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WO2008103849A3 - Methods and compounds for lymphoma cell detection and isolation - Google Patents

Methods and compounds for lymphoma cell detection and isolation Download PDF

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Publication number
WO2008103849A3
WO2008103849A3 PCT/US2008/054613 US2008054613W WO2008103849A3 WO 2008103849 A3 WO2008103849 A3 WO 2008103849A3 US 2008054613 W US2008054613 W US 2008054613W WO 2008103849 A3 WO2008103849 A3 WO 2008103849A3
Authority
WO
WIPO (PCT)
Prior art keywords
ror
isolation
compounds
methods
sera
Prior art date
Application number
PCT/US2008/054613
Other languages
French (fr)
Other versions
WO2008103849A2 (en
WO2008103849A4 (en
Inventor
Thomas J Kipps
Tetsuya Fukuda
Tomoyuki Endo
Original Assignee
Univ California
Thomas J Kipps
Tetsuya Fukuda
Tomoyuki Endo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/709,917 external-priority patent/US20070207510A1/en
Application filed by Univ California, Thomas J Kipps, Tetsuya Fukuda, Tomoyuki Endo filed Critical Univ California
Publication of WO2008103849A2 publication Critical patent/WO2008103849A2/en
Publication of WO2008103849A3 publication Critical patent/WO2008103849A3/en
Publication of WO2008103849A4 publication Critical patent/WO2008103849A4/en
Priority to US12/545,731 priority Critical patent/US8212009B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00118—Cancer antigens from embryonic or fetal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Compositions comprising a purified and/or isolated antibody, humanized antibodies, precipitates and anti-sera that specifically bind to or are otherwise directed against ROR-1 protein. The compositions may be used for detecting ROR-1 in a sample from a subject that is suspected or known to contain cancer cells. The ROR-1 antibodies are especially useful in identifying and treating lymphomas and ademocarcinomas. Vaccines and related methods for protecting a subject against diseases that involve expression of ROR-1 are also provided, as are human anti-sera effective in abrogating interactions between Wnt5a protein and ROR-1 that contribute to the survival of certain cancer cells, such as CLL cells.
PCT/US2008/054613 2005-10-28 2008-02-21 Methods and compounds for lymphoma cell detection and isolation WO2008103849A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/545,731 US8212009B2 (en) 2005-10-28 2009-08-21 Methods and compounds for lymphoma cell detection and isolation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/709,917 US20070207510A1 (en) 2005-10-28 2007-02-21 Methods and compounds for lymphoma cell detection and isolation
US11/709,917 2007-02-21
US97181807P 2007-09-12 2007-09-12
US60/971,818 2007-09-12

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2006/042689 Continuation-In-Part WO2007051077A2 (en) 2005-10-28 2006-10-30 Methods and compounds for lymphoma cell detection and isolation
US11/709,917 Continuation US20070207510A1 (en) 2005-10-28 2007-02-21 Methods and compounds for lymphoma cell detection and isolation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/545,731 Continuation-In-Part US8212009B2 (en) 2005-10-28 2009-08-21 Methods and compounds for lymphoma cell detection and isolation

Publications (3)

Publication Number Publication Date
WO2008103849A2 WO2008103849A2 (en) 2008-08-28
WO2008103849A3 true WO2008103849A3 (en) 2008-10-23
WO2008103849A4 WO2008103849A4 (en) 2009-01-22

Family

ID=39710749

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/054613 WO2008103849A2 (en) 2005-10-28 2008-02-21 Methods and compounds for lymphoma cell detection and isolation

Country Status (1)

Country Link
WO (1) WO2008103849A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9523695B2 (en) 2011-01-14 2016-12-20 The Regents Of The University Of California Therapeutic antibodies against ROR-1 protein and methods for use of same

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010124188A1 (en) 2009-04-23 2010-10-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-human ror1 antibodies
WO2010132532A1 (en) 2009-05-15 2010-11-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services B cell surface reactive antibodies
EP2496605A1 (en) * 2009-11-02 2012-09-12 Oxford Biotherapeutics Ltd. Ror1 as therapeutic and diagnostic target
EP2513146B1 (en) 2009-12-18 2017-05-03 Kancera AB Antibodies against ror1 capable of inducing cell death of cll
GB2476293A (en) * 2009-12-18 2011-06-22 Biolnvent Internat Ab Therapeutic inhibition of ROR-1
US9242014B2 (en) 2010-06-15 2016-01-26 The Regents Of The University Of California Receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain Fv antibody fragment conjugates and methods of use thereof
WO2012045085A1 (en) * 2010-10-01 2012-04-05 Oxford Biotherapeutics Ltd. Anti-rori antibodies
KR101935088B1 (en) * 2012-08-24 2019-01-04 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis
EP2789630A1 (en) 2013-04-09 2014-10-15 EngMab AG Bispecific antibodies against CD3e and ROR1
US11952421B2 (en) 2014-10-09 2024-04-09 Bristol-Myers Squibb Company Bispecific antibodies against CD3EPSILON and ROR1
WO2017072361A1 (en) 2015-10-30 2017-05-04 Nbe-Therapeutics Ag Anti-ror1 antibodies
AU2017210327A1 (en) 2016-01-20 2018-08-09 Nbe-Therapeutics Ag ROR1 antibody compositions and related methods
CN109996544A (en) 2016-06-27 2019-07-09 加利福尼亚大学董事会 Treatment of cancer combination
WO2018014001A1 (en) 2016-07-14 2018-01-18 Fred Hutchinson Cancer Research Center Multiple bi-specific binding domain constructs with different epitope binding to treat cancer
KR102486090B1 (en) 2017-08-07 2023-01-10 엔비이-테라퓨틱스 아게 Antibody drug conjugates with high in vivo tolerance

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BASKAR S. ET AL.: "Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia", CLINICAL CANCER RESEARCH, vol. 14, no. 2, 15 January 2008 (2008-01-15), pages 396 - 404, XP009135221, DOI: doi:10.1158/1078-0432.CCR-07-1823 *
FUKUDA T. ET AL.: "Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE, USA, vol. 105, no. 8, 19 February 2008 (2008-02-19), pages 3047 - 3052, XP009135222, DOI: doi:10.1073/pnas.0712148105 *
KATOH M.: "WNT/PCP signaling pathway and human cancer (review)", ONCOLOGY REPORTS, vol. 14, no. 6, December 2005 (2005-12-01), pages 1583 - 1588, XP009104214 *
MASIAKOWSKI P. AND CARROLL R.D.: "A novel family of cell surface receptors with tyrosine kinase-like domain", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 36, 25 December 1992 (1992-12-25), pages 26181 - 26190, XP002266720 *
PAGANONI S. AND FERREIRA A.: "Expression and subcellular localization of Ror tyrosine kinase receptors are developmentially regulated in cultured hippocampal neurons", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 73, 15 August 2003 (2003-08-15), pages 429 - 440 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9523695B2 (en) 2011-01-14 2016-12-20 The Regents Of The University Of California Therapeutic antibodies against ROR-1 protein and methods for use of same

Also Published As

Publication number Publication date
WO2008103849A2 (en) 2008-08-28
WO2008103849A4 (en) 2009-01-22

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