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WO2004030645A1 - Use of a pear must extract as active principle in a cosmetic and/or pharmaceutical composition - Google Patents

Use of a pear must extract as active principle in a cosmetic and/or pharmaceutical composition Download PDF

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Publication number
WO2004030645A1
WO2004030645A1 PCT/FR2003/002876 FR0302876W WO2004030645A1 WO 2004030645 A1 WO2004030645 A1 WO 2004030645A1 FR 0302876 W FR0302876 W FR 0302876W WO 2004030645 A1 WO2004030645 A1 WO 2004030645A1
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WO
WIPO (PCT)
Prior art keywords
extract
composition
skin
pear
cosmetic
Prior art date
Application number
PCT/FR2003/002876
Other languages
French (fr)
Inventor
Claude Dal Farra
Nouha Domloge
Dominique Peyronel
Original Assignee
Societe D'extraction Des Primcipes Actifs (Vincience)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe D'extraction Des Primcipes Actifs (Vincience) filed Critical Societe D'extraction Des Primcipes Actifs (Vincience)
Priority to EP03776947A priority Critical patent/EP1553919A1/en
Priority to AU2003286206A priority patent/AU2003286206A1/en
Publication of WO2004030645A1 publication Critical patent/WO2004030645A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the invention relates to the field of cosmetics and pharmaceuticals, in particular the field of dermatology.
  • the main object of the present invention is the use of an effective amount of at least one extract of pear marc as active ingredient, in or for the preparation of a cosmetic and / or dermatological and / or pharmaceutical composition.
  • the skin aging process is due to a gradual change in the structure and functions of the skin. These changes take place in the dermis and epidermis, they are caused, in part, by cell senescence.
  • the main clinical signs are manifested, in particular, by the formation of wrinkles and fine lines, by the loss of elasticity of the skin but also by skin which becomes thinner and more sensitive to attack.
  • Many products offer to fight against the manifestations of this aging and, in particular, to reduce wrinkles; but to date, few products have really significant results. It is therefore observed that there remains the need for a new product having an effective action on the manifestations of skin aging.
  • One of the objectives of the present invention is therefore to be able to have a new product having an effective effect in order to combat the skin signs of aging.
  • the pear is the fruit of the pear tree (Pirus communis), tree of the Rosaceae family, of the genus Pirus. It has been known since Antiquity and it is cultivated in all warm temperate climates. Pears come in many sizes, colors and flavors. There are several varieties: summer pears (Williams and Guyot varieties), autumn pears (buttery Hardy, Conf45, Comice) and winter pears (Passe-crassane). The pear has seeds, seeds, small, poor in albumen.
  • the primary object of the invention is the use of an effective amount of at least one pear marc extract as active ingredient in or for the preparation of a cosmetic and / or dermatological and / or pharmaceutical composition.
  • the active principle can be defined as being a molecule or a set of molecules capable of bringing modifications or modulations to the functioning of a biological system.
  • pear marc designates the residue of the fruits (pears) that have been pressed to extract, in particular, the juice.
  • extract relates to any isolated substance obtained from the raw material that constitutes pear marc.
  • an extract of pear marc is understood to mean a crude mixture of the coarsely reduced parts of pears, in order to extract the juice from it, and of the extraction solvent, but also preparations of active principles which have were dissolved during extraction.
  • the extract of pear marc must be understood as an extract of marc from at least one fruit from a plant belonging to the genus Pirus.
  • the extract can be prepared from the marc of the fruits of at least any one of the many varieties and species belonging to the genus Pirus.
  • the extract of "pear marc” is prepared from the fruits of at least one plant originating from the species Pirus communis.
  • the pear marc consists, for the most part, of skins and pear seeds. It is thus possible to define the pear marc extract, according to the invention, as being an extract of skins and pear seeds.
  • the pear marc that is to say the pear residue, consists essentially of pear seeds.
  • the pear marc extract according to the invention is an extract of pear seed.
  • the pear marc extract contains compounds such as phytosteroids, phytosterols or ursolic acid. Indeed, the presence of these compounds contributes to the exceptional qualities of the extract according to the invention. These compounds play an important role in the skin, they have, among other things, regenerating, antioxidant, firming or even soothing properties.
  • Phytosteroids refer to steroids found in plants. They are polycyclic compounds of the terpene family.
  • Phytosterols are steroids with an alcohol function. They have a chemical structure close to that of cholesterol, which gives them similar properties. They play, in particular, a major role in the stabilization of the lipid membrane structures thus strengthening the skin barrier and ensuring excellent protection of the skin against environmental stress. Phytosterols also have anti-inflammatory, antioxidant, cytoprotective and photoprotective properties. As an indication, phytosterols include, for example, stigmasterols, ⁇ and ⁇ sitosterols, campesterols, etc.
  • the extract according to the invention contains between 5 and 30% phytosterol.
  • the pear marc extract contains between 10 and 40% of ursolic acid.
  • Ursolic acid a substance of a triterpenoid nature, is a compound well known for its beneficial activity in the skin, in particular by its action on the synthesis of fibers of the connective tissue, as well as for its anti-inflammatory activity (Price and al., 1987; Mahato et al., 1988).
  • the marc extract according to the invention also contains tocopherols and tocotrienols which have an important anti-oxidation role; they protect polyunsaturated fatty acids and membrane proteins against oxidation by free radicals.
  • the extract also contains waxes of essential fatty acids which improve the hydration and suppleness of the skin.
  • the invention also relates to the use of an effective amount of at least one pear marc extract, as defined above, in or for the preparation of a composition; the extract or the composition being intended to treat curatively and / or preventively the cutaneous manifestations of aging.
  • cutaneous manifestations of aging means any modification of the external appearance of the skin due to aging, for example, wrinkles and fine lines, withered skin, soft skin, thinned skin, lack of elasticity and / or skin tone, dull and dull skin but also all internal skin modifications which do not systematically result in a modified external appearance such as, for example, all internal degradations of the skin following exposure to ultra- purples.
  • the extract, or the composition therefore have a positive effect on all the cutaneous manifestations of aging, they will thus be intended, in particular, to reduce wrinkles and / or fine lines and / or to smooth the skin.
  • This extract will, in the same way, help fight against sagging and loss of skin tone.
  • the skin After applying the pear extract according to the invention, the skin will be smoother, firmer and better hydrated. The skin will appear younger.
  • This extract makes it possible to avoid the phenomena of withered skin, soft skin or even thinned skin. It makes it possible to prevent the lack of elasticity and / or tone of the skin, but also to fight against the internal degradations of the skin consecutive to an exposure to ultraviolet radiation.
  • the extract of pear marc also has a positive effect on the extracellular matrix. Indeed, it has been demonstrated that the extract according to the invention increases the synthesis of proteins of the extracellular matrix, and in particular, that it increases the synthesis of collagen.
  • the subject of the invention is also the use of an effective amount of at least one pear extract in or for the preparation of a composition; the extract or the composition being intended to hydrate the skin and / or to protect the skin against all types of external aggressions.
  • a specialist in the extraction and purification of plants can be used in order to prepare the pear marc extract according to the invention.
  • the pressing residue i.e. pear marc
  • the pressing residue is treated in order to remove the residual components from the pulp, these components are then made soluble in water by the addition of a chemical agent and / or a mixture of one or more enzymes of the pectinase, cellulase or protease type.
  • This operation is carried out at a temperature between 10 and 80 ° C.
  • the medium is washed with water, for example, then a main residue composed mainly of seeds (seeds) and skins is recovered by filtration or centrifugation. This residue is subsequently washed and dried.
  • solubilizers of the fruit flesh can be added before the pressing operation.
  • the residue obtained after pressing can be dried directly.
  • the residues are ground, then extracted with an organic solvent suitable for cosmetics, preferably an alcohol (ethanol, isopropanol) or a chlorinated solvent (chloroform, dichloromethane). Filtration and sterilization steps can be carried out thereafter.
  • this extract can be redissolved in order to carry out a crystallization step with the aim of eliminating neutral lipids and / or enriching it with sterolic compounds and / or terpene acid.
  • This step can advantageously be carried out before the total evaporation of the extraction solvent (ethanol or chloroform) if the latter authorizes it.
  • the extract obtained can then contain between 5 and 90% of phytosterols and between 10 and 90% of ursolic acid.
  • the evaporated extract is subsequently redissolved, or dispersed, in a solvent suitable for cosmetic use, preferably in a lipid solvent such as a fatty alcohol such as hydroxyldecanol, at a concentration of 3%. .
  • the subject of the invention is a composition containing, as active principle, in a cosmetically or pharmaceutically acceptable medium, at least one extract of pear marc as defined above.
  • the composition according to the invention can be a cosmetic and / or dermatological and / or pharmaceutical composition.
  • the composition is a cosmetic composition, because it is intended to improve the appearance and the general cutaneous performance of the individual who uses it.
  • the composition according to the invention is preferably a cosmetic and / or dermatological composition suitable for administration by the topical skin route comprising a cosmetically or dermatologically acceptable medium.
  • the invention is intended for mammals in general and more particularly for human beings.
  • the amount of extract usable according to the invention is, of course, a function of the desired effect and can therefore vary to a large extent.
