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WO2001089681A3 - Modular chemical production system incorporating a microreactor - Google Patents

Modular chemical production system incorporating a microreactor Download PDF

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Publication number
WO2001089681A3
WO2001089681A3 PCT/US2001/015738 US0115738W WO0189681A3 WO 2001089681 A3 WO2001089681 A3 WO 2001089681A3 US 0115738 W US0115738 W US 0115738W WO 0189681 A3 WO0189681 A3 WO 0189681A3
Authority
WO
WIPO (PCT)
Prior art keywords
product
modules
produce
microreactor
reactants
Prior art date
Application number
PCT/US2001/015738
Other languages
French (fr)
Other versions
WO2001089681A2 (en
Inventor
Thomas Schwalbe
Sebastian Oberbeck
Klaus Golbig
Michael Hohmann
Andreas Oberbeck
Original Assignee
Cellular Process Chemistry Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/578,224 external-priority patent/US7056477B1/en
Application filed by Cellular Process Chemistry Inc filed Critical Cellular Process Chemistry Inc
Priority to JP2001585914A priority Critical patent/JP2004508919A/en
Priority to EP01935559A priority patent/EP1286761A2/en
Publication of WO2001089681A2 publication Critical patent/WO2001089681A2/en
Publication of WO2001089681A3 publication Critical patent/WO2001089681A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/0081—Plurality of modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00835—Comprising catalytically active material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00867—Microreactors placed in series, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00869—Microreactors placed in parallel, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00871—Modular assembly
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00984—Residence time

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

A modular chemical production system having a microreactor for producing a product by reacting two or more reactants. Modularization enables components such as controllers, pumps, valves, microreactors, and processing modules to be added or removed from the system as required to produce a desired product. The system includes a control module, and a reaction module having a mixing volume and a reaction volume. Various pumping modules and residence time modules may also be included in the system. Quick connect/disconnect fittings enable modules to be readily changed if malfunctioning, or to produce a different product, or quantity. A database includes optimal parameters for a plurality of different reactions yielding different chemical products. The user selects a desired product and amount, provides the reactants, solvents, and heat transfer media supplies, and the control module operates the system to automatically produce the product until the desired amount is obtained.
PCT/US2001/015738 2000-05-24 2001-05-15 Modular chemical production system incorporating a microreactor WO2001089681A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2001585914A JP2004508919A (en) 2000-05-24 2001-05-15 Modular chemical production system incorporating microreactor
EP01935559A EP1286761A2 (en) 2000-05-24 2001-05-15 Modular chemical production system incorporating a microreactor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/578,224 2000-05-24
US09/578,224 US7056477B1 (en) 2000-02-03 2000-05-24 Modular chemical production system incorporating a microreactor

Publications (2)

Publication Number Publication Date
WO2001089681A2 WO2001089681A2 (en) 2001-11-29
WO2001089681A3 true WO2001089681A3 (en) 2003-01-03

Family

ID=24311932

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015738 WO2001089681A2 (en) 2000-05-24 2001-05-15 Modular chemical production system incorporating a microreactor

Country Status (3)

Country Link
EP (1) EP1286761A2 (en)
JP (1) JP2004508919A (en)
WO (1) WO2001089681A2 (en)

Cited By (16)

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US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US8894947B2 (en) 2001-03-28 2014-11-25 Handylab, Inc. Systems and methods for thermal actuation of microfluidic devices
US9028773B2 (en) 2001-09-12 2015-05-12 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US9051604B2 (en) 2001-02-14 2015-06-09 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
USD742027S1 (en) 2011-09-30 2015-10-27 Becton, Dickinson And Company Single piece reagent holder
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9217143B2 (en) 2007-07-13 2015-12-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9222954B2 (en) 2011-09-30 2015-12-29 Becton, Dickinson And Company Unitized reagent strip
US9238223B2 (en) 2007-07-13 2016-01-19 Handylab, Inc. Microfluidic cartridge
US9259735B2 (en) 2001-03-28 2016-02-16 Handylab, Inc. Methods and systems for control of microfluidic devices
US9259734B2 (en) 2007-07-13 2016-02-16 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9347586B2 (en) 2007-07-13 2016-05-24 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US12128405B2 (en) 2006-11-14 2024-10-29 Handylab, Inc. Microfluidic valve and method of making same

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US6969506B2 (en) 1999-08-17 2005-11-29 Battelle Memorial Institute Methods of conducting simultaneous exothermic and endothermic reactions
DE10032059A1 (en) * 2000-07-05 2002-01-17 Mir Chem Gmbh Device for carrying out a catalytic tube reaction
US7071191B2 (en) 2000-08-08 2006-07-04 Ortho-Mcneil Pharmaceutical, Inc. Non-imidazole aryloxypiperidines
BRPI0113162B8 (en) 2000-08-08 2021-05-25 Johnson & Johnson non-imidazole aryloxyalkylamine compounds and pharmaceutical composition comprising said compounds
DE10143189A1 (en) * 2001-09-04 2003-03-20 Clariant Gmbh Method and device for the in-process cleaning of micro and mini reactors
DE20201753U1 (en) 2002-02-05 2002-04-11 Ehrfeld Mikrotechnik GmbH, 55234 Wendelsheim Modular microreactor system
DE10209897A1 (en) * 2002-03-08 2003-09-25 Merck Patent Gmbh Micro Components Connection System
WO2004011134A1 (en) * 2002-07-26 2004-02-05 Avantium International B.V. System for performing a chemical reaction on a plurality of different microreactors
GB0307999D0 (en) * 2003-04-07 2003-05-14 Glaxo Group Ltd A system
US20070077179A1 (en) * 2003-05-09 2007-04-05 Dirk Schmalz Component used in microprocess control
US7731906B2 (en) 2003-07-31 2010-06-08 Handylab, Inc. Processing particle-containing samples
DE102005013915A1 (en) * 2005-03-24 2006-09-28 Siemens Ag Process engineering, in particular micro process engineering plant
KR101004487B1 (en) 2005-09-08 2010-12-31 가시오게산키 가부시키가이샤 Reformer for power supply of a portable electronic device
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
EP3088083B1 (en) 2006-03-24 2018-08-01 Handylab, Inc. Method of performing pcr with a mult-ilane cartridge
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
TW200738328A (en) 2006-03-31 2007-10-16 Lonza Ag Micro-reactor system assembly
EP2167233B1 (en) * 2007-06-26 2013-01-23 Micronit Microfluidics B.V. Device and method for fluidic coupling of fluidic conduits to a microfluidic chip, and uncoupling thereof
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
WO2009092392A1 (en) * 2008-01-22 2009-07-30 Siemens Aktiengesellschaft Process module for performing a prescribed processing function
DE102008041950A1 (en) 2008-09-10 2010-03-11 Evonik Degussa Gmbh System for providing a universal infrastructure for chemical processes
EP2223741A1 (en) * 2009-02-13 2010-09-01 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Micro fluidic system, including a stack of process modules and heat exchange modules
JP4904374B2 (en) * 2009-03-30 2012-03-28 東レエンジニアリング株式会社 Microreactor
TW201114481A (en) 2009-05-11 2011-05-01 Corning Inc Modular reactor and system
DE202009017416U1 (en) 2009-05-12 2010-04-15 Lonza Ag Reactor and set of reactors
DE202010000262U1 (en) 2009-05-12 2010-05-20 Lonza Ag Flow reactor with microchannel system
CN102803948B (en) 2009-06-09 2015-11-25 通用电气健康护理生物科学股份公司 Robotization fluid handling system
EP3709025A1 (en) 2011-04-15 2020-09-16 Becton, Dickinson and Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
DK2810080T3 (en) 2012-02-03 2024-06-17 Becton Dickinson Co External files for distribution of molecular diagnostic tests and determination of compatibility between tests
WO2016025803A1 (en) 2014-08-15 2016-02-18 Massachusetts Institute Of Technology Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients
US11185839B2 (en) 2016-05-02 2021-11-30 Massachusetts Institute Of Technology Reconfigurable multi-step chemical synthesis system and related components and methods
WO2018200236A1 (en) 2017-04-26 2018-11-01 Massachusetts Institute Of Technology Reconfigurable chemical synthesis systems and methods

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Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9528142B2 (en) 2001-02-14 2016-12-27 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US9051604B2 (en) 2001-02-14 2015-06-09 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US8894947B2 (en) 2001-03-28 2014-11-25 Handylab, Inc. Systems and methods for thermal actuation of microfluidic devices
US9259735B2 (en) 2001-03-28 2016-02-16 Handylab, Inc. Methods and systems for control of microfluidic devices
US9028773B2 (en) 2001-09-12 2015-05-12 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US12128405B2 (en) 2006-11-14 2024-10-29 Handylab, Inc. Microfluidic valve and method of making same
US11845081B2 (en) 2007-07-13 2023-12-19 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9238223B2 (en) 2007-07-13 2016-01-19 Handylab, Inc. Microfluidic cartridge
US9259734B2 (en) 2007-07-13 2016-02-16 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9347586B2 (en) 2007-07-13 2016-05-24 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US12128402B2 (en) 2007-07-13 2024-10-29 Handylab, Inc. Microfluidic cartridge
US9217143B2 (en) 2007-07-13 2015-12-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US9480983B2 (en) 2011-09-30 2016-11-01 Becton, Dickinson And Company Unitized reagent strip
USD742027S1 (en) 2011-09-30 2015-10-27 Becton, Dickinson And Company Single piece reagent holder
US9222954B2 (en) 2011-09-30 2015-12-29 Becton, Dickinson And Company Unitized reagent strip

Also Published As

Publication number Publication date
WO2001089681A2 (en) 2001-11-29
JP2004508919A (en) 2004-03-25
EP1286761A2 (en) 2003-03-05

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