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WO2003041656A3 - Soluble drug extended release system - Google Patents

Soluble drug extended release system Download PDF

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Publication number
WO2003041656A3
WO2003041656A3 PCT/US2002/036681 US0236681W WO03041656A3 WO 2003041656 A3 WO2003041656 A3 WO 2003041656A3 US 0236681 W US0236681 W US 0236681W WO 03041656 A3 WO03041656 A3 WO 03041656A3
Authority
WO
WIPO (PCT)
Prior art keywords
soluble drug
extended release
release system
drug
novel
Prior art date
Application number
PCT/US2002/036681
Other languages
French (fr)
Other versions
WO2003041656A2 (en
Inventor
Victoria Rogers
Philippe J M Dor
Joseph A Fix
Hiroyuki Kojima
Kazuhiro Sako
Original Assignee
Yamanouchi Pharma Tech Inc
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Tech Inc, Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Tech Inc
Priority to AU2002348279A priority Critical patent/AU2002348279C1/en
Priority to MXPA04004544A priority patent/MXPA04004544A/en
Priority to KR1020107024523A priority patent/KR101132969B1/en
Priority to JP2003543543A priority patent/JP4882200B2/en
Priority to EP02782303A priority patent/EP1443901A4/en
Priority to CA2466657A priority patent/CA2466657C/en
Publication of WO2003041656A2 publication Critical patent/WO2003041656A2/en
Publication of WO2003041656A3 publication Critical patent/WO2003041656A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention relates to novel oral sustained-release formulations for delivery of an active agent (e.g., a drug), especially a highly water soluble drug. More particularly, this invention relates to novel formulations comprising a micelle-forming drug having a charge and at least one polymer having an opposite charge. Methods of using the novel formulations are also provided.
PCT/US2002/036681 2001-11-13 2002-11-12 Soluble drug extended release system WO2003041656A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2002348279A AU2002348279C1 (en) 2001-11-13 2002-11-12 Soluble drug extended release system
MXPA04004544A MXPA04004544A (en) 2001-11-13 2002-11-12 Soluble drug extended release system.
KR1020107024523A KR101132969B1 (en) 2001-11-13 2002-11-12 Soluble drug extended release system
JP2003543543A JP4882200B2 (en) 2001-11-13 2002-11-12 Water-soluble drug sustained release technology
EP02782303A EP1443901A4 (en) 2001-11-13 2002-11-12 Soluble drug extended release system
CA2466657A CA2466657C (en) 2001-11-13 2002-11-12 Soluble drug extended release system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US787701A 2001-11-13 2001-11-13
US10/007,877 2001-11-13

Publications (2)

Publication Number Publication Date
WO2003041656A2 WO2003041656A2 (en) 2003-05-22
WO2003041656A3 true WO2003041656A3 (en) 2003-10-23

Family

ID=21728577

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/036681 WO2003041656A2 (en) 2001-11-13 2002-11-12 Soluble drug extended release system

Country Status (10)

