Nothing Special   »   [go: up one dir, main page]

WO2009072527A1 - 歯髄幹細胞を用いた自家又は同種移植用組成物及びその用途 - Google Patents

歯髄幹細胞を用いた自家又は同種移植用組成物及びその用途 Download PDF

Info

Publication number
WO2009072527A1
WO2009072527A1 PCT/JP2008/071975 JP2008071975W WO2009072527A1 WO 2009072527 A1 WO2009072527 A1 WO 2009072527A1 JP 2008071975 W JP2008071975 W JP 2008071975W WO 2009072527 A1 WO2009072527 A1 WO 2009072527A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
stem cell
dental pulp
allotransplantation
autotransplantation
Prior art date
Application number
PCT/JP2008/071975
Other languages
English (en)
French (fr)
Inventor
Minoru Ueda
Yoichi Yamada
Sayaka Nakamura
Kenji Ito
Yudai Nishino
Original Assignee
National University Corporation Nagoya University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation Nagoya University filed Critical National University Corporation Nagoya University
Priority to JP2009544694A priority Critical patent/JP5408578B2/ja
Priority to US12/734,911 priority patent/US20110002895A1/en
Publication of WO2009072527A1 publication Critical patent/WO2009072527A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3616—Blood, e.g. platelet-rich plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

　乳歯又は永久歯から採取される歯髄幹細胞の新規な用途を提供することを課題とする。乳歯又は永久歯の歯髄幹細胞を含むことを特徴とする自家又は同種移植用組成物が提供される。
PCT/JP2008/071975 2007-12-05 2008-12-03 歯髄幹細胞を用いた自家又は同種移植用組成物及びその用途 WO2009072527A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009544694A JP5408578B2 (ja) 2007-12-05 2008-12-03 歯髄幹細胞を用いた自家又は同種移植用組成物及びその用途
US12/734,911 US20110002895A1 (en) 2007-12-05 2008-12-03 Composition for autotransplantation or allotransplantation using dental pulp stem cell, and use of the composition

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007315195 2007-12-05
JP2007-315195 2007-12-05
JP2008-057017 2008-03-06
JP2008057017 2008-03-06

Publications (1)

Publication Number Publication Date
WO2009072527A1 true WO2009072527A1 (ja) 2009-06-11

Family

ID=40717706

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/071975 WO2009072527A1 (ja) 2007-12-05 2008-12-03 歯髄幹細胞を用いた自家又は同種移植用組成物及びその用途

Country Status (3)

Country Link
US (1) US20110002895A1 (ja)
JP (1) JP5408578B2 (ja)
WO (1) WO2009072527A1 (ja)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011009878A1 (en) * 2009-07-21 2011-01-27 Universitat Internacional De Catalunya Pluripotent stem cells obtained from dental pulp
JP2011177140A (ja) * 2010-03-03 2011-09-15 Nippon Dental Univ 幹細胞培養用の無血清培地
JP2011219432A (ja) * 2010-04-13 2011-11-04 Nagoya Univ 歯髄幹細胞を用いた神経疾患治療用組成物
JP2011229508A (ja) * 2010-04-30 2011-11-17 Terumo Corp ゲル状細胞組成物およびその製造方法
EP2476442A1 (en) * 2009-09-11 2012-07-18 National Center for Geriatrics and Gerontology Root canal filler for non-extracted tooth and non-extraction method for regenerating dental tissue
WO2012102094A1 (ja) * 2011-01-28 2012-08-02 国立大学法人 新潟大学 フィブリンゲル圧延装置
WO2012105223A1 (ja) * 2011-01-31 2012-08-09 オリンパス株式会社 免疫賦活剤
JPWO2011118795A1 (ja) * 2010-03-26 2013-07-04 国立大学法人名古屋大学 損傷部治療用組成物
WO2013146992A1 (ja) 2012-03-29 2013-10-03 日本ケミカルリサーチ株式会社 歯髄由来の多能性幹細胞の製造方法
US8920791B2 (en) 2008-03-12 2014-12-30 Japan Health Sciences Foundation Root canal filler and dental tissue regeneration method
JP2017507123A (ja) * 2014-01-27 2017-03-16 ベイジン ストマトロジー ホスピタル，キャピタル メディカル ユニバーシティ 歯原性幹細胞および遺伝的に改変された歯原性幹細胞の使用
US9597360B2 (en) 2008-04-07 2017-03-21 National Center For Geriatrics And Gerontology Method of treatment for pulpitis and/or enhancement for dentinogenesis
WO2020027163A1 (ja) 2018-07-31 2020-02-06 Ｊｃｒファーマ株式会社 歯髄由来細胞の製造方法
WO2021153719A1 (ja) 2020-01-30 2021-08-05 Ｊｃｒファーマ株式会社 歯髄由来細胞を含む医薬組成物
WO2023227972A1 (en) * 2022-05-24 2023-11-30 Iceta - Instituto De Ciências, Tecnologias E Agroambiente Da Universidade Do Porto Process for preparation and cryopreservation of dental pulp from definitive teeth and products thereof based on isolated mesenchymal stem cells

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10328103B2 (en) 2009-01-03 2019-06-25 Ray C. Wasielewski Medical treatment composition comprising mammalian dental pulp stem cells
US8470308B2 (en) * 2009-01-03 2013-06-25 Ray C. Wasielewski Enhanced medical implant comprising disrupted tooth pulp and tooth particles
US11278574B2 (en) 2013-03-15 2022-03-22 Avita International Ltd. Use of stem cells expressing mesenchymal and neuronal markers and compositions thereof to treat neurological disease
US11207352B2 (en) 2013-03-15 2021-12-28 Avita International Ltd. Compositions comprising stem cells expressing mesenchymal and neuronal markers and uses thereof to treat neurological disease
US9790468B2 (en) * 2013-03-15 2017-10-17 Avita Iinternational Ltd. Multifunctional immature dental pulp stem cells and therapeutic applications
RU2605630C1 (ru) * 2015-11-10 2016-12-27 Сергей Владимирович Сирак Способ аутотрансплантации зуба с сохранением жизнеспособности его пульпы
KR102497999B1 (ko) * 2016-03-09 2023-02-08 아비타 인터내셔널 리미티드 신경계 질환을 치료하기 위한 간엽 마커와 뉴런 마커를 발현하는 치수 줄기 세포 및 이의 조성물의 용도
CN112057205A (zh) * 2020-08-19 2020-12-11 广州医科大学附属口腔医院（广州医科大学羊城医院） 一种用于牙槽骨位点保存的3d打印牙根支架及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004504052A (ja) * 2000-07-21 2004-02-12 アメリカ合衆国 イン・ビトロおよびイン・ビボにおける成人歯髄幹細胞
JP2004201612A (ja) * 2002-12-26 2004-07-22 Minoru Ueda 未分化多能性細胞並びに、それを用いた関連組織又は歯作製方法
JP2006122518A (ja) * 2004-10-29 2006-05-18 Univ Nagoya 骨又は歯周組織形成用組成物
WO2006134921A1 (ja) * 2005-06-13 2006-12-21 National University Corporation Nagoya University 移植材料及び骨質改善剤
WO2007129453A1 (ja) * 2006-04-19 2007-11-15 National University Corporation Nagoya University 歯周軟組織再生用組成物及びその製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003231015B2 (en) * 2003-04-19 2009-10-08 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health Postnatal stem cells and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004504052A (ja) * 2000-07-21 2004-02-12 アメリカ合衆国 イン・ビトロおよびイン・ビボにおける成人歯髄幹細胞
JP2004201612A (ja) * 2002-12-26 2004-07-22 Minoru Ueda 未分化多能性細胞並びに、それを用いた関連組織又は歯作製方法
JP2006122518A (ja) * 2004-10-29 2006-05-18 Univ Nagoya 骨又は歯周組織形成用組成物
WO2006134921A1 (ja) * 2005-06-13 2006-12-21 National University Corporation Nagoya University 移植材料及び骨質改善剤
WO2007129453A1 (ja) * 2006-04-19 2007-11-15 National University Corporation Nagoya University 歯周軟組織再生用組成物及びその製造方法

