOM 2117 OGl THR A 285 -20.281 51.012 69.199 1.00 18.11 O

ATOM 2118 CG2 THR A 285 -20.494 53.125 70.337 1.00 18.55 C

ATOM 2119 C THR A 285 -22.436 51.735 67.308 1.00 .40 C

ATOM 2120 O THR A 285 -22.837 50.570 67.213 1.00 .36 O

ATOM 2121 N SER A 286 -22.159 52.502 66.256 1.00 18.23 N

ATOM 2122 CA SER A 286 -22.348 52.039 64.882 1.00 18.28 C

ATOM 2123 CB SER A 286 -23.185 53.049 64.094 1.00 18.38 C

ATOM 2124 OG SER A 286 -22.501 54.282 63.964 1.00 19.81 O

ATOM 2125 C SER A 286 -21.029 51.773 64.159 1.00 17.67 C

ATOM 2126 O SER A 286 -21.016 51.289 63.024 1.00 18.11 O

ATOM 2127 N GLY A 287 -19.917 52.097 64.812 1.00 16.88 N

ATOM 2128 CA GLY A 287 -18.603 51.861 64.227 1.00 15.87 C

ATOM 2129 C GLY A 287 -17.495 52.640 64.900 1.00 15.11 C

ATOM 2130 O GLY A 287 -17.722 53.330 65.897 1.00 14.78 O

ATOM 2131 N ALA A 288 -16.290 52.512 64.346 1.00 14.84 N

ATOM 2132 CA ALA A 288 -15.109 53.218 64.840 1.00 14.42 C

ATOM 2133 CB ALA A 288 -13.861 52.716 64.137 1.00 14.50 C

ATOM 2134 C ALA A 288 -15.253 54.720 64.640 1.00 14.24 C W2025-7029WO / AM102903-PCT

ATOM 2135 O ALA A 288 15.865 55.168 63.672 1.00 14.06 O

ATOM 2136 N GLY A 289 14.693 55.493 65.565 1.00 13.93 N

ATOM 2137 CA GLY A 289 14.696 56.946 65.441 1.00 13.65 C

ATOM 2138 C GLY A 289 13.656 57.440 64.446 1.00 13.54 C

ATOM 2139 O GLY A 289 12.840 56.646 63.948 1.00 13.44 O

ATOM 2140 N PRO A 290 13.668 58.757 64.153 1.00 13.49 N

ATOM 2141 CA PRO A 290 12.816 59.342 63.116 1.00 13.32 C

ATOM 2142 CB PRO A 290 13.236 60.820 63.098 1.00 13.54 C

ATOM 2143 CG PRO A 290 14.555 60.866 63.777 1.00 13.78 C

ATOM 2144 CD PRO A 290 14.524 59.775 64.790 1.00 13.30 C

ATOM 2145 C PRO A 290 11.329 59.243 63.426 1.00 13.34 C

ATOM 2146 O PRO A 290 10.928 59.401 64.575 1.00 13.19 O

ATOM 2147 N ALA A 291 10.522 58.982 62.401 1.00 13.48 N

ATOM 2148 CA ALA A 291 -9.071 59.118 62.529 1.00 13.53 C

ATOM 2149 CB ALA A 291 -8.385 58.814 61.206 1.00 13.67 C

ATOM 2150 C ALA A 291 -8.715 60.529 62.999 1.00 13.61 C

ATOM 2151 O ALA A 291 -9.413 61.494 62.677 1.00 13.76 O

ATOM 2152 N GLY A 292 -7.635 60.641 63.766 1.00 13.37 N

ATOM 2153 CA GLY A 292 -7.153 61.935 64.217 1.00 13.52 C

ATOM 2154 C GLY A 292 -6.412 62.654 63.104 1.00 13.42 C

ATOM 2155 O GLY A 292 -5.901 62.008 62.188 1.00 13.42 O

ATOM 2156 N PRO A 293 -6.340 63.995 63.178 1.00 13.62 N

ATOM 2157 CA PRO A 293 -5.691 64.786 62.124 1.00 13.64 C

ATOM 2158 CB PRO A 293 -6.116 66.216 62.455 1.00 13.78 C

ATOM 2159 CG PRO A 293 -6.326 66.207 63.937 1.00 13.36 C

ATOM 2160 CD PRO A 293 -6.881 64.848 64.256 1.00 13.37 C

ATOM 2161 C PRO A 293 -4.164 64.672 62.104 1.00 13.77 C

ATOM 2162 O PRO A 293 -3.530 65.088 61.127 1.00 13.99 O

ATOM 2163 N TYR A 294 -3.581 64.123 63.171 1.00 13.30 N

ATOM 2164 CA TYR A 294 -2.132 63.963 63.257 1.00 13.44 C

ATOM 2165 CB TYR A 294 -1.594 64.540 64.570 1.00 13.38 C

ATOM 2166 CG TYR A 294 -1.598 66.048 64.595 1.00 13.18 C

ATOM 2167 CDl TYR A 294 -2.649 66.753 65.182 1.00 13.65 C

ATOM 2168 CEl TYR A 294 -2.658 68.144 65.200 1.00 13.82 C

ATOM 2169 CZ TYR A 294 -1.609 68.843 64.616 1.00 13.95 C

ATOM 2170 OH TYR A 294 -1.600 70.219 64.625 1.00 13.62 O

ATOM 2171 CE2 TYR A 294 -0.558 68.166 64.022 1.00 13.31 C

ATOM 2172 CD2 TYR A 294 -0.556 66.774 64.016 1.00 13.69 C

ATOM 2173 C TYR A 294 -1.676 62.519 63.077 1.00 13.47 C

ATOM 2174 O TYR A 294 -0.862 62.232 62.198 1.00 13.52 O

ATOM 2175 N ALA A 295 -2.196 61.617 63.908 1.00 13.25 N

ATOM 2176 CA ALA A 295 -1.805 60.207 63.850 1.00 13.42 C

ATOM 2177 CB ALA A 295 -2.076 59.519 65.186 1.00 13.33 C

ATOM 2178 C ALA A 295 -2.499 59.470 62.702 1.00 13.44 C

ATOM 2179 O ALA A 295 -1.977 58.473 62.189 1.00 13.45 O

ATOM 2180 N LYS A 296 -3.680 59.961 62.319 1.00 13.36 N

ATOM 2181 CA LYS A 296 -4.443 59.456 61.160 1.00 13.60 C

ATOM 2182 CB LYS A 296 -3.777 59.890 59.841 1.00 14.19 C

ATOM 2183 CG LYS A 296 -3.789 61.432 59.706 1.00 15.32 C

ATOM 2184 CD LYS A 296 -3.117 61.953 58.464 1.00 17.29 C

ATOM 2185 CE LYS A 296 -3.216 63.476 58.385 1.00 18.18 C

ATOM 2186 NZ LYS A 296 -2.701 64.017 57.098 1.00 22.45 N

ATOM 2187 C LYS A 296 -4.786 57.957 61.240 1.00 13.13 C

ATOM 2188 O LYS A 296 -4.785 57.218 60.238 1.00 12.80 O

ATOM 2189 N GLU A 297 -5.116 57.539 62.460 1.00 12.62 N

ATOM 2190 CA GLU A 297 -5.447 56.159 62.770 1.00 12.48 C

ATOM 2191 CB GLU A 297 -4.617 55.664 63.962 1.00 12.41 C

ATOM 2192 CG GLU A 297 -3.106 55.775 63.729 1.00 13.44 C

ATOM 2193 CD GLU A 297 -2.260 55.316 64.903 1.00 12.97 C

ATOM 2194 OEl GLU A 297 -2.695 54.419 65.658 1.00 13.83 O

ATOM 2195 OE2 GLU A 297 -1.143 55.856 65.064 1.00 13.75 O

ATOM 2196 C GLU A 297 -6.931 56.026 63.054 1.00 12.17 C

ATOM 2197 O GLU A 297 -7.438 56.560 64.047 1.00 11.89 O W2025-7029WO / AM102903-PCT

ATOM 2198 N SER A 298 -7.624 55.323 62.163 1.00 11.76 N

ATOM 2199 CA SER A 298 -9.047 55.039 62.328 1.00 11.86 C

ATOM 2200 CB SER A 298 -9.504 54.079 61.224 1.00 12.35 C

ATOM 2201 OG SER A 298 10.819 53.620 61.439 1.00 13.79 O

ATOM 2202 C SER A 298 -9.356 54.476 63.721 1.00 11.37 C

ATOM 2203 O SER A 298 -8.671 53.566 64.202 1.00 10.77 O

ATOM 2204 N GLY A 299 10.369 55.042 64.376 1.00 10.90 N

ATOM 2205 CA GLY A 299 10.795 54.577 65.698 1.00 11.02 C

ATOM 2206 C GLY A 299 -9.832 54.818 66.854 1.00 10.86 C

ATOM 2207 O GLY A 299 10.043 54.309 67.953 1.00 11.68 O

ATOM 2208 N ILE A 300 -8.787 55.607 66.613 1.00 10.84 N

ATOM 2209 CA ILE A 300 -7.744 55.870 67.609 1.00 10.68 C

ATOM 2210 CB ILE A 300 -6.419 55.100 67.269 1.00 10.65 C

ATOM 2211 CGl ILE A 300 -6.620 53.575 67.279 1.00 11.54 C

ATOM 2212 CDl ILE A 300 -6.845 52.981 68.639 1.00 11.69 C

ATOM 2213 CG2 ILE A 300 -5.267 55.520 68.194 1.00 10.17 C

ATOM 2214 C ILE A 300 -7.426 57.363 67.640 1.00 10.70 C

ATOM 2215 O ILE A 300 -7.239 57.975 66.585 1.00 10.40 O

ATOM 2216 N TRP A 301 -7.361 57.939 68.844 1.00 10.43 N

ATOM 2217 CA TRP A 301 -6.821 59.289 69.035 1.00 10.29 C

ATOM 2218 CB TRP A 301 -7.890 60.260 69.540 1.00 10.30 C

ATOM 2219 CG TRP A 301 -8.830 60.788 68.507 1.00 10.65 C

ATOM 2220 CDl TRP A 301 -8.641 60.827 67.150 1.00 11.42 C

ATOM 2221 NEl TRP A 301 -9.734 61.410 66.538 1.00 11.62 N

ATOM 2222 CE2 TRP A 301 10.634 61.784 67.504 1.00 11.08 C

ATOM 2223 CD2 TRP A 301 10.095 61.408 68.757 1.00 10.17 C

ATOM 2224 CE3 TRP A 301 10.829 61.679 69.920 1.00 11.38 C

ATOM 2225 CZ3 TRP A 301 12.074 62.300 69.799 1.00 11.82 C

ATOM 2226 CH2 TRP A 301 12.588 62.656 68.536 1.00 11.38 C

ATOM 2227 CZ2 TRP A 301 11.888 62.403 67.381 1.00 11.41 C

ATOM 2228 C TRP A 301 -5.665 59.296 70.027 1.00 10.11 C

ATOM 2229 O TRP A 301 -5.779 58.755 71.135 1.00 10.14 O

ATOM 2230 N ALA A 302 -4.556 59.918 69.629 1.00 10.00 N

ATOM 2231 CA ALA A 302 -3.445 60.182 70.544 1.00 9.92 C

ATOM 2232 CB ALA A 302 -2.305 60.877 69.811 1.00 10.00 C

ATOM 2233 C ALA A 302 -3.950 61.057 71.685 1.00 9.93 C

ATOM 2234 O ALA A 302 -4.922 61.793 71.514 1.00 9.80 O

ATOM 2235 N TYR A 303 -3.299 60.992 72.845 1.00 9.84 N

ATOM 2236 CA TYR A 303 -3.717 61.848 73.958 1.00 9.91 C

ATOM 2237 CB TYR A 303 -2.804 61.684 75.175 1.00 9.86 C

ATOM 2238 CG TYR A 303 -3.254 62.500 76.368 1.00 9.87 C

ATOM 2239 CDl TYR A 303 -4.509 62.287 76.952 1.00 9.63 C

ATOM 2240 CEl TYR A 303 -4.930 63.035 78.050 1.00 10.22 C

ATOM 2241 CZ TYR A 303 -4.091 64.007 78.572 1.00 10.59 C

ATOM 2242 OH TYR A 303 -4.503 64.752 79.651 1.00 10.62 O

ATOM 2243 CE2 TYR A 303 -2.838 64.232 78.018 1.00 10.41 C

ATOM 2244 CD2 TYR A 303 -2.430 63.481 76.914 1.00 9.66 C

ATOM 2245 C TYR A 303 -3.823 63.319 73.541 1.00 10.04 C

ATOM 2246 O TYR A 303 -4.805 63.992 73.865 1.00 9.97 O

ATOM 2247 N TYR A 304 -2.837 63.811 72.791 1.00 10.39 N

ATOM 2248 CA TYR A 304 -2.865 65.213 72.382 1.00 10.40 C

ATOM 2249 CB TYR A 304 -1.497 65.693 71.867 1.00 10.53 C

ATOM 2250 CG TYR A 304 -0.979 65.060 70.589 1.00 10.87 C

ATOM 2251 CDl TYR A 304 -0.038 64.029 70.628 1.00 11.39 C

ATOM 2252 CEl TYR A 304 0.465 63.464 69.449 1.00 10.82 C

ATOM 2253 CZ TYR A 304 0.028 63.944 68.222 1.00 10.51 C

ATOM 2254 OH TYR A 304 0.506 63.401 67.048 1.00 9.84 O

ATOM 2255 CE2 TYR A 304 -0.893 64.979 68.160 1.00 10.67 C

ATOM 2256 CD2 TYR A 304 -1.386 65.535 69.338 1.00 11.60 C

ATOM 2257 C TYR A 304 -4.024 65.517 71.417 1.00 10.61 C

ATOM 2258 O TYR A 304 -4.600 66.611 71.450 1.00 10.78 O

ATOM 2259 N GLU A 305 -4.383 64.533 70.593 1.00 10.57 N

ATOM 2260 CA GLU A 305 -5.574 64.629 69.744 1.00 10.90 C W2025-7029WO / AM102903-PCT

ATOM 2261 CB GLU A 305 -5.628 63.475 68.737 1.00 11.10 C

ATOM 2262 CG GLU A 305 -4.608 63.623 67.610 1.00 10.56 C

ATOM 2263 CD GLU A 305 -4.575 62.438 66.650 1.00 10.71 C

ATOM 2264 OEl GLU A 305 -4.844 61.289 67.072 1.00 10.57 O

ATOM 2265 OE2 GLU A 305 -4.263 62.661 65.461 1.00 10.20 O

ATOM 2266 C GLU A 305 -6.860 64.683 70.575 1.00 11.08 C

ATOM 2267 O GLU A 305 -7.807 65.382 70.214 1.00 11.36 O

ATOM 2268 N ILE A 306 -6.886 63.943 71.682 1.00 11.05 N

ATOM 2269 CA ILE A 306 -8.022 63.972 72.607 1.00 10.88 C

ATOM 2270 CB ILE A 306 -7.951 62.829 73.653 1.00 10.75 C

ATOM 2271 CGl ILE A 306 -7.996 61.467 72.951 1.00 10.39 C

ATOM 2272 CDl ILE A 306 -7.603 60.283 73.844 1.00 10.91 C

ATOM 2273 CG2 ILE A 306 -9.104 62.922 74.652 1.00 10.65 C

ATOM 2274 C ILE A 306 -8.125 65.341 73.284 1.00 11.14 C

ATOM 2275 O ILE A 306 -9.221 65.864 73.485 1.00 11.06 O

ATOM 2276 N CYS A 307 -6.984 65.934 73.610 1.00 11.38 N

ATOM 2277 CA CYS A 307 -6.982 67.271 74.201 1.00 12.04 C

ATOM 2278 CB CYS A 307 -5.573 67.679 74.598 1.00 12.02 C

ATOM 2279 SG CYS A 307 -5.023 66.776 76.052 1.00 13.64 S

ATOM 2280 C CYS A 307 -7.645 68.313 73.290 1.00 12.13 C

ATOM 2281 O CYS A 307 -8.364 69.189 73.770 1.00 11.84 O

ATOM 2282 N THR A 308 -7.420 68.196 71.983 1.00 12.30 N

ATOM 2283 CA THR A 308 -8.107 69.045 71.003 1.00 12.70 C

ATOM 2284 CB THR A 308 -7.601 68.767 69.574 1.00 12.94 C

ATOM 2285 OGl THR A 308 -6.182 68.972 69.522 1.00 12.75 O

ATOM 2286 CG2 THR A 308 -8.291 69.677 68.557 1.00 13.10 C

ATOM 2287 C THR A 308 -9.626 68.855 71.076 1.00 13.15 C

ATOM 2288 O THR A 308 10.382 69.834 71.085 1.00 13.10 O

ATOM 2289 N PHE A 309 10.058 67.595 71.141 1.00 13.41 N

ATOM 2290 CA PHE A 309 11.470 67.237 71.284 1.00 13.79 C

ATOM 2291 CB PHE A 309 11.599 65.712 71.383 1.00 13.74 C

ATOM 2292 CG PHE A 309 13.011 65.197 71.340 1.00 13.17 C

ATOM 2293 CDl PHE A 309 13.866 65.526 70.289 1.00 13.29 C

ATOM 2294 CEl PHE A 309 15.168 65.020 70.243 1.00 14.34 C

ATOM 2295 CZ PHE A 309 15.621 64.158 71.246 1.00 13.44 C

ATOM 2296 CE2 PHE A 309 14.772 63.816 72.292 1.00 12.80 C

ATOM 2297 CD2 PHE A 309 13.473 64.330 72.331 1.00 12.77 C

ATOM 2298 C PHE A 309 12.093 67.921 72.508 1.00 14.38 C

ATOM 2299 O PHE A 309 13.185 68.488 72.420 1.00 14.29 O

ATOM 2300 N LEU A 310 11.376 67.881 73.630 1.00 14.66 N

ATOM 2301 CA LEU A 310 11.817 68.510 74.879 1.00 15.46 C

ATOM 2302 CB LEU A 310 10.915 68.081 76.041 1.00 15.41 C

ATOM 2303 CG LEU A 310 10.935 66.596 76.428 1.00 15.16 C

ATOM 2304 CDl LEU A 310 -9.844 66.297 77.437 1.00 14.86 C

ATOM 2305 CD2 LEU A 310 12.298 66.183 76.966 1.00 16.78 C

ATOM 2306 C LEU A 310 11.865 70.036 74.780 1.00 16.09 C

ATOM 2307 O LEU A 310 12.802 70.665 75.280 1.00 16.37 O

ATOM 2308 N LYS A 311 10.852 70.618 74.137 1.00 16.64 N

ATOM 2309 CA LYS A 311 10.792 72.063 73.879 1.00 17.56 C

ATOM 2310 CB LYS A 311 -9.470 72.433 73.205 1.00 17.77 C

ATOM 2311 CG LYS A 311 -8.287 72.626 74.141 1.00 19.17 C

ATOM 2312 CD LYS A 311 -7.027 72.938 73.333 1.00 20.89 C

ATOM 2313 CE LYS A 311 -5.971 73.626 74.188 1.00 22.64 C

ATOM 2314 NZ LYS A 311 -4.671 73.779 73.465 1.00 23.73 N

ATOM 2315 C LYS A 311 11.949 72.543 73.001 1.00 17.69 C

ATOM 2316 O LYS A 311 12.477 73.642 73.203 1.00 17.76 O

ATOM 2317 N ASN A 312 12.339 71.709 72.036 1.00 17.75 N

ATOM 2318 CA ASN A 312 13.390 72.046 71.076 1.00 18.07 C

ATOM 2319 CB ASN A 312 13.201 71.256 69.776 1.00 18.43 C

ATOM 2320 CG ASN A 312 11.951 71.661 69.019 1.00 19.19 C

ATOM 2321 ODl ASN A 312 11.359 72.714 69.275 1.00 20.37 O

ATOM 2322 ND2 ASN A 312 11.537 70.815 68.077 1.00 21.12 N

ATOM 2323 C ASN A 312 14.820 71.868 71.589 1.00 17.76 C W2025-7029WO / AM102903-PCT

ATOM 2324 O ASN A 312 -15.776 71 .983 70.818 .00 17.77 O

ATOM 2325 N GLY A 313 -14.961 71.560 72.875 .00 17.54 N

ATOM 2326 CA GLY A 313 -16.265 71.571 73.533 .00 17.14 C

ATOM 2327 C GLY A 313 -16.877 70.246 73.944 .00 16.98 C

ATOM 2328 O GLY A 313 -18.025 70.214 74.403 .00 17.13 O

ATOM 2329 N ALA A 314 -16.135 69.150 73.775 .00 16.46 N

ATOM 2330 CA ALA A 314 -16.624 67.837 74.187 .00 15.89 C

ATOM 2331 CB ALA A 314 -15.626 66.759 73.833 .00 15.56 C

ATOM 2332 C ALA A 314 -16.895 67.822 75.685 .00 15.67 C

ATOM 2333 O ALA A 314 -16.195 68.485 76.454 .00 15.90 O

ATOM 2334 N THR A 315 -17.916 67.069 76.085 .00 15.49 N

ATOM 2335 CA THR A 315 -18.257 66.924 77.496 .00 15.37 C

ATOM 2336 CB THR A 315 -19.742 66.570 77.676 .00 15.76 C

ATOM 2337 OGl THR A 315 -20.549 67.619 77.125 1.00 15.52 O

ATOM 2338 CG2 THR A 315 -20.086 66.390 79.155 1.00 16.29 C

ATOM 2339 C THR A 315 -17.372 65.862 78.147 1.00 15.27 C

ATOM 2340 O THR A 315 -17.276 64.737 77.656 1.00 15.09 O

ATOM 2341 N GLN A 316 -16.728 66.235 79.250 1.00 14.98 N

ATOM 2342 CA GLN A 316 -15.898 65.314 80.013 1.00 14.93 C

ATOM 2343 CB GLN A 316 -14.964 66.088 80.945 1.00 15.02 C

ATOM 2344 CG GLN A 316 -14.124 65.211 81.859 1.00 17.15 C

ATOM 2345 CD GLN A 316 -12.873 .695 81.180 1.00 18.93 C

ATOM 2346 OEl GLN A 316 -11.903 65.433 81.003 1.00 19.51 O

ATOM 2347 NE2 GLN A 316 -12.886 63.422 80.802 1.00 19.21 N

ATOM 2348 C GLN A 316 -16.757 .355 80.830 1.00 14.35 C

ATOM 2349 O GLN A 316 -17.699 .766 81.520 1.00 14.44 O

ATOM 2350 N GLY A 317 -16.427 63.073 80.741 1.00 13.62 N

ATOM 2351 CA GLY A 317 -17.025 62.061 81.595 1.00 12.67 C

ATOM 2352 C GLY A 317 -15.961 61.420 82.467 1.00 12.48 C

ATOM 2353 O GLY A 317 -14.780 61.412 82.115 1.00 12.44 O

ATOM 2354 N TRP A 318 -16.378 .909 83.620 1.00 11.83 N

ATOM 2355 CA TRP A 318 -15.506 .096 84.458 1.00 11.41 C

ATOM 2356 CB TRP A 318 -15.117 60.823 85.753 1.00 11.39 C

ATOM 2357 CG TRP A 318 -14.156 60.022 86.587 1.00 11.53 C

ATOM 2358 CDl TRP A 318 -14.446 59.302 87.711 1.00 11.47 C

ATOM 2359 NEl TRP A 318 -13.310 58.677 88.180 1.00 11.58 N

ATOM 2360 CE2 TRP A 318 -12.261 58.983 87.351 1.00 11.58 C

ATOM 2361 CD2 TRP A 318 -12.760 59.820 86.329 1.00 11.14 C

ATOM 2362 CE3 TRP A 318 -11.874 60.284 85.342 1.00 11.32 C

ATOM 2363 CZ3 TRP A 318 -10.542 59.899 85.405 1.00 11.18 C

ATOM 2364 CH2 TRP A 318 -10.076 59.054 86.433 1.00 10.87 C

ATOM 2365 CZ2 TRP A 318 -10.916 58.594 87.415 1.00 11.04 C

ATOM 2366 C TRP A 318 -16.201 58.769 84.755 1.00 11.40 C

ATOM 2367 O TRP A 318 -17.310 58.740 85.295 1.00 11.24 O

ATOM 2368 N ASP A 319 -15.541 57.679 84.369 1.00 10.94 N

ATOM 2369 CA ASP A 319 -16.010 56.320 84.617 1.00 10.76 C

ATOM 2370 CB ASP A 319 -15.483 55.410 83.489 1.00 10.11 C

ATOM 2371 CG ASP A 319 -15.867 53.943 83.642 1.00 10.31 C

ATOM 2372 ODl ASP A 319 -15.616 53.199 82.668 1.00 9.74 O

ATOM 2373 OD2 ASP A 319 -16.390 53.509 84.692 1.00 9.83 O

ATOM 2374 C ASP A 319 -15.500 55.910 86.001 1.00 10.56 C

ATOM 2375 O ASP A 319 -14.402 55.360 86.146 1.00 11.08 O

ATOM 2376 N ALA A 320 -16.303 56.203 87.025 1.00 10.73 N

ATOM 2377 CA ALA A 320 -15.883 56.020 88.414 1.00 10.61 C

ATOM 2378 CB ALA A 320 -16.921 56.605 89.392 1.00 10.73 C

ATOM 2379 C ALA A 320 -15.496 54.590 88.804 1.00 10.65 C

ATOM 2380 O ALA A 320 -14.445 54.408 89.419 1.00 10.51 O

ATOM 2381 N PRO A 321 -16.325 53.571 88.453 1.00 10.76 N

ATOM 2382 CA PRO A 321 -15.935 52.201 88.830 1.00 10.83 C

ATOM 2383 CB PRO A 321 -17.038 51.324 88.223 1.00 11.06 C

ATOM 2384 CG PRO A 321 -18.178 52.230 87.967 1.00 11.61 C

ATOM 2385 CD PRO A 321 -17.627 53.602 87.754 1.00 10.94 C

ATOM 2386 C PRO A 321 -14.591 51.774 88.250 1.00 10.68 C W2025-7029WO / AM102903-PCT

ATOM 2387 O PRO A 321 -13.868 51 002 88.873 .00 10.74 O

ATOM 2388 N GLN A 322 -14.265 52 294 87.068 .00 10.32 N

ATOM 2389 CA GLN A 322 -13.098 51 831 86.318 .00 10.40 C

ATOM 2390 CB GLN A 322 -13.500 51 563 84.865 .00 10.08 C

ATOM 2391 CG GLN A 322 -14.644 50 552 84.759 .00 10.61 C

ATOM 2392 CD GLN A 322 -14.792 49 956 83.382 .00 10.45 C

ATOM 2393 OEl GLN A 322 -14.363 48 821 83.126 .00 12.07 O

ATOM 2394 NE2 GLN A 322 -15.403 50 704 82.484 .00 9.19 N

ATOM 2395 C GLN A 322 -11.898 52 783 86.411 .00 10.23 C

ATOM 2396 O GLN A 322 -10.800 52 460 85.933 .00 10.03 O

ATOM 2397 N GLU A 323 -12.120 53 940 87.045 .00 10.29 N

ATOM 2398 CA GLU A 323 -11.079 54 947 87.318 .00 10.68 C

ATOM 2399 CB GLU A 323 -10.009 54 412 88.284 .00 11.03 C

ATOM 2400 CG GLU A 323 -10.546 53.900 89.614 1.00 13.45 C

ATOM 2401 CD GLU A 323 -10.893 54.995 90.607 1.00 16.47 C

ATOM 2402 OEl GLU A 323 -11.101 54.646 91.789 1.00 19.73 O

ATOM 2403 OE2 GLU A 323 -10.965 56.187 90.233 1.00 17.26 O

ATOM 2404 C GLU A 323 -10.421 55.491 86.053 1.00 10.42 C

ATOM 2405 O GLU A 323 -9.207 55.726 86.019 1.00 10.05 O

ATOM 2406 N VAL A 324 -11.235 55.708 85.024 1.00 9.80 N

ATOM 2407 CA VAL A 324 -10.745 56.247 83.751 1.00 9.78 C

ATOM 2408 CB VAL A 324 -10.466 55.123 82.715 1.00 9.65 C

ATOM 2409 CGl VAL A 324 -9.085 54.498 82.942 1.00 9.86 C

ATOM 2410 CG2 VAL A 324 -11.557 54.064 82.752 1.00 9.72 C

ATOM 2411 C VAL A 324 -11.724 57.269 83.161 1.00 9. .65 C

ATOM 2412 O VAL A 324 -12.928 57.176 83.402 1.00 9..32 O

ATOM 2413 N PRO A 325 -11.202 58.257 82.409 1.00 9.40 N

ATOM 2414 CA PRO A 325 -12.040 59.277 81.778 1.00 9.35 C

ATOM 2415 CB PRO A 325 -11.044 400 81.486 1.00 9.40 C

ATOM 2416 CG PRO A 325 -9.764 59.664 81.196 1.00 9.61 C

ATOM 2417 CD PRO A 325 -9.768 58.478 82.131 1.00 47 C

ATOM 2418 C PRO A 325 -12.664 58.812 80.466 1.00 42 C

ATOM 2419 O PRO A 325 -12.194 57.852 79.855 1.00 9.02 O

ATOM 2420 N TYR A 326 -13.721 59.502 80.053 1.00 9.78 N

ATOM 2421 CA TYR A 326 -14.227 59.424 78.684 1.00 10.45 C

ATOM 2422 CB TYR A 326 -15.303 58.338 78.525 1.00 10.49 C

ATOM 2423 CG TYR A 326 -16.585 58.568 79.300 1.00 11.14 C

ATOM 2424 CDl TYR A 326 -17.699 59.148 78.690 1.00 12.15 C

ATOM 2425 CEl TYR A 326 -18.888 59.348 79.397 1.00 12.60 C

ATOM 2426 CZ TYR A 326 -18.967 58.946 80.721 1.00 12.92 C

ATOM 2427 OH TYR A 326 -20.132 59.129 81.432 1.00 14.13 O

ATOM 2428 CE2 TYR A 326 -17.881 58.355 81.343 1.00 12.39 C

ATOM 2429 CD2 TYR A 326 -16.697 58.168 80.631 1.00 11.57 C

ATOM 2430 C TYR A 326 -14.744 60.800 78.279 1.00 10.87 C

ATOM 2431 O TYR A 326 -14.877 61.688 79.121 1.00 10.86 O

ATOM 2432 N ALA A 327 -15.021 76.994 1.00 11.37 N

ATOM 2433 CA ALA A 327 -15.496 62. 285 76.516 1.00 12.00 C

ATOM 2434 CB ALA A 327 -14.330 63.197 76.186 1.00 11.80 C

ATOM 2435 C ALA A 327 -16.378 62.080 75.304 1.00 12.67 C

ATOM 2436 O ALA A 327 -16.214 61.108 74.576 1.00 12.30 O

ATOM 2437 N TYR A 328 -17.329 62. 75.104 1.00 13.49 N

ATOM 2438 CA TYR A 328 -18.267 62. 851 73.996 1.00 14.41 C

ATOM 2439 CB TYR A 328 -19.463 61.978 74.404 1.00 14.57 C

ATOM 2440 CG TYR A 328 -20.238 62.496 75.600 1.00 15.32 C

ATOM 2441 CDl TYR A 328 -19.917 62.090 76.900 1.00 15.83 C

ATOM 2442 CEl TYR A 328 -20.628 62.569 78.001 1.00 15.90 C

ATOM 2443 C Z TYR A 328 -21.673 63.460 77.801 1.00 16.82 C

ATOM 2444 OH TYR A 328 -22.384 63.939 78.874 1.00 16.62 O

ATOM 2445 CE2 TYR A 328 -22.010 63.876 76.522 1.00 16.47 C

ATOM 2446 CD2 TYR A 328 -21.297 63.392 75.432 1.00 16.03 C

ATOM 2447 C TYR A 328 -18.728 64.208 73.469 1.00 15.23 C

ATOM 2448 O TYR A 328 -18.775 65.189 74.213 1.00 15.22 O

ATOM 2449 N GLN A 329 -19.050 64.245 72.179 1.00 15.99 N W2025-7029WO / AM102903-PCT

ATOM 2450 CA GLN A 329 19.610 65.425 71.517 1.00 16.92 C

ATOM 2451 CB GLN A 329 18.511 66.423 71.143 1.00 17.06 C

ATOM 2452 CG GLN A 329 19.026 67.792 70.673 1.00 18.01 C

ATOM 2453 CD GLN A 329 17.914 68.798 70.406 1.00 19.47 C

ATOM 2454 OEl GLN A 329 16.972 68.529 69.656 1.00 21.15 O

ATOM 2455 NE2 GLN A 329 18.029 69.974 71.009 1.00 20.98 N

ATOM 2456 C GLN A 329 20.324 64.944 70.262 1.00 17.47 C

ATOM 2457 O GLN A 329 19.749 64.190 69.469 1.00 17.15 O

ATOM 2458 N GLY A 330 21.570 65.379 70.081 1.00 17.84 N

ATOM 2459 CA GLY A 330 22.394 64.903 68.966 1.00 18.33 C

ATOM 2460 C GLY A 330 22.494 63.385 68.987 1.00 18.49 C

ATOM 2461 O GLY A 330 22.919 62.798 69.983 1.00 18.40 O

ATOM 2462 N ASN A 331 22.084 62.749 67.892 1.00 18.41 N

ATOM 2463 CA ASN A 331 22.097 61.289 67.811 1.00 18.35 C

ATOM 2464 CB ASN A 331 22.799 60.822 66.523 1.00 18.78 C

ATOM 2465 CG ASN A 331 22.034 61.191 65.257 1.00 19.88 C

ATOM 2466 ODl ASN A 331 21.164 62.062 65.260 1.00 22.17 O

ATOM 2467 ND2 ASN A 331 22.369 60.525 64.161 1.00 21.55 N

ATOM 2468 C ASN A 331 20.704 60.649 67.944 1.00 17.77 C

ATOM 2469 O ASN A 331 20.490 59.521 67.492 1.00 18.02 O

ATOM 2470 N VAL A 332 19.770 61.369 68.561 1.00 16.88 N

ATOM 2471 CA VAL A 332 18.417 60.847 68.788 1.00 15.82 C

ATOM 2472 CB VAL A 332 17.325 61.733 68.118 1.00 16.03 C

ATOM 2473 CGl VAL A 332 15.921 61.210 68.429 1.00 15.93 C

ATOM 2474 CG2 VAL A 332 17.531 61.788 66.610 1.00 16.07 C

ATOM 2475 C VAL A 332 18.143 60.671 70.286 1.00 15.03 C

ATOM 2476 O VAL A 332 18.396 61.576 71.084 1.00 14.79 O

ATOM 2477 N TRP A 333 17.623 59.500 70.647 1.00 13.88 N

ATOM 2478 CA TRP A 333 17.350 59.131 72.039 1.00 12.79 C

ATOM 2479 CB TRP A 333 18.344 58.054 72.463 1.00 12.79 C

ATOM 2480 CG TRP A 333 18.420 57.724 73.932 1.00 12.58 C

ATOM 2481 CDl TRP A 333 19.337 58.200 74.823 1.00 12.02 C

ATOM 2482 NEl TRP A 333 19.125 57.654 76.064 1.00 12.00 N

ATOM 2483 CE2 TRP A 333 18.065 56.789 75.999 1.00 12.38 C

ATOM 2484 CD2 TRP A 333 17.594 56.798 74.668 1.00 12.50 C

ATOM 2485 CE3 TRP A 333 16.502 55.984 74.331 1.00 13.05 C

ATOM 2486 CZ3 TRP A 333 15.920 55.199 75.328 1.00 11.77 C

ATOM 2487 CH2 TRP A 333 16.413 55.214 76.645 1.00 12.66 C

ATOM 2488 CZ2 TRP A 333 17.481 55.998 77.001 1.00 12.15 C

ATOM 2489 C TRP A 333 15.941 58.558 72.088 1.00 12.03 C

ATOM 2490 O TRP A 333 15.582 57.753 71.233 1.00 11.82 O

ATOM 2491 N VAL A 334 15.153 58.966 73.080 1.00 11.24 N

ATOM 2492 CA VAL A 334 13.797 58.433 73.249 1.00 10.39 C

ATOM 2493 CB VAL A 334 12.690 59.443 72.776 1.00 10.39 C

ATOM 2494 CGl VAL A 334 12.724 60.749 73.578 1.00 10.10 C

ATOM 2495 CG2 VAL A 334 11.293 58.807 72.837 1.00 10.18 C

ATOM 2496 C VAL A 334 13.539 57.952 74.678 1.00 10.23 C

ATOM 2497 O VAL A 334 13.831 58.660 75.651 1.00 9.75 O

ATOM 2498 N GLY A 335 13.004 56.737 74.787 1.00 9.56 N

ATOM 2499 CA GLY A 335 12.532 56.191 76.065 1.00 9.58 C

ATOM 2500 C GLY A 335 11.015 56.251 76.085 1.00 9.52 C

ATOM 2501 O GLY A 335 10.360 55.831 75.125 1.00 9.50 O

ATOM 2502 N TYR A 336 10.441 56.773 77.170 1.00 9.13 N

ATOM 2503 CA TYR A 336 -9.005 57.044 77.194 1.00 8.92 C

ATOM 2504 CB TYR A 336 -8.693 58.331 76.410 1.00 9.26 C

ATOM 2505 CG TYR A 336 -9.249 59.593 77.041 1.00 9.30 C

ATOM 2506 CDl TYR A 336 10.612 59.886 76.975 1.00 9.86 C

ATOM 2507 CEl TYR A 336 11.128 61.034 77.559 1.00 10.01 C

ATOM 2508 CZ TYR A 336 10.279 61.914 78.207 1.00 9.70 C

ATOM 2509 OH TYR A 336 10.796 63.050 78.780 1.00 10.33 O

ATOM 2510 CE2 TYR A 336 -8.916 61.659 78.281 1.00 9.48 C

ATOM 2511 CD2 TYR A 336 -8.409 60.495 77.699 1.00 9.72 C

ATOM 2512 C TYR A 336 -8.420 57.118 78.608 1.00 8.70 C W2025-7029WO / AM102903-PCT

ATOM 2513 O TYR A 336 -9.082 56.742 79.578 1.00 8.40 O

ATOM 2514 N ASP A 337 -7.175 57.587 78.697 1.00 8.63 N

ATOM 2515 CA ASP A 337 -6.492 57.816 79.968 1.00 8.70 C

ATOM 2516 CB ASP A 337 -5.341 56.828 80.158 1.00 8.84 C

ATOM 2517 CG ASP A 337 -5.804 55.489 80.685 1.00 8.66 C

ATOM 2518 ODl ASP A 337 -6.168 54.618 79.869 1.00 9.11 O

ATOM 2519 OD2 ASP A 337 -5.801 55.308 81.922 1.00 9.18 O

ATOM 2520 C ASP A 337 -5.944 59.232 80.057 1.00 9.05 C

ATOM 2521 O ASP A 337 -5.484 59.800 79.059 1.00 9.27 O

ATOM 2522 N ASN A 338 -5.989 59.794 81.262 1.00 8.87 N

ATOM 2523 CA ASN A 338 -5.452 61.125 81.510 1.00 9.09 C

ATOM 2524 CB ASN A 338 -6.580 62.163 81.650 1.00 9.01 C

ATOM 2525 CG ASN A 338 -7.535 61.865 82.806 1.00 9.23 C

ATOM 2526 ODl ASN A 338 -7.287 60.984 83.632 1.00 8.96 O

ATOM 2527 ND2 ASN A 338 -8.636 62.613 82.869 1.00 9.06 N

ATOM 2528 C ASN A 338 -4.505 61.133 82.708 1.00 9.15 C

ATOM 2529 O ASN A 338 -4.125 60.069 83.201 1.00 9.33 O

ATOM 2530 N VAL A 339 -4.113 62.322 83.164 1.00 9.52 N

ATOM 2531 CA VAL A 339 -3.204 62.440 84.312 1.00 9.88 C

ATOM 2532 CB VAL A 339 -2.856 63.925 84.605 1.00 9.76 C

ATOM 2533 CGl VAL A 339 -2.103 64.075 85.930 1.00 9.94 C

ATOM 2534 CG2 VAL A 339 -2.050 64.519 83.452 1.00 10.04 C

ATOM 2535 C VAL A 339 -3.801 61.751 85.548 1.00 10.22 C

ATOM 2536 O VAL A 339 -3.124 60.987 86.242 1.00 9.97 O

ATOM 2537 N LYS A 340 -5.083 62.010 85.787 1.00 10.66 N

ATOM 2538 CA LYS A 340 -5.798 61.444 86.932 1.00 11.29 C

ATOM 2539 CB LYS A 340 -7.238 61.962 86.951 1.00 11.52 C

ATOM 2540 CG LYS A 340 -8.036 61.561 88.183 1.00 13.40 C

ATOM 2541 CD LYS A 340 -9.399 62.244 88.190 1.00 15.90 C

ATOM 2542 CE LYS A 340 10.252 61.754 89.351 1.00 18.29 C

ATOM 2543 NZ LYS A 340 11.636 62.310 89.278 1.00 20.39 N

ATOM 2544 C LYS A 340 -5.766 59.911 86.939 1.00 11.20 C

ATOM 2545 O LYS A 340 -5.404 59.299 87.951 1.00 11.31 O

ATOM 2546 N SER A 341 -6.129 59.299 85.811 1.00 11.09 N

ATOM 2547 CA SER A 341 -6.178 57.838 85.702 1.00 10.66 C

ATOM 2548 CB SER A 341 -6.966 57.393 84.462 1.00 11.07 C

ATOM 2549 OG SER A 341 -6.262 57.666 83.263 1.00 9.73 O

ATOM 2550 C SER A 341 -4.787 57.195 85.733 1.00 10.79 C

ATOM 2551 O SER A 341 -4.606 56.135 86.337 1.00 10.76 O

ATOM 2552 N PHE A 342 -3.810 57.836 85.090 1.00 10.65 N

ATOM 2553 CA PHE A 342 -2.424 57.376 85.167 1.00 11.10 C

ATOM 2554 CB PHE A 342 -1.502 58.234 84.282 1.00 10.66 C

ATOM 2555 CG PHE A 342 -1.242 57.647 82.914 1.00 10.25 C

ATOM 2556 CDl PHE A 342 -2.261 57.027 82.189 1.00 10.50 C

ATOM 2557 CEl PHE A 342 -2.019 56.486 80.924 1.00 10.13 C

ATOM 2558 CZ PHE A 342 -0.752 56.570 80.368 1.00 9.79 C

ATOM 2559 CE2 PHE A 342 0.277 57.191 81.075 1.00 9.25 C

ATOM 2560 CD2 PHE A 342 0.027 57.728 82.343 1.00 10.33 C

ATOM 2561 C PHE A 342 -1.944 57.373 86.619 1.00 11.80 C

ATOM 2562 O PHE A 342 -1.287 56.427 87.063 1.00 11.92 O

ATOM 2563 N ASP A 343 -2.297 58.417 87.367 1.00 12.26 N

ATOM 2564 CA ASP A 343 -1.888 58.497 88.763 1.00 13.05 C

ATOM 2565 CB ASP A 343 -2.186 59.869 89.350 1.00 13.75 C

ATOM 2566 CG ASP A 343 -1.398 60.126 90.609 1.00 16.30 C

ATOM 2567 ODl ASP A 343 -0.151 60.229 90.517 1.00 19.56 O

ATOM 2568 OD2 ASP A 343 -2.021 60.208 91.689 1.00 19.85 O

ATOM 2569 C ASP A 343 -2.515 57.413 89.637 1.00 12.85 C

ATOM 2570 O ASP A 343 -1.822 56.780 90.442 1.00 12.67 O

ATOM 2571 N ILE A 344 -3.817 57.197 89.461 1.00 12.65 N

ATOM 2572 CA ILE A 344 -4.555 56.155 90.179 1.00 12.11 C

ATOM 2573 CB ILE A 344 -6.066 56.206 89.837 1.00 12.32 C

ATOM 2574 CGl ILE A 344 -6.695 57.475 90.437 1.00 11.67 C

ATOM 2575 CDl ILE A 344 -8.053 57.849 89.853 1.00 12.59 C W2025-7029WO / AM102903-PCT

ATOM 2576 CG2 ILE A 344 6.794 54.952 90.345 1.00 12.40 C

ATOM 2577 C ILE A 344 3.952 54.770 89.907 1.00 12.01 C

ATOM 2578 O ILE A 344 3.712 53.995 90.841 1.00 11.90 O

ATOM 2579 N LYS A 345 3.674 54.485 88.638 1.00 11.72 N

ATOM 2580 CA LYS A 345 3.068 53.217 88.241 1.00 11.98 C

ATOM 2581 CB LYS A 345 3.055 53.088 86.725 1.00 11.97 C

ATOM 2582 CG LYS A 345 4.419 52.835 86.109 1.00 12.63 C

ATOM 2583 CD LYS A 345 4.366 53.131 84.624 1.00 13.24 C

ATOM 2584 CE LYS A 345 5.569 52.594 83.902 1.00 13.11 C

ATOM 2585 NZ LYS A 345 5.342 52.682 82.443 1.00 11.37 N

ATOM 2586 C LYS A 345 1.654 53.043 88.785 1.00 12.01 C

ATOM 2587 O LYS A 345 1.275 51.942 89.191 1.00 12.15 O

ATOM 2588 N ALA A 346 0.877 54.126 88.785 1.00 11.77 N

ATOM 2589 CA ALA A 346 0.467 54.100 89.357 1.00 12.02 C

ATOM 2590 CB ALA A 346 1.163 55.438 89.153 1.00 12.14 C

ATOM 2591 C ALA A 346 0.436 53.720 90.837 1.00 12.13 C

ATOM 2592 O ALA A 346 1.217 52.876 91.280 1.00 11.89 O

ATOM 2593 N GLN A 347 0.481 54.319 91.596 1.00 12.35 N

ATOM 2594 CA GLN A 347 0.611 53.987 93.020 1.00 12.88 C

ATOM 2595 CB GLN A 347 1.614 54.911 93.723 1.00 13.32 C

ATOM 2596 CG GLN A 347 1.333 56.411 93.564 1.00 15.21 C

ATOM 2597 CD GLN A 347 0.101 56.812 93.917 1.00 18.16 C

ATOM 2598 OEl GLN A 347 0.649 56.389 94.934 1.00 19.66 O

ATOM 2599 NE2 GLN A 347 0.700 57.649 93.077 1.00 19.01 N

ATOM 2600 C GLN A 347 0.992 52.518 93.213 1.00 12.44 C

ATOM 2601 O GLN A 347 0.430 51.833 94.068 1.00 12.35 O

ATOM 2602 N TRP A 348 1.932 52.043 92.397 1.00 11.91 N

ATOM 2603 CA TRP A 348 2.361 50.645 92.415 1.00 11.98 C

ATOM 2604 CB TRP A 348 3.511 50.435 91.415 1.00 11.89 C

ATOM 2605 CG TRP A 348 3.862 49.005 91.158 1.00 11.82 C

ATOM 2606 CDl TRP A 348 4.758 48.242 91.849 1.00 11.60 C

ATOM 2607 NEl TRP A 348 4.809 46.975 91.318 1.00 11.39 N

ATOM 2608 CE2 TRP A 348 3.944 46.901 90.258 1.00 11.32 C

ATOM 2609 CD2 TRP A 348 3.332 48.164 90.123 1.00 11.73 C

ATOM 2610 CE3 TRP A 348 2.395 48.356 89.099 1.00 11.56 C

ATOM 2611 CZ3 TRP A 348 2.101 47.287 88.254 1.00 12.12 C

ATOM 2612 CH2 TRP A 348 2.730 46.046 88.414 1.00 12.11 C

ATOM 2613 CZ2 TRP A 348 3.649 45.829 89.409 1.00 12.36 C

ATOM 2614 C TRP A 348 1.182 49.716 92.118 1.00 12.06 C

ATOM 2615 O TRP A 348 0.998 48.701 92.785 1.00 11.88 O

ATOM 2616 N LEU A 349 0.385 50.087 91.117 1.00 12.23 N

ATOM 2617 CA LEU A 349 0.776 49.311 90.695 1.00 12.56 C

ATOM 2618 CB LEU A 349 1.455 50.034 89.526 1.00 12.46 C

ATOM 2619 CG LEU A 349 2.663 49.471 88.788 1.00 13.15 C

ATOM 2620 CDl LEU A 349 2.762 50.193 87.456 1.00 13.80 C

ATOM 2621 CD2 LEU A 349 3.962 49.620 89.583 1.00 12.71 C

ATOM 2622 C LEU A 349 1.759 49.112 91.850 1.00 12.54 C

ATOM 2623 O LEU A 349 2.244 47.996 92.083 1.00 12.55 O

ATOM 2624 N LYS A 350 2.042 50.196 92.566 1.00 12.86 N

ATOM 2625 CA LYS A 350 2.958 50.151 93.706 1.00 13.05 C

ATOM 2626 CB LYS A 350 3.259 51.555 94.225 1.00 13.18 C

ATOM 2627 CG LYS A 350 3.973 52.439 93.201 1.00 13.02 C

ATOM 2628 CD LYS A 350 4.444 53.748 93.809 1.00 14.30 C

ATOM 2629 CE LYS A 350 3.290 54.693 94.087 1.00 15.31 C

ATOM 2630 NZ LYS A 350 3.786 55.994 94.625 1.00 15.01 N

ATOM 2631 C LYS A 350 2.421 49.253 94.821 1.00 13.26 C

ATOM 2632 O LYS A 350 3.158 48.415 95.352 1.00 12.97 O

ATOM 2633 N HIS A 351 1.140 49.417 95.153 1.00 13.54 N

ATOM 2634 CA HIS A 351 0.468 48.551 96.132 1.00 14.23 C

ATOM 2635 CB HIS A 351 1.019 48.904 96.248 1.00 14.63 C

ATOM 2636 CG HIS A 351 1.296 50.097 97.110 1.00 16.78 C

ATOM 2637 NDl HIS A 351 2.388 50.916 96.916 1.00 18.98 N

ATOM 2638 CEl HIS A 351 2.377 51.882 97.818 1.00 19.83 C W2025-7029WO / AM102903-PCT

ATOM 2639 NE2 HIS A 351 1.314 51.724 98.586 1.00 19.68 N

ATOM 2640 CD2 HIS A 351 0.620 50.615 98.163 1.00 19.28 C

ATOM 2641 C HIS A 351 0.613 47.067 95.800 1.00 13.88 C

ATOM 2642 O HIS A 351 0.725 46.231 96.694 1.00 13.71 O

ATOM 2643 N ASN A 352 0.618 46.755 94.506 1.00 13.46 N

ATOM 2644 CA ASN A 352 0.698 45.380 94.039 1.00 13.35 C

ATOM 2645 CB ASN A 352 0.209 45.183 92.830 1.00 13.50 C

ATOM 2646 CG ASN A 352 1.660 45.096 93.221 1.00 14.11 C

ATOM 2647 ODl ASN A 352 2.177 44.006 93.461 1.00 16.61 O

ATOM 2648 ND2 ASN A 352 2.320 46.245 93.325 1.00 14.05 N

ATOM 2649 C ASN A 352 2.114 44.904 93.754 1.00 12.85 C

ATOM 2650 O ASN A 352 2.321 43.746 93.383 1.00 13.16 O

ATOM 2651 N LYS A 353 3.073 45.809 93.945 1.00 12.55 N

ATOM 2652 CA LYS A 353 4.506 45.498 93.907 1.00 12.41 C

ATOM 2653 CB LYS A 353 4.898 44.621 95.114 1.00 12.42 C

ATOM 2654 CG LYS A 353 4.541 45.284 96.458 1.00 13.52 C

ATOM 2655 CD LYS A 353 4.643 44.338 97.647 1.00 16.92 C

ATOM 2656 CE LYS A 353 4.194 45.060 98.921 1.00 19.04 C

ATOM 2657 NZ LYS A 353 4.569 44.337 100.177 1.00 20.53 N

ATOM 2658 C LYS A 353 4.972 44.918 92.562 1.00 11.73 C

ATOM 2659 O LYS A 353 5.837 44.039 92.509 1.00 11.74 O

ATOM 2660 N PHE A 354 4.398 45.433 91.472 1.00 11.24 N

ATOM 2661 CA PHE A 354 4.853 45.058 90.133 1.00 10.49 C

ATOM 2662 CB PHE A 354 3.784 45.358 89.070 1.00 10.27 C

ATOM 2663 CG PHE A 354 2.537 44.513 89.210 1.00 9.84 C

ATOM 2664 CDl PHE A 354 1.289 45.112 89.380 1.00 10.50 C

ATOM 2665 CEl PHE A 354 0.135 44.338 89.514 1.00 10.68 C

ATOM 2666 CZ PHE A 354 0.227 42.948 89.500 1.00 9.85 C

ATOM 2667 CE2 PHE A 354 1.466 42.334 89.339 1.00 9.74 C

ATOM 2668 CD2 PHE A 354 2.615 43.118 89.195 1.00 10.11 C

ATOM 2669 C PHE A 354 6.184 45.728 89.799 1.00 10.12 C

ATOM 2670 O PHE A 354 6.639 46.620 90.527 1.00 10.22 O

ATOM 2671 N GLY A 355 6.800 45.298 88.703 1.00 9.53 N

ATOM 2672 CA GLY A 355 8.123 45.785 88.317 1.00 9.25 C

ATOM 2673 C GLY A 355 8.172 47.216 87.820 1.00 8.89 C

ATOM 2674 O GLY A 355 9.239 47.836 87.810 1.00 9.06 O

ATOM 2675 N GLY A 356 7.023 47.730 87.387 1.00 8.43 N

ATOM 2676 CA GLY A 356 6.926 49.086 86.865 1.00 8.22 C

ATOM 2677 C GLY A 356 5.884 49.219 85.780 1.00 7.94 C

ATOM 2678 O GLY A 356 4.927 48.427 85.712 1.00 7.37 O

ATOM 2679 N ALA A 357 6.082 50.224 84.930 1.00 7.69 N

ATOM 2680 CA ALA A 357 5.128 50.567 83.888 1.00 7.55 C

ATOM 2681 CB ALA A 357 4.466 51.905 84.213 1.00 7.49 C

ATOM 2682 C ALA A 357 5.811 50.645 82.532 1.00 7.87 C

ATOM 2683 O ALA A 357 6.992 51.009 82.442 1.00 7.48 O

ATOM 2684 N MET A 358 5.073 50.279 81.486 1.00 7.64 N

ATOM 2685 CA MET A 358 5.483 50.571 80.110 1.00 8.06 C

ATOM 2686 CB MET A 358 5.834 49.311 79.298 1.00 8.08 C

ATOM 2687 CG MET A 358 4.698 48.326 79.044 1.00 8.76 C

ATOM 2688 SD MET A 358 3.676 48.760 77.621 1.00 9.21 S

ATOM 2689 CE MET A 358 2.836 47.196 77.346 1.00 9.71 C

ATOM 2690 C MET A 358 4.413 51.423 79.447 1.00 7.68 C

ATOM 2691 O MET A 358 3.247 51.392 79.853 1.00 7.62 O

ATOM 2692 N VAL A 359 4.825 52.194 78.447 1.00 7.76 N

ATOM 2693 CA VAL A 359 3.961 53.193 77.840 1.00 7.80 C

ATOM 2694 CB VAL A 359 4.385 54.644 78.233 1.00 7.95 C

ATOM 2695 CGl VAL A 359 3.432 55.658 77.635 1.00 8.01 C

ATOM 2696 CG2 VAL A 359 4.418 54.811 79.742 1.00 7.71 C

ATOM 2697 C VAL A 359 3.961 53.049 76.327 1.00 8.20 C

ATOM 2698 O VAL A 359 5.015 53.084 75.692 1.00 8.27 O

ATOM 2699 N TRP A 360 2.770 52.863 75.765 1.00 8.15 N

ATOM 2700 CA TRP A 360 2.582 52.923 74.330 1.00 8.23 C

ATOM 2701 CB TRP A 360 1.892 51.655 73.797 1.00 8.54 C W2025-7029WO / AM102903-PCT

ATOM 2702 CG TRP A 360 1.862 51.664 72.305 1.00 7.82 C

ATOM 2703 CDl TRP A 360 0.961 52.306 71.497 1.00 8.11 C

ATOM 2704 NEl TRP A 360 1.288 52.113 70.175 1.00 7.57 N

ATOM 2705 CE2 TRP A 360 2.422 51.349 70.109 1.00 6.99 C

ATOM 2706 CD2 TRP A 360 2.816 51.055 71.435 1.00 6.60 C

ATOM 2707 CE3 TRP A 360 3.954 50.268 71.645 1.00 6.92 C

ATOM 2708 CZ3 TRP A 360 4.662 49.809 70.538 1.00 6.93 C

ATOM 2709 CH2 TRP A 360 4.243 50.117 69.231 1.00 6.79 C

ATOM 2710 CZ2 TRP A 360 3.132 50.887 68.996 1.00 6.54 C

ATOM 2711 C TRP A 360 1.722 54.149 74.020 1.00 8.38 C

ATOM 2712 O TRP A 360 0.543 54.149 74.356 1.00 8.39 O

ATOM 2713 N ALA A 361 2.278 55.193 73.401 1.00 8.47 N

ATOM 2714 CA ALA A 361 3.699 55.321 73.050 1.00 8.69 C

ATOM 2715 CB ALA A 361 3.911 55.036 71.559 1.00 8.42 C

ATOM 2716 C ALA A 361 4.173 56.736 73.381 1.00 8.71 C

ATOM 2717 O ALA A 361 3.360 57.649 73.528 1.00 8.62 O

ATOM 2718 N ILE A 362 5.487 56.925 73.476 1.00 8.81 N

ATOM 2719 CA ILE A 362 6.046 58.238 73.822 1.00 9.64 C

ATOM 2720 CB ILE A 362 7.601 58.178 73.970 1.00 9.65 C

ATOM 2721 CGl ILE A 362 8.145 59.437 74.659 1.00 10.28 C

ATOM 2722 CDl ILE A 362 9.485 59.230 75.354 1.00 11.08 C

ATOM 2723 CG2 ILE A 362 8.297 57.911 72.624 1.00 10.59 C

ATOM 2724 C ILE A 362 5.585 59.335 72.842 1.00 9.34 C

ATOM 2725 O ILE A 362 5.299 60.470 73.236 1.00 10.31 O

ATOM 2726 N ASP A 363 5.477 58.971 71.571 1.00 9.39 N

ATOM 2727 CA ASP A 363 5.117 59.925 70.525 1.00 9.28 C

ATOM 2728 CB ASP A 363 5.612 59.421 69.165 1.00 9.38 C

ATOM 2729 CG ASP A 363 5.116 58.027 68.847 1.00 9.28 C

ATOM 2730 ODl ASP A 363 3.906 57.876 68.621 1.00 9.09 O

ATOM 2731 OD2 ASP A 363 5.935 57.083 68.828 1.00 10.97 O

ATOM 2732 C ASP A 363 3.616 60.273 70.486 1.00 9.55 C

ATOM 2733 O ASP A 363 3.202 61.141 69.719 1.00 9.78 O

ATOM 2734 N LEU A 364 2.816 59.592 71.309 1.00 9.09 N

ATOM 2735 CA LEU A 364 1.369 59.852 71.391 1.00 9.20 C

ATOM 2736 CB LEU A 364 0.573 58.542 71.354 1.00 9.39 C

ATOM 2737 CG LEU A 364 0.752 57.656 70.105 1.00 8.70 C

ATOM 2738 CDl LEU A 364 0.109 56.294 70.315 1.00 7.74 C

ATOM 2739 CD2 LEU A 364 0.190 58.321 68.846 1.00 10.04 C

ATOM 2740 C LEU A 364 0.980 60.708 72.612 1.00 9.27 C

ATOM 2741 O LEU A 364 0.130 61.254 72.673 1.00 9.26 O

ATOM 2742 N ASP A 365 1.900 60.817 73.570 1.00 9.38 N

ATOM 2743 CA ASP A 365 1.777 61.762 74.687 1.00 9.64 C

ATOM 2744 CB ASP A 365 2.885 61.492 75.714 1.00 9.58 C

ATOM 2745 CG ASP A 365 2.564 62.031 77.109 1.00 9.82 C

ATOM 2746 ODl ASP A 365 1.537 62.709 77.303 1.00 8.73 O

ATOM 2747 OD2 ASP A 365 3.365 61.765 78.026 1.00 9.42 O

ATOM 2748 C ASP A 365 1.891 63.198 74.148 1.00 9.88 C

ATOM 2749 O ASP A 365 2.389 63.409 73.032 1.00 9.87 O

ATOM 2750 N ASP A 366 1.432 64.181 74.925 1.00 10.03 N

ATOM 2751 CA ASP A 366 1.531 65.579 74.501 1.00 10.42 C

ATOM 2752 CB ASP A 366 0.522 66.464 75.253 1.00 10.76 C

ATOM 2753 CG ASP A 366 0.454 67.892 74.699 1.00 11.24 C

ATOM 2754 ODl ASP A 366 0.882 68.124 73.546 1.00 11.13 O

ATOM 2755 OD2 ASP A 366 0.033 68.785 75.427 1.00 11.23 O

ATOM 2756 C ASP A 366 2.968 66.069 74.694 1.00 10.52 C

ATOM 2757 O ASP A 366 3.270 66.819 75.628 1.00 10.28 O

ATOM 2758 N PHE A 367 3.852 65.629 73.800 1.00 10.80 N

ATOM 2759 CA PHE A 367 5.283 65.914 73.918 1.00 11.48 C

ATOM 2760 CB PHE A 367 6.123 65.048 72.958 1.00 11.39 C

ATOM 2761 CG PHE A 367 5.803 65.231 71.500 1.00 11.61 C

ATOM 2762 CDl PHE A 367 4.764 64.522 70.904 1.00 11.98 C

ATOM 2763 CEl PHE A 367 4.480 64.675 69.551 1.00 11.36 C

ATOM 2764 CZ PHE A 367 5.251 65.533 68.776 1.00 11.69 C W2025-7029WO / AM102903-PCT

ATOM 2765 CE2 PHE A 367 6.296 66.234 69.353 1.00 12.11 C

ATOM 2766 CD2 PHE A 367 6.575 66.077 70.706 1.00 12.27 C

ATOM 2767 C PHE A 367 5.636 67.400 73.796 1.00 11.86 C

ATOM 2768 O PHE A 367 6.546 67.879 74.472 1.00 12.23 O

ATOM 2769 N THR A 368 4.909 68.129 72.951 1.00 12.55 N

ATOM 2770 CA THR A 368 5.134 69.576 72.807 1.00 13.25 C

ATOM 2771 CB THR A 368 4.507 70.151 71.516 1.00 13.26 C

ATOM 2772 OGl THR A 368 3.075 70.122 71.619 1.00 13.62 O

ATOM 2773 CG2 THR A 368 4.957 69.376 70.283 1.00 13.66 C

ATOM 2774 C THR A 368 4.558 70.358 73.990 1.00 13.68 C

ATOM 2775 O THR A 368 5.013 71.469 74.296 1.00 14.00 O

ATOM 2776 N GLY A 369 3.538 69.788 74.629 1.00 14.05 N

ATOM 2777 CA GLY A 369 2.839 70.448 75.732 1.00 14.32 C

ATOM 2778 C GLY A 369 1.803 71.460 75.270 1.00 14.48 C

ATOM 2779 O GLY A 369 1.146 72.098 76.096 1.00 14.65 O

ATOM 2780 N THR A 370 1.639 71.591 73.952 1.00 14.58 N

ATOM 2781 CA THR A 370 0.809 72.655 73.373 1.00 14.91 C

ATOM 2782 CB THR A 370 1.338 73.123 71.984 1.00 15.01 C

ATOM 2783 OGl THR A 370 1.207 72.064 71.024 1.00 15.68 O

ATOM 2784 CG2 THR A 370 2.797 73.567 72.077 1.00 14.83 C

ATOM 2785 C THR A 370 0.675 72.298 73.252 1.00 14.81 C

ATOM 2786 O THR A 370 1.522 73.185 73.108 1.00 15.05 O

ATOM 2787 N PHE A 371 0.989 71.007 73.313 1.00 14.55 N

ATOM 2788 CA PHE A 371 2.363 70.548 73.137 1.00 14.31 C

ATOM 2789 CB PHE A 371 2.381 69.170 72.469 1.00 14.18 C

ATOM 2790 CG PHE A 371 1.938 69.189 71.037 1.00 13.69 C

ATOM 2791 CDl PHE A 371 0.583 69.233 70.710 1.00 13.45 C

ATOM 2792 CEl PHE A 371 0.169 69.252 69.380 1.00 13.38 C

ATOM 2793 CZ PHE A 371 1.116 69.222 68.358 1.00 13.88 C

ATOM 2794 CE2 PHE A 371 2.471 69.176 68.670 1.00 14.32 C

ATOM 2795 CD2 PHE A 371 2.875 69.160 70.010 1.00 13.62 C

ATOM 2796 C PHE A 371 3.161 70.503 74.431 1.00 14.27 C

ATOM 2797 O PHE A 371 4.341 70.871 74.448 1.00 14.38 O

ATOM 2798 N CYS A 372 2.515 70.051 75.504 1.00 14.27 N

ATOM 2799 CA CYS A 372 3.201 69.770 76.764 1.00 14.55 C

ATOM 2800 CB CYS A 372 2.796 68.388 77.287 1.00 14.50 C

ATOM 2801 SG CYS A 372 3.017 67.071 76.074 1.00 13.87

ATOM 2802 C CYS A 372 2.969 70.817 77.843 1.00 14.93 C

ATOM 2803 O CYS A 372 3.726 70.881 78.815 1.00 15.02 O

ATOM 2804 N ASN A 373 1.925 71.627 77.669 1.00 15.57 N

ATOM 2805 CA ASN A 373 1.528 72.649 78.654 1.00 16.29 C

ATOM 2806 CB ASN A 373 2.577 73.770 78.736 1.00 16.74 C

ATOM 2807 CG ASN A 373 3.011 74.268 77.366 1.00 18.50 C

ATOM 2808 ODl ASN A 373 2.182 74.631 76.527 1.00 21.42 O

ATOM 2809 ND2 ASN A 373 4.320 74.288 77.134 1.00 20.75 N

ATOM 2810 C ASN A 373 1.252 72.051 80.037 1.00 16.19 C

ATOM 2811 O ASN A 373 1.642 72.616 81.071 1.00 16.44 O

ATOM 2812 N GLN A 374 0.587 70.896 80.040 1.00 15.68 N

ATOM 2813 CA GLN A 374 0.263 70.178 81.271 1.00 15.68 C

ATOM 2814 CB GLN A 374 1.010 68.843 81.324 1.00 15.49 C

ATOM 2815 CG GLN A 374 2.519 68.955 81.363 1.00 15.67 C

ATOM 2816 CD GLN A 374 3.189 67.598 81.419 1.00 15.62 C

ATOM 2817 OEl GLN A 374 3.837 67.259 82.407 1.00 16.14 O

ATOM 2818 NE2 GLN A 374 3.011 66.803 80.370 1.00 14.32 N

ATOM 2819 C GLN A 374 1.237 69.929 81.402 1.00 15.51 C

ATOM 2820 O GLN A 374 1.668 69.094 82.206 1.00 15.86 O

ATOM 2821 N GLY A 375 2.023 70.658 80.617 1.00 15.19 N

ATOM 2822 CA GLY A 375 3.468 70.471 80.585 1.00 14.74 C

ATOM 2823 C GLY A 375 3.848 69.476 79.508 1.00 14.32 C

ATOM 2824 O GLY A 375 2.988 68.817 78.929 1.00 14.38 O

ATOM 2825 N LYS A 376 5.141 69.372 79.232 1.00 14.00 N

ATOM 2826 CA LYS A 376 5.619 68.435 78.217 1.00 13.47 C

ATOM 2827 CB LYS A 376 7.032 68.810 77.774 1.00 14.11 C W2025-7029WO / AM102903-PCT

ATOM 2828 CG LYS A 376 7.053 70.123 76.993 1.00 15.44 C

ATOM 2829 CD LYS A 376 8.452 70.566 76.657 1.00 19.68 C

ATOM 2830 CE LYS A 376 8.430 71.943 76.010 1.00 20.83 C

ATOM 2831 NZ LYS A 376 9.744 72.264 75.390 1.00 23.79 N

ATOM 2832 C LYS A 376 5.529 67.001 78.737 1.00 12.69 C

ATOM 2833 O LYS A 376 5.750 66.754 79.928 1.00 12.49 O

ATOM 2834 N PHE A 377 5.161 66.073 77.851 1.00 11.92 N

ATOM 2835 CA PHE A 377 4.947 64.662 78.218 1.00 11.35 C

ATOM 2836 CB PHE A 377 6.285 63.927 78.378 1.00 11.57 C

ATOM 2837 CG PHE A 377 7.135 63.899 77.133 1.00 11.54 C

ATOM 2838 CDl PHE A 377 6.899 62.961 76.131 1.00 12.75 C

ATOM 2839 CEl PHE A 377 7.702 62.918 74.985 1.00 13.23 C

ATOM 2840 CZ PHE A 377 8.755 63.816 74.844 1.00 11.97 C

ATOM 2841 CE2 PHE A 377 9.001 64.757 75.841 1.00 13.02 C

ATOM 2842 CD2 PHE A 377 8.195 64.787 76.982 1.00 12.30 C

ATOM 2843 C PHE A 377 4.137 64.511 79.519 1.00 11.08 C

ATOM 2844 O PHE A 377 4.622 63.898 80.470 1.00 10.96 O

ATOM 2845 N PRO A 378 2.905 65.058 79.564 1.00 10.92 N

ATOM 2846 CA PRO A 378 2.183 65.076 80.848 1.00 10.55 C

ATOM 2847 CB PRO A 378 0.889 65.830 80.520 1.00 10.78 C

ATOM 2848 CG PRO A 378 0.712 65.682 79.032 1.00 10.80 C

ATOM 2849 CD PRO A 378 2.114 65.671 78.479 1.00 10.92 C

ATOM 2850 C PRO A 378 1.874 63.686 81.396 1.00 10.36 C

ATOM 2851 O PRO A 378 2.010 63.459 82.602 1.00 10.36 O

ATOM 2852 N LEU A 379 1.486 62.757 80.518 1.00 9.91 N

ATOM 2853 CA LEU A 379 1.141 61.401 80.955 1.00 9.58 C

ATOM 2854 CB LEU A 379 0.417 60.622 79.849 1.00 9.66 C

ATOM 2855 CG LEU A 379 0.944 61.166 79.379 1.00 9.32 C

ATOM 2856 CDl LEU A 379 1.622 60.168 78.455 1.00 10.38 C

ATOM 2857 CD2 LEU A 379 1.859 61.486 80.552 1.00 10.96 C

ATOM 2858 C LEU A 379 2.358 60.633 81.479 1.00 9.64 C

ATOM 2859 O LEU A 379 2.310 60.055 82.562 1.00 9.07 O

ATOM 2860 N ILE A 380 3.456 60.651 80.727 1.00 9.61 N

ATOM 2861 CA ILE A 380 4.653 59.928 81.156 1.00 9.55 C

ATOM 2862 CB ILE A 380 5.661 59.714 80.006 1.00 9.68 C

ATOM 2863 CGl ILE A 380 4.973 58.959 78.858 1.00 8.80 C

ATOM 2864 CDl ILE A 380 5.755 58.952 77.532 1.00 8.93 C

ATOM 2865 CG2 ILE A 380 6.855 58.914 80.503 1.00 9.34 C

ATOM 2866 C ILE A 380 5.307 60.583 82.379 1.00 9.93 C

ATOM 2867 O ILE A 380 5.790 59.883 83.269 1.00 9.93 O

ATOM 2868 N SER A 381 5.279 61.918 82.427 1.00 10.29 N

ATOM 2869 CA SER A 381 5.771 62.679 83.583 1.00 10.74 C

ATOM 2870 CB SER A 381 5.694 64.191 83.329 1.00 11.06 C

ATOM 2871 OG SER A 381 6.514 64.591 82.233 1.00 12.37 O

ATOM 2872 C SER A 381 5.008 62.315 84.865 1.00 10.81 C

ATOM 2873 O SER A 381 5.597 62.265 85.946 1.00 10.86 O

ATOM 2874 N THR A 382 3.708 62.052 84.728 1.00 10.67 N

ATOM 2875 CA THR A 382 2.869 61.622 85.853 1.00 10.85 C

ATOM 2876 CB THR A 382 1.382 61.482 85.425 1.00 10.89 C

ATOM 2877 OGl THR A 382 0.907 62.748 84.952 1.00 11.37 O

ATOM 2878 CG2 THR A 382 0.503 61.029 86.594 1.00 11.01 C

ATOM 2879 C THR A 382 3.405 60.309 86.432 1.00 10.92 C

ATOM 2880 O THR A 382 3.478 60.138 87.656 1.00 10.99 O

ATOM 2881 N LEU A 383 3.807 59.400 85.543 1.00 10.52 N

ATOM 2882 CA LEU A 383 4.369 58.115 85.952 1.00 10.77 C

ATOM 2883 CB LEU A 383 4.395 57.125 84.779 1.00 10.80 C

ATOM 2884 CG LEU A 383 3.018 56.744 84.220 1.00 11.03 C

ATOM 2885 CDl LEU A 383 3.148 55.706 83.115 1.00 11.09 C

ATOM 2886 CD2 LEU A 383 2.081 56.247 85.326 1.00 12.57 C

ATOM 2887 C LEU A 383 5.757 58.256 86.561 1.00 10.72 C

ATOM 2888 O LEU A 383 6.059 57.612 87.563 1.00 10.64 O

ATOM 2889 N LYS A 384 6.597 59.089 85.947 1.00 10.87 N

ATOM 2890 CA LYS A 384 7.944 59.337 86.455 1.00 11.64 C W2025-7029WO / AM102903-PCT

ATOM 2891 CB LYS A 384 8.668 60.364 85.580 1.00 11.36 C

ATOM 2892 CG LYS A 384 10.069 60.727 86.055 1.00 12.76 C

ATOM 2893 CD LYS A 384 10.734 61.686 85.084 1.00 13.21 C

ATOM 2894 CE LYS A 384 12.063 62.202 85.622 1.00 13.87 C

ATOM 2895 NZ LYS A 384 13.077 61.123 85.739 1.00 14.50 N

ATOM 2896 C LYS A 384 7.875 59.806 87.908 1.00 11.78 C

ATOM 2897 O LYS A 384 8.624 59.319 88.759 1.00 11.99 O

ATOM 2898 N LYS A 385 6.962 60.734 88.185 1.00 12.13 N

ATOM 2899 CA LYS A 385 6.771 61.247 89.542 1.00 12.98 C

ATOM 2900 CB LYS A 385 5.848 62.474 89.542 1.00 13.12 C

ATOM 2901 CG LYS A 385 5.725 63.144 90.905 1.00 15.46 C

ATOM 2902 CD LYS A 385 4.753 64.314 90.886 1.00 18.37 C

ATOM 2903 CE LYS A 385 4.637 64.930 92.275 1.00 20.94 C

ATOM 2904 NZ LYS A 385 3.928 66.241 92.248 1.00 23.26 N

ATOM 2905 C LYS A 385 6.243 60.176 90.496 1.00 12.81 C

ATOM 2906 O LYS A 385 6.804 59.966 91.574 1.00 12.61 O

ATOM 2907 N ALA A 386 5.173 59.497 90.090 1.00 12.53 N

ATOM 2908 CA ALA A 386 4.488 58.548 90.969 1.00 12.86 C

ATOM 2909 CB ALA A 386 3.170 58.120 90.356 1.00 12.53 C

ATOM 2910 C ALA A 386 5.350 57.332 91.302 1.00 13.11 C

ATOM 2911 O ALA A 386 5.248 56.767 92.397 1.00 13.12 O

ATOM 2912 N LEU A 387 6.207 56.942 90.363 1.00 13.49 N

ATOM 2913 CA LEU A 387 7.054 55.759 90.541 1.00 14.59 C

ATOM 2914 CB LEU A 387 7.229 55.019 89.208 1.00 14.52 C

ATOM 2915 CG LEU A 387 5.958 54.467 88.547 1.00 14.37 C

ATOM 2916 CDl LEU A 387 6.257 53.950 87.145 1.00 14.79 C

ATOM 2917 CD2 LEU A 387 5.296 53.383 89.400 1.00 14.60 C

ATOM 2918 C LEU A 387 8.413 56.072 91.179 1.00 15.40 C

ATOM 2919 O LEU A 387 9.314 55.230 91.177 1.00 15.13 O

ATOM 2920 N GLY A 388 8.552 57.282 91.720 1.00 16.50 N

ATOM 2921 CA GLY A 388 9.740 57.664 92.485 1.00 18.00 C

ATOM 2922 C GLY A 388 10.989 57.884 91.655 1.00 19.13 C

ATOM 2923 O GLY A 388 12.108 57.676 92.139 1.00 18.97 O

ATOM 2924 N LEU A 389 10.800 58.320 90.410 1.00 20.12 N

ATOM 2925 CA LEU A 389 11.915 58.536 89.488 1.00 21.71 C

ATOM 2926 CB LEU A 389 11.682 57.772 88.174 1.00 21.43 C

ATOM 2927 CG LEU A 389 11.595 56.243 88.253 1.00 21.29 C

ATOM 2928 CDl LEU A 389 10.815 55.688 87.077 1.00 21.41 C

ATOM 2929 CD2 LEU A 389 12.981 55.607 88.338 1.00 21.31 C

ATOM 2930 C LEU A 389 12.226 60.014 89.193 1.00 22.87 C

ATOM 2931 O LEU A 389 13.094 60.304 88.368 1.00 23.00 O

ATOM 2932 N GLN A 390 11.534 60.947 89.848 1.00 24.43 N

ATOM 2933 CA GLN A 390 11.787 62.377 89.590 1.00 26.21 C

ATOM 2934 CB GLN A 390 10.803 63.286 90.338 1.00 26.46 C

ATOM 2935 CG GLN A 390 9.441 63.453 89.657 1.00 28.25 C

ATOM 2936 CD GLN A 390 9.515 64.002 88.229 1.00 30.52 C

ATOM 2937 OEl GLN A 390 10.440 64.738 87.871 1.00 32.11 O

ATOM 2938 NE2 GLN A 390 8.524 63.651 87.412 1.00 32.00 N

ATOM 2939 C GLN A 390 13.227 62.794 89.898 1.00 26.96 C

ATOM 2940 O GLN A 390 13.801 63.625 89.193 1.00 27.16 O

ATOM 2941 N SER A 391 13.799 62.205 90.945 1.00 27.93 N

ATOM 2942 CA SER A 391 15.170 62.499 91.357 1.00 29.01 C

ATOM 2943 CB SER A 391 15.284 62.433 92.884 1.00 29.02 C

ATOM 2944 OG SER A 391 15.015 61.121 93.356 1.00 30.16 O

ATOM 2945 C SER A 391 16.194 61.560 90.710 1.00 29.43 C

ATOM 2946 O SER A 391 17.382 61.598 91.058 1.00 29.68 O

ATOM 2947 N ALA A 392 15.735 60.724 89.774 1.00 29.90 N

ATOM 2948 CA ALA A 392 16.610 59.760 89.100 1.00 30.23 C

ATOM 2949 CB ALA A 392 15.835 58.930 88.088 1.00 30.32 C

ATOM 2950 C ALA A 392 17.783 60.460 88.427 1.00 30.47 C

ATOM 2951 O ALA A 392 17.631 61.556 87.874 1.00 30.47 O

ATOM 2952 N SER A 393 18.945 59.814 88.496 1.00 30.73 N

ATOM 2953 CA SER A 393 20.193 60.342 87.954 1.00 30.93 C W2025-7029WO / AM102903-PCT

ATOM 2954 CB SER A 393 21.337 59.359 88.225 1.00 31.02 C

ATOM 2955 OG SER A 393 22.460 59.630 87.403 1.00 31.80 O

ATOM 2956 C SER A 393 20.086 60.613 86.461 1.00 30.97 C

ATOM 2957 O SER A 393 19.663 59.743 85.687 1.00 31.02 O

ATOM 2958 N CYS A 394 20.460 61.823 86.055 1.00 30.82 N

ATOM 2959 CA CYS A 394 20.502 62.126 84.635 1.00 30.86 C

ATOM 2960 CB CYS A 394 19.203 62.749 84.155 1.00 30.65 C

ATOM 2961 SG CYS A 394 18.756 62.005 82.609 1.00 31.25

ATOM 2962 C CYS A 394 21.717 62.923 84.196 1.00 30.79 C

ATOM 2963 O CYS A 394 21.710 64.155 84.187 1.00 30.94 O

ATOM 2964 N THR A 395 22.752 62.186 83.815 1.00 30.73 N

ATOM 2965 CA THR A 395 24.043 62.746 83.466 1.00 30.55 C

ATOM 2966 CB THR A 395 25.011 62.668 84.677 1.00 30.60 C

ATOM 2967 OGl THR A 395 24.479 63.434 85.767 1.00 30.86 O

ATOM 2968 CG2 THR A 395 26.393 63.193 84.326 1.00 30.33 C

ATOM 2969 C THR A 395 24.607 61.941 82.306 1.00 30.45 C

ATOM 2970 O THR A 395 24.423 60.720 82.244 1.00 30.27 O

ATOM 2971 N ALA A 396 25.282 62.628 81.385 1.00 30.25 N

ATOM 2972 CA ALA A 396 26.022 61.966 80.313 1.00 30.16 C

ATOM 2973 CB ALA A 396 26.753 63.002 79.462 1.00 30.07 C

ATOM 2974 C ALA A 396 27.013 60.947 80.898 1.00 30.07 C

ATOM 2975 O ALA A 396 27.522 61.145 82.007 1.00 29.89 O

ATOM 2976 N PRO A 397 27.268 59.837 80.174 1.00 30.04 N

ATOM 2977 CA PRO A 397 28.278 58.876 80.632 1.00 30.12 C

ATOM 2978 CB PRO A 397 28.083 57.685 79.686 1.00 30.09 C

ATOM 2979 CG PRO A 397 27.506 58.275 78.452 1.00 30.00 C

ATOM 2980 CD PRO A 397 26.623 59.395 78.925 1.00 30.05 C

ATOM 2981 C PRO A 397 29.706 59.421 80.527 1.00 30.15 C

ATOM 2982 O PRO A 397 29.941 60.413 79.832 1.00 30.20 O

ATOM 2983 N ALA A 398 30.639 58.766 81.218 1.00 30.35 N

ATOM 2984 CA ALA A 398 32.050 59.153 81.216 1.00 30.51 C

ATOM 2985 CB ALA A 398 32.827 58.324 82.236 1.00 30.55 C

ATOM 2986 C ALA A 398 32.682 59.020 79.831 1.00 30.63 C

ATOM 2987 O ALA A 398 33.476 59.869 79.420 1.00 30.68 O

ATOM 2988 N TYR B 22 11.028 46.425 25.113 1.00 12.95 N

ATOM 2989 CA TYR B 22 10.161 46.241 26.320 1.00 13.14 C

ATOM 2990 CB TYR B 22 -8.781 46.898 26.115 1.00 13.02 C

ATOM 2991 CG TYR B 22 -8.047 46.338 24.919 1.00 12.49 C

ATOM 2992 CDl TYR B 22 -8.028 47.023 23.701 1.00 12.97 C

ATOM 2993 CEl TYR B 22 -7.378 46.493 22.592 1.00 11.82 C

ATOM 2994 CZ TYR B 22 -6.743 45.264 22.693 1.00 12.15 C

ATOM 2995 OH TYR B 22 -6.104 44.725 21.600 1.00 12.76 O

ATOM 2996 CE2 TYR B 22 -6.757 44.563 23.891 1.00 11.99 C

ATOM 2997 CD2 TYR B 22 -7.406 45.104 24.992 1.00 11.99 C

ATOM 2998 C TYR B 22 10.848 46.812 27.549 1.00 13.55 C

ATOM 2999 O TYR B 22 11.696 47.705 27.433 1.00 14.20 O

ATOM 3000 N GLN B 23 10.489 46.276 28.714 1.00 13.60 N

ATOM 3001 CA GLN B 23 10.901 46.844 29.990 1.00 13.61 C

ATOM 3002 CB GLN B 23 11.184 45.750 31.039 1.00 14.32 C

ATOM 3003 CG GLN B 23 12.207 44.666 30.639 1.00 17.03 C

ATOM 3004 CD GLN B 23 13.606 45.209 30.353 1.00 20.00 C

ATOM 3005 OEl GLN B 23 13.902 46.385 30.589 1.00 22.01 O

ATOM 3006 NE2 GLN B 23 14.476 44.343 29.843 1.00 21.81 N

ATOM 3007 C GLN B 23 -9.779 47.741 30.492 1.00 12.80 C

ATOM 3008 O GLN B 23 -8.600 47.501 30.198 1.00 12.44 O

ATOM 3009 N LEU B 24 10.155 48.779 31.228 1.00 11.86 N

ATOM 3010 CA LEU B 24 -9.204 49.576 31.990 1.00 11.44 C

ATOM 3011 CB LEU B 24 -9.039 50.979 31.399 1.00 11.33 C

ATOM 3012 CG LEU B 24 -8.086 51.959 32.106 1.00 11.30 C

ATOM 3013 CDl LEU B 24 -6.695 51.354 32.360 1.00 11.73 C

ATOM 3014 CD2 LEU B 24 -7.986 53.256 31.309 1.00 11.78 C

ATOM 3015 C LEU B 24 -9.701 49.635 33.423 1.00 11.36 C

ATOM 3016 O LEU B 24 10.686 50.319 33.731 1.00 11.01 O W2025-7029WO / AM102903-PCT

ATOM 3017 N THR B 25 -9.006 48.904 34.286 1.00 10.97 N

ATOM 3018 CA THR B 25 -9.427 48.707 35.662 1.00 11.14 C

ATOM 3019 CB THR B 25 -9.429 47.201 35.999 1.00 11.07 C

ATOM 3020 OGl THR B 25 10.391 46.540 35.166 1.00 11.25 O

ATOM 3021 CG2 THR B 25 -9.774 46.951 37.463 1.00 10.98 C

ATOM 3022 C THR B 25 -8.501 49.490 36.586 1.00 11.16 C

ATOM 3023 O THR B 25 -7.281 49.360 36.507 1.00 11.67 O

ATOM 3024 N CYS B 26 -9.093 50.310 37.449 1.00 10.75 N

ATOM 3025 CA CYS B 26 -8.332 51.226 38.291 1.00 10.83 C

ATOM 3026 CB CYS B 26 -8.640 52.669 37.889 1.00 11.03 C

ATOM 3027 SG CYS B 26 -8.319 52.970 36.131 1.00 12.70 S

ATOM 3028 C CYS B 26 -8.632 51.010 39.759 1.00 10.25 C

ATOM 3029 O CYS B 26 -9.797 51.001 40.162 1.00 10.67 O

ATOM 3030 N TYR B 27 -7.578 50.827 40.553 1.00 9.57 N

ATOM 3031 CA TYR B 27 -7.734 50.614 41.989 1.00 9.07 C

ATOM 3032 CB TYR B 27 -6.637 49.697 42.527 1.00 8.58 C

ATOM 3033 CG TYR B 27 -6.806 48.237 42.183 1.00 7.99 C

ATOM 3034 CDl TYR B 27 -7.426 47.364 43.077 1.00 8.65 C

ATOM 3035 CEl TYR B 27 -7.576 46.013 42.779 1.00 7.63 C

ATOM 3036 CZ TYR B 27 -7.102 45.522 41.567 1.00 8.09 C

ATOM 3037 OH TYR B 27 -7.253 44.188 41.273 1.00 8.42 O

ATOM 3038 CE2 TYR B 27 -6.482 46.370 40.660 1.00 7.37 C

ATOM 3039 CD2 TYR B 27 -6.330 47.720 40.977 1.00 7.14 C

ATOM 3040 C TYR B 27 -7.704 51.922 42.757 1.00 9.13 C

ATOM 3041 O TYR B 27 -6.825 52.763 42.536 1.00 9.05 O

ATOM 3042 N PHE B 28 -8.671 52.076 43.658 1.00 8.98 N

ATOM 3043 CA PHE B 28 -8.710 53.185 44.607 1.00 9.21 C

ATOM 3044 CB PHE B 28 10.115 53.801 44.651 1.00 9.44 C

ATOM 3045 CG PHE B 28 10.369 54.665 45.857 1.00 9.45 C

ATOM 3046 CDl PHE B 28 -9.917 55.981 45.903 1.00 10.45 C

ATOM 3047 CEl PHE B 28 10.151 56.775 47.032 1.00 10.73 C

ATOM 3048 CZ PHE B 28 10.844 56.250 48.119 1.00 9.86 C

ATOM 3049 CE2 PHE B 28 11.301 54.942 48.080 1.00 9.28 C

ATOM 3050 CD2 PHE B 28 11.068 54.158 46.954 1.00 9.89 C

ATOM 3051 C PHE B 28 -8.310 52.669 45.990 1.00 9.03 C

ATOM 3052 O PHE B 28 -8.723 51.578 46.396 1.00 9.47 O

ATOM 3053 N THR B 29 -7.529 53.461 46.721 1.00 8.94 N

ATOM 3054 CA THR B 29 -7.079 53.042 48.056 1.00 8.60 C

ATOM 3055 CB THR B 29 -5.536 52.994 48.179 1.00 8.74 C

ATOM 3056 OGl THR B 29 -4.992 54.326 48.188 1.00 8.67 O

ATOM 3057 CG2 THR B 29 -4.920 52.183 47.039 1.00 8.07 C

ATOM 3058 C THR B 29 -7.685 53.898 49.163 1.00 8.84 C

ATOM 3059 O THR B 29 -7.690 55.131 49.074 1.00 8.48 O

ATOM 3060 N ASN B 30 -8.203 53.242 50.204 1.00 9.08 N

ATOM 3061 CA ASN B 30 -8.890 53.963 51.284 1.00 9.20 C

ATOM 3062 CB ASN B 30 10.000 53.105 51.925 1.00 9.36 C

ATOM 3063 CG ASN B 30 -9.472 51.888 52.683 1.00 9.79 C

ATOM 3064 ODl ASN B 30 -8.285 51.573 52.647 1.00 9.46 O

ATOM 3065 ND2 ASN B 30 10.378 51.194 53.374 1.00 9.31 N

ATOM 3066 C ASN B 30 -7.976 54.633 52.329 1.00 9.45 C

ATOM 3067 O ASN B 30 -8.458 55.201 53.311 1.00 9.72 O

ATOM 3068 N TRP B 31 -6.664 54.578 52.102 1.00 9.60 N

ATOM 3069 CA TRP B 31 -5.709 55.307 52.945 1.00 9.69 C

ATOM 3070 CB TRP B 31 -4.584 54.386 53.429 1.00 9.75 C

ATOM 3071 CG TRP B 31 -3.774 53.752 52.328 1.00 9.51 C

ATOM 3072 CDl TRP B 31 -2.613 54.228 51.773 1.00 10.15 C

ATOM 3073 NEl TRP B 31 -2.173 53.371 50.789 1.00 10.74 N

ATOM 3074 CE2 TRP B 31 -3.043 52.315 50.697 1.00 10.42 C

ATOM 3075 CD2 TRP B 31 -4.067 52.524 51.652 1.00 10.25 C

ATOM 3076 CE3 TRP B 31 -5.096 51.577 51.762 1.00 9.99 C

ATOM 3077 CZ3 TRP B 31 -5.072 50.460 50.922 1.00 10.20 C

ATOM 3078 CH2 TRP B 31 -4.039 50.281 49.982 1.00 10.47 C

ATOM 3079 CZ2 TRP B 31 -3.020 51.195 49.853 1.00 11.03 C W2025-7029WO / AM102903-PCT

ATOM 3080 C TRP B 31 -5.144 56.568 52.274 1.00 9.89 C

ATOM 3081 O TRP B 31 -4.419 57.339 52.911 1.00 10.33 O

ATOM 3082 N ALA B 32 -5.492 56.785 51.002 1.00 9.94 N

ATOM 3083 CA ALA B 32 -5.080 57.989 50.272 1.00 9.99 C

ATOM 3084 CB ALA B 32 -5.481 57.884 48.805 1.00 9.88 C

ATOM 3085 C ALA B 32 -5.680 59.251 50.900 1.00 10.15 C

ATOM 3086 O ALA B 32 -5.126 60.345 50.782 1.00 10.17 O

ATOM 3087 N GLN B 33 -6.801 59.069 51.594 1.00 10.23 N

ATOM 3088 CA GLN B 33 -7.491 60.149 52.305 1.00 10.88 C

ATOM 3089 CB GLN B 33 -8.794 59.627 52.929 1.00 11.00 C

ATOM 3090 CG GLN B 33 -8.628 58.503 53.945 1.00 11.71 C

ATOM 3091 CD GLN B 33 -9.903 58.224 54.717 1.00 12.18 C

ATOM 3092 OEl GLN B 33 10.553 59.147 55.218 1.00 13.14 O

ATOM 3093 NE2 GLN B 33 10.272 56.953 54.813 1.00 12.89 N

ATOM 3094 C GLN B 33 -6.632 60.849 53.371 1.00 10.97 C

ATOM 3095 O GLN B 33 -6.924 61.984 53.753 1.00 10.90 O

ATOM 3096 N TYR B 34 -5.572 60.179 53.828 1.00 11.46 N

ATOM 3097 CA TYR B 34 -4.728 60.685 54.924 1.00 11.81 C

ATOM 3098 CB TYR B 34 -4.345 59.545 55.876 1.00 12.14 C

ATOM 3099 CG TYR B 34 -5.551 58.868 56.474 1.00 11.69 C

ATOM 3100 CDl TYR B 34 -6.498 59.602 57.197 1.00 12.34 C

ATOM 3101 CEl TYR B 34 -7.617 58.993 57.734 1.00 12.18 C

ATOM 3102 CZ TYR B 34 -7.805 57.630 57.558 1.00 12.49 C

ATOM 3103 OH TYR B 34 -8.911 57.022 58.094 1.00 13.08 O

ATOM 3104 CE2 TYR B 34 -6.885 56.877 56.844 1.00 12.19 C

ATOM 3105 CD2 TYR B 34 -5.764 57.504 56.303 1.00 12.14 C

ATOM 3106 C TYR B 34 -3.476 61.452 54.499 1.00 12.02 C

ATOM 3107 O TYR B 34 -2.762 61.994 55.346 1.00 12.20 O

ATOM 3108 N ARG B 35 -3.211 61.499 53.197 1.00 12.05 N

ATOM 3109 CA ARG B 35 -2.048 62.218 52.683 1.00 12.26 C

ATOM 3110 CB ARG B 35 -1.748 61.798 51.243 1.00 12.16 C

ATOM 3111 CG ARG B 35 -1.332 60.345 51.156 1.00 12.09 C

ATOM 3112 CD ARG B 35 -1.280 59.828 49.735 1.00 11.08 C

ATOM 3113 NE ARG B 35 -1.058 58.389 49.761 1.00 10.38 N

ATOM 3114 CZ ARG B 35 -1.448 57.540 48.818 1.00 11.05 C

ATOM 3115 NHl ARG B 35 -2.076 57.981 47.731 1.00 11.05 N

ATOM 3116 NH2 ARG B 35 -1.207 56.240 48.971 1.00 10.83 N

ATOM 3117 C ARG B 35 -2.271 63.722 52.784 1.00 12.75 C

ATOM 3118 O ARG B 35 -3.399 64.185 52.598 1.00 12.75 O

ATOM 3119 N PRO B 36 -1.203 64.480 53.094 1.00 13.34 N

ATOM 3120 CA PRO B 36 -1.319 65.928 53.292 1.00 13.70 C

ATOM 3121 CB PRO B 36 0.054 66.317 53.847 1.00 13.82 C

ATOM 3122 CG PRO B 36 0.981 65.289 53.303 1.00 13.71 C

ATOM 3123 CD PRO B 36 0.183 64.013 53.283 1.00 13.32 C

ATOM 3124 C PRO B 36 -1.592 66.695 52.002 1.00 13.90 C

ATOM 3125 O PRO B 36 -1.124 66.297 50.933 1.00 13.76 O

ATOM 3126 N GLY B 37 -2.356 67.781 52.122 1.00 13.92 N

ATOM 3127 CA GLY B 37 -2.563 68.738 51.031 1.00 14.17 C

ATOM 3128 C GLY B 37 -2.904 68.130 49.685 1.00 13.98 C

ATOM 3129 O GLY B 37 -3.900 67.419 49.552 1.00 14.18 O

ATOM 3130 N LEU B 38 -2.062 68.419 48.691 1.00 13.80 N

ATOM 3131 CA LEU B 38 -2.256 67.967 47.313 1.00 13.64 C

ATOM 3132 CB LEU B 38 -1.173 68.564 46.402 1.00 14.01 C

ATOM 3133 CG LEU B 38 -1.266 70.051 46.043 1.00 14.57 C

ATOM 3134 CDl LEU B 38 0.094 70.579 45.597 1.00 16.13 C

ATOM 3135 CD2 LEU B 38 -2.299 70.263 44.946 1.00 15.56 C

ATOM 3136 C LEU B 38 -2.281 66.441 47.163 1.00 13.49 C

ATOM 3137 O LEU B 38 -2.713 65.925 46.132 1.00 13.61 O

ATOM 3138 N GLY B 39 -1.817 65.727 48.189 1.00 13.02 N

ATOM 3139 CA GLY B 39 -1.793 64.264 48.169 1.00 12.94 C

ATOM 3140 C GLY B 39 -3.133 63.614 48.483 1.00 12.87 C

ATOM 3141 O GLY B 39 -3.386 62.478 48.074 1.00 12.72 O

ATOM 3142 N ARG B 40 -3.992 64.331 49.210 1.00 12.54 N W2025-7029WO / AM102903-PCT

ATOM 3143 CA ARG B 40 -5.281 63.791 49.644 1.00 12.69 C

ATOM 3144 CB ARG B 40 -6.028 64.800 50.526 1.00 13.01 C

ATOM 3145 CG ARG B 40 -7.384 64.303 51.024 1.00 14.36 C

ATOM 3146 CD ARG B 40 -7.977 65.237 52.074 1.00 16.82 C

ATOM 3147 NE ARG B 40 -9.415 65.037 52.269 1.00 19.56 N

ATOM 3148 CZ ARG B 40 -9.960 64.258 53.205 1.00 21.29 C

ATOM 3149 NHl ARG B 40 11.282 64.161 53.289 1.00 22.91 N

ATOM 3150 NH2 ARG B 40 -9.201 63.571 54.056 1.00 21.64 N

ATOM 3151 C ARG B 40 -6.146 63.389 48.454 1.00 12.28 C

