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WO2003040185A3 - Anti-n-glykolyl-neuraminsäure-antikörper und ihre verwendung zur bestimmung von glykoproteinen - Google Patents

Anti-n-glykolyl-neuraminsäure-antikörper und ihre verwendung zur bestimmung von glykoproteinen Download PDF

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Publication number
WO2003040185A3
WO2003040185A3 PCT/EP2002/012579 EP0212579W WO03040185A3 WO 2003040185 A3 WO2003040185 A3 WO 2003040185A3 EP 0212579 W EP0212579 W EP 0212579W WO 03040185 A3 WO03040185 A3 WO 03040185A3
Authority
WO
WIPO (PCT)
Prior art keywords
glycolyl
neuraminic acid
glycoproteins
antibodies
acid antibodies
Prior art date
Application number
PCT/EP2002/012579
Other languages
English (en)
French (fr)
Other versions
WO2003040185A2 (de
Inventor
Rudolf Grimm
Carsten Brockmeyer
Original Assignee
Hexal Biotech Forschungsgmbh
Rudolf Grimm
Carsten Brockmeyer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hexal Biotech Forschungsgmbh, Rudolf Grimm, Carsten Brockmeyer filed Critical Hexal Biotech Forschungsgmbh
Priority to EP02785382A priority Critical patent/EP1442063A2/de
Publication of WO2003040185A2 publication Critical patent/WO2003040185A2/de
Publication of WO2003040185A3 publication Critical patent/WO2003040185A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Die Erfindung betrifft monoklonale Antikörper, welche spezifisch an Glykoproteine binden, die N-Glykanketten mit einer endständigen glykosidisch gebundenen N-Glykolylneuraminsäure umfassen, und Hybridoma-Zellen, die solche Antikörper produzieren. Die Antikörper können in Immunoassays verwendet werden, um beispielsweise rekombinante humane Glykoproteine zu bestimmen.
PCT/EP2002/012579 2001-11-09 2002-11-11 Anti-n-glykolyl-neuraminsäure-antikörper und ihre verwendung zur bestimmung von glykoproteinen WO2003040185A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP02785382A EP1442063A2 (de) 2001-11-09 2002-11-11 Anti-n-glykolyl-neuraminsäure-antikörper und ihre verwendung zur bestimmung von glykoproteinen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10155081 2001-11-09
DE10155081.2 2001-11-09

Publications (2)

Publication Number Publication Date
WO2003040185A2 WO2003040185A2 (de) 2003-05-15
WO2003040185A3 true WO2003040185A3 (de) 2003-09-25

Family

ID=7705189

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/012579 WO2003040185A2 (de) 2001-11-09 2002-11-11 Anti-n-glykolyl-neuraminsäure-antikörper und ihre verwendung zur bestimmung von glykoproteinen

Country Status (2)

Country Link
EP (1) EP1442063A2 (de)
WO (1) WO2003040185A2 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9273142B2 (en) 2012-04-04 2016-03-01 Siamab Therapeutics, Inc. Glycan-interacting compounds
USRE49435E1 (en) 2014-11-12 2023-02-28 Seagen Inc. Glycan-interacting compounds and methods of use

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2302390B1 (de) * 2003-07-15 2013-06-05 The Regents of The University of California Verfahren zur Detektion und Analyse von N-Glykolylneuraminsäure (Neu5Gc) spezifischen Antikörpern in biologischen Materialien
US9879087B2 (en) 2014-11-12 2018-01-30 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
CA3002097A1 (en) 2015-11-12 2017-05-18 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
US11401330B2 (en) 2016-11-17 2022-08-02 Seagen Inc. Glycan-interacting compounds and methods of use
EP3589319A4 (de) 2017-03-03 2021-07-14 Seagen Inc. Glycaninteragierende verbindungen und verfahren zur verwendung

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DEVINE P L ET AL: "THE BREAST TUMOR-ASSOCIATED EPITOPE DEFINED BY MONOCLONAL ANTIBODY 3E1.2 IS AN O-LINKED MUCIN CARBOHYDRATE CONTAINING N GLYCOLYLNEURAMINIC ACID", CANCER RESEARCH, vol. 51, no. 21, 1991, pages 5826 - 5836, XP001121854, ISSN: 0008-5472 *
MORENO E ET AL: "DELINEATION OF THE EPITOPE RECOGNIZED BY AN ANTIBODY SPECIFIC FOR N-GLYCOLYLNEURAMINIC ACID-CONTAINING GANGLIOSIDES", GLYCOBIOLOGY, IRL PRESS,, GB, vol. 8, no. 7, 1998, pages 695 - 705, XP000700252, ISSN: 0959-6658 *
OZAWA H ET AL: "Generation of murine monoclonal antibodies specific for N-glycolylneuraminic acid-containing gangliosides", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, NEW YORK, US, US, vol. 294, no. 2, 1 May 1992 (1992-05-01), pages 427 - 433, XP002102251, ISSN: 0003-9861 *
SHERMAN A A ET AL: "Preparative route to N-glycolylneuraminic acid phenyl 2-thioglycoside donor and synthesis of Neu5Gc-alpha-(2->3')-lactosamine 3-aminopropyl glycoside", CARBOHYDRATE RESEARCH, ELSEVIER SCIENTIFIC PUBLISHING COMPANY. AMSTERDAM, NL, vol. 337, no. 5, 1 March 2002 (2002-03-01), pages 451 - 457, XP004349736, ISSN: 0008-6215 *
SHERMAN A A ET AL: "Synthesis of Neu5Ac- and Neu5Gc-alpha-(2->6')-lactosamine 3-aminopropyl glycosides", CARBOHYDRATE RESEARCH, ELSEVIER SCIENTIFIC PUBLISHING COMPANY. AMSTERDAM, NL, vol. 330, no. 4, 28 February 2001 (2001-02-28), pages 445 - 458, XP004231155, ISSN: 0008-6215 *
USUBA O ET AL: "ESTABLISHMENT OF A HUMAN MONOCLONAL ANTIBODY TO HANGANUTZIU-DEICHER ANTIGEN AS A TUMOR-ASSOCIATED CARBOHYDRATE ANTIGEN", JAPANESE JOURNAL OF CANCER RESEARCH, vol. 79, no. 12, 1988, pages 1340 - 1348, XP009004005, ISSN: 0910-5050 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9273142B2 (en) 2012-04-04 2016-03-01 Siamab Therapeutics, Inc. Glycan-interacting compounds
US9416194B2 (en) 2012-04-04 2016-08-16 Siamab Therapeutics, Inc. Glycan-interacting compounds
USRE49435E1 (en) 2014-11-12 2023-02-28 Seagen Inc. Glycan-interacting compounds and methods of use

Also Published As

Publication number Publication date
EP1442063A2 (de) 2004-08-04
WO2003040185A2 (de) 2003-05-15

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