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WO2001004283A3 - Organic anion transporter genes and proteins - Google Patents

Organic anion transporter genes and proteins Download PDF

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Publication number
WO2001004283A3
WO2001004283A3 PCT/US2000/018980 US0018980W WO0104283A3 WO 2001004283 A3 WO2001004283 A3 WO 2001004283A3 US 0018980 W US0018980 W US 0018980W WO 0104283 A3 WO0104283 A3 WO 0104283A3
Authority
WO
WIPO (PCT)
Prior art keywords
organic anion
polypeptides
human organic
anion transporter
proteins
Prior art date
Application number
PCT/US2000/018980
Other languages
French (fr)
Other versions
WO2001004283A9 (en
WO2001004283A2 (en
Inventor
William Sun
Original Assignee
Mets Asis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mets Asis Therapeutics Inc filed Critical Mets Asis Therapeutics Inc
Priority to AU60898/00A priority Critical patent/AU6089800A/en
Publication of WO2001004283A2 publication Critical patent/WO2001004283A2/en
Publication of WO2001004283A3 publication Critical patent/WO2001004283A3/en
Publication of WO2001004283A9 publication Critical patent/WO2001004283A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

This invention relates to novel human organic anion transporter polypeptides and genes encoding such polypeptides. The invention is directed towards the isolation, characterization and use of human organic anion transporter polypeptides for pharmacological screening of substrates, analogues of substrates, and modulators of human organic anion proteins. This invention also provides cell cultures, which stably contain nucleic acid sequences encoding human organic anion transport polypeptides. Such cell lines are useful for screening compounds in vitro to identify and characterize modulators, inhibitors and substrates of human organic anion transporter polypeptides.
PCT/US2000/018980 1999-07-12 2000-07-12 Organic anion transporter genes and proteins WO2001004283A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU60898/00A AU6089800A (en) 1999-07-12 2000-07-12 Organic anion transporter genes and proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14377199P 1999-07-12 1999-07-12
US60/143,771 1999-07-12

Publications (3)

Publication Number Publication Date
WO2001004283A2 WO2001004283A2 (en) 2001-01-18
WO2001004283A3 true WO2001004283A3 (en) 2001-07-26
WO2001004283A9 WO2001004283A9 (en) 2002-05-02

Family

ID=22505543

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/018980 WO2001004283A2 (en) 1999-07-12 2000-07-12 Organic anion transporter genes and proteins

Country Status (2)

Country Link
AU (1) AU6089800A (en)
WO (1) WO2001004283A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8039586B1 (en) 1998-09-18 2011-10-18 J-Pharma Co., Ltd. Cerebral organic anion transporter and its gene
WO2000052024A1 (en) * 1999-03-04 2000-09-08 Smithkline Beecham Corporation POLYNUCLEOTIDE AND POLYPEPTIDE SEQUENCES ENCODING HUMAN ORGANIC ANION TRANSPORTER 6(hOATP6) AND SCREENING METHODS THEREOF
CA2435828A1 (en) * 2001-01-22 2002-10-10 Pe Corporation (Ny) Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
JP2003265179A (en) * 2002-03-14 2003-09-24 Japan Science & Technology Corp Transporter for selectively transporting sulfate conjugate and its gene
WO2005026734A1 (en) * 2003-09-13 2005-03-24 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with organic cation transporter slc22a6 (slc22a6)
WO2005026726A1 (en) * 2003-09-18 2005-03-24 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with organic cation transporter slc22a7 (slc22a7)
WO2005026725A1 (en) * 2003-09-18 2005-03-24 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with organic antion transporter slc22a8 (slc22a8)
WO2005029086A2 (en) * 2003-09-22 2005-03-31 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with organic cation transporter slc22a10 (ust3-like2) (slc22a10)
WO2007071268A1 (en) * 2005-12-19 2007-06-28 Sca Hygiene Products Ab Multi-configurable absorbent article
JP2009034096A (en) * 2008-06-12 2009-02-19 J-Pharma Co Ltd Transporter selectively transporting sulfate conjugate, and gene of the same
EP2684055A1 (en) * 2011-03-09 2014-01-15 Bayer Intellectual Property GmbH Modulators of slc22a7
PL3461888T3 (en) * 2012-09-11 2020-12-14 Corning Incorporated Consumable cryopreserved cells transiently overexpressing gene(s) encoding drug transporter protein(s) and/or drug metabolizing enzyme(s)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053064A1 (en) * 1997-05-23 1998-11-26 Tanabe Seiyaku Co., Ltd. Organic anion transporter and gene coding for the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053064A1 (en) * 1997-05-23 1998-11-26 Tanabe Seiyaku Co., Ltd. Organic anion transporter and gene coding for the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 18 June 1998 (1998-06-18), ROBERT STRAUSBERG: "similar to TR:Q63314 Q63314 LIVER-SPECIFIC TRANSPORT PROTEIN", XP002156222 *
DATABASE EMBL 7 June 1999 (1999-06-07), KIM R.B. ET AL.: "homo sapiens liver-specific transporter (NLT) mRNA, complete cds.", XP002156221 *
KUSUHARA HIROYUKI ET AL: "Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 19, 7 May 1999 (1999-05-07), pages 13675 - 13680, XP002156219, ISSN: 0021-9258 *
SIMONSON GREGG D ET AL: "Molecular cloning and characterization of a novel liver-specific transport protein.", JOURNAL OF CELL SCIENCE, vol. 107, no. 4, 1994, pages 1065 - 1072, XP000971769, ISSN: 0021-9533 *

Also Published As

Publication number Publication date
AU6089800A (en) 2001-01-30
WO2001004283A9 (en) 2002-05-02
WO2001004283A2 (en) 2001-01-18

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