ATOM 3152 O ARG B 40 -6.328 64.172 47.513 1.00 12.20 O

ATOM 3153 N PHE B 41 -6.675 62.169 48.502 1.00 11.75 N

ATOM 3154 CA PHE B 41 -7.485 61.653 47.407 1.00 11.62 C

ATOM 3155 CB PHE B 41 -6.639 60.791 46.459 1.00 11.28 C

ATOM 3156 CG PHE B 41 -7.333 60.452 45.168 1.00 11.21 C

ATOM 3157 CDl PHE B 41 -7.078 61.187 44.018 1.00 11.87 C

ATOM 3158 CEl PHE B 41 -7.720 60.884 42.817 1.00 11.96 C

ATOM 3159 CZ PHE B 41 -8.627 59.834 42.765 1.00 12.59 C

ATOM 3160 CE2 PHE B 41 -8.892 59.090 43.913 1.00 11.62 C

ATOM 3161 CD2 PHE B 41 -8.246 59.399 45.103 1.00 11.32 C

ATOM 3162 C PHE B 41 -8.687 60.873 47.921 1.00 11.80 C

ATOM 3163 O PHE B 41 -8.536 59.901 48.663 1.00 11.74 O

ATOM 3164 N MET B 42 -9.871 61.309 47.488 1.00 12.12 N

ATOM 3165 CA MET B 42 11.154 60.751 47.901 1.00 12.50 C

ATOM 3166 CB MET B 42 12.020 61.850 48.547 1.00 12.79 C

ATOM 3167 CG MET B 42 11.332 62.635 49.657 1.00 14.13 C

ATOM 3168 SD MET B 42 10.814 61.591 51.037 1.00 17.25 S

ATOM 3169 CE MET B 42 12.379 61.288 51.841 1.00 15.92 C

ATOM 3170 C MET B 42 11.876 60.165 46.679 1.00 12.40 C

ATOM 3171 O MET B 42 11.498 60.460 45.541 1.00 12.08 O

ATOM 3172 N PRO B 43 12.911 59.330 46.898 1.00 12.58 N

ATOM 3173 CA PRO B 43 13.659 58.786 45.757 1.00 12.91 C

ATOM 3174 CB PRO B 43 14.829 58.056 46.426 1.00 12.79 C

ATOM 3175 CG PRO B 43 14.285 57.648 47.758 1.00 12.81 C

ATOM 3176 CD PRO B 43 13.423 58.804 48.179 1.00 12.44 C

ATOM 3177 C PRO B 43 14.180 59.831 44.760 1.00 13.34 C

ATOM 3178 O PRO B 43 14.238 59.550 43.562 1.00 13.33 O

ATOM 3179 N ASP B 44 14.546 61.019 45.243 1.00 13.95 N

ATOM 3180 CA ASP B 44 15.103 62.055 44.359 1.00 14.62 C

ATOM 3181 CB ASP B 44 15.974 63.046 45.139 1.00 15.09 C

ATOM 3182 CG ASP B 44 17.348 62.483 45.447 1.00 16.40 C

ATOM 3183 ODl ASP B 44 18.115 62.221 44.493 1.00 19.02 O

ATOM 3184 OD2 ASP B 44 17.665 62.296 46.636 1.00 18.79 O

ATOM 3185 C ASP B 44 14.045 62.762 43.515 1.00 14.53 C

ATOM 3186 O ASP B 44 14.374 63.559 42.630 1.00 14.38 O

ATOM 3187 N ASP B 45 12.781 62.454 43.792 1.00 14.38 N

ATOM 3188 CA ASP B 45 11.666 62.912 42.971 1.00 14.36 C

ATOM 3189 CB ASP B 45 10.395 62.994 43.817 1.00 14.49 C

ATOM 3190 CG ASP B 45 10.518 64.005 44.942 1.00 15.53 C

ATOM 3191 ODl ASP B 45 10.963 65.140 44.667 1.00 16.71 O

ATOM 3192 OD2 ASP B 45 10.184 63.671 46.098 1.00 15.60 O

ATOM 3193 C ASP B 45 11.459 62.041 41.727 1.00 14.31 C

ATOM 3194 O ASP B 45 10.705 62.410 40.822 1.00 14.40 O

ATOM 3195 N ILE B 46 12.143 60.897 41.686 1.00 14.04 N

ATOM 3196 CA ILE B 46 12.065 59.981 40.554 1.00 14.12 C

ATOM 3197 CB ILE B 46 12.588 58.559 40.916 1.00 13.81 C

ATOM 3198 CGl ILE B 46 11.743 57.925 42.034 1.00 13.31 C

ATOM 3199 CDl ILE B 46 12.274 56.572 42.543 1.00 13.47 C

ATOM 3200 CG2 ILE B 46 12.627 57.657 39.662 1.00 14.24 C

ATOM 3201 C ILE B 46 12.898 60.535 39.404 1.00 14.38 C

ATOM 3202 O ILE B 46 14.073 60.856 39.593 1.00 13.95 O

ATOM 3203 N ASN B 47 12.278 60.666 38.230 1.00 14.67 N

ATOM 3204 CA ASN B 47 13.002 60.973 37.000 1.00 15.44 C

ATOM 3205 CB ASN B 47 12.028 61.418 35.896 1.00 15.61 C W2025-7029WO / AM102903-PCT

ATOM 3206 CG ASN B 47 12.722 61.745 34.567 1.00 16.51 C

ATOM 3207 ODl ASN B 47 13.851 61.320 34.303 1.00 16.88 O

ATOM 3208 ND2 ASN B 47 12.028 62.500 33.718 1.00 17.05 N

ATOM 3209 C ASN B 47 13.762 59.714 36.583 1.00 15.70 C

ATOM 3210 O ASN B 47 13.146 58.697 36.267 1.00 15.58 O

ATOM 3211 N PRO B 48 15.105 59.777 36.585 1.00 16.07 N

ATOM 3212 CA PRO B 48 15.939 58.603 36.313 1.00 16.44 C

ATOM 3213 CB PRO B 48 17.356 59.109 36.607 1.00 16.35 C

ATOM 3214 CG PRO B 48 17.281 60.571 36.382 1.00 16.65 C

ATOM 3215 CD PRO B 48 15.921 60.980 36.843 1.00 16.13 C

ATOM 3216 C PRO B 48 15.839 58.091 34.871 1.00 16.80 C

ATOM 3217 O PRO B 48 16.307 56.990 34.584 1.00 16.75 O

ATOM 3218 N CYS B 49 15.228 58.889 33.994 1.00 17.63 N

ATOM 3219 CA CYS B 49 15.091 58.575 32.564 1.00 18.58 C

ATOM 3220 CB CYS B 49 15.197 59.855 31.726 1.00 19.32 C

ATOM 3221 SG CYS B 49 16.673 60.838 32.037 1.00 24.92 S

ATOM 3222 C CYS B 49 13.774 57.896 32.217 1.00 17.79 C

ATOM 3223 O CYS B 49 13.589 57.428 31.093 1.00 17.90 O

ATOM 3224 N LEU B 50 12.860 57.849 33.181 1.00 17.05 N

ATOM 3225 CA LEU B 50 11.484 57.453 32.913 1.00 16.47 C

ATOM 3226 CB LEU B 50 10.589 57.947 34.051 1.00 16.75 C

ATOM 3227 CG LEU B 50 -9.078 58.054 33.864 1.00 17.76 C

ATOM 3228 CDl LEU B 50 -8.695 59.017 32.737 1.00 18.31 C

ATOM 3229 CD2 LEU B 50 -8.462 58.496 35.179 1.00 17.73 C

ATOM 3230 C LEU B 50 11.316 55.944 32.699 1.00 15.81 C

ATOM 3231 O LEU B 50 10.720 55.512 31.708 1.00 15.64 O

ATOM 3232 N CYS B 51 11.857 55.160 33.628 1.00 14.80 N

ATOM 3233 CA CYS B 51 11.704 53.709 33.631 1.00 14.16 C

ATOM 3234 CB CYS B 51 11.124 53.265 34.975 1.00 14.13 C

ATOM 3235 SG CYS B 51 -9.765 54.300 35.564 1.00 13.98

ATOM 3236 C CYS B 51 13.040 53.006 33.379 1.00 13.91 C

ATOM 3237 O CYS B 51 14.112 53.607 33.546 1.00 14.14 O

ATOM 3238 N THR B 52 12.969 51.739 32.974 1.00 13.16 N

ATOM 3239 CA THR B 52 14.166 50.930 32.736 1.00 12.82 C

ATOM 3240 CB THR B 52 13.945 49.858 31.650 1.00 12.98 C

ATOM 3241 OGl THR B 52 12.907 48.953 32.067 1.00 12.92 O

ATOM 3242 CG2 THR B 52 13.578 50.494 30.317 1.00 13.58 C

ATOM 3243 C THR B 52 14.614 50.224 34.012 1.00 12.36 C

ATOM 3244 O THR B 52 15.798 49.929 34.183 1.00 12.47 O

ATOM 3245 N HIS B 53 13.650 49.926 34.881 1.00 11.68 N

ATOM 3246 CA HIS B 53 13.907 49.282 36.168 1.00 11.02 C

ATOM 3247 CB HIS B 53 13.472 47.812 36.152 1.00 11.43 C

ATOM 3248 CG HIS B 53 14.276 46.939 35.235 1.00 12.40 C

ATOM 3249 NDl HIS B 53 14.208 47.035 33.862 1.00 13.17 N

ATOM 3250 CEl HIS B 53 15.008 46.135 33.320 1.00 13.63 C

ATOM 3251 NE2 HIS B 53 15.584 45.450 34.290 1.00 13.35 N

ATOM 3252 CD2 HIS B 53 15.141 45.931 35.498 1.00 13.04 C

ATOM 3253 C HIS B 53 13.128 50.008 37.250 1.00 10.66 C

ATOM 3254 O HIS B 53 11.984 50.416 37.031 1.00 10.20 O

ATOM 3255 N LEU B 54 13.752 50.169 38.411 1.00 9.84 N

ATOM 3256 CA LEU B 54 13.084 50.731 39.577 1.00 9.64 C

ATOM 3257 CB LEU B 54 13.766 52.028 40.021 1.00 9.94 C

ATOM 3258 CG LEU B 54 13.832 53.184 39.019 1.00 10.55 C

ATOM 3259 CDl LEU B 54 14.708 54.293 39.577 1.00 11.85 C

ATOM 3260 CD2 LEU B 54 12.452 53.720 38.696 1.00 11.45 C

ATOM 3261 C LEU B 54 13.106 49.723 40.713 1.00 9.65 C

ATOM 3262 O LEU B 54 14.153 49.141 41.021 1.00 9.68 O

ATOM 3263 N ILE B 55 11.952 49.505 41.336 1.00 9.39 N

ATOM 3264 CA ILE B 55 11.878 48.552 42.441 1.00 9.37 C

ATOM 3265 CB ILE B 55 10.999 47.317 42.099 1.00 9.13 C

ATOM 3266 CGl ILE B 55 11.449 46.705 40.760 1.00 8.91 C

ATOM 3267 CDl ILE B 55 10.842 45.335 40.441 1.00 9.88 C

ATOM 3268 CG2 ILE B 55 11.046 46.290 43.239 1.00 9.68 C W2025-7029WO / AM102903-PCT

ATOM 3269 C ILE B 55 11.425 49.236 43.727 1.00 9.36 C

ATOM 3270 O ILE B 55 10.463 50.010 43.732 1.00 9.47 O

ATOM 3271 N TYR B 56 12.148 48.959 44.807 1.00 9.34 N

ATOM 3272 CA TYR B 56 11.939 49.613 46.090 1.00 9.37 C

ATOM 3273 CB TYR B 56 13.292 49.831 46.771 1.00 9.46 C

ATOM 3274 CG TYR B 56 13.291 50.727 47.996 1.00 10.19 C

ATOM 3275 CDl TYR B 56 13.854 52.001 47.938 1.00 9.82 C

ATOM 3276 CEl TYR B 56 13.886 52.829 49.051 1.00 10.66 C

ATOM 3277 CZ TYR B 56 13.359 52.385 50.254 1.00 10.33 C

ATOM 3278 OH TYR B 56 13.404 53.223 51.339 1.00 11.60 O

ATOM 3279 CE2 TYR B 56 12.792 51.119 50.354 1.00 10.12 C

ATOM 3280 CD2 TYR B 56 12.765 50.289 49.223 1.00 9.89 C

ATOM 3281 C TYR B 56 11.041 48.754 46.978 1.00 9.22 C

ATOM 3282 O TYR B 56 11.394 47.631 47.335 1.00 9.26 O

ATOM 3283 N ALA B 57 -9.887 49.300 47.336 1.00 8.90 N

ATOM 3284 CA ALA B 57 -8.940 48.624 48.227 1.00 8.60 C

ATOM 3285 CB ALA B 57 -7.553 48.621 47.592 1.00 8.95 C

ATOM 3286 C ALA B 57 -8.904 49.342 49.586 1.00 8.73 C

ATOM 3287 O ALA B 57 -8.665 50.552 49.613 1.00 8.83 O

ATOM 3288 N PHE B 58 -9.141 48.653 50.714 1.00 8.71 N

ATOM 3289 CA PHE B 58 -9.472 47.217 50.812 1.00 8.94 C

ATOM 3290 CB PHE B 58 -8.269 46.411 51.329 1.00 9.08 C

ATOM 3291 CG PHE B 58 -7.160 46.218 50.325 1.00 9.15 C

ATOM 3292 CDl PHE B 58 -5.926 46.847 50.504 1.00 8.32 C

ATOM 3293 CEl PHE B 58 -4.892 46.668 49.581 1.00 9.50 C

ATOM 3294 CZ PHE B 58 -5.086 45.841 48.475 1.00 9.34 C

ATOM 3295 CE2 PHE B 58 -6.309 45.202 48.290 1.00 8.99 C

ATOM 3296 CD2 PHE B 58 -7.338 45.391 49.219 1.00 9.37 C

ATOM 3297 C PHE B 58 10.592 46.976 51.824 1.00 9.05 C

ATOM 3298 O PHE B 58 10.811 47.789 52.731 1.00 9.18 O

ATOM 3299 N ALA B 59 11.277 45.842 51.678 1.00 9.24 N

ATOM 3300 CA ALA B 59 12.082 45.276 52.757 1.00 9.53 C

ATOM 3301 CB ALA B 59 13.263 44.521 52.195 1.00 9.73 C

ATOM 3302 C ALA B 59 11.212 44.342 53.599 1.00 9.98 C

ATOM 3303 O ALA B 59 10.145 43.900 53.154 1.00 9.28 O

ATOM 3304 N GLY B 60 11.678 44.038 54.808 1.00 9.99 N

ATOM 3305 CA GLY B 60 11.003 43.087 55.682 1.00 11.22 C

ATOM 3306 C GLY B 60 11.885 41.900 56.003 1.00 11.63 C

ATOM 3307 O GLY B 60 12.858 41.615 55.292 1.00 11.69 O

ATOM 3308 N MET B 61 11.540 41.204 57.081 1.00 12.31 N

ATOM 3309 CA MET B 61 12.277 40.016 57.489 1.00 12.99 C

ATOM 3310 CB MET B 61 11.647 38.753 56.888 1.00 12.62 C

ATOM 3311 CG MET B 61 12.583 37.546 56.841 1.00 13.25 C

ATOM 3312 SD MET B 61 11.764 35.990 56.395 1.00 13.35 S

ATOM 3313 CE MET B 61 11.156 36.384 54.751 1.00 12.27 C

ATOM 3314 C MET B 61 12.331 39.914 59.003 1.00 13.80 C

ATOM 3315 O MET B 61 11.340 40.167 59.694 1.00 13.83 O

ATOM 3316 N GLN B 62 13.501 39.538 59.508 1.00 14.62 N

ATOM 3317 CA GLN B 62 13.702 39.333 60.934 1.00 15.64 C

ATOM 3318 CB GLN B 62 14.260 40.608 61.584 1.00 16.20 C

ATOM 3319 CG GLN B 62 14.630 40.477 63.063 1.00 19.91 C

ATOM 3320 CD GLN B 62 13.430 40.445 64.007 1.00 24.11 C

ATOM 3321 OEl GLN B 62 12.271 40.592 63.590 1.00 26.96 O

ATOM 3322 NE2 GLN B 62 13.708 40.261 65.298 1.00 25.50 N

ATOM 3323 C GLN B 62 14.648 38.146 61.131 1.00 15.34 C

ATOM 3324 O GLN B 62 15.749 38.121 60.576 1.00 15.20 O

ATOM 3325 N ASN B 63 14.201 37.164 61.914 1.00 15.29 N

ATOM 3326 CA ASN B 63 14.969 35.939 62.139 1.00 15.46 C

ATOM 3327 CB ASN B 63 16.102 36.195 63.143 1.00 16.06 C

ATOM 3328 CG ASN B 63 15.592 36.719 64.476 1.00 17.99 C

ATOM 3329 ODl ASN B 63 14.656 36.169 65.057 1.00 21.40 O

ATOM 3330 ND2 ASN B 63 16.206 37.789 64.962 1.00 20.48 N

ATOM 3331 C ASN B 63 15.497 35.331 60.829 1.00 14.92 C W2025-7029WO / AM102903-PCT

ATOM 3332 O ASN B 63 16.664 34.954 60.720 1.00 15.00 O

ATOM 3333 N ASN B 64 14.611 35.264 59.837 1.00 14.32 N

ATOM 3334 CA ASN B 64 14.908 34.687 58.518 1.00 13.72 C

ATOM 3335 CB ASN B 64 15.315 33.213 58.649 1.00 13.87 C

ATOM 3336 CG ASN B 64 14.228 32.372 59.282 1.00 13.83 C

ATOM 3337 ODl ASN B 64 13.107 32.305 58.777 1.00 13.29 O

ATOM 3338 ND2 ASN B 64 14.551 31.729 60.395 1.00 14.18 N

ATOM 3339 C ASN B 64 15.921 35.466 57.679 1.00 13.52 C

ATOM 3340 O ASN B 64 16.470 34.935 56.717 1.00 13.06 O

ATOM 3341 N GLU B 65 16.142 36.729 58.033 1.00 13.27 N

ATOM 3342 CA GLU B 65 17.067 37.591 57.301 1.00 13.07 C

ATOM 3343 CB GLU B 65 18.241 37.991 58.199 1.00 13.31 C

ATOM 3344 CG GLU B 65 19.100 36.802 58.619 1.00 14.12 C

ATOM 3345 CD GLU B 65 20.292 37.187 59.477 1.00 15.59 C

ATOM 3346 OEl GLU B 65 21.361 36.559 59.311 1.00 17.71 O

ATOM 3347 OE2 GLU B 65 20.162 38.098 60.320 1.00 16.86 O

ATOM 3348 C GLU B 65 16.338 38.825 56.793 1.00 12.88 C

ATOM 3349 O GLU B 65 15.435 39.337 57.460 1.00 12.91 O

ATOM 3350 N ILE B 66 16.719 39.289 55.606 1.00 12.63 N

ATOM 3351 CA ILE B 66 16.117 40.495 55.034 1.00 12.86 C

ATOM 3352 CB ILE B 66 16.478 40.669 53.532 1.00 12.70 C

ATOM 3353 CGl ILE B 66 15.632 41.772 52.886 1.00 12.85 C

ATOM 3354 CDl ILE B 66 15.679 41.760 51.365 1.00 13.16 C

ATOM 3355 CG2 ILE B 66 17.972 40.925 53.338 1.00 12.57 C

ATOM 3356 C ILE B 66 16.509 41.725 55.861 1.00 13.07 C

ATOM 3357 O ILE B 66 17.633 41.820 56.366 1.00 13.14 O

ATOM 3358 N THR B 67 15.576 42.657 56.017 1.00 13.12 N

ATOM 3359 CA THR B 67 15.826 43.840 56.833 1.00 13.57 C

ATOM 3360 CB THR B 67 15.491 43.569 58.330 1.00 14.00 C

ATOM 3361 OGl THR B 67 16.139 44.544 59.160 1.00 16.44 O

ATOM 3362 CG2 THR B 67 13.973 43.591 58.568 1.00 14.08 C

ATOM 3363 C THR B 67 15.067 45.060 56.309 1.00 13.23 C

ATOM 3364 O THR B 67 14.164 44.930 55.478 1.00 12.92 O

ATOM 3365 N THR B 68 15.464 46.241 56.781 1.00 12.87 N

ATOM 3366 CA THR B 68 14.728 47.481 56.523 1.00 12.76 C

ATOM 3367 CB THR B 68 15.544 48.714 56.951 1.00 12.84 C

ATOM 3368 OGl THR B 68 15.871 48.609 58.343 1.00 12.62 O

ATOM 3369 CG2 THR B 68 16.827 48.823 56.131 1.00 13.21 C

ATOM 3370 C THR B 68 13.433 47.482 57.325 1.00 12.63 C

ATOM 3371 O THR B 68 13.278 46.687 58.254 1.00 12.82 O

ATOM 3372 N ILE B 69 12.503 48.365 56.968 1.00 12.49 N

ATOM 3373 CA ILE B 69 11.276 48.540 57.751 1.00 12.47 C

ATOM 3374 CB ILE B 69 10.021 47.922 57.065 1.00 12.44 C

ATOM 3375 CGl ILE B 69 -9.738 48.610 55.723 1.00 12.60 C

ATOM 3376 CDl ILE B 69 -8.442 48.182 55.067 1.00 13.05 C

ATOM 3377 CG2 ILE B 69 10.169 46.401 56.923 1.00 12.33 C

ATOM 3378 C ILE B 69 10.991 49.985 58.167 1.00 12.45 C

ATOM 3379 O ILE B 69 10.223 50.212 59.102 1.00 12.75 O

ATOM 3380 N GLU B 70 11.588 50.956 57.475 1.00 12.11 N

ATOM 3381 CA GLU B 70 11.481 52.366 57.883 1.00 12.00 C

ATOM 3382 CB GLU B 70 11.029 53.253 56.717 1.00 11.74 C

ATOM 3383 CG GLU B 70 -9.627 52.947 56.171 1.00 12.67 C

ATOM 3384 CD GLU B 70 -8.497 53.555 56.997 1.00 13.63 C

ATOM 3385 OEl GLU B 70 -7.314 53.295 56.671 1.00 15.12 O

ATOM 3386 OE2 GLU B 70 -8.778 54.289 57.962 1.00 13.36 O

ATOM 3387 C GLU B 70 12.820 52.870 58.425 1.00 11.65 C

ATOM 3388 O GLU B 70 13.877 52.488 57.931 1.00 11.18 O

ATOM 3389 N TRP B 71 12.757 53.747 59.425 1.00 11.69 N

ATOM 3390 CA TRP B 71 13.949 54.296 60.091 1.00 11.99 C

ATOM 3391 CB TRP B 71 13.531 55.420 61.048 1.00 11.89 C

ATOM 3392 CG TRP B 71 12.976 56.620 60.338 1.00 13.49 C

ATOM 3393 CDl TRP B 71 11.731 56.748 59.789 1.00 14.14 C

ATOM 3394 NEl TRP B 71 11.597 57.987 59.203 1.00 14.90 N W2025-7029WO / AM102903-PCT

ATOM 3395 CE2 TRP B 71 12.769 58.678 59.352 1.00 14.66 C

ATOM 3396 CD2 TRP B 71 13.668 57.841 60.057 1.00 14.05 C

ATOM 3397 CE3 TRP B 71 14.954 58.322 60.351 1.00 14.41 C

ATOM 3398 CZ3 TRP B 71 15.299 59.608 59.925 1.00 14.52 C

ATOM 3399 CH2 TRP B 71 14.382 60.410 59.223 1.00 15.48 C

ATOM 3400 CZ2 TRP B 71 13.117 59.966 58.928 1.00 14.52 C

ATOM 3401 C TRP B 71 15.028 54.811 59.129 1.00 11.95 C

ATOM 3402 O TRP B 71 16.229 54.645 59.380 1.00 12.13 O

ATOM 3403 N ASN B 72 14.597 55.436 58.036 1.00 11.83 N

ATOM 3404 CA ASN B 72 15.522 56.074 57.095 1.00 11.61 C

ATOM 3405 CB ASN B 72 15.077 57.514 56.783 1.00 11.60 C

ATOM 3406 CG ASN B 72 13.670 57.593 56.178 1.00 11.82 C

ATOM 3407 ODl ASN B 72 12.883 56.648 56.255 1.00 11.32 O

ATOM 3408 ND2 ASN B 72 13.354 58.738 55.580 1.00 12.30 N

ATOM 3409 C ASN B 72 15.764 55.291 55.801 1.00 11.63 C

ATOM 3410 O ASN B 72 16.284 55.852 54.828 1.00 11.46 O

ATOM 3411 N ASP B 73 15.423 54.001 55.793 1.00 11.24 N

ATOM 3412 CA ASP B 73 15.605 53.174 54.589 1.00 11.34 C

ATOM 3413 CB ASP B 73 15.188 51.714 54.833 1.00 11.16 C

ATOM 3414 CG ASP B 73 13.708 51.457 54.545 1.00 11.04 C

ATOM 3415 ODl ASP B 73 13.082 52.236 53.788 1.00 10.83 O

ATOM 3416 OD2 ASP B 73 13.171 50.453 55.072 1.00 10.53 O

ATOM 3417 C ASP B 73 17.029 53.233 54.022 1.00 11.61 C

ATOM 3418 O ASP B 73 17.213 53.347 52.806 1.00 11.44 O

ATOM 3419 N VAL B 74 18.037 53.168 54.892 1.00 11.90 N

ATOM 3420 CA VAL B 74 19.424 53.176 54.417 1.00 11.98 C

ATOM 3421 CB VAL B 74 20.443 52.933 55.564 1.00 12.10 C

ATOM 3422 CGl VAL B 74 21.878 53.190 55.095 1.00 12.59 C

ATOM 3423 CG2 VAL B 74 20.306 51.501 56.090 1.00 12.56 C

ATOM 3424 C VAL B 74 19.739 54.450 53.606 1.00 11.86 C

ATOM 3425 O VAL B 74 20.315 54.367 52.519 1.00 11.88 O

ATOM 3426 N THR B 75 19.330 55.607 54.121 1.00 11.99 N

ATOM 3427 CA THR B 75 19.491 56.877 53.404 1.00 12.55 C

ATOM 3428 CB THR B 75 19.059 58.083 54.276 1.00 12.81 C

ATOM 3429 OGl THR B 75 19.745 58.039 55.534 1.00 14.26 O

ATOM 3430 CG2 THR B 75 19.373 59.405 53.584 1.00 13.43 C

ATOM 3431 C THR B 75 18.695 56.869 52.095 1.00 12.13 C

ATOM 3432 O THR B 75 19.182 57.325 51.059 1.00 12.15 O

ATOM 3433 N LEU B 76 17.482 56.324 52.152 1.00 11.88 N

ATOM 3434 CA LEU B 76 16.627 56.224 50.972 1.00 11.78 C

ATOM 3435 CB LEU B 76 15.199 55.833 51.363 1.00 11.56 C

ATOM 3436 CG LEU B 76 14.450 56.831 52.260 1.00 11.78 C

ATOM 3437 CDl LEU B 76 13.032 56.354 52.527 1.00 12.60 C

ATOM 3438 CD2 LEU B 76 14.449 58.242 51.669 1.00 10.98 C

ATOM 3439 C LEU B 76 17.199 55.282 49.914 1.00 11.71 C

ATOM 3440 O LEU B 76 17.105 55.573 48.722 1.00 11.69 O

ATOM 3441 N TYR B 77 17.793 54.167 50.353 1.00 11.52 N

ATOM 3442 CA TYR B 77 18.490 53.240 49.454 1.00 11.78 C

ATOM 3443 CB TYR B 77 19.177 52.107 50.217 1.00 11.51 C

ATOM 3444 CG TYR B 77 18.300 51.076 50.892 1.00 11.08 C

ATOM 3445 CDl TYR B 77 16.937 50.961 50.606 1.00 10.24 C

ATOM 3446 CEl TYR B 77 16.148 49.987 51.242 1.00 10.51 C

ATOM 3447 CZ TYR B 77 16.737 49.113 52.152 1.00 11.12 C

ATOM 3448 OH TYR B 77 15.983 48.150 52.784 1.00 11.40 O

ATOM 3449 CE2 TYR B 77 18.089 49.207 52.438 1.00 10.86 C

ATOM 3450 CD2 TYR B 77 18.861 50.178 51.804 1.00 10.83 C

ATOM 3451 C TYR B 77 19.577 53.970 48.683 1.00 12.23 C

ATOM 3452 O TYR B 77 19.708 53.799 47.472 1.00 12.40 O

ATOM 3453 N GLN B 78 20.368 54.764 49.405 1.00 12.64 N

ATOM 3454 CA GLN B 78 21.474 55.515 48.815 1.00 13.60 C

ATOM 3455 CB GLN B 78 22.235 56.312 49.887 1.00 13.97 C

ATOM 3456 CG GLN B 78 23.500 57.004 49.353 1.00 16.49 C

ATOM 3457 CD GLN B 78 23.982 58.172 50.219 1.00 19.21 C W2025-7029WO / AM102903-PCT

ATOM 3458 OEl GLN B 78 23.423 58.466 51.282 1.00 21.81 O

ATOM 3459 NE2 GLN B 78 25.027 58.847 49.753 1.00 21.74 N

ATOM 3460 C GLN B 78 20.987 56.448 47.705 1.00 13.19 C

ATOM 3461 O GLN B 78 21.566 56.484 46.618 1.00 13.38 O

ATOM 3462 N ALA B 79 19.917 57.188 47.988 1.00 13.01 N

ATOM 3463 CA ALA B 79 19.329 58.122 47.029 1.00 12.66 C

ATOM 3464 CB ALA B 79 18.294 58.992 47.708 1.00 12.82 C

ATOM 3465 C ALA B 79 18.713 57.384 45.840 1.00 12.53 C

ATOM 3466 O ALA B 79 18.869 57.804 44.695 1.00 12.27 O

ATOM 3467 N PHE B 80 18.019 56.287 46.140 1.00 12.28 N

ATOM 3468 CA PHE B 80 17.357 55.442 45.145 1.00 12.25 C

ATOM 3469 CB PHE B 80 16.604 54.320 45.871 1.00 11.97 C

ATOM 3470 CG PHE B 80 15.668 53.528 44.999 1.00 11.95 C

ATOM 3471 CDl PHE B 80 16.004 52.236 44.600 1.00 11.53 C

ATOM 3472 CEl PHE B 80 15.132 51.478 43.812 1.00 11.69 C

ATOM 3473 CZ PHE B 80 13.905 52.018 43.424 1.00 11.43 C

ATOM 3474 CE2 PHE B 80 13.555 53.303 43.820 1.00 11.57 C

ATOM 3475 CD2 PHE B 80 14.433 54.053 44.615 1.00 12.01 C

ATOM 3476 C PHE B 80 18.359 54.844 44.164 1.00 12.51 C

ATOM 3477 O PHE B 80 18.234 55.019 42.951 1.00 12.75 O

ATOM 3478 N ASN B 81 19.352 54.140 44.695 1.00 12.73 N

ATOM 3479 CA ASN B 81 20.367 53.517 43.859 1.00 13.12 C

ATOM 3480 CB ASN B 81 21.083 52.403 44.626 1.00 13.33 C

ATOM 3481 CG ASN B 81 20.156 51.230 44.918 1.00 13.59 C

ATOM 3482 ODl ASN B 81 19.340 50.854 44.073 1.00 14.61 O

ATOM 3483 ND2 ASN B 81 20.257 50.667 46.114 1.00 13.28 N

ATOM 3484 C ASN B 81 21.324 54.536 43.241 1.00 13.55 C

ATOM 3485 O ASN B 81 21.904 54.283 42.188 1.00 13.99 O

ATOM 3486 N GLY B 82 21.445 55.699 43.880 1.00 13.85 N

ATOM 3487 CA GLY B 82 22.188 56.834 43.321 1.00 14.70 C

ATOM 3488 C GLY B 82 21.621 57.367 42.012 1.00 15.12 C

ATOM 3489 O GLY B 82 22.313 58.064 41.272 1.00 15.49 O

ATOM 3490 N LEU B 83 20.361 57.039 41.721 1.00 15.27 N

ATOM 3491 CA LEU B 83 19.734 57.425 40.451 1.00 15.79 C

ATOM 3492 CB LEU B 83 18.250 57.047 40.439 1.00 15.92 C

ATOM 3493 CG LEU B 83 17.322 57.848 41.358 1.00 15.87 C

ATOM 3494 CDl LEU B 83 16.025 57.087 41.582 1.00 15.85 C

ATOM 3495 CD2 LEU B 83 17.041 59.249 40.810 1.00 16.44 C

ATOM 3496 C LEU B 83 20.449 56.806 39.251 1.00 16.11 C

ATOM 3497 O LEU B 83 20.387 57.336 38.139 1.00 16.00 O

ATOM 3498 N LYS B 84 21.136 55.692 39.498 1.00 16.60 N

ATOM 3499 CA LYS B 84 21.927 54.999 38.482 1.00 17.57 C

ATOM 3500 CB LYS B 84 22.335 53.611 38.984 1.00 17.43 C

ATOM 3501 CG LYS B 84 21.227 52.563 38.840 1.00 18.03 C

ATOM 3502 CD LYS B 84 21.243 51.517 39.950 1.00 18.98 C

ATOM 3503 CE LYS B 84 22.506 50.684 39.986 1.00 19.94 C

ATOM 3504 NZ LYS B 84 22.462 49.711 41.119 1.00 15.94 N

ATOM 3505 C LYS B 84 23.151 55.803 38.038 1.00 18.22 C

ATOM 3506 O LYS B 84 23.739 55.512 36.993 1.00 18.31 O

ATOM 3507 N ASN B 85 23.521 56.811 38.829 1.00 19.13 N

ATOM 3508 CA ASN B 85 24.575 57.760 38.454 1.00 20.27 C

ATOM 3509 CB ASN B 85 25.086 58.518 39.687 1.00 20.48 C

ATOM 3510 CG ASN B 85 25.816 57.612 40.672 1.00 21.54 C

ATOM 3511 ODl ASN B 85 26.513 56.674 40.277 1.00 22.75 O

ATOM 3512 ND2 ASN B 85 25.660 57.894 41.963 1.00 23.52 N

ATOM 3513 C ASN B 85 24.120 58.740 37.366 1.00 20.75 C

ATOM 3514 O ASN B 85 24.945 59.386 36.711 1.00 21.14 O

ATOM 3515 N LYS B 86 22.806 58.835 37.169 1.00 21.07 N

ATOM 3516 CA LYS B 86 22.231 59.726 36.161 1.00 21.39 C

ATOM 3517 CB LYS B 86 21.084 60.545 36.758 1.00 21.49 C

ATOM 3518 CG LYS B 86 21.455 61.241 38.058 1.00 22.71 C

ATOM 3519 CD LYS B 86 20.512 62.373 38.414 1.00 24.71 C

ATOM 3520 CE LYS B 86 20.942 63.010 39.732 1.00 25.99 C W2025-7029WO / AM102903-PCT

ATOM 3521 NZ LYS B 86 20.364 64.367 39.934 1.00 27.41 N

ATOM 3522 C LYS B 86 21.771 58.955 34.925 1.00 21.56 C

ATOM 3523 O LYS B 86 21.616 59.529 33.847 1.00 21.62 O

ATOM 3524 N ASN B 87 21.555 57.654 35.097 1.00 21.80 N

ATOM 3525 CA ASN B 87 21.183 56.762 34.007 1.00 22.05 C

ATOM 3526 CB ASN B 87 19.659 56.570 33.960 1.00 21.87 C

ATOM 3527 CG ASN B 87 19.200 55.698 32.791 1.00 22.20 C

ATOM 3528 ODl ASN B 87 20.010 55.118 32.064 1.00 21.18 O

ATOM 3529 ND2 ASN B 87 17.884 55.606 32.610 1.00 21.42 N

ATOM 3530 C ASN B 87 21.906 55.429 34.168 1.00 22.29 C

ATOM 3531 O ASN B 87 21.541 54.612 35.015 1.00 22.31 O

ATOM 3532 N SER B 88 22.935 55.225 33.349 1.00 22.53 N

ATOM 3533 CA SER B 88 23.785 54.035 33.409 1.00 22.74 C

ATOM 3534 CB SER B 88 25.061 54.257 32.587 1.00 22.76 C

ATOM 3535 OG SER B 88 24.757 54.570 31.243 1.00 23.59 O

ATOM 3536 C SER B 88 23.103 52.741 32.955 1.00 22.48 C

ATOM 3537 O SER B 88 23.638 51.668 33.162 1.00 22.79 O

ATOM 3538 N GLN B 89 21.940 52.872 32.318 1.00 22.01 N

ATOM 3539 CA GLN B 89 21.135 51.744 31.852 1.00 21.45 C

ATOM 3540 CB GLN B 89 20.232 52.196 30.701 1.00 21.85 C

ATOM 3541 CG GLN B 89 20.848 52.196 29.307 1.00 24.29 C

ATOM 3542 CD GLN B 89 22.356 52.101 29.311 1.00 26.47 C

ATOM 3543 OEl GLN B 89 23.062 53.074 29.601 1.00 28.19 O

ATOM 3544 NE2 GLN B 89 22.861 50.933 28.962 1.00 27.56 N

ATOM 3545 C GLN B 89 20.248 51.203 32.984 1.00 20.26 C

ATOM 3546 O GLN B 89 19.828 50.065 32.973 1.00 20.15 O

ATOM 3547 N LEU B 90 19.982 52.055 33.955 1.00 18.95 N

ATOM 3548 CA LEU B 90 19.003 51.776 34.987 1.00 17.63 C

ATOM 3549 CB LEU B 90 18.796 53.029 35.832 1.00 17.65 C

ATOM 3550 CG LEU B 90 17.625 53.106 36.800 1.00 17.96 C

ATOM 3551 CDl LEU B 90 16.315 52.992 36.049 1.00 18.03 C

ATOM 3552 CD2 LEU B 90 17.688 54.409 37.576 1.00 17.06 C

ATOM 3553 C LEU B 90 19.420 50.609 35.861 1.00 16.74 C

ATOM 3554 O LEU B 90 20.558 50.514 36.258 1.00 16.57 O

ATOM 3555 N LYS B 91 18.472 49.723 36.152 1.00 15.83 N

ATOM 3556 CA LYS B 91 18.680 48.645 37.116 1.00 15.11 C

ATOM 3557 CB LYS B 91 18.467 47.277 36.459 1.00 15.58 C

ATOM 3558 CG LYS B 91 19.394 46.974 35.280 1.00 17.01 C

ATOM 3559 CD LYS B 91 20.840 46.772 35.719 1.00 20.28 C

ATOM 3560 CE LYS B 91 21.732 46.465 34.521 1.00 22.46 C

ATOM 3561 NZ LYS B 91 23.179 46.559 34.863 1.00 25.09 N

ATOM 3562 C LYS B 91 17.700 48.824 38.268 1.00 14.29 C

ATOM 3563 O LYS B 91 16.578 49.288 38.065 1.00 13.96 O

ATOM 3564 N THR B 92 18.123 48.455 39.471 1.00 13.14 N

ATOM 3565 CA THR B 92 17.259 48.577 40.641 1.00 12.34 C

ATOM 3566 CB THR B 92 17.812 49.587 41.666 1.00 12.25 C

ATOM 3567 OGl THR B 92 19.123 49.183 42.081 1.00 12.56 O

ATOM 3568 CG2 THR B 92 17.860 50.996 41.075 1.00 11.98 C

ATOM 3569 C THR B 92 17.063 47.238 41.336 1.00 11.71 C

ATOM 3570 O THR B 92 17.958 46.391 41.352 1.00 11.65 O

ATOM 3571 N LEU B 93 15.883 47.044 41.908 1.00 10.95 N

ATOM 3572 CA LEU B 93 15.640 45.866 42.722 1.00 10.51 C

ATOM 3573 CB LEU B 93 14.788 44.824 41.978 1.00 10.46 C

ATOM 3574 CG LEU B 93 15.396 44.192 40.718 1.00 10.85 C

ATOM 3575 CDl LEU B 93 15.037 45.021 39.483 1.00 10.34 C

ATOM 3576 CD2 LEU B 93 14.922 42.751 40.550 1.00 11.71 C

ATOM 3577 C LEU B 93 14.980 46.283 44.018 1.00 10.26 C

ATOM 3578 O LEU B 93 14.411 47.376 44.111 1.00 10.11 O

ATOM 3579 N LEU B 94 15.080 45.409 45.012 1.00 9.54 N

ATOM 3580 CA LEU B 94 14.430 45.599 46.294 1.00 9.42 C

ATOM 3581 CB LEU B 94 15.449 45.429 47.420 1.00 9.15 C

ATOM 3582 CG LEU B 94 14.958 45.535 48.865 1.00 9.22 C

ATOM 3583 CDl LEU B 94 14.346 46.905 49.168 1.00 10.29 C W2025-7029WO / AM102903-PCT

ATOM 3584 CD2 LEU B 94 16.105 45.213 49.817 1.00 8.74 C

ATOM 3585 C LEU B 94 13.332 44.548 46.432 1.00 9.12 C

ATOM 3586 O LEU B 94 13.595 43.354 46.308 1.00 8.95 O

ATOM 3587 N ALA B 95 12.108 45.000 46.685 1.00 9.29 N

ATOM 3588 CA ALA B 95 10.984 44.091 46.870 1.00 8.84 C

ATOM 3589 CB ALA B 95 -9.692 44.719 46.361 1.00 9.07 C

ATOM 3590 C ALA B 95 10.856 43.741 48.344 1.00 8.95 C

ATOM 3591 O ALA B 95 10.941 44.617 49.203 1.00 9.25 O

ATOM 3592 N ILE B 96 10.669 42.457 48.633 1.00 9.00 N

ATOM 3593 CA ILE B 96 10.422 42.015 50.005 1.00 8.79 C

ATOM 3594 CB ILE B 96 11.431 40.924 50.479 1.00 8.69 C

ATOM 3595 CGl ILE B 96 11.188 40.580 51.958 1.00 8.74 C

ATOM 3596 CDl ILE B 96 12.281 39.725 52.607 1.00 9.03 C

ATOM 3597 CG2 ILE B 96 11.368 39.669 49.573 1.00 8.55 C

ATOM 3598 C ILE B 96 -8.990 41.512 50.154 1.00 8.67 C

ATOM 3599 O ILE B 96 -8.496 40.758 49.303 1.00 8.81 O

ATOM 3600 N GLY B 97 -8.330 41.930 51.235 1.00 8.71 N

ATOM 3601 CA GLY B 97 -7.006 41.412 51.563 1.00 9.10 C

ATOM 3602 C GLY B 97 -5.896 42.427 51.352 1.00 8.86 C

ATOM 3603 O GLY B 97 -5.878 43.477 51.994 1.00 9.34 O

ATOM 3604 N GLY B 98 -4.971 42.106 50.453 1.00 9.07 N

ATOM 3605 CA GLY B 98 -3.819 42.967 50.187 1.00 8.83 C

ATOM 3606 C GLY B 98 -2.552 42.438 50.833 1.00 9.29 C

ATOM 3607 O GLY B 98 -2.597 41.511 51.641 1.00 8.60 O

ATOM 3608 N TRP B 99 -1.417 43.024 50.466 1.00 9.56 N

ATOM 3609 CA TRP B 99 -0.126 42.547 50.959 1.00 10.23 C

ATOM 3610 CB TRP B 99 1.021 43.366 50.347 1.00 10.76 C

ATOM 3611 CG TRP B 99 2.373 43.020 50.885 1.00 12.31 C

ATOM 3612 CDl TRP B 99 3.033 43.657 51.896 1.00 13.40 C

ATOM 3613 NEl TRP B 99 4.250 43.060 52.119 1.00 14.32 N

ATOM 3614 CE2 TRP B 99 4.403 42.017 51.244 1.00 13.95 C

ATOM 3615 CD2 TRP B 99 3.238 41.959 50.447 1.00 13.65 C

ATOM 3616 CE3 TRP B 99 3.140 40.964 49.462 1.00 13.04 C

ATOM 3617 CZ3 TRP B 99 4.202 40.067 49.308 1.00 13.63 C

ATOM 3618 CH2 TRP B 99 5.350 40.157 50.115 1.00 14.03 C

ATOM 3619 CZ2 TRP B 99 5.470 41.123 51.084 1.00 14.31 C

ATOM 3620 C TRP B 99 -0.056 42.529 52.496 1.00 9.93 C

ATOM 3621 O TRP B 99 0.311 41.509 53.092 1.00 9.81 O

ATOM 3622 N ASN B 100 -0.413 43.645 53.131 1.00 9.88 N

ATOM 3623 CA ASN B 100 -0.271 43.765 54.588 1.00 9.92 C

ATOM 3624 CB ASN B 100 -0.432 45.221 55.030 1.00 10.17 C

ATOM 3625 CG ASN B 100 0.744 46.088 54.621 1.00 9.87 C

ATOM 3626 ODl ASN B 100 1.803 45.582 54.229 1.00 10.98 O

ATOM 3627 ND2 ASN B 100 0.568 47.403 54.715 1.00 9.41 N

ATOM 3628 C ASN B 100 -1.236 42.868 55.361 1.00 9.85 C

ATOM 3629 O ASN B 100 -1.011 42.561 56.535 1.00 10.53 O

ATOM 3630 N PHE B 101 -2.304 42.445 54.688 1.00 9.52 N

ATOM 3631 CA PHE B 101 -3.336 41.595 55.290 1.00 9.26 C

ATOM 3632 CB PHE B 101 -4.525 41.472 54.329 1.00 9.58 C

ATOM 3633 CG PHE B 101 -5.736 40.776 54.912 1.00 9.94 C

ATOM 3634 CDl PHE B 101 -6.622 41.466 55.744 1.00 11.24 C

ATOM 3635 CEl PHE B 101 -7.755 40.828 56.272 1.00 11.44 C

ATOM 3636 CZ PHE B 101 -8.021 39.500 55.946 1.00 10.80 C

ATOM 3637 CE2 PHE B 101 -7.161 38.801 55.106 1.00 9.83 C

ATOM 3638 CD2 PHE B 101 -6.019 39.449 54.582 1.00 10.42 C

ATOM 3639 C PHE B 101 -2.788 40.216 55.624 1.00 9.22 C

ATOM 3640 O PHE B 101 -3.268 39.564 56.550 1.00 9.24 O

ATOM 3641 N GLY B 102 -1.779 39.776 54.872 1.00 8.73 N

ATOM 3642 CA GLY B 102 -1.214 38.441 55.050 1.00 8.74 C

ATOM 3643 C GLY B 102 -2.182 37.334 54.663 1.00 8.42 C

ATOM 3644 O GLY B 102 -3.150 37.560 53.919 1.00 8.05 O

ATOM 3645 N THR B 103 -1.936 36.136 55.193 1.00 8.36 N

ATOM 3646 CA THR B 103 -2.663 34.941 54.772 1.00 8.72 C W2025-7029WO / AM102903-PCT

ATOM 3647 CB THR B 103 -1.705 33.867 54.240 1.00 8.70 C

ATOM 3648 OGl THR B 103 -0.782 33.509 55.278 1.00 8.92 O

ATOM 3649 CG2 THR B 103 -0.936 34.387 53.017 1.00 8.56 C

ATOM 3650 C THR B 103 -3.522 34.285 55.855 1.00 8.90 C

ATOM 3651 O THR B 103 -4.423 33.509 55.528 1.00 9.06 O

ATOM 3652 N ALA B 104 -3.244 34.580 57.128 1.00 9.20 N

ATOM 3653 CA ALA B 104 -3.908 33.879 58.239 1.00 8.99 C

ATOM 3654 CB ALA B 104 -3.408 34.392 59.608 1.00 9.07 C

ATOM 3655 C ALA B 104 -5.451 33.851 58.172 1.00 9.23 C

ATOM 3656 O ALA B 104 -6.033 32.770 58.276 1.00 9.13 O

ATOM 3657 N PRO B 105 -6.118 35.021 57.996 1.00 9.46 N

ATOM 3658 CA PRO B 105 -7.584 34.951 57.907 1.00 9.50 C

ATOM 3659 CB PRO B 105 -8.009 36.430 57.848 1.00 9.72 C

ATOM 3660 CG PRO B 105 -6.835 37.189 58.415 1.00 10.14 C

ATOM 3661 CD PRO B 105 -5.649 36.417 57.900 1.00 9.52 C

ATOM 3662 C PRO B 105 -8.114 34.176 56.687 1.00 9.31 C

ATOM 3663 O PRO B 105 -9.149 33.517 56.792 1.00 9.14 O

ATOM 3664 N PHE B 106 -7.414 34.246 55.553 1.00 9.17 N

ATOM 3665 CA PHE B 106 -7.811 33.484 54.362 1.00 9.52 C

ATOM 3666 CB PHE B 106 -6.977 33.890 53.147 1.00 9.21 C

ATOM 3667 CG PHE B 106 -7.414 35.178 52.499 1.00 9.23 C

ATOM 3668 CDl PHE B 106 -8.679 35.294 51.925 1.00 9.09 C

ATOM 3669 CEl PHE B 106 -9.077 36.490 51.300 1.00 8.52 C

ATOM 3670 CZ PHE B 106 -8.196 37.566 51.244 1.00 8.78 C

ATOM 3671 CE2 PHE B 106 -6.923 37.452 51.807 1.00 8.81 C

ATOM 3672 CD2 PHE B 106 -6.540 36.261 52.422 1.00 9.98 C

ATOM 3673 C PHE B 106 -7.658 31.983 54.596 1.00 9.68 C

ATOM 3674 O PHE B 106 -8.544 31.201 54.250 1.00 10.17 O

