WO2007108710A1 - A method of manufacturing a test for the detection of narcotics, particularly gamma- hydroxybutiric acid (ghb), and a method of detecting their presence - Google Patents
A method of manufacturing a test for the detection of narcotics, particularly gamma- hydroxybutiric acid (ghb), and a method of detecting their presence Download PDFInfo
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- WO2007108710A1 WO2007108710A1 PCT/PL2007/000013 PL2007000013W WO2007108710A1 WO 2007108710 A1 WO2007108710 A1 WO 2007108710A1 PL 2007000013 W PL2007000013 W PL 2007000013W WO 2007108710 A1 WO2007108710 A1 WO 2007108710A1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/02—Food
- G01N33/14—Beverages
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
Definitions
- the subject of the present invention is a method of manufacturing a test for the detection of narcotics, particularly gamma-hydroxybutiric acid (GHB) as well as a method of detecting the presence of a narcotic, particularly gamma-hydroxybutiric acid.
- GLB gamma-hydroxybutiric acid
- GHB and its salts are psychoactive agents with sedative and hypnotic activity, being category IV-P psychotropic substances, narcotics used as "club narcotics” and also counted among the "date rape drugs” which are very popular due to their ease of distribution in the form of small tablets, powder or liquid.
- tests and detection methods of discovering the presence of the narcotic, particularly GHB consist of colorimetric tests such as 5% FeCl 3 /H 2 O which upon reaction with GHB forms a brown precipitate; saturated K 2 Cr 2 O 7 , which upon reaction with GHB yields a yellow to brown colour; 1% Co(NO 3 ) 2 /ethanol, which upon reaction with GHB yields a pink to violet colour; as well as cobalt thiocyanate/toluene, which upon reaction with GHB yields a blue colour.
- the method of manufacturing extant tests is based on making aqueous or ethanolic solutions of reagents, chemical compounds which react with GHB.
- the detection of the presence of a narcotic, particularly GHB, with said tests consists of eliciting selective or specific chromogenic reactions with the narcotic, particularly GHB, with the chemical reagent.
- the goal of the present invention is the design of a method of manufacturing a test for the detection of narcotics, particularly GHB, of a screening nature which will facilitate the identification of this "clubbing narcotic" and particularly facilitating it via chromogenic reactions of GHB or its sodium or potasium salts, both in their pure form as well as in aqueous and ethanolic dispersions and various drinks.
- the method of manufacturing a test for the detection of narcotics according to the present invention is characterised in that 2 to 5 parts by mass of bromocresol green are mixed with 100 to 180 parts by mass of amine salts, 150 to 210 parts by mass of sugar, 3000 to 6000 parts by mass of water and 18000 to 26000 parts by mass of alcohol, where the solution obtained is brought to a pH of 1 to 4 using a nonvolatile acid.
- a primary aliphatic amine salt is used, preferentially diethylamine dihydrochloride.
- glucose may be used as the sugar, methanol or ethanol as the alcohol and citric acid as the non-volatile acid.
- the surface onto which the solution is deposited according to the present invention is glass, porcelain or a plastic.
- the method of manufacturing a test for the detection of narcotics, particularly GHB in the substance being tested facilitates the detection of a positive result particularly in tap water, tea, pale beer, particularly with 5.6% alcohol content, 40% vodka, 40% whisky, 30% liqueurs, 40% rum, 40% cognac and 96% spirit and furthermore in clear, relatively lightly coloured drinks, particularly those with pale gold or amber hues.
- a further advantage of a test manufactured according to the present invention is that it is possible to use it to detect the presence of GHB in substances containing other narcotics, particularly amphetamine and its derivatives, methamphetamine and its derivatives, ephedrine, alcaloids, opium, LSD, cocaine, benzyldiazepines, PCP and anabolic steroids.
- the test for detecting narcotics, particularly GHB, manufactured according to the present invention is of a screening nature, facilitating the identification of this "club narcotic" particularly by way of the chromogenic reactions of GHB, its sodium or potassium salts, in their pure form as well as in aqueous and ethanolic dispersions and various drinks.
