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WO2003072724A3 - Analogues humains de genes de protease murine liberatrice d'ubiquitine - Google Patents

Analogues humains de genes de protease murine liberatrice d'ubiquitine Download PDF

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Publication number
WO2003072724A3
WO2003072724A3 PCT/US2003/005338 US0305338W WO03072724A3 WO 2003072724 A3 WO2003072724 A3 WO 2003072724A3 US 0305338 W US0305338 W US 0305338W WO 03072724 A3 WO03072724 A3 WO 03072724A3
Authority
WO
WIPO (PCT)
Prior art keywords
murine
protease genes
human
human analogs
deubiquitinating protease
Prior art date
Application number
PCT/US2003/005338
Other languages
English (en)
Other versions
WO2003072724A2 (fr
Inventor
Chang Hahn
Hong Liu
Original Assignee
Aventis Pharma Inc
Chang Hahn
Hong Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0208404.4A external-priority patent/GB0208404D0/en
Application filed by Aventis Pharma Inc, Chang Hahn, Hong Liu filed Critical Aventis Pharma Inc
Priority to JP2003571412A priority Critical patent/JP2006512043A/ja
Priority to IL16352803A priority patent/IL163528A0/xx
Priority to AU2003215370A priority patent/AU2003215370B2/en
Priority to BR0307895-7A priority patent/BR0307895A/pt
Priority to CA002476770A priority patent/CA2476770A1/fr
Priority to MXPA04007760A priority patent/MXPA04007760A/es
Priority to EP03711195A priority patent/EP1534825A4/fr
Publication of WO2003072724A2 publication Critical patent/WO2003072724A2/fr
Publication of WO2003072724A3 publication Critical patent/WO2003072724A3/fr
Priority to AU2008203478A priority patent/AU2008203478A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des analogues humains de protéases murines de libération de l'ubiquitine ('DUB'), inductibles par cytokine et spécifiques du système hématopoïétique, groupés sur les chromosomes 4 et 8 et leurs régions régulatrices respectives. Les nucléotides ou les protéines codées ainsi peuvent être utilisés dans des tests d'identification d'inhibiteurs des DUB humaines.
PCT/US2003/005338 2002-02-22 2003-02-20 Analogues humains de genes de protease murine liberatrice d'ubiquitine WO2003072724A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2003571412A JP2006512043A (ja) 2002-02-22 2003-02-20 マウスの脱ユビキチン化プロテアーゼ遺伝子のヒト類似体
IL16352803A IL163528A0 (en) 2002-02-22 2003-02-20 Human analogs of murine deubiquitinating protease genes
AU2003215370A AU2003215370B2 (en) 2002-02-22 2003-02-20 Human analogs of murine deubiquitinating protease genes
BR0307895-7A BR0307895A (pt) 2002-02-22 2003-02-20 Análogos humanos dos genes murinos da protease de desubiquitinação
CA002476770A CA2476770A1 (fr) 2002-02-22 2003-02-20 Analogues humains de genes de protease murine liberatrice d'ubiquitine
MXPA04007760A MXPA04007760A (es) 2002-02-22 2003-02-20 Analogos humanos de los genes de proteasa desubiquitinantes.
EP03711195A EP1534825A4 (fr) 2002-02-22 2003-02-20 Analogues humains de genes de protease murine liberatrice d'ubiquitine
AU2008203478A AU2008203478A1 (en) 2002-02-22 2008-08-04 Human analogs of murine deubiquitinating protease genes

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US35887502P 2002-02-22 2002-02-22
US35887302P 2002-02-22 2002-02-22
US60/358,875 2002-02-22
US60/358,873 2002-02-22
US36302002P 2002-03-08 2002-03-08
US60/363,020 2002-03-08
GBGB0208404.4A GB0208404D0 (en) 2002-03-08 2002-04-12 Human analogues of murine deubiquitinating protease genes
GB0208404.4 2002-04-12

Publications (2)

Publication Number Publication Date
WO2003072724A2 WO2003072724A2 (fr) 2003-09-04
WO2003072724A3 true WO2003072724A3 (fr) 2005-04-07

Family

ID=27767875

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/005338 WO2003072724A2 (fr) 2002-02-22 2003-02-20 Analogues humains de genes de protease murine liberatrice d'ubiquitine

Country Status (7)

Country Link
EP (1) EP1534825A4 (fr)
AU (1) AU2003215370B2 (fr)
BR (1) BR0307895A (fr)
CA (1) CA2476770A1 (fr)
IL (1) IL163528A0 (fr)
MX (1) MXPA04007760A (fr)
WO (1) WO2003072724A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070129319A1 (en) * 2003-11-14 2007-06-07 The Queen's University Of Belfast Genes encoding human deubiquitinating enzymes
US20090208446A1 (en) * 2006-05-12 2009-08-20 The Queen's University Of Belfast DUB3 as a Cancer Therapy Target

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7357896A (en) * 1995-08-09 1997-03-05 Dana-Farber Cancer Institute Deubiquitinating enzymes that regulate cell growth
AU4818599A (en) * 1998-07-06 2000-01-24 Schering Corporation Mammalian genes; dendritic cell prostaglandin-like transponder (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12),md-1, md2 and cyclin e2, related reagents and methods
US20070129319A1 (en) * 2003-11-14 2007-06-07 The Queen's University Of Belfast Genes encoding human deubiquitinating enzymes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHUNG C.H. ET AL.: "Deubiquitinating enzymes: their diversity and emerging roles", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 266, no. 3, November 1999 (1999-11-01), pages 633 - 640, XP002218428 *
WING S.S.: "Deubiquitinating enzymes - the importance of driving in reverse along the ubiquitin-proteasome pathway", INT. J. BIOCHEM. CELL. BIOL., vol. 35, no. 5, May 2003 (2003-05-01), pages 590 - 605, XP002984879 *

Also Published As

Publication number Publication date
WO2003072724A2 (fr) 2003-09-04
CA2476770A1 (fr) 2003-09-04
AU2003215370A1 (en) 2003-09-09
AU2003215370B2 (en) 2008-06-12
MXPA04007760A (es) 2005-08-15
EP1534825A2 (fr) 2005-06-01
EP1534825A4 (fr) 2006-02-01
BR0307895A (pt) 2006-01-17
IL163528A0 (en) 2005-12-18

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