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
KATSUYUKI MORITO ET AL.: "Shizui Kan Saibo o Mochiita Shishu Soshiki Saisei Yudo no Kanosei", J. ORAL BIOSCI., vol. 48, 2006, pages 167 *
KATSUYUKI MORITO ET AL.: "Shizui Saibo ni yoru Kotsuyo Soshiki Keiseino", J. ORAL BIOSCI., vol. 48, 2005, pages 156 *
KATSUYUKI MORITO ET AL.: "Shizui Saibo no Tabunkano", JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY, vol. 48, no. 6, 31 December 2005 (2005-12-31), pages 859 - 863 *
MASAHARU TAKEYASU ET AL.: "Shizui Kan Saibo no Shinkei Saibo Keifu eno Bunka Yudo", J. ORAL BIOSCI., vol. 48, 2006, pages 167 *
MIURA,M. ET AL.: "SHED: stem cells from human exfoliated deciduous teeth", PROC NATL ACAD SCI U S A, vol. 100, no. 10, 2003, pages 5807 - 5812 *
OTAKI,S. ET AL.: "Mesenchymal progenitor cells in adult human dental pulp and their ability to form bone when transplanted into immunocompromised mice", CELL BIOL INT, vol. 31, no. 10, October 2007 (2007-10-01), pages 1191 - 1197 *
PAPACCIO,G. ET AL.: "Long-term cryopreservation of dental pulp stem cells (SBP-DPSCs) and their differentiated osteoblasts: a cell source for tissue repair", J CELL PHYSIOL, vol. 208, no. 2, 2006, pages 319 - 325 *

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8920791B2 (en) 2008-03-12 2014-12-30 Japan Health Sciences Foundation Root canal filler and dental tissue regeneration method
US9597360B2 (en) 2008-04-07 2017-03-21 National Center For Geriatrics And Gerontology Method of treatment for pulpitis and/or enhancement for dentinogenesis
US9017663B2 (en) 2009-07-21 2015-04-28 Universitat Internacional De Catalunya Pluripotent stem cells obtained from dental pulp
WO2011009878A1 (en) * 2009-07-21 2011-01-27 Universitat Internacional De Catalunya Pluripotent stem cells obtained from dental pulp
EP2476442A4 (en) * 2009-09-11 2013-05-01 Nat Ct Geriatrics & Gerontology ROOT CHANNEL FILLING FOR UNCOATED TEETH AND METHOD FOR RESTORING DENTAL TISSUE WITHOUT DRAWING
US9724368B2 (en) 2009-09-11 2017-08-08 National Center For Geriatrics And Gerontology Unextracted tooth root canal filler and dental tissue regeneration method for unextracted tooth
EP2476442A1 (en) * 2009-09-11 2012-07-18 National Center for Geriatrics and Gerontology Root canal filler for non-extracted tooth and non-extraction method for regenerating dental tissue
JP2011177140A (ja) * 2010-03-03 2011-09-15 Nippon Dental Univ 幹細胞培養用の無血清培地
JPWO2011118795A1 (ja) * 2010-03-26 2013-07-04 国立大学法人名古屋大学 損傷部治療用組成物
US11135243B2 (en) 2010-03-26 2021-10-05 Shed Tech Corporation Composition for treatment of damaged part
JP2011219432A (ja) * 2010-04-13 2011-11-04 Nagoya Univ 歯髄幹細胞を用いた神経疾患治療用組成物
JP2011229508A (ja) * 2010-04-30 2011-11-17 Terumo Corp ゲル状細胞組成物およびその製造方法
JP5093546B2 (ja) * 2011-01-28 2012-12-12 国立大学法人 新潟大学 フィブリンゲル圧延装置
WO2012102094A1 (ja) * 2011-01-28 2012-08-02 国立大学法人 新潟大学 フィブリンゲル圧延装置
WO2012105223A1 (ja) * 2011-01-31 2012-08-09 オリンパス株式会社 免疫賦活剤
JP5966129B2 (ja) * 2011-01-31 2016-08-10 オリンパス株式会社 免疫賦活剤
US10041039B2 (en) 2012-03-29 2018-08-07 Jcr Pharmaceuticals Co., Ltd. Method for producing pluripotent stem cells derived from dental pulp
WO2013146992A1 (ja) 2012-03-29 2013-10-03 日本ケミカルリサーチ株式会社 歯髄由来の多能性幹細胞の製造方法
JP2017507123A (ja) * 2014-01-27 2017-03-16 ベイジン ストマトロジー ホスピタル，キャピタル メディカル ユニバーシティ 歯原性幹細胞および遺伝的に改変された歯原性幹細胞の使用
US10000738B2 (en) 2014-01-27 2018-06-19 Beijing Stomatology Hospital, Capital Medical University Usage of odontogenic stem cells and genetically modified odontogenic stem cells
WO2020027163A1 (ja) 2018-07-31 2020-02-06 Ｊｃｒファーマ株式会社 歯髄由来細胞の製造方法
KR20210041578A (ko) 2018-07-31 2021-04-15 제이씨알 파마 가부시키가이샤 치수 유래 세포의 제조 방법
WO2021153719A1 (ja) 2020-01-30 2021-08-05 Ｊｃｒファーマ株式会社 歯髄由来細胞を含む医薬組成物
WO2023227972A1 (en) * 2022-05-24 2023-11-30 Iceta - Instituto De Ciências, Tecnologias E Agroambiente Da Universidade Do Porto Process for preparation and cryopreservation of dental pulp from definitive teeth and products thereof based on isolated mesenchymal stem cells