- test obtained according to the present invention is specific, characterised by high sensitivity and immune to interference by alcohols, sugars and chloride ions, including those found in alcoholic or soft drinks; which facilitates the detection of the presence of the narcotic through simple and easy application on site, wherein the test is performed over a time not exceeding 120 seconds.
- Example I The method of manufacturing the test according to the present invention as well as the method of detecting a narcotic, particularly GHB, according to the present invention is presented in example embodiments.
- Example I The method of manufacturing the test according to the present invention as well as the method of detecting a narcotic, particularly GHB, according to the present invention is presented in example embodiments.
- Example I The method of manufacturing the test according to the present invention as well as the method of detecting a narcotic, particularly GHB, according to the present invention is presented in example embodiments.
- the test is produced through mixing 0.03 parts by mass (pbm) of bromocresol green, 0.01 pbm methyl orange, 1.7 pbm glucose, 1.3 pbm diethylamine dihydrochloride, 35 pbm water and 185 pbm methanol, whereafter the solution is brought to pH 2.7 with
- the test is produced through mixing 0.03 parts by mass (pbm) of bromocresol green,
- test solution prepared in this manner 0.1 ml are transferred onto a glass plate and then dried at 50°C.
- test solution prepared in this manner 0.1 ml are transferred onto a glass plate and then dried at 55°C.
- test solution prepared in this manner 0.1 ml are transferred onto a polyethylene-coated cellulose wafer and then dried at 25°C.
- a 0.2 ml sample of beer are placed onto the test field, previously treated with 0.1 ml of test solution and dried.
- test solution on the test field will assume a yellow-green hue demonstrating the presence of said narcotic in the sample of beer.
- test solution 0.5 ml of the test solution are supplemented with 1 ml of beer.
- test solution assume a yellow-green hue demonstrating the presence of said narcotic in the sample of beer.
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Abstract
A method of manufacturing a test for the detection of narcotics, particularly gamma hydroxybutiric acid (GHB), based on the mixing and preferentially drying of components, characterised in that 2 to 5 parts by mass of bromocresol green are mixed with 100 to 180 parts by mass of amine salts, 150 to 210 parts by mass of sugar, 3000 to 6000 parts by mass of water and 18000 to 26000 parts by mass (pbm) of alcohol, where the solution obtained is brought to a pH of 1 to 4 using a non¬ volatile acid. A method of detecting narcotics, particularly GHB, according to the present invention characterised in that from 0.1 to 0.5 ml of the substance being tested are introduced into 0.05 to 0.25 ml of the test solution; or from 0.1 to 0.5 ml of the substance being tested are introduced onto the dried test.
Description
A METHOD OF MANUFACTURING A TEST FOR THE DETECTION OF NARCOTICS, PARTICULARLY GAMMA-HYDROXYBUTIRIC ACID (GHB) , AND A METHOD OF DETECTING THEIR PRESENCE
The subject of the present invention is a method of manufacturing a test for the detection of narcotics, particularly gamma-hydroxybutiric acid (GHB) as well as a method of detecting the presence of a narcotic, particularly gamma-hydroxybutiric acid.
GHB and its salts are psychoactive agents with sedative and hypnotic activity, being category IV-P psychotropic substances, narcotics used as "club narcotics" and also counted among the "date rape drugs" which are very popular due to their ease of distribution in the form of small tablets, powder or liquid.
To date, tests and detection methods of discovering the presence of the narcotic, particularly GHB, consist of colorimetric tests such as 5% FeCl3/H2O which upon reaction with GHB forms a brown precipitate; saturated K2Cr2O7, which upon reaction with GHB yields a yellow to brown colour; 1% Co(NO3)2/ethanol, which upon reaction with GHB yields a pink to violet colour; as well as cobalt thiocyanate/toluene, which upon reaction with GHB yields a blue colour.