  • the abovementioned pear marc extract can be used, in the compositions of the invention, in an amount representing between 0.00001% and 20% approximately, of the total weight of the composition, and preferably , in an amount representing between 0.0001% and 5%, approximately, relative to the total weight of the final composition.
  • the pear marc extract according to the invention can be used in pure form or in solution in one or more solvents suitable for cosmetics or pharmaceuticals.
  • the above-mentioned extract is dissolved beforehand or dispersed in one or more cosmetically or pharmaceutically acceptable solvents such as ethanol, propanol or isopropanol, propylene glycol, butylene glycol, dipropylene glycol , ethoxylated or propoxylated diglycols or any mixture of these solvents.
  • the pear marc extract is dissolved beforehand in a cosmetic or pharmaceutical carrier such as liposomes or adsorbed on powdery organic polymers, mineral supports such as talcs and bentonites, and more generally solubilized in, or attached to, any cosmetically or pharmaceutically acceptable carrier.
  • a cosmetic or pharmaceutical carrier such as liposomes or adsorbed on powdery organic polymers, mineral supports such as talcs and bentonites, and more generally solubilized in, or attached to, any cosmetically or pharmaceutically acceptable carrier.
  • the composition according to the invention can be ingested, injected or applied to the skin (on any cutaneous zone of the body), the hair, the nails or the mucous membranes.
  • the composition according to the invention can be in all the galenical forms normally used.
  • the compositions according to the present invention will be presented in a galenical form suitable for administration by the topical cutaneous route. They cover all cosmetic and dermatological forms. These compositions must therefore contain a cosmetically acceptable medium, that is to say compatible with the skin, hair or hair.
  • compositions can in particular be in the form of an aqueous, hydroalcoholic or oily solution; an oil-in-water, water-in-oil or multiple emulsion; they can also be in the form of creams, suspensions or even powders, suitable for application to the skin, mucous membranes, lips and / or hair.
  • compositions can be more or less fluid and have the appearance of a cream, a lotion, a milk, a serum, an ointment, a shampoo, a gel, a paste or foam. They can also be in solid form, such as a stick, or be applied to the skin in the form of an aerosol. They can be used as a care product and / or as a make-up product for the skin.
  • the composition according to the invention can be in the form of an aqueous, oily lotion or in the form of serum.
  • the composition can be in the form of drops and for ingestion, it can be in the form of capsules, granules, syrups or tablets.
  • compositions also include any additive commonly used in the intended field of application as well as the adjuvants necessary for their formulation, such as solvents, thickeners, diluents, antioxidants, dyes, sunscreens, self-tanning agents, pigments, fillers, preservatives, perfumes, odor absorbers, cosmetic or pharmaceutical active ingredients, essential oils, vitamins, essential fatty acids, surfactants, film-forming polymers, etc. ....
  • these adjuvants are chosen so as not to harm the desired advantageous properties of the composition according to the invention.
  • These adjuvants can, for example, correspond from 0.01 to 20% of the total weight of the composition.
  • the fatty phase may represent from 5 to 80% by weight and preferably from 5 to 50% by weight relative to the total weight of the composition.
  • the emulsifiers and co-emulsifiers used in the composition will be chosen from those conventionally used in the field under consideration. For example, they can be used in a proportion ranging from 0.3 to 30% by weight, relative to the total weight of the composition.
  • those skilled in the art will take care to choose any additional compounds, active or non-active, and / or their quantities, so that the advantageous properties of the mixture are not, or not substantially, altered by the addition considered.
  • compositions according to the invention find application in particular as a cosmetic or pharmaceutical composition for the skin, mucous membranes and / or semi-mucous membranes, but also as a cosmetic composition for the hair and / or body hair.
  • compositions which are the subject of the invention find their application in a large number of treatments, in particular cosmetic or dermatological treatments, and they can constitute a cosmetic composition, in particular for the treatment, protection, care, make-up removal and / or cleaning of the skin, lips and / or hair, and / or for making up the skin, lips, eyelashes and / or body.
  • composition according to the invention may also consist of solid preparations also comprising soaps or cleaning bars.
  • the composition can also be packaged in the form of an aerosol composition also comprising a propellant under pressure.
  • composition can also be for oral use, for example a toothpaste paste.
  • composition of the invention can also be a cosmetic composition intended for oral administration.
  • the composition according to the invention can be in any suitable form, particularly in the form of an oral solution, a syrup, a tablet, a dragee, a capsule or still a food or nutritional supplement.
  • the invention also relates to a cosmetic process intended to treat the cutaneous manifestations of aging, consisting in applying, to the skin, a composition, as defined above, comprising, at least, an extract of pear marc.
  • the invention also relates to a cosmetic process intended to reduce wrinkles and / or fine lines on the skin, and / or to smooth the skin, consisting in applying the composition as defined above to the skin.
  • the invention also relates to a cosmetic treatment method intended to fight against withered skin and / or to fight against thinned skin and / or to fight against soft skin and / or to fight against lack of elasticity and / or skin tone, consisting in applying, to the skin, a composition as defined above comprising at least one extract of pear marc.
  • the invention also relates to a cosmetic treatment method intended to hydrate the skin and / or protect the skin against all types of external aggression, consisting in applying to the skin a composition as defined above comprising at least one marc extract. Pear.
  • the cosmetic treatment process of the invention can be implemented in particular by applying the cosmetic compositions as defined above, according to the usual technique for using these compositions, for example: application of creams, gels, serums , lotions, milks, shampoos or sunscreen compositions, on the skin or on the hair, or else application of toothpaste on the gums.
  • Example 1 Preparation of a pear marc extract.
  • a kilogram of pear is sorted, washed vigorously with clean water and dried. These fruits are then pressed in a belt or belt press. We then recover between 100 and 300 g of residue from these fruits, called marc or drake.
  • the pressing is progressive in order to avoid obstruction of the juice flow channels, its intensity depends on the maturity of the fruit.
  • the marc is then suspended in 2 to 10 times its volume of water, in a tank with constant stirring.
  • the medium is kept, with stirring, at a temperature between
  • the medium is transferred to a 0.2 to 3 mm mesh sieve (or to a wringer with a similar mesh or, again, centrifuged) in order to separate the soluble elements present in the residue.
  • This residue is then washed until an insoluble residue composed largely of seeds and fruit skins is obtained.
  • This residue is then dried in an oven, and crushed using an appropriate plant grinder, preferably in a hammer mill.
  • the powder is then extracted using an organic solvent (or a mixture of solvents).
  • an organic solvent or a mixture of solvents.
  • the solvent used will be an alcohol (ethanol or isopropanol).
  • This extraction is carried out in a stirred extractor or, in a conventional manner, in a plant extractor, by circulation of the solvent.
  • the temperature of the extraction varies from room temperature to the reflux temperature of the solvent.
  • the extraction solvent is then filtered and then evaporated.
  • a waxy extract of green color is then obtained which can be used as it is, titrating between 5 and 30% of phytosterol and between 10 and 30% of ursolic acid. Filtration and sterilization steps can be carried out thereafter.
  • the extract is subsequently dispersed in a solvent suitable for cosmetic use, such as hydroxyldecanol, at a concentration of 3%.
  • a solvent suitable for cosmetic use such as hydroxyldecanol
  • Example 2 Effects of the extract of Example 1 on the skin and on the manifestations of skin aging
  • Example 1 A clinical study was carried out, double blind, on a group of twenty volunteers, in order to highlight the effect of Example 1 on the improvement of the skin relief and, more particularly, its action on the condition of wrinkles.
  • the volunteers applied the extract of Example 1, formulated at 2.5% in a cream, to the area around the eye, on one side of the face; the area around the eye on the other side of the face being used for the application of the placebo.
  • the volunteers thus applied the product, dosed at 2 mg / cm 2 , twice a day, for 8 weeks.
  • the evolution of the skin relief and the condition of wrinkles was evaluated after clinical observation (by the use of photos), as well as by an analysis of the surface of the skin using replicas of silicone.
  • the study included nine follow-up visits: one visit before the start of treatment (T0), and one visit every week for 8 weeks. Photos were taken at T0 and T8 using a video camera (COHU High performance CDD camera) and negative impressions of silicone on the skin surface were made, using different markers, at the area around the eye. The photos of the prints were taken under oblique light, using the camera described above.
  • the skin relief measurement was obtained by image analysis, after using a specific software (Quantirides, Monaderm) allowing to calculate the standard parameters of wrinkles such as the number, the complete surface (in mm 2 ) and the length total (in mm).
  • Rejection region as far as the difference is predictable, the rejection region will be unilateral. The level of significance is at 5%.
  • compositions were obtained by simple mixing of the various components.
  • the quantities indicated are given as a percentage by weight.
  • Aqueous phase Aqueous phase :

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Abstract

The invention concerns the field of cosmetics and pharmaceutics, in particular the field of dermatology. The invention relates to the use of an efficient amount of at least one pear must extract as active principle, in or for preparing a cosmetic and/or dermatological and/or pharmaceutical composition.

Description

Utilisation d'un extrait de marc de poire comme principe actif dans une composition cosmétique et/ou pharmaceutique. Use of a pear marc extract as active ingredient in a cosmetic and / or pharmaceutical composition.
