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WO2004028456A3 - Method and composition for treating neurodegenerative disorders - Google Patents

Method and composition for treating neurodegenerative disorders Download PDF

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Publication number
WO2004028456A3
WO2004028456A3 PCT/US2003/030284 US0330284W WO2004028456A3 WO 2004028456 A3 WO2004028456 A3 WO 2004028456A3 US 0330284 W US0330284 W US 0330284W WO 2004028456 A3 WO2004028456 A3 WO 2004028456A3
Authority
WO
WIPO (PCT)
Prior art keywords
neurodegenerative disorders
composition
treating neurodegenerative
treating
methods
Prior art date
Application number
PCT/US2003/030284
Other languages
French (fr)
Other versions
WO2004028456A2 (en
Inventor
Adrian Hobden
Jean-Marc Roch
Original Assignee
Myriad Genetics Inc
Adrian Hobden
Jean-Marc Roch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Myriad Genetics Inc, Adrian Hobden, Jean-Marc Roch filed Critical Myriad Genetics Inc
Priority to AU2003278935A priority Critical patent/AU2003278935A1/en
Publication of WO2004028456A2 publication Critical patent/WO2004028456A2/en
Publication of WO2004028456A3 publication Critical patent/WO2004028456A3/en
Priority to US11/092,118 priority patent/US20050171207A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention provides compositions and methods for treating neurodegenerative disorders. The method of the invention involves administering to an individual in need of treatment a composition having an R-NSAID and an HMG-CoA reductase inhibitor. The methods and compositions of the invention are useful for treating and preventing neurodegenerative disorders like Alzheimer's disease, dementia, mild cognitive impairment
PCT/US2003/030284 2002-09-26 2003-09-26 Method and composition for treating neurodegenerative disorders WO2004028456A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003278935A AU2003278935A1 (en) 2002-09-26 2003-09-26 Method and composition for treating neurodegenerative disorders
US11/092,118 US20050171207A1 (en) 2003-09-26 2005-03-28 Method and composition for combination treatment of neurodegenerative disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41404502P 2002-09-26 2002-09-26
US60/414,045 2002-09-26

Publications (2)

Publication Number Publication Date
WO2004028456A2 WO2004028456A2 (en) 2004-04-08
WO2004028456A3 true WO2004028456A3 (en) 2004-06-17

Family

ID=32043333

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/030284 WO2004028456A2 (en) 2002-09-26 2003-09-26 Method and composition for treating neurodegenerative disorders

Country Status (2)

Country Link
AU (1) AU2003278935A1 (en)
WO (1) WO2004028456A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1658283A2 (en) 2003-05-30 2006-05-24 Ranbaxy Laboratories, Ltd. Substituted pyrrole derivatives and their use as hmg-co inhibitors
WO2006001877A2 (en) * 2004-04-13 2006-01-05 Myriad Genetics, Inc. Combination treatment for neurodegenerative disorders comprising r-flurbiprofen
JP2009514851A (en) * 2005-11-08 2009-04-09 ランバクシー ラボラトリーズ リミテッド (3R, 5R) -7- [2- (4-Fluorophenyl) -5-isopropyl-3-phenyl-4-[(4-hydroxymethylphenylamino) carbonyl] -pyrrol-1-yl] -3,5 -Preparation of dihydroxy-heptanoic acid hemi-calcium salt
CN104368002B (en) * 2014-10-17 2019-01-08 中国人民解放军军事医学科学院毒物药物研究所 For treating the combination medicine of dull-witted or cognition dysfunction

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365180B1 (en) * 1998-01-20 2002-04-02 Glenn A. Meyer Oral liquid compositions
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365180B1 (en) * 1998-01-20 2002-04-02 Glenn A. Meyer Oral liquid compositions
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents

Also Published As

Publication number Publication date
WO2004028456A2 (en) 2004-04-08
AU2003278935A1 (en) 2004-04-19
AU2003278935A8 (en) 2004-04-19

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