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WO2002055489A3 - Pim kinase-related methods - Google Patents

Pim kinase-related methods Download PDF

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Publication number
WO2002055489A3
WO2002055489A3 PCT/US2001/050535 US0150535W WO02055489A3 WO 2002055489 A3 WO2002055489 A3 WO 2002055489A3 US 0150535 W US0150535 W US 0150535W WO 02055489 A3 WO02055489 A3 WO 02055489A3
Authority
WO
WIPO (PCT)
Prior art keywords
pim kinase
related methods
subject
present
agent
Prior art date
Application number
PCT/US2001/050535
Other languages
French (fr)
Other versions
WO2002055489A2 (en
Inventor
Paul Rothman
Peter Chen
Original Assignee
The Trustees Of Columbia University In The City Of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of Columbia University In The City Of New York filed Critical The Trustees Of Columbia University In The City Of New York
Priority to AU2002246864A priority Critical patent/AU2002246864A1/en
Priority to US10/250,380 priority patent/US20040109868A1/en
Publication of WO2002055489A2 publication Critical patent/WO2002055489A2/en
Publication of WO2002055489A3 publication Critical patent/WO2002055489A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides methods for treating an allergic response, asthma, and the onset of transplant rejection in a subject. These methods involve administering to the subject an agent which increases the amount and/or the activity of a Pim kinase. The present invention also provides a method for determining whether an agent increases the phosphorylation of a Socs-1 protein by a Pim kinase.
PCT/US2001/050535 2000-12-27 2001-12-27 Pim kinase-related methods WO2002055489A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002246864A AU2002246864A1 (en) 2000-12-27 2001-12-27 Pim kinase-related methods
US10/250,380 US20040109868A1 (en) 2001-12-27 2001-12-27 Pim kinase-related methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25842100P 2000-12-27 2000-12-27
US60/258,421 2000-12-27

Publications (2)

Publication Number Publication Date
WO2002055489A2 WO2002055489A2 (en) 2002-07-18
WO2002055489A3 true WO2002055489A3 (en) 2002-10-03

Family

ID=22980473

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/050535 WO2002055489A2 (en) 2000-12-27 2001-12-27 Pim kinase-related methods

Country Status (2)

Country Link
AU (1) AU2002246864A1 (en)
WO (1) WO2002055489A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0313678D0 (en) 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compounds
GB0313677D0 (en) * 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compound
ES2649156T3 (en) 2013-01-14 2018-01-10 Incyte Holdings Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
CN105051029B (en) 2013-01-15 2018-07-31 因赛特公司 It can be used as the thiazole carboxamides and pyridinecarboxylic amine compounds of PIM kinase inhibitors
WO2015027124A1 (en) 2013-08-23 2015-02-26 Incyte Corporation Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
WO2016010897A1 (en) 2014-07-14 2016-01-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
US9540347B2 (en) 2015-05-29 2017-01-10 Incyte Corporation Pyridineamine compounds useful as Pim kinase inhibitors
AR105967A1 (en) 2015-09-09 2017-11-29 Incyte Corp SALTS OF A PIM QUINASA INHIBITOR
TW201718546A (en) 2015-10-02 2017-06-01 英塞特公司 Heterocyclic compounds useful as PIM kinase inhibitors
AR113922A1 (en) 2017-12-08 2020-07-01 Incyte Corp LOW DOSE COMBINATION THERAPY FOR THE TREATMENT OF MYELOPROLIFERATIVE NEOPLASMS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEN ET AL.: "Pim serine/threonine kinases regulate the stability of Socs-1 protein", PROC. NATL. ACAD. SCI. USA, vol. 99, no. 4, February 2000 (2000-02-01), pages 2175 - 2180, XP002951644 *

Also Published As

Publication number Publication date
WO2002055489A2 (en) 2002-07-18
AU2002246864A1 (en) 2002-07-24

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