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WO2008102861A1 - Ｌ－アミノ酸の製造法 - Google Patents

Ｌ－アミノ酸の製造法 Download PDF

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Publication number
WO2008102861A1
WO2008102861A1 PCT/JP2008/053020 JP2008053020W WO2008102861A1 WO 2008102861 A1 WO2008102861 A1 WO 2008102861A1 JP 2008053020 W JP2008053020 W JP 2008053020W WO 2008102861 A1 WO2008102861 A1 WO 2008102861A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
producing
glycerol
culturing
activities
Prior art date
Application number
PCT/JP2008/053020
Other languages
English (en)
French (fr)
Inventor
Yuri Nagai
Kazuyuki Hayashi
Takuji Ueda
Yoshihiro Usuda
Kazuhiko Matsui
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Priority to RU2009135235/10A priority Critical patent/RU2515044C2/ru
Priority to BRPI0807756-8A priority patent/BRPI0807756B1/pt
Priority to CA002689046A priority patent/CA2689046A1/en
Priority to CN2008800059582A priority patent/CN101631871B/zh
Priority to EP08711794.1A priority patent/EP2113570A4/en
Priority to MX2009009025A priority patent/MX2009009025A/es
Publication of WO2008102861A1 publication Critical patent/WO2008102861A1/ja
Priority to US12/545,966 priority patent/US8512987B2/en
Priority to US13/938,601 priority patent/US20130288313A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L-アミノ酸生産能を有し、グリセロールデヒドロゲナーゼ及びジハイドロキシアセトンキナーゼの活性を増強するように改変された腸内細菌科に属する微生物を、グリセロールを炭素源として含む培地に培養し、L-アミノ酸を生産する。
PCT/JP2008/053020 2007-02-22 2008-02-22 Ｌ－アミノ酸の製造法 WO2008102861A1 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
RU2009135235/10A RU2515044C2 (ru) 2007-02-22 2008-02-22 Способ получения l-аминокислоты
BRPI0807756-8A BRPI0807756B1 (pt) 2007-02-22 2008-02-22 Método para produzir l-lisina e/ou l-treonina
CA002689046A CA2689046A1 (en) 2007-02-22 2008-02-22 Method of producing l-amino acid
CN2008800059582A CN101631871B (zh) 2007-02-22 2008-02-22 L-氨基酸的生产方法
EP08711794.1A EP2113570A4 (en) 2007-02-22 2008-02-22 PROCESS FOR PRODUCTION OF L-AMINO ACID
MX2009009025A MX2009009025A (es) 2007-02-22 2008-02-22 Metodo para producir l-aminoacidos.
US12/545,966 US8512987B2 (en) 2007-02-22 2009-08-24 Method of producing L-amino acid
US13/938,601 US20130288313A1 (en) 2007-02-22 2013-07-10 Method of Producing L-Amino Acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-041724 2007-02-22
JP2007041724A JP2010110217A (ja) 2007-02-22 2007-02-22 Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/545,966 Continuation US8512987B2 (en) 2007-02-22 2009-08-24 Method of producing L-amino acid

Publications (1)

Publication Number Publication Date
WO2008102861A1 true WO2008102861A1 (ja) 2008-08-28

Family

ID=39710132

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053020 WO2008102861A1 (ja) 2007-02-22 2008-02-22 Ｌ－アミノ酸の製造法

Country Status (10)

Country Link
US (2) US8512987B2 (ja)
EP (1) EP2113570A4 (ja)
JP (1) JP2010110217A (ja)
KR (1) KR20100014538A (ja)
CN (2) CN103642863A (ja)
BR (1) BRPI0807756B1 (ja)
CA (1) CA2689046A1 (ja)
MX (1) MX2009009025A (ja)
RU (1) RU2515044C2 (ja)
WO (1) WO2008102861A1 (ja)

Cited By (12)

