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WO1999061911A3 - Nanometer particles containing a reactive monolayer - Google Patents

Nanometer particles containing a reactive monolayer Download PDF

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Publication number
WO1999061911A3
WO1999061911A3 PCT/US1999/007823 US9907823W WO9961911A3 WO 1999061911 A3 WO1999061911 A3 WO 1999061911A3 US 9907823 W US9907823 W US 9907823W WO 9961911 A3 WO9961911 A3 WO 9961911A3
Authority
WO
WIPO (PCT)
Prior art keywords
monolayer
nanometer
core
sized particle
particles containing
Prior art date
Application number
PCT/US1999/007823
Other languages
French (fr)
Other versions
WO1999061911A2 (en
Inventor
Royce W Murray
Allen C Templeton
Michael J Hostetler
Jeremy J Pietron
Original Assignee
Univ North Carolina
Royce W Murray
Allen C Templeton
Michael J Hostetler
Jeremy J Pietron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina, Royce W Murray, Allen C Templeton, Michael J Hostetler, Jeremy J Pietron filed Critical Univ North Carolina
Priority to EP99953384A priority Critical patent/EP1073902A2/en
Priority to CA002329859A priority patent/CA2329859A1/en
Priority to AU60169/99A priority patent/AU6016999A/en
Publication of WO1999061911A2 publication Critical patent/WO1999061911A2/en
Publication of WO1999061911A3 publication Critical patent/WO1999061911A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0043—Preparation of sols containing elemental metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Powder Metallurgy (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

A nanometer-sized particle comprises a core comprising at least one metal or metal alloy; and a monolayer chemically bonded to the core. The monolayer contains at least one reactive substituent which is coupled to a functional material such that the monolayer is chemically modified. A method of making a functionalized nanometer-sized particle comprises providing a nanometer-sized particle comprising a core which comprises at least one metal or metal alloy, and a monolayer adsorbed onto the core wherein the monolayer includes at least one reactive substituent; and coupling the nanometer-sized particle with a functional material such that the monolayer is chemically modified.
PCT/US1999/007823 1998-04-20 1999-04-09 Nanometer particles containing a reactive monolayer WO1999061911A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99953384A EP1073902A2 (en) 1998-04-20 1999-04-09 Nanometer particles containing a reactive monolayer
CA002329859A CA2329859A1 (en) 1998-04-20 1999-04-09 Nanometer particles containing a reactive monolayer
AU60169/99A AU6016999A (en) 1998-04-20 1999-04-09 Nanometer sized particles containing a reactive monolayer adsorbed thereon and methods of making the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6286398A 1998-04-20 1998-04-20
US09/062,863 1998-04-20

Publications (2)

Publication Number Publication Date
WO1999061911A2 WO1999061911A2 (en) 1999-12-02
WO1999061911A3 true WO1999061911A3 (en) 2000-03-09

Family

ID=22045338

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/007823 WO1999061911A2 (en) 1998-04-20 1999-04-09 Nanometer particles containing a reactive monolayer

Country Status (4)

Country Link
EP (1) EP1073902A2 (en)
AU (1) AU6016999A (en)
CA (1) CA2329859A1 (en)
WO (1) WO1999061911A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0025414D0 (en) 2000-10-16 2000-11-29 Consejo Superior Investigacion Nanoparticles
US6483125B1 (en) 2001-07-13 2002-11-19 North Carolina State University Single electron transistors in which the thickness of an insulating layer defines spacing between electrodes
US6653653B2 (en) 2001-07-13 2003-11-25 Quantum Logic Devices, Inc. Single-electron transistors and fabrication methods in which a projecting feature defines spacing between electrodes
GB0126236D0 (en) 2001-11-01 2002-01-02 Univ East Anglia Photosensitiser functionalised nanoparticles
US6673717B1 (en) 2002-06-26 2004-01-06 Quantum Logic Devices, Inc. Methods for fabricating nanopores for single-electron devices
GB0313259D0 (en) * 2003-06-09 2003-07-16 Consejo Superior Investigacion Magnetic nanoparticles
FR2859117B1 (en) 2003-08-27 2006-02-03 Commissariat Energie Atomique USE OF NANOPARTICLES WITH A METAL HEART AND DOUBLE ORGANIC COATING AS CATALYSTS AND NANOPARTICLES USEFUL AS CATALYSTS
US9079765B2 (en) * 2004-10-01 2015-07-14 Midatech Ltd. Nanoparticles comprising antigens and adjuvants, and immunogenic structures
US7824466B2 (en) 2005-01-14 2010-11-02 Cabot Corporation Production of metal nanoparticles
CN1305977C (en) * 2005-03-04 2007-03-21 北京化工大学 Method for modifying the surface of nano inorganic particles by transfer method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0426300A1 (en) * 1989-09-29 1991-05-08 Ortho Diagnostic Systems Inc. Method of producing a reagent containing a narrow distribution of colloidal particles of a selected size and the use thereof
EP0428412A2 (en) * 1989-11-16 1991-05-22 Ortho Diagnostic Systems Inc. Method of producing a metal sol reagent containing colloidal metal particles of a preselected size

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0426300A1 (en) * 1989-09-29 1991-05-08 Ortho Diagnostic Systems Inc. Method of producing a reagent containing a narrow distribution of colloidal particles of a selected size and the use thereof
EP0428412A2 (en) * 1989-11-16 1991-05-22 Ortho Diagnostic Systems Inc. Method of producing a metal sol reagent containing colloidal metal particles of a preselected size

Also Published As

Publication number Publication date
CA2329859A1 (en) 1999-12-02
WO1999061911A2 (en) 1999-12-02
EP1073902A2 (en) 2001-02-07
AU6016999A (en) 1999-12-13

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