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WO2001029020A3 - Neuraminidase inhibitors - Google Patents

Neuraminidase inhibitors Download PDF

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Publication number
WO2001029020A3
WO2001029020A3 PCT/US2000/027090 US0027090W WO0129020A3 WO 2001029020 A3 WO2001029020 A3 WO 2001029020A3 US 0027090 W US0027090 W US 0027090W WO 0129020 A3 WO0129020 A3 WO 0129020A3
Authority
WO
WIPO (PCT)
Prior art keywords
neuraminidase inhibitors
compounds
occupation
enzyme
sites
Prior art date
Application number
PCT/US2000/027090
Other languages
French (fr)
Other versions
WO2001029020A9 (en
WO2001029020A2 (en
Inventor
Kent D Stewart
Dale J Kempf
Larry L Klein
Clarence J Maring
Vincent S Stoll
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to AU20393/01A priority Critical patent/AU2039301A/en
Publication of WO2001029020A2 publication Critical patent/WO2001029020A2/en
Publication of WO2001029020A3 publication Critical patent/WO2001029020A3/en
Publication of WO2001029020A9 publication Critical patent/WO2001029020A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides compounds which are neuraminidase inhibitors characterized by a unique three-dimensional conformation and orientation relative to the Sites of Occupation 1-4 of the enzyme. Also provided are pharmaceutical compositions containing said compounds, as well as methods of using said compounds and compositions.
PCT/US2000/027090 1999-10-19 2000-10-02 Neuraminidase inhibitors WO2001029020A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU20393/01A AU2039301A (en) 1999-10-19 2000-10-02 Neuraminidase inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41975999A 1999-10-19 1999-10-19
US09/419,759 1999-10-19

Publications (3)

Publication Number Publication Date
WO2001029020A2 WO2001029020A2 (en) 2001-04-26
WO2001029020A3 true WO2001029020A3 (en) 2001-12-27
WO2001029020A9 WO2001029020A9 (en) 2002-10-03

Family

ID=23663637

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/027090 WO2001029020A2 (en) 1999-10-19 2000-10-02 Neuraminidase inhibitors

Country Status (2)

Country Link
AU (1) AU2039301A (en)
WO (1) WO2001029020A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2075256A2 (en) 2002-01-14 2009-07-01 William Herman Multispecific binding molecules

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648379A (en) * 1990-04-24 1997-07-15 Biota Scientific Management Pty., Ltd. Derivatives and analogues of 2-deoxy-2,3-didehydro-n-acetyl neuraminic acid and their use as antiviral agents
WO1998007685A1 (en) * 1996-08-23 1998-02-26 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
WO1998017647A1 (en) * 1996-10-21 1998-04-30 Gilead Sciences, Inc. Piperidine compounds
WO1999006369A1 (en) * 1997-08-01 1999-02-11 University Of Florida Neuraminidase inhibitors
WO1999055664A1 (en) * 1998-04-24 1999-11-04 Gilead Sciences, Inc. Preparation of carbocyclic compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648379A (en) * 1990-04-24 1997-07-15 Biota Scientific Management Pty., Ltd. Derivatives and analogues of 2-deoxy-2,3-didehydro-n-acetyl neuraminic acid and their use as antiviral agents
WO1998007685A1 (en) * 1996-08-23 1998-02-26 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
WO1998017647A1 (en) * 1996-10-21 1998-04-30 Gilead Sciences, Inc. Piperidine compounds
WO1999006369A1 (en) * 1997-08-01 1999-02-11 University Of Florida Neuraminidase inhibitors
WO1999055664A1 (en) * 1998-04-24 1999-11-04 Gilead Sciences, Inc. Preparation of carbocyclic compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
G. B. KOK ET. AL.: "A Palladium (II) Mediated Approach to Some Novel C-4 Substituted Neu5Ac2en Derivatives.", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANS. I,, no. 5, 1998, pages 905 - 8, XP000984708 *

Also Published As

Publication number Publication date
WO2001029020A9 (en) 2002-10-03
AU2039301A (en) 2001-04-30
WO2001029020A2 (en) 2001-04-26

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