The method of manufacturing extant tests is based on making aqueous or ethanolic solutions of reagents, chemical compounds which react with GHB. The detection of the presence of a narcotic, particularly GHB, with said tests consists of eliciting selective or specific chromogenic reactions with the narcotic, particularly GHB, with the chemical reagent.
The goal of the present invention is the design of a method of manufacturing a test for the detection of narcotics, particularly GHB, of a screening nature which will facilitate the identification of this "clubbing narcotic" and particularly facilitating it via chromogenic reactions of GHB or its sodium or potasium salts, both in their pure form as well as in aqueous and ethanolic dispersions and various drinks.
Furthermore, the next goal of the present invention is the design of a method of manufacturing a selective test, characterised by its high sensitivity, without interference from alcohols, sugars and chloride ions including those found in alcoholic or soft drinks, facilitating the detection of the presence of the narcotic through the simple and easy application of the test over a time not exceeding 120 seconds on
site, excluding drinks with strong colouring such as red wine, cola or blackcurrant juice.
The method of manufacturing a test for the detection of narcotics according to the present invention is characterised in that 2 to 5 parts by mass of bromocresol green are mixed with 100 to 180 parts by mass of amine salts, 150 to 210 parts by mass of sugar, 3000 to 6000 parts by mass of water and 18000 to 26000 parts by mass of alcohol, where the solution obtained is brought to a pH of 1 to 4 using a nonvolatile acid.
Preferentially, in the method according to the present invention, 1 to 2 parts by mass of methyl orange are added.
Furthermore, in the method according to the present invention, a primary aliphatic amine salt is used, preferentially diethylamine dihydrochloride.
In the method according to the present invention, glucose may be used as the sugar, methanol or ethanol as the alcohol and citric acid as the non-volatile acid.
Preferentially, 0.05 to 0.25 ml of the solution produced using the method according to the present invention are transferred onto a surface inert with respect to the solution and then dried at a temperature below 60°C.
Preferentially, the surface onto which the solution is deposited according to the present invention is glass, porcelain or a plastic.
The method of detecting narcotics, particularly GHB, according to the present invention is characterised in that from 0.1 to 0.5 ml of the substance being tested is introduced to the 0.05 to 0.25 ml of test.
The method of detecting the presence of a narcotic, particularly GHB, according to the present invention is characterised in that from 0.1 to 0.5 ml of the substance being tested are introduced onto the dried test.
The test for detecting narcotics, manufactured according to the present invention, both as a solution or after drying, may be used to test for GHB as well as its sodium or potassium salts, contained within commercial products as pure liquids, powders and as aqueous and aqueous/alcoholic solutions thereof.
The method of manufacturing a test for the detection of narcotics, particularly GHB in the substance being tested facilitates the detection of a positive result particularly in tap water, tea, pale beer, particularly with 5.6% alcohol content, 40% vodka, 40% whisky, 30% liqueurs, 40% rum, 40% cognac and 96% spirit and
furthermore in clear, relatively lightly coloured drinks, particularly those with pale gold or amber hues.
The advantages of detecting a narcotic according to the present invention and using the test according to the present invention is the obtainment of a positive result upon detection of GHB, because the solution takes on a yellow-green to green-blue tint which indicates the presence of GHB in said solution and/or of its sodium salt and/or of its potassium salt, whereas when GHB is not detected in the substance tested, the solution takes on a red to yellow hue.
A further advantage of a test manufactured according to the present invention is that it is possible to use it to detect the presence of GHB in substances containing other narcotics, particularly amphetamine and its derivatives, methamphetamine and its derivatives, ephedrine, alcaloids, opium, LSD, cocaine, benzyldiazepines, PCP and anabolic steroids.
A further advantage of detecting a narcotic, particularly GHB, according to the present invention is that the ethanol content of a drink does not significantly influence the test result.
The test for detecting narcotics, particularly GHB, manufactured according to the present invention is of a screening nature, facilitating the identification of this "club narcotic" particularly by way of the chromogenic reactions of GHB, its sodium or potassium salts, in their pure form as well as in aqueous and ethanolic dispersions and various drinks.