L'invention concerne le domaine de la cosmétique et de la pharmaceutique, notamment le domaine de la dermatologie. La présente invention a pour principal objet l'utilisation d'une quantité efficace d'au moins un extrait de marc de poire comme principe actif, dans ou pour la préparation d'une composition cosmétique et/ou dermatologique et/ou pharmaceutique.The invention relates to the field of cosmetics and pharmaceuticals, in particular the field of dermatology. The main object of the present invention is the use of an effective amount of at least one extract of pear marc as active ingredient, in or for the preparation of a cosmetic and / or dermatological and / or pharmaceutical composition.
La lutte contre les phénomènes de vieillissement de l'homme mobilise aujourd'hui l'activité de plus en plus de chercheurs. C'est particulièrement le cas dans le domaine de la cosmétique où de grands moyens sont mis en œuvre pour lutter ou, tout au moins, pour ralentir l'apparition des effets inesthétiques du vieillissement. Le processus de vieillissement cutané est dû à une modification progressive de la structure et des fonctions cutanées. Ces modifications ont lieu dans le derme et Fépiderme, elles sont causées, en partie, par la sénescence des cellules. Les principaux signes cliniques se manifestent, notamment, par la formation de rides et de ridules, par la perte d'élasticité de la peau mais aussi par une peau qui devient plus fine et plus sensible aux agressions. De nombreux produits proposent de lutter contre les manifestations de ce vieillissement et, en particulier, de diminuer les rides ; mais à ce jour, peu de produits ont des résultats qui sont réellement significatifs. On constate donc que subsiste le besoin d'un produit nouveau ayant une action efficace sur les manifestations du vieillissement cutané.The fight against the phenomena of aging of man mobilizes today the activity of more and more researchers. This is particularly the case in the field of cosmetics where great resources are used to combat or, at least, to slow down the appearance of the unsightly effects of aging. The skin aging process is due to a gradual change in the structure and functions of the skin. These changes take place in the dermis and epidermis, they are caused, in part, by cell senescence. The main clinical signs are manifested, in particular, by the formation of wrinkles and fine lines, by the loss of elasticity of the skin but also by skin which becomes thinner and more sensitive to attack. Many products offer to fight against the manifestations of this aging and, in particular, to reduce wrinkles; but to date, few products have really significant results. It is therefore observed that there remains the need for a new product having an effective action on the manifestations of skin aging.
Un des objectifs de la présente invention est donc de pouvoir disposer d'un produit nouveau ayant un effet efficace afin de lutter contre les signes cutanés du vieillissement.One of the objectives of the present invention is therefore to be able to have a new product having an effective effect in order to combat the skin signs of aging.
La demanderesse s'est ainsi orientée vers des produits d'origine naturelle, en particulier, des produits d'origine végétale, dont on reconnaît, aujourd'hui, les nombreuses vertus. Elle a ainsi découvert, de manière surprenante et inattendue, qu'un extrait de certaines parties de la poire, et plus précisément qu'un extrait de marc de poire, possède une action particulièrement efficace au niveau de la peau, permettant de lutter, notamment, contre les manifestations du vieillissement cutané. A la connaissance de la demanderesse, il n'a jamais été décrit, dans l'art antérieur, l'utilisation d'un extrait de marc de poire en cosmétique et/ou en dermatologie et/ou en pharmaceutique.The applicant has thus turned to products of natural origin, in particular, products of plant origin, the many virtues of which are recognized today. She thus discovered, surprisingly and unexpectedly, that an extract of certain parts of the pear, and more precisely that an extract of pear marc, has a particularly effective action on the skin, making it possible to fight, in particular , against the manifestations of skin aging. To the knowledge of the applicant, it has never been described, in the prior art, the use of an extract of pear marc in cosmetics and / or in dermatology and / or in pharmaceuticals.
La poire est le fruit du poirier (Pirus communis), arbre de la famille des rosacées, du genre Pirus. Il est connu depuis l'Antiquité et il est cultivé sous tous les climats tempérés chauds. Les poires sont de taille, de couleur et de saveur très diverses. On en distingue plusieurs variétés : les poires d'été (les variétés Williams et Guyot), les poires d'automne (beurré Hardy, Conférence, Comice) et les poires d'hiver (Passe-crassane). La poire possède des graines, les pépins, de petite taille, pauvres en albumen.The pear is the fruit of the pear tree (Pirus communis), tree of the Rosaceae family, of the genus Pirus. It has been known since Antiquity and it is cultivated in all warm temperate climates. Pears come in many sizes, colors and flavors. There are several varieties: summer pears (Williams and Guyot varieties), autumn pears (buttery Hardy, Conférence, Comice) and winter pears (Passe-crassane). The pear has seeds, seeds, small, poor in albumen.
L'invention a pour objet premier l'utilisation d'une quantité efficace d'au moins un extrait de marc de poire comme principe actif dans ou pour la préparation d'une composition cosmétique et/ou dermatologique et/ou pharmaceutique.The primary object of the invention is the use of an effective amount of at least one pear marc extract as active ingredient in or for the preparation of a cosmetic and / or dermatological and / or pharmaceutical composition.
Le principe actif peut se définir comme étant une molécule ou un ensemble de molécule susceptible d'apporter des modifications ou des modulations au fonctionnement d'un système biologique.The active principle can be defined as being a molecule or a set of molecules capable of bringing modifications or modulations to the functioning of a biological system.
L'expression "marc de poire" désigne le résidu des fruits (les poires) que l'on a pressés pour en extraire, notamment, le jus. Le terme "extrait" est relatif à toute substance isolée, obtenue à partir de la matière première que constitue le marc de poire. Par exemple, on entend par l'expression "un extrait de marc de poire", un mélange brut des parties de poires grossièrement réduites, pour en extraire le jus, et du solvant d'extraction, mais aussi des préparations de principes actifs qui ont été solubilisées lors de l'extraction. L'extrait de marc de poire doit s'entendre comme un extrait de marc d'au moins un fruit issu d'un végétal appartenant au genre Pirus. Bien entendu l'extrait peut être préparé à partir du marc des fruits d'au moins l'une quelconque des nombreuses variétés et espèces appartenant au genre Pirus. Préférentiellement, l'extrait «de marc de poire est préparé à partir des fruits d'au moins un végétal provenant de l'espèce Pirus communis. Selon un mode de réalisation préféré de l'invention, le marc de poire est constitué, en majorité, de peaux et de pépins de poire. On peut ainsi définir l'extrait de marc de poire, selon l'invention, comme étant un extrait de peaux et de pépins de poire. Par ailleurs, selon un autre mode de réalisation préféré de l'invention, le marc de poire, c'est-à-dire le résidu de poire, est constitué essentiellement de pépins de poire. Ainsi, de manière avantageuse, l'extrait de marc de poire, selon l'invention, est un extrait de pépin de poire. Par ailleurs, une des caractéristiques essentielles de l'invention est que l'extrait de marc de poire contient des composés tels que des phytostéroïdes, des phytostérols ou de l'acide ursolique. En effet, la présence de ces composés contribue aux qualités exceptionnelles de l'extrait selon l'invention. Ces composés jouent un rôle important au niveau de la peau, ils ont, entre autres, des propriétés régénérantes, anti-oxydantes, raffermissantes ou encore apaisantes.The expression "pear marc" designates the residue of the fruits (pears) that have been pressed to extract, in particular, the juice. The term "extract" relates to any isolated substance obtained from the raw material that constitutes pear marc. For example, the expression “an extract of pear marc” is understood to mean a crude mixture of the coarsely reduced parts of pears, in order to extract the juice from it, and of the extraction solvent, but also preparations of active principles which have were dissolved during extraction. The extract of pear marc must be understood as an extract of marc from at least one fruit from a plant belonging to the genus Pirus. Of course the extract can be prepared from the marc of the fruits of at least any one of the many varieties and species belonging to the genus Pirus. Preferably, the extract of "pear marc" is prepared from the fruits of at least one plant originating from the species Pirus communis. According to a preferred embodiment of the invention, the pear marc consists, for the most part, of skins and pear seeds. It is thus possible to define the pear marc extract, according to the invention, as being an extract of skins and pear seeds. Furthermore, according to another preferred embodiment of the invention, the pear marc, that is to say the pear residue, consists essentially of pear seeds. Thus, advantageously, the pear marc extract according to the invention is an extract of pear seed. Furthermore, one of the essential characteristics of the invention is that the pear marc extract contains compounds such as phytosteroids, phytosterols or ursolic acid. Indeed, the presence of these compounds contributes to the exceptional qualities of the extract according to the invention. These compounds play an important role in the skin, they have, among other things, regenerating, antioxidant, firming or even soothing properties.
Les phytostéroïdes désignent des stéroïdes présents dans les plantes. Ce sont des composés polycycliques de la famille des terpènes.Phytosteroids refer to steroids found in plants. They are polycyclic compounds of the terpene family.