ATOM 3675 N THR B 107 -6.521 31.585 55.165 1.00 10.09 N

ATOM 3676 CA THR B 107 -6.268 30.174 55.453 1.00 10.14 C

ATOM 3677 CB THR B 107 -4.870 29.951 56.084 1.00 10.25 C

ATOM 3678 OGl THR B 107 -3.854 30.336 55.149 1.00 10.63 O

ATOM 3679 CG2 THR B 107 -4.661 28.492 56.448 1.00 10.33 C

ATOM 3680 C THR B 107 -7.370 29.618 56.354 1.00 9.98 C

ATOM 3681 O THR B 107 -7.943 28.566 56.060 1.00 10.24 O

ATOM 3682 N ALA B 108 -7.678 30.347 57.424 1.00 10.05 N

ATOM 3683 CA ALA B 108 -8.708 29.935 58.381 1.00 10.49 C

ATOM 3684 CB ALA B 108 -8.756 30.886 59.555 1.00 10.15 C

ATOM 3685 C ALA B 108 10.077 29.848 57.722 1.00 10.56 C

ATOM 3686 O ALA B 108 10.838 28.917 57.988 1.00 11.47 O

ATOM 3687 N MET B 109 10.371 30.816 56.857 1.00 10.75 N

ATOM 3688 CA MET B 109 11.666 30.906 56.197 1.00 10.91 C

ATOM 3689 CB MET B 109 11.835 32.285 55.547 1.00 10.88 C

ATOM 3690 CG MET B 109 13.176 32.521 54.867 1.00 11.03 C

ATOM 3691 SD MET B 109 13.207 31.985 53.146 1.00 10.66

ATOM 3692 CE MET B 109 12.180 33.254 52.386 1.00 10.32 C

ATOM 3693 C MET B 109 11.904 29.770 55.195 1.00 11.10 C

ATOM 3694 O MET B 109 13.016 29.250 55.105 1.00 10.97 O

ATOM 3695 N VAL B 110 10.871 29.380 54.451 1.00 11.34 N

ATOM 3696 CA VAL B 110 11.035 28.310 53.454 1.00 11.53 C

ATOM 3697 CB VAL B 110 10.080 28.461 52.225 1.00 11.50 C

ATOM 3698 CGl VAL B 110 10.301 29.799 51.527 1.00 11.51 C

ATOM 3699 CG2 VAL B 110 -8.605 28.264 52.624 1.00 11.37 C

ATOM 3700 C VAL B 110 10.914 26.905 54.053 1.00 11.64 C

ATOM 3701 O VAL B 110 11.268 25.922 53.399 1.00 11.81 O

ATOM 3702 N SER B 111 10.443 26.826 55.298 1.00 11.70 N

ATOM 3703 CA SER B 111 10.084 25.550 55.934 1.00 11.76 C

ATOM 3704 CB SER B 111 -9.398 25.791 57.282 1.00 11.92 C

ATOM 3705 OG SER B 111 10.295 26.358 58.218 1.00 11.43 O

ATOM 3706 C SER B 111 11.250 24.574 56.112 1.00 11.79 C

ATOM 3707 O SER B 111 11.036 23.357 56.173 1.00 12.11 O

ATOM 3708 N THR B 112 12.468 25.108 56.204 1.00 11.76 N

ATOM 3709 CA THR B 112 13.671 24.284 56.370 1.00 11.81 C W2025-7029WO / AM102903-PCT

ATOM 3710 CB THR B 112 14.184 24.305 57.830 1.00 11.91 C

ATOM 3711 OGl THR B 112 14.759 25.585 58.126 1.00 11.94 O

ATOM 3712 CG2 THR B 112 13.060 24.003 58.822 1.00 12.02 C

ATOM 3713 C THR B 112 14.781 24.784 55.442 1.00 11.93 C

ATOM 3714 O THR B 112 14.847 25.984 55.157 1.00 11.50 O

ATOM 3715 N PRO B 113 15.660 23.873 54.964 1.00 11.91 N

ATOM 3716 CA PRO B 113 16.797 24.339 54.162 1.00 12.11 C

ATOM 3717 CB PRO B 113 17.548 23.043 53.815 1.00 12.02 C

ATOM 3718 CG PRO B 113 17.075 22.035 54.806 1.00 12.36 C

ATOM 3719 CD PRO B 113 15.660 22.406 55.125 1.00 12.24 C

ATOM 3720 C PRO B 113 17.701 25.316 54.932 1.00 12.12 C

ATOM 3721 O PRO B 113 18.241 26.252 54.336 1.00 12.45 O

ATOM 3722 N GLU B 114 17.849 25.098 56.241 1.00 12.43 N

ATOM 3723 CA GLU B 114 18.592 26.006 57.121 1.00 12.64 C

ATOM 3724 CB GLU B 114 18.495 25.552 58.578 1.00 12.72 C

ATOM 3725 CG GLU B 114 19.398 24.381 58.934 1.00 13.49 C

ATOM 3726 CD GLU B 114 18.807 23.014 58.611 1.00 13.56 C

ATOM 3727 OEl GLU B 114 17.720 22.925 57.998 1.00 13.73 O

ATOM 3728 OE2 GLU B 114 19.449 22.014 58.986 1.00 13.80 O

ATOM 3729 C GLU B 114 18.094 27.446 57.014 1.00 12.46 C

ATOM 3730 O GLU B 114 18.887 28.370 56.816 1.00 12.71 O

ATOM 3731 N ASN B 115 16.781 27.626 57.143 1.00 12.37 N

ATOM 3732 CA ASN B 115 16.186 28.964 57.108 1.00 12.14 C

ATOM 3733 CB ASN B 115 14.731 28.932 57.585 1.00 12.01 C

ATOM 3734 CG ASN B 115 14.602 28.637 59.073 1.00 11.63 C

ATOM 3735 ODl ASN B 115 15.599 28.453 59.779 1.00 12.17 O

ATOM 3736 ND2 ASN B 115 13.366 28.599 59.558 1.00 11.55 N

ATOM 3737 C ASN B 115 16.307 29.620 55.737 1.00 11.98 C

ATOM 3738 O ASN B 115 16.553 30.829 55.641 1.00 12.27 O

ATOM 3739 N ARG B 116 16.159 28.822 54.678 1.00 11.75 N

ATOM 3740 CA ARG B 116 16.330 29.333 53.316 1.00 11.12 C

ATOM 3741 CB ARG B 116 15.918 28.295 52.259 1.00 11.16 C

ATOM 3742 CG ARG B 116 14.448 27.891 52.343 1.00 10.32 C

ATOM 3743 CD ARG B 116 13.953 27.229 51.069 1.00 10.71 C

ATOM 3744 NE ARG B 116 14.706 26.021 50.735 1.00 10.54 N

ATOM 3745 CZ ARG B 116 14.435 24.795 51.181 1.00 11.25 C

ATOM 3746 NHl ARG B 116 13.418 24.572 52.013 1.00 10.89 N

ATOM 3747 NH2 ARG B 116 15.198 23.778 50.793 1.00 10.64 N

ATOM 3748 C ARG B 116 17.763 29.805 53.083 1.00 11.56 C

ATOM 3749 O ARG B 116 17.979 30.837 52.451 1.00 11.15 O

ATOM 3750 N GLN B 117 18.737 29.061 53.612 1.00 11.83 N

ATOM 3751 CA GLN B 117 20.145 29.432 53.433 1.00 12.51 C

ATOM 3752 CB GLN B 117 21.097 28.282 53.806 1.00 13.14 C

ATOM 3753 CG GLN B 117 22.569 28.579 53.486 1.00 14.59 C

ATOM 3754 CD GLN B 117 22.807 28.881 52.012 1.00 17.07 C

ATOM 3755 OEl GLN B 117 23.066 30.026 51.632 1.00 19.50 O

ATOM 3756 NE2 GLN B 117 22.704 27.855 51.170 1.00 18.61 N

ATOM 3757 C GLN B 117 20.483 30.696 54.222 1.00 12.30 C

ATOM 3758 O GLN B 117 21.214 31.559 53.730 1.00 12.26 O

ATOM 3759 N THR B 118 19.952 30.790 55.440 1.00 12.35 N

ATOM 3760 CA THR B 118 20.103 31.981 56.278 1.00 12.59 C

ATOM 3761 CB THR B 118 19.362 31.804 57.628 1.00 12.57 C

ATOM 3762 OGl THR B 118 19.986 30.749 58.377 1.00 13.00 O

ATOM 3763 CG2 THR B 118 19.379 33.086 58.458 1.00 12.80 C

ATOM 3764 C THR B 118 19.578 33.202 55.520 1.00 12.47 C

ATOM 3765 O THR B 118 20.237 34.249 55.464 1.00 12.66 O

ATOM 3766 N PHE B 119 18.409 33.036 54.909 1.00 11.94 N

ATOM 3767 CA PHE B 119 17.782 34.099 54.131 1.00 11.84 C

ATOM 3768 CB PHE B 119 16.361 33.703 53.728 1.00 11.45 C

ATOM 3769 CG PHE B 119 15.636 34.777 52.965 1.00 10.64 C

ATOM 3770 CDl PHE B 119 15.233 35.946 53.604 1.00 10.31 C

ATOM 3771 CEl PHE B 119 14.575 36.952 52.901 1.00 10.06 C

ATOM 3772 CZ PHE B 119 14.310 36.794 51.545 1.00 10.59 C W2025-7029WO / AM102903-PCT

ATOM 3773 CE2 PHE B 119 14.715 35.631 50.891 1.00 9.79 C

ATOM 3774 CD2 PHE B 119 15.381 34.631 51.605 1.00 10.52 C

ATOM 3775 C PHE B 119 18.585 34.500 52.894 1.00 11.74 C

ATOM 3776 O PHE B 119 18.872 35.680 52.689 1.00 12.24 O

ATOM 3777 N ILE B 120 18.931 33.512 52.073 1.00 12.07 N

ATOM 3778 CA ILE B 120 19.670 33.733 50.833 1.00 12.34 C

ATOM 3779 CB ILE B 120 19.867 32.400 50.057 1.00 12.28 C

ATOM 3780 CGl ILE B 120 18.529 31.961 49.447 1.00 12.38 C

ATOM 3781 CDl ILE B 120 18.487 30.516 48.970 1.00 12.98 C

ATOM 3782 CG2 ILE B 120 20.930 32.544 48.978 1.00 12.59 C

ATOM 3783 C ILE B 120 21.005 34.451 51.079 1.00 12.56 C

ATOM 3784 O ILE B 120 21.337 35.422 50.394 1.00 12.51 O

ATOM 3785 N THR B 121 21.751 33.976 52.070 1.00 12.94 N

ATOM 3786 CA THR B 121 23.012 34.608 52.464 1.00 13.23 C

ATOM 3787 CB THR B 121 23.690 33.812 53.606 1.00 13.48 C

ATOM 3788 OGl THR B 121 23.981 32.493 53.138 1.00 13.81 O

ATOM 3789 CG2 THR B 121 24.989 34.479 54.056 1.00 13.59 C

ATOM 3790 C THR B 121 22.815 36.080 52.849 1.00 13.37 C

ATOM 3791 O THR B 121 23.553 36.957 52.377 1.00 13.25 O

ATOM 3792 N SER B 122 21.814 36.345 53.690 1.00 13.28 N

ATOM 3793 CA SER B 122 21.489 37.715 54.099 1.00 13.28 C

ATOM 3794 CB SER B 122 20.364 37.729 55.144 1.00 13.51 C

ATOM 3795 OG SER B 122 19.087 37.570 54.551 1.00 13.29 O

ATOM 3796 C SER B 122 21.119 38.586 52.891 1.00 13.31 C

ATOM 3797 O SER B 122 21.482 39.759 52.833 1.00 13.50 O

ATOM 3798 N VAL B 123 20.414 38.000 51.926 1.00 13.12 N

ATOM 3799 CA VAL B 123 19.990 38.735 50.729 1.00 13.55 C

ATOM 3800 CB VAL B 123 18.940 37.946 49.905 1.00 13.47 C

ATOM 3801 CGl VAL B 123 18.748 38.564 48.516 1.00 13.48 C

ATOM 3802 CG2 VAL B 123 17.623 37.914 50.650 1.00 13.43 C

ATOM 3803 C VAL B 123 21.173 39.159 49.861 1.00 13.44 C

ATOM 3804 O VAL B 123 21.245 40.303 49.424 1.00 13.42 O

ATOM 3805 N ILE B 124 22.101 38.236 49.624 1.00 13.90 N

ATOM 3806 CA ILE B 124 23.287 38.540 48.831 1.00 14.21 C

ATOM 3807 CB ILE B 124 24.197 37.298 48.659 1.00 14.10 C

ATOM 3808 CGl ILE B 124 23.505 36.243 47.779 1.00 13.82 C

ATOM 3809 CDl ILE B 124 24.250 34.920 47.676 1.00 14.10 C

ATOM 3810 CG2 ILE B 124 25.544 37.704 48.056 1.00 14.50 C

ATOM 3811 C ILE B 124 24.063 39.694 49.471 1.00 14.54 C

ATOM 3812 O ILE B 124 24.434 40.659 48.789 1.00 14.74 O

ATOM 3813 N LYS B 125 24.286 39.588 50.780 1.00 14.97 N

ATOM 3814 CA LYS B 125 25.007 40.603 51.545 1.00 15.07 C

ATOM 3815 CB LYS B 125 25.176 40.140 52.998 1.00 15.29 C

ATOM 3816 CG LYS B 125 25.749 41.192 53.961 1.00 16.75 C

ATOM 3817 CD LYS B 125 26.457 40.563 55.165 1.00 19.40 C

ATOM 3818 CE LYS B 125 25.625 39.485 55.868 1.00 22.13 C

ATOM 3819 NZ LYS B 125 24.446 40.002 56.640 1.00 23.13 N

ATOM 3820 C LYS B 125 24.294 41.957 51.474 1.00 14.69 C

ATOM 3821 O LYS B 125 24.917 42.978 51.186 1.00 14.70 O

ATOM 3822 N PHE B 126 22.987 41.945 51.725 1.00 14.20 N

ATOM 3823 CA PHE B 126 22.154 43.153 51.741 1.00 13.94 C

ATOM 3824 CB PHE B 126 20.721 42.756 52.101 1.00 13.84 C

ATOM 3825 CG PHE B 126 19.926 43.828 52.796 1.00 13.16 C

ATOM 3826 CDl PHE B 126 19.074 44.658 52.076 1.00 12.51 C

ATOM 3827 CEl PHE B 126 18.315 45.632 52.722 1.00 12.97 C

ATOM 3828 CZ PHE B 126 18.393 45.774 54.104 1.00 13.07 C

ATOM 3829 CE2 PHE B 126 19.226 44.939 54.836 1.00 13.41 C

ATOM 3830 CD2 PHE B 126 19.984 43.969 54.181 1.00 13.12 C

ATOM 3831 C PHE B 126 22.177 43.883 50.394 1.00 13.93 C

ATOM 3832 O PHE B 126 22.466 45.084 50.334 1.00 13.79 O

ATOM 3833 N LEU B 127 21.889 43.155 49.312 1.00 13.76 N

ATOM 3834 CA LEU B 127 21.801 43.757 47.977 1.00 13.79 C

ATOM 3835 CB LEU B 127 21.263 42.755 46.945 1.00 13.77 C W2025-7029WO / AM102903-PCT

ATOM 3836 CG LEU B 127 19.866 42.155 47.158 1.00 13.65 C

ATOM 3837 CDl LEU B 127 19.508 41.272 45.971 1.00 13.89 C

ATOM 3838 CD2 LEU B 127 18.797 43.223 47.381 1.00 13.18 C

ATOM 3839 C LEU B 127 23.131 44.348 47.502 1.00 13.90 C

ATOM 3840 O LEU B 127 23.158 45.433 46.921 1.00 13.51 O

ATOM 3841 N ARG B 128 24.218 43.621 47.741 1.00 13.99 N

ATOM 3842 CA ARG B 128 25.533 44.113 47.364 1.00 14.46 C

ATOM 3843 CB ARG B 128 26.573 42.993 47.480 1.00 14.31 C

ATOM 3844 CG ARG B 128 26.436 41.886 46.445 1.00 14.56 C

ATOM 3845 CD ARG B 128 26.498 42.399 45.046 1.00 15.03 C

ATOM 3846 NE ARG B 128 26.617 41.331 44.072 1.00 16.46 N

ATOM 3847 CZ ARG B 128 26.468 41.486 42.767 1.00 16.84 C

ATOM 3848 NHl ARG B 128 26.137 42.658 42.273 1.00 17.77 N

ATOM 3849 NH2 ARG B 128 26.594 40.461 41.963 1.00 17.57 N

ATOM 3850 C ARG B 128 25.956 45.313 48.228 1.00 14.66 C

ATOM 3851 O ARG B 128 26.573 46.234 47.757 1.00 14.82 O

ATOM 3852 N GLN B 129 25.603 45.265 49.504 1.00 17.71 N

ATOM 3853 CA GLN B 129 25.990 46.340 50.404 1.00 17.86 C

ATOM 3854 CB GLN B 129 25.651 45.968 51.829 1.00 18.16 C

ATOM 3855 CG GLN B 129 25.903 47.034 52.781 1.00 19.20 C

ATOM 3856 CD GLN B 129 25.619 46.639 54.205 1.00 20.59 C

ATOM 3857 OEl GLN B 129 25.063 45.565 54.511 1.00 21.25 O

ATOM 3858 NE2 GLN B 129 26.006 47.512 55.095 1.00 21.44 N

ATOM 3859 C GLN B 129 25.328 47.682 50.043 1.00 17.72 C

ATOM 3860 O GLN B 129 25.966 48.704 50.071 1.00 14.96 O

ATOM 3861 N TYR B 130 24.036 47.635 49.733 1.00 14.81 N

ATOM 3862 CA TYR B 130 23.261 48.833 49.446 1.00 14.67 C

ATOM 3863 CB TYR B 130 21.918 48.790 50.178 1.00 14.68 C

ATOM 3864 CG TYR B 130 22.050 48.685 51.683 1.00 14.55 C

ATOM 3865 CDl TYR B 130 22.695 49.664 52.406 1.00 14.63 C

ATOM 3866 CEl TYR B 130 22.810 49.587 53.754 1.00 15.70 C

ATOM 3867 CZ TYR B 130 22.265 48.531 54.440 1.00 15.97 C

ATOM 3868 OH TYR B 130 22.381 48.490 55.802 1.00 17.60 O

ATOM 3869 CE2 TYR B 130 21.607 47.539 53.758 1.00 15.37 C

ATOM 3870 CD2 TYR B 130 21.497 47.621 52.387 1.00 15.09 C

ATOM 3871 C TYR B 130 23.110 49.150 47.953 1.00 14.64 C

ATOM 3872 O TYR B 130 22.435 50.093 47.574 1.00 14.73 O

ATOM 3873 N GLU B 131 23.764 48.340 47.137 1.00 14.23 N

ATOM 3874 CA GLU B 131 23.894 48.566 45.689 1.00 14.44 C

ATOM 3875 CB GLU B 131 24.580 49.916 45.390 1.00 14.96 C

ATOM 3876 CG GLU B 131 25.964 50.032 46.045 1.00 17.10 C

ATOM 3877 CD GLU B 131 26.718 51.280 45.634 1.00 19.53 C

ATOM 3878 OEl GLU B 131 27.649 51.157 44.816 1.00 22.99 O

ATOM 3879 OE2 GLU B 131 26.383 52.378 46.122 1.00 21.74 O

ATOM 3880 C GLU B 131 22.600 48.350 44.886 1.00 13.87 C

ATOM 3881 O GLU B 131 22.282 49.115 43.965 1.00 13.72 O

ATOM 3882 N PHE B 132 21.858 47.304 45.249 1.00 13.00 N

ATOM 3883 CA PHE B 132 20.715 46.849 44.456 1.00 12.31 C

ATOM 3884 CB PHE B 132 19.639 46.238 45.351 1.00 11.71 C

ATOM 3885 CG PHE B 132 18.839 47.248 46.115 1.00 10.43 C

ATOM 3886 CDl PHE B 132 17.849 47.991 45.485 1.00 10.17 C

ATOM 3887 CEl PHE B 132 17.087 48.924 46.201 1.00 10.72 C

ATOM 3888 CZ PHE B 132 17.319 49.112 47.559 1.00 10.05 C

ATOM 3889 CE2 PHE B 132 18.308 48.364 48.202 1.00 9.95 C

ATOM 3890 CD2 PHE B 132 19.058 47.438 47.477 1.00 10.26 C

ATOM 3891 C PHE B 132 21.175 45.809 43.446 1.00 12.34 C

ATOM 3892 O PHE B 132 22.129 45.068 43.709 1.00 12.90 O

ATOM 3893 N ASP B 133 20.495 45.756 42.301 1.00 12.13 N

ATOM 3894 CA ASP B 133 20.823 44.803 41.236 1.00 12.03 C

ATOM 3895 CB ASP B 133 20.613 45.445 39.861 1.00 12.34 C

ATOM 3896 CG ASP B 133 21.456 46.685 39.667 1.00 12.97 C

ATOM 3897 ODl ASP B 133 22.695 46.552 39.595 1.00 14.39 O

ATOM 3898 OD2 ASP B 133 20.880 47.786 39.593 1.00 13.97 O W2025-7029WO / AM102903-PCT

ATOM 3899 C ASP B 133 20.022 43.501 41.318 1.00 11.69 C

ATOM 3900 O ASP B 133 20.250 42.580 40.531 1.00 11.59 O

ATOM 3901 N GLY B 134 19.088 43.425 42.262 1.00 11.33 N

ATOM 3902 CA GLY B 134 18.264 42.225 42.396 1.00 10.70 C

ATOM 3903 C GLY B 134 17.243 42.256 43.511 1.00 10.64 C

ATOM 3904 O GLY B 134 17.088 43.266 44.203 1.00 10.70 O

ATOM 3905 N LEU B 135 16.551 41.129 43.680 1.00 10.21 N

ATOM 3906 CA LEU B 135 15.462 40.996 44.647 1.00 10.04 C

ATOM 3907 CB LEU B 135 15.757 39.873 45.656 1.00 9.96 C

ATOM 3908 CG LEU B 135 14.751 39.695 46.813 1.00 9.95 C

ATOM 3909 CDl LEU B 135 14.972 40.745 47.882 1.00 10.69 C

ATOM 3910 CD2 LEU B 135 14.853 38.306 47.438 1.00 10.23 C

ATOM 3911 C LEU B 135 14.161 40.683 43.917 1.00 9.66 C

ATOM 3912 O LEU B 135 14.128 39.821 43.037 1.00 10.06 O

ATOM 3913 N ASP B 136 13.100 41.399 44.283 1.00 9.32 N

ATOM 3914 CA ASP B 136 11.754 41.121 43.801 1.00 8.94 C

ATOM 3915 CB ASP B 136 11.098 42.429 43.342 1.00 9.08 C

ATOM 3916 CG ASP B 136 -9.755 42.226 42.657 1.00 9.13 C

ATOM 3917 ODl ASP B 136 -9.614 41.321 41.795 1.00 9.24 O

ATOM 3918 OD2 ASP B 136 -8.838 43.021 42.967 1.00 10.28 O

ATOM 3919 C ASP B 136 10.971 40.495 44.954 1.00 8.71 C

ATOM 3920 O ASP B 136 10.724 41.150 45.964 1.00 8.51 O

ATOM 3921 N PHE B 137 10.602 39.224 44.813 1.00 8.43 N

ATOM 3922 CA PHE B 137 -9.766 38.554 45.813 1.00 8.75 C

ATOM 3923 CB PHE B 137 -9.759 37.041 45.591 1.00 8.54 C

ATOM 3924 CG PHE B 137 10.948 36.336 46.159 1.00 8.78 C

ATOM 3925 CDl PHE B 137 11.907 35.781 45.318 1.00 9.28 C

ATOM 3926 CEl PHE B 137 13.016 35.109 45.849 1.00 8.92 C

ATOM 3927 CZ PHE B 137 13.167 34.996 47.229 1.00 9.23 C

ATOM 3928 CE2 PHE B 137 12.214 35.544 48.075 1.00 9.45 C

ATOM 3929 CD2 PHE B 137 11.107 36.213 47.536 1.00 8.85 C

ATOM 3930 C PHE B 137 -8.329 39.053 45.727 1.00 8.94 C

ATOM 3931 O PHE B 137 -7.723 39.007 44.657 1.00 9.52 O

ATOM 3932 N ASP B 138 -7.778 39.496 46.854 1.00 9.09 N

ATOM 3933 CA ASP B 138 -6.365 39.857 46.910 1.00 9.20 C

ATOM 3934 CB ASP B 138 -6.179 41.372 46.980 1.00 9.28 C

ATOM 3935 CG ASP B 138 -4.734 41.791 46.790 1.00 9.35 C

ATOM 3936 ODl ASP B 138 -3.928 40.969 46.293 1.00 9.84 O

ATOM 3937 OD2 ASP B 138 -4.409 42.942 47.144 1.00 9.93 O

ATOM 3938 C ASP B 138 -5.656 39.139 48.057 1.00 9.31 C

ATOM 3939 O ASP B 138 -5.144 39.752 49.001 1.00 9.34 O

ATOM 3940 N TRP B 139 -5.648 37.816 47.954 1.00 9.27 N

ATOM 3941 CA TRP B 139 -4.957 36.954 48.889 1.00 9.01 C

ATOM 3942 CB TRP B 139 -5.641 35.585 48.870 1.00 9.07 C

ATOM 3943 CG TRP B 139 -5.053 34.519 49.744 1.00 9.26 C

ATOM 3944 CDl TRP B 139 -3.851 34.533 50.392 1.00 9.09 C

ATOM 3945 NEl TRP B 139 -3.667 33.351 51.073 1.00 9.03 N

ATOM 3946 CE2 TRP B 139 -4.753 32.544 50.859 1.00 8.99 C

ATOM 3947 CD2 TRP B 139 -5.645 33.249 50.022 1.00 8.93 C

ATOM 3948 CE3 TRP B 139 -6.849 32.636 49.641 1.00 10.04 C

ATOM 3949 CZ3 TRP B 139 -7.122 31.353 50.106 1.00 8.91 C

ATOM 3950 CH2 TRP B 139 -6.215 30.679 50.944 1.00 9.48 C

ATOM 3951 CZ2 TRP B 139 -5.028 31.254 51.328 1.00 8.66 C

ATOM 3952 C TRP B 139 -3.516 36.839 48.424 1.00 8.91 C

ATOM 3953 O TRP B 139 -3.246 36.295 47.354 1.00 8.67 O

ATOM 3954 N GLU B 140 -2.594 37.344 49.235 1.00 8.82 N

ATOM 3955 CA GLU B 140 -1.182 37.318 48.882 1.00 9.32 C

ATOM 3956 CB GLU B 140 -0.636 38.753 48.752 1.00 8.96 C

ATOM 3957 CG GLU B 140 -1.497 39.632 47.834 1.00 8.88 C

ATOM 3958 CD GLU B 140 -0.872 40.965 47.456 1.00 9.42 C

ATOM 3959 OEl GLU B 140 0.268 41.261 47.872 1.00 8.23 O

ATOM 3960 OE2 GLU B 140 -1.540 41.726 46.723 1.00 8.91 O

ATOM 3961 C GLU B 140 -0.379 36.494 49.888 1.00 9.35 C W2025-7029WO / AM102903-PCT

ATOM 3962 O GLU B 140 0.052 37.027 50.920 1.00 9.76 O

ATOM 3963 N TYR B 141 0.185 35.196 49.627 1.00 9.47 N

ATOM 3964 CA TYR B 141 0.765 34.441 48.504 1.00 9.32 C

ATOM 3965 CB TYR B 141 0.255 34.252 47.369 1.00 9.42 C

ATOM 3966 CG TYR B 141 0.928 35.513 46.890 1.00 10.08 C

ATOM 3967 CDl TYR B 141 2.182 35.876 47.377 1.00 11.45 C

ATOM 3968 CEl TYR B 141 2.816 37.032 46.946 1.00 11.33 C

ATOM 3969 CZ TYR B 141 2.196 37.843 46.010 1.00 11.76 C

ATOM 3970 OH TYR B 141 2.831 38.987 45.586 1.00 12.83 O

ATOM 3971 CE2 TYR B 141 0.949 37.510 45.504 1.00 12.22 C

ATOM 3972 CD2 TYR B 141 0.320 36.339 45.942 1.00 11.17 C

ATOM 3973 C TYR B 141 1.141 33.047 49.018 1.00 8.69 C

ATOM 3974 O TYR B 141 0.592 32.603 50.028 1.00 8.92 O

ATOM 3975 N PRO B 142 2.038 32.330 48.309 1.00 8.58 N

ATOM 3976 CA PRO B 142 2.259 30.934 48.703 1.00 8.59 C

ATOM 3977 CB PRO B 142 3.279 30.419 47.672 1.00 8.50 C

ATOM 3978 CG PRO B 142 3.885 31.651 47.064 1.00 8.35 C

ATOM 3979 CD PRO B 142 2.837 32.713 47.127 1.00 8.37 C

ATOM 3980 C PRO B 142 0.946 30.164 48.568 1.00 9.08 C

ATOM 3981 O PRO B 142 0.204 30.381 47.604 1.00 8.92 O

ATOM 3982 N GLY B 143 0.633 29.315 49.543 1.00 9.46 N

ATOM 3983 CA GLY B 143 0.576 28.499 49.479 1.00 10.39 C

ATOM 3984 C GLY B 143 1.912 29.170 49.776 1.00 10.99 C

ATOM 3985 O GLY B 143 2.955 28.515 49.698 1.00 11.17 O

ATOM 3986 N SER B 144 1.899 30.461 50.104 1.00 11.10 N

ATOM 3987 CA SER B 144 3.117 31.147 50.561 1.00 11.72 C

ATOM 3988 CB SER B 144 3.868 31.794 49.385 1.00 11.95 C

ATOM 3989 OG SER B 144 3.113 32.819 48.782 1.00 13.71 O

ATOM 3990 C SER B 144 2.817 32.147 51.683 1.00 11.73 C

ATOM 3991 O SER B 144 1.662 32.298 52.091 1.00 11.77 O

ATOM 3992 N ARG B 145 3.860 32.798 52.204 1.00 11.63 N

ATOM 3993 CA ARG B 145 3.709 33.752 53.313 1.00 11.78 C

ATOM 3994 CB ARG B 145 3.103 35.072 52.811 1.00 11.62 C

ATOM 3995 CG ARG B 145 3.896 35.730 51.685 1.00 11.74 C

ATOM 3996 CD ARG B 145 3.304 37.071 51.326 1.00 11.18 C

ATOM 3997 NE ARG B 145 3.593 38.115 52.308 1.00 11.58 N

ATOM 3998 C Z ARG B 145 2.723 39.051 52.691 1.00 11.42 C

ATOM 3999 NHl ARG B 145 3.087 39.972 53.577 1.00 11.23 N

ATOM 4000 NH2 ARG B 145 1.482 39.066 52.199 1.00 11.17 N

ATOM 4001 C ARG B 145 2.881 33.178 54.472 1.00 11.92 C

ATOM 4002 O ARG B 145 1.998 33.849 55.012 1.00 12.57 O

ATOM 4003 N GLY B 146 3.164 31.927 54.832 1.00 12.00 N

ATOM 4004 CA GLY B 146 2.504 31.269 55.957 1.00 11.72 C

ATOM 4005 C GLY B 146 1.335 30.378 55.587 1.00 11.33 C

ATOM 4006 O GLY B 146 0.917 29.534 56.385 1.00 11.98 O

ATOM 4007 N SER B 147 0.791 30.577 54.387 1.00 11.05 N

ATOM 4008 CA SER B 147 0.317 29.761 53.886 1.00 10.68 C

ATOM 4009 CB SER B 147 0.992 30.460 52.697 1.00 10.54 C

ATOM 4010 OG SER B 147 1.877 29.587 52.015 1.00 10.05 O

ATOM 4011 C SER B 147 0.181 28.361 53.489 1.00 10.73 C

ATOM 4012 O SER B 147 1.109 28.236 52.682 1.00 10.15 O

ATOM 4013 N PRO B 148 0.428 27.303 54.064 1.00 10.94 N

ATOM 4014 CA PRO B 148 0.010 25.924 53.832 1.00 11.03 C

ATOM 4015 CB PRO B 148 0.759 25.136 54.897 1.00 10.99 C

ATOM 4016 CG PRO B 148 1.996 25.927 55.118 1.00 11.59 C

ATOM 4017 CD PRO B 148 1.578 27.360 54.988 1.00 10.75 C

ATOM 4018 C PRO B 148 0.334 25.422 52.427 1.00 11.30 C

ATOM 4019 O PRO B 148 1.196 26.005 51.769 1.00 11.26 O

ATOM 4020 N PRO B 149 0.327 24.336 51.976 1.00 11.62 N

ATOM 4021 CA PRO B 149 0.191 23.817 50.608 1.00 11.76 C

ATOM 4022 CB PRO B 149 0.983 22.505 50.647 1.00 11.89 C

ATOM 4023 CG PRO B 149 1.927 22.646 51.777 1.00 12.45 C

ATOM 4024 CD PRO B 149 1.261 23.526 52.783 1.00 11.97 C W2025-7029WO / AM102903-PCT

ATOM 4025 C PRO B 149 -1.247 23.537 50.156 1.00 11.70 C

ATOM 4026 O PRO B 149 -1.546 23.686 48.966 1.00 11.77 O

ATOM 4027 N GLN B 150 -2.117 23.129 51.084 1.00 11.15 N

ATOM 4028 CA GLN B 150 -3.505 22.785 50.739 1.00 11.12 C

ATOM 4029 CB GLN B 150 -4.222 22.047 51.888 1.00 11.27 C

ATOM 4030 CG GLN B 150 -4.441 22.855 53.168 1.00 12.13 C

ATOM 4031 CD GLN B 150 -3.315 22.695 54.176 1.00 11.90 C

ATOM 4032 OEl GLN B 150 -2.182 22.365 53.823 1.00 13.27 O

ATOM 4033 NE2 GLN B 150 -3.626 22.938 55.441 1.00 12.83 N

ATOM 4034 C GLN B 150 -4.332 23.985 50.261 1.00 10.70 C

ATOM 4035 O GLN B 150 -5.349 23.811 49.584 1.00 10.40 O

ATOM 4036 N ASP B 151 -3.874 25.194 50.600 1.00 10.39 N

ATOM 4037 CA ASP B 151 -4.551 26.430 50.196 1.00 10.35 C

ATOM 4038 CB ASP B 151 -3.983 27.625 50.959 1.00 10.13 C

ATOM 4039 CG ASP B 151 -4.464 27.683 52.401 1.00 10.82 C

ATOM 4040 ODl ASP B 151 -5.268 26.810 52.819 1.00 10.96 O

ATOM 4041 OD2 ASP B 151 -4.040 28.613 53.113 1.00 10.13 O

ATOM 4042 C ASP B 151 -4.530 26.705 48.691 1.00 10.26 C

ATOM 4043 O ASP B 151 -5.381 27.433 48.186 1.00 10.22 O

ATOM 4044 N LYS B 152 -3.556 26.139 47.979 1.00 10.35 N

ATOM 4045 CA LYS B 152 -3.537 26.242 46.519 1.00 10.36 C

ATOM 4046 CB LYS B 152 -2.312 25.526 45.938 1.00 10.55 C

ATOM 4047 CG LYS B 152 -2.271 25.460 44.412 1.00 11.19 C

ATOM 4048 CD LYS B 152 -1.001 24.780 43.924 1.00 11.87 C

ATOM 4049 CE LYS B 152 -1.058 24.542 42.421 1.00 12.71 C

ATOM 4050 NZ LYS B 152 0.206 23.954 41.889 1.00 13.88 N

ATOM 4051 C LYS B 152 -4.846 25.679 45.943 1.00 10.35 C

ATOM 4052 O LYS B 152 -5.530 26.353 45.173 1.00 9.67 O

ATOM 4053 N HIS B 153 -5.207 24.460 46.345 1.00 10.34 N

ATOM 4054 CA HIS B 153 -6.472 23.873 45.898 1.00 10.85 C

ATOM 4055 CB HIS B 153 -6.512 22.359 46.113 1.00 11.06 C

ATOM 4056 CG HIS B 153 -7.814 21.735 45.713 1.00 11.52 C

ATOM 4057 NDl HIS B 153 -8.271 21.737 44.413 1.00 12.60 N

ATOM 4058 CEl HIS B 153 -9.441 21.124 44.358 1.00 13.13 C

ATOM 4059 NE2 HIS B 153 -9.761 20.730 45.578 1.00 12.30 N

ATOM 4060 CD2 HIS B 153 -8.762 21.101 46.445 1.00 12.29 C

ATOM 4061 C HIS B 153 -7.680 24.518 46.571 1.00 10.61 C

ATOM 4062 O HIS B 153 -8.712 24.730 45.926 1.00 10.66 O

ATOM 4063 N LEU B 154 -7.559 24.819 47.861 1.00 10.53 N

ATOM 4064 CA LEU B 154 -8.681 25.410 48.597 1.00 10.58 C

ATOM 4065 CB LEU B 154 -8.410 25.456 50.107 1.00 10.97 C

ATOM 4066 CG LEU B 154 -8.494 24.099 50.827 1.00 11.48 C

ATOM 4067 CDl LEU B 154 -8.011 24.222 52.265 1.00 12.28 C

ATOM 4068 CD2 LEU B 154 -9.909 23.489 50.775 1.00 12.73 C

ATOM 4069 C LEU B 154 -9.094 26.779 48.057 1.00 10.29 C

ATOM 4070 O LEU B 154 10.267 27.152 48.146 1.00 10.27 O

ATOM 4071 N PHE B 155 -8.136 27.514 47.492 1.00 10.07 N

ATOM 4072 CA PHE B 155 -8.449 28.770 46.816 1.00 9.96 C

ATOM 4073 CB PHE B 155 -7.181 29.513 46.393 1.00 9.97 C

ATOM 4074 CG PHE B 155 -7.442 30.871 45.803 1.00 8.90 C

ATOM 4075 CDl PHE B 155 -8.245 31.802 46.470 1.00 9.49 C

ATOM 4076 CEl PHE B 155 -8.488 33.062 45.919 1.00 9.31 C

ATOM 4077 CZ PHE B 155 -7.917 33.403 44.694 1.00 10.14 C

ATOM 4078 CE2 PHE B 155 -7.117 32.483 44.023 1.00 9.56 C

ATOM 4079 CD2 PHE B 155 -6.880 31.224 44.586 1.00 9.50 C

ATOM 4080 C PHE B 155 -9.354 28.514 45.615 1.00 9.98 C

ATOM 4081 O PHE B 155 10.350 29.208 45.431 1.00 10.00 O

ATOM 4082 N THR B 156 -9.015 27.511 44.808 1.00 9.98 N

ATOM 4083 CA THR B 156 -9.872 27.109 43.690 1.00 10.23 C

ATOM 4084 CB THR B 156 -9.292 25.887 42.956 1.00 10.26 C

ATOM 4085 OGl THR B 156 -7.922 26.143 42.615 1.00 10.88 O

ATOM 4086 CG2 THR B 156 10.095 25.579 41.687 1.00 10.72 C

ATOM 4087 C THR B 156 11.291 26.780 44.162 1.00 10.33 C W2025-7029WO / AM102903-PCT

ATOM 4088 O THR B 156 12.275 27.227 43.563 1.00 10.21 O

ATOM 4089 N VAL B 157 11.383 25.997 45.233 1.00 10.39 N

ATOM 4090 CA VAL B 157 12.671 25.600 45.801 1.00 10.68 C

ATOM 4091 CB VAL B 157 12.487 24.637 46.994 1.00 10.83 C

ATOM 4092 CGl VAL B 157 13.834 24.281 47.614 1.00 10.72 C

ATOM 4093 CG2 VAL B 157 11.757 23.375 46.546 1.00 11.05 C

ATOM 4094 C VAL B 157 13.490 26.830 46.218 1.00 10.72 C

ATOM 4095 O VAL B 157 14.663 26.956 45.858 1.00 10.51 O

ATOM 4096 N LEU B 158 12.856 27.740 46.954 1.00 10.89 N

ATOM 4097 CA LEU B 158 13.495 28.985 47.389 1.00 11.07 C

ATOM 4098 CB LEU B 158 12.491 29.855 48.157 1.00 11.32 C

ATOM 4099 CG LEU B 158 12.891 31.302 48.465 1.00 11.66 C

ATOM 4100 CDl LEU B 158 14.003 31.338 49.517 1.00 13.42 C

ATOM 4101 CD2 LEU B 158 11.667 32.094 48.933 1.00 12.15 C

ATOM 4102 C LEU B 158 14.072 29.771 46.209 1.00 11.08 C

ATOM 4103 O LEU B 158 15.233 30.194 46.229 1.00 11.04 O

ATOM 4104 N VAL B 159 13.251 29.963 45.182 1.00 11.00 N

ATOM 4105 CA VAL B 159 13.650 30.732 44.010 1.00 11.37 C

ATOM 4106 CB VAL B 159 12.436 31.008 43.076 1.00 11.22 C

ATOM 4107 CGl VAL B 159 12.876 31.641 41.770 1.00 10.86 C

ATOM 4108 CG2 VAL B 159 11.424 31.916 43.778 1.00 10.85 C

ATOM 4109 C VAL B 159 14.796 30.036 43.267 1.00 11.87 C

ATOM 4110 O VAL B 159 15.764 30.689 42.872 1.00 11.89 O

ATOM 4111 N GLN B 160 14.690 28.718 43.097 1.00 12.47 N

ATOM 4112 CA GLN B 160 15.765 27.936 42.482 1.00 12.93 C

ATOM 4113 CB GLN B 160 15.399 26.451 42.389 1.00 13.38 C

ATOM 4114 CG GLN B 160 16.510 25.622 41.730 1.00 15.34 C

ATOM 4115 CD GLN B 160 16.212 24.139 41.657 1.00 18.57 C

ATOM 4116 OEl GLN B 160 15.367 23.617 42.388 1.00 20.44 O

ATOM 4117 NE2 GLN B 160 16.928 23.441 40.781 1.00 20.76 N

ATOM 4118 C GLN B 160 17.080 28.097 43.242 1.00 12.86 C

ATOM 4119 O GLN B 160 18.119 28.392 42.645 1.00 12.52 O

ATOM 4120 N GLU B 161 17.024 27.909 44.558 1.00 12.84 N

ATOM 4121 CA GLU B 161 18.215 28.032 45.403 1.00 13.06 C

ATOM 4122 CB GLU B 161 17.911 27.596 46.837 1.00 13.08 C

ATOM 4123 CG GLU B 161 17.656 26.095 46.974 1.00 12.90 C

ATOM 4124 CD GLU B 161 17.222 25.673 48.369 1.00 12.54 C

ATOM 4125 OEl GLU B 161 16.980 26.551 49.232 1.00 13.27 O

ATOM 4126 OE2 GLU B 161 17.113 24.447 48.597 1.00 12.68 O

ATOM 4127 C GLU B 161 18.804 29.446 45.361 1.00 13.33 C

ATOM 4128 O GLU B 161 20.027 29.603 45.322 1.00 13.36 O

ATOM 4129 N MET B 162 17.938 30.463 45.350 1.00 13.24 N

ATOM 4130 CA AMET B 162 18.395 31.844 45.251 0.50 13.36 C

ATOM 4131 CA BMET B 162 18.379 31.857 45.252 0.50 13.62 C

ATOM 4132 CB AMET B 162 17.247 32.825 45.467 0.50 13.20 C

ATOM 4133 CB BMET B 162 17.196 32.819 45.450 0.50 13.60 C

ATOM 4134 CG AMET B 162 17.670 34.268 45.270 0.50 12.93 C

ATOM 4135 CG BMET B 162 17.568 34.308 45.508 0.50 14.20 C

ATOM 4136 SD AMET B 162 16.545 35.450 45.998 0.50 12.02

ATOM 4137 SD BMET B 162 18.296 34.862 47.070 0.50 16.03 S

ATOM 4138 CE AMET B 162 16.899 35.243 47.746 0.50 12.27 C

ATOM 4139 CE BMET B 162 16.840 35.023 48.102 0.50 15.41 C

ATOM 4140 C MET B 162 19.069 32.108 43.906 1.00 13.61 C

ATOM 4141 O MET B 162 20.179 32.643 43.861 1.00 13.65 O

ATOM 4142 N ARG B 163 18.403 31.717 42.819 1.00 13.98 N

ATOM 4143 CA ARG B 163 18.950 31.875 41.471 1.00 14.65 C

ATOM 4144 CB ARG B 163 17.981 31.310 40.421 1.00 14.72 C

ATOM 4145 CG ARG B 163 18.540 31.174 38.997 1.00 15.41 C

ATOM 4146 CD ARG B 163 18.766 32.511 38.296 1.00 16.25 C

ATOM 4147 NE ARG B 163 19.268 32.296 36.938 1.00 16.55 N

ATOM 4148 CZ ARG B 163 18.521 32.306 35.835 1.00 17.13 C

ATOM 4149 NHl ARG B 163 19.087 32.082 34.654 1.00 17.16 N

ATOM 4150 NH2 ARG B 163 17.215 32.552 35.898 1.00 16.12 N W2025-7029WO / AM102903-PCT

ATOM 4151 C ARG B 163 20.322 31.211 41.368 1.00 15.26 C

ATOM 4152 O ARG B 163 21.278 31.818 40.879 1.00 15.37 O

ATOM 4153 N GLU B 164 20.414 29.973 41.849 1.00 15.68 N

ATOM 4154 CA GLU B 164 21.671 29.230 41.826 1.00 16.68 C

ATOM 4155 CB GLU B 164 21.439 27.758 42.182 1.00 16.80 C

ATOM 4156 CG GLU B 164 20.759 26.979 41.054 1.00 18.54 C

ATOM 4157 CD GLU B 164 20.221 25.622 41.480 1.00 20.53 C

ATOM 4158 OEl GLU B 164 19.778 24.866 40.589 1.00 21.67 O

ATOM 4159 OE2 GLU B 164 20.225 25.310 42.692 1.00 23.53 O

ATOM 4160 C GLU B 164 22.737 29.872 42.719 1.00 16.64 C

ATOM 4161 O GLU B 164 23.915 29.899 42.357 1.00 16.95 O

ATOM 4162 N ALA B 165 22.318 30.409 43.866 1.00 16.62 N

ATOM 4163 CA ALA B 165 23.233 31.113 44.766 1.00 16.67 C

ATOM 4164 CB ALA B 165 22.566 31.390 46.099 1.00 16.54 C

ATOM 4165 C ALA B 165 23.752 32.411 44.147 1.00 16.85 C

ATOM 4166 O ALA B 165 24.908 32.791 44.364 1.00 16.63 O

ATOM 4167 N PHE B 166 22.889 33.084 43.383 1.00 16.74 N

ATOM 4168 CA PHE B 166 23.260 34.296 42.663 1.00 17.39 C

ATOM 4169 CB PHE B 166 22.025 34.979 42.063 1.00 16.83 C

ATOM 4170 CG PHE B 166 21.202 35.763 43.060 1.00 15.76 C

ATOM 4171 CDl PHE B 166 21.622 35.927 44.377 1.00 14.50 C

ATOM 4172 CEl PHE B 166 20.865 36.658 45.287 1.00 15.36 C

ATOM 4173 CZ PHE B 166 19.680 37.262 44.877 1.00 14.92 C

ATOM 4174 CE2 PHE B 166 19.253 37.119 43.562 1.00 14.23 C

ATOM 4175 CD2 PHE B 166 20.015 36.374 42.660 1.00 15.22 C

ATOM 4176 C PHE B 166 24.282 33.989 41.569 1.00 18.19 C

ATOM 4177 O PHE B 166 25.246 34.739 41.380 1.00 18.08 O

ATOM 4178 N GLU B 167 24.066 32.879 40.864 1.00 19.29 N

ATOM 4179 CA GLU B 167 24.998 32.414 39.833 1.00 20.67 C

ATOM 4180 CB GLU B 167 24.425 31.205 39.084 1.00 20.65 C

ATOM 4181 CG GLU B 167 23.247 31.549 38.168 1.00 21.61 C

ATOM 4182 CD GLU B 167 22.476 30.328 37.670 1.00 23.36 C

ATOM 4183 OEl GLU B 167 22.778 29.189 38.092 1.00 25.11 O

ATOM 4184 OE2 GLU B 167 21.552 30.510 36.852 1.00 24.61 O

ATOM 4185 C GLU B 167 26.381 32.095 40.409 1.00 21.25 C

ATOM 4186 O GLU B 167 27.396 32.420 39.793 1.00 21.68 O

ATOM 4187 N GLN B 168 26.410 31.475 41.588 1.00 22.15 N

ATOM 4188 CA GLN B 168 27.666 31.137 42.261 1.00 23.14 C