Also Published As

Publication number Publication date
US20110002895A1 (en) 2011-01-06
JP5408578B2 (ja) 2014-02-05
JPWO2009072527A1 (ja) 2011-04-28

Similar Documents

Publication Publication Date Title
WO2009072527A1 (ja) 歯髄幹細胞を用いた自家又は同種移植用組成物及びその用途
MY157769A (en) Oral care composition to reduce or eliminate dental sensitivity
ZA201104856B (en) Oral care composition to reduce or eliminate dental sensitivity
MY152711A (en) Oral compositions containing a combination of natural extracts and related methods
WO2007095116A3 (en) Glass compositions for protecting glass and methods of making and using thereof
ZA201202685B (en) Methods of preparing mesenchymal stem cells,compositions and kit thereof
PH12012500948A1 (en) Oral compositions containing extracts of garcinia mangostana l. and related methods
WO2010009127A3 (en) Tooth whitening compositions and methods
MY164646A (en) Nicotine lozenge compositions
BR112012004135A2 (pt) implante dentário, e, kit de implante dentário
WO2010118866A8 (en) Trehalulose-containing composition, its preparation and use
WO2011100671A3 (en) Methods and compositions to improve mechanical resistance of teeth
WO2011022071A3 (en) Cardiac compositions
WO2010122332A3 (en) Xanthan gum and swellable particulate containing composition and uses thereof
EP2168527A4 (en) NEW SURFACE OF TITANIUM-BASED METAL IMPLANTS FOR INSERTION INTO BONE TISSUE
WO2009100275A3 (en) Compositions and devices
EP2046884A4 (en) ADHESIVE COMPOSITION FOR DENTAL PROSTHESIS
WO2008083130A3 (en) Amorphous and crystalline form a of carvedilol phosphate
HK1150768A1 (en) Composition and method for irrigation of a prepared dental root canal
PL1945176T3 (pl) Kompozycje klejowe do protez dentystycznych
PH12012501106A1 (en) Non-aqueous single tube dentifrice whitening compositions, methods of use and manufacture thereof
EP2056787A4 (en) DENTAL CARE COMPOSITION
EP1919688A4 (en) PROCESS FOR THE APPLICATION OF INGREDIENTS WITHIN A STRAW
MX2009003755A (es) Cristal novedoso de (s)-(+)-2-(2-clorofenil)-2-hidroxietil carbamato.
WO2010059639A3 (en) Hydroxyadamantyl inhibitors of dipeptidylpeptidase iv

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08857167

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009544694

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 12734911

Country of ref document: US

122 Ep: pct application non-entry in european phase

Ref document number: 08857167

Country of ref document: EP

Kind code of ref document: A1