WO1997044672B1 - Portable modular blood analyzer with simplified fluid handling sequence - Google Patents
Portable modular blood analyzer with simplified fluid handling sequenceInfo
- Publication number
- WO1997044672B1 WO1997044672B1 PCT/US1997/008737 US9708737W WO9744672B1 WO 1997044672 B1 WO1997044672 B1 WO 1997044672B1 US 9708737 W US9708737 W US 9708737W WO 9744672 B1 WO9744672 B1 WO 9744672B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- analyzer
- blood
- cartridge
- sensor cartridge
- calibrant
- Prior