Les phytostérols sont des stéroïdes possédant une fonction alcool. Ils ont une structure chimique proche de celle du cholestérol qui leur confère ainsi des propriétés similaires. Ils jouent, notamment, un rôle majeur dans la stabilisation des structures lipidiques membranaires renforçant ainsi la barrière cutanée et assurant une excellente protection de la peau contre le stress environnemental. Les phytostérols possèdent, en outre, des propriétés anti-inflammatoires, anti-oxydantes, cytoprotectrices et photoprotectrices. A titre indicatif, les phytostérols comprennent, par exemple, les stigmastérols, les α et β sitostérols, les campestérols... Avantageusement, l'extrait selon l'invention contient entre 5 et 30 % de phytostérol.Phytosterols are steroids with an alcohol function. They have a chemical structure close to that of cholesterol, which gives them similar properties. They play, in particular, a major role in the stabilization of the lipid membrane structures thus strengthening the skin barrier and ensuring excellent protection of the skin against environmental stress. Phytosterols also have anti-inflammatory, antioxidant, cytoprotective and photoprotective properties. As an indication, phytosterols include, for example, stigmasterols, α and β sitosterols, campesterols, etc. Advantageously, the extract according to the invention contains between 5 and 30% phytosterol.
Par ailleurs, une des autres caractéristiques essentielles de l'invention, est que l'extrait de marc de poire contient entre 10 et 40 % d'acide ursolique. L'acide ursolique, une substance de nature triterpénoïde, est un composé bien connu pour son activité bénéfique au niveau de la peau, notamment par son action sur la synthèse de fibres du tissu conjonctif, ainsi que pour son activité anti-inflammatoire (Price et al., 1987 ; Mahato et al., 1988).Furthermore, one of the other essential characteristics of the invention is that the pear marc extract contains between 10 and 40% of ursolic acid. Ursolic acid, a substance of a triterpenoid nature, is a compound well known for its beneficial activity in the skin, in particular by its action on the synthesis of fibers of the connective tissue, as well as for its anti-inflammatory activity (Price and al., 1987; Mahato et al., 1988).
L'extrait de marc selon l'invention contient aussi des tocophérols et des tocotriénols qui ont un rôle important d'anti-oxydation ; ils protègent les acides gras poly-insaturés et les protéines membranaires contre l'oxydation par les radicaux libres. L'extrait contient, de plus, des cires d'acides gras essentiels qui améliorent l'hydratation et la souplesse de la peau. L'invention a, en outre, pour objet l'utilisation d'une quantité efficace d'au moins un extrait de marc de poire, tel que défini précédemment, dans ou pour la préparation d'une composition ; l'extrait ou la composition étant destinés à traiter de manière curative et/ou préventive les manifestations cutanées du vieillissement. Par manifestations cutanées du vieillissement on entend toutes modifications de l'aspect extérieur de la peau dues au vieillissement comme, par exemple, les rides et ridules, la peau flétrie, la peau molle, la peau amincie, le manque d'élasticité et/ou de tonus de la peau, la peau terne et sans éclat mais également toutes modifications internes de la peau qui ne se traduisent pas systématiquement par un aspect extérieur modifié comme, par exemple, toutes dégradations internes de la peau consécutives à une exposition aux rayonnements ultra- violets.The marc extract according to the invention also contains tocopherols and tocotrienols which have an important anti-oxidation role; they protect polyunsaturated fatty acids and membrane proteins against oxidation by free radicals. The extract also contains waxes of essential fatty acids which improve the hydration and suppleness of the skin. The invention also relates to the use of an effective amount of at least one pear marc extract, as defined above, in or for the preparation of a composition; the extract or the composition being intended to treat curatively and / or preventively the cutaneous manifestations of aging. The expression “cutaneous manifestations of aging” means any modification of the external appearance of the skin due to aging, for example, wrinkles and fine lines, withered skin, soft skin, thinned skin, lack of elasticity and / or skin tone, dull and dull skin but also all internal skin modifications which do not systematically result in a modified external appearance such as, for example, all internal degradations of the skin following exposure to ultra- purples.
L'extrait, ou la composition, ont donc un effet positif sur toutes les manifestations cutanées du vieillissement, ils vont ainsi être destinés, notamment, à diminuer les rides et/ou les ridules et/ou à lisser la peau. Cet extrait va, de la même manière, permettre de lutter contre le relâchement et la perte de tonicité de la peau. Après application de l'extrait de poire selon l'invention, la peau sera plus lisse, plus ferme et mieux hydratée. La peau apparaîtra ainsi plus jeune.The extract, or the composition, therefore have a positive effect on all the cutaneous manifestations of aging, they will thus be intended, in particular, to reduce wrinkles and / or fine lines and / or to smooth the skin. This extract will, in the same way, help fight against sagging and loss of skin tone. After applying the pear extract according to the invention, the skin will be smoother, firmer and better hydrated. The skin will appear younger.
Cet extrait permet d'éviter les phénomènes de peau flétrie, de peau molle ou encore de peau amincie. Il permet de prévenir le manque d'élasticité et/ou de tonus de la peau, mais aussi de lutter contre les dégradations internes de la peau consécutives à une exposition aux rayonnements ultra-violets.This extract makes it possible to avoid the phenomena of withered skin, soft skin or even thinned skin. It makes it possible to prevent the lack of elasticity and / or tone of the skin, but also to fight against the internal degradations of the skin consecutive to an exposure to ultraviolet radiation.
L'extrait de marc de poire a, par ailleurs, un effet positif au niveau de la matrice extracellulaire. En effet, il a été démontré que l'extrait selon l'invention augmente la synthèse des protéines de la matrice extra-cellulaire, et notamment, qu'il augmente la synthèse du collagène.The extract of pear marc also has a positive effect on the extracellular matrix. Indeed, it has been demonstrated that the extract according to the invention increases the synthesis of proteins of the extracellular matrix, and in particular, that it increases the synthesis of collagen.
Par ailleurs, l'invention a également comme objet l'utilisation d'une quantité efficace d'au moins un extrait de poire dans ou pour la préparation d'une composition ; l'extrait ou la composition étant destinés à hydrater la peau et/ou à protéger la peau contre tous types d'agressions extérieures.Furthermore, the subject of the invention is also the use of an effective amount of at least one pear extract in or for the preparation of a composition; the extract or the composition being intended to hydrate the skin and / or to protect the skin against all types of external aggressions.
Toute méthode connue de l'homme du métier, un spécialiste de l'extraction et de la purification des végétaux, peut être utilisée afin de préparer l'extrait de marc de poire selon l'invention. Afin d'obtenir l'extrait de marc de poire selon l'invention, on peut par exemple, réaliser, dans une première étape, le pressage des poires dans une presse à tapis ou à bande, quels que soient les états de maturation de celles-ci. Le résidu de pressage (c'est-à- dire le marc de poire) est ensuite récupéré. Dans une deuxième étape, le résidu de pressage est traité afin d'éliminer les composants résiduels de la pulpe, ces composants sont ensuite rendus solubles à l'eau par l'adjonction d'un agent chimique et/ou d'un mélange d'une ou de plusieurs enzymes de type pectinase, cellulase ou protéase. Cette opération est réalisée à une température comprise entre 10 et 80°C. Après macération, le milieu est lavé à l'eau, par exemple, puis un résidu principal composé en majeure partie de graines (pépins) et de peaux est récupéré par filtration ou centrifugation. Ce résidu est, par la suite, lavé et séché.Any method known to a person skilled in the art, a specialist in the extraction and purification of plants, can be used in order to prepare the pear marc extract according to the invention. In order to obtain the pear marc extract according to the invention, it is possible, for example, to carry out, in a first step, the pressing of the pears in a belt or belt press, whatever the maturation states of those -this. The pressing residue (i.e. pear marc) is then recovered. In a second step, the pressing residue is treated in order to remove the residual components from the pulp, these components are then made soluble in water by the addition of a chemical agent and / or a mixture of one or more enzymes of the pectinase, cellulase or protease type. This operation is carried out at a temperature between 10 and 80 ° C. After maceration, the medium is washed with water, for example, then a main residue composed mainly of seeds (seeds) and skins is recovered by filtration or centrifugation. This residue is subsequently washed and dried.
Dans une variante de ce procédé, des agents solubilisants de la chair des fruits peuvent être ajoutés avant l'opération de pressage. Dans une autre variante de ce procédé, le résidu obtenu après pressage peut être séché directement.In a variant of this process, solubilizers of the fruit flesh can be added before the pressing operation. In another variant of this process, the residue obtained after pressing can be dried directly.
Dans une dernière étape, les résidus sont broyés, puis extraits par un solvant organique adapté à la cosmétique, préférentiellement un alcool (éthanol, isopropanol) ou un solvant chloré (chloroforme, dichlorométhane). Des étapes de filtration et de stérilisation peuvent être effectuées par la suite. Selon une variante du procédé, cet extrait peut être remis en solution afin de réaliser une étape de cristallisation dans le but d'éliminer les lipides neutres et/ou de l'enrichir en composés stéroliques et/ou en acide terpénique. Cette étape peut, avantageusement, être réalisée avant l'évaporation totale du solvant d'extraction (éthanol ou chloroforme) si celui-ci l'autorise. L'extrait obtenu peut alors contenir entre 5 et 90 % de phytostérols et entre 10 et 90 % d'acide ursolique.In a final step, the residues are ground, then extracted with an organic solvent suitable for cosmetics, preferably an alcohol (ethanol, isopropanol) or a chlorinated solvent (chloroform, dichloromethane). Filtration and sterilization steps can be carried out thereafter. According to a variant of the process, this extract can be redissolved in order to carry out a crystallization step with the aim of eliminating neutral lipids and / or enriching it with sterolic compounds and / or terpene acid. This step can advantageously be carried out before the total evaporation of the extraction solvent (ethanol or chloroform) if the latter authorizes it. The extract obtained can then contain between 5 and 90% of phytosterols and between 10 and 90% of ursolic acid.
