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WO2001046412A3 - Interaktionsprotein für stat transkriptionsfaktor - Google Patents

Interaktionsprotein für stat transkriptionsfaktor Download PDF

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Publication number
WO2001046412A3
WO2001046412A3 PCT/DE2000/004557 DE0004557W WO0146412A3 WO 2001046412 A3 WO2001046412 A3 WO 2001046412A3 DE 0004557 W DE0004557 W DE 0004557W WO 0146412 A3 WO0146412 A3 WO 0146412A3
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
transcription factor
relates
stat transcription
interaction
Prior art date
Application number
PCT/DE2000/004557
Other languages
English (en)
French (fr)
Other versions
WO2001046412A2 (de
Inventor
Renate Weber-Nordt
Angelika Gabler
Original Assignee
Univ Ruprecht Karls Heidelberg
Weber Nordt Renate
Angelika Gabler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ruprecht Karls Heidelberg, Weber Nordt Renate, Angelika Gabler filed Critical Univ Ruprecht Karls Heidelberg
Priority to AU33593/01A priority Critical patent/AU3359301A/en
Publication of WO2001046412A2 publication Critical patent/WO2001046412A2/de
Publication of WO2001046412A3 publication Critical patent/WO2001046412A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Die Erfindung betrifft isolierte Polypeptide, die als Interaktionsprotein des STAT Transkriptionsfaktors STAT3 fungieren und die entweder die im Sequenzprotokoll SEQ ID NO: 2 dargestellte oder eine durch Aminosäuresubstitution, -deletion, -insertion, oder -inversion als Allel oder Derivat daraus entstandene Aminosaüresequenz aufweisen. Sie betrifft ferner isolierte Nukleinsäuren, die solche Interaktionsproteine oder zumindest Teile davon kodieren, die Verwendung solcher Polypeptide und Nukleinsäuren für nachweisende, insbesondere diagnostische, therapeutische und Forschungszwecke und sie betrifft Reagenzien, die unter Verwendung wenigstens eines dieser Moleküle hergestellt sind, insbesondere rekombinante Vektormoleküle und Antikörper.
PCT/DE2000/004557 1999-12-21 2000-12-19 Interaktionsprotein für stat transkriptionsfaktor WO2001046412A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33593/01A AU3359301A (en) 1999-12-21 2000-12-19 Interaction proteins for the stat transcription factor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19961899.2 1999-12-21
DE1999161899 DE19961899A1 (de) 1999-12-21 1999-12-21 Interaktikonsproteine für STAT Transkriptionsfaktor

Publications (2)

Publication Number Publication Date
WO2001046412A2 WO2001046412A2 (de) 2001-06-28
WO2001046412A3 true WO2001046412A3 (de) 2002-03-14

Family

ID=7933731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2000/004557 WO2001046412A2 (de) 1999-12-21 2000-12-19 Interaktionsprotein für stat transkriptionsfaktor

Country Status (3)

Country Link
AU (1) AU3359301A (de)
DE (1) DE19961899A1 (de)
WO (1) WO2001046412A2 (de)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030688A1 (fr) * 1997-01-10 1998-07-16 Tadamitsu Kishimoto Nouvelle proteine de regulation de la fonction stat

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3115599A (en) * 1998-03-27 1999-10-18 Temple University - Of The Commonwealth System Of Higher Education Methods for cancer prognosis and screening antiproliferative agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030688A1 (fr) * 1997-01-10 1998-07-16 Tadamitsu Kishimoto Nouvelle proteine de regulation de la fonction stat
EP0989186A1 (de) * 1997-01-10 2000-03-29 Kishimoto, Tadami Neues protein, welches die funktion von stat reguliert

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHIEN C-T ET AL: "THE TWO-HYBRID SYSTEM: A METHOD TO IDENTIFY AND CLONE GENES FOR PROTEINS THAT INTERACT WITH A PROTEIN OF INTEREST", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 88, 1 November 1991 (1991-11-01), pages 9578 - 9582, XP000647704, ISSN: 0027-8424 *
FRANK DAVID A: "STAT signaling in the pathogenesis and treatment of cancer.", MOLECULAR MEDICINE (NEW YORK), vol. 5, no. 7, July 1999 (1999-07-01), pages 432 - 456, XP001021603, ISSN: 1076-1551 *
GABLER ANGELIKA ET AL: "C102: A novel STAT3 interacting protein.", BLOOD, vol. 96, no. 11 Part 1, 16 November 2000 (2000-11-16), 42nd Annual Meeting of the American Society of Hematology;San Francisco, California, USA; December 01-05, 2000, pages 94a, XP001025916, ISSN: 0006-4971 *
NAKA T ET AL: "NEGATIVE REGULATION OF CYTOKINE SIGNALING: STAT-INDUCED STAT INHIBITOR", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 24, no. 10, October 1999 (1999-10-01), pages 394 - 398, XP001019044, ISSN: 0968-0004 *
NAKA T ET AL: "Structure and function of a new STAT-induced STAT inhibitor", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 387, no. 6636, 26 June 1997 (1997-06-26), pages 924 - 929, XP002088455, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
WO2001046412A2 (de) 2001-06-28
AU3359301A (en) 2001-07-03
DE19961899A1 (de) 2001-07-12

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