Nothing Special   »   [go: up one dir, main page]

WO2002006455A3 - Regulation of human airway trypsin protease-like enzyme - Google Patents

Regulation of human airway trypsin protease-like enzyme Download PDF

Info

Publication number
WO2002006455A3
WO2002006455A3 PCT/EP2001/008180 EP0108180W WO0206455A3 WO 2002006455 A3 WO2002006455 A3 WO 2002006455A3 EP 0108180 W EP0108180 W EP 0108180W WO 0206455 A3 WO0206455 A3 WO 0206455A3
Authority
WO
WIPO (PCT)
Prior art keywords
human airway
enzyme
trypsin protease
airway trypsin
regulation
Prior art date
Application number
PCT/EP2001/008180
Other languages
French (fr)
Other versions
WO2002006455A2 (en
Inventor
Yonghong Xiao
Original Assignee
Bayer Ag
Yonghong Xiao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Yonghong Xiao filed Critical Bayer Ag
Priority to AU2001270638A priority Critical patent/AU2001270638A1/en
Publication of WO2002006455A2 publication Critical patent/WO2002006455A2/en
Publication of WO2002006455A3 publication Critical patent/WO2002006455A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reagents which regulate human airway trypsin protease-like enzyme and reagents which bind to human airway trypsin protease-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, chronic obstructive pulmonary disease (COPD). The human airway trypsin protease-like ezyme also is expected to be useful for treating cancer, cardiovascular diseases and central nervous system (CNS) diseases.
PCT/EP2001/008180 2000-07-19 2001-07-16 Regulation of human airway trypsin protease-like enzyme WO2002006455A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001270638A AU2001270638A1 (en) 2000-07-19 2001-07-16 Regulation of human airway trypsin protease-like enzyme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21911000P 2000-07-19 2000-07-19
US60/219,110 2000-07-19

Publications (2)

Publication Number Publication Date
WO2002006455A2 WO2002006455A2 (en) 2002-01-24
WO2002006455A3 true WO2002006455A3 (en) 2002-09-12

Family

ID=22817921

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008180 WO2002006455A2 (en) 2000-07-19 2001-07-16 Regulation of human airway trypsin protease-like enzyme

Country Status (2)

Country Link
AU (1) AU2001270638A1 (en)
WO (1) WO2002006455A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10258051A1 (en) * 2002-12-11 2004-07-22 Metagen Pharmaceuticals Gmbh Use of substances that bind to HAT for the diagnosis and treatment of squamous cell carcinoma of the lungs
GB0507577D0 (en) * 2005-04-14 2005-05-18 Novartis Ag Organic compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0699763B1 (en) * 1994-07-29 1998-09-30 Teijin Limited Nucleic acid sequence encoding trypsin-like enzyme and process for producing the enzyme
WO1999038973A2 (en) * 1998-01-28 1999-08-05 Corixa Corporation Compounds for therapy and diagnosis of lung cancer and methods for their use
WO2001036645A2 (en) * 1999-11-17 2001-05-25 Curagen Corporation Serine/threonine kinase and serine protease polypeptides and nucleic acids encoding same
WO2001057194A2 (en) * 2000-02-03 2001-08-09 Corvas International, Inc. Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
EP1152057A1 (en) * 1999-12-06 2001-11-07 Teijin Limited Antibody binding to human airway trypsin-like enzyme and utilization thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0699763B1 (en) * 1994-07-29 1998-09-30 Teijin Limited Nucleic acid sequence encoding trypsin-like enzyme and process for producing the enzyme
WO1999038973A2 (en) * 1998-01-28 1999-08-05 Corixa Corporation Compounds for therapy and diagnosis of lung cancer and methods for their use
WO2001036645A2 (en) * 1999-11-17 2001-05-25 Curagen Corporation Serine/threonine kinase and serine protease polypeptides and nucleic acids encoding same
EP1152057A1 (en) * 1999-12-06 2001-11-07 Teijin Limited Antibody binding to human airway trypsin-like enzyme and utilization thereof
WO2001057194A2 (en) * 2000-02-03 2001-08-09 Corvas International, Inc. Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DODSON G ET AL: "Catalytic triads and their relatives", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 23, no. 9, 1 September 1998 (1998-09-01), pages 347 - 352, XP004146829, ISSN: 0968-0004 *
YAMAOKA K ET AL: "CLONING AND CHARACTERIZATION OF THE CDNA FOR HUMAN AIRWAY TRYPSIN-LIKE PROTEASE", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 19, 8 May 1998 (1998-05-08), pages 11895 - 11901, XP002917601, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
AU2001270638A1 (en) 2002-01-30
WO2002006455A2 (en) 2002-01-24

Similar Documents

Publication Publication Date Title
WO2002036754A3 (en) Nucleotide and polypeptide sequence of human lysosomal acid lipase
WO2002006455A3 (en) Regulation of human airway trypsin protease-like enzyme
WO2002006453A3 (en) Regulation of human desc1-like serine protease
WO2002010403A3 (en) Regulation of human phosphatidylinositol-specific phospholipase c-like enzyme
WO2002026996A3 (en) Regulation of human phosphatidylinositol-specific phospholipase c-like enzyme
WO2002020732A3 (en) Regulation of human map kinase phosphatase-like enzyme
WO2003052088A3 (en) Regulation of human sialyltransferase
WO2002031160A3 (en) Regulation of human phospholipase a2-like enzyme
WO2002024927A3 (en) Regulation of human adam-ts 1 precursor-like protein
WO2002042435A3 (en) Regulation of human tyrosine phosphatase
WO2002020747A3 (en) Regulation of human tyrosine phosphatase-like enzyme
WO2002031162A3 (en) Regulation of human phospholipase a2-like enzyme
WO2002000704A3 (en) Regulation of human phospholipase c-like enzyme
WO2002048358A3 (en) Regulation of human chemokine-like receptor
WO2002036731A3 (en) Human lysosomal acid lipase
WO2002031161A3 (en) Regulation of human phospholipase-like enzyme
WO2002033056A3 (en) Regulation of human serine-threonine protein kinase
WO2002033095A3 (en) Regulation of human serine-threonine protein kinase
WO2002022791A3 (en) Regulation of human pyridoxine 5'-phosphate oxidase
WO2002031125A3 (en) Human phospholipase a2-like enzyme
WO2002092798A3 (en) Regulation of human phosphatidic acid phosphatase type 2c-like protein
WO2002032938A3 (en) Regulation of human pgc-1-like protein
WO2002020805A3 (en) Regulation of human carboxypeptidase-like enzyme
WO2002018566A3 (en) Regulation of human l-asparaginase-like enzyme
WO2002090543A3 (en) Regulation of human phosphatidic acid phosphatase type 2c-like protein

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP