Nothing Special   »   [go: up one dir, main page]

WO2009071905A3 - Use of thiolatocobalamins as regulators/selective promoters of inducible and constitutive nitric oxide synthases - Google Patents

Use of thiolatocobalamins as regulators/selective promoters of inducible and constitutive nitric oxide synthases Download PDF

Info

Publication number
WO2009071905A3
WO2009071905A3 PCT/GB2008/004023 GB2008004023W WO2009071905A3 WO 2009071905 A3 WO2009071905 A3 WO 2009071905A3 GB 2008004023 W GB2008004023 W GB 2008004023W WO 2009071905 A3 WO2009071905 A3 WO 2009071905A3
Authority
WO
WIPO (PCT)
Prior art keywords
thiolatocobalamins
inducible
regulators
nitric oxide
oxide synthases
Prior art date
Application number
PCT/GB2008/004023
Other languages
French (fr)
Other versions
WO2009071905A2 (en
Inventor
Carmen Wheatley
Mauro Perretti
Acquisto Fulvio D
Original Assignee
Queen Mary & Westfield College
Carmen Wheatley
Mauro Perretti
Acquisto Fulvio D
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Queen Mary & Westfield College, Carmen Wheatley, Mauro Perretti, Acquisto Fulvio D filed Critical Queen Mary & Westfield College
Publication of WO2009071905A2 publication Critical patent/WO2009071905A2/en
Publication of WO2009071905A3 publication Critical patent/WO2009071905A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides methods of treatment and uses of thiolatocobalamin compounds for diseases characterised by NOS depression, malfunction, or dysregulation, for example inflammation, the inflammatory phase of the immune response, SIRS/sepsis/septic, traumatic, anaphylactic shock, a bacterial, viral or parasitidal disease, cancer, spinal injury or cardiovascular disease.
PCT/GB2008/004023 2007-12-07 2008-12-05 Use of thiolatocobalamins as regulators/selective promoters of inducible and constitutive nitric oxide synthases WO2009071905A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0723972.6 2007-12-07
GBGB0723972.6A GB0723972D0 (en) 2007-12-07 2007-12-07 Use of vitamin B12

Publications (2)

Publication Number Publication Date
WO2009071905A2 WO2009071905A2 (en) 2009-06-11
WO2009071905A3 true WO2009071905A3 (en) 2009-08-20

Family

ID=39016338

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/004023 WO2009071905A2 (en) 2007-12-07 2008-12-05 Use of thiolatocobalamins as regulators/selective promoters of inducible and constitutive nitric oxide synthases

Country Status (2)

Country Link
GB (1) GB0723972D0 (en)
WO (1) WO2009071905A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI798320B (en) * 2017-12-21 2023-04-11 國立大學法人大阪大學 Therapeutic agent for nervous system disease

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002087593A1 (en) * 2001-04-25 2002-11-07 Cobalz Limited A method for treating or preventing a functional vitamin b12 deficiency in an individual and to medical compositions for use in said method
WO2002100429A1 (en) * 2001-06-11 2002-12-19 Transition Therapeutics Inc. Combination therapies using vitamin b12 and interferon for treatment of viral, proliferative and inflammatory diseases
US20030017135A1 (en) * 2001-07-17 2003-01-23 Cruz Tony F. Pharmaceutical compositions comprising vitamin B12 and interferon for treating multiple sclerosis
WO2007070983A1 (en) * 2005-12-22 2007-06-28 Apollo Life Sciences Limited Transdermal delivery of pharmaceutical agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002087593A1 (en) * 2001-04-25 2002-11-07 Cobalz Limited A method for treating or preventing a functional vitamin b12 deficiency in an individual and to medical compositions for use in said method
WO2002100429A1 (en) * 2001-06-11 2002-12-19 Transition Therapeutics Inc. Combination therapies using vitamin b12 and interferon for treatment of viral, proliferative and inflammatory diseases
US20030017135A1 (en) * 2001-07-17 2003-01-23 Cruz Tony F. Pharmaceutical compositions comprising vitamin B12 and interferon for treating multiple sclerosis
WO2007070983A1 (en) * 2005-12-22 2007-06-28 Apollo Life Sciences Limited Transdermal delivery of pharmaceutical agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; February 2007 (2007-02-01), WHEATLEY CARMEN: "The return of the Scarlet Pimpernel: cobalamin in inflammation II - cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS", XP002515780, Database accession no. PREV200800207481 *
JOURNAL OF NUTRITIONAL & ENVIRONMENTAL MEDICINE (ABINGDON), vol. 16, no. 1-4, February 2007 (2007-02-01), pages 181 - 211, ISSN: 1359-0847 *
WHEATLEY CARMEN: "Cobalamin in inflammation III - glutathionylcobalamin and methylcobalamin/adenosylcobalamin coenzymes: the sword in the stone? How cobalamin may directly regulate the nitric oxide synthases", JOURNAL OF NUTRITIONAL & ENVIRONMENTAL MEDICINE (ABINGDON), vol. 16, no. 1-4, February 2007 (2007-02-01), pages 212 - 226, XP009112273, ISSN: 1359-0847 *
WHEATLEY ET AL: "A scarlet pimpernel for the resolution of inflammation? The role of supra-therapeutic doses of cobalamin, in the treatment of systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic or traumatic shock", MEDICAL HYPOTHESES, EDEN PRESS, PENRITH, US, vol. 67, no. 1, 1 January 2006 (2006-01-01), pages 124 - 142, XP005397024, ISSN: 0306-9877 *

Also Published As

Publication number Publication date
GB0723972D0 (en) 2008-01-23
WO2009071905A2 (en) 2009-06-11

Similar Documents

Publication Publication Date Title
PH12015500248A1 (en) Humanized anti-cxcr5 antibodies, derivatives thereof and their uses
WO2010032059A3 (en) Antibodies directed to cd105 and uses thereof
WO2007075869A3 (en) Bicyclic heteroaryl compounds
MY177564A (en) Anti-nr10 antibody and use thereof
WO2009026117A3 (en) Novel compounds
WO2009052081A3 (en) Antibodies that bind il-4 and/or il-13 and their uses
WO2009070243A3 (en) Wise binding antibodies and epitopes
WO2009128963A3 (en) Cross-neutralizing human monoclonal antibodies to sars-cov and methods of use thereof
WO2007084868A3 (en) Treatment of disorders by activation of the unfolded protein response
WO2008070344A3 (en) Compositions and methods for binding sphingosine-1-phosphate
WO2009013543A3 (en) Targeted binging agents directed to kdr and uses thereof - 035
WO2008097461A3 (en) Hepcidin and hepcidin antibodies
WO2007021937A3 (en) Unsaturated heterocyclic derivatives
WO2008019061A3 (en) Anti-il-6 monoclonal antibodies and uses thereof
WO2007133560A3 (en) Acetylenic heteroaryl compounds
WO2006099875A8 (en) Antibodies against cd38 for treatment of multiple myeloma
WO2008097439A3 (en) Anti-autoimmune antibodies for treatment of pemphigus
WO2008060705A3 (en) Anti-dll4 antibodies and methods using same
WO2009071696A3 (en) Humanized antibody molecules specific for il-31
WO2008029096A3 (en) P53 activating benzoyl urea and benzoyl thiourea compounds
WO2007130697A8 (en) Anti-ephb4 antibodies and methods using same
WO2007127292A3 (en) Tigeycline crystalline forms and processes for preparation thereof
WO2007133562A3 (en) Monocyclic heteroaryl compounds
WO2007106915A8 (en) Antibodies to egfl7 and methods for their use
WO2008079352A3 (en) Antibodies to cd200r

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08856448

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08856448

Country of ref document: EP

Kind code of ref document: A2