ATOM 4189 CB GLN B 168 27.452 30.098 43.374 1.00 23.40 C

ATOM 4190 CG GLN B 168 26.823 28.762 42.935 1.00 25.49 C

ATOM 4191 CD GLN B 168 27.298 28.268 41.567 1.00 28.77 C

ATOM 4192 OEl GLN B 168 26.484 28.028 40.669 1.00 30.65 O

ATOM 4193 NE2 GLN B 168 28.615 28.118 41.405 1.00 29.45 N

ATOM 4194 C GLN B 168 28.375 32.371 42.818 1.00 23.46 C

ATOM 4195 O GLN B 168 29.602 32.478 42.724 1.00 23.59 O

ATOM 4196 N GLU B 169 27.602 33.295 43.393 1.00 23.61 N

ATOM 4197 CA GLU B 169 28.146 34.555 43.909 1.00 24.12 C

ATOM 4198 CB GLU B 169 27.057 35.378 44.608 1.00 23.85 C

ATOM 4199 CG GLU B 169 27.575 36.602 45.380 1.00 23.18 C

ATOM 4200 CD GLU B 169 27.475 37.920 44.605 1.00 22.03 C

ATOM 4201 OEl GLU B 169 27.054 37.922 43.429 1.00 20.74 O

ATOM 4202 OE2 GLU B 169 27.820 38.968 45.190 1.00 22.12 O

ATOM 4203 C GLU B 169 28.793 35.374 42.795 1.00 24.66 C

ATOM 4204 O GLU B 169 29.826 36.017 43.011 1.00 24.92 O

ATOM 4205 N ALA B 170 28.175 35.351 41.614 1.00 25.34 N

ATOM 4206 CA ALA B 170 28.701 36.034 40.435 1.00 26.11 C

ATOM 4207 CB ALA B 170 27.761 35.853 39.262 1.00 26.13 C

ATOM 4208 C ALA B 170 30.100 35.535 40.073 1.00 26.81 C

ATOM 4209 O ALA B 170 30.962 36.322 39.678 1.00 26.85 O

ATOM 4210 N LYS B 171 30.309 34.232 40.217 1.00 27.42 N

ATOM 4211 CA LYS B 171 31.603 33.615 39.952 1.00 28.28 C

ATOM 4212 CB LYS B 171 31.451 32.095 39.829 1.00 28.28 C

ATOM 4213 CG LYS B 171 30.800 31.630 38.544 1.00 29.18 C W2025-7029WO / AM102903-PCT

ATOM 4214 CD LYS B 171 30.748 30.116 38.482 1.00 29.92 C

ATOM 4215 CE LYS B 171 30.162 29.633 37.181 1.00 30.64 C

ATOM 4216 NZ LYS B 171 30.339 28.169 37.022 1.00 31.37 N

ATOM 4217 C LYS B 171 32.649 33.973 41.011 1.00 28.59 C

ATOM 4218 O LYS B 171 33.806 34.189 40.678 1.00 28.91 O

ATOM 4219 N GLN B 172 32.244 34.022 42.277 1.00 28.83 N

ATOM 4220 CA GLN B 172 33.143 34.362 43.375 1.00 29.14 C

ATOM 4221 CB GLN B 172 32.409 34.348 44.716 1.00 29.32 C

ATOM 4222 CG GLN B 172 31.821 33.005 45.110 1.00 30.16 C

ATOM 4223 CD GLN B 172 30.999 33.070 46.395 1.00 31.35 C

ATOM 4224 OEl GLN B 172 30.643 34.143 46.870 1.00 32.08 O

ATOM 4225 NE2 GLN B 172 30.716 31.913 46.966 1.00 31.74 N

ATOM 4226 C GLN B 172 33.773 35.728 43.170 1.00 29.09 C

ATOM 4227 O GLN B 172 34.997 35.848 43.105 1.00 29.25 O

ATOM 4228 N ILE B 173 32.914 36.736 43.035 1.00 28.79 N

ATOM 4229 CA ILE B 173 33.312 38.131 43.033 1.00 28.58 C

ATOM 4230 CB ILE B 173 32.280 39.012 43.765 1.00 28.66 C

ATOM 4231 CGl ILE B 173 31.000 39.169 42.940 1.00 28.56 C

ATOM 4232 CDl ILE B 173 30.186 40.335 43.343 1.00 29.23 C

ATOM 4233 CG2 ILE B 173 31.970 38.453 45.137 1.00 28.74 C

ATOM 4234 C ILE B 173 33.578 38.694 41.641 1.00 28.39 C

ATOM 4235 O ILE B 173 33.962 39.839 41.504 1.00 28.51 O

ATOM 4236 N ASN B 174 33.369 37.870 40.624 1.00 28.03 N

ATOM 4237 CA ASN B 174 33.557 38.262 39.219 1.00 27.64 C

ATOM 4238 CB ASN B 174 35.052 38.387 38.872 1.00 28.02 C

ATOM 4239 CG ASN B 174 35.295 38.653 37.395 1.00 28.47 C

ATOM 4240 ODl ASN B 174 34.663 38.049 36.525 1.00 29.43 O

ATOM 4241 ND2 ASN B 174 36.221 39.561 37.107 1.00 29.47 N

ATOM 4242 C ASN B 174 32.779 39.527 38.841 1.00 27.07 C

ATOM 4243 O ASN B 174 33.359 40.595 38.604 1.00 27.14 O

ATOM 4244 N LYS B 175 31.454 39.385 38.816 1.00 26.10 N

ATOM 4245 CA LYS B 175 30.521 40.451 38.452 1.00 25.05 C

ATOM 4246 CB LYS B 175 30.176 41.313 39.674 1.00 25.22 C

ATOM 4247 CG LYS B 175 31.027 42.562 39.843 1.00 26.04 C

ATOM 4248 CD LYS B 175 30.658 43.295 41.124 1.00 27.38 C

ATOM 4249 CE LYS B 175 31.165 44.729 41.132 1.00 29.21 C

ATOM 4250 NZ LYS B 175 30.267 45.657 40.373 1.00 30.36 N

ATOM 4251 C LYS B 175 29.247 39.802 37.912 1.00 23.88 C

ATOM 4252 O LYS B 175 28.961 38.656 38.253 1.00 23.80 O

ATOM 4253 N PRO B 176 28.489 40.517 37.056 1.00 22.68 N

ATOM 4254 CA PRO B 176 27.184 39.985 36.646 1.00 21.47 C

ATOM 4255 CB PRO B 176 26.600 41.106 35.784 1.00 21.57 C

ATOM 4256 CG PRO B 176 27.795 41.843 35.271 1.00 22.40 C

ATOM 4257 CD PRO B 176 28.787 41.804 36.396 1.00 22.72 C

ATOM 4258 C PRO B 176 26.287 39.697 37.853 1.00 20.16 C

ATOM 4259 O PRO B 176 26.272 40.463 38.822 1.00 19.66 O

ATOM 4260 N ARG B 177 25.565 38.585 37.793 1.00 18.76 N

ATOM 4261 CA ARG B 177 24.770 38.135 38.931 1.00 17.27 C

ATOM 4262 CB ARG B 177 24.248 36.714 38.706 1.00 17.22 C

ATOM 4263 CG ARG B 177 23.213 36.596 37.600 1.00 17.12 C

ATOM 4264 CD ARG B 177 22.474 35.275 37.676 1.00 17.12 C

ATOM 4265 NE ARG B 177 21.588 35.107 36.530 1.00 17.26 N

ATOM 4266 CZ ARG B 177 20.319 35.511 36.486 1.00 17.74 C

ATOM 4267 NHl ARG B 177 19.757 36.111 37.533 1.00 16.59 N

ATOM 4268 NH2 ARG B 177 19.607 35.307 35.387 1.00 17.24 N

ATOM 4269 C ARG B 177 23.608 39.072 39.243 1.00 16.39 C

ATOM 4270 O ARG B 177 23.123 39.799 38.373 1.00 16.19 O

ATOM 4271 N LEU B 178 23.179 39.035 40.499 1.00 15.64 N

ATOM 4272 CA LEU B 178 21.967 39.707 40.939 1.00 14.55 C

ATOM 4273 CB LEU B 178 21.841 39.601 42.460 1.00 14.68 C

ATOM 4274 CG LEU B 178 22.932 40.328 43.258 1.00 14.86 C

ATOM 4275 CDl LEU B 178 23.155 39.668 44.609 1.00 14.44 C

ATOM 4276 CD2 LEU B 178 22.610 41.812 43.417 1.00 14.45 C W2025-7029WO / AM102903-PCT

ATOM 4277 C LEU B 178 20.750 39.072 40.266 1.00 13.98 C

ATOM 4278 O LEU B 178 20.765 37.883 39.940 1.00 13.42 O

ATOM 4279 N MET B 179 19.714 39.878 40.043 1.00 13.25 N

ATOM 4280 CA MET B 179 18.464 39.398 39.453 1.00 12.82 C

ATOM 4281 CB MET B 179 17.747 40.526 38.711 1.00 12.99 C

ATOM 4282 CG MET B 179 18.442 41.032 37.466 1.00 13.98 C

ATOM 4283 SD MET B 179 17.737 42.603 36.927 1.00 16.89 S

ATOM 4284 CE MET B 179 16.218 42.069 36.139 1.00 16.53 C

ATOM 4285 C MET B 179 17.531 38.866 40.529 1.00 12.13 C

ATOM 4286 O MET B 179 17.577 39.309 41.678 1.00 11.72 O

ATOM 4287 N VAL B 180 16.688 37.907 40.150 1.00 11.46 N

ATOM 4288 CA VAL B 180 15.584 37.468 40.995 1.00 11.17 C

ATOM 4289 CB VAL B 180 15.817 36.057 41.626 1.00 11.29 C

ATOM 4290 CGl VAL B 180 16.083 34.989 40.558 1.00 11.69 C

ATOM 4291 CG2 VAL B 180 14.642 35.670 42.533 1.00 12.01 C

ATOM 4292 C VAL B 180 14.284 37.544 40.196 1.00 10.55 C

ATOM 4293 O VAL B 180 14.158 36.937 39.126 1.00 10.47 O

ATOM 4294 N THR B 181 13.345 38.339 40.701 1.00 9.42 N

ATOM 4295 CA THR B 181 12.044 38.498 40.059 1.00 8.83 C

ATOM 4296 CB THR B 181 11.850 39.922 39.478 1.00 8.85 C

ATOM 4297 OGl THR B 181 11.865 40.881 40.542 1.00 7.96 O

ATOM 4298 CG2 THR B 181 12.945 40.271 38.471 1.00 9.02 C

ATOM 4299 C THR B 181 10.965 38.231 41.099 1.00 8.57 C

ATOM 4300 O THR B 181 11.265 38.057 42.285 1.00 8.35 O

ATOM 4301 N ALA B 182 -9.711 38.192 40.666 1.00 8.07 N

ATOM 4302 CA ALA B 182 -8.615 38.055 41.619 1.00 7.98 C

ATOM 4303 CB ALA B 182 -8.328 36.577 41.920 1.00 8.00 C

ATOM 4304 C ALA B 182 -7.358 38.741 41.139 1.00 7.93 C

ATOM 4305 O ALA B 182 -7.024 38.685 39.950 1.00 8.06 O

ATOM 4306 N ALA B 183 -6.683 39.395 42.081 1.00 7.84 N

ATOM 4307 CA ALA B 183 -5.343 39.928 41.871 1.00 8.05 C

ATOM 4308 CB ALA B 183 -5.111 41.139 42.751 1.00 8.23 C

ATOM 4309 C ALA B 183 -4.369 38.807 42.219 1.00 7.99 C

ATOM 4310 O ALA B 183 -4.488 38.170 43.273 1.00 7.69 O

ATOM 4311 N VAL B 184 -3.424 38.549 41.320 1.00 7.73 N

ATOM 4312 CA VAL B 184 -2.583 37.361 41.417 1.00 7.89 C

ATOM 4313 CB VAL B 184 -2.990 36.292 40.369 1.00 7.72 C

ATOM 4314 CGl VAL B 184 -4.433 35.834 40.586 1.00 7.50 C

ATOM 4315 CG2 VAL B 184 -2.796 36.821 38.954 1.00 7.26 C

ATOM 4316 C VAL B 184 -1.090 37.660 41.267 1.00 8.03 C

ATOM 4317 O VAL B 184 -0.696 38.678 40.687 1.00 7.71 O

ATOM 4318 N ALA B 185 -0.276 36.735 41.780 1.00 8.61 N

ATOM 4319 CA ALA B 185 1.177 36.868 41.813 1.00 8.53 C

ATOM 4320 CB ALA B 185 1.787 35.716 42.624 1.00 8.57 C

ATOM 4321 C ALA B 185 1.816 36.913 40.431 1.00 8.40 C

ATOM 4322 O ALA B 185 1.307 36.309 39.470 1.00 8.45 O

ATOM 4323 N ALA B 186 2.938 37.628 40.362 1.00 8.62 N

ATOM 4324 CA ALA B 186 3.820 37.663 39.189 1.00 8.70 C

ATOM 4325 CB ALA B 186 4.170 39.098 38.845 1.00 8.64 C

ATOM 4326 C ALA B 186 5.107 36.853 39.395 1.00 8.93 C

ATOM 4327 O ALA B 186 5.783 36.496 38.422 1.00 8.67 O

ATOM 4328 N GLY B 187 5.456 36.577 40.654 1.00 9.24 N

ATOM 4329 CA GLY B 187 6.641 35.768 40.955 1.00 9.58 C

ATOM 4330 C GLY B 187 6.379 34.308 40.630 1.00 10.14 C

ATOM 4331 O GLY B 187 5.370 33.753 41.061 1.00 9.80 O

ATOM 4332 N ILE B 188 7.276 33.688 39.858 1.00 10.38 N

ATOM 4333 CA ILE B 188 7.024 32.336 39.338 1.00 10.46 C

ATOM 4334 CB ILE B 188 8.078 31.893 38.265 1.00 10.30 C

ATOM 4335 CGl ILE B 188 8.155 32.903 37.100 1.00 10.28 C

ATOM 4336 CDl ILE B 188 6.825 33.227 36.391 1.00 10.15 C

ATOM 4337 CG2 ILE B 188 7.815 30.452 37.778 1.00 10.55 C

ATOM 4338 C ILE B 188 6.874 31.300 40.456 1.00 10.59 C

ATOM 4339 O ILE B 188 5.966 30.471 40.403 1.00 10.51 O W2025-7029WO / AM102903-PCT

ATOM 4340 N SER B 189 7.741 31.364 41.469 1.00 10.96 N

ATOM 4341 CA SER B 189 7.626 30.487 42.638 1.00 11.83 C

ATOM 4342 CB SER B 189 8.737 30.783 43.648 1.00 11.79 C

ATOM 4343 OG SER B 189 8.615 29.949 44.790 1.00 15.77 O

ATOM 4344 C SER B 189 6.260 30.636 43.309 1.00 11.36 C

ATOM 4345 O SER B 189 5.597 29.638 43.612 1.00 11.38 O

ATOM 4346 N ASN B 190 5.842 31.884 43.523 1.00 11.01 N

ATOM 4347 CA ASN B 190 4.540 32.163 44.137 1.00 10.55 C

ATOM 4348 CB ASN B 190 4.363 33.661 44.415 1.00 10.66 C

ATOM 4349 CG ASN B 190 5.239 34.167 45.560 1.00 10.83 C

ATOM 4350 ODl ASN B 190 5.652 33.410 46.455 1.00 12.41 O

ATOM 4351 ND2 ASN B 190 5.518 35.461 45.540 1.00 12.01 N

ATOM 4352 C ASN B 190 3.371 31.652 43.289 1.00 10.18 C

ATOM 4353 O ASN B 190 2.381 31.166 43.830 1.00 10.11 O

ATOM 4354 N ILE B 191 3.481 31.781 41.966 1.00 9.89 N

ATOM 4355 CA ILE B 191 2.439 31.293 41.054 1.00 9.97 C

ATOM 4356 CB ILE B 191 2.686 31.710 39.585 1.00 9.87 C

ATOM 4357 CGl ILE B 191 2.636 33.233 39.421 1.00 8.96 C

ATOM 4358 CDl ILE B 191 3.281 33.729 38.117 1.00 8.86 C

ATOM 4359 CG2 ILE B 191 1.653 31.059 38.669 1.00 9.78 C

ATOM 4360 C ILE B 191 2.324 29.770 41.120 1.00 10.50 C

ATOM 4361 O ILE B 191 1.224 29.223 41.225 1.00 10.65 O

ATOM 4362 N GLN B 192 3.471 29.098 41.043 1.00 10.86 N

ATOM 4363 CA GLN B 192 3.522 27.640 41.084 1.00 11.60 C

ATOM 4364 CB GLN B 192 4.956 27.156 40.853 1.00 11.68 C

ATOM 4365 CG GLN B 192 5.413 27.315 39.411 1.00 13.02 C

ATOM 4366 CD GLN B 192 6.861 26.913 39.196 1.00 15.36 C

ATOM 4367 OEl GLN B 192 7.659 26.900 40.132 1.00 18.22 O

ATOM 4368 NE2 GLN B 192 7.209 26.602 37.953 1.00 17.26 N

ATOM 4369 C GLN B 192 2.955 27.046 42.376 1.00 11.63 C

ATOM 4370 O GLN B 192 2.260 26.034 42.339 1.00 12.33 O

ATOM 4371 N SER B 193 3.252 27.668 43.514 1.00 11.65 N

ATOM 4372 CA SER B 193 2.756 27.161 44.796 1.00 11.85 C

ATOM 4373 CB SER B 193 3.769 27.423 45.921 1.00 12.17 C

ATOM 4374 OG SER B 193 3.903 28.804 46.185 1.00 14.44 O

ATOM 4375 C SER B 193 1.371 27.711 45.157 1.00 11.15 C

ATOM 4376 O SER B 193 0.745 27.249 46.110 1.00 11.05 O

ATOM 4377 N GLY B 194 0.885 28.671 44.371 1.00 10.53 N

ATOM 4378 CA GLY B 194 0.345 29.392 44.704 1.00 10.08 C

ATOM 4379 C GLY B 194 1.622 29.032 43.959 1.00 9.64 C

ATOM 4380 O GLY B 194 2.710 29.076 44.542 1.00 9.50 O

ATOM 4381 N TYR B 195 1.504 28.677 42.680 1.00 9.25 N

ATOM 4382 CA TYR B 195 2.680 28.616 41.804 1.00 9.44 C

ATOM 4383 CB TYR B 195 2.736 29.850 40.897 1.00 9.38 C

ATOM 4384 CG TYR B 195 2.467 31.155 41.610 1.00 9.17 C

ATOM 4385 CDl TYR B 195 1.209 31.758 41.545 1.00 10.55 C

ATOM 4386 CEl TYR B 195 0.951 32.961 42.203 1.00 9.41 C

ATOM 4387 CZ TYR B 195 1.962 33.573 42.934 1.00 9.71 C

ATOM 4388 OH TYR B 195 1.699 34.762 43.577 1.00 9.78 O

ATOM 4389 CE2 TYR B 195 3.219 32.993 43.015 1.00 9.30 C

ATOM 4390 CD2 TYR B 195 3.468 31.790 42.349 1.00 9.48 C

ATOM 4391 C TYR B 195 2.777 27.370 40.934 1.00 9.42 C

ATOM 4392 O TYR B 195 1.792 26.946 40.323 1.00 9.06 O

ATOM 4393 N GLU B 196 3.978 26.798 40.896 1.00 9.81 N

ATOM 4394 CA GLU B 196 4.354 25.790 39.907 1.00 9.79 C

ATOM 4395 CB GLU B 196 5.405 24.843 40.488 1.00 10.08 C

ATOM 4396 CG GLU B 196 4.967 24.114 41.748 1.00 10.16 C

ATOM 4397 CD GLU B 196 6.037 23.186 42.308 1.00 10.91 C

ATOM 4398 OEl GLU B 196 5.665 22.103 42.794 1.00 13.25 O

ATOM 4399 OE2 GLU B 196 7.235 23.537 42.264 1.00 11.43 O

ATOM 4400 C GLU B 196 4.930 26.567 38.729 1.00 9.90 C

ATOM 4401 O GLU B 196 6.139 26.789 38.651 1.00 9.92 O

ATOM 4402 N ILE B 197 4.056 27.012 37.830 1.00 9.58 N W2025-7029WO / AM102903-PCT

ATOM 4403 CA ILE B 197 -4.430 28.038 36.853 1.00 10.24 C

ATOM 4404 CB ILE B 197 -3.204 28.593 36.067 1.00 9.85 C

ATOM 4405 CGl ILE B 197 -2.146 29.132 37.038 1.00 9.96 C

ATOM 4406 CDl ILE B 197 -0.834 29.556 36.360 1.00 10.38 C

ATOM 4407 CG2 ILE B 197 -3.641 29.694 35.098 1.00 9.61 C

ATOM 4408 C ILE B 197 -5.599 27.659 35.923 1.00 10.99 C

ATOM 4409 O ILE B 197 -6.551 28.436 35.802 1.00 11.17 O

ATOM 4410 N PRO B 198 -5.552 26.472 35.281 1.00 11.41 N

ATOM 4411 CA PRO B 198 -6.690 26.163 34.405 1.00 11.93 C

ATOM 4412 CB PRO B 198 -6.331 24.787 33.830 1.00 12.03 C

ATOM 4413 CG PRO B 198 -4.845 24.689 33.975 1.00 11.60 C

ATOM 4414 CD PRO B 198 -4.550 25.390 35.264 1.00 11.55 C

ATOM 4415 C PRO B 198 -8.033 26.120 35.152 1.00 12.27 C

ATOM 4416 O PRO B 198 -9.020 26.678 34.670 1.00 12.51 O

ATOM 4417 N GLN B 199 -8.052 25.487 36.324 1.00 12.64 N

ATOM 4418 CA GLN B 199 -9.286 25.320 37.103 1.00 13.07 C

ATOM 4419 CB GLN B 199 -9.090 24.320 38.247 1.00 13.27 C

ATOM 4420 CG GLN B 199 -8.794 22.891 37.801 1.00 14.18 C

ATOM 4421 CD GLN B 199 -7.307 22.586 37.688 1.00 15.29 C

ATOM 4422 OEl GLN B 199 -6.486 23.467 37.431 1.00 14.48 O

ATOM 4423 NE2 GLN B 199 -6.958 21.315 37.870 1.00 18.92 N

ATOM 4424 C GLN B 199 -9.779 26.654 37.649 1.00 13.28 C

ATOM 4425 O GLN B 199 10.959 26.991 37.526 1.00 13.40 O

ATOM 4426 N LEU B 200 -8.861 27.420 38.232 1.00 13.28 N

ATOM 4427 CA LEU B 200 -9.178 28.740 38.767 1.00 13.77 C

ATOM 4428 CB LEU B 200 -7.933 29.334 39.437 1.00 13.82 C

ATOM 4429 CG LEU B 200 -8.003 30.691 40.127 1.00 14.05 C

ATOM 4430 CDl LEU B 200 -8.925 30.653 41.338 1.00 13.46 C

ATOM 4431 CD2 LEU B 200 -6.593 31.104 40.532 1.00 13.94 C

ATOM 4432 C LEU B 200 -9.706 29.682 37.681 1.00 13.98 C

ATOM 4433 O LEU B 200 10.680 30.403 37.898 1.00 14.32 O

ATOM 4434 N SER B 201 -9.065 29.663 36.511 1.00 14.59 N

ATOM 4435 CA SER B 201 -9.423 30.564 35.417 1.00 15.23 C

ATOM 4436 CB SER B 201 -8.397 30.471 34.287 1.00 15.31 C

ATOM 4437 OG SER B 201 -7.130 30.916 34.742 1.00 15.18 O

ATOM 4438 C SER B 201 10.842 30.356 34.888 1.00 15.86 C

ATOM 4439 O SER B 201 11.459 31.300 34.387 1.00 16.18 O

ATOM 4440 N GLN B 202 11.354 29.131 35.018 1.00 16.29 N

ATOM 4441 CA GLN B 202 12.732 28.801 34.633 1.00 17.06 C

ATOM 4442 CB GLN B 202 13.035 27.324 34.907 1.00 17.31 C

ATOM 4443 CG GLN B 202 12.339 26.332 33.996 1.00 19.84 C

ATOM 4444 CD GLN B 202 12.819 24.901 34.213 1.00 22.08 C

ATOM 4445 OEl GLN B 202 13.943 24.670 34.676 1.00 23.97 O

ATOM 4446 NE2 GLN B 202 11.970 23.934 33.875 1.00 24.33 N

ATOM 4447 C GLN B 202 13.773 29.652 35.366 1.00 16.63 C

ATOM 4448 O GLN B 202 14.787 30.029 34.781 1.00 17.08 O

ATOM 4449 N TYR B 203 13.516 29.937 36.645 1.00 15.93 N

ATOM 4450 CA TYR B 203 14.505 30.574 37.524 1.00 15.40 C

ATOM 4451 CB TYR B 203 14.569 29.857 38.878 1.00 15.82 C

ATOM 4452 CG TYR B 203 14.735 28.367 38.739 1.00 16.85 C

ATOM 4453 CDl TYR B 203 13.678 27.503 39.015 1.00 18.28 C

ATOM 4454 CEl TYR B 203 13.819 26.132 38.873 1.00 19.46 C

ATOM 4455 CZ TYR B 203 15.029 25.615 38.440 1.00 19.59 C

ATOM 4456 OH TYR B 203 15.179 24.256 38.293 1.00 20.58 O

ATOM 4457 CE2 TYR B 203 16.091 26.453 38.156 1.00 19.49 C

ATOM 4458 CD2 TYR B 203 15.939 27.823 38.304 1.00 17.98 C

ATOM 4459 C TYR B 203 14.311 32.072 37.731 1.00 14.68 C

ATOM 4460 O TYR B 203 15.263 32.776 38.066 1.00 14.76 O

ATOM 4461 N LEU B 204 13.086 32.556 37.542 1.00 13.72 N

ATOM 4462 CA LEU B 204 12.819 33.988 37.654 1.00 12.71 C

ATOM 4463 CB LEU B 204 11.326 34.256 37.858 1.00 12.66 C

ATOM 4464 CG LEU B 204 10.680 33.817 39.178 1.00 12.00 C

ATOM 4465 CDl LEU B 204 -9.175 33.968 39.084 1.00 12.54 C W2025-7029WO / AM102903-PCT

ATOM 4466 CD2 LEU B 204 11.216 34.626 40.352 1.00 11.36 C

ATOM 4467 C LEU B 204 13.301 34.713 36.406 1.00 12.08 C

ATOM 4468 O LEU B 204 13.168 34.199 35.298 1.00 12.05 O

ATOM 4469 N ASP B 205 13.854 35.910 36.593 1.00 11.52 N

ATOM 4470 CA ASP B 205 14.245 36.763 35.473 1.00 11.20 C

ATOM 4471 CB ASP B 205 15.304 37.772 35.917 1.00 11.40 C

ATOM 4472 CG ASP B 205 16.609 37.102 36.287 1.00 11.97 C

ATOM 4473 ODl ASP B 205 17.076 36.257 35.496 1.00 14.83 O

ATOM 4474 OD2 ASP B 205 17.161 37.405 37.363 1.00 12.16 O

ATOM 4475 C ASP B 205 13.045 37.473 34.855 1.00 10.97 C

ATOM 4476 O ASP B 205 12.950 37.593 33.633 1.00 10.76 O

ATOM 4477 N TYR B 206 12.144 37.951 35.713 1.00 10.62 N

ATOM 4478 CA TYR B 206 10.880 38.549 35.285 1.00 10.39 C

ATOM 4479 CB TYR B 206 10.994 40.070 35.142 1.00 10.65 C

ATOM 4480 CG TYR B 206 11.869 40.489 33.988 1.00 11.38 C

ATOM 4481 CDl TYR B 206 13.176 40.927 34.205 1.00 13.07 C

ATOM 4482 CEl TYR B 206 13.991 41.301 33.141 1.00 13.68 C

ATOM 4483 CZ TYR B 206 13.501 41.229 31.847 1.00 14.25 C

ATOM 4484 OH TYR B 206 14.303 41.594 30.786 1.00 15.55 O

ATOM 4485 CE2 TYR B 206 12.210 40.785 31.605 1.00 13.52 C

ATOM 4486 CD2 TYR B 206 11.401 40.420 32.677 1.00 12.59 C

ATOM 4487 C TYR B 206 -9.758 38.210 36.255 1.00 9.79 C

ATOM 4488 O TYR B 206 -9.995 37.965 37.443 1.00 9.45 O

ATOM 4489 N ILE B 207 -8.541 38.211 35.722 1.00 9.32 N

ATOM 4490 CA ILE B 207 -7.330 37.869 36.464 1.00 9.18 C

ATOM 4491 CB ILE B 207 -6.653 36.608 35.857 1.00 9.46 C

ATOM 4492 CGl ILE B 207 -7.611 35.411 35.909 1.00 9.68 C

ATOM 4493 CDl ILE B 207 -7.293 34.302 34.924 1.00 10.82 C

ATOM 4494 CG2 ILE B 207 -5.343 36.287 36.570 1.00 9.49 C

ATOM 4495 C ILE B 207 -6.409 39.082 36.387 1.00 9.01 C

ATOM 4496 O ILE B 207 -5.873 39.402 35.314 1.00 9.28 O

ATOM 4497 N HIS B 208 -6.257 39.763 37.521 1.00 8.60 N

ATOM 4498 CA HIS B 208 -5.480 40.997 37.609 1.00 8.48 C

ATOM 4499 CB HIS B 208 -6.115 41.977 38.605 1.00 8.46 C

ATOM 4500 CG HIS B 208 -7.540 42.317 38.293 1.00 8.88 C

ATOM 4501 NDl HIS B 208 -8.561 42.160 39.205 1.00 8.94 N

ATOM 4502 CEl HIS B 208 -9.703 42.528 38.652 1.00 9.12 C

ATOM 4503 NE2 HIS B 208 -9.460 42.910 37.410 1.00 9.37 N

ATOM 4504 CD2 HIS B 208 -8.116 42.785 37.160 1.00 9.49 C

ATOM 4505 C HIS B 208 -4.050 40.653 38.009 1.00 8.12 C

ATOM 4506 O HIS B 208 -3.747 40.479 39.194 1.00 8.31 O

ATOM 4507 N VAL B 209 -3.182 40.533 37.007 1.00 7.98 N

ATOM 4508 CA VAL B 209 -1.818 40.068 37.242 1.00 8.35 C

ATOM 4509 CB VAL B 209 -1.198 39.394 35.996 1.00 7.99 C

ATOM 4510 CGl VAL B 209 0.123 38.723 36.368 1.00 8.06 C

ATOM 4511 CG2 VAL B 209 -2.152 38.352 35.418 1.00 8.96 C

ATOM 4512 C VAL B 209 -0.943 41.221 37.708 1.00 8.18 C

ATOM 4513 O VAL B 209 -0.807 42.227 37.009 1.00 8.37 O

ATOM 4514 N MET B 210 -0.335 41.055 38.882 1.00 8.42 N

ATOM 4515 CA MET B 210 0.440 42.127 39.499 1.00 8.49 C

ATOM 4516 CB MET B 210 0.385 42.021 41.026 1.00 8.85 C

ATOM 4517 CG MET B 210 -1.010 42.284 41.584 1.00 9.46 C

ATOM 4518 SD MET B 210 -1.153 42.189 43.385 1.00 9.16 S

ATOM 4519 CE MET B 210 -1.088 40.425 43.665 1.00 10.13 C

ATOM 4520 C MET B 210 1.867 42.188 38.953 1.00 8.35 C

ATOM 4521 O MET B 210 2.846 41.885 39.653 1.00 8.51 O

ATOM 4522 N THR B 211 1.954 42.584 37.685 1.00 8.09 N

ATOM 4523 CA THR B 211 3.202 42.638 36.926 1.00 8.01 C

ATOM 4524 CB THR B 211 2.944 42.580 35.402 1.00 8.17 C

ATOM 4525 OGl THR B 211 1.837 43.427 35.072 1.00 8.13 O

ATOM 4526 CG2 THR B 211 2.631 41.157 34.970 1.00 7.93 C

ATOM 4527 C THR B 211 4.000 43.890 37.274 1.00 8.28 C

ATOM 4528 O THR B 211 4.281 44.741 36.419 1.00 8.37 O W2025-7029WO / AM102903-PCT

ATOM 4529 N TYR B 212 4.351 43.987 38.549 1.00 8.33 N

ATOM 4530 CA TYR B 212 5.193 45.064 39.055 1.00 8.70 C

ATOM 4531 CB TYR B 212 4.404 46.372 39.230 1.00 8.90 C

ATOM 4532 CG TYR B 212 3.011 46.209 39.800 1.00 9.02 C

ATOM 4533 CDl TYR B 212 2.820 45.785 41.113 1.00 9.49 C

ATOM 4534 CEl TYR B 212 1.553 45.639 41.644 1.00 10.52 C

ATOM 4535 CZ TYR B 212 0.449 45.924 40.861 1.00 9.84 C

ATOM 4536 OH TYR B 212 -0.802 45.782 41.405 1.00 11.26 O

ATOM 4537 CE2 TYR B 212 0.604 46.348 39.551 1.00 9.54 C

ATOM 4538 CD2 TYR B 212 1.882 46.492 39.027 1.00 8.71 C

ATOM 4539 C TYR B 212 5.846 44.594 40.355 1.00 8.89 C

ATOM 4540 O TYR B 212 5.695 43.428 40.735 1.00 9.03 O

ATOM 4541 N ASP B 213 6.573 45.487 41.025 1.00 8.99 N

ATOM 4542 CA ASP B 213 7.449 45.118 42.149 1.00 8.85 C

ATOM 4543 CB ASP B 213 6.646 44.759 43.416 1.00 9.11 C

ATOM 4544 CG ASP B 213 5.632 45.824 43.800 1.00 9.22 C

ATOM 4545 ODl ASP B 213 5.961 47.033 43.746 1.00 10.03 O

ATOM 4546 OD2 ASP B 213 4.504 45.443 44.178 1.00 9.91 O

ATOM 4547 C ASP B 213 8.355 43.948 41.754 1.00 9.01 C

ATOM 4548 O ASP B 213 8.634 43.063 42.568 1.00 8.79 O

ATOM 4549 N LEU B 214 8.815 43.950 40.503 1.00 9.14 N

ATOM 4550 CA LEU B 214 9.638 42.853 39.986 1.00 9.68 C

ATOM 4551 CB LEU B 214 9.491 42.736 38.463 1.00 9.98 C

ATOM 4552 CG LEU B 214 8.068 42.457 37.952 1.00 10.55 C

ATOM 4553 CDl LEU B 214 8.027 42.442 36.430 1.00 10.33 C

ATOM 4554 CD2 LEU B 214 7.527 41.144 38.517 1.00 12.25 C

ATOM 4555 C LEU B 214 11.104 42.983 40.393 1.00 10.08 C

ATOM 4556 O LEU B 214 11.868 42.016 40.322 1.00 9.88 O

ATOM 4557 N HIS B 215 11.481 44.189 40.810 1.00 10.34 N

ATOM 4558 CA HIS B 215 12.773 44.452 41.434 1.00 10.72 C

ATOM 4559 CB HIS B 215 13.764 45.039 40.429 1.00 10.72 C

ATOM 4560 CG HIS B 215 14.187 44.081 39.358 1.00 10.01 C

ATOM 4561 NDl HIS B 215 15.034 43.020 39.599 1.00 10.34 N

ATOM 4562 CEl HIS B 215 15.230 42.353 38.474 1.00 9.58 C

ATOM 4563 NE2 HIS B 215 14.546 42.946 37.513 1.00 10.22 N

ATOM 4564 CD2 HIS B 215 13.889 44.033 38.037 1.00 10.58 C

ATOM 4565 C HIS B 215 12.575 45.443 42.568 1.00 11.22 C

ATOM 4566 O HIS B 215 11.595 46.183 42.584 1.00 11.04 O

ATOM 4567 N GLY B 216 13.518 45.459 43.503 1.00 12.08 N

ATOM 4568 CA GLY B 216 13.491 46.409 44.609 1.00 13.00 C

ATOM 4569 C GLY B 216 14.759 46.322 45.424 1.00 13.79 C

ATOM 4570 O GLY B 216 15.610 45.464 45.175 1.00 13.64 O

ATOM 4571 N SER B 217 14.875 47.213 46.409 1.00 14.79 N

ATOM 4572 CA SER B 217 16.093 47.343 47.214 1.00 15.76 C

ATOM 4573 CB SER B 217 15.963 48.506 48.195 1.00 15.41 C

ATOM 4574 OG SER B 217 14.870 48.306 49.067 1.00 16.86 O

ATOM 4575 C SER B 217 16.488 46.069 47.960 1.00 16.20 C

ATOM 4576 O SER B 217 17.657 45.888 48.300 1.00 16.60 O

ATOM 4577 N TRP B 218 15.518 45.187 48.195 1.00 16.78 N

ATOM 4578 CA TRP B 218 15.774 43.912 48.871 1.00 17.44 C

ATOM 4579 CB TRP B 218 14.467 43.131 49.070 1.00 18.02 C

ATOM 4580 CG TRP B 218 13.687 42.868 47.804 1.00 19.56 C

ATOM 4581 CDl TRP B 218 13.837 41.809 46.953 1.00 20.71 C

ATOM 4582 NEl TRP B 218 12.945 41.906 45.910 1.00 21.34 N

ATOM 4583 CE2 TRP B 218 12.185 43.034 46.077 1.00 21.16 C

ATOM 4584 CD2 TRP B 218 12.624 43.668 47.263 1.00 21.01 C

ATOM 4585 CE3 TRP B 218 12.003 44.862 47.662 1.00 21.83 C

ATOM 4586 CZ3 TRP B 218 10.973 45.380 46.870 1.00 21.91 C

ATOM 4587 CH2 TRP B 218 10.560 44.721 45.693 1.00 21.70 C

ATOM 4588 CZ2 TRP B 218 11.153 43.553 45.281 1.00 21.93 C

ATOM 4589 C TRP B 218 16.821 43.063 48.134 1.00 17.34 C

ATOM 4590 O TRP B 218 17.448 42.177 48.721 1.00 17.70 O

ATOM 4591 N GLU B 219 17.020 43.363 46.855 1.00 16.74 N W2025-7029WO / AM102903-PCT

ATOM 4592 CA GLU B 219 17.961 42.618 46.019 1.00 16.60 C

ATOM 4593 CB GLU B 219 17.482 42.623 44.565 1.00 16.53 C

ATOM 4594 CG GLU B 219 16.196 41.850 44.358 1.00 16.41 C

ATOM 4595 CD GLU B 219 15.740 41.841 42.920 1.00 15.97 C

ATOM 4596 OEl GLU B 219 15.606 42.935 42.334 1.00 14.96 O

ATOM 4597 OE2 GLU B 219 15.508 40.737 42.383 1.00 17.18 O

ATOM 4598 C GLU B 219 19.407 43.115 46.119 1.00 16.38 C

ATOM 4599 O GLU B 219 20.344 42.399 45.737 1.00 16.60 O

ATOM 4600 N GLY B 220 19.583 44.335 46.628 1.00 16.03 N

ATOM 4601 CA GLY B 220 20.908 44.935 46.785 1.00 15.72 C

ATOM 4602 C GLY B 220 21.472 45.552 45.518 1.00 15.23 C

ATOM 4603 O GLY B 220 22.638 45.940 45.481 1.00 15.18 O

ATOM 4604 N TYR B 221 20.643 45.636 44.474 1.00 14.75 N

ATOM 4605 CA TYR B 221 21.032 46.231 43.192 1.00 14.68 C

ATOM 4606 CB TYR B 221 21.494 45.155 42.198 1.00 15.58 C

ATOM 4607 CG TYR B 221 22.665 44.342 42.691 1.00 18.27 C

ATOM 4608 CDl TYR B 221 22.470 43.112 43.318 1.00 20.61 C

ATOM 4609 CEl TYR B 221 23.555 42.367 43.793 1.00 22.02 C

ATOM 4610 CZ TYR B 221 24.844 42.858 43.635 1.00 21.96 C

ATOM 4611 OH TYR B 221 25.920 42.131 44.097 1.00 23.74 O

ATOM 4612 CE2 TYR B 221 25.060 44.079 43.020 1.00 22.02 C

ATOM 4613 CD2 TYR B 221 23.971 44.814 42.552 1.00 20.39 C

ATOM 4614 C TYR B 221 19.844 46.972 42.608 1.00 13.60 C

ATOM 4615 O TYR B 221 18.696 46.600 42.867 1.00 12.83 O

ATOM 4616 N THR B 222 20.116 48.017 41.827 1.00 12.50 N

ATOM 4617 CA THR B 222 19.041 48.739 41.138 1.00 11.44 C

ATOM 4618 CB THR B 222 19.538 49.979 40.368 1.00 11.31 C

ATOM 4619 OGl THR B 222 20.471 49.573 39.359 1.00 11.63 O

ATOM 4620 CG2 THR B 222 20.181 50.978 41.306 1.00 11.57 C

ATOM 4621 C THR B 222 18.343 47.828 40.137 1.00 10.96 C

ATOM 4622 O THR B 222 18.967 46.966 39.506 1.00 10.54 O

ATOM 4623 N GLY B 223 17.041 48.035 39.997 1.00 10.51 N

ATOM 4624 CA GLY B 223 16.249 47.270 39.045 1.00 9.58 C

ATOM 4625 C GLY B 223 14.913 47.941 38.826 1.00 9.45 C

ATOM 4626 O GLY B 223 14.456 48.736 39.660 1.00 9.36 O

ATOM 4627 N GLU B 224 14.279 47.604 37.707 1.00 8.97 N

ATOM 4628 CA GLU B 224 13.023 48.233 37.323 1.00 8.65 C

ATOM 4629 CB GLU B 224 12.876 48.258 35.800 1.00 8.58 C

ATOM 4630 CG GLU B 224 13.752 49.326 35.133 1.00 8.77 C

ATOM 4631 CD GLU B 224 13.237 50.760 35.324 1.00 9.30 C

ATOM 4632 OEl GLU B 224 12.215 50.972 36.021 1.00 8.81 O

ATOM 4633 OE2 GLU B 224 13.858 51.684 34.756 1.00 8.48 O

ATOM 4634 C GLU B 224 11.791 47.622 37.976 1.00 8.68 C

ATOM 4635 O GLU B 224 11.745 46.428 38.272 1.00 8.67 O

ATOM 4636 N ASN B 225 10.798 48.475 38.196 1.00 8.34 N

ATOM 4637 CA ASN B 225 9.563 48.092 38.854 1.00 8.48 C

ATOM 4638 CB ASN B 225 8.779 49.356 39.221 1.00 8.23 C

ATOM 4639 CG ASN B 225 7.608 49.071 40.124 1.00 7.73 C

ATOM 4640 ODl ASN B 225 7.555 48.038 40.786 1.00 8.00 O

ATOM 4641 ND2 ASN B 225 6.653 49.993 40.159 1.00 8.04 N

ATOM 4642 C ASN B 225 8.718 47.169 37.979 1.00 8.62 C

ATOM 4643 O ASN B 225 8.319 46.077 38.406 1.00 9.30 O

ATOM 4644 N SER B 226 8.462 47.613 36.751 1.00 8.51 N

ATOM 4645 CA SER B 226 7.615 46.890 35.816 1.00 8.54 C

ATOM 4646 CB SER B 226 6.210 47.514 35.789 1.00 8.77 C

ATOM 4647 OG SER B 226 5.345 46.840 34.887 1.00 9.74 O

ATOM 4648 C SER B 226 8.254 46.865 34.417 1.00 8.34 C

ATOM 4649 O SER B 226 7.684 47.391 33.466 1.00 8.65 O

ATOM 4650 N PRO B 227 9.450 46.249 34.288 1.00 7.78 N

ATOM 4651 CA PRO B 227 10.081 46.206 32.967 1.00 7.68 C

ATOM 4652 CB PRO B 227 11.442 45.577 33.248 1.00 7.39 C

ATOM 4653 CG PRO B 227 11.240 44.755 34.501 1.00 7.07 C

ATOM 4654 CD PRO B 227 10.260 45.561 35.312 1.00 8.12 C W2025-7029WO / AM102903-PCT

ATOM 4655 C PRO B 227 9.284 45.322 32.017 1.00 7.62 C

ATOM 4656 O PRO B 227 8.823 44.262 32.420 1.00 7.39 O

ATOM 4657 N LEU B 228 9.111 45.769 30.775 1.00 7.97 N

ATOM 4658 CA LEU B 228 8.358 44.984 29.792 1.00 8.44 C

ATOM 4659 CB LEU B 228 8.035 45.838 28.557 1.00 8.46 C

ATOM 4660 CG LEU B 228 7.202 45.209 27.432 1.00 8.20 C

ATOM 4661 CDl LEU B 228 5.948 44.529 27.968 1.00 9.35 C

ATOM 4662 CD2 LEU B 228 6.836 46.281 26.420 1.00 9.20 C

ATOM 4663 C LEU B 228 9.098 43.699 29.395 1.00 8.70 C

ATOM 4664 O LEU B 228 8.498 42.617 29.329 1.00 8.70 O

ATOM 4665 N TYR B 229 10.398 43.836 29.140 1.00 9.35 N

ATOM 4666 CA TYR B 229 11.244 42.733 28.699 1.00 9.93 C

ATOM 4667 CB TYR B 229 11.804 43.019 27.299 1.00 9.79 C

ATOM 4668 CG TYR B 229 10.747 43.330 26.262 1.00 10.49 C

ATOM 4669 CDl TYR B 229 9.795 42.375 25.903 1.00 10.27 C

ATOM 4670 CEl TYR B 229 8.822 42.658 24.950 1.00 11.51 C

ATOM 4671 CZ TYR B 229 8.799 43.902 24.343 1.00 11.87 C

ATOM 4672 OH TYR B 229 7.837 44.179 23.396 1.00 12.69 O

ATOM 4673 CE2 TYR B 229 9.735 44.873 24.680 1.00 11.65 C

ATOM 4674 CD2 TYR B 229 10.703 44.581 25.639 1.00 10.46 C

ATOM 4675 C TYR B 229 12.403 42.543 29.658 1.00 10.24 C

ATOM 4676 O TYR B 229 12.605 43.344 30.570 1.00 10.39 O

ATOM 4677 N LYS B 230 13.191 41.500 29.428 1.00 10.83 N

ATOM 4678 CA LYS B 230 14.373 41.290 30.247 1.00 11.26 C

ATOM 4679 CB LYS B 230 14.875 39.844 30.148 1.00 12.05 C

ATOM 4680 CG LYS B 230 15.290 39.383 28.774 1.00 13.85 C

ATOM 4681 CD LYS B 230 15.482 37.864 28.782 1.00 16.48 C

ATOM 4682 CE LYS B 230 16.032 37.367 27.471 1.00 18.28 C

ATOM 4683 NZ LYS B 230 16.546 35.984 27.624 1.00 19.80 N

ATOM 4684 C LYS B 230 15.475 42.299 29.904 1.00 10.93 C

ATOM 4685 O LYS B 230 15.562 42.798 28.774 1.00 10.25 O

ATOM 4686 N TYR B 231 16.290 42.612 30.904 1.00 10.98 N

ATOM 4687 CA TYR B 231 17.546 43.314 30.683 1.00 10.91 C

ATOM 4688 CB TYR B 231 18.040 43.940 31.994 1.00 11.29 C

ATOM 4689 CG TYR B 231 19.087 45.007 31.778 1.00 10.71 C

ATOM 4690 CDl TYR B 231 18.731 46.270 31.300 1.00 12.01 C

ATOM 4691 CEl TYR B 231 19.691 47.253 31.086 1.00 12.04 C

ATOM 4692 CZ TYR B 231 21.024 46.965 31.346 1.00 12.57 C

ATOM 4693 OH TYR B 231 21.978 47.927 31.131 1.00 13.03 O

ATOM 4694 CE2 TYR B 231 21.402 45.724 31.825 1.00 11.98 C

ATOM 4695 CD2 TYR B 231 20.432 44.750 32.031 1.00 11.20 C

ATOM 4696 C TYR B 231 18.545 42.276 30.154 1.00 11.16 C

ATOM 4697 O TYR B 231 18.473 41.112 30.544 1.00 11.12 O

ATOM 4698 N PRO B 232 19.462 42.674 29.247 1.00 10.86 N

ATOM 4699 CA PRO B 232 20.349 41.654 28.664 1.00 10.98 C

ATOM 4700 CB PRO B 232 21.306 42.470 27.774 1.00 10.85 C

ATOM 4701 CG PRO B 232 21.127 43.894 28.170 1.00 11.22 C

ATOM 4702 CD PRO B 232 19.715 44.009 28.675 1.00 11.02 C

ATOM 4703 C PRO B 232 21.127 40.799 29.670 1.00 10.82 C

ATOM 4704 O PRO B 232 21.451 39.652 29.367 1.00 10.83 O

ATOM 4705 N THR B 233 21.414 41.336 30.854 1.00 11.19 N

ATOM 4706 CA THR B 233 22.168 40.584 31.862 1.00 11.80 C