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Publication number Priority date Publication date Assignee Title
WO2009093703A1 (ja) 2008-01-23 2009-07-30 Ajinomoto Co., Inc. Ｌ-アミノ酸の製造法
EP2202299A1 (en) 2008-12-22 2010-06-30 Ajinomoto Co., Inc. A method for producing L-lysine
WO2010084995A2 (en) 2009-01-23 2010-07-29 Ajinomoto Co.,Inc. A method for producing an l-amino acid
US7833761B2 (en) 2007-09-04 2010-11-16 Ajinomoto Co., Inc. Amino acid producing microorganism and a method for producing an amino acid
WO2011013707A1 (ja) 2009-07-29 2011-02-03 味の素株式会社 Ｌ-アミノ酸の製造法
WO2011024555A1 (ja) 2009-08-28 2011-03-03 味の素株式会社 Ｌ－アミノ酸の製造法
WO2011055710A1 (ja) 2009-11-06 2011-05-12 味の素株式会社 Ｌ－アミノ酸の製造法
WO2011096554A1 (ja) 2010-02-08 2011-08-11 味の素株式会社 変異型ｒｐｓＡ遺伝子及びＬ－アミノ酸の製造法
WO2011102305A2 (en) 2010-02-18 2011-08-25 Ajinomoto Co.,Inc. A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE Enterobacteriaceae FAMILY HAVING A MUTANT ADENYLATE CYCLASE
WO2012077739A1 (ja) 2010-12-10 2012-06-14 味の素株式会社 Ｌ－アミノ酸の製造法
US8679798B2 (en) 2007-12-21 2014-03-25 Ajinomoto Co., Inc. Method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family
US20140113342A1 (en) * 2012-10-18 2014-04-24 Algenol Biofuels Inc. Production of 1,2-Propanediol in Cyanobacteria

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US7915018B2 (en) 2004-10-22 2011-03-29 Ajinomoto Co., Inc. Method for producing L-amino acids using bacteria of the Enterobacteriaceae family
WO2007119574A2 (en) * 2006-03-23 2007-10-25 Ajinomoto Co., Inc. A method for producing an l-amino acid using bacterium of the enterobacteriaceae family with attenuated expression of a gene coding for small rna
JP2010110217A (ja) * 2007-02-22 2010-05-20 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
EP2147970B1 (en) 2007-04-17 2014-12-31 Ajinomoto Co., Inc. A method for producing an acidic substance having a carboxyl group
JP2010226957A (ja) 2007-10-17 2010-10-14 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2011167071A (ja) * 2008-05-22 2011-09-01 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
EP2343371B1 (en) 2008-09-05 2015-10-21 Ajinomoto Co., Inc. Method for producing l-amino acid
US8980604B2 (en) * 2009-07-30 2015-03-17 Metabolic Explorer Mutant glycerol dehydrogenase (GlyDH) for the production of a biochemical by fermentation
RU2471870C2 (ru) 2010-06-03 2013-01-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА И L-ЦИТРУЛЛИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНА pepA
JP6020443B2 (ja) * 2011-04-01 2016-11-02 味の素株式会社 Ｌ−システインの製造法
EP2708598A1 (en) * 2012-09-14 2014-03-19 Basf Se Serinol production in glycerol catabolism deficient escherichia coli strains
CN103146772B (zh) * 2013-02-08 2014-06-18 宁夏伊品生物科技股份有限公司 用乌头酸酶表达弱化和/或酶活性降低的细菌发酵生产l-赖氨酸的方法
DK2824186T3 (en) 2013-02-08 2018-07-23 Ningxia Eppen Biotech Co Ltd L-light generation method using fermentation bacteria with modified aconitic gene and / or regulatory element
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KR101500073B1 (ko) * 2013-04-23 2015-03-06 씨제이제일제당 (주) L-아르기닌 생산능이 향상된 코리네박테리움속 미생물 및 이를 이용한 l-아르기닌의 생산 방법
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