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WO2005040215A3 - Ovomucoid promoters and mehtods of use - Google Patents

Ovomucoid promoters and mehtods of use Download PDF

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Publication number
WO2005040215A3
WO2005040215A3 PCT/US2004/016827 US2004016827W WO2005040215A3 WO 2005040215 A3 WO2005040215 A3 WO 2005040215A3 US 2004016827 W US2004016827 W US 2004016827W WO 2005040215 A3 WO2005040215 A3 WO 2005040215A3
Authority
WO
WIPO (PCT)
Prior art keywords
mehtods
ovomucoid promoters
ovomucoid
promoters
nucleic acid
Prior art date
Application number
PCT/US2004/016827
Other languages
French (fr)
Other versions
WO2005040215A2 (en
Inventor
Alex J Harvey
Markley C Leavitt
Youliang Wang
Original Assignee
Avigenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/496,731 external-priority patent/US7375258B2/en
Priority claimed from US10/790,455 external-priority patent/US20040210954A1/en
Application filed by Avigenics Inc filed Critical Avigenics Inc
Priority to EP04817319A priority Critical patent/EP1633781A2/en
Publication of WO2005040215A2 publication Critical patent/WO2005040215A2/en
Publication of WO2005040215A3 publication Critical patent/WO2005040215A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A01K2217/206—Animal model comprising tissue-specific expression system, e.g. tissue specific expression of transgene, of Cre recombinase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/30—Bird
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Husbandry (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention includes nucleic acid molecules comprising an artificial chromosome and an avian ovomucoid gene expression controlling region operably linked to the coding sequence of a useful polypeptide.
PCT/US2004/016827 2003-06-06 2004-05-28 Ovomucoid promoters and mehtods of use WO2005040215A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04817319A EP1633781A2 (en) 2003-06-06 2004-05-28 Ovomucoid promoters and methods of use

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US10/496,731 US7375258B2 (en) 2001-11-30 2002-12-02 Transgenic avians with an ovomucoid gene expression control region linked to a nucleotide sequence encoding a heterologous polypeptide
US47659603P 2003-06-06 2003-06-06
US60/476,596 2003-06-06
US49045203P 2003-07-28 2003-07-28
US60/490,452 2003-07-28
US50556203P 2003-09-24 2003-09-24
US60/505,562 2003-09-24
US50912203P 2003-10-06 2003-10-06
US60/509,122 2003-10-06
US53667704P 2004-01-15 2004-01-15
US60/536,677 2004-01-15
US10/790,455 US20040210954A1 (en) 2003-03-07 2004-03-01 Integrase mediated avian transgenesis
US10/790,455 2004-03-01
US10/496,731 2004-05-21

Publications (2)

Publication Number Publication Date
WO2005040215A2 WO2005040215A2 (en) 2005-05-06
WO2005040215A3 true WO2005040215A3 (en) 2005-06-30

Family

ID=34528484

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/016827 WO2005040215A2 (en) 2003-06-06 2004-05-28 Ovomucoid promoters and mehtods of use

Country Status (2)

Country Link
EP (1) EP1633781A2 (en)
WO (1) WO2005040215A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9150880B2 (en) 2008-09-25 2015-10-06 Proteovec Holding, L.L.C. Vectors for production of antibodies
US9150881B2 (en) 2009-04-09 2015-10-06 Proteovec Holding, L.L.C. Production of proteins using transposon-based vectors
US9157097B2 (en) 2008-09-25 2015-10-13 Proteovec Holding, L.L.C. Vectors for production of growth hormone

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7129390B2 (en) 1997-10-16 2006-10-31 Avigenics, Inc Poultry Derived Glycosylated Interferon Alpha 2b
US20040172667A1 (en) 2002-06-26 2004-09-02 Cooper Richard K. Administration of transposon-based vectors to reproductive organs
US8071364B2 (en) 2003-12-24 2011-12-06 Transgenrx, Inc. Gene therapy using transposon-based vectors
US8815242B2 (en) 2009-05-27 2014-08-26 Synageva Biopharma Corp. Avian derived antibodies
GB201420139D0 (en) 2014-11-12 2014-12-24 Ucl Business Plc Factor IX gene therapy
US10842885B2 (en) 2018-08-20 2020-11-24 Ucl Business Ltd Factor IX encoding nucleotides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999019472A1 (en) * 1997-10-16 1999-04-22 University Of Georgia Research Foundation, Inc. Vectors comprising a magnum-specific promoter for avian transgenesis
WO2003048364A2 (en) * 2001-11-30 2003-06-12 Avigenics, Inc. Ovomucoid promoter and methods of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999019472A1 (en) * 1997-10-16 1999-04-22 University Of Georgia Research Foundation, Inc. Vectors comprising a magnum-specific promoter for avian transgenesis
WO2003048364A2 (en) * 2001-11-30 2003-06-12 Avigenics, Inc. Ovomucoid promoter and methods of use

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] EBI; 2 July 1986 (1986-07-02), GERLINGER P. ET AL.; LAI EC ET AL.: "Chicken ovomucoid gene, 5' end region.", XP002315300, Database accession no. J00894 *
DATABASE EMBL [online] EBI; 30 November 2003 (2003-11-30), "Gallus gallus isolate No:26 ovomucoid gene, promoter region and partial cds.", XP002321164, Database accession no. AF453747 *
HARVEY AJ ET AL.: "Expression of exogenous protein in the egg white of transgenic chicken", NATURE BIOTECHNOLOGY, vol. 19, April 2002 (2002-04-01), pages 396 - 399, XP002973268 *
LAI EC ET AL.: "Heterogenous initiation sites for transcription of the chicken ovomucoid gene", J. OF SUPRAMOLECULAR STRUCUTRE AND CELLULAR BIOCHEMISTRY, no. 1157, 1981, pages 429, XP009043090 *
LAI EC ET AL.: "Molecular structure and flanking nucleotide sequences of the natural chicken ovomucoid gene", CELL, vol. 18, November 1979 (1979-11-01), pages 829 - 842, XP009045196 *
MINE Y. ET AL.: "Identification and fine mapping of IgG and IgE epitopes in ovomucoid", BIOCHEM BIOPHYS RES COMM, vol. 292, 2002, pages 1070 - 1074, XP002321109 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9150880B2 (en) 2008-09-25 2015-10-06 Proteovec Holding, L.L.C. Vectors for production of antibodies
US9157097B2 (en) 2008-09-25 2015-10-13 Proteovec Holding, L.L.C. Vectors for production of growth hormone
US9150881B2 (en) 2009-04-09 2015-10-06 Proteovec Holding, L.L.C. Production of proteins using transposon-based vectors

Also Published As

Publication number Publication date
EP1633781A2 (en) 2006-03-15
WO2005040215A2 (en) 2005-05-06

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