ATOM 4707 CB THR B 233 22.972 41.511 32.803 1.00 11.79 C

ATOM 4708 OGl THR B 233 22.074 42.410 33.460 1.00 12.44 O

ATOM 4709 CG2 THR B 233 24.016 42.308 32.021 1.00 12.06 C

ATOM 4710 C THR B 233 21.306 39.645 32.713 1.00 11.95 C

ATOM 4711 O THR B 233 21.845 38.901 33.536 1.00 12.24 O

ATOM 4712 N ASP B 234 19.984 39.684 32.523 1.00 12.18 N

ATOM 4713 CA ASP B 234 19.056 38.807 33.253 1.00 12.32 C

ATOM 4714 CB ASP B 234 17.594 39.261 33.081 1.00 12.19 C

ATOM 4715 CG ASP B 234 17.290 40.603 33.734 1.00 12.28 C

ATOM 4716 ODl ASP B 234 16.248 41.195 33.367 1.00 11.30 O

ATOM 4717 OD2 ASP B 234 18.062 41.074 34.597 1.00 12.23 O W2025-7029WO / AM102903-PCT

ATOM 4718 C ASP B 234 19.165 37.366 32.760 1.00 12.74 C

ATOM 4719 O ASP B 234 18.694 37.047 31.662 1.00 12.71 O

ATOM 4720 N THR B 235 19.788 36.501 33.556 1.00 12.64 N

ATOM 4721 CA THR B 235 19.850 35.077 33.217 1.00 13.53 C

ATOM 4722 CB THR B 235 21.287 34.604 32.883 1.00 13.39 C

ATOM 4723 OGl THR B 235 22.145 34.848 33.999 1.00 14.77 O

ATOM 4724 CG2 THR B 235 21.835 35.327 31.650 1.00 14.27 C

ATOM 4725 C THR B 235 19.267 34.224 34.344 1.00 13.39 C

ATOM 4726 O THR B 235 18.973 34.735 35.430 1.00 13.60 O

ATOM 4727 N GLY B 236 19.106 32.928 34.083 1.00 13.48 N

ATOM 4728 CA GLY B 236 18.481 32.021 35.048 1.00 13.83 C

ATOM 4729 C GLY B 236 17.109 32.527 35.464 1.00 13.84 C

ATOM 4730 O GLY B 236 16.333 32.986 34.621 1.00 13.83 O

ATOM 4731 N SER B 237 16.826 32.476 36.767 1.00 13.78 N

ATOM 4732 CA SER B 237 15.520 32.899 37.297 1.00 13.99 C

ATOM 4733 CB SER B 237 15.386 32.507 38.771 1.00 13.88 C

ATOM 4734 OG SER B 237 16.347 33.185 39.561 1.00 16.20 O

ATOM 4735 C SER B 237 15.239 34.398 37.106 1.00 13.74 C

ATOM 4736 O SER B 237 14.073 34.813 37.050 1.00 13.94 O

ATOM 4737 N ASN B 238 16.300 35.202 37.004 1.00 13.06 N

ATOM 4738 CA ASN B 238 16.170 36.637 36.730 1.00 12.99 C

ATOM 4739 CB ASN B 238 17.530 37.339 36.800 1.00 13.17 C

ATOM 4740 CG ASN B 238 17.976 37.627 38.232 1.00 14.70 C

ATOM 4741 ODl ASN B 238 17.183 37.563 39.174 1.00 16.32 O

ATOM 4742 ND2 ASN B 238 19.255 37.946 38.396 1.00 17.66 N

ATOM 4743 C ASN B 238 15.495 36.923 35.384 1.00 12.36 C

ATOM 4744 O ASN B 238 14.871 37.971 35.210 1.00 12.35 O

ATOM 4745 N ALA B 239 15.603 35.977 34.451 1.00 11.98 N

ATOM 4746 CA ALA B 239 14.995 36.107 33.118 1.00 11.58 C

ATOM 4747 CB ALA B 239 15.505 35.000 32.193 1.00 11.56 C

ATOM 4748 C ALA B 239 13.462 36.114 33.141 1.00 11.41 C

ATOM 4749 O ALA B 239 12.823 36.394 32.120 1.00 11.06 O

ATOM 4750 N TYR B 240 12.882 35.800 34.299 1.00 11.35 N

ATOM 4751 CA TYR B 240 11.428 35.763 34.448 1.00 11.04 C

ATOM 4752 CB TYR B 240 11.010 34.621 35.384 1.00 11.50 C

ATOM 4753 CG TYR B 240 11.614 33.261 35.079 1.00 11.95 C

ATOM 4754 CDl TYR B 240 11.877 32.858 33.768 1.00 12.73 C

ATOM 4755 CEl TYR B 240 12.422 31.602 33.495 1.00 14.94 C

ATOM 4756 CZ TYR B 240 12.689 30.737 34.544 1.00 15.55 C

ATOM 4757 OH TYR B 240 13.220 29.487 34.293 1.00 17.80 O

ATOM 4758 CE2 TYR B 240 12.423 31.112 35.851 1.00 14.78 C

ATOM 4759 CD2 TYR B 240 11.887 32.364 36.112 1.00 13.70 C

ATOM 4760 C TYR B 240 10.861 37.082 34.974 1.00 10.56 C

ATOM 4761 O TYR B 240 9.640 37.273 34.992 1.00 10.16 O

ATOM 4762 N LEU B 241 11.746 37.987 35.400 1.00 9.69 N

ATOM 4763 CA LEU B 241 11.333 39.227 36.068 1.00 9.25 C

ATOM 4764 CB LEU B 241 12.401 39.674 37.078 1.00 9.07 C

ATOM 4765 CG LEU B 241 12.709 38.701 38.221 1.00 9.88 C

ATOM 4766 CDl LEU B 241 13.844 39.235 39.078 1.00 10.67 C

ATOM 4767 CD2 LEU B 241 11.471 38.433 39.076 1.00 10.23 C

ATOM 4768 C LEU B 241 10.985 40.356 35.092 1.00 8.76 C

ATOM 4769 O LEU B 241 11.605 41.427 35.088 1.00 8.49 O

ATOM 4770 N ASN B 242 9.978 40.101 34.262 1.00 8.85 N

ATOM 4771 CA ASN B 242 9.476 41.096 33.317 1.00 9.10 C

ATOM 4772 CB ASN B 242 10.365 41.176 32.069 1.00 8.82 C

ATOM 4773 CG ASN B 242 10.469 39.852 31.333 1.00 10.29 C

ATOM 4774 ODl ASN B 242 9.612 39.514 30.514 1.00 10.65 O

ATOM 4775 ND2 ASN B 242 11.526 39.102 31.613 1.00 10.47 N

ATOM 4776 C ASN B 242 8.024 40.817 32.941 1.00 8.81 C

ATOM 4777 O ASN B 242 7.550 39.679 33.055 1.00 8.85 O

ATOM 4778 N VAL B 243 7.328 41.867 32.520 1.00 8.91 N

ATOM 4779 CA VAL B 243 5.902 41.791 32.182 1.00 8.99 C

ATOM 4780 CB VAL B 243 5.353 43.169 31.717 1.00 9.01 C W2025-7029WO / AM102903-PCT

ATOM 4781 CGl VAL B 243 3.894 43.051 31.270 1.00 9.62 C

ATOM 4782 CG2 VAL B 243 5.489 44.209 32.834 1.00 9.12 C

ATOM 4783 C VAL B 243 5.613 40.722 31.124 1.00 8.90 C

ATOM 4784 O VAL B 243 4.703 39.904 31.294 1.00 8.42 O

ATOM 4785 N ASP B 244 6.393 40.730 30.045 1.00 9.11 N

ATOM 4786 CA ASP B 244 6.184 39.795 28.941 1.00 9.64 C

ATOM 4787 CB ASP B 244 7.175 40.051 27.799 1.00 10.08 C

ATOM 4788 CG ASP B 244 6.915 39.151 26.600 1.00 11.94 C

ATOM 4789 ODl ASP B 244 6.228 39.584 25.650 1.00 14.87 O

ATOM 4790 OD2 ASP B 244 7.368 37.994 26.629 1.00 14.28 O

ATOM 4791 C ASP B 244 6.248 38.337 29.393 1.00 9.46 C

ATOM 4792 O ASP B 244 5.347 37.553 29.088 1.00 9.34 O

ATOM 4793 N TYR B 245 7.307 37.969 30.114 1.00 9.42 N

ATOM 4794 CA TYR B 245 7.424 36.592 30.581 1.00 9.35 C

ATOM 4795 CB TYR B 245 8.752 36.328 31.301 1.00 9.66 C

ATOM 4796 CG TYR B 245 8.903 34.857 31.597 1.00 10.07 C

ATOM 4797 CDl TYR B 245 9.446 33.996 30.648 1.00 11.93 C

ATOM 4798 CEl TYR B 245 9.558 32.625 30.900 1.00 13.05 C

ATOM 4799 CZ TYR B 245 9.103 32.114 32.103 1.00 12.72 C

ATOM 4800 OH TYR B 245 9.203 30.764 32.356 1.00 13.77 O

ATOM 4801 CE2 TYR B 245 8.539 32.955 33.056 1.00 12.20 C

ATOM 4802 CD2 TYR B 245 8.436 34.312 32.797 1.00 11.24 C

ATOM 4803 C TYR B 245 6.254 36.191 31.478 1.00 9.32 C

ATOM 4804 O TYR B 245 5.686 35.101 31.328 1.00 9.69 O

ATOM 4805 N VAL B 246 5.897 37.073 32.404 1.00 8.94 N

ATOM 4806 CA VAL B 246 4.856 36.772 33.388 1.00 8.46 C

ATOM 4807 CB VAL B 246 4.820 37.828 34.504 1.00 8.68 C

ATOM 4808 CGl VAL B 246 3.662 37.559 35.448 1.00 8.53 C

ATOM 4809 CG2 VAL B 246 6.151 37.820 35.267 1.00 8.11 C

ATOM 4810 C VAL B 246 3.471 36.592 32.758 1.00 8.44 C

ATOM 4811 O VAL B 246 2.771 35.624 33.070 1.00 8.20 O

ATOM 4812 N MET B 247 3.076 37.517 31.884 1.00 8.41 N

ATOM 4813 CA MET B 247 1.770 37.425 31.229 1.00 8.87 C

ATOM 4814 CB MET B 247 1.477 38.673 30.382 1.00 8.81 C

ATOM 4815 CG MET B 247 1.311 39.964 31.193 1.00 8.95 C

ATOM 4816 SD MET B 247 0.129 39.881 32.579 1.00 9.98

ATOM 4817 CE MET B 247 1.375 39.339 31.748 1.00 9.26 C

ATOM 4818 C MET B 247 1.676 36.157 30.383 1.00 9.01 C

ATOM 4819 O MET B 247 0.653 35.477 30.385 1.00 9.11 O

ATOM 4820 N ASN B 248 2.757 35.843 29.674 1.00 9.52 N

ATOM 4821 CA ASN B 248 2.804 34.635 28.868 1.00 9.98 C

ATOM 4822 CB ASN B 248 3.979 34.683 27.893 1.00 10.28 C

ATOM 4823 CG ASN B 248 3.653 35.496 26.658 1.00 11.35 C

ATOM 4824 ODl ASN B 248 2.702 35.186 25.938 1.00 12.73 O

ATOM 4825 ND2 ASN B 248 4.429 36.544 26.411 1.00 12.20 N

ATOM 4826 C ASN B 248 2.823 33.364 29.702 1.00 10.12 C

ATOM 4827 O ASN B 248 2.299 32.335 29.272 1.00 10.28 O

ATOM 4828 N TYR B 249 3.403 33.441 30.901 1.00 9.89 N

ATOM 4829 CA TYR B 249 3.388 32.303 31.813 1.00 9.99 C

ATOM 4830 CB TYR B 249 4.238 32.552 33.070 1.00 10.21 C

ATOM 4831 CG TYR B 249 4.367 31.301 33.919 1.00 10.87 C

ATOM 4832 CDl TYR B 249 5.418 30.407 33.718 1.00 11.59 C

ATOM 4833 CEl TYR B 249 5.532 29.247 34.481 1.00 11.57 C

ATOM 4834 CZ TYR B 249 4.578 28.962 35.444 1.00 11.90 C

ATOM 4835 OH TYR B 249 4.691 27.808 36.186 1.00 12.31 O

ATOM 4836 CE2 TYR B 249 3.509 29.825 35.653 1.00 12.10 C

ATOM 4837 CD2 TYR B 249 3.409 30.987 34.889 1.00 11.23 C

ATOM 4838 C TYR B 249 1.951 31.972 32.215 1.00 9.79 C

ATOM 4839 O TYR B 249 1.542 30.811 32.183 1.00 10.07 O

ATOM 4840 N TRP B 250 1.194 33.001 32.594 1.00 9.51 N

ATOM 4841 CA TRP B 250 0.206 32.825 32.975 1.00 9.42 C

ATOM 4842 CB TRP B 250 0.795 34.132 33.522 1.00 9.09 C

ATOM 4843 CG TRP B 250 0.531 34.298 34.988 1.00 8.24 C W2025-7029WO / AM102903-PCT

ATOM 4844 CDl TRP B 250 0.545 34.922 35.573 1.00 7.99 C

ATOM 4845 NEl TRP B 250 0.435 34.861 36.947 1.00 7.48 N

ATOM 4846 CE2 TRP B 250 -0.715 34.189 37.270 1.00 8.04 C

ATOM 4847 CD2 TRP B 250 -1.348 33.819 36.060 1.00 7.32 C

ATOM 4848 CE3 TRP B 250 -2.561 33.118 36.119 1.00 8.56 C

ATOM 4849 CZ3 TRP B 250 -3.097 32.806 37.364 1.00 7.74 C

ATOM 4850 CH2 TRP B 250 -2.446 33.185 38.546 1.00 8.16 C

ATOM 4851 CZ2 TRP B 250 -1.252 33.871 38.521 1.00 8.17 C

ATOM 4852 C TRP B 250 -1.039 32.260 31.818 1.00 9.44 C

ATOM 4853 O TRP B 250 -1.815 31.328 32.010 1.00 9.23 O

ATOM 4854 N LYS B 251 -0.845 32.811 30.622 1.00 10.13 N

ATOM 4855 CA LYS B 251 -1.546 32.350 29.421 1.00 10.87 C

ATOM 4856 CB LYS B 251 -1.239 33.256 28.219 1.00 10.83 C

ATOM 4857 CG LYS B 251 -1.977 32.840 26.940 1.00 12.48 C

ATOM 4858 CD LYS B 251 -1.450 33.549 25.689 1.00 13.99 C

ATOM 4859 CE LYS B 251 -2.248 33.077 24.463 1.00 16.91 C

ATOM 4860 NZ LYS B 251 -1.972 33.832 23.210 1.00 17.85 N

ATOM 4861 C LYS B 251 -1.212 30.894 29.084 1.00 11.10 C

ATOM 4862 O LYS B 251 -2.119 30.069 28.909 1.00 11.13 O

ATOM 4863 N ASP B 252 0.083 30.587 29.002 1.00 10.86 N

ATOM 4864 CA ASP B 252 0.549 29.246 28.650 1.00 10.95 C

ATOM 4865 CB ASP B 252 2.073 29.209 28.516 1.00 11.38 C

ATOM 4866 CG ASP B 252 2.580 30.015 27.325 1.00 11.36 C

ATOM 4867 ODl ASP B 252 1.753 30.411 26.473 1.00 12.25 O

ATOM 4868 OD2 ASP B 252 3.807 30.248 27.241 1.00 12.35 O

ATOM 4869 C ASP B 252 0.089 28.193 29.652 1.00 11.19 C

ATOM 4870 O ASP B 252 -0.136 27.041 29.279 1.00 11.27 O

ATOM 4871 N ASN B 253 -0.053 28.594 30.915 1.00 11.06 N

ATOM 4872 CA ASN B 253 -0.438 27.660 31.973 1.00 11.49 C

ATOM 4873 CB ASN B 253 0.519 27.780 33.169 1.00 11.64 C

ATOM 4874 CG ASN B 253 1.937 27.356 32.812 1.00 12.60 C

ATOM 4875 ODl ASN B 253 2.247 26.161 32.738 1.00 14.25 O

ATOM 4876 ND2 ASN B 253 2.800 28.332 32.566 1.00 11.70 N

ATOM 4877 C ASN B 253 -1.928 27.671 32.372 1.00 11.25 C

ATOM 4878 O ASN B 253 -2.306 27.131 33.410 1.00 11.38 O

ATOM 4879 N GLY B 254 -2.774 28.260 31.529 1.00 11.24 N

ATOM 4880 CA GLY B 254 -4.215 27.982 31.605 1.00 11.27 C

ATOM 4881 C GLY B 254 -5.196 29.138 31.605 1.00 11.44 C

ATOM 4882 O GLY B 254 -6.412 28.926 31.511 1.00 11.72 O

ATOM 4883 N ALA B 255 -4.684 30.358 31.719 1.00 11.16 N

ATOM 4884 CA ALA B 255 -5.546 31.527 31.771 1.00 11.16 C

ATOM 4885 CB ALA B 255 -4.907 32.622 32.629 1.00 10.81 C

ATOM 4886 C ALA B 255 -5.839 32.039 30.364 1.00 11.27 C

ATOM 4887 O ALA B 255 -4.912 32.339 29.611 1.00 11.78 O

ATOM 4888 N PRO B 256 -7.131 32.115 29.993 1.00 11.63 N

ATOM 4889 CA PRO B 256 -7.489 32.677 28.690 1.00 11.61 C

ATOM 4890 CB PRO B 256 -9.018 32.678 28.720 1.00 11.77 C

ATOM 4891 CG PRO B 256 -9.380 31.584 29.686 1.00 11.83 C

ATOM 4892 CD PRO B 256 -8.318 31.668 30.748 1.00 11.39 C

ATOM 4893 C PRO B 256 -6.955 34.103 28.559 1.00 11.57 C

ATOM 4894 O PRO B 256 -7.092 34.895 29.489 1.00 11.16 O

ATOM 4895 N ALA B 257 -6.339 34.409 27.419 1.00 11.74 N

ATOM 4896 CA ALA B 257 -5.787 35.742 27.157 1.00 12.06 C

ATOM 4897 CB ALA B 257 -5.282 35.833 25.734 1.00 12.34 C

ATOM 4898 C ALA B 257 -6.804 36.851 27.439 1.00 12.14 C

ATOM 4899 O ALA B 257 -6.464 37.881 28.029 1.00 11.74 O

ATOM 4900 N GLU B 258 -8.054 36.615 27.036 1.00 12.50 N

ATOM 4901 CA GLU B 258 -9.137 37.591 27.211 1.00 12.67 C

ATOM 4902 CB GLU B 258 10.390 37.153 26.443 1.00 12.82 C

ATOM 4903 CG GLU B 258 11.022 35.851 26.933 1.00 15.64 C

ATOM 4904 CD GLU B 258 10.549 34.615 26.177 1.00 18.20 C

ATOM 4905 OEl GLU B 258 -9.462 34.652 25.549 1.00 17.80 O

ATOM 4906 OE2 GLU B 258 11.282 33.594 26.206 1.00 19.97 O W2025-7029WO / AM102903-PCT

ATOM 4907 C GLU B 258 -9.504 37.907 28.667 1.00 12.13 C

ATOM 4908 O GLU B 258 10.081 38.956 28.940 1.00 12.37 O

ATOM 4909 N LYS B 259 -9.195 36.991 29.584 1.00 11.38 N

ATOM 4910 CA LYS B 259 -9.458 37.203 31.007 1.00 10.59 C

ATOM 4911 CB LYS B 259 -9.826 35.889 31.702 1.00 10.78 C

ATOM 4912 CG LYS B 259 11.223 35.387 31.392 1.00 10.76 C

ATOM 4913 CD LYS B 259 11.581 34.200 32.277 1.00 11.28 C

ATOM 4914 CE LYS B 259 13.050 33.824 32.101 1.00 11.78 C

ATOM 4915 NZ LYS B 259 13.430 32.675 32.968 1.00 9.82 N

ATOM 4916 C LYS B 259 -8.266 37.833 31.710 1.00 10.26 C

ATOM 4917 O LYS B 259 -8.398 38.307 32.832 1.00 10.09 O

ATOM 4918 N LEU B 260 -7.110 37.826 31.047 1.00 9.55 N

ATOM 4919 CA LEU B 260 -5.876 38.305 31.664 1.00 9.76 C

ATOM 4920 CB LEU B 260 -4.654 37.608 31.055 1.00 9.59 C

ATOM 4921 CG LEU B 260 -4.401 36.168 31.514 1.00 10.21 C

ATOM 4922 CDl LEU B 260 -3.390 35.468 30.597 1.00 11.12 C

ATOM 4923 CD2 LEU B 260 -3.945 36.115 32.975 1.00 9.52 C

ATOM 4924 C LEU B 260 -5.744 39.815 31.563 1.00 9.60 C

ATOM 4925 O LEU B 260 -5.848 40.391 30.475 1.00 9.62 O

ATOM 4926 N ILE B 261 -5.503 40.443 32.711 1.00 9.49 N

ATOM 4927 CA ILE B 261 -5.387 41.891 32.799 1.00 9.33 C

ATOM 4928 CB ILE B 261 -6.498 42.481 33.710 1.00 9.22 C

ATOM 4929 CGl ILE B 261 -7.894 42.056 33.220 1.00 9.31 C

ATOM 4930 CDl ILE B 261 -8.259 42.545 31.806 1.00 9.81 C

ATOM 4931 CG2 ILE B 261 -6.385 43.996 33.806 1.00 8.90 C

ATOM 4932 C ILE B 261 -3.990 42.266 33.298 1.00 9.15 C

ATOM 4933 O ILE B 261 -3.575 41.854 34.385 1.00 9.52 O

ATOM 4934 N VAL B 262 -3.277 43.042 32.483 1.00 9.04 N

ATOM 4935 CA VAL B 262 -1.888 43.423 32.747 1.00 8.79 C

ATOM 4936 CB VAL B 262 -1.192 43.900 31.439 1.00 8.86 C

ATOM 4937 CGl VAL B 262 0.270 44.294 31.694 1.00 8.98 C

ATOM 4938 CG2 VAL B 262 -1.269 42.800 30.374 1.00 8.70 C

ATOM 4939 C VAL B 262 -1.806 44.504 33.823 1.00 8.79 C

ATOM 4940 O VAL B 262 -2.544 45.488 33.774 1.00 8.43 O

ATOM 4941 N GLY B 263 -0.898 44.318 34.783 1.00 8.67 N

ATOM 4942 CA GLY B 263 -0.704 45.275 35.875 1.00 8.40 C

ATOM 4943 C GLY B 263 0.220 46.435 35.538 1.00 8.65 C

ATOM 4944 O GLY B 263 1.357 46.234 35.082 1.00 8.61 O

ATOM 4945 N PHE B 264 -0.283 47.648 35.780 1.00 8.41 N

ATOM 4946 CA PHE B 264 0.423 48.906 35.520 1.00 8.43 C

ATOM 4947 CB PHE B 264 -0.360 49.762 34.513 1.00 8.49 C

ATOM 4948 CG PHE B 264 -0.237 49.312 33.082 1.00 8.82 C

ATOM 4949 CDl PHE B 264 -0.937 48.199 32.617 1.00 9.55 C

ATOM 4950 CEl PHE B 264 -0.830 47.790 31.286 1.00 9.08 C

ATOM 4951 C Z PHE B 264 -0.039 48.518 30.399 1.00 8.24 C

ATOM 4952 CE2 PHE B 264 0.657 49.642 30.852 1.00 9.45 C

ATOM 4953 CD2 PHE B 264 0.547 50.036 32.186 1.00 8.67 C

ATOM 4954 C PHE B 264 0.553 49.709 36.815 1.00 8.78 C

ATOM 4955 O PHE B 264 -0.463 50.074 37.411 1.00 8.88 O

ATOM 4956 N PRO B 265 1.800 49.983 37.260 1.00 8.97 N

ATOM 4957 CA PRO B 265 2.050 50.777 38.465 1.00 8.49 C

ATOM 4958 CB PRO B 265 3.364 50.192 38.985 1.00 8.62 C

ATOM 4959 CG PRO B 265 4.110 49.816 37.721 1.00 9.34 C

ATOM 4960 CD PRO B 265 3.058 49.495 36.663 1.00 8.94 C

ATOM 4961 C PRO B 265 2.208 52.280 38.200 1.00 8.24 C

ATOM 4962 O PRO B 265 3.009 52.684 37.354 1.00 7.91 O

ATOM 4963 N THR B 266 1.450 53.092 38.932 1.00 7.77 N

ATOM 4964 CA THR B 266 1.614 54.545 38.895 1.00 8.00 C

ATOM 4965 CB THR B 266 0.253 55.273 38.941 1.00 7.64 C

ATOM 4966 OGl THR B 266 -0.492 54.792 40.063 1.00 8.09 O

ATOM 4967 CG2 THR B 266 -0.540 55.013 37.658 1.00 8.38 C

ATOM 4968 C THR B 266 2.499 55.004 40.057 1.00 7.78 C

ATOM 4969 O THR B 266 2.278 56.064 40.652 1.00 8.26 O W2025-7029WO / AM102903-PCT

ATOM 4970 N TYR B 267 3.501 54.184 40.366 1.00 8.34 N

ATOM 4971 CA TYR B 267 4.513 54.480 41.374 1.00 8.41 C

ATOM 4972 CB TYR B 267 4.063 53.964 42.751 1.00 8.54 C

ATOM 4973 CG TYR B 267 3.977 52.446 42.826 1.00 9.03 C

ATOM 4974 CDl TYR B 267 5.079 51.682 43.225 1.00 9.18 C

ATOM 4975 CEl TYR B 267 5.009 50.284 43.285 1.00 7.87 C

ATOM 4976 CZ TYR B 267 3.830 49.646 42.931 1.00 8.27 C

ATOM 4977 OH TYR B 267 3.746 48.276 42.983 1.00 9.16 O

ATOM 4978 CE2 TYR B 267 2.724 50.387 42.533 1.00 8.29 C

ATOM 4979 CD2 TYR B 267 2.803 51.775 42.477 1.00 8.26 C

ATOM 4980 C TYR B 267 5.821 53.797 40.963 1.00 8.50 C

ATOM 4981 O TYR B 267 5.820 52.908 40.101 1.00 8.37 O

ATOM 4982 N GLY B 268 6.927 54.198 41.582 1.00 8.18 N

ATOM 4983 CA GLY B 268 8.210 53.533 41.341 1.00 8.74 C

ATOM 4984 C GLY B 268 8.892 53.107 42.631 1.00 8.81 C

ATOM 4985 O GLY B 268 8.463 53.500 43.723 1.00 8.86 O

ATOM 4986 N HIS B 269 9.941 52.291 42.504 1.00 8.93 N

ATOM 4987 CA HIS B 269 10.791 51.929 43.648 1.00 9.16 C

ATOM 4988 CB HIS B 269 11.177 50.444 43.623 1.00 9.58 C

ATOM 4989 CG HIS B 269 10.054 49.519 43.974 1.00 10.03 C

ATOM 4990 NDl HIS B 269 9.896 48.985 45.235 1.00 12.11 N

ATOM 4991 CEl HIS B 269 8.824 48.211 45.251 1.00 12.84 C

ATOM 4992 NE2 HIS B 269 8.277 48.232 44.050 1.00 10.55 N

ATOM 4993 CD2 HIS B 269 9.029 49.040 43.231 1.00 11.75 C

ATOM 4994 C HIS B 269 12.060 52.761 43.623 1.00 9.20 C

ATOM 4995 O HIS B 269 12.669 52.936 42.567 1.00 9.47 O

ATOM 4996 N ASN B 270 12.470 53.262 44.786 1.00 9.09 N

ATOM 4997 CA ASN B 270 13.738 53.986 44.873 1.00 9.23 C

ATOM 4998 CB ASN B 270 13.556 55.471 45.244 1.00 9.24 C

ATOM 4999 CG ASN B 270 12.857 55.676 46.578 1.00 9.42 C

ATOM 5000 ODl ASN B 270 12.728 54.757 47.377 1.00 10.53 O

ATOM 5001 ND2 ASN B 270 12.420 56.904 46.828 1.00 10.75 N

ATOM 5002 C ASN B 270 14.742 53.269 45.765 1.00 9.47 C

ATOM 5003 O ASN B 270 14.376 52.367 46.530 1.00 9.20 O

ATOM 5004 N PHE B 271 16.005 53.663 45.627 1.00 9.80 N

ATOM 5005 CA PHE B 271 17.144 52.919 46.149 1.00 10.60 C

ATOM 5006 CB PHE B 271 17.821 52.111 45.034 1.00 10.87 C

ATOM 5007 CG PHE B 271 16.949 51.058 44.379 1.00 10.81 C

ATOM 5008 CDl PHE B 271 15.980 51.409 43.437 1.00 11.53 C

ATOM 5009 CEl PHE B 271 15.198 50.437 42.809 1.00 11.17 C

ATOM 5010 CZ PHE B 271 15.402 49.096 43.095 1.00 11.57 C

ATOM 5011 CE2 PHE B 271 16.391 48.730 44.010 1.00 11.93 C

ATOM 5012 CD2 PHE B 271 17.164 49.709 44.637 1.00 11.15 C

ATOM 5013 C PHE B 271 18.173 53.941 46.614 1.00 11.16 C

ATOM 5014 O PHE B 271 18.236 55.046 46.070 1.00 11.39 O

ATOM 5015 N ILE B 272 18.984 53.563 47.602 1.00 11.49 N

ATOM 5016 CA ILE B 272 20.204 54.298 47.923 1.00 12.02 C

ATOM 5017 CB ILE B 272 20.513 54.324 49.455 1.00 12.20 C

ATOM 5018 CGl ILE B 272 19.328 54.877 50.266 1.00 12.18 C

ATOM 5019 CDl ILE B 272 18.861 56.287 49.887 1.00 12.99 C

ATOM 5020 CG2 ILE B 272 21.823 55.086 49.744 1.00 12.29 C

ATOM 5021 C ILE B 272 21.370 53.656 47.169 1.00 12.53 C

ATOM 5022 O ILE B 272 21.713 52.501 47.407 1.00 12.29 O

ATOM 5023 N LEU B 273 21.961 54.405 46.242 1.00 13.18 N

ATOM 5024 CA LEU B 273 23.107 53.920 45.471 1.00 14.44 C

ATOM 5025 CB LEU B 273 23.416 54.874 44.311 1.00 14.39 C

ATOM 5026 CG LEU B 273 22.387 54.990 43.178 1.00 14.03 C

ATOM 5027 CDl LEU B 273 22.665 56.229 42.335 1.00 13.87 C

ATOM 5028 CD2 LEU B 273 22.370 53.733 42.309 1.00 14.39 C

ATOM 5029 C LEU B 273 24.338 53.773 46.362 1.00 15.31 C

ATOM 5030 O LEU B 273 24.622 54.655 47.175 1.00 15.55 O

ATOM 5031 N SER B 274 25.052 52.658 46.214 1.00 16.54 N

ATOM 5032 CA SER B 274 26.290 52.416 46.970 1.00 17.85 C W2025-7029WO / AM102903-PCT

ATOM 5033 CB SER B 274 26.712 50.949 46.862 1.00 17.71 C

ATOM 5034 OG SER B 274 25.722 50.086 47.394 1.00 18.52 O

ATOM 5035 C SER B 274 27.416 53.323 46.473 1.00 18.77 C

ATOM 5036 O SER B 274 28.343 53.663 47.220 1.00 18.81 O

ATOM 5037 N ASN B 275 27.313 53.705 45.203 1.00 19.69 N

ATOM 5038 CA ASN B 275 28.258 54.597 44.550 1.00 20.93 C

ATOM 5039 CB ASN B 275 29.337 53.771 43.840 1.00 21.17 C

ATOM 5040 CG ASN B 275 30.424 54.623 43.199 1.00 22.47 C

ATOM 5041 ODl ASN B 275 30.376 55.856 43.216 1.00 22.98 O

ATOM 5042 ND2 ASN B 275 31.420 53.954 42.626 1.00 23.78 N

ATOM 5043 C ASN B 275 27.487 55.456 43.551 1.00 21.25 C

ATOM 5044 O ASN B 275 26.956 54.925 42.572 1.00 21.36 O

ATOM 5045 N PRO B 276 27.405 56.781 43.805 1.00 21.92 N

ATOM 5046 CA PRO B 276 26.727 57.746 42.920 1.00 22.21 C

ATOM 5047 CB PRO B 276 26.999 59.098 43.595 1.00 22.46 C

ATOM 5048 CG PRO B 276 27.246 58.764 45.019 1.00 22.57 C

ATOM 5049 CD PRO B 276 27.955 57.443 45.004 1.00 22.15 C

ATOM 5050 C PRO B 276 27.254 57.765 41.482 1.00 22.30 C

ATOM 5051 O PRO B 276 26.558 58.242 40.585 1.00 22.48 O

ATOM 5052 N SER B 277 28.469 57.258 41.273 1.00 22.22 N

ATOM 5053 CA SER B 277 29.063 57.151 39.935 1.00 22.45 C

ATOM 5054 CB SER B 277 30.582 56.993 40.037 1.00 22.59 C

ATOM 5055 OG SER B 277 31.188 58.206 40.435 1.00 24.14 O

ATOM 5056 C SER B 277 28.483 55.990 39.127 1.00 21.95 C

ATOM 5057 O SER B 277 28.527 56.001 37.893 1.00 22.01 O

ATOM 5058 N ASN B 278 27.954 54.994 39.834 1.00 21.44 N

ATOM 5059 CA ASN B 278 27.384 53.799 39.220 1.00 21.05 C

ATOM 5060 CB ASN B 278 27.914 52.552 39.932 1.00 21.40 C

ATOM 5061 CG ASN B 278 27.695 51.275 39.138 1.00 23.18 C

ATOM 5062 ODl ASN B 278 26.926 51.238 38.172 1.00 25.29 O

ATOM 5063 ND2 ASN B 278 28.378 50.210 39.549 1.00 24.79 N

ATOM 5064 C ASN B 278 25.857 53.850 39.270 1.00 20.22 C

ATOM 5065 O ASN B 278 25.254 53.616 40.321 1.00 19.82 O

ATOM 5066 N THR B 279 25.243 54.148 38.125 1.00 19.33 N

ATOM 5067 CA THR B 279 23.818 54.487 38.063 1.00 18.76 C

ATOM 5068 CB THR B 279 23.623 55.982 37.733 1.00 18.84 C

ATOM 5069 OGl THR B 279 24.218 56.268 36.461 1.00 18.85 O

ATOM 5070 CG2 THR B 279 24.250 56.861 38.806 1.00 18.94 C

ATOM 5071 C THR B 279 22.994 53.676 37.055 1.00 17.97 C

ATOM 5072 O THR B 279 21.831 53.995 36.810 1.00 17.99 O

ATOM 5073 N GLY B 280 23.595 52.644 36.473 1.00 17.20 N

ATOM 5074 CA GLY B 280 22.903 51.797 35.503 1.00 16.69 C

ATOM 5075 C GLY B 280 22.035 50.749 36.169 1.00 16.29 C

ATOM 5076 O GLY B 280 21.939 50.693 37.404 1.00 16.15 O

ATOM 5077 N ILE B 281 21.394 49.917 35.352 1.00 15.75 N

ATOM 5078 CA ILE B 281 20.632 48.781 35.859 1.00 15.50 C

ATOM 5079 CB ILE B 281 19.741 48.141 34.755 1.00 15.18 C

ATOM 5080 CGl ILE B 281 18.736 49.163 34.191 1.00 15.01 C

ATOM 5081 CDl ILE B 281 17.585 49.545 35.138 1.00 13.50 C

ATOM 5082 CG2 ILE B 281 19.037 46.868 35.267 1.00 15.30 C

ATOM 5083 C ILE B 281 21.612 47.754 36.422 1.00 15.79 C

ATOM 5084 O ILE B 281 22.567 47.347 35.739 1.00 16.01 O

ATOM 5085 N GLY B 282 21.381 47.353 37.670 1.00 15.59 N

ATOM 5086 CA GLY B 282 22.224 46.363 38.330 1.00 15.80 C

ATOM 5087 C GLY B 282 23.345 46.968 39.159 1.00 15.98 C

ATOM 5088 O GLY B 282 24.209 46.239 39.662 1.00 16.18 O

ATOM 5089 N ALA B 283 23.332 48.295 39.295 1.00 16.00 N

ATOM 5090 CA ALA B 283 24.283 49.009 40.156 1.00 16.15 C

ATOM 5091 CB ALA B 283 24.179 50.506 39.933 1.00 16.00 C

ATOM 5092 C ALA B 283 24.025 48.671 41.629 1.00 16.14 C

ATOM 5093 O ALA B 283 22.871 48.534 42.039 1.00 15.98 O

ATOM 5094 N PRO B 284 25.098 48.534 42.430 1.00 16.28 N

ATOM 5095 CA PRO B 284 24.942 48.151 43.838 1.00 16.22 C W2025-7029WO / AM102903-PCT

ATOM 5096 CB PRO B 284 26.388 48. 048 44.341 .00 16.42 C

ATOM 5097 CG PRO B 284 27.221 47.918 43.109 .00 16.78 C

ATOM 5098 CD PRO B 284 26.515 48.720 42.069 .00 16.17 C

ATOM 5099 C PRO B 284 24.181 49.200 44.642 .00 16.22 C

ATOM 5100 O PRO B 284 24.399 50.401 44.459 .00 16.48 O

ATOM 5101 N THR B 285 23.282 48.738 45.505 .00 16.08 N

ATOM 5102 CA THR B 285 22.532 49.624 46.391 .00 16.20 C

ATOM 5103 CB THR B 285 21.028 49.673 46.028 .00 15.99 C

ATOM 5104 OGl THR B 285 20.476 48.348 46.041 .00 16.53 O

ATOM 5105 CG2 THR B 285 20.836 50.283 44.655 .00 16.35 C

ATOM 5106 C THR B 285 22.718 49.218 47.854 .00 16.17 C

ATOM 5107 O THR B 285 23.129 48.090 48.144 .00 16.22 O

ATOM 5108 N SER B 286 22.428 50.141 48.771 .00 16.17 N

ATOM 5109 CA SER B 286 22.629 49.896 50.202 1.00 16.32 C

ATOM 5110 CB SER B 286 23.642 50. 50.785 1.00 16.48 C

ATOM 5111 OG SER B 286 23.211 52. 220 50.595 1.00 17.94 O

ATOM 5112 C SER B 286 21.330 49. 51.018 1.00 15.91 C

ATOM 5113 O SER B 286 21.351 49. 714 52.239 1.00 16.33 O

ATOM 5114 N GLY B 287 20.203 50.090 50.340 1.00 14.93 N

ATOM 5115 CA GLY B 287 18.898 50.012 50.987 1.00 13.97 C

ATOM 5116 C GLY B 287 17.809 50.722 50.211 1.00 13.34 C

ATOM 5117 O GLY B 287 18.061 51.270 49.133 1.00 12.93 O

ATOM 5118 N ALA B 288 16.597 50.702 50.768 1.00 12.76 N

ATOM 5119 CA ALA B 288 15.444 51.402 50.197 1.00 12.28 C

ATOM 5120 CB ALA B 288 14.174 51.048 50.968 1.00 11.98 C

ATOM 5121 C ALA B 288 15.663 52.907 50.201 1.00 11.90 C

ATOM 5122 O ALA B 288 16.266 53.452 51.132 1.00 11.65 O

ATOM 5123 N GLY B 289 15.183 53.574 49.155 1.00 11.55 N

ATOM 5124 CA GLY B 289 15.271 55.028 49.076 1.00 11.23 C

ATOM 5125 C GLY B 289 14.239 55.719 49.951 1.00 11.30 C

ATOM 5126 O GLY B 289 13.408 55.056 50.582 1.00 11.03 O

ATOM 5127 N PRO B 290 14.263 57.064 49.974 1.00 11.46 N

ATOM 5128 CA PRO B 290 13.471 57.844 50.924 1.00 11.64 C

ATOM 5129 CB PRO B 290 13.942 59.289 50.696 1.00 11.86 C

ATOM 5130 CG PRO B 290 15.113 59.209 49.798 1.00 12.21 C

ATOM 5131 CD PRO B 290 15.045 57.926 49.068 1.00 11.36 C

ATOM 5132 C PRO B 290 11.975 57.769 50.682 1.00 11.60 C

ATOM 5133 O PRO B 290 11.529 57.737 49.536 1.00 11.74 O

ATOM 5134 N ALA B 291 11.210 57.745 51.769 1.00 11.56 N

ATOM 5135 CA ALA B 291 9.774 57.944 51.689 1.00 11.71 C

ATOM 5136 CB ALA B 291 9.150 57.891 53.081 1.00 11.69 C

ATOM 5137 C ALA B 291 9.475 59.284 51.019 1.00 11.92 C

ATOM 5138 O ALA B 291 10.200 60.267 51.211 1.00 12.19 O

ATOM 5139 N GLY B 292 8.415 59.309 50.222 1.00 12.06 N

ATOM 5140 CA GLY B 292 7.959 60.539 49.594 1.00 12.27 C

ATOM 5141 C GLY B 292 7.259 61.429 50.603 1.00 12.61 C

ATOM 5142 O GLY B 292 6.732 60.926 51.604 1.00 12.28 O

ATOM 5143 N PRO B 293 7.248 62.753 50.354 1.00 12.95 N

ATOM 5144 CA PRO B 293 6.643 63.693 51.304 1.00 13.23 C

ATOM 5145 CB PRO B 293 7.168 65.057 50.835 1.00 13.17 C

ATOM 5146 CG PRO B 293 7.419 64.881 49.374 1.00 13.58 C

ATOM 5147 CD PRO B 293 7.825 63.444 49.181 1.00 12.93 C

ATOM 5148 C PRO B 293 5.110 63.670 51.329 1.00 13.40 C

ATOM 5149 O PRO B 293 4.514 64.256 52.229 1.00 13.68 O

ATOM 5150 N TYR B 294 4.486 62. 50.362 1.00 13.37 N

ATOM 5151 CA TYR B 294 3.029 62. 883 50.320 1.00 13.49 C

ATOM 5152 CB TYR B 294 2.480 63.280 48.944 1.00 13.77 C

ATOM 5153 CG TYR B 294 2.558 64.767 48.682 1.00 14.40 C

ATOM 5154 CDl TYR B 294 3.634 65.314 47.979 1.00 15.49 C

ATOM 5155 CEl TYR B 294 3.718 66.683 47.744 1.00 16.04 C

ATOM 5156 C Z TYR B 294 2.719 67.523 48.217 1.00 16.10 C

ATOM 5157 OH TYR B 294 2.805 880 47.979 1.00 16.84 O

ATOM 5158 CE2 TYR B 294 1.643 67.007 48.923 1.00 15.91 C W2025-7029WO / AM102903-PCT

ATOM 5159 CD2 TYR B 294 1.565 65.633 49.151 1.00 15.43 C

ATOM 5160 C TYR B 294 2.519 61.505 50.718 1.00 13.30 C

ATOM 5161 O TYR B 294 1.661 61.396 51.592 1.00 13.68 O

ATOM 5162 N ALA B 295 3.045 60.457 50.086 1.00 12.77 N

ATOM 5163 CA ALA B 295 2.570 59.098 50.340 1.00 12.64 C

ATOM 5164 CB ALA B 295 2.730 58.216 49.090 1.00 12.63 C

ATOM 5165 C ALA B 295 3.234 58.451 51.556 1.00 12.59 C

ATOM 5166 O ALA B 295 2.705 57.488 52.103 1.00 12.66 O

ATOM 5167 N LYS B 296 4.378 58.998 51.979 1.00 12.43 N

ATOM 5168 CA LYS B 296 5.087 58.555 53.198 1.00 12.51 C

ATOM 5169 CB LYS B 296 4.254 58.845 54.467 1.00 12.55 C

ATOM 5170 CG LYS B 296 3.568 60.213 54.520 1.00 13.55 C

ATOM 5171 CD LYS B 296 4.548 61.365 54.671 1.00 15.03 C

ATOM 5172 CE LYS B 296 3.795 62.661 54.984 1.00 15.04 C

ATOM 5173 NZ LYS B 296 4.684 63.851 55.083 1.00 15.39 N

ATOM 5174 C LYS B 296 5.505 57.079 53.192 1.00 12.37 C

ATOM 5175 O LYS B 296 5.507 56.422 54.245 1.00 12.45 O

ATOM 5176 N GLU B 297 5.873 56.559 52.021 1.00 12.11 N

ATOM 5177 CA GLU B 297 6.181 55.131 51.889 1.00 11.90 C

ATOM 5178 CB GLU B 297 5.294 54.487 50.806 1.00 12.22 C

ATOM 5179 CG GLU B 297 3.797 54.657 51.058 1.00 12.67 C

ATOM 5180 CD GLU B 297 2.903 54.128 49.944 1.00 13.49 C

ATOM 5181 OEl GLU B 297 3.304 53.191 49.225 1.00 14.44 O

ATOM 5182 OE2 GLU B 297 1.777 54.652 49.800 1.00 14.54 O

ATOM 5183 C GLU B 297 7.664 54.860 51.611 1.00 11.63 C

ATOM 5184 O GLU B 297 8.173 55.217 50.545 1.00 11.46 O

ATOM 5185 N SER B 298 8.344 54.231 52.574 1.00 11.00 N

ATOM 5186 CA SER B 298 9.743 53.812 52.409 1.00 11.30 C

ATOM 5187 CB SER B 298 10.202 52.882 53.547 1.00 10.82 C

ATOM 5188 OG SER B 298 10.525 53.603 54.718 1.00 14.16 O

ATOM 5189 C SER B 298 9.926 53.089 51.088 1.00 10.63 C

ATOM 5190 O SER B 298 9.160 52.177 50.766 1.00 11.06 O

ATOM 5191 N GLY B 299 10.923 53.520 50.317 1.00 10.56 N

ATOM 5192 CA GLY B 299 11.323 52.818 49.105 1.00 10.21 C

ATOM 5193 C GLY B 299 10.382 52.978 47.924 1.00 10.03 C

ATOM 5194 O GLY B 299 10.549 52.315 46.895 1.00 9.96 O

ATOM 5195 N ILE B 300 9.407 53.869 48.067 1.00 9.75 N

ATOM 5196 CA ILE B 300 8.346 54.044 47.071 1.00 9.78 C

ATOM 5197 CB ILE B 300 7.018 53.374 47.548 1.00 9.82 C

ATOM 5198 CGl ILE B 300 7.182 51.858 47.754 1.00 9.97 C

ATOM 5199 CDl ILE B 300 7.338 51.056 46.492 1.00 8.97 C

ATOM 5200 CG2 ILE B 300 5.845 53.704 46.606 1.00 10.79 C

ATOM 5201 C ILE B 300 8.069 55.524 46.833 1.00 9.38 C

ATOM 5202 O ILE B 300 7.908 56.294 47.788 1.00 9.53 O

ATOM 5203 N TRP B 301 7.993 55.917 45.562 1.00 9.13 N

ATOM 5204 CA TRP B 301 7.474 57.239 45.206 1.00 8.95 C

ATOM 5205 CB TRP B 301 8.555 58.115 44.564 1.00 9.27 C

ATOM 5206 CG TRP B 301 9.559 58.727 45.514 1.00 9.89 C

ATOM 5207 CDl TRP B 301 9.426 58.905 46.866 1.00 9.90 C

ATOM 5208 NEl TRP B 301 10.549 59.521 47.379 1.00 10.76 N

ATOM 5209 CE2 TRP B 301 11.421 59.777 46.351 1.00 10.18 C

ATOM 5210 CD2 TRP B 301 10.826 59.292 45.159 1.00 9.65 C

ATOM 5211 CE3 TRP B 301 11.526 59.424 43.952 1.00 10.52 C

ATOM 5212 CZ3 TRP B 301 12.782 60.028 43.968 1.00 11.36 C

ATOM 5213 CH2 TRP B 301 13.347 60.499 45.169 1.00 11.11 C

ATOM 5214 CZ2 TRP B 301 12.687 60.379 46.367 1.00 11.17 C

ATOM 5215 C TRP B 301 6.285 57.122 44.253 1.00 8.77 C

ATOM 5216 O TRP B 301 6.354 56.407 43.240 1.00 8.39 O

ATOM 5217 N ALA B 302 5.201 57.822 44.586 1.00 8.36 N

ATOM 5218 CA ALA B 302 4.076 58.006 43.666 1.00 8.28 C

ATOM 5219 CB ALA B 302 2.992 58.868 44.311 1.00 8.32 C

ATOM 5220 C ALA B 302 4.603 58.693 42.418 1.00 8.35 C

ATOM 5221 O ALA B 302 5.605 59.410 42.487 1.00 8.43 O W2025-7029WO / AM102903-PCT

ATOM 5222 N TYR B 303 3.946 58.472 41.280 1.00 8.52 N

ATOM 5223 CA TYR B 303 4.367 59.111 40.035 1.00 8.93 C

ATOM 5224 CB TYR B 303 3.399 58.790 38.888 1.00 9.27 C

ATOM 5225 CG TYR B 303 3.808 59.386 37.559 1.00 9.02 C

