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WO2008090465A3 - Process for synthesizing desvenlafaxine free base and salts or salvates thereof - Google Patents

Process for synthesizing desvenlafaxine free base and salts or salvates thereof Download PDF

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Publication number
WO2008090465A3
WO2008090465A3 PCT/IB2008/000472 IB2008000472W WO2008090465A3 WO 2008090465 A3 WO2008090465 A3 WO 2008090465A3 IB 2008000472 W IB2008000472 W IB 2008000472W WO 2008090465 A3 WO2008090465 A3 WO 2008090465A3
Authority
WO
WIPO (PCT)
Prior art keywords
free base
salts
salvates
synthesizing
desvenlafaxine
Prior art date
Application number
PCT/IB2008/000472
Other languages
French (fr)
Other versions
WO2008090465A2 (en
Inventor
I Llado Jordi Bosch
Original Assignee
Medichem Sa
I Llado Jordi Bosch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa, I Llado Jordi Bosch filed Critical Medichem Sa
Publication of WO2008090465A2 publication Critical patent/WO2008090465A2/en
Publication of WO2008090465A3 publication Critical patent/WO2008090465A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The invention relates to a process for manufacturing desvenlafaxine free base and salts or solvates thereof, comprising O-demethylating venlafaxine by treatment with 2- (diethylamino) ethanethiol free base or its hydrochloride salt.
PCT/IB2008/000472 2007-01-22 2008-01-22 Process for synthesizing desvenlafaxine free base and salts or salvates thereof WO2008090465A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88146707P 2007-01-22 2007-01-22
US60/881,467 2007-01-22

Publications (2)

Publication Number Publication Date
WO2008090465A2 WO2008090465A2 (en) 2008-07-31
WO2008090465A3 true WO2008090465A3 (en) 2008-09-12

Family

ID=39587010

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/000472 WO2008090465A2 (en) 2007-01-22 2008-01-22 Process for synthesizing desvenlafaxine free base and salts or salvates thereof

Country Status (2)

Country Link
AR (1) AR064987A1 (en)
WO (1) WO2008090465A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011500777A (en) * 2007-10-26 2011-01-06 ジェネリクス・（ユーケー）・リミテッド Method for producing O-desmethylvenlafaxine
CZ200969A3 (en) * 2009-02-06 2010-06-30 Zentiva, K.S. Novel salts of desvenlafaxine and process of their preparation
EP2394976A1 (en) 2010-06-11 2011-12-14 LEK Pharmaceuticals d.d. Process for demethylating aromatic methyl ethers using 3-mercaptopropionic acid

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US668912A (en) * 1900-12-08 1901-02-26 Peter Fitz Randolph Seed-planter and fertilizer-distributer.
EP0112669A2 (en) * 1982-12-13 1984-07-04 American Home Products Corporation Phenethylamine derivatives and intermediates therefor
US6673838B2 (en) * 2001-02-12 2004-01-06 Wyeth Succinate salt of O-desmethyl-venlafaxine
US20050197392A1 (en) * 1999-04-06 2005-09-08 Sepracor Inc. O-desmethylvenlafaxine and methods of preparing and using the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US668912A (en) * 1900-12-08 1901-02-26 Peter Fitz Randolph Seed-planter and fertilizer-distributer.
EP0112669A2 (en) * 1982-12-13 1984-07-04 American Home Products Corporation Phenethylamine derivatives and intermediates therefor
US20050197392A1 (en) * 1999-04-06 2005-09-08 Sepracor Inc. O-desmethylvenlafaxine and methods of preparing and using the same
US6673838B2 (en) * 2001-02-12 2004-01-06 Wyeth Succinate salt of O-desmethyl-venlafaxine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MAGANO ET AL: "2-(Diethyamino)ethanethiol, a New Reagent for the Odorless Deprotection of Aromatic Methyl Ethers", J. ORG. CHEM., vol. 71, 2006, pages 7103 - 7105, XP002487903 *

Also Published As

Publication number Publication date
AR064987A1 (en) 2009-05-06
WO2008090465A2 (en) 2008-07-31

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