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WO2008015383A8 - Bmp-9 and bmp-10 and their use in breast and prostate cancer therapies - Google Patents

Bmp-9 and bmp-10 and their use in breast and prostate cancer therapies Download PDF

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Publication number
WO2008015383A8
WO2008015383A8 PCT/GB2007/002755 GB2007002755W WO2008015383A8 WO 2008015383 A8 WO2008015383 A8 WO 2008015383A8 GB 2007002755 W GB2007002755 W GB 2007002755W WO 2008015383 A8 WO2008015383 A8 WO 2008015383A8
Authority
WO
WIPO (PCT)
Prior art keywords
bmp
breast
prostate cancer
cancer therapies
therapies
Prior art date
Application number
PCT/GB2007/002755
Other languages
French (fr)
Other versions
WO2008015383A2 (en
WO2008015383A3 (en
Inventor
Wen Guo Jiang
Original Assignee
Univ Cardiff
Wen Guo Jiang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cardiff, Wen Guo Jiang filed Critical Univ Cardiff
Publication of WO2008015383A2 publication Critical patent/WO2008015383A2/en
Publication of WO2008015383A3 publication Critical patent/WO2008015383A3/en
Publication of WO2008015383A8 publication Critical patent/WO2008015383A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates to the role of BMP-9 and/or BMP-10 in the treatment of breast or prostate cancer.
PCT/GB2007/002755 2006-07-29 2007-07-20 Bmp-9 and bmp-10 and their use in breast and prostate cancer therapies WO2008015383A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0615129.4 2006-07-29
GBGB0615129.4A GB0615129D0 (en) 2006-07-29 2006-07-29 Anti-cancer activity of BMP-9 and BMP-10 and their use in cancer therapies

Publications (3)

Publication Number Publication Date
WO2008015383A2 WO2008015383A2 (en) 2008-02-07
WO2008015383A3 WO2008015383A3 (en) 2008-08-14
WO2008015383A8 true WO2008015383A8 (en) 2009-07-16

Family

ID=37006438

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/002755 WO2008015383A2 (en) 2006-07-29 2007-07-20 Bmp-9 and bmp-10 and their use in breast and prostate cancer therapies

Country Status (2)

Country Link
GB (1) GB0615129D0 (en)
WO (1) WO2008015383A2 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2574777C (en) 2004-07-23 2015-09-01 Acceleron Pharma Inc. Actrii receptor polypeptides, methods and compositions
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
EP2329837B1 (en) 2005-11-23 2014-04-30 Acceleron Pharma Inc. Anti-activin A or B antibodies and use thereof for promoting bone growth
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
AU2008211007B2 (en) 2007-02-01 2013-09-19 Acceleron Pharma Inc. Activin-ActRIIa antagonists and uses for treating or preventing breast cancer
TW202104248A (en) 2007-02-02 2021-02-01 美商艾瑟勒朗法瑪公司 Variants derived from actriib and uses therefor
KR20190026047A (en) 2007-02-09 2019-03-12 악셀레론 파마 인코포레이티드 Activin-actriia antagonists and uses for promoting bone growth in cancer patients
WO2009038745A1 (en) 2007-09-18 2009-03-26 Acceleron Pharma Inc. Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion
WO2009084738A1 (en) * 2007-12-28 2009-07-09 Kyowa Hakko Kirin Co., Ltd. Method and pharmaceutical composition for treatment of cancer using bmp9 protein
WO2009084739A1 (en) * 2007-12-28 2009-07-09 Kyowa Hakko Kirin Co., Ltd. Method and pharmaceutical composition for treatment of cancer using bmp10 protein,
JP5922928B2 (en) 2008-08-14 2016-05-24 アクセルロン ファーマ， インコーポレイテッド Use of GDF traps to increase red blood cell levels
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
US8138142B2 (en) 2009-01-13 2012-03-20 Acceleron Pharma Inc. Methods for increasing adiponectin in a patient in need thereof
CN104840944A (en) 2009-06-08 2015-08-19 阿塞勒隆制药公司 Methods for increasing thermogenic adipocytes
CA2765108C (en) 2009-06-12 2020-09-15 Acceleron Pharma Inc. Truncated actriib-fc fusion proteins
CA2781152A1 (en) 2009-11-17 2011-05-26 Acceleron Pharma Inc. Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
EP2638065A4 (en) 2010-11-08 2014-04-09 Acceleron Pharma Inc Actriia binding agents and uses thereof
US9809636B2 (en) * 2012-04-06 2017-11-07 Acceleron Pharma Inc. Methods for increasing red blood cell levels comprising administering BMP9
CA3120678A1 (en) 2012-11-02 2014-05-08 Celgene Corporaiton Activin-actrii antagonists and uses for treating bone and other disorders
MA40008A (en) 2014-06-13 2021-05-05 Acceleron Pharma Inc ANTAGONIST ACTRII FOR THE TREATMENT AND PREVENTION OF SKIN ULCER IN A SUBJECT WITH ANEMIA
MA41052A (en) 2014-10-09 2017-08-15 Celgene Corp TREATMENT OF CARDIOVASCULAR DISEASE USING ACTRII LIGAND TRAPS
HRP20230504T1 (en) 2014-12-03 2023-09-15 Celgene Corporation Activin-actrii antagonists and uses for treating myelodysplastic syndrome
AU2016311298A1 (en) 2015-08-25 2018-02-08 Histide Ag Compounds for inducing tissue formation and uses thereof
JP7236134B2 (en) * 2015-09-17 2023-03-09 ヒスタイド アクツィエンゲゼルシャフト Pharmaceutical conjugation and use thereof for converting tumor cells to non-tumor cells
AU2016323408A1 (en) * 2015-09-17 2018-04-19 Histide Ag Pharmaceutical association of growth factor receptor agonist and adhesion protein inhibitor for converting a neoplastic cell into a non-neoplastic cell and uses thereof
WO2023069447A1 (en) * 2021-10-18 2023-04-27 The Uab Research Foundation Bmp9 or an agonist thereof and its uses related to reducing metastasis of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1131087E (en) * 1998-11-13 2004-12-31 Curis Inc METHODS OF RELIEF OF CANCER SYMPTOMS
US20060039949A1 (en) * 2004-08-20 2006-02-23 Nycz Jeffrey H Acetabular cup with controlled release of an osteoinductive formulation
EP1802326A2 (en) * 2004-09-09 2007-07-04 Stryker Corporation Methods for treating bone tumors using bone morphogenic proteins

Also Published As

Publication number Publication date
GB0615129D0 (en) 2006-09-06
WO2008015383A2 (en) 2008-02-07
WO2008015383A3 (en) 2008-08-14

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