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WO2008133208A1 - ペプチド免疫応答増強方法 - Google Patents

ペプチド免疫応答増強方法 Download PDF

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Publication number
WO2008133208A1
WO2008133208A1 PCT/JP2008/057612 JP2008057612W WO2008133208A1 WO 2008133208 A1 WO2008133208 A1 WO 2008133208A1 JP 2008057612 W JP2008057612 W JP 2008057612W WO 2008133208 A1 WO2008133208 A1 WO 2008133208A1
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WO
WIPO (PCT)
Prior art keywords
peptide
immune response
enhancing
amyloid
enhancing immune
Prior art date
Application number
PCT/JP2008/057612
Other languages
English (en)
French (fr)
Inventor
Junichi Matsuda
Kazuyoshi Kaminaka
Chikateru Nozaki
Original Assignee
Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Juridical Foundation The Chemo-Sero-Therapeutic Research Institute filed Critical Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
Priority to JP2009511859A priority Critical patent/JP5349297B2/ja
Priority to US12/596,741 priority patent/US8106015B2/en
Priority to EP08751882.5A priority patent/EP2149584B1/en
Priority to ES08751882.5T priority patent/ES2655868T3/es
Publication of WO2008133208A1 publication Critical patent/WO2008133208A1/ja
Priority to US13/220,452 priority patent/US8623374B2/en
Priority to US14/018,495 priority patent/US8940306B2/en
Priority to US14/313,007 priority patent/US20140343248A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　安全かつ効果的な免疫応答増強方法および当該免疫応答増強が可能なアミロイドβペプチドを用いたアルツハイマー病の予防・治療薬の提供を課題とする。 　システインを付加または挿入したアミロイドβペプチドまたはその一部、および当該ペプチドを用いた免疫応答増強方法、または当該ペプチドにアジュバントを添加する免疫応答増強方法。当該免疫応答増強アミロイドβペプチドまたはその一部を用いた、アルツハイマー病の予防・治療薬。同様の効果が期待される、システインが付加または挿入された当該免疫応答増強アミロイドβペプチドまたはその一部をコードする遺伝子を含むＤＮＡワクチン。
PCT/JP2008/057612 2007-04-20 2008-04-18 ペプチド免疫応答増強方法 WO2008133208A1 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2009511859A JP5349297B2 (ja) 2007-04-20 2008-04-18 ペプチド免疫応答増強方法
US12/596,741 US8106015B2 (en) 2007-04-20 2008-04-18 Method for enhancing immune response with peptide
EP08751882.5A EP2149584B1 (en) 2007-04-20 2008-04-18 Method for enhancing immune response with peptide
ES08751882.5T ES2655868T3 (es) 2007-04-20 2008-04-18 Método para aumentar la respuesta inmunitaria con un péptido
US13/220,452 US8623374B2 (en) 2007-04-20 2011-08-29 Method for enhancing immune response with peptide
US14/018,495 US8940306B2 (en) 2007-04-20 2013-09-05 Method for enhancing immune response with peptide
US14/313,007 US20140343248A1 (en) 2007-04-20 2014-06-24 Method for enhancing immune response with peptide

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-112060 2007-04-20
JP2007112060 2007-04-20
JP2007-279083 2007-10-26
JP2007279083 2007-10-26

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/596,741 A-371-Of-International US8106015B2 (en) 2007-04-20 2008-04-18 Method for enhancing immune response with peptide
US13/220,452 Continuation US8623374B2 (en) 2007-04-20 2011-08-29 Method for enhancing immune response with peptide

Publications (1)

Publication Number Publication Date
WO2008133208A1 true WO2008133208A1 (ja) 2008-11-06

Family

ID=39925662

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/057612 WO2008133208A1 (ja) 2007-04-20 2008-04-18 ペプチド免疫応答増強方法

Country Status (6)

Country Link
US (4) US8106015B2 (ja)
EP (1) EP2149584B1 (ja)
JP (1) JP5349297B2 (ja)
ES (1) ES2655868T3 (ja)
TR (1) TR201802286T4 (ja)
WO (1) WO2008133208A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2348042A1 (en) * 2008-10-16 2011-07-27 The Chemo-Sero-Therapeutic Research Institute Modified amyloid beta peptide
EP2471915A1 (en) * 2009-08-28 2012-07-04 The Chemo-Sero-Therapeutic Research Institute Modified peptide vaccine derived from influenza m2
WO2012124631A1 (ja) 2011-03-11 2012-09-20 一般財団法人化学及血清療法研究所 シトルリンを含有するアジュバント組成物
JP2012528111A (ja) * 2009-05-26 2012-11-12 アラクロン、バイオテク、ソシエダッド、リミターダ アルブミン−アミロイドペプチドコンジュゲートおよびその使用
JP2014040396A (ja) * 2012-08-23 2014-03-06 Chemo-Sero-Therapeutic Research Institute 脂質異常症治療薬を含有するアジュバント組成物

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2149584B1 (en) * 2007-04-20 2017-12-13 The Chemo-Sero-Therapeutic Research Institute Method for enhancing immune response with peptide
WO2013041962A1 (en) 2011-09-19 2013-03-28 Axon Neuroscience Se Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease
US9610326B2 (en) * 2011-10-17 2017-04-04 The Board Of Trustees Of The Leland Stanford Junior University Amyloid beta peptides as therapy for multiple sclerosis
US10662226B2 (en) * 2016-10-28 2020-05-26 The Regents of the University of Caiifomia Synthetic beta-amyloid peptides capable of forming stable antigenic oligomers

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004500354A (ja) * 1999-11-29 2004-01-08 ニューロケム　インコーポレーティッド 全ｄ体ペプチドを含む、アルツハイマー病およびアミロイド関連疾患の予防および処置のためのワクチン
JP2004538332A (ja) * 2001-08-20 2004-12-24 ファーメクサ エイ／エス β−アミロイドアナログ−Ｔ細胞エピトープワクチン
JP2005506311A (ja) * 2001-05-25 2005-03-03 ユナイテッド・バイオメディカル・インコーポレーテッド アルツハイマー病の予防用及び処置用免疫原性ペプチド組成物
WO2005072777A2 (en) * 2004-01-28 2005-08-11 Curix Aps Conjugates of amyloid proteins as vaccines for amyloid-related diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5589154A (en) * 1994-11-22 1996-12-31 Rutgers, The State University Of New Jersey Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease
US6787523B1 (en) * 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
DE19916417A1 (de) * 1999-04-01 2000-10-19 Schering Ag Amyloidspezifisches Aptamer
UA81216C2 (en) * 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
WO2003040183A2 (en) * 2001-11-09 2003-05-15 The Genetics Company, Inc Compounds for the diagnosis/prevention/treatment of alzheimer's disease
EP2479184A3 (en) * 2003-12-17 2013-09-04 Janssen Alzheimer Immunotherapy Beta immunogenic peptide carrier conjugates and methods of producing the same
EP2149584B1 (en) * 2007-04-20 2017-12-13 The Chemo-Sero-Therapeutic Research Institute Method for enhancing immune response with peptide
WO2010044464A1 (ja) 2008-10-16 2010-04-22 財団法人化学及血清療法研究所 改変アミロイドβペプチド
CN102612559B (zh) 2009-08-28 2015-06-10 一般财团法人化学及血清疗法研究所 源自流感m2的修饰的肽疫苗

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004500354A (ja) * 1999-11-29 2004-01-08 ニューロケム　インコーポレーティッド 全ｄ体ペプチドを含む、アルツハイマー病およびアミロイド関連疾患の予防および処置のためのワクチン
JP2005506311A (ja) * 2001-05-25 2005-03-03 ユナイテッド・バイオメディカル・インコーポレーテッド アルツハイマー病の予防用及び処置用免疫原性ペプチド組成物
JP2004538332A (ja) * 2001-08-20 2004-12-24 ファーメクサ エイ／エス β−アミロイドアナログ−Ｔ細胞エピトープワクチン
WO2005072777A2 (en) * 2004-01-28 2005-08-11 Curix Aps Conjugates of amyloid proteins as vaccines for amyloid-related diseases

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
FOX NC; BLACK RS; GILMAN S; ROSSOR MN; GRIFFITH SG; JENKINS L ET AL.: "Effects of A beta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease", NEUROLOGY, vol. 64, 2005, pages 1563 - 1572
FRENKEL D. ET AL.: "Immunization against Alzheimer's beta-amyloid plaques via EFRH phase administration", PROC. NATL. ACAD. SCI. USA, vol. 97, no. 21, 2000, pages 11455 - 11459, XP002180061 *
HEAD E. ET AL.: "Immunization with fibrillar Abeta1-42 in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta", VACCINE, vol. 24, 2006, pages 2824 - 2834, XP005337648 *
MORGAN D. ET AL.: "Abeta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease", NATURE, vol. 408, 2000, pages 982 - 985, XP002266055 *
NICOLL JA; WILKINSON D; HOLMES C; STEART P; MARKHAM H; WELLER RO.: "Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report", NAT MED, vol. 9, 2003, pages 448 - 452, XP055019491, DOI: doi:10.1038/nm840
NIKOLIC W.V. ET AL.: "Transcutaneous betaamyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage", PROC. NATL. ACAD. SCI. USA, vol. 104, no. 7, 13 February 2007 (2007-02-13), pages 2507 - 2512, XP008125300 *
SCHENK D; BARBOUR R; DUNN W; GORDON G; GRAJEDA H; GUIDO T ET AL.: "Immunization with amyloid-beta attenuates Alzheimer disease -disease-like pathology in the PDAPP mouse", NATURE, vol. 400, 1999, pages 173 - 177
WETTSTEIN P.J. ET AL.: "Cystein-tailed class I-binding peptides bind to CpG adjuvant and enhance primary CTL responses", J. IMMUNOL., vol. 175, 2005, pages 3681 - 3689, XP002455097 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2348042A4 (en) * 2008-10-16 2012-03-28 Chemo Sero Therapeut Res Inst AMYLOID PEPTIDE BETA MODIFIED
US8512709B2 (en) 2008-10-16 2013-08-20 The Chemo-Sero-Therapeutic Research Institue Modified amyloid β peptide
EP2348042A1 (en) * 2008-10-16 2011-07-27 The Chemo-Sero-Therapeutic Research Institute Modified amyloid beta peptide
CN102245629B (zh) * 2008-10-16 2014-06-25 一般财团法人化学及血清疗法研究所 修饰的淀粉状蛋白β肽
US9163062B2 (en) 2009-05-26 2015-10-20 Aracion Biotech S.L. Albumin-amyloid peptide conjugates and uses thereof
JP2012528111A (ja) * 2009-05-26 2012-11-12 アラクロン、バイオテク、ソシエダッド、リミターダ アルブミン−アミロイドペプチドコンジュゲートおよびその使用
JP2015096512A (ja) * 2009-05-26 2015-05-21 アラクロン、バイオテク、ソシエダッド、リミターダＡｒａｃｌｏｎ Ｂｉｏｔｅｃｈ Ｓ．Ｌ． アルブミン−アミロイドペプチドコンジュゲートおよびその使用
US8883165B2 (en) 2009-08-28 2014-11-11 The Chemo-Sero-Therapeutic Research Institute Modified peptide vaccine derived from influenza M2
EP2471915A1 (en) * 2009-08-28 2012-07-04 The Chemo-Sero-Therapeutic Research Institute Modified peptide vaccine derived from influenza m2
CN102612559A (zh) * 2009-08-28 2012-07-25 一般财团法人化学及血清疗法研究所 源自流感m2的修饰的肽疫苗
EP2471915A4 (en) * 2009-08-28 2013-05-01 Chemo Sero Therapeut Res Inst MODIFIED PEPTIDE VACCINE FROM A GRIPPAL M2
JP5730204B2 (ja) * 2009-08-28 2015-06-03 一般財団法人化学及血清療法研究所 インフルエンザｍ２由来の改変ペプチドワクチン
EP2684572A1 (en) * 2011-03-11 2014-01-15 The Chemo-Sero-Therapeutic Research Institute Adjuvant composition containing citrulline
EP2684572A4 (en) * 2011-03-11 2014-09-10 Chemo Sero Therapeut Res Inst CITRALLINE-CONTAINING AUXILIARY COMPOSITION
CN103561764A (zh) * 2011-03-11 2014-02-05 一般财团法人化学及血清疗法研究所 含有瓜氨酸的佐剂组合物
WO2012124631A1 (ja) 2011-03-11 2012-09-20 一般財団法人化学及血清療法研究所 シトルリンを含有するアジュバント組成物
US9381242B2 (en) 2011-03-11 2016-07-05 The Chemo—Sero—Therapeutic Research Institute Adjuvant composition containing citrulline
US10556005B2 (en) 2011-03-11 2020-02-11 The Chemo-Sero-Therapeutic Research Institute Adjuvant composition containing citrulline
JP2014040396A (ja) * 2012-08-23 2014-03-06 Chemo-Sero-Therapeutic Research Institute 脂質異常症治療薬を含有するアジュバント組成物

Also Published As

Publication number Publication date
US20140044743A1 (en) 2014-02-13
US20140343248A1 (en) 2014-11-20
EP2149584B1 (en) 2017-12-13
US8623374B2 (en) 2014-01-07
TR201802286T4 (tr) 2018-03-21
JPWO2008133208A1 (ja) 2010-07-22
US20120107334A1 (en) 2012-05-03
EP2149584A1 (en) 2010-02-03
JP5349297B2 (ja) 2013-11-20
US8106015B2 (en) 2012-01-31
US8940306B2 (en) 2015-01-27
ES2655868T3 (es) 2018-02-22
EP2149584A4 (en) 2010-07-07
US20100291122A1 (en) 2010-11-18

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