ATOM 5226 CDl TYR B 303 5.059 59.104 36.997 1.00 9.48 C

ATOM 5227 CEl TYR B 303 5.436 59.644 35.763 1.00 10.40 C

ATOM 5228 CZ TYR B 303 4.553 60.473 35.084 1.00 10.64 C

ATOM 5229 OH TYR B 303 4.918 61.008 33.868 1.00 11.13 O

ATOM 5230 CE2 TYR B 303 3.304 60.765 35.622 1.00 10.44 C

ATOM 5231 CD2 TYR B 303 2.942 60.221 36.855 1.00 9.74 C

ATOM 5232 C TYR B 303 4.514 60.618 40.208 1.00 9.14 C

ATOM 5233 O TYR B 303 5.509 61.201 39.772 1.00 9.00 O

ATOM 5234 N TYR B 304 3.538 61.243 40.867 1.00 9.37 N

ATOM 5235 CA TYR B 304 3.592 62.687 41.086 1.00 9.55 C

ATOM 5236 CB TYR B 304 2.255 63.266 41.572 1.00 9.86 C

ATOM 5237 CG TYR B 304 1.762 62.830 42.937 1.00 10.02 C

ATOM 5238 CDl TYR B 304 0.804 61.818 43.065 1.00 10.24 C

ATOM 5239 CEl TYR B 304 0.325 61.429 44.320 1.00 10.65 C

ATOM 5240 CZ TYR B 304 0.790 62.076 45.458 1.00 10.56 C

ATOM 5241 OH TYR B 304 0.333 61.711 46.707 1.00 11.02 O

ATOM 5242 CE2 TYR B 304 1.727 63.093 45.356 1.00 10.22 C

ATOM 5243 CD2 TYR B 304 2.201 63.472 44.100 1.00 10.55 C

ATOM 5244 C TYR B 304 4.775 63.114 41.963 1.00 9.46 C

ATOM 5245 O TYR B 304 5.347 64.179 41.745 1.00 9.18 O

ATOM 5246 N GLU B 305 5.153 62.265 42.922 1.00 9.31 N

ATOM 5247 CA GLU B 305 6.364 62.483 43.718 1.00 9.09 C

ATOM 5248 CB GLU B 305 6.424 61.509 44.909 1.00 9.32 C

ATOM 5249 CG GLU B 305 5.354 61.784 45.985 1.00 9.11 C

ATOM 5250 CD GLU B 305 5.355 60.765 47.117 1.00 9.53 C

ATOM 5251 OEl GLU B 305 5.621 59.571 46.862 1.00 9.01 O

ATOM 5252 OE2 GLU B 305 5.074 61.167 48.269 1.00 10.79 O

ATOM 5253 C GLU B 305 7.617 62.359 42.854 1.00 9.08 C

ATOM 5254 O GLU B 305 8.581 63.101 43.034 1.00 9.24 O

ATOM 5255 N ILE B 306 7.599 61.422 41.910 1.00 8.84 N

ATOM 5256 CA ILE B 306 8.710 61.272 40.974 1.00 8.65 C

ATOM 5257 CB ILE B 306 8.575 59.982 40.121 1.00 8.75 C

ATOM 5258 CGl ILE B 306 8.611 58.757 41.051 1.00 8.06 C

ATOM 5259 CDl ILE B 306 8.363 57.413 40.377 1.00 8.21 C

ATOM 5260 CG2 ILE B 306 9.687 59.901 39.079 1.00 8.46 C

ATOM 5261 C ILE B 306 8.811 62.518 40.103 1.00 8.92 C

ATOM 5262 O ILE B 306 9.910 62.984 39.795 1.00 9.01 O

ATOM 5263 N CYS B 307 7.662 63.073 39.725 1.00 9.32 N

ATOM 5264 CA CYS B 307 7.661 64.298 38.927 1.00 10.12 C

ATOM 5265 CB CYS B 307 6.249 64.647 38.465 1.00 10.19 C

ATOM 5266 SG CYS B 307 5.726 63.527 37.162 1.00 11.88

ATOM 5267 C CYS B 307 8.341 65.479 39.624 1.00 10.31 C

ATOM 5268 O CYS B 307 9.010 66.280 38.964 1.00 10.57 O

ATOM 5269 N THR B 308 8.173 65.587 40.943 1.00 10.25 N

ATOM 5270 CA THR B 308 8.928 66.571 41.734 1.00 10.85 C

ATOM 5271 CB THR B 308 8.525 66.537 43.231 1.00 10.82 C

ATOM 5272 OGl THR B 308 7.123 66.801 43.357 1.00 11.20 O

ATOM 5273 CG2 THR B 308 9.299 67.573 44.039 1.00 11.84 C

ATOM 5274 C THR B 308 10.438 66.350 41.573 1.00 10.71 C

ATOM 5275 O THR B 308 11.185 67.292 41.299 1.00 10.86 O

ATOM 5276 N PHE B 309 10.866 65.097 41.727 1.00 10.73 N

ATOM 5277 CA PHE B 309 12.255 64.663 41.538 1.00 11.03 C

ATOM 5278 CB PHE B 309 12.296 63.132 41.644 1.00 11.22 C

ATOM 5279 CG PHE B 309 13.673 62.534 41.800 1.00 10.91 C

ATOM 5280 CDl PHE B 309 14.523 62.921 42.843 1.00 11.28 C

ATOM 5281 CEl PHE B 309 15.779 62.325 43.001 1.00 12.21 C

ATOM 5282 CZ PHE B 309 16.190 61.319 42.126 1.00 11.26 C

ATOM 5283 CE2 PHE B 309 15.337 60.902 41.098 1.00 11.02 C

ATOM 5284 CD2 PHE B 309 14.084 61.507 40.948 1.00 10.49 C W2025-7029WO / AM102903-PCT

ATOM 5285 C PHE B 309 12.802 65.140 40.191 1.00 11.42 C

ATOM 5286 O PHE B 309 13.882 65.736 40.123 1.00 10.77 O

ATOM 5287 N LEU B 310 12.031 64.909 39.130 1.00 11.84 N

ATOM 5288 CA LEU B 310 12.437 65.289 37.778 1.00 12.50 C

ATOM 5289 CB LEU B 310 11.515 64.642 36.729 1.00 12.54 C

ATOM 5290 CG LEU B 310 11.398 63.113 36.724 1.00 12.23 C

ATOM 5291 CDl LEU B 310 10.402 62.644 35.661 1.00 12.22 C

ATOM 5292 CD2 LEU B 310 12.755 62.438 36.524 1.00 12.53 C

ATOM 5293 C LEU B 310 12.472 66.806 37.600 1.00 13.30 C

ATOM 5294 O LEU B 310 13.412 67.340 37.002 1.00 13.42 O

ATOM 5295 N LYS B 311 11.451 67.484 38.130 1.00 14.20 N

ATOM 5296 CA LYS B 311 11.324 68.945 38.059 1.00 15.59 C

ATOM 5297 CB LYS B 311 10.092 69.399 38.840 1.00 16.05 C

ATOM 5298 CG LYS B 311 9.048 70.095 38.026 1.00 18.43 C

ATOM 5299 CD LYS B 311 7.907 70.535 38.924 1.00 19.88 C

ATOM 5300 CE LYS B 311 6.774 71.087 38.095 1.00 20.69 C

ATOM 5301 NZ LYS B 311 5.470 70.935 38.779 1.00 21.25 N

ATOM 5302 C LYS B 311 12.530 69.670 38.628 1.00 15.68 C

ATOM 5303 O LYS B 311 12.952 70.708 38.106 1.00 16.00 O

ATOM 5304 N ASN B 312 13.071 69.124 39.713 1.00 15.91 N

ATOM 5305 CA ASN B 312 14.166 69.764 40.427 1.00 15.88 C

ATOM 5306 CB ASN B 312 13.921 69.687 41.930 1.00 16.06 C

ATOM 5307 CG ASN B 312 12.807 70.612 42.371 1.00 17.02 C

ATOM 5308 ODl ASN B 312 12.959 71.836 42.350 1.00 17.92 O

ATOM 5309 ND2 ASN B 312 11.676 70.038 42.760 1.00 17.59 N

ATOM 5310 C ASN B 312 15.553 69.261 40.039 1.00 15.70 C

ATOM 5311 O ASN B 312 16.520 69.441 40.784 1.00 15.83 O

ATOM 5312 N GLY B 313 15.642 68.631 38.868 1.00 15.36 N

ATOM 5313 CA GLY B 313 16.928 68.412 38.213 1.00 15.14 C

ATOM 5314 C GLY B 313 17.535 67.025 38.232 1.00 14.72 C

ATOM 5315 O GLY B 313 18.691 66.859 37.841 1.00 15.08 O

ATOM 5316 N ALA B 314 16.773 66.020 38.666 1.00 14.31 N

ATOM 5317 CA ALA B 314 17.262 64.641 38.627 1.00 13.92 C

ATOM 5318 CB ALA B 314 16.217 63.676 39.161 1.00 13.75 C

ATOM 5319 C ALA B 314 17.652 64.263 37.204 1.00 13.85 C

ATOM 5320 O ALA B 314 17.016 64.697 36.237 1.00 13.89 O

ATOM 5321 N THR B 315 18.711 63.472 37.086 1.00 14.04 N

ATOM 5322 CA THR B 315 19.195 63.014 35.793 1.00 14.50 C

ATOM 5323 CB THR B 315 20.646 62.507 35.887 1.00 14.82 C

ATOM 5324 OGl THR B 315 21.472 63.545 36.434 1.00 15.54 O

ATOM 5325 CG2 THR B 315 21.170 62.116 34.514 1.00 14.57 C

ATOM 5326 C THR B 315 18.276 61.908 35.293 1.00 14.74 C

ATOM 5327 O THR B 315 17.982 60.950 36.011 1.00 14.84 O

ATOM 5328 N GLN B 316 17.810 62.060 34.062 1.00 14.74 N

ATOM 5329 CA GLN B 316 16.887 61.099 33.487 1.00 14.75 C

ATOM 5330 CB GLN B 316 15.852 61.819 32.632 1.00 15.15 C

ATOM 5331 CG GLN B 316 14.929 62.712 33.451 1.00 16.36 C

ATOM 5332 CD GLN B 316 13.882 63.410 32.609 1.00 17.83 C

ATOM 5333 OEl GLN B 316 13.452 62.893 31.575 1.00 19.47 O

ATOM 5334 NE2 GLN B 316 13.461 64.590 33.049 1.00 17.91 N

ATOM 5335 C GLN B 316 17.613 60.034 32.682 1.00 14.71 C

ATOM 5336 O GLN B 316 18.555 60.328 31.944 1.00 14.88 O

ATOM 5337 N GLY B 317 17.172 58.792 32.847 1.00 13.65 N

ATOM 5338 CA GLY B 317 17.699 57.680 32.073 1.00 12.90 C

ATOM 5339 C GLY B 317 16.581 56.945 31.366 1.00 12.48 C

ATOM 5340 O GLY B 317 15.415 57.030 31.765 1.00 12.55 O

ATOM 5341 N TRP B 318 16.939 56.238 30.301 1.00 11.86 N

ATOM 5342 CA TRP B 318 16.003 55.346 29.632 1.00 11.43 C

ATOM 5343 CB TRP B 318 15.594 55.875 28.252 1.00 11.34 C

ATOM 5344 CG TRP B 318 14.528 55.031 27.597 1.00 11.26 C

ATOM 5345 CDl TRP B 318 14.697 54.144 26.571 1.00 11.89 C

ATOM 5346 NEl TRP B 318 13.494 53.553 26.248 1.00 12.08 N

ATOM 5347 CE2 TRP B 318 12.519 54.048 27.077 1.00 10.84 C W2025-7029WO / AM102903-PCT

ATOM 5348 CD2 TRP B 318 13.133 54.981 27.945 1.00 11.17 C

ATOM 5349 CE3 TRP B 318 12.344 55.636 28.902 1.00 11.17 C

ATOM 5350 CZ3 TRP B 318 10.982 55.347 28.963 1.00 11.61 C

ATOM 5351 CH2 TRP B 318 10.398 54.413 28.084 1.00 10.73 C

ATOM 5352 CZ2 TRP B 318 11.147 53.754 27.138 1.00 11.12 C

ATOM 5353 C TRP B 318 16.620 53.963 29.531 1.00 11.41 C

ATOM 5354 O TRP B 318 17.738 53.801 29.035 1.00 11.61 O

ATOM 5355 N ASP B 319 15.892 52.980 30.052 1.00 10.92 N

ATOM 5356 CA ASP B 319 16.257 51.579 29.983 1.00 10.89 C

ATOM 5357 CB ASP B 319 15.694 50.891 31.239 1.00 10.66 C

ATOM 5358 CG ASP B 319 16.019 49.402 31.335 1.00 11.22 C

ATOM 5359 ODl ASP B 319 15.777 48.860 32.436 1.00 10.91 O

ATOM 5360 OD2 ASP B 319 16.489 48.770 30.363 1.00 10.62 O

ATOM 5361 C ASP B 319 15.632 51.033 28.692 1.00 10.64 C

ATOM 5362 O ASP B 319 14.489 50.578 28.688 1.00 10.73 O

ATOM 5363 N ALA B 320 16.369 51.110 27.585 1.00 10.55 N

ATOM 5364 CA ALA B 320 15.823 50.706 26.282 1.00 10.54 C

ATOM 5365 CB ALA B 320 16.779 51.084 25.142 1.00 10.48 C

ATOM 5366 C ALA B 320 15.397 49.232 26.168 1.00 10.37 C

ATOM 5367 O ALA B 320 14.329 48.957 25.621 1.00 10.52 O

ATOM 5368 N PRO B 321 16.228 48.278 26.655 1.00 10.44 N

ATOM 5369 CA PRO B 321 15.825 46.871 26.540 1.00 10.29 C

ATOM 5370 CB PRO B 321 16.943 46.125 27.281 1.00 10.49 C

ATOM 5371 CG PRO B 321 18.118 47.029 27.188 1.00 10.89 C

ATOM 5372 CD PRO B 321 17.559 48.407 27.284 1.00 10.64 C

ATOM 5373 C PRO B 321 14.482 46.592 27.212 1.00 10.23 C

ATOM 5374 O PRO B 321 13.688 45.790 26.708 1.00 9.92 O

ATOM 5375 N GLN B 322 14.227 47.285 28.319 1.00 9.66 N

ATOM 5376 CA GLN B 322 13.048 47.019 29.140 1.00 9.50 C

ATOM 5377 CB GLN B 322 13.465 46.916 30.607 1.00 9.39 C

ATOM 5378 CG GLN B 322 14.596 45.909 30.817 1.00 9.27 C

ATOM 5379 CD GLN B 322 14.779 45.527 32.264 1.00 9.74 C

ATOM 5380 OEl GLN B 322 14.440 44.411 32.676 1.00 11.34 O

ATOM 5381 NE2 GLN B 322 15.309 46.445 33.048 1.00 9.02 N

ATOM 5382 C GLN B 322 11.915 48.031 28.946 1.00 9.31 C

ATOM 5383 O GLN B 322 10.827 47.858 29.505 1.00 9.15 O

ATOM 5384 N GLU B 323 12.181 49.063 28.140 1.00 9.40 N

ATOM 5385 CA GLU B 323 11.199 50.094 27.754 1.00 9.55 C

ATOM 5386 CB GLU B 323 10.091 49.501 26.865 1.00 9.71 C

ATOM 5387 CG GLU B 323 10.597 48.875 25.571 1.00 12.18 C

ATOM 5388 CD GLU B 323 11.052 49.886 24.523 1.00 14.68 C

ATOM 5389 OEl GLU B 323 11.224 49.464 23.363 1.00 17.09 O

ATOM 5390 OE2 GLU B 323 11.245 51.086 24.831 1.00 15.92 O

ATOM 5391 C GLU B 323 10.610 50.865 28.938 1.00 9.20 C

ATOM 5392 O GLU B 323 9.415 51.184 28.967 1.00 9.02 O

ATOM 5393 N VAL B 324 11.463 51.175 29.909 1.00 9.10 N

ATOM 5394 CA VAL B 324 11.026 51.919 31.089 1.00 8.93 C

ATOM 5395 CB VAL B 324 10.728 50.985 32.279 1.00 8.97 C

ATOM 5396 CGl VAL B 324 9.317 50.389 32.157 1.00 8.47 C

ATOM 5397 CG2 VAL B 324 11.776 49.886 32.374 1.00 8.84 C

ATOM 5398 C VAL B 324 12.054 52.972 31.491 1.00 9.30 C

ATOM 5399 O VAL B 324 13.246 52.792 31.240 1.00 9.20 O

ATOM 5400 N PRO B 325 11.590 54.084 32.092 1.00 9.53 N

ATOM 5401 CA PRO B 325 12.525 55.127 32.523 1.00 9.74 C

ATOM 5402 CB PRO B 325 11.629 56.359 32.621 1.00 9.88 C

ATOM 5403 CG PRO B 325 10.303 55.790 33.079 1.00 10.03 C

ATOM 5404 CD PRO B 325 10.187 54.450 32.377 1.00 9.48 C

ATOM 5405 C PRO B 325 13.114 54.844 33.893 1.00 9.96 C

ATOM 5406 O PRO B 325 12.554 54.064 34.666 1.00 9.85 O

ATOM 5407 N TYR B 326 14.242 55.487 34.176 1.00 10.20 N

ATOM 5408 CA TYR B 326 14.750 55.607 35.533 1.00 10.78 C

ATOM 5409 CB TYR B 326 15.772 54.510 35.857 1.00 10.90 C

ATOM 5410 CG TYR B 326 17.042 54.518 35.028 1.00 12.12 C W2025-7029WO / AM102903-PCT

ATOM 5411 CDl TYR B 326 18.193 55.171 35.483 1.00 13.01 C

ATOM 5412 CEl TYR B 326 19.369 55.168 34.727 1.00 13.94 C

ATOM 5413 CZ TYR B 326 19.404 54.496 33.512 1.00 14.48 C

ATOM 5414 OH TYR B 326 20.567 54.482 32.766 1.00 16.15 O

ATOM 5415 CE2 TYR B 326 18.282 53.830 33.047 1.00 13.68 C

ATOM 5416 CD2 TYR B 326 17.107 53.844 33.805 1.00 12.62 C

ATOM 5417 C TYR B 326 15.335 57.001 35.714 1.00 10.97 C

ATOM 5418 O TYR B 326 15.530 57.733 34.738 1.00 10.51 O

ATOM 5419 N ALA B 327 15.600 57.373 36.962 1.00 11.03 N

ATOM 5420 CA ALA B 327 16.152 58.686 37.256 1.00 11.29 C

ATOM 5421 CB ALA B 327 15.037 59.707 37.437 1.00 11.21 C

ATOM 5422 C ALA B 327 17.014 58.608 38.503 1.00 11.65 C

ATOM 5423 O ALA B 327 16.789 57.768 39.370 1.00 11.47 O

ATOM 5424 N TYR B 328 18.008 59.485 38.587 1.00 12.11 N

ATOM 5425 CA TYR B 328 18.885 59.499 39.747 1.00 12.65 C

ATOM 5426 CB TYR B 328 20.056 58.522 39.573 1.00 12.92 C

ATOM 5427 CG TYR B 328 20.911 58.787 38.358 1.00 13.86 C

ATOM 5428 CDl TYR B 328 20.598 58.211 37.127 1.00 15.37 C

ATOM 5429 CEl TYR B 328 21.375 58.447 36.007 1.00 15.86 C

ATOM 5430 CZ TYR B 328 22.489 59.262 36.113 1.00 16.82 C

ATOM 5431 OH TYR B 328 23.259 59.490 34.993 1.00 17.97 O

ATOM 5432 CE2 TYR B 328 22.829 59.844 37.324 1.00 15.81 C

ATOM 5433 CD2 TYR B 328 22.040 59.606 38.441 1.00 15.19 C

ATOM 5434 C TYR B 328 19.390 60.895 40.055 1.00 12.88 C

ATOM 5435 O TYR B 328 19.440 61.755 39.176 1.00 13.21 O

ATOM 5436 N GLN B 329 19.735 61.106 41.320 1.00 13.11 N

ATOM 5437 CA GLN B 329 20.341 62.351 41.774 1.00 13.64 C

ATOM 5438 CB GLN B 329 19.277 63.424 41.975 1.00 13.48 C

ATOM 5439 CG GLN B 329 19.841 64.802 42.279 1.00 14.75 C

ATOM 5440 CD GLN B 329 18.773 65.867 42.280 1.00 15.90 C

ATOM 5441 OEl GLN B 329 18.836 66.824 41.505 1.00 18.77 O

ATOM 5442 NE2 GLN B 329 17.777 65.705 43.140 1.00 16.37 N

ATOM 5443 C GLN B 329 21.048 62.060 43.086 1.00 13.99 C

ATOM 5444 O GLN B 329 20.444 61.508 44.003 1.00 13.47 O

ATOM 5445 N GLY B 330 22.320 62.442 43.176 1.00 14.45 N

ATOM 5446 CA GLY B 330 23.130 62.112 44.350 1.00 15.02 C

ATOM 5447 C GLY B 330 23.093 60.613 44.601 1.00 15.15 C

ATOM 5448 O GLY B 330 23.405 59.826 43.706 1.00 15.52 O

ATOM 5449 N ASN B 331 22.683 60.221 45.809 1.00 15.42 N

ATOM 5450 CA ASN B 331 22.618 58.804 46.180 1.00 15.31 C

ATOM 5451 CB ASN B 331 23.150 58.565 47.614 1.00 15.83 C

ATOM 5452 CG ASN B 331 22.174 58.999 48.728 1.00 17.70 C

ATOM 5453 ODl ASN B 331 21.201 59.728 48.508 1.00 19.91 O

ATOM 5454 ND2 ASN B 331 22.465 58.553 49.950 1.00 19.79 N

ATOM 5455 C ASN B 331 21.257 58.129 45.966 1.00 14.77 C

ATOM 5456 O ASN B 331 21.044 57.006 46.423 1.00 15.06 O

ATOM 5457 N VAL B 332 20.346 58.809 45.272 1.00 13.89 N

ATOM 5458 CA VAL B 332 18.997 58.279 45.078 1.00 13.03 C

ATOM 5459 CB VAL B 332 17.906 59.255 45.581 1.00 13.12 C

ATOM 5460 CGl VAL B 332 16.523 58.629 45.454 1.00 13.31 C

ATOM 5461 CG2 VAL B 332 18.171 59.655 47.029 1.00 13.47 C

ATOM 5462 C VAL B 332 18.738 57.912 43.621 1.00 12.52 C

ATOM 5463 O VAL B 332 19.040 58.684 42.713 1.00 12.54 O

ATOM 5464 N TRP B 333 18.166 56.727 43.428 1.00 11.70 N

ATOM 5465 CA TRP B 333 17.883 56.162 42.113 1.00 10.84 C

ATOM 5466 CB TRP B 333 18.844 55.008 41.841 1.00 10.72 C

ATOM 5467 CG TRP B 333 18.884 54.445 40.424 1.00 10.59 C

ATOM 5468 CDl TRP B 333 19.781 54.769 39.446 1.00 10.98 C

ATOM 5469 NEl TRP B 333 19.538 54.030 38.309 1.00 10.67 N

ATOM 5470 CE2 TRP B 333 18.469 53.204 38.535 1.00 10.68 C

ATOM 5471 CD2 TRP B 333 18.033 53.428 39.863 1.00 10.66 C

ATOM 5472 CE3 TRP B 333 16.943 52.691 40.352 1.00 9.82 C

ATOM 5473 CZ3 TRP B 333 16.324 51.763 39.501 1.00 9.64 C W2025-7029WO / AM102903-PCT

ATOM 5474 CH2 TRP B 333 16.785 51.563 38.184 1.00 10.25 C

ATOM 5475 CZ2 TRP B 333 17.850 52.269 37.682 1.00 10.39 C

ATOM 5476 C TRP B 333 16.466 55.630 42.182 1.00 10.19 C

ATOM 5477 O TRP B 333 16.094 54.992 43.170 1.00 10.12 O

ATOM 5478 N VAL B 334 15.681 55.904 41.144 1.00 9.66 N

ATOM 5479 CA VAL B 334 14.301 55.427 41.075 1.00 8.70 C

ATOM 5480 CB VAL B 334 13.275 56.577 41.364 1.00 9.18 C

ATOM 5481 CGl VAL B 334 13.356 57.681 40.316 1.00 9.33 C

ATOM 5482 CG2 VAL B 334 11.847 56.041 41.485 1.00 8.38 C

ATOM 5483 C VAL B 334 14.023 54.742 39.734 1.00 8.61 C

ATOM 5484 O VAL B 334 14.376 55.262 38.672 1.00 8.11 O

ATOM 5485 N GLY B 335 13.422 53.557 39.811 1.00 7.96 N

ATOM 5486 CA GLY B 335 12.940 52.823 38.639 1.00 7.92 C

ATOM 5487 C GLY B 335 11.438 52.963 38.618 1.00 7.83 C

ATOM 5488 O GLY B 335 10.771 52.711 39.629 1.00 7.63 O

ATOM 5489 N TYR B 336 10.894 53.400 37.484 1.00 7.61 N

ATOM 5490 CA TYR B 336 9.484 53.785 37.447 1.00 7.49 C

ATOM 5491 CB TYR B 336 9.310 55.191 38.046 1.00 7.53 C

ATOM 5492 CG TYR B 336 9.849 56.319 37.195 1.00 7.35 C

ATOM 5493 CDl TYR B 336 11.224 56.562 37.105 1.00 7.60 C

ATOM 5494 CEl TYR B 336 11.722 57.597 36.318 1.00 7.68 C

ATOM 5495 CZ TYR B 336 10.834 58.413 35.622 1.00 7.45 C

ATOM 5496 OH TYR B 336 11.318 59.436 34.841 1.00 7.85 O

ATOM 5497 CE2 TYR B 336 9.466 58.201 35.702 1.00 6.98 C

ATOM 5498 CD2 TYR B 336 8.980 57.156 36.485 1.00 7.79 C

ATOM 5499 C TYR B 336 8.834 53.672 36.057 1.00 7.80 C

ATOM 5500 O TYR B 336 9.408 53.089 35.140 1.00 7.38 O

ATOM 5501 N ASP B 337 7.621 54.206 35.938 1.00 7.99 N

ATOM 5502 CA ASP B 337 6.888 54.249 34.674 1.00 8.37 C

ATOM 5503 CB ASP B 337 5.706 53.292 34.709 1.00 8.30 C

ATOM 5504 CG ASP B 337 6.090 51.891 34.322 1.00 8.80 C

ATOM 5505 ODl ASP B 337 6.451 51.112 35.226 1.00 7.79 O

ATOM 5506 OD2 ASP B 337 6.057 51.582 33.110 1.00 8.89 O

ATOM 5507 C ASP B 337 6.386 55.655 34.403 1.00 8.39 C

ATOM 5508 O ASP B 337 5.988 56.368 35.328 1.00 8.19 O

ATOM 5509 N ASN B 338 6.422 56.049 33.128 1.00 8.43 N

ATOM 5510 CA ASN B 338 5.915 57.344 32.705 1.00 8.60 C

ATOM 5511 CB ASN B 338 7.065 58.314 32.372 1.00 8.74 C

ATOM 5512 CG ASN B 338 7.992 57.804 31.262 1.00 8.34 C

ATOM 5513 ODl ASN B 338 7.711 56.812 30.583 1.00 8.90 O

ATOM 5514 ND2 ASN B 338 9.105 58.506 31.068 1.00 9.19 N

ATOM 5515 C ASN B 338 4.925 57.203 31.546 1.00 8.91 C

ATOM 5516 O ASN B 338 4.481 56.097 31.238 1.00 9.14 O

ATOM 5517 N VAL B 339 4.568 58.321 30.920 1.00 9.40 N

ATOM 5518 CA VAL B 339 3.634 58.294 29.793 1.00 9.50 C

ATOM 5519 CB VAL B 339 3.303 59.725 29.288 1.00 9.78 C

ATOM 5520 CGl VAL B 339 2.599 59.686 27.930 1.00 9.78 C

ATOM 5521 CG2 VAL B 339 2.448 60.457 30.321 1.00 9.02 C

ATOM 5522 C VAL B 339 4.170 57.399 28.666 1.00 9.63 C

ATOM 5523 O VAL B 339 3.435 56.569 28.130 1.00 9.55 O

ATOM 5524 N LYS B 340 5.452 57.559 28.335 1.00 9.82 N

ATOM 5525 CA LYS B 340 6.090 56.781 27.265 1.00 10.28 C

ATOM 5526 CB LYS B 340 7.532 57.261 27.046 1.00 10.35 C

ATOM 5527 CG LYS B 340 8.247 56.631 25.852 1.00 12.09 C

ATOM 5528 CD LYS B 340 9.635 57.261 25.656 1.00 14.30 C

ATOM 5529 CE LYS B 340 10.459 56.505 24.613 1.00 16.88 C

ATOM 5530 NZ LYS B 340 11.836 57.086 24.456 1.00 18.17 N

ATOM 5531 C LYS B 340 6.050 55.265 27.515 1.00 9.86 C

ATOM 5532 O LYS B 340 5.672 54.495 26.622 1.00 9.61 O

ATOM 5533 N SER B 341 6.429 54.840 28.720 1.00 9.39 N

ATOM 5534 CA SER B 341 6.481 53.414 29.037 1.00 9.20 C

ATOM 5535 CB SER B 341 7.282 53.151 30.321 1.00 9.27 C

ATOM 5536 OG SER B 341 6.583 53.609 31.458 1.00 8.93 O W2025-7029WO / AM102903-PCT

ATOM 5537 C SER B 341 5.076 52.812 29.129 1.00 8.95 C

ATOM 5538 O SER B 341 4.864 51.672 28.722 1.00 9.10 O

ATOM 5539 N PHE B 342 4.122 53.581 29.660 1.00 9.13 N

ATOM 5540 CA PHE B 342 2.728 53.137 29.720 1.00 9.39 C

ATOM 5541 CB PHE B 342 1.852 54.140 30.487 1.00 9.19 C

ATOM 5542 CG PHE B 342 1.612 53.770 31.934 1.00 9.47 C

ATOM 5543 CDl PHE B 342 2.638 53.246 32.721 1.00 9.92 C

ATOM 5544 CEl PHE B 342 2.413 52.905 34.060 1.00 9.56 C

ATOM 5545 CZ PHE B 342 1.158 53.103 34.628 1.00 10.07 C

ATOM 5546 CE2 PHE B 342 0.124 53.624 33.851 1.00 8.57 C

ATOM 5547 CD2 PHE B 342 0.359 53.962 32.512 1.00 9.49 C

ATOM 5548 C PHE B 342 2.185 52.909 28.311 1.00 9.71 C

ATOM 5549 O PHE B 342 1.546 51.890 28.044 1.00 9.68 O

ATOM 5550 N ASP B 343 2.468 53.847 27.409 1.00 10.28 N

ATOM 5551 CA ASP B 343 2.040 53.720 26.017 1.00 10.61 C

ATOM 5552 CB ASP B 343 2.372 54.981 25.223 1.00 11.08 C

ATOM 5553 CG ASP B 343 1.796 54.949 23.822 1.00 13.03 C

ATOM 5554 ODl ASP B 343 2.587 54.996 22.862 1.00 16.86 O

ATOM 5555 OD2 ASP B 343 0.558 54.850 23.683 1.00 16.65 O

ATOM 5556 C ASP B 343 2.661 52.492 25.347 1.00 10.62 C

ATOM 5557 O ASP B 343 1.959 51.726 24.685 1.00 10.27 O

ATOM 5558 N ILE B 344 3.968 52.304 25.540 1.00 10.55 N

ATOM 5559 CA ILE B 344 4.683 51.160 24.965 1.00 10.65 C

ATOM 5560 CB ILE B 344 6.203 51.224 25.266 1.00 10.39 C

ATOM 5561 CGl ILE B 344 6.836 52.388 24.490 1.00 10.88 C

ATOM 5562 CDl ILE B 344 8.218 52.803 24.986 1.00 10.56 C

ATOM 5563 CG2 ILE B 344 6.897 49.914 24.879 1.00 10.73 C

ATOM 5564 C ILE B 344 4.055 49.837 25.418 1.00 10.73 C

ATOM 5565 O ILE B 344 3.771 48.952 24.595 1.00 10.92 O

ATOM 5566 N LYS B 345 3.802 49.721 26.722 1.00 10.72 N

ATOM 5567 CA LYS B 345 3.158 48.533 27.275 1.00 10.94 C

ATOM 5568 CB LYS B 345 3.119 48.600 28.794 1.00 11.20 C

ATOM 5569 CG LYS B 345 4.435 48.342 29.462 1.00 13.27 C

ATOM 5570 CD LYS B 345 4.393 48.909 30.863 1.00 14.80 C

ATOM 5571 CE LYS B 345 5.722 48.804 31.539 1.00 14.43 C

ATOM 5572 NZ LYS B 345 5.524 48.909 32.995 1.00 14.55 N

ATOM 5573 C LYS B 345 1.743 48.339 26.743 1.00 10.92 C

ATOM 5574 O LYS B 345 1.331 47.209 26.494 1.00 10.78 O

ATOM 5575 N ALA B 346 1.002 49.437 26.583 1.00 10.67 N

ATOM 5576 CA ALA B 346 0.372 49.364 26.090 1.00 10.72 C

ATOM 5577 CB ALA B 346 1.056 50.725 26.178 1.00 10.69 C

ATOM 5578 C ALA B 346 0.400 48.828 24.661 1.00 10.54 C

ATOM 5579 O ALA B 346 1.226 47.980 24.327 1.00 10.54 O

ATOM 5580 N GLN B 347 0.519 49.307 23.825 1.00 10.75 N

ATOM 5581 CA GLN B 347 0.623 48.796 22.455 1.00 10.80 C

ATOM 5582 CB GLN B 347 1.646 49.581 21.627 1.00 11.09 C

ATOM 5583 CG GLN B 347 1.494 51.115 21.649 1.00 11.60 C

ATOM 5584 CD GLN B 347 0.111 51.622 21.242 1.00 13.50 C

ATOM 5585 OEl GLN B 347 0.561 51.037 20.392 1.00 13.37 O

ATOM 5586 NE2 GLN B 347 0.305 52.735 21.842 1.00 13.47 N

ATOM 5587 C GLN B 347 0.969 47.307 22.467 1.00 10.78 C

ATOM 5588 O GLN B 347 0.396 46.521 21.707 1.00 10.37 O

ATOM 5589 N TRP B 348 1.895 46.923 23.344 1.00 10.76 N

ATOM 5590 CA TRP B 348 2.296 45.521 23.489 1.00 11.11 C

ATOM 5591 CB TRP B 348 3.439 45.396 24.510 1.00 11.10 C

ATOM 5592 CG TRP B 348 3.774 43.985 24.900 1.00 11.29 C

ATOM 5593 CDl TRP B 348 4.669 43.152 24.287 1.00 11.67 C

ATOM 5594 NEl TRP B 348 4.713 41.941 24.938 1.00 11.89 N

ATOM 5595 CE2 TRP B 348 3.837 41.969 25.992 1.00 11.95 C

ATOM 5596 CD2 TRP B 348 3.226 43.241 26.002 1.00 11.35 C

ATOM 5597 CE3 TRP B 348 2.283 43.533 26.999 1.00 12.91 C

ATOM 5598 CZ3 TRP B 348 1.976 42.546 27.940 1.00 12.41 C

ATOM 5599 CH2 TRP B 348 2.599 41.289 27.895 1.00 12.29 C W2025-7029WO / AM102903-PCT

ATOM 5600 CZ2 TRP B 348 3.525 40.980 26.933 1.00 11.78 C

ATOM 5601 C TRP B 348 1.109 44.654 23.912 1.00 11.31 C

ATOM 5602 O TRP B 348 0.907 43.554 23.392 1.00 11.36 O

ATOM 5603 N LEU B 349 0.336 45.174 24.862 1.00 11.50 N

ATOM 5604 CA LEU B 349 0.853 44.510 25.385 1.00 12.02 C

ATOM 5605 CB LEU B 349 1.515 45.450 26.393 1.00 12.42 C

ATOM 5606 CG LEU B 349 2.648 45.064 27.325 1.00 13.10 C

ATOM 5607 CDl LEU B 349 2.705 46.136 28.390 1.00 12.77 C

ATOM 5608 CD2 LEU B 349 3.989 44.943 26.610 1.00 12.23 C

ATOM 5609 C LEU B 349 1.829 44.194 24.250 1.00 11.88 C

ATOM 5610 O LEU B 349 2.333 43.071 24.137 1.00 11.59 O

ATOM 5611 N LYS B 350 2.083 45.202 23.417 1.00 12.00 N

ATOM 5612 CA LYS B 350 2.962 45.062 22.251 1.00 12.42 C

ATOM 5613 CB LYS B 350 3.140 46.409 21.545 1.00 12.57 C

ATOM 5614 CG LYS B 350 3.878 47.473 22.365 1.00 12.82 C

ATOM 5615 CD LYS B 350 4.325 48.651 21.497 1.00 14.22 C

ATOM 5616 CE LYS B 350 3.141 49.409 20.921 1.00 14.83 C

ATOM 5617 NZ LYS B 350 3.519 50.723 20.320 1.00 14.66 N

ATOM 5618 C LYS B 350 2.439 44.019 21.263 1.00 12.30 C

ATOM 5619 O LYS B 350 3.204 43.194 20.747 1.00 12.30 O

ATOM 5620 N HIS B 351 1.134 44.053 21.003 1.00 12.22 N

ATOM 5621 CA HIS B 351 0.526 43.140 20.033 1.00 12.61 C

ATOM 5622 CB HIS B 351 0.923 43.527 19.752 1.00 12.63 C

ATOM 5623 CG HIS B 351 1.084 44.939 19.283 1.00 13.40 C

ATOM 5624 NDl HIS B 351 2.221 45.676 19.528 1.00 13.79 N

ATOM 5625 CEl HIS B 351 2.079 46.886 19.015 1.00 13.20 C

ATOM 5626 NE2 HIS B 351 0.883 46.966 18.460 1.00 13.74 N

ATOM 5627 CD2 HIS B 351 0.236 45.765 18.621 1.00 13.84 C

ATOM 5628 C HIS B 351 0.633 41.695 20.496 1.00 12.75 C

ATOM 5629 O HIS B 351 0.751 40.779 19.679 1.00 12.94 O

ATOM 5630 N ASN B 352 0.623 41.512 21.814 1.00 12.64 N

ATOM 5631 CA ASN B 352 0.761 40.196 22.420 1.00 12.70 C

ATOM 5632 CB ASN B 352 0.126 40.099 23.660 1.00 12.85 C

ATOM 5633 CG ASN B 352 1.586 39.964 23.308 1.00 13.05 C

ATOM 5634 ODl ASN B 352 2.105 38.852 23.214 1.00 14.90 O

ATOM 5635 ND2 ASN B 352 2.254 41.092 23.072 1.00 13.42 N

ATOM 5636 C ASN B 352 2.212 39.819 22.735 1.00 12.61 C

ATOM 5637 O ASN B 352 2.490 38.698 23.171 1.00 12.58 O

ATOM 5638 N LYS B 353 3.123 40.765 22.501 1.00 12.52 N

ATOM 5639 CA LYS B 353 4.574 40.551 22.616 1.00 12.42 C

ATOM 5640 CB LYS B 353 5.081 39.595 21.515 1.00 12.39 C

ATOM 5641 CG LYS B 353 4.722 40.051 20.104 1.00 13.71 C

ATOM 5642 CD LYS B 353 5.052 39.003 19.061 1.00 15.42 C

ATOM 5643 CE LYS B 353 4.593 39.452 17.675 1.00 17.77 C

ATOM 5644 NZ LYS B 353 4.675 38.331 16.687 1.00 19.89 N

ATOM 5645 C LYS B 353 5.018 40.089 24.011 1.00 11.97 C

ATOM 5646 O LYS B 353 5.887 39.226 24.149 1.00 12.21 O

ATOM 5647 N PHE B 354 4.410 40.663 25.046 1.00 11.40 N

ATOM 5648 CA PHE B 354 4.878 40.433 26.413 1.00 10.94 C

ATOM 5649 CB PHE B 354 3.786 40.777 27.433 1.00 10.95 C

ATOM 5650 CG PHE B 354 2.615 39.826 27.405 1.00 10.88 C

ATOM 5651 CDl PHE B 354 1.340 40.274 27.063 1.00 11.88 C

ATOM 5652 CEl PHE B 354 0.258 39.390 27.033 1.00 10.12 C

ATOM 5653 CZ PHE B 354 0.450 38.052 27.331 1.00 10.78 C

ATOM 5654 CE2 PHE B 354 1.717 37.590 27.667 1.00 11.01 C

ATOM 5655 CD2 PHE B 354 2.788 38.476 27.700 1.00 11.23 C

ATOM 5656 C PHE B 354 6.171 41.206 26.680 1.00 10.76 C

ATOM 5657 O PHE B 354 6.588 42.031 25.861 1.00 10.88 O

ATOM 5658 N GLY B 355 6.805 40.934 27.819 1.00 10.25 N

ATOM 5659 CA GLY B 355 8.109 41.513 28.138 1.00 10.23 C

ATOM 5660 C GLY B 355 8.119 43.005 28.414 1.00 9.99 C

ATOM 5661 O GLY B 355 9.160 43.656 28.305 1.00 10.67 O

ATOM 5662 N GLY B 356 6.964 43.545 28.784 1.00 9.74 N W2025-7029WO / AM102903-PCT

ATOM 5663 CA GLY B 356 6.845 44.957 29.111 1.00 9.33 C

ATOM 5664 C GLY B 356 5.792 45.217 30.168 1.00 9.12 C

ATOM 5665 O GLY B 356 4.871 44.414 30.353 1.00 9.04 O

ATOM 5666 N ALA B 357 5.947 46.341 30.860 1.00 8.76 N

ATOM 5667 CA ALA B 357 4.968 46.819 31.835 1.00 8.55 C

ATOM 5668 CB ALA B 357 4.294 48.072 31.314 1.00 8.47 C

ATOM 5669 C ALA B 357 5.622 47.120 33.177 1.00 8.56 C

ATOM 5670 O ALA B 357 6.769 47.564 33.225 1.00 8.89 O

ATOM 5671 N MET B 358 4.892 46.874 34.263 1.00 8.24 N

ATOM 5672 CA MET B 358 5.297 47.376 35.577 1.00 8.27 C

ATOM 5673 CB MET B 358 5.694 46.249 36.550 1.00 8.28 C

ATOM 5674 CG MET B 358 4.582 45.291 36.956 1.00 8.39 C

ATOM 5675 SD MET B 358 3.547 45.946 38.286 1.00 9.35 S

ATOM 5676 CE MET B 358 2.777 44.427 38.835 1.00 9.84 C

ATOM 5677 C MET B 358 4.218 48.296 36.136 1.00 8.31 C

ATOM 5678 O MET B 358 3.041 48.195 35.768 1.00 8.35 O

ATOM 5679 N VAL B 359 4.632 49.221 36.994 1.00 7.89 N

ATOM 5680 CA VAL B 359 3.746 50.276 37.462 1.00 8.16 C

ATOM 5681 CB VAL B 359 4.153 51.653 36.878 1.00 8.37 C

ATOM 5682 CGl VAL B 359 3.231 52.741 37.377 1.00 8.39 C

ATOM 5683 CG2 VAL B 359 4.155 51.616 35.348 1.00 8.10 C

ATOM 5684 C VAL B 359 3.739 50.348 38.979 1.00 8.37 C

ATOM 5685 O VAL B 359 4.780 50.534 39.614 1.00 8.23 O

ATOM 5686 N TRP B 360 2.555 50.180 39.552 1.00 8.31 N

ATOM 5687 CA TRP B 360 2.355 50.446 40.962 1.00 8.51 C

ATOM 5688 CB TRP B 360 1.719 49.250 41.677 1.00 8.59 C

ATOM 5689 CG TRP B 360 1.657 49.477 43.156 1.00 8.93 C

ATOM 5690 CDl TRP B 360 0.704 50.179 43.845 1.00 9.30 C

ATOM 5691 NEl TRP B 360 1.012 50.199 45.189 1.00 9.16 N

ATOM 5692 CE2 TRP B 360 2.181 49.513 45.385 1.00 8.28 C

ATOM 5693 CD2 TRP B 360 2.620 49.050 44.124 1.00 8.23 C

ATOM 5694 CE3 TRP B 360 3.806 48.310 44.050 1.00 7.86 C

ATOM 5695 CZ3 TRP B 360 4.508 48.051 45.224 1.00 9.07 C

ATOM 5696 CH2 TRP B 360 4.042 48.521 46.468 1.00 9.24 C

ATOM 5697 CZ2 TRP B 360 2.886 49.251 46.569 1.00 7.95 C

ATOM 5698 C TRP B 360 1.445 51.672 41.062 1.00 8.41 C

ATOM 5699 O TRP B 360 0.276 51.588 40.687 1.00 8.21 O

ATOM 5700 N ALA B 361 1.949 52.813 41.536 1.00 8.42 N

ATOM 5701 CA ALA B 361 3.344 53.039 41.923 1.00 8.75 C

ATOM 5702 CB ALA B 361 3.487 52.996 43.439 1.00 8.49 C

ATOM 5703 C ALA B 361 3.738 54.421 41.397 1.00 8.87 C

ATOM 5704 O ALA B 361 2.866 55.260 41.125 1.00 8.90 O

ATOM 5705 N ILE B 362 5.039 54.669 41.270 1.00 9.04 N

ATOM 5706 CA ILE B 362 5.524 55.937 40.704 1.00 9.71 C

ATOM 5707 CB ILE B 362 7.070 55.920 40.533 1.00 9.87 C

ATOM 5708 CGl ILE B 362 7.552 57.147 39.748 1.00 10.52 C

ATOM 5709 CDl ILE B 362 8.915 56.975 39.110 1.00 11.24 C

ATOM 5710 CG2 ILE B 362 7.790 55.780 41.882 1.00 10.67 C

ATOM 5711 C ILE B 362 5.034 57.155 41.517 1.00 9.62 C

ATOM 5712 O ILE B 362 4.706 58.206 40.958 1.00 10.11 O

ATOM 5713 N ASP B 363 4.953 56.984 42.835 1.00 9.94 N

ATOM 5714 CA ASP B 363 4.509 58.048 43.740 1.00 9.73 C

ATOM 5715 CB ASP B 363 4.982 57.763 45.172 1.00 9.95 C

ATOM 5716 CG ASP B 363 4.567 56.385 45.665 1.00 9.98 C

ATOM 5717 ODl ASP B 363 3.371 56.193 45.943 1.00 10.17 O

ATOM 5718 OD2 ASP B 363 5.441 55.505 45.776 1.00 10.69 O

ATOM 5719 C ASP B 363 2.996 58.325 43.708 1.00 9.85 C

ATOM 5720 O ASP B 363 2.528 59.282 44.329 1.00 10.04 O

ATOM 5721 N LEU B 364 2.242 57.488 42.988 1.00 9.34 N

ATOM 5722 CA LEU B 364 0.793 57.664 42.836 1.00 9.50 C

ATOM 5723 CB LEU B 364 0.054 56.335 43.048 1.00 9.47 C

ATOM 5724 CG LEU B 364 0.258 55.626 44.401 1.00 8.85 C

ATOM 5725 CDl LEU B 364 0.300 54.206 44.359 1.00 9.22 C W2025-7029WO / AM102903-PCT

ATOM 5726 CD2 LEU B 364 0.345 56.419 45.579 1.00 8.54 C

ATOM 5727 C LEU B 364 0.401 58.313 41.496 1.00 9.36 C

ATOM 5728 O LEU B 364 0.720 58.821 41.347 1.00 9.49 O

ATOM 5729 N ASP B 365 1.325 58.292 40.535 1.00 9.16 N

ATOM 5730 CA ASP B 365 1.197 59.054 39.289 1.00 9.32 C

ATOM 5731 CB ASP B 365 2.362 58.697 38.343 1.00 9.24 C

ATOM 5732 CG ASP B 365 2.076 59.023 36.875 1.00 9.14 C

ATOM 5733 ODl ASP B 365 1.035 59.628 36.552 1.00 8.15 O

ATOM 5734 OD2 ASP B 365 2.915 58.655 36.027 1.00 9.69 O

ATOM 5735 C ASP B 365 1.206 60.558 39.623 1.00 9.76 C

ATOM 5736 O ASP B 365 1.618 60.957 40.721 1.00 9.80 O

ATOM 5737 N ASP B 366 0.732 61.392 38.698 1.00 10.10 N

ATOM 5738 CA ASP B 366 0.754 62.838 38.921 1.00 10.11 C

ATOM 5739 CB ASP B 366 0.266 63.554 38.026 1.00 10.39 C

ATOM 5740 CG ASP B 366 0.395 65.039 38.344 1.00 10.83 C

ATOM 5741 ODl ASP B 366 0.101 65.446 39.489 1.00 10.83 O

ATOM 5742 OD2 ASP B 366 0.797 65.808 37.440 1.00 11.05 O

ATOM 5743 C ASP B 366 2.180 63.359 38.703 1.00 10.48 C

ATOM 5744 O ASP B 366 2.477 64.007 37.698 1.00 9.78 O

ATOM 5745 N PHE B 367 3.061 63.052 39.653 1.00 10.54 N

