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WO2008099072A3 - Nouveaux derives de 2, 4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk - Google Patents

Nouveaux derives de 2, 4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk Download PDF

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Publication number
WO2008099072A3
WO2008099072A3 PCT/FR2008/000001 FR2008000001W WO2008099072A3 WO 2008099072 A3 WO2008099072 A3 WO 2008099072A3 FR 2008000001 W FR2008000001 W FR 2008000001W WO 2008099072 A3 WO2008099072 A3 WO 2008099072A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
optionally substituted
drugs
dianilinopyrimidines
essentially
Prior art date
Application number
PCT/FR2008/000001
Other languages
English (en)
Other versions
WO2008099072A2 (fr
Inventor
Michael Bosch
Monsif Bouaboula
Pierre Casellas
Jean-Flaubert Nguefack
Bernard Tonnerre
Jean Wagnon
Original Assignee
Sanofi Aventis
Michael Bosch
Monsif Bouaboula
Pierre Casellas
Jean-Flaubert Nguefack
Bernard Tonnerre
Jean Wagnon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis, Michael Bosch, Monsif Bouaboula, Pierre Casellas, Jean-Flaubert Nguefack, Bernard Tonnerre, Jean Wagnon filed Critical Sanofi Aventis
Priority to JP2009544425A priority Critical patent/JP2010514820A/ja
Priority to CA002672955A priority patent/CA2672955A1/fr
Priority to EP08750460A priority patent/EP2104673A2/fr
Publication of WO2008099072A2 publication Critical patent/WO2008099072A2/fr
Publication of WO2008099072A3 publication Critical patent/WO2008099072A3/fr
Priority to US12/495,992 priority patent/US20100035907A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne les produits de formule (I) : dans laquelle R2, R3 et R4, représente l'un HaI ou CF3 et les deux autres, H, HaI ou alkyle et alcoxy éventuellement substitués par un ou plusieurs HaI; R1 représente H, cycloalkyle, alkyle, alkényle ou alkynyle, tous éventuellement substitués; A représente simple liaison ou -CH2-CO-NR6- avec Rβ est choisi parmi les valeurs de R1; le cycle renfermant Y (ou cycle (Y) ) étant monocyclique ou bicyclique, constitué de 4 à 10 chaînons avec Y représente O, S, SO, SO2, N-R7 (cycle (Y) pouvant renfermant un pont carboné), C=O ou son dioxolanne, CF2, CH-OR8, CH-NR8R9; et R7 représente hydrogène, cycloalkyle, alkyle, CH2-alkényle ou CH2- alkynyle, éventuellement substitués; R8 représente hydrogène, alkyle, cycloalkyle ou hétérocycloalkyle éventuellement substitués; ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments notamment comme inhibiteurs de IKK.
PCT/FR2008/000001 2007-01-05 2008-01-02 Nouveaux derives de 2, 4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk WO2008099072A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009544425A JP2010514820A (ja) 2007-01-05 2008-01-02 新規な２，４−ジアニリノピリミジン類、薬剤としてのこれらの調製、医薬組成物および基本的にｉｋｋ阻害剤としてのこれらの使用
CA002672955A CA2672955A1 (fr) 2007-01-05 2008-01-02 Nouveaux derives de 2,4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
EP08750460A EP2104673A2 (fr) 2007-01-05 2008-01-02 Nouveaux derives de 2, 4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
US12/495,992 US20100035907A1 (en) 2007-01-05 2009-07-01 New 2,4-dianilinopyrimidines, preparation thereof as drugs, pharmaceutical compositions and use thereof essentially as ikk inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0700063A FR2911137B1 (fr) 2007-01-05 2007-01-05 Nouveaux derives de 2,4-dianilinopyrimides, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
FR0700063 2007-01-05

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/495,992 Continuation US20100035907A1 (en) 2007-01-05 2009-07-01 New 2,4-dianilinopyrimidines, preparation thereof as drugs, pharmaceutical compositions and use thereof essentially as ikk inhibitors

Publications (2)