Furthermore, the test obtained according to the present invention is specific, characterised by high sensitivity and immune to interference by alcohols, sugars and chloride ions, including those found in alcoholic or soft drinks; which facilitates the detection of the presence of the narcotic through simple and easy application on site, wherein the test is performed over a time not exceeding 120 seconds.
The method of manufacturing the test according to the present invention as well as the method of detecting a narcotic, particularly GHB, according to the present invention is presented in example embodiments. Example I
The test is produced through mixing 0.03 parts by mass (pbm) of bromocresol green, 0.01 pbm methyl orange, 1.7 pbm glucose, 1.3 pbm diethylamine dihydrochloride, 35
pbm water and 185 pbm methanol, whereafter the solution is brought to pH 2.7 with
1.9 parts citric acid.
Example Il
The test is produced through mixing 0.03 parts by mass (pbm) of bromocresol green,
1.7 pbm glucose, 1.3 pbm diethylamine dihydrochloride, 35 pbm water and 185 pbm methanol, whereafter the solution is brought to pH 2.7 with 1.9 parts citric acid.
0.1 ml of the test solution prepared in this manner are transferred onto a glass plate and then dried at 50°C.
Example III
The test is produced through mixing 0.03 parts by mass (pbm) of bromocresol green,
0.01 pbm methyl orange, 1.7 pbm glucose, 1.3 pbm diethylamine dihydrochloride, 35 pbm water and 185 pbm methanol, whereafter the solution is brought to pH 2.6 with 2 parts citric acid.
0.1 ml of the test solution prepared in this manner are transferred onto a glass plate and then dried at 55°C.
Example IV
The test is produced through mixing 0.03 parts by mass (pbm) of bromocresol green,
0.01 pbm methyl orange, 1.7 pbm glucose, 1.5 pbm triethylamine trihydrochloride, 50 pbm water and 240 pbm methanol, whereafter the solution is brought to pH 3.0 with
1.6 parts citric acid.
0.1 ml of the test solution prepared in this manner are transferred onto a polyethylene-coated cellulose wafer and then dried at 25°C.
Example V
A 0.2 ml sample of beer are placed onto the test field, previously treated with 0.1 ml of test solution and dried.
If the sample of beer contains a narcotic, GHB, the test solution on the test field will assume a yellow-green hue demonstrating the presence of said narcotic in the sample of beer.
Example Vl
0.5 ml of the test solution are supplemented with 1 ml of beer.
If the sample of beer contains GHB or its salt the test solution assume a yellow-green hue demonstrating the presence of said narcotic in the sample of beer.
Claims
1. A method of manufacturing a test for the detection of narcotics, particularly gamma hydroxybutiric acid (GHB), based on the mixing and preferentially drying of components, characterised in that 2 to 5 parts by mass of bromocresol green are mixed with 100 to 180 parts by mass of amine salts, 150 to 210 parts by mass of sugar, 3000 to 6000 parts by mass of water and 18000 to 26000 parts by mass (pbm) of alcohol, where the solution obtained is brought to a pH of 1 to 4 using a non-volatile acid.
2. A method according to Claim 1 , characterised in that 1 to 2 pbm of methyl orange are added.
3. A method according to Claim 1 , characterised that a primary aliphatic amine salt is used.
4. A method according to Claim 1 , characterised in that the primary aliphatic amine salt used is diethylamine hydrochloride.
5. A method according to Claim 1 , characterised in that glucose is the sugar used.
6. A method according to Claim 1 , characterised in that methanol or ethanol are used.
7. A method according to Claim 1 , characterised in that the non-volatile acid used is citric acid.
8. A method according to Claim 1, characterised in that the 0.05 to 0.25 ml of the test solution are placed on any surface chemically inert with respect to the solution, and then the complex is dried at a temperature below 60°C.
9. A method of detecting narcotics, particularly GHB, characterised in that the test consisting of 0.05 to 0.25 ml of test solution is supplemented with minimum 0.1ml to maximum 0.5ml of the tested substance.