L'extrait évaporé est, par la suite, remis en solution, ou dispersé, dans un solvant adapté à l'usage cosmétique, de préférence dans un solvant lipidique tel qu'un alcool gras comme l'hexyldécanol, à la concentration de 3%.The evaporated extract is subsequently redissolved, or dispersed, in a solvent suitable for cosmetic use, preferably in a lipid solvent such as a fatty alcohol such as hydroxyldecanol, at a concentration of 3%. .
Selon un autre aspect, l'invention a pour objet une composition contenant, comme principe actif, dans un milieu cosmétiquement ou pharmaceutiquement acceptable, au moins un extrait de marc de poire tel que défini précédemment. La composition selon l'invention peut être une composition cosmétique et/ou dermatologique et/ou pharmaceutique. Preferentiellement selon l'invention, la composition est une composition cosmétique, car elle est destinée à améliorer l'aspect et les performances cutanées générales de l'individu qui en fait usage. La composition selon l'invention est preferentiellement une composition cosmétique et/ou dermatologique adaptée à l'administration par voie topique cutanée comprenant un milieu cosmétiquement ou dermatologiquement acceptable.According to another aspect, the subject of the invention is a composition containing, as active principle, in a cosmetically or pharmaceutically acceptable medium, at least one extract of pear marc as defined above. The composition according to the invention can be a cosmetic and / or dermatological and / or pharmaceutical composition. Preferably according to the invention, the composition is a cosmetic composition, because it is intended to improve the appearance and the general cutaneous performance of the individual who uses it. The composition according to the invention is preferably a cosmetic and / or dermatological composition suitable for administration by the topical skin route comprising a cosmetically or dermatologically acceptable medium.
Il est bien évident que l'invention s'adresse aux mammifères en général et plus particulièrement aux êtres humains. La quantité d'extrait utilisable selon l'invention est, bien entendu, fonction de l'effet recherché et peut donc varier dans une large mesure. Pour donner un ordre de grandeur, on peut utiliser l'extrait de marc de poire précité, dans les compositions de l'invention, en une quantité représentant entre 0,00001 % et 20 % environ, du poids total de la composition, et preferentiellement, en une quantité représentant entre 0,0001 % et 5 %, environ, par rapport au poids total de la composition finale.It is obvious that the invention is intended for mammals in general and more particularly for human beings. The amount of extract usable according to the invention is, of course, a function of the desired effect and can therefore vary to a large extent. To give an order of magnitude, the abovementioned pear marc extract can be used, in the compositions of the invention, in an amount representing between 0.00001% and 20% approximately, of the total weight of the composition, and preferably , in an amount representing between 0.0001% and 5%, approximately, relative to the total weight of the final composition.
L'extrait de marc de poire, selon l'invention, peut être utilisé sous forme pure ou en solution dans un ou plusieurs solvants adaptés à la cosmétique ou à la pharmaceutique. Selon un mode de réalisation avantageux de l'invention, l'extrait précité est préalablement solubilisé ou dispersé dans un ou plusieurs solvants cosmétiquement ou pharmaceutiquement acceptables comme Péthanol, le propanol ou l'isopropanol, le propylène glycol, le butylène glycol, le dipropylène glycol, les diglycols éthoxylés ou propoxylés ou tout mélange de ces solvants.The pear marc extract according to the invention can be used in pure form or in solution in one or more solvents suitable for cosmetics or pharmaceuticals. According to an advantageous embodiment of the invention, the above-mentioned extract is dissolved beforehand or dispersed in one or more cosmetically or pharmaceutically acceptable solvents such as ethanol, propanol or isopropanol, propylene glycol, butylene glycol, dipropylene glycol , ethoxylated or propoxylated diglycols or any mixture of these solvents.
Selon encore un autre mode de réalisation avantageux de l'invention, l'extrait de marc de poire est préalablement solubilisé dans un vecteur cosmétique ou pharmaceutique comme les liposomes ou adsorbé sur des polymères organiques poudreux, des supports minéraux comme les talcs et bentonites, et plus généralement solubilisé dans, ou fixé sur, tout vecteur cosmétiquement ou pharmaceutiquement acceptable.According to yet another advantageous embodiment of the invention, the pear marc extract is dissolved beforehand in a cosmetic or pharmaceutical carrier such as liposomes or adsorbed on powdery organic polymers, mineral supports such as talcs and bentonites, and more generally solubilized in, or attached to, any cosmetically or pharmaceutically acceptable carrier.
Quelle que soit la forme de l'invention, la composition selon l'invention peut être ingérée, injectée ou appliquée sur la peau (sur toute zone cutanée du corps), les cheveux, les ongles ou les muqueuses. Selon le mode d'administration, la composition selon l'invention peut se présenter sous toutes les formes galéniques normalement utilisées. Préférentiellement, les compositions selon la présente invention se présenteront sous une forme galenique adaptée à l'administration par voie topique cutanée. Elles couvrent toutes les formes cosmétiques ou dermatologiques. Ces compositions doivent donc contenir un milieu cosmétiquement acceptable, c'est-à-dire compatible avec la peau, les poils ou les cheveux.Whatever the form of the invention, the composition according to the invention can be ingested, injected or applied to the skin (on any cutaneous zone of the body), the hair, the nails or the mucous membranes. Depending on the mode of administration, the composition according to the invention can be in all the galenical forms normally used. Preferably, the compositions according to the present invention will be presented in a galenical form suitable for administration by the topical cutaneous route. They cover all cosmetic and dermatological forms. These compositions must therefore contain a cosmetically acceptable medium, that is to say compatible with the skin, hair or hair.
Ces compositions peuvent notamment se présenter sous forme d'une solution aqueuse, hydralcoolique ou huileuse ; d'une émulsion huile-dans-eau, eau-dans-huile ou émulsions multiples ; elles peuvent aussi se présenter sous forme de crèmes, de suspensions ou encore de poudres, adaptées à une application sur la peau, les muqueuses, les lèvres et/ou les cheveux.These compositions can in particular be in the form of an aqueous, hydroalcoholic or oily solution; an oil-in-water, water-in-oil or multiple emulsion; they can also be in the form of creams, suspensions or even powders, suitable for application to the skin, mucous membranes, lips and / or hair.
Ces compositions peuvent être plus ou moins fluides et avoir l'aspect d'une crème, d'une lotion, d'un lait, d'un sérum, d'une pommade, d'un shampooing, d'un gel, d'une pâte ou d'une mousse. Elles peuvent aussi se présenter sous forme solide, comme un stick, ou être appliquées sur la peau sous forme d'aérosol. Elles peuvent être utilisées comme produit de soin et/ou comme produit de maquillage de la peau.These compositions can be more or less fluid and have the appearance of a cream, a lotion, a milk, a serum, an ointment, a shampoo, a gel, a paste or foam. They can also be in solid form, such as a stick, or be applied to the skin in the form of an aerosol. They can be used as a care product and / or as a make-up product for the skin.
Pour l'injection, la composition selon l'invention peut se présenter sous forme de lotion aqueuse, huileuse ou sous forme de sérum. Pour l'application sur les yeux, la composition peut se présenter sous forme de gouttes et pour l'ingestion, elle peut se présenter sous forme de capsules, de granulés, de sirops ou de comprimés.For injection, the composition according to the invention can be in the form of an aqueous, oily lotion or in the form of serum. For application to the eyes, the composition can be in the form of drops and for ingestion, it can be in the form of capsules, granules, syrups or tablets.
Ces compositions comprennent, en outre, tout additif usuellement utilisé dans le domaine d'application envisagé ainsi que les adjuvants nécessaires à leur formulation, tels que des solvants, des épaississants, des diluants, des anti-oxydants, des colorants, des filtres solaires, des agents auto-bronzants, des pigments, des charges, des conservateurs, des parfums, des absorbeurs d'odeur, des actifs cosmétiques ou pharmaceutiques, des huiles essentielles, des vitamines, des acides gras essentiels, des tensioactifs, des polymères filmogènes, etc....These compositions also include any additive commonly used in the intended field of application as well as the adjuvants necessary for their formulation, such as solvents, thickeners, diluents, antioxidants, dyes, sunscreens, self-tanning agents, pigments, fillers, preservatives, perfumes, odor absorbers, cosmetic or pharmaceutical active ingredients, essential oils, vitamins, essential fatty acids, surfactants, film-forming polymers, etc. ....
Dans tous les cas, l'homme du métier veillera à ce que ces adjuvants ainsi que leurs proportions soient choisis de telle manière à ne pas nuire aux propriétés avantageuses recherchées de la composition selon l'invention. Ces adjuvants peuvent, par exemple, correspondre de 0,01 à 20 % du poids total de la composition.In all cases, a person skilled in the art will take care that these adjuvants, as well as their proportions, are chosen so as not to harm the desired advantageous properties of the composition according to the invention. These adjuvants can, for example, correspond from 0.01 to 20% of the total weight of the composition.