Country Link
EP (1) EP1443901A4 (en)
JP (2) JP4882200B2 (en)
KR (2) KR101132969B1 (en)
CN (1) CN100534531C (en)
AU (1) AU2002348279C1 (en)
CA (1) CA2466657C (en)
MX (1) MXPA04004544A (en)
PL (1) PL374280A1 (en)
RU (1) RU2322263C2 (en)
WO (1) WO2003041656A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050042289A1 (en) * 2003-04-29 2005-02-24 Yamanouchi Pharma Technologies, Inc. Tablets and methods for modified release of hydrophylic and other active agents
JP4822092B2 (en) * 2003-09-01 2011-11-24 大正製薬株式会社 W / O / W type composite emulsion
EP1680098A4 (en) * 2003-11-04 2012-06-13 Supernus Pharmaceuticals Inc Sustained release of positively charged pharmacologically active molecules from a matrix containing polymers with polarized oxygen atoms
US8197846B2 (en) 2003-11-10 2012-06-12 Astellas Pharma Inc. Sustained release pharmaceutical composition
KR100638041B1 (en) * 2003-12-24 2006-10-23 주식회사 삼양사 A nanoparticle composition of a water-soluble drug for oral administration and a preparation method thereof
CN102387792B (en) * 2009-03-25 2013-08-14 琳得科株式会社 Solid preparation
KR101319420B1 (en) * 2011-03-18 2013-10-17 한남대학교 산학협력단 Water-soluble positive-charged drug delivery system with sustained release behavior
EP2696853B1 (en) * 2011-04-11 2019-10-23 Council of Scientific & Industrial Research Surface induced disassembly of nano containers
CN102977413B (en) * 2011-09-07 2015-05-13 江南大学 New method for preparing micelles by compounding polymers
CN103083222B (en) * 2011-10-28 2015-08-19 江南大学 One kettle way prepares three-component polymer micelle
JP6041823B2 (en) 2013-03-16 2016-12-14 ファイザー・インク Tofacitinib oral sustained release dosage form
KR20220022829A (en) * 2020-08-19 2022-02-28 주식회사 모든바이오 A nanoparticle containing glycyrrhizin and water-soluble drug, pharmaceutical composition containing the thereof, and method for preparing the thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219563A (en) * 1988-05-11 1993-06-15 Glaxo Group Limited Drug adsorbates
US5788959A (en) * 1995-04-24 1998-08-04 University Of Maryland, Baltimore County Drug delivery device and method for employing the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE32806B1 (en) * 1968-05-21 1973-12-12 American Home Prod Sustained release drug composition
JPS6410466A (en) * 1987-07-01 1989-01-13 Brother Ind Ltd Data recording and reproducing method for magnetic disk
RO112991B1 (en) * 1992-09-18 1998-03-30 Yamanouchi Pharma Co Ltd Sustained release hydrogel-type preparation
US6221399B1 (en) * 1995-08-17 2001-04-24 Csir Method of making controlled release particles of complexed polymers
IT1297461B1 (en) * 1997-10-29 1999-12-17 Ciocca Maurizio PREPARATION OF CONTROLLED RELEASE TABLETS BASED ON COMPLEXES BETWEEN CARRAGENANO AND SOLUBLE BASIC DRUGS
PL346798A1 (en) * 1998-09-14 2002-02-25 Ranbaxy Lab Ltd Orally administered controlled drug delivery system providing temporal and spatial control
US6287599B1 (en) * 2000-12-20 2001-09-11 Shire Laboratories, Inc. Sustained release pharmaceutical dosage forms with minimized pH dependent dissolution profiles
AR034517A1 (en) * 2001-06-21 2004-02-25 Astrazeneca Ab PHARMACEUTICAL FORMULATION

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219563A (en) * 1988-05-11 1993-06-15 Glaxo Group Limited Drug adsorbates
US5788959A (en) * 1995-04-24 1998-08-04 University Of Maryland, Baltimore County Drug delivery device and method for employing the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1443901A4 *

Also Published As

Publication number Publication date
EP1443901A2 (en) 2004-08-11
KR101132969B1 (en) 2012-04-09
PL374280A1 (en) 2005-10-03
JP4882200B2 (en) 2012-02-22
CN100534531C (en) 2009-09-02
KR20100123779A (en) 2010-11-24
CA2466657C (en) 2011-02-01
WO2003041656A2 (en) 2003-05-22
JP4894958B2 (en) 2012-03-14
KR101016619B1 (en) 2011-02-23
EP1443901A4 (en) 2010-06-16
CA2466657A1 (en) 2003-05-22
MXPA04004544A (en) 2005-03-31
RU2004117848A (en) 2005-05-27
RU2322263C2 (en) 2008-04-20
JP2011068700A (en) 2011-04-07
AU2002348279B2 (en) 2008-01-24
AU2002348279C1 (en) 2008-09-04
JP2005508995A (en) 2005-04-07
CN1612726A (en) 2005-05-04
KR20050044424A (en) 2005-05-12

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