ATOM 5746 CA PHE B 367 4.484 63.372 39.515 1.00 11.12 C

ATOM 5747 CB PHE B 367 5.332 62.670 40.594 1.00 11.33 C

ATOM 5748 CG PHE B 367 5.039 63.106 42.001 1.00 11.66 C

ATOM 5749 CDl PHE B 367 4.000 62.523 42.725 1.00 12.14 C

ATOM 5750 CEl PHE B 367 3.738 62.917 44.043 1.00 12.85 C

ATOM 5751 CZ PHE B 367 4.534 63.888 44.650 1.00 12.73 C

ATOM 5752 CE2 PHE B 367 5.579 64.468 43.941 1.00 11.86 C

ATOM 5753 CD2 PHE B 367 5.832 64.070 42.622 1.00 12.21 C

ATOM 5754 C PHE B 367 4.799 64.868 39.436 1.00 11.45 C

ATOM 5755 O PHE B 367 5.729 65.263 38.727 1.00 11.70 O

ATOM 5756 N THR B 368 4.023 65.694 40.139 1.00 11.67 N

ATOM 5757 CA THR B 368 4.237 67.148 40.097 1.00 12.18 C

ATOM 5758 CB THR B 368 3.535 67.897 41.264 1.00 12.08 C

ATOM 5759 OGl THR B 368 2.112 67.851 41.083 1.00 13.59 O

ATOM 5760 CG2 THR B 368 3.910 67.313 42.613 1.00 12.31 C

ATOM 5761 C THR B 368 3.734 67.765 38.792 1.00 12.20 C

ATOM 5762 O THR B 368 4.179 68.848 38.405 1.00 12.21 O

ATOM 5763 N GLY B 369 2.789 67.081 38.145 1.00 12.10 N

ATOM 5764 CA GLY B 369 2.117 67.574 36.947 1.00 12.53 C

ATOM 5765 C GLY B 369 0.969 68.537 37.222 1.00 12.76 C

ATOM 5766 O GLY B 369 0.268 68.937 36.291 1.00 12.74 O

ATOM 5767 N THR B 370 0.757 68.893 38.490 1.00 12.96 N

ATOM 5768 CA THR B 370 0.157 69.997 38.838 1.00 13.34 C

ATOM 5769 CB THR B 370 0.346 70.818 40.055 1.00 13.48 C

ATOM 5770 OGl THR B 370 0.344 70.001 41.234 1.00 15.08 O

ATOM 5771 CG2 THR B 370 1.752 71.356 39.802 1.00 14.49 C

ATOM 5772 C THR B 370 1.616 69.593 39.073 1.00 13.06 C

ATOM 5773 O THR B 370 2.508 70.454 39.102 1.00 12.77 O

ATOM 5774 N PHE B 371 1.858 68.296 39.244 1.00 12.73 N

ATOM 5775 CA PHE B 371 3.213 67.809 39.512 1.00 12.65 C

ATOM 5776 CB PHE B 371 3.185 66.567 40.411 1.00 12.71 C

ATOM 5777 CG PHE B 371 2.802 66.855 41.835 1.00 12.35 C

ATOM 5778 CDl PHE B 371 1.461 66.950 42.207 1.00 12.68 C

ATOM 5779 CEl PHE B 371 1.098 67.215 43.536 1.00 13.52 C

ATOM 5780 CZ PHE B 371 2.086 67.386 44.502 1.00 13.22 C

ATOM 5781 CE2 PHE B 371 3.430 67.291 44.141 1.00 14.01 C

ATOM 5782 CD2 PHE B 371 3.780 67.025 42.809 1.00 12.59 C

ATOM 5783 C PHE B 371 3.986 67.514 38.230 1.00 12.85 C

ATOM 5784 O PHE B 371 5.156 67.891 38.108 1.00 13.10 O

ATOM 5785 N CYS B 372 3.328 66.837 37.291 1.00 12.65 N

ATOM 5786 CA CYS B 372 3.946 66.439 36.029 1.00 12.75 C

ATOM 5787 CB CYS B 372 3.538 65.013 35.658 1.00 12.54 C

ATOM 5788 SG CYS B 372 3.724 63.836 37.030 1.00 11.49 S W2025-7029WO / AM102903-PCT

ATOM 5789 C CYS B 372 3.600 67.386 34.887 1.00 13.41 C

ATOM 5790 O CYS B 372 4.292 67.404 33.868 1.00 13.51 O

ATOM 5791 N ASN B 373 2.517 68.147 35.056 1.00 13.89 N

ATOM 5792 CA ASN B 373 2.086 69.142 34.068 1.00 14.64 C

ATOM 5793 CB ASN B 373 3.117 70.275 33.975 1.00 15.01 C

ATOM 5794 CG ASN B 373 3.448 70.875 35.327 1.00 15.73 C

ATOM 5795 ODl ASN B 373 4.560 70.711 35.832 1.00 17.93 O

ATOM 5796 ND2 ASN B 373 2.482 71.558 35.932 1.00 16.56 N

ATOM 5797 C ASN B 373 1.792 68.529 32.693 1.00 14.83 C

ATOM 5798 O ASN B 373 2.023 69.151 31.648 1.00 15.16 O

ATOM 5799 N GLN B 374 1.261 67.308 32.723 1.00 14.76 N

ATOM 5800 CA GLN B 374 0.956 66.529 31.528 1.00 15.03 C

ATOM 5801 CB GLN B 374 1.655 65.167 31.595 1.00 15.44 C

ATOM 5802 CG GLN B 374 3.170 65.189 31.588 1.00 16.29 C

ATOM 5803 CD GLN B 374 3.743 63.792 31.758 1.00 16.01 C

ATOM 5804 OEl GLN B 374 3.487 63.116 32.759 1.00 18.42 O

ATOM 5805 NE2 GLN B 374 4.510 63.351 30.778 1.00 16.76 N

ATOM 5806 C GLN B 374 0.540 66.272 31.412 1.00 14.82 C

ATOM 5807 O GLN B 374 0.959 65.330 30.734 1.00 15.02 O

ATOM 5808 N GLY B 375 1.343 67.093 32.084 1.00 14.36 N

ATOM 5809 CA GLY B 375 2.780 66.863 32.152 1.00 14.26 C

ATOM 5810 C GLY B 375 3.133 66.055 33.383 1.00 14.06 C

ATOM 5811 O GLY B 375 2.262 65.434 33.998 1.00 14.12 O

ATOM 5812 N LYS B 376 4.406 66.081 33.759 1.00 13.63 N

ATOM 5813 CA LYS B 376 4.874 65.319 34.910 1.00 13.37 C

ATOM 5814 CB LYS B 376 6.257 65.796 35.353 1.00 13.62 C

ATOM 5815 CG LYS B 376 6.236 67.169 35.998 1.00 15.98 C

ATOM 5816 CD LYS B 376 7.632 67.727 36.172 1.00 19.32 C

ATOM 5817 CE LYS B 376 7.574 69.157 36.680 1.00 22.00 C

ATOM 5818 NZ LYS B 376 8.846 69.891 36.400 1.00 24.16 N

ATOM 5819 C LYS B 376 4.890 63.827 34.608 1.00 12.67 C

ATOM 5820 O LYS B 376 5.277 63.409 33.510 1.00 12.12 O

ATOM 5821 N PHE B 377 4.456 63.037 35.592 1.00 12.12 N

ATOM 5822 CA PHE B 377 4.328 61.582 35.453 1.00 11.61 C

ATOM 5823 CB PHE B 377 5.700 60.901 35.409 1.00 11.75 C

ATOM 5824 CG PHE B 377 6.536 61.097 36.640 1.00 12.64 C

ATOM 5825 CDl PHE B 377 6.329 60.313 37.769 1.00 12.90 C

ATOM 5826 CEl PHE B 377 7.126 60.471 38.903 1.00 14.15 C

ATOM 5827 CZ PHE B 377 8.145 61.415 38.908 1.00 14.48 C

ATOM 5828 CE2 PHE B 377 8.369 62.199 37.776 1.00 14.03 C

ATOM 5829 CD2 PHE B 377 7.567 62.030 36.647 1.00 12.72 C

ATOM 5830 C PHE B 377 3.567 61.202 34.181 1.00 11.10 C

ATOM 5831 O PHE B 377 4.112 60.467 33.349 1.00 10.81 O

ATOM 5832 N PRO B 378 2.313 61.684 34.026 1.00 10.76 N

ATOM 5833 CA PRO B 378 1.622 61.498 32.745 1.00 10.66 C

ATOM 5834 CB PRO B 378 0.325 62.296 32.921 1.00 10.78 C

ATOM 5835 CG PRO B 378 0.094 62.329 34.407 1.00 10.86 C

ATOM 5836 CD PRO B 378 1.470 62.386 35.012 1.00 10.96 C

ATOM 5837 C PRO B 378 1.327 60.023 32.427 1.00 10.44 C

ATOM 5838 O PRO B 378 1.403 59.613 31.263 1.00 10.22 O

ATOM 5839 N LEU B 379 1.008 59.229 33.448 1.00 10.19 N

ATOM 5840 CA LEU B 379 0.700 57.819 33.205 1.00 10.07 C

ATOM 5841 CB LEU B 379 0.012 57.181 34.415 1.00 10.05 C

ATOM 5842 CG LEU B 379 1.396 57.706 34.711 1.00 9.89 C

ATOM 5843 CDl LEU B 379 2.085 56.838 35.759 1.00 10.07 C

ATOM 5844 CD2 LEU B 379 2.232 57.764 33.438 1.00 11.57 C

ATOM 5845 C LEU B 379 1.935 57.034 32.791 1.00 10.05 C

ATOM 5846 O LEU B 379 1.910 56.294 31.798 1.00 10.04 O

ATOM 5847 N ILE B 380 3.026 57.209 33.530 1.00 9.88 N

ATOM 5848 CA ILE B 380 4.246 56.470 33.212 1.00 10.08 C

ATOM 5849 CB ILE B 380 5.261 56.463 34.371 1.00 9.99 C

ATOM 5850 CGl ILE B 380 4.629 55.815 35.613 1.00 10.45 C

ATOM 5851 CDl ILE B 380 5.364 56.089 36.923 1.00 11.29 C W2025-7029WO / AM102903-PCT

ATOM 5852 CG2 ILE B 380 -6.506 55.676 33.978 1.00 10.26 C

ATOM 5853 C ILE B 380 -4.866 56.957 31.894 1.00 10.07 C

ATOM 5854 O ILE B 380 -5.349 56.148 31.108 1.00 10.00 O

ATOM 5855 N SER B 381 -4.812 58.267 31.657 1.00 10.64 N

ATOM 5856 CA SER B 381 -5.292 58.860 30.401 1.00 10.83 C

ATOM 5857 CB SER B 381 -5.173 60.385 30.433 1.00 10.85 C

ATOM 5858 OG SER B 381 -5.987 60.938 31.452 1.00 11.37 O

ATOM 5859 C SER B 381 -4.532 58.301 29.193 1.00 11.04 C

ATOM 5860 O SER B 381 -5.121 58.081 28.125 1.00 11.18 O

ATOM 5861 N THR B 382 -3.234 58.063 29.377 1.00 10.87 N

ATOM 5862 CA THR B 382 -2.400 57.434 28.350 1.00 11.23 C

ATOM 5863 CB THR B 382 -0.918 57.300 28.805 1.00 11.16 C

ATOM 5864 OGl THR B 382 -0.361 58.601 29.032 1.00 12.29 O

ATOM 5865 CG2 THR B 382 -0.070 56.577 27.744 1.00 11.48 C

ATOM 5866 C THR B 382 -2.968 56.062 27.977 1.00 11.35 C

ATOM 5867 O THR B 382 -3.044 55.714 26.797 1.00 11.38 O

ATOM 5868 N LEU B 383 -3.376 55.294 28.985 1.00 11.66 N

ATOM 5869 CA LEU B 383 -3.935 53.964 28.747 1.00 11.98 C

ATOM 5870 CB LEU B 383 -3.974 53.142 30.039 1.00 12.07 C

ATOM 5871 CG LEU B 383 -2.620 52.867 30.700 1.00 11.79 C

ATOM 5872 CDl LEU B 383 -2.817 52.058 31.978 1.00 11.27 C

ATOM 5873 CD2 LEU B 383 -1.649 52.160 29.745 1.00 11.94 C

ATOM 5874 C LEU B 383 -5.315 54.024 28.096 1.00 12.64 C

ATOM 5875 O LEU B 383 -5.602 53.257 27.174 1.00 12.63 O

ATOM 5876 N LYS B 384 -6.159 54.941 28.564 1.00 13.08 N

ATOM 5877 CA LYS B 384 -7.486 55.131 27.977 1.00 13.95 C

ATOM 5878 CB LYS B 384 -8.228 56.261 28.699 1.00 13.99 C

ATOM 5879 CG LYS B 384 -9.634 56.552 28.181 1.00 15.09 C

ATOM 5880 CD LYS B 384 10.291 57.649 29.011 1.00 15.85 C

ATOM 5881 CE LYS B 384 11.588 58.144 28.387 1.00 16.95 C

ATOM 5882 NZ LYS B 384 12.647 57.111 28.378 1.00 17.05 N

ATOM 5883 C LYS B 384 -7.368 55.409 26.476 1.00 14.15 C

ATOM 5884 O LYS B 384 -8.097 54.823 25.669 1.00 14.23 O

ATOM 5885 N LYS B 385 -6.429 56.280 26.112 1.00 14.67 N

ATOM 5886 CA LYS B 385 -6.188 56.625 24.713 1.00 15.50 C

ATOM 5887 CB LYS B 385 -5.221 57.814 24.603 1.00 15.58 C

ATOM 5888 CG LYS B 385 -5.801 59.125 25.081 1.00 17.60 C

ATOM 5889 CD LYS B 385 -4.771 60.248 25.050 1.00 19.52 C

ATOM 5890 CE LYS B 385 -5.309 61.509 25.723 1.00 21.74 C

ATOM 5891 NZ LYS B 385 -4.442 62.696 25.467 1.00 24.11 N

ATOM 5892 C LYS B 385 -5.654 55.432 23.921 1.00 15.39 C

ATOM 5893 O LYS B 385 -6.221 55.060 22.887 1.00 15.32 O

ATOM 5894 N ALA B 386 -4.577 54.828 24.424 1.00 15.11 N

ATOM 5895 CA ALA B 386 -3.912 53.724 23.729 1.00 15.42 C

ATOM 5896 CB ALA B 386 -2.630 53.344 24.443 1.00 15.37 C

ATOM 5897 C ALA B 386 -4.810 52.498 23.545 1.00 15.74 C

ATOM 5898 O ALA B 386 -4.714 51.804 22.535 1.00 15.88 O

ATOM 5899 N LEU B 387 -5.684 52.245 24.515 1.00 16.06 N

ATOM 5900 CA LEU B 387 -6.585 51.092 24.453 1.00 16.86 C

ATOM 5901 CB LEU B 387 -6.895 50.566 25.867 1.00 16.51 C

ATOM 5902 CG LEU B 387 -5.711 50.032 26.686 1.00 16.12 C

ATOM 5903 CDl LEU B 387 -6.158 49.638 28.097 1.00 14.84 C

ATOM 5904 CD2 LEU B 387 -5.017 48.861 25.987 1.00 15.47 C

ATOM 5905 C LEU B 387 -7.874 51.384 23.677 1.00 17.73 C

ATOM 5906 O LEU B 387 -8.801 50.567 23.663 1.00 17.52 O

ATOM 5907 N GLY B 388 -7.925 52.550 23.034 1.00 18.89 N

ATOM 5908 CA GLY B 388 -9.065 52.921 22.197 1.00 20.72 C

ATOM 5909 C GLY B 388 10.358 53.085 22.972 1.00 22.08 C

ATOM 5910 O GLY B 388 11.432 52.724 22.485 1.00 22.14 O

ATOM 5911 N LEU B 389 10.245 53.623 24.184 1.00 23.44 N

ATOM 5912 CA LEU B 389 11.395 53.856 25.049 1.00 25.01 C

ATOM 5913 CB LEU B 389 11.157 53.244 26.438 1.00 24.63 C

ATOM 5914 CG LEU B 389 11.043 51.725 26.595 1.00 24.46 C W2025-7029WO / AM102903-PCT

ATOM 5915 CDl LEU B 389 10.322 51.383 27.894 1.00 23.88 C

ATOM 5916 CD2 LEU B 389 12.410 51.045 26.539 1.00 23.88 C

ATOM 5917 C LEU B 389 11.718 55.345 25.197 1.00 26.39 C

ATOM 5918 O LEU B 389 12.620 55.702 25.946 1.00 26.53 O

ATOM 5919 N GLN B 390 10.987 56.205 24.486 1.00 28.35 N

ATOM 5920 CA GLN B 390 11.119 57.660 24.665 1.00 30.28 C

ATOM 5921 CB GLN B 390 10.035 58.421 23.891 1.00 30.42 C

ATOM 5922 CG GLN B 390 -9.692 59.788 24.491 1.00 31.80 C

ATOM 5923 CD GLN B 390 -8.803 60.646 23.593 1.00 32.83 C

ATOM 5924 OEl GLN B 390 -8.494 60.280 22.457 1.00 34.59 O

ATOM 5925 NE2 GLN B 390 -8.393 61.800 24.106 1.00 33.74 N

ATOM 5926 C GLN B 390 12.512 58.197 24.310 1.00 31.14 C

ATOM 5927 O GLN B 390 13.001 59.137 24.948 1.00 31.50 O

ATOM 5928 N SER B 391 13.146 57.594 23.304 1.00 32.20 N

ATOM 5929 CA SER B 391 14.477 58.023 22.866 1.00 33.07 C

ATOM 5930 CB SER B 391 14.600 57.930 21.337 1.00 33.13 C

ATOM 5931 OG SER B 391 14.513 56.582 20.892 1.00 34.00 O

ATOM 5932 C SER B 391 15.603 57.238 23.550 1.00 33.44 C

ATOM 5933 O SER B 391 16.755 57.280 23.105 1.00 33.66 O

ATOM 5934 N ALA B 392 15.264 56.537 24.634 1.00 33.80 N

ATOM 5935 CA ALA B 392 16.222 55.698 25.363 1.00 34.06 C

ATOM 5936 CB ALA B 392 15.516 54.877 26.430 1.00 33.98 C

ATOM 5937 C ALA B 392 17.353 56.510 25.986 1.00 34.18 C

ATOM 5938 O ALA B 392 17.160 57.660 26.392 1.00 34.38 O

ATOM 5939 N SER B 393 18.532 55.897 26.049 1.00 34.20 N

ATOM 5940 CA SER B 393 19.709 56.524 26.635 1.00 34.15 C

ATOM 5941 CB SER B 393 20.881 55.533 26.643 1.00 34.26 C

ATOM 5942 OG SER B 393 21.873 55.912 27.588 1.00 34.83 O

ATOM 5943 C SER B 393 19.418 56.986 28.055 1.00 33.97 C

ATOM 5944 O SER B 393 19.017 56.169 28.905 1.00 33.92 O

ATOM 5945 N CYS B 394 19.592 58.293 28.308 1.00 33.56 N

ATOM 5946 CA CYS B 394 19.597 58.737 29.663 1.00 33.19 C

ATOM 5947 CB CYS B 394 18.134 58.716 30.226 1.00 32.76 C

ATOM 5948 SG CYS B 394 18.023 59.305 31.948 1.00 31.12

ATOM 5949 C CYS B 394 20.689 58.051 30.497 1.00 33.49 C

ATOM 5950 O CYS B 394 21.815 58.748 30.584 1.00 33.62 O

ATOM 5951 Cl MAA C 501 1.238 51.565 61.891 1.00 10.33 C

ATOM 5952 C2 MAA C 501 1.833 51.134 60.521 1.00 10.29 C

ATOM 5953 C3 MAA C 501 2.020 52.286 59.538 1.00 10.39 C

ATOM 5954 C4 MAA C 501 0.727 53.133 59.494 1.00 11.19 C

ATOM 5955 C5 MAA C 501 0.392 53.648 60.961 1.00 11.45 C

ATOM 5956 C6 MAA C 501 -0.848 54.604 61.023 1.00 12.58 C

ATOM 5957 C7 MAA C 501 3.315 49.150 60.676 1.00 10.85 C

ATOM 5958 C8 MAA C 501 4.750 48.766 61.030 1.00 10.15 C

ATOM 5959 Nl MAA C 501 3.089 50.441 60.782 1.00 9.97 N

ATOM 5960 Ol MAA C 501 3.114 53.077 59.967 1.00 9.30 O

ATOM 5961 02 MAA C 501 0.944 54.189 58.597 1.00 12.13 O

ATOM 5962 03 MAA C 501 0.078 52.423 61.705 1.00 11.02 O

ATOM 5963 04 MAA C 501 -1.955 54.159 60.198 1.00 14.60 O

ATOM 5964 05 MAA C 501 2.486 48.332 60.346 1.00 10.23 O

ATOM 5965 C9 MAA C 501 -0.098 49.559 66.550 1.00 9.30 C

ATOM 5966 ClO MAA C 501 -0.356 51.042 66.149 1.00 9.01 C

ATOM 5967 CIl MAA C 501 -0.539 51.151 64.613 1.00 9.09 C

ATOM 5968 C12 MAA C 501 0.713 50.421 63.923 1.00 9.58 C

ATOM 5969 C13 MAA C 501 0.792 48.932 64.406 1.00 9.35 C

ATOM 5970 C14 MAA C 501 1.976 48.172 63.822 1.00 9.74 C

ATOM 5971 C15 MAA C 501 -1.547 52.328 67.861 1.00 9.31 C

ATOM 5972 C16 MAA C 501 -2.855 52.594 68.595 1.00 10.05 C

ATOM 5973 N2 MAA C 501 -1.576 51.405 66.923 1.00 9.79 N

ATOM 5974 06 MAA C 501 -1.765 50.536 64.217 1.00 10.14 O

ATOM 5975 07 MAA C 501 0.670 50.431 62.509 1.00 9.89 O

ATOM 5976 08 MAA C 501 0.986 48.974 65.818 1.00 9.32 O

ATOM 5977 09 MAA C 501 1.969 46.835 64.395 1.00 9.71 O W2025-7029WO / AM102903-PCT

ATOM 5978 OIO MAA C 501 0.520 52.952 68.138 1.00 9.88 O

ATOM 5979 C17 MAA C 501 0.613 47.311 70.770 1.00 9.23 C

ATOM 5980 C18 MAA C 501 1.371 46.509 69.692 1.00 8.56 C

ATOM 5981 C19 MAA C 501 1.492 47.473 68.512 1.00 8.46 C

ATOM 5982 C20 MAA C 501 0.203 48.310 68.598 1.00 8.99 C

ATOM 5983 C21 MAA C 501 0.250 48.635 70.089 1.00 9.20 C

ATOM 5984 C22 MAA C 501 1.090 49.250 70.653 1.00 9.99 C

ATOM 5985 C23 MAA C 501 2.715 46.776 71.492 1.00 9.77 C

ATOM 5986 C24 MAA C 501 5.082 46.116 71.887 1.00 10.30 C

ATOM 5987 C25 MAA C 501 3.761 47.314 73.657 1.00 9.56 C

ATOM 5988 N3 MAA C 501 2.651 46.243 70.267 1.00 8.78 N

ATOM 5989 N4 MAA C 501 3.833 46.823 72.257 1.00 8.59 N

ATOM 5990 Oil MAA C 501 1.527 46.678 67.326 1.00 9.69 O

ATOM 5991 012 MAA C 501 0.233 49.554 67.921 1.00 8.93 O

ATOM 5992 013 MAA C 501 2.202 48.361 70.370 1.00 11.05 O

ATOM 5993 014 MAA C 501 1.576 47.466 71.841 1.00 9.86 O

ATOM 5994 C26 MAA C 501 2.924 53.448 60.810 1.00 14.64 C

ATOM 5995 Cl MAA D 501 0.739 50.977 53.426 1.00 10.65 C

ATOM 5996 C2 MAA D 501 1.358 50.779 54.837 1.00 11.01 C

ATOM 5997 C3 MAA D 501 1.451 52.061 55.659 1.00 11.79 C

ATOM 5998 C4 MAA D 501 0.148 52.884 55.550 1.00 11.93 C

ATOM 5999 C5 MAA D 501 0.166 53.161 54.013 1.00 11.38 C

ATOM 6000 C6 MAA D 501 1.422 54.071 53.801 1.00 12.43 C

ATOM 6001 C7 MAA D 501 2.983 48.904 54.980 1.00 10.63 C

ATOM 6002 C8 MAA D 501 4.455 48.563 54.731 1.00 11.04 C

ATOM 6003 Nl MAA D 501 2.675 50.153 54.694 1.00 9.91 N

ATOM 6004 Ol MAA D 501 2.557 52.826 55.211 1.00 12.44 O

ATOM 6005 02 MAA D 501 0.339 54.067 56.292 1.00 12.19 O

ATOM 6006 03 MAA D 501 0.442 51.824 53.456 1.00 10.19 O

ATOM 6007 04 MAA D 501 2.523 53.706 54.661 1.00 13.71 O

ATOM 6008 05 MAA D 501 2.193 48.084 55.393 1.00 11.27 O

ATOM 6009 C9 MAA D 501 0.307 48.277 49.066 1.00 9.03 C

ATOM 6010 ClO MAA D 501 0.671 49.781 49.256 1.00 9.37 C

ATOM 6011 CIl MAA D 501 0.890 50.089 50.757 1.00 10.12 C

ATOM 6012 C12 MAA D 501 0.377 49.538 51.570 1.00 9.77 C

ATOM 6013 C13 MAA D 501 0.563 48.011 51.286 1.00 9.06 C

ATOM 6014 C14 MAA D 501 1.767 47.410 52.003 1.00 8.11 C

ATOM 6015 C15 MAA D 501 1.899 50.777 47.382 1.00 8.72 C

ATOM 6016 C16 MAA D 501 3.207 50.922 46.599 1.00 9.90 C

ATOM 6017 N2 MAA D 501 1.901 49.995 48.441 1.00 9.18 N

ATOM 6018 06 MAA D 501 2.112 49.503 51.226 1.00 9.80 O

ATOM 6019 07 MAA D 501 0.255 49.734 52.966 1.00 9.76 O

ATOM 6020 08 MAA D 501 0.802 47.871 49.879 1.00 8.05 O

ATOM 6021 09 MAA D 501 1.757 45.994 51.683 1.00 8.39 O

ATOM 6022 OIO MAA D 501 0.884 51.376 47.036 1.00 9.80 O

ATOM 6023 C17 MAA D 501 0.506 45.413 45.272 1.00 8.44 C

ATOM 6024 C18 MAA D 501 1.277 44.806 46.472 1.00 8.33 C

ATOM 6025 C19 MAA D 501 1.323 45.933 47.512 1.00 8.13 C

ATOM 6026 C20 MAA D 501 0.021 46.729 47.267 1.00 8.28 C

ATOM 6027 C21 MAA D 501 0.085 46.810 45.745 1.00 8.47 C

ATOM 6028 C22 MAA D 501 1.263 47.280 45.082 1.00 8.45 C

ATOM 6029 C23 MAA D 501 2.656 44.963 44.678 1.00 8.76 C

ATOM 6030 C24 MAA D 501 5.052 44.401 44.474 1.00 9.47 C

ATOM 6031 C25 MAA D 501 3.669 45.048 42.436 1.00 10.17 C

ATOM 6032 N3 MAA D 501 2.568 44.502 45.932 1.00 7.80 N

ATOM 6033 N4 MAA D 501 3.748 44.803 43.896 1.00 8.88 N

ATOM 6034 Oil MAA D 501 1.354 45.375 48.828 1.00 8.29 O

ATOM 6035 012 MAA D 501 0.026 48.075 47.711 1.00 8.16 O

ATOM 6036 013 MAA D 501 2.339 46.392 45.491 1.00 11.32 O

ATOM 6037 014 MAA D 501 1.480 45.476 44.185 1.00 9.17 O

ATOM 6038 C26 MAA D 501 3.366 52.743 54.222 1.00 14.46 C W2025-7029WO / AM102903-PCT

Accordingly, other embodiments are within the scope of the following claims.

Claims

W2025-7029WO / AM102903-PCTWHAT IS CLAIMED IS:

1. A crystallized human acidic mamalian chitinase (AMCase) polypeptide or fragment thereof.

2. A crystallized complex of a human acidic mamalian chitinase (AMCase) polypeptide or fragment thereof and an allosamidin-like ligand.

3. The crystallized human AMCase polypeptide of claim 1, wherein the AMCase comprises a chitinase catalytic domain comprising the amino acid sequence of residues about 1 to 389 of SEQ ID NO:2, or an amino acid sequence about 90% or more identical to the amino acid sequence of SEQ ID NO:2.

4. The crystallized complex of claim 2, wherein the AMCase comprises a chitinase catalytic domain comprising the amino acid sequence of residues about 1 to 389 of SEQ ID NO:2, or an amino acid sequence about 90% or more identical to the amino acid sequence of SEQ ID NO:2.

5. The crystallized human AMCase polypeptide of claim 1 or 3, wherein the AMCase comprises up to 10 conservative substitutions located at a site of the human AMCase that has about 60 to 80% access to a solvent.

6. The crystallized complex of claim 2 or 4, wherein the AMCase comprises up to 10 conservative substitutions located at a site of the human AMCase that has about 60 to 80% access to a solvent.

W2025-7029WO / AM102903-PCT

7. The crystallized complex of claim 6, wherein the allosamidin-like ligand has the structure:

(I) in which: one of Ri and R₂ is hydrogen, and the other is hydroxyl or C₁-C₄ alkoxy; one of R₃ and R₄ is hydrogen, and the other is hydroxyl or C₁-C₄ alkoxy; each of R₅ and Rio is, independently, hydrogen or C₁-C₃ alkyl; each of R₆ and Rn is, independently, Ci-C₆ alkyl; each Of R₇, R₁₂, and R₁3 is, independently, hydrogen; Ci-C₆ alkyl; C₁-C₄ haloalkyl; C₂-C₆ alkenyl; C₂-C₆ alkenyl; C₃-C₆ cycloalkyl, C₃-C₆ cycloalkenyl, heterocyclyl including from 3-6 atoms, phenyl, or heteroaryl including from 5-6 atoms, each of which is optionally substituted with one or more substituents; one of R₈ and R₉ is hydrogen, and the other is hydroxyl or C₁-C₄ alkoxy;

X is O, NH, or S;

R ₁₄ is Ci-C₆ alkyl; and

Ri₅ is hydrogen or Ci-C₆ alkyl.

8. The crystallized complex of claim 7, wherein the allosamidin-like ligand has the following substitutions: each of Ri, R₃, and R₈ can be hydrogen, and each of R₂, R₄, and R₉ can be hydroxyl; and each of R₅ and Rio can be hydrogen; and each of R₆ and Rn W2025-7029WO / AM102903-PCT

can be CH₃; and R₇ can be CH₃; andX can be O; and each of R₁₂ and Ri₃ can be hydrogen; and each of R₁₄ and R₁₅ can be CH₃.

9. The crystallized complex of claim 8, wherein the allosamidin-like ligand is methylallosamidin.

10. The crystallized human AMCase polypeptide or fragment thereof of claim 3, which is capable of diffracting X-rays to a resolution of at least about 3.7 A or less.

11. The crystallized complex of claim 4, which is capable of diffracting X-rays to a resolution of at least about 3.7 A or less.

12. The crystallized human AMCase polypeptide or fragment thereof of claim 3, which belongs to space group P2i.

13. The crystallized complex of claim 4, which belongs to space group chosen from P2i or P2i2i2i.

14. The crystallized human AMCase polypeptide or fragment thereof of claim 12, wherein the crystal has unit cell parameters of: a=69.9 A, b=92.4 A, c=111.7 A, and α= γ=90° β= 95.9°, with four human AMCase polypeptides in an asymmetric unit.

15. The crystallized complex of claim 13, wherein the crystal belongs to space group P2i and has unit cell parameters of: a=69.9 A, b=93.3 A, c=87.2 A, and α= γ=90° β= 106.92°, with three ligand-AMCase complexes in an asymmetric unit; or belongs to space group V1{1{1_\ and has unit cell parameters chosen from one or more of: a=63.69 A, b=89.29 A, c=126.69 A, and α=β=γ=90°, with two methylallosimidin-bound human AMCase polypeptides in an asymmetric unit; a=45.2 A, b=81.5 A, c=91.9 A, and α=β=γ=90°, with one complex of ligand-bound human AMCase in an asymmetric unit; or a=45.3 A, b=81.9 A, c=91.7 A, and α=β=γ=90°, with one ligand-bound human AMCase polypeptide in an asymmetric unit. W2025-7029WO / AM102903-PCT

16. The crystallized human AMCase polypeptide or fragment thereof of claim 3, which has a three-dimensional structure comprising the structural coordinates of amino acids: TYR-27, TRP-31 , PHE-58, ILE-69, GLU-70, GLY-97, GLY-98, TRP-99, ASN- 100, PHE-101, ASP-136, ASP-138, GLU-140, ALA-183, MET-210, TYR-212, ASP-213, TYR-267, ALA-295, LYS-296, GLU-297, ILE-300, MET-358, TRP-360, and LEU-364 according to Table 1, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A.

17. The crystallized complex of claim 4, which has a three-dimensional structure comprising the structural coordinates of amino acids: TYR-27, TRP-31, PHE-58, ILE- 69, GLU-70, GLY-97, GLY-98, TRP-99, ASN-100, PHE-101, ASP-136, ASP-138, GLU-140, ALA-183, MET-210, TYR-212, ASP-213, TYR-267, ALA-295, LYS-296, GLU-297, ILE-300, MET-358, TRP-360, and LEU-364 according to Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A.

18. A method of identifying an agent that binds to an acidic mammalian chitinase (AMCase), comprising: providing a three-dimensional structure of AMCase, wherein: (i) the AMCase comprises the amino acid sequence of residues about 1 to 401 of

SEQ ID NO:2, or an amino acid sequence about 90% or more identical to the amino acid sequence of SEQ ID NO: 2,

(ii) the three-dimensional structure of AMCase comprises the structural coordinates of amino acids: TYR-27, TRP-31, PHE-58, ILE-69, GLU-70, GLY-97, GLY-98, TRP-99, ASN-100, PHE-101, ASP-136, ASP-138, GLU-140, ALA-183, MET- 210, TYR-212, ASP-213, TYR-267, ALA-295, LYS-296, GLU-297, ILE-300, MET-358, TRP-360, and LEU-364 according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A; generating a three-dimensional model of the three-dimensional structure of AMCase; W2025-7029WO / AM102903-PCT

evaluating an interaction between one or more candidate agents and the three- dimensional model of AMCase, thereby identifying the agent.

5 19. A method of designing an agent that binds to an acidic mammalian chitinase

(AMCase) polypeptide or fragment thereof, comprising: providing a three-dimensional structure of AMCase, wherein: (i) the AMCase comprises the amino acid sequence of residues about 1 to 401 of SEQ ID NO: 2, or an amino acid sequence about 90% or more identical to the amino acid o sequence of SEQ ID NO:2,

(ii) the three-dimensional structure of AMCase comprises the structural coordinates of amino acids: TYR-27, TRP-31, PHE-58, ILE-69, GLU-70, GLY-97, GLY-98, TRP-99, ASN-100, PHE-101, ASP-136, ASP-138, GLU-140, ALA-183, MET- 210, TYR-212, ASP-213, TYR-267, ALA-295, LYS-296, GLU-297, ILE-300, MET-358,5 TRP-360, and LEU-364 according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A; generating a three-dimensional model of the three-dimensional structure of AMCase; and evaluating an interaction between one or more candidate agents and the three-0 dimensional model of AMCase; and altering the three-dimensional structure of AMCase, thereby designing the agent.

20. The method of claim 18 or 19, wherein the evaluation step comprises5 performing computer fitting analysis or calculating a distance between an atom of the AMCase and an atom of the candidate agent.

21. The method of claim 19, wherein the altering step comprises performing rational drug design. 0 W2025-7029WO / AM102903-PCT

22. The method of claim 18 or 19, further comprising contacting the candidate agent(s) with the AMCase and detecting a change in one or more activities of the AMCase in the presence of the candidate agent(s), relative to a predetermined level.

23. The method of claim 22, wherein the one or more activities evaluated comprise a change in binding or an enzymatic activity of the AMCase.

24. The method of claim 18 or 19, further comprising obtaining the agent.

25. The method of claim 18 or 19, further comprising providing a composition comprising the crystallized AMCase.

26. A method of designing or selecting a candidate agent that interacts with an acidic mammalian chitinase (AMCase) polypeptide or fragment thereof, comprising: (a) utilizing the X-ray three-dimensional coordinates of an AMCase ligand binding domain and (optionally) a ligand according to Table 1 or Table 2, + a root mean square deviation for alpha carbon atoms of not more than 1.5 A, to generate a three- dimensional model;

(b) identifying the amino acid residues forming the ligand binding pocket of the AMCase ligand binding domain from the three-dimensional model in step (a) in order to generate a three-dimensional representation of the ligand binding pocket of AMCase, wherein the ligand binding pocket comprises amino acids TYR-27, TRP-31, PHE-58, ILE-69, GLU-70, GLY-97, GLY-98, TRP-99, ASN-100, PHE-101, ASP-136, ASP-138, GLU-140, ALA-183, MET-210, TYR-212, ASP-213, TYR-267, ALA-295, LYS-296, GLU-297, ILE-300, MET-358, TRP-360, and LEU-364 according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A; and wherein said three-dimensional representation of the ligand binding pocket optionally has the ligand from step (a) present or absent;

(c) employing said three-dimensional representation from step (b) to design or select said candidate agent such that the interactions from step (a) are maintained between the candidate agent and the AMCase ligand binding pocket; W2025-7029WO / AM102903-PCT

(d) contacting said candidate agent with said AMCase ligand binding domain to determine the ability of said candidate agent to interact or bind said AMCase ligand binding domain; whereby the detection of the ability of said candidate agent to interact or bind said AMCase ligand binding domain, thereby identifies said candidate agent as an agent that interacts with the AMCase.

27. A method of designing or selecting a candidate agent that interacts with an acidic mammalian chitinase (AMCase) polypeptide or fragment thereof, comprising: o (a) providing a three-dimensional structure of a human AMCase ligand binding domain and (optionally) a ligand, said three-dimensional structure being obtained by subjecting a crystal comprising the AMCase ligand binding domain to X-ray diffraction and collecting data sufficient to determine the three-dimensional structure of said AMCase ligand binding domain, wherein said AMCase ligand binding domain comprises5 the amino acid sequence of SEQ ID NO: 2 or an amino acid sequence about 90% or more identical to the amino acid sequence of SEQ ID NO:2, and said crystal is characterized by space group chosen from P2i or V2_\l{λ_\,

(b) generating a three-dimensional model from the three-dimensional structure of AMCase ligand binding domain; 0 (c) identifying the amino acid residues forming the ligand binding pocket of the

AMCase ligand binding domain from the three-dimensional model in step (b) in order to generate a three-dimensional representation of the ligand binding pocket of AMCase, wherein the ligand binding pocket comprises amino acids TYR-27, TRP-31, PHE-58, ILE-69, GLU-70, GLY-97, GLY-98, TRP-99, ASN-100, PHE-101 , ASP-136, ASP-138,5 GLU-140, ALA-183, MET-210, TYR-212, ASP-213, TYR-267, ALA-295, LYS-296,

GLU-297, ILE-300, MET-358, TRP-360, and LEU-364 according to Table 1 or Table 2, +/- a root mean square deviation for alpha carbon atoms of not more than 1.5 A; and wherein said three-dimensional representation of the ligand binding pocket optionally has the ligand from step (a) present or absent; 0 (d) employing said three dimensional representation from step (c) to design or select said candidate agent; and W2025-7029WO / AM102903-PCT

(e) contacting said candidate agent with said AMCase ligand binding domain to determine the ability of said candidate agent to interact or bind said AMCase ligand binding domain; whereby the detection of the ability of said candidate agent to interact or bind said AMCase ligand binding domain thereby identifies said candidate agent as an agent that interacts with the AMCase.

28. An agent designed or identified using the method of claim 18 or 19.

29. A method for crystallizing an acidic mammalian chitinase (AMCase), comprising:

(i) providing the AMCase polypeptide or fragment thereof; (ii) (optionally) providing an allosamidin-like ligand; (iii) mixing a solution of the AMCase, and (optionally) the allosamidin- like ligand in the presence of polyethylene glycol, a salt, and a buffer; and

(iv) crystallizing the solution of step (iii), by sitting or drop vapor diffusion to form a crystalline precipitate.

30. The method of claim 29, wherein the solution of step (iii) is mixed with a crystallization buffer chosen from one or more of: 25% PEG4000, 0.1 M Sodium

Acetate, 0.2 M Ammonium Sulfate; 20% PEG 3350, 0.2 M Ammonium Formate; 24.5% PEG 3350, 0.1 M bis-tris buffer at pH 6.5; 20% PEG 3350, 0.2 Ammonium Phosphate; 20% PEG 3350, 0.2 Ammonium Fluoride; or 20% PEG 3350, 0.2 di- Ammonium citrate.