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WO2008126151A1 - 質量分析データ解析方法及び装置 - Google Patents

質量分析データ解析方法及び装置 Download PDF

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Publication number
WO2008126151A1
WO2008126151A1 PCT/JP2007/000366 JP2007000366W WO2008126151A1 WO 2008126151 A1 WO2008126151 A1 WO 2008126151A1 JP 2007000366 W JP2007000366 W JP 2007000366W WO 2008126151 A1 WO2008126151 A1 WO 2008126151A1
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WO
WIPO (PCT)
Prior art keywords
mass
peaks
mass spectrum
window
aggregating
Prior art date
Application number
PCT/JP2007/000366
Other languages
English (en)
French (fr)
Inventor
Shigeki Kajihara
Original Assignee
Shimadzu Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shimadzu Corporation filed Critical Shimadzu Corporation
Priority to JP2009508705A priority Critical patent/JP4952788B2/ja
Priority to US12/594,480 priority patent/US8119982B2/en
Priority to PCT/JP2007/000366 priority patent/WO2008126151A1/ja
Publication of WO2008126151A1 publication Critical patent/WO2008126151A1/ja

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F2218/00—Aspects of pattern recognition specially adapted for signal processing
    • G06F2218/08—Feature extraction
    • G06F2218/10—Feature extraction by analysing the shape of a waveform, e.g. extracting parameters relating to peaks

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

　試料上の二次元領域を細かく区分した各微小領域（ピクセル）に対して得られる質量スペクトルデータを解析処理しタンパク質を同定するに際し、まず各ピクセルの質量スペクトルに現れるピークを含むように質量ウインドウを設定し（Ｓ１０）、各質量ウインドウ内に入るピークのイオン強度の積算値を計算する（Ｓ１１）。そして、質量ウインドウ毎に各ピクセルの強度積算値を集めてマッピング画像を作成し（Ｓ１２）、マッピング画像の類似性を判断して質量ウインドウをグループ分けする（Ｓ１３、Ｓ１４）。同一グループに入る質量ウインドウ内のピークは同一種類の物質に由来するとみなし、それらピークを集めて質量スペクトルを作成し（Ｓ１５）、該スペクトルに基づいてＰＭＦ法などによりタンパク質を同定する（Ｓ１６、Ｓ１７）。これにより、複数種類のタンパク質が混在している場合でも、同定精度を高めることができる。　
PCT/JP2007/000366 2007-04-04 2007-04-04 質量分析データ解析方法及び装置 WO2008126151A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009508705A JP4952788B2 (ja) 2007-04-04 2007-04-04 質量分析データ解析方法及び装置
US12/594,480 US8119982B2 (en) 2007-04-04 2007-04-04 Method and system for mass spectrometry data analysis
PCT/JP2007/000366 WO2008126151A1 (ja) 2007-04-04 2007-04-04 質量分析データ解析方法及び装置

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/000366 WO2008126151A1 (ja) 2007-04-04 2007-04-04 質量分析データ解析方法及び装置

Publications (1)

Publication Number Publication Date
WO2008126151A1 true WO2008126151A1 (ja) 2008-10-23

Family

ID=39863336

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/000366 WO2008126151A1 (ja) 2007-04-04 2007-04-04 質量分析データ解析方法及び装置

Country Status (3)

Country Link
US (1) US8119982B2 (ja)
JP (1) JP4952788B2 (ja)
WO (1) WO2008126151A1 (ja)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012517588A (ja) * 2009-02-06 2012-08-02 マイクロマス・ユー・ケイ・リミテツド 質量分析方法
JP2012247198A (ja) * 2011-05-25 2012-12-13 Shimadzu Corp 質量分析データ解析方法及び解析装置
JP2013178233A (ja) * 2012-01-30 2013-09-09 Canon Inc 生体組織画像のノイズ低減処理方法及び装置
JP2014508946A (ja) * 2011-03-21 2014-04-10 イマビオテク サンプル中のターゲット分子を検出及び定量化するための方法
JP2017173103A (ja) * 2016-03-23 2017-09-28 日本電子株式会社 質量分析装置
WO2017195271A1 (ja) * 2016-05-10 2017-11-16 株式会社島津製作所 イメージング質量分析装置
WO2018037569A1 (ja) * 2016-08-26 2018-03-01 株式会社島津製作所 イメージング質量分析データ処理装置及び方法
WO2018037491A1 (ja) * 2016-08-24 2018-03-01 株式会社島津製作所 イメージング質量分析装置
CN113740408A (zh) * 2020-05-28 2021-12-03 塞莫费雪科学（不来梅）有限公司 用于确定ms扫描数据中的干扰、过滤离子并对样品进行质谱分析的方法和装置
CN114761795A (zh) * 2019-12-17 2022-07-15 豪夫迈·罗氏有限公司 用于多跃迁监测的方法和装置

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007024857B4 (de) * 2007-05-29 2017-11-02 Bruker Daltonik Gmbh Bildgebende Massenspektrometrie für kleine Moleküle in flächigen Proben
US8324569B2 (en) * 2008-07-03 2012-12-04 Shimadzu Corporation Mass spectrometer
JP5359924B2 (ja) * 2010-02-18 2013-12-04 株式会社島津製作所 質量分析装置
JP6044385B2 (ja) * 2013-02-26 2016-12-14 株式会社島津製作所 タンデム型質量分析装置
CN106233421A (zh) * 2014-04-02 2016-12-14 斯坦福大学托管董事会 用于通过质谱仪进行亚微米元素图像分析的设备和方法
US11408866B2 (en) * 2016-03-14 2022-08-09 Shimadzu Corporation Mass spectrometric data analyzer and mass spectrometric data analyzing program
WO2019150554A1 (ja) * 2018-02-02 2019-08-08 株式会社島津製作所 イメージング質量分析用データ処理装置
JP6973638B2 (ja) * 2018-05-30 2021-12-01 株式会社島津製作所 イメージングデータ処理装置

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JP2006010658A (ja) * 2003-07-02 2006-01-12 Canon Inc 情報取得方法、情報取得装置及び検出方法

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US5808300A (en) * 1996-05-10 1998-09-15 Board Of Regents, The University Of Texas System Method and apparatus for imaging biological samples with MALDI MS
JP3658397B2 (ja) * 2002-06-28 2005-06-08 キヤノン株式会社 飛行時間型二次イオン質量分析法による素子の情報取得方法、および、情報取得装置
DE602004020351D1 (de) 2003-07-02 2009-05-14 Canon Kk Verfahren zur informationsbeschaffung und verfahren zur krankheitsdiagnose mittels sekundärionenmassenspektrometrie
JP2006284509A (ja) 2005-04-04 2006-10-19 Shimadzu Corp 質量分析システム
JP4614000B2 (ja) * 2006-04-07 2011-01-19 株式会社島津製作所 質量分析装置
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BÖRNER K. ET AL.: "Molecular imaging of lipids in cells and tissues", INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 260, no. 2-3, 1 February 2007 (2007-02-01), pages 128 - 136, XP005822709 *
GARRET T.J. ET AL.: "Imaging of small molecules in tissue sections with a new intermediate-pressure MALDI linear ion trap mass spectrometer", INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 260, no. 2-3, 1 February 2007 (2007-02-01), pages 166 - 176, XP005822713 *
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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012517588A (ja) * 2009-02-06 2012-08-02 マイクロマス・ユー・ケイ・リミテツド 質量分析方法
JP2014508946A (ja) * 2011-03-21 2014-04-10 イマビオテク サンプル中のターゲット分子を検出及び定量化するための方法
JP2012247198A (ja) * 2011-05-25 2012-12-13 Shimadzu Corp 質量分析データ解析方法及び解析装置
US9075782B2 (en) 2011-05-25 2015-07-07 Shimadzu Corporation Mass spectrometry data analysis method and analysis device
JP2013178233A (ja) * 2012-01-30 2013-09-09 Canon Inc 生体組織画像のノイズ低減処理方法及び装置
JP2017173103A (ja) * 2016-03-23 2017-09-28 日本電子株式会社 質量分析装置
WO2017195271A1 (ja) * 2016-05-10 2017-11-16 株式会社島津製作所 イメージング質量分析装置
JPWO2017195271A1 (ja) * 2016-05-10 2018-11-08 株式会社島津製作所 イメージング質量分析装置
WO2018037491A1 (ja) * 2016-08-24 2018-03-01 株式会社島津製作所 イメージング質量分析装置
JPWO2018037491A1 (ja) * 2016-08-24 2019-01-10 株式会社島津製作所 イメージング質量分析装置
WO2018037569A1 (ja) * 2016-08-26 2018-03-01 株式会社島津製作所 イメージング質量分析データ処理装置及び方法
JPWO2018037569A1 (ja) * 2016-08-26 2019-01-10 株式会社島津製作所 イメージング質量分析データ処理装置及び方法
CN114761795A (zh) * 2019-12-17 2022-07-15 豪夫迈·罗氏有限公司 用于多跃迁监测的方法和装置
CN113740408A (zh) * 2020-05-28 2021-12-03 塞莫费雪科学（不来梅）有限公司 用于确定ms扫描数据中的干扰、过滤离子并对样品进行质谱分析的方法和装置

Also Published As

Publication number Publication date
US8119982B2 (en) 2012-02-21
JPWO2008126151A1 (ja) 2010-07-15
JP4952788B2 (ja) 2012-06-13
US20100116981A1 (en) 2010-05-13

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