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WO2008079400A3 - Surgical applications for bmp binding protein - Google Patents

Surgical applications for bmp binding protein Download PDF

Info

Publication number
WO2008079400A3
WO2008079400A3 PCT/US2007/026315 US2007026315W WO2008079400A3 WO 2008079400 A3 WO2008079400 A3 WO 2008079400A3 US 2007026315 W US2007026315 W US 2007026315W WO 2008079400 A3 WO2008079400 A3 WO 2008079400A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding protein
surgical applications
bmp binding
surgical
bone
Prior art date
Application number
PCT/US2007/026315
Other languages
French (fr)
Other versions
WO2008079400A2 (en
Inventor
Samuel S Murray
Elsa J Murray
Keyvan Behnam
Jeffrey C Wang
Original Assignee
Univ California
Us Dept Veterans Affairs
Samuel S Murray
Elsa J Murray
Keyvan Behnam
Jeffrey C Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/985,745 external-priority patent/US8193312B2/en
Application filed by Univ California, Us Dept Veterans Affairs, Samuel S Murray, Elsa J Murray, Keyvan Behnam, Jeffrey C Wang filed Critical Univ California
Priority to JP2009542969A priority Critical patent/JP5466017B2/en
Priority to US12/448,497 priority patent/US8415302B2/en
Priority to AU2007338627A priority patent/AU2007338627B2/en
Priority to EP07868028A priority patent/EP2115465A4/en
Priority to CA002673600A priority patent/CA2673600A1/en
Publication of WO2008079400A2 publication Critical patent/WO2008079400A2/en
Publication of WO2008079400A3 publication Critical patent/WO2008079400A3/en
Priority to US13/857,711 priority patent/US9050300B2/en
Priority to US14/731,852 priority patent/US9610320B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.
PCT/US2007/026315 2004-01-28 2007-12-26 Surgical applications for bmp binding protein WO2008079400A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2009542969A JP5466017B2 (en) 2006-12-22 2007-12-26 Surgical application for BMP binding proteins
US12/448,497 US8415302B2 (en) 2004-01-28 2007-12-26 Surgical applications for BMP binding protein
AU2007338627A AU2007338627B2 (en) 2006-12-22 2007-12-26 Surgical applications for BMP binding protein
EP07868028A EP2115465A4 (en) 2006-12-22 2007-12-26 Surgical applications for bmp binding protein
CA002673600A CA2673600A1 (en) 2006-12-22 2007-12-26 Surgical applications for bmp binding protein
US13/857,711 US9050300B2 (en) 2004-01-28 2013-04-05 Surgical applications for BMP binding protein
US14/731,852 US9610320B2 (en) 2004-01-28 2015-06-05 Surgical applications for BMP binding protein

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US87682106P 2006-12-22 2006-12-22
US60/876,821 2006-12-22
US11/985,745 2007-11-16
US11/985,745 US8193312B2 (en) 2004-01-28 2007-11-16 Bone morphogenic protein binding peptide

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11/985,745 Continuation-In-Part US8193312B2 (en) 2004-01-28 2007-11-16 Bone morphogenic protein binding peptide

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/448,497 A-371-Of-International US8415302B2 (en) 2004-01-28 2007-12-26 Surgical applications for BMP binding protein
US13/857,711 Continuation US9050300B2 (en) 2004-01-28 2013-04-05 Surgical applications for BMP binding protein

Publications (2)

Publication Number Publication Date
WO2008079400A2 WO2008079400A2 (en) 2008-07-03
WO2008079400A3 true WO2008079400A3 (en) 2008-08-21

Family

ID=39563120

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/026315 WO2008079400A2 (en) 2004-01-28 2007-12-26 Surgical applications for bmp binding protein

Country Status (5)

Country Link
EP (1) EP2115465A4 (en)
JP (1) JP5466017B2 (en)
AU (1) AU2007338627B2 (en)
CA (1) CA2673600A1 (en)
WO (1) WO2008079400A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8415302B2 (en) 2004-01-28 2013-04-09 The Regents Of The University Of California Surgical applications for BMP binding protein
US8193312B2 (en) * 2004-01-28 2012-06-05 The Regents Of The University Of California Bone morphogenic protein binding peptide
US8188219B2 (en) 2004-01-28 2012-05-29 The Regents Of The University Of California Bone morphogenic protein binding peptide
CA2589930C (en) 2004-11-29 2016-10-11 The Regents Of The University Of California Activating extraction of demineralized bone matrix
MX2012000214A (en) 2009-06-23 2012-01-25 Univ California Enhancement of bmp retention.
JP2018525446A (en) * 2015-08-25 2018-09-06 ヒスタイド アクツィエンゲゼルシャフト Tissue formation inducing compound and use thereof
AU2016311300B2 (en) * 2015-08-25 2021-07-29 Histide Ag Compounds for inducing tissue formation and uses thereof
EP3833377B1 (en) * 2018-08-10 2023-11-22 Alexion Pharmaceuticals, Inc. Bone healing at implants using alkaline phosphatase
CN117042791A (en) 2021-02-12 2023-11-10 阿雷克森制药公司 Alkaline phosphatase polypeptides and methods of use thereof
EP4367131A1 (en) * 2021-07-05 2024-05-15 Universiteit Maastricht Means and methods for the treatment of calcium crystal deposition diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005072403A2 (en) * 2004-01-28 2005-08-11 The Regents Of The University Of California Bone morphogenic protein binding peptide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2020729A1 (en) * 1989-07-19 1991-01-20 Michael C. Kiefer Bone morphogenetic protein
CA2589930C (en) * 2004-11-29 2016-10-11 The Regents Of The University Of California Activating extraction of demineralized bone matrix

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005072403A2 (en) * 2004-01-28 2005-08-11 The Regents Of The University Of California Bone morphogenic protein binding peptide

Also Published As

Publication number Publication date
EP2115465A2 (en) 2009-11-11
EP2115465A4 (en) 2011-08-10
CA2673600A1 (en) 2008-07-03
AU2007338627B2 (en) 2013-08-15
JP5466017B2 (en) 2014-04-09
WO2008079400A2 (en) 2008-07-03
AU2007338627A2 (en) 2010-01-28
AU2007338627A1 (en) 2008-07-03
JP2010513535A (en) 2010-04-30

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