10. A method of detecting narcotics, particularly GHB, characterised in that 0.1 to 0.5 ml of the substance being tested are placed on the dried test.
11. A method of detecting narcotics, particularly GHB, according to Claim 10, characterised in that the surface on which the test solution is placed may be glass, porcelain or a plastic.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PLP.379257 | 2006-03-21 | ||
| PL379257A PL213310B1 (en) | 2006-03-21 | 2006-03-21 | Production method of a test for detection of drugs, especially gamma hydroxy butyric acid and detection method of a drug, especially gamma hydroxy butyric acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2007108710A1 true WO2007108710A1 (en) | 2007-09-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/PL2007/000013 WO2007108710A1 (en) | 2006-03-21 | 2007-03-19 | A method of manufacturing a test for the detection of narcotics, particularly gamma- hydroxybutiric acid (ghb), and a method of detecting their presence |
Country Status (2)
| Country | Link |
|---|---|
| PL (1) | PL213310B1 (en) |
| WO (1) | WO2007108710A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011153861A1 (en) * | 2010-06-08 | 2011-12-15 | 深圳市药品检验所 | Method for quickly detecting benzene diazepine doped in medicine and health care food |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3873269A (en) * | 1972-10-11 | 1975-03-25 | Merck Patent Gmbh | Indicator for the determination of urea |
| EP1211512A2 (en) * | 2000-11-30 | 2002-06-05 | Serim Research Corporation | Test strip for determining dialysate composition |
| WO2003021254A2 (en) * | 2001-09-04 | 2003-03-13 | Francisco Javier Guerra | Method for testing a beverage for illicit substances |
| US6617123B1 (en) * | 2000-06-29 | 2003-09-09 | Jack V. Smith | Method for detection of 4-hydroxybutyric acid and its precursor(s) in fluids |
| WO2005059541A1 (en) * | 2003-12-19 | 2005-06-30 | Bloomsbury Innovations Ltd. | Apparatus for detecting drugs in a beverage |
-
2006
- 2006-03-21 PL PL379257A patent/PL213310B1/en unknown
-
2007
- 2007-03-19 WO PCT/PL2007/000013 patent/WO2007108710A1/en active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3873269A (en) * | 1972-10-11 | 1975-03-25 | Merck Patent Gmbh | Indicator for the determination of urea |
| US6617123B1 (en) * | 2000-06-29 | 2003-09-09 | Jack V. Smith | Method for detection of 4-hydroxybutyric acid and its precursor(s) in fluids |
| EP1211512A2 (en) * | 2000-11-30 | 2002-06-05 | Serim Research Corporation | Test strip for determining dialysate composition |
| WO2003021254A2 (en) * | 2001-09-04 | 2003-03-13 | Francisco Javier Guerra | Method for testing a beverage for illicit substances |
| WO2005059541A1 (en) * | 2003-12-19 | 2005-06-30 | Bloomsbury Innovations Ltd. | Apparatus for detecting drugs in a beverage |
Non-Patent Citations (2)
| Title |
|---|
| BEYNON C M ET AL: "The ability of two commercially available quick test kits to detect drug-facilitated sexual assault drugs in beverages.", ADDICTION (ABINGDON, ENGLAND) OCT 2006, vol. 101, no. 10, October 2006 (2006-10-01), pages 1413 - 1420, XP002442739, ISSN: 0965-2140 * |
| MOFFAT A.C., OSSELTON M.D. & WIDDOP B.: "Clarke's Analysis of Drugs and Poisons in pharmaceuticals, body fluids and postmortem material. Third edition", 2004, PHARMACEUTICAL PRESS, XP002442743 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011153861A1 (en) * | 2010-06-08 | 2011-12-15 | 深圳市药品检验所 | Method for quickly detecting benzene diazepine doped in medicine and health care food |
Also Published As
| Publication number | Publication date |
|---|---|
| PL379257A1 (en) | 2007-10-01 |
| PL213310B1 (en) | 2013-02-28 |
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