Lorsque la composition de l'invention est une émulsion, la phase grasse peut représenter de 5 à 80 % en poids et de préférence de 5 à 50 % en poids par rapport au poids total de la composition. Les émulsionnants et co-émulsionnants utilisés dans la composition seront choisis parmi ceux classiquement utilisés dans le domaine considéré. Par exemple, ils peuvent être utilisés en une proportion allant de 0,3 à 30 % en poids, par rapport au poids total de la composition. Bien entendu, l'homme du métier veillera à choisir les éventuels composés complémentaires, actifs ou non-actifs, et/ou leurs quantités, de telle sorte que les propriétés avantageuses du mélange ne soient pas, ou sensiblement pas, altérées par l'adjonction envisagée.When the composition of the invention is an emulsion, the fatty phase may represent from 5 to 80% by weight and preferably from 5 to 50% by weight relative to the total weight of the composition. The emulsifiers and co-emulsifiers used in the composition will be chosen from those conventionally used in the field under consideration. For example, they can be used in a proportion ranging from 0.3 to 30% by weight, relative to the total weight of the composition. Of course, those skilled in the art will take care to choose any additional compounds, active or non-active, and / or their quantities, so that the advantageous properties of the mixture are not, or not substantially, altered by the addition considered.
Les compositions selon l'invention trouvent une application notamment comme composition cosmétique ou pharmaceutique pour la peau, les muqueuses et/ou les semi- muqueuses, mais aussi comme composition cosmétique pour les cheveux et/ou les poils.The compositions according to the invention find application in particular as a cosmetic or pharmaceutical composition for the skin, mucous membranes and / or semi-mucous membranes, but also as a cosmetic composition for the hair and / or body hair.
Elles trouvent une application toute particulière en tant que produit de protection et/ou de soin de la peau.They find a very particular application as a product for protecting and / or caring for the skin.
On peut également envisager une application dans le domaine des compositions de maquillage de la peau du visage et du corps, tels que les rouges à lèvres, les fonds de teint, les crèmes teintées, les sticks anti-cernes, les compositions anti-solaires ou de bronzage artificiel.One can also envisage an application in the field of makeup compositions for the skin of the face and the body, such as lipsticks, foundations, tinted creams, concealer sticks, anti-sun compositions or artificial tanning.
Les compositions, objet de l'invention, trouvent leur application dans grand nombre de traitements notamment cosmétiques ou dermatologiques, et elles peuvent constituer une composition cosmétique, notamment pour le traitement, la protection, le soin, le démaquillage et/ou le nettoyage de la peau, des lèvres et/ou des cheveux, et/ou pour le maquillage de la peau, des lèvres, des cils et/ou du corps.The compositions which are the subject of the invention find their application in a large number of treatments, in particular cosmetic or dermatological treatments, and they can constitute a cosmetic composition, in particular for the treatment, protection, care, make-up removal and / or cleaning of the skin, lips and / or hair, and / or for making up the skin, lips, eyelashes and / or body.
La composition selon l'invention peut également consister en des préparations solides comprenant également des savons ou des pains de nettoyage. La composition peut être aussi conditionnée sous forme d'une composition pour aérosol comprenant également un agent propulseur sous pression.The composition according to the invention may also consist of solid preparations also comprising soaps or cleaning bars. The composition can also be packaged in the form of an aerosol composition also comprising a propellant under pressure.
La composition peut être aussi à usage bucco-dentaire comme par exemple une pâte de dentifrice.The composition can also be for oral use, for example a toothpaste paste.
La composition de l'invention peut aussi être une composition cosmétique destinée à une administration par voie orale. Pour une administration par voie orale, la composition selon l'invention peut se présenter sous toutes formes adaptées, particulièrement sous forme d'une solution buvable, d'un sirop, d'un comprimé, d'une dragée, d'une gélule ou encore d'un aliment ou complément nutritionnel. Selon l'invention, on peut, entre autres, ajouter à la composition de l'invention d'autres agents actifs destinés notamment à la prévention et/ou au traitement des manifestations cutanées du vieillissement.The composition of the invention can also be a cosmetic composition intended for oral administration. For oral administration, the composition according to the invention can be in any suitable form, particularly in the form of an oral solution, a syrup, a tablet, a dragee, a capsule or still a food or nutritional supplement. According to the invention, it is possible, among other things, to add to the composition of the invention other active agents intended in particular for the prevention and / or treatment of the cutaneous manifestations of aging.
L'invention également concerne un procédé cosmétique destiné à traiter les manifestations cutanées du vieillissement, consistant à appliquer, sur la peau, une composition, telle que définie précédemment, comprenant, au moins, un extrait de marc de poire.The invention also relates to a cosmetic process intended to treat the cutaneous manifestations of aging, consisting in applying, to the skin, a composition, as defined above, comprising, at least, an extract of pear marc.
L'invention concerne aussi un procédé cosmétique destiné à diminuer les rides et/ou les ridules de la peau, et/ou à lisser la peau, consistant à appliquer sur la peau la composition telle que définie précédemment.The invention also relates to a cosmetic process intended to reduce wrinkles and / or fine lines on the skin, and / or to smooth the skin, consisting in applying the composition as defined above to the skin.
L'invention concerne également un procédé de traitement cosmétique destiné à lutter contre la peau flétrie et/ou à lutter contre la peau amincie et/ou à lutter contre la peau molle et/ou à lutter contre le manque d'élasticité et/ou de tonus de la peau, consistant à appliquer, sur la peau, une composition telle que définie précédemment comprenant au moins un extrait de marc de poire.The invention also relates to a cosmetic treatment method intended to fight against withered skin and / or to fight against thinned skin and / or to fight against soft skin and / or to fight against lack of elasticity and / or skin tone, consisting in applying, to the skin, a composition as defined above comprising at least one extract of pear marc.
L'invention concerne aussi un procédé de traitement cosmétique destiné à hydrater la peau et/ou à protéger la peau contre tous types d'agressions extérieures, consistant à appliquer sur la peau une composition telle que définie précédemment comprenant au moins un extrait de marc de poire.The invention also relates to a cosmetic treatment method intended to hydrate the skin and / or protect the skin against all types of external aggression, consisting in applying to the skin a composition as defined above comprising at least one marc extract. Pear.
Des modes de réalisation particuliers de ce procédé de traitement cosmétique résultent également de la description précédente.Particular embodiments of this cosmetic treatment process also result from the preceding description.
Le procédé de traitement cosmétique de l'invention peut être mis en oeuvre notamment en appliquant les compositions cosmétiques telles que définies ci-dessus, selon la technique d'utilisation habituelle de ces compositions, par exemple : application de crèmes, de gels, de sérums, de lotions, de laits, de shampooings ou de compositions antisolaires, sur la peau ou sur les cheveux, ou encore, application de dentifrice sur les gencives.The cosmetic treatment process of the invention can be implemented in particular by applying the cosmetic compositions as defined above, according to the usual technique for using these compositions, for example: application of creams, gels, serums , lotions, milks, shampoos or sunscreen compositions, on the skin or on the hair, or else application of toothpaste on the gums.
D'autres avantages et caractéristiques de l'invention apparaîtront mieux à la lecture des exemples donnés à titre illustratif et non limitatif. Exemple 1 - Préparation d'un extrait de marc de poire.Other advantages and characteristics of the invention will appear better on reading the examples given by way of illustration and without limitation. Example 1 - Preparation of a pear marc extract.
Dans une première étape un kilogramme de poire est trié, lavé énergiquement à l'eau claire et séché. Ces fruits sont ensuite pressés dans une presse à tapis ou à bande. On récupère alors entre 100 et 300 g de résidu de ces fruits, appelé marc ou drêche. Le pressage est progressif afin d'éviter l'obstruction des canaux d'écoulement du jus, son intensité est fonction de la maturité du fruit.In a first step, a kilogram of pear is sorted, washed vigorously with clean water and dried. These fruits are then pressed in a belt or belt press. We then recover between 100 and 300 g of residue from these fruits, called marc or drake. The pressing is progressive in order to avoid obstruction of the juice flow channels, its intensity depends on the maturity of the fruit.
Le marc est ensuite mis en suspension dans 2 à 10 fois son volume d'eau, dans une cuve sous agitation constante. Une quantité, comprise entre 0,01 et 0,1 g par kg de fruit, d'un complexe enzymatique pectolytique et dépolymérisant, provenant d'Aspergillus, est additionnée. Le milieu est maintenu, sous agitation, à une température comprise entreThe marc is then suspended in 2 to 10 times its volume of water, in a tank with constant stirring. An amount, between 0.01 and 0.1 g per kg of fruit, of a pectolytic and depolymerizing enzyme complex, originating from Aspergillus, is added. The medium is kept, with stirring, at a temperature between
15 et 40°C, durant une période de 1 à 24 heures.15 and 40 ° C, for a period of 1 to 24 hours.
Après cette digestion enzymatique, le milieu est transféré sur un tamis de maille 0,2 à 3 mm (ou sur une essoreuse équipée de maille similaire ou bien, encore, centrifugé) afin de séparer les éléments solubles présents dans le résidu.After this enzymatic digestion, the medium is transferred to a 0.2 to 3 mm mesh sieve (or to a wringer with a similar mesh or, again, centrifuged) in order to separate the soluble elements present in the residue.