Publication Number Publication Date
WO2008099072A2 WO2008099072A2 (fr) 2008-08-21
WO2008099072A3 true WO2008099072A3 (fr) 2008-11-13

Family

ID=38353639

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/000001 WO2008099072A2 (fr) 2007-01-05 2008-01-02 Nouveaux derives de 2, 4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk

Country Status (11)

Country Link
US (1) US20100035907A1 (fr)
EP (1) EP2104673A2 (fr)
JP (1) JP2010514820A (fr)
CN (1) CN101605780A (fr)
AR (1) AR064729A1 (fr)
CA (1) CA2672955A1 (fr)
CL (1) CL2008000021A1 (fr)
FR (1) FR2911137B1 (fr)
TW (1) TW200836740A (fr)
UY (1) UY30856A1 (fr)
WO (1) WO2008099072A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2911138B1 (fr) * 2007-01-05 2009-02-20 Sanofi Aventis Sa Nouveaux derives de n, n'-2,4-dianilinopyrimidines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
FR2911140B1 (fr) * 2007-01-05 2009-02-20 Sanofi Aventis Sa Nouveaux derives de 2-anilino 4-heteroaryle pyrimides, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
FR2911139A1 (fr) * 2007-01-05 2008-07-11 Sanofi Aventis Sa Nouveaux derives de phenyl-(4-phenyl-pyrimidin-2-yl)amines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
WO2011157827A1 (fr) 2010-06-18 2011-12-22 Sanofi Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
EP2760862B1 (fr) 2011-09-27 2015-10-21 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
US11175268B2 (en) 2014-06-09 2021-11-16 Biometry Inc. Mini point of care gas chromatographic test strip and method to measure analytes
US11435340B2 (en) 2014-06-09 2022-09-06 Biometry Inc. Low cost test strip and method to measure analyte
WO2017009751A1 (fr) 2015-07-15 2017-01-19 Pfizer Inc. Dérivés de pyrimidine
EP3487407B1 (fr) 2016-07-19 2024-10-02 Biometry Inc. Procédés et systèmes de mesure d'analytes à l'aide de bandelettes réactives pouvant être étalonnées par lots
CN113061117B (zh) * 2021-03-30 2023-02-10 长治学院 一种2-((5-氯-2-(4-吗啉甲基苯胺基)嘧啶-4-基)氨基)苯甲酰胺衍生物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004046118A2 (fr) * 2002-05-06 2004-06-03 Bayer Pharmaceuticals Corporation Derives de 2-4-(di-phenyl-amino)-pyrimidine convenant pour traiter des pathologies hyper-proliferantes
US20050261295A1 (en) * 2004-05-19 2005-11-24 Boehringer Ingelheim International Gmbh Pyrimidine as PLK inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009501711A (ja) * 2005-07-11 2009-01-22 サノフイ−アベンテイス 新規２，４−ジアニリノピリミジン誘導体、その調製、医薬、医薬組成物としての、特に、ｉｋｋ阻害剤としてのそれらの使用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004046118A2 (fr) * 2002-05-06 2004-06-03 Bayer Pharmaceuticals Corporation Derives de 2-4-(di-phenyl-amino)-pyrimidine convenant pour traiter des pathologies hyper-proliferantes
US20050261295A1 (en) * 2004-05-19 2005-11-24 Boehringer Ingelheim International Gmbh Pyrimidine as PLK inhibitors

Also Published As

Publication number Publication date
JP2010514820A (ja) 2010-05-06
TW200836740A (en) 2008-09-16
FR2911137B1 (fr) 2009-02-20
WO2008099072A2 (fr) 2008-08-21
EP2104673A2 (fr) 2009-09-30
US20100035907A1 (en) 2010-02-11
CN101605780A (zh) 2009-12-16
CA2672955A1 (fr) 2008-08-21
CL2008000021A1 (es) 2009-03-27
UY30856A1 (es) 2008-09-02
AR064729A1 (es) 2009-04-22
FR2911137A1 (fr) 2008-07-11

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