Ce résidu est alors lavé jusqu'à l'obtention d'un résidu insoluble composé en grande partie de graines et de peaux de fruit. Ce résidu est alors séché dans une étuve, et broyé à l'aide d'un broyeur à plante approprié, preferentiellement dans un broyeur à marteaux.This residue is then washed until an insoluble residue composed largely of seeds and fruit skins is obtained. This residue is then dried in an oven, and crushed using an appropriate plant grinder, preferably in a hammer mill.
La poudre est ensuite extraite à l'aide d'un solvant organique (ou d'un mélange de solvant). De préférence, le solvant utilisé sera un alcool (éthanol ou isopropanol).The powder is then extracted using an organic solvent (or a mixture of solvents). Preferably, the solvent used will be an alcohol (ethanol or isopropanol).
Cette extraction est réalisée dans un extracteur sous agitation ou, d'une manière classique, dans un extracteur à plante, par circulation du solvant. La température de l'extraction varie de la température ambiante à la température du reflux du solvant. Le solvant d'extraction est ensuite filtré puis évaporé.This extraction is carried out in a stirred extractor or, in a conventional manner, in a plant extractor, by circulation of the solvent. The temperature of the extraction varies from room temperature to the reflux temperature of the solvent. The extraction solvent is then filtered and then evaporated.
On obtient alors un extrait cireux de couleur verte qui peut être utilisé en l'état, titrant entre 5 et 30 % de phytostérol et entre 10 et 30 % d'acide ursolique. Des étapes de filtration et de stérilisation peuvent être effectuées par la suite.A waxy extract of green color is then obtained which can be used as it is, titrating between 5 and 30% of phytosterol and between 10 and 30% of ursolic acid. Filtration and sterilization steps can be carried out thereafter.
L'extrait est, ultérieurement, dispersé dans un solvant adapté à l'usage cosmétique, comme l'hexyldécanol, à la concentration de 3%.The extract is subsequently dispersed in a solvent suitable for cosmetic use, such as hydroxyldecanol, at a concentration of 3%.
Cet essai est utilisé dans les exemples suivants sous le nom « extrait de l'exemple 1 ». Exemple 2 - Effets de l'extrait de l'exemple 1 sur la peau et sur les manifestations du vieillissement cutanéThis test is used in the following examples under the name "extract from Example 1". Example 2 - Effects of the extract of Example 1 on the skin and on the manifestations of skin aging
Principe : Une étude clinique a été réalisée, en double aveugle, sur un groupe de vingt volontaires, afin de mettre en évidence l'effet de l'exemple 1 sur l'amélioration du relief cutané et, plus particulièrement, son action sur l'état des rides.Principle: A clinical study was carried out, double blind, on a group of twenty volunteers, in order to highlight the effect of Example 1 on the improvement of the skin relief and, more particularly, its action on the condition of wrinkles.
Matériel et Méthodes : L'étude a été réalisée sur un groupe de vingt femmes volontaires, âgées de 40 à 62 ans, présentant une peau saine ainsi que des rides modérées ou accentuées. Les sujets sélectionnés pour l'étude possédaient le même type de rides sur chaque côté du visage.Material and Methods: The study was carried out on a group of twenty women volunteers, aged 40 to 62, with healthy skin as well as moderate or accentuated wrinkles. The subjects selected for the study had the same type of wrinkles on each side of the face.
Les volontaires ont appliqué l'extrait de l'exemple 1, formulé à 2,5 % dans une crème, sur la zone du contour de l'œil, d'un côté du visage ; la zone du contour de l'oeil de l'autre côté du visage étant utilisée pour l'application du placebo. Les volontaires ont ainsi appliqué le produit, dosé à 2 mg/cm2, deux fois par jour, durant 8 semaines.The volunteers applied the extract of Example 1, formulated at 2.5% in a cream, to the area around the eye, on one side of the face; the area around the eye on the other side of the face being used for the application of the placebo. The volunteers thus applied the product, dosed at 2 mg / cm 2 , twice a day, for 8 weeks.
L'évolution du relief cutané et de l'état des rides a été évalué après observation clinique (par l'utilisation de photos), ainsi que par une analyse de la surface de la peau à l'aide de répliques de silicone. L'étude a comporté neuf visites de contrôle : une visite avant le début du traitement (T0), et une visite chaque semaine pendant 8 semaines. Des photos ont été prises à T0 et T8 à l'aide d'une caméra vidéo (COHU High performance CDD caméra) et des empreintes négatives de silicone de la surface cutanée ont été réalisées, à l'aide de différents marqueurs, au niveau de la zone du contour de l'œil. Les photos des empreintes ont été prises sous lumière oblique, utilisant la caméra décrite précédemment. La mesure du relief cutané a été obtenue par analyse d'image, après utilisation d'un logiciel spécifique (Quantirides, Monaderm) permettant de calculer les paramètres standards des rides tels que le nombre, la surface complète (en mm2) et la longueur totale (en mm).The evolution of the skin relief and the condition of wrinkles was evaluated after clinical observation (by the use of photos), as well as by an analysis of the surface of the skin using replicas of silicone. The study included nine follow-up visits: one visit before the start of treatment (T0), and one visit every week for 8 weeks. Photos were taken at T0 and T8 using a video camera (COHU High performance CDD camera) and negative impressions of silicone on the skin surface were made, using different markers, at the area around the eye. The photos of the prints were taken under oblique light, using the camera described above. The skin relief measurement was obtained by image analysis, after using a specific software (Quantirides, Monaderm) allowing to calculate the standard parameters of wrinkles such as the number, the complete surface (in mm 2 ) and the length total (in mm).
RésultatsResults
Les résultats, obtenus par analyse d'images par Quantirides, ainsi que par le traitement statistique des données, selon le test de Wilcoxon, sont présentés dans le tableau ci- dessous. L'analyse statistique a été réalisée en utilisant le test non paramétrique de Wilcoxon pour les séries appariées, pour chaque sujet. Le résultat est obtenu selon le calcul suivant :The results, obtained by image analysis by Quantirides, as well as by the statistical processing of the data, according to the Wilcoxon test, are presented in the table below. Statistical analysis was performed using the non-parametric Wilcoxon test for the matched series, for each subject. The result is obtained according to the following calculation:
Score = Diff. A/Un OU PI = T8 A/Un OU PI - T0 A/Un OU PIScore = Diff. A / One OR PI = T8 A / One OR PI - T0 A / One OR PI
A = Actif ; Un = Non traité ; PI = PlaceboA = Active; Un = Untreated; PI = Placebo
Région de rejet : dans la mesure ou le sens de la différence est prédictible, la région de rejet sera unilatérale. Le niveau de significativité est α 5 %.Rejection region: as far as the difference is predictable, the rejection region will be unilateral. The level of significance is at 5%.
Figure imgf000013_0001
Figure imgf000013_0001
Les résultats, donnés par les répliques de silicones, démontrent qu'en appliquant sur la peau l'extrait de marc de poire selon l'exemple 1, on réduit significativement le nombre de rides (-15,5 %) ainsi que la profondeur de ces rides (- 5,5 %), ces résultats étant calculés par rapport à l'effet obtenu en appliquant uniquement le placebo. D'une manière particulièrement intéressante, on obtient des résultats significatifs sur la réduction de la surface totale des rides (-37,9 %), sur leur longueur (-24,4 %) ainsi que sur la moyenne de leur longueur (-13,6 %).The results, given by the replicas of silicones, demonstrate that by applying the pear marc extract according to Example 1 to the skin, the number of wrinkles is significantly reduced (-15.5%) as well as the depth of these wrinkles (- 5.5%), these results being calculated in relation to the effect obtained by applying only the placebo. In a particularly interesting way, we obtain significant results on the reduction of the total surface of wrinkles (-37.9%), on their length (-24.4%) as well as on the average of their length (-13 , 6%).
Ces résultats ont, par ailleurs, été confirmés après examen clinique : 90 % des volontaires ont présenté une diminution de leurs rides, ainsi qu'une amélioration de l'hydratation et de la souplesse de leur peau. Exemple 3 - Préparation de compositionsThese results have also been confirmed after clinical examination: 90% of the volunteers presented a reduction in their wrinkles, as well as an improvement in the hydration and suppleness of their skin. Example 3 Preparation of Compositions
Ces compositions ont été obtenues par simple mélange des différents composants. Les quantités indiquées sont données en pourcentage de poids.These compositions were obtained by simple mixing of the various components. The quantities indicated are given as a percentage by weight.
Emulsion huile-dans-eauOil-in-water emulsion
Phase huileuse :Oily phase:
• Montanov 68 (Cetearyl Alcohol and Cetearyl Glucoside) 5.00 % - Huile de Jojoba 5.00 %• Montanov 68 (Cetearyl Alcohol and Cetearyl Glucoside) 5.00% - Jojoba Oil 5.00%
• Huile de Vaseline 5.00 % - Isopropyl Palmitate 7.00 %• Vaseline oil 5.00% - Isopropyl Palmitate 7.00%
Phase aqueuse :Aqueous phase :
Glycérine 5.00 %Glycerin 5.00%
Allantoïne 0.10 %Allantoin 0.10%
Extrait de l'exemple 1 5.00 %Extract from example 1 5.00%
Sepigel 305 (Polyacrylamide and C13-14 Isoparaffm and Laureth-7) 0.30 %Sepigel 305 (Polyacrylamide and C13-14 Isoparaffm and Laureth-7) 0.30%
Conservateur 0.50 %Preservative 0.50%
Parfum 0.50 %Perfume 0.50%
Eau qsp 100 % Water qs 100%

Claims

RENENDICATIONS RENENDICATIONS
1. Utilisation d'une quantité efficace d'au moins un extrait de marc de poire comme principe actif dans ou pour la préparation d'une composition cosmétique et/ou dermatologique et/ou pharmaceutique.1. Use of an effective amount of at least one pear marc extract as active ingredient in or for the preparation of a cosmetic and / or dermatological and / or pharmaceutical composition.
2. Utilisation selon la revendication 1, caractérisée en ce que le marc de poire est constitué, en majorité, de peaux et de pépins de poire.2. Use according to claim 1, characterized in that the pear marc consists, for the most part, of skins and pear seeds.
3. Utilisation selon la revendication 1, caractérisée en ce que le marc de poire est constitué de pépins de poire.3. Use according to claim 1, characterized in that the pear marc consists of pear seeds.
4. Utilisation selon l'une quelconque des revendications précédentes, caractérisée en ce que l'extrait comprend au moins un composé tel que les phytostéroïdes, les phytostérols ou l'acide ursolique.4. Use according to any one of the preceding claims, characterized in that the extract comprises at least one compound such as phytosteroids, phytosterols or ursolic acid.
5. Utilisation selon l'une quelconque des revendications précédentes, caractérisée en ce que l'extrait comprend entre 10 et 40 % d'acide ursolique.5. Use according to any one of the preceding claims, characterized in that the extract comprises between 10 and 40% of ursolic acid.
6. Utilisation selon l'une quelconque des revendications précédentes, caractérisée en ce que l'extrait comprend entre 5 et 30 % de phytostérols.6. Use according to any one of the preceding claims, characterized in that the extract comprises between 5 and 30% of phytosterols.
7. Utilisation d'une quantité efficace d'au moins un extrait de marc de poire selon l'une quelconque des revendications 1 à 6, dans ou pour la préparation d'une composition, l'extrait ou la composition étant destinés à traiter de manière curative et/ou préventive les manifestations cutanées du vieillissement.7. Use of an effective amount of at least one pear marc extract according to any one of claims 1 to 6, in or for the preparation of a composition, the extract or the composition being intended to treat curative and / or preventive skin manifestations of aging.
8. Utilisation d'une quantité efficace d'au moins un extrait de marc de poire selon l'une quelconque des revendications 1 à 6, dans ou pour la préparation d'une composition, l'extrait ou la composition étant destinés à diminuer les rides et/ou les ridules ; et/ou à lisser la peau. 8. Use of an effective amount of at least one pear marc extract according to any one of claims 1 to 6, in or for the preparation of a composition, the extract or the composition being intended to reduce the wrinkles and / or fine lines; and / or to smooth the skin.
9. Utilisation d'une quantité efficace d'au moins un extrait de marc de poire selon l'une quelconque des revendications 1 à 6, dans ou pour la préparation d'une composition, l'extrait ou la composition étant destinés à lutter contre la peau flétrie et/ou à lutter contre la peau molle et/ou à lutter contre la peau amincie et/ou à lutter contre le manque d'élasticité et/ou de tonus de la peau.9. Use of an effective amount of at least one pear marc extract according to any one of claims 1 to 6, in or for the preparation of a composition, the extract or the composition being intended for combating withered skin and / or to fight against soft skin and / or to fight against thinned skin and / or to fight against lack of elasticity and / or tone of the skin.
10. Utilisation d'une quantité efficace d'au moins un extrait de marc de poire selon l'une quelconque des revendications 1 à 6, dans ou pour la préparation d'une composition ; l'extrait ou la composition étant destinés à augmenter la synthèse des protéines de la matrice extra-cellulaire, et plus particulièrement à augmenter la synthèse du collagène.10. Use of an effective amount of at least one pear marc extract according to any one of claims 1 to 6, in or for the preparation of a composition; the extract or the composition being intended to increase the synthesis of proteins of the extracellular matrix, and more particularly to increase the synthesis of collagen.
11. Utilisation d'une quantité efficace d'au moins un extrait de marc de poire selon l'une quelconque des revendications 1 à 6, dans ou pour la préparation d'une composition, l'extrait ou la composition étant destinés à hydrater la peau et/ou à protéger la peau contre tous types d'agressions extérieures.11. Use of an effective amount of at least one pear marc extract according to any one of claims 1 to 6, in or for the preparation of a composition, the extract or the composition being intended to hydrate the and / or protect the skin against all types of external aggression.
12. Composition cosmétique et/ou dermatologique et/ou pharmaceutique, caractérisée en ce qu'elle contient, dans un milieu cosmétiquement ou dermatologiquement acceptable, au moins un extrait de marc de poire tel que défini dans l'une quelconque des revendications 1 à 6.12. Cosmetic and / or dermatological and / or pharmaceutical composition, characterized in that it contains, in a cosmetically or dermatologically acceptable medium, at least one extract of pear marc as defined in any one of claims 1 to 6 .
13. Composition selon la revendication 12, caractérisée en ce qu'elle se présente sous la forme d'une composition cosmétique et/ou dermatologique adaptée à l'administration par voie topique cutanée comprenant un milieu cosmétiquement ou pharmaceutiquement acceptable.13. Composition according to claim 12, characterized in that it is in the form of a cosmetic and / or dermatological composition suitable for administration by the topical skin route comprising a cosmetically or pharmaceutically acceptable medium.
14. Composition selon l'une quelconque des revendications 12 ou 13, caractérisée en ce que l'extrait de marc de poire est présent en une quantité représentant de 0,00001 % à 20 % du poids total de la composition, et preferentiellement en une quantité représentant de 0,001 % à 10 % du poids total de la composition. 14. Composition according to any one of claims 12 or 13, characterized in that the pear marc extract is present in an amount representing from 0.00001% to 20% of the total weight of the composition, and preferably in one amount representing from 0.001% to 10% of the total weight of the composition.
15. Composition selon l'une quelconque des revendications 12 à 14, caractérisée en ce que l'extrait est préalablement solubilisé ou dispersé dans un ou plusieurs solvants cosmétiquement ou pharmaceutiquement acceptables comme l 'éthanol, le propanol ou Fisopropanol, le propylène glycol, le butylène glycol, le dipropylène glycol, les diglycols éthoxylés ou propoxylés ou tout mélange de ces solvants.15. Composition according to any one of claims 12 to 14, characterized in that the extract is previously dissolved or dispersed in one or more cosmetically or pharmaceutically acceptable solvents such as ethanol, propanol or Fisopropanol, propylene glycol, butylene glycol, dipropylene glycol, ethoxylated or propoxylated diglycols or any mixture of these solvents.
16. Composition selon l'une quelconque des revendications 12 à 15, caractérisée en ce que l'extrait est préalablement solubilisé dans un vecteur cosmétique ou pharmaceutique comme les liposomes ou adsorbés sur des polymères organiques poudreux, des supports minéraux comme les talcs et bentonites, et plus généralement solubilisés dans, ou fixés sur, tout vecteur cosmétiquement ou pharmaceutiquement acceptable.16. Composition according to any one of claims 12 to 15, characterized in that the extract is dissolved beforehand in a cosmetic or pharmaceutical carrier such as liposomes or adsorbed on powdery organic polymers, mineral supports such as talcs and bentonites, and more generally solubilized in, or attached to, any cosmetically or pharmaceutically acceptable carrier.
17. Composition selon l'une quelconque des revendications 12 à 16, caractérisée en ce qu'elle se présente sous forme d'une solution aqueuse, hydralcoolique ou huileuse ou sous la forme d'une émulsion huile-dans-eau, eau-dans-huile ou émulsions multiples ou sous forme de crèmes, de suspensions ou encore de poudres ; ces compositions pouvant être plus ou moins fluides ou solides et avoir l'aspect d'une crème, d'une lotion, d'un lait, d'un sérum, d'une pommade, d'un gel, d'une pâte, d'une mousse ou d'un stick17. Composition according to any one of claims 12 to 16, characterized in that it is in the form of an aqueous, hydroalcoholic or oily solution or in the form of an oil-in-water, water-in emulsion -multiple oil or emulsions or in the form of creams, suspensions or even powders; these compositions possibly being more or less fluid or solid and having the appearance of a cream, a lotion, a milk, a serum, an ointment, a gel, a paste, foam or stick
18. Procédé de traitement cosmétique de la peau destiné à traiter les manifestations cutanées du vieillissement ; et/ou destiné à hydrater la peau et/ou à protéger la peau contre tous types d'agressions extérieures, caractérisé par le fait que l'on applique sur la peau une composition cosmétique définie selon l'une quelconque des revendications 12 à 17. 18. A method of cosmetic treatment of the skin intended to treat the cutaneous manifestations of aging; and / or intended to hydrate the skin and / or to protect the skin against all types of external aggression, characterized in that a cosmetic composition defined according to any one of claims 12 to 17 is applied to the skin.
PCT/FR2003/002876 2002-10-02 2003-10-01 Use of a pear must extract as active principle in a cosmetic and/or pharmaceutical composition WO2004030645A1 (en)

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WO2008027533A2 (en) * 2006-08-30 2008-03-06 The Procter & Gamble Company Personal care compositions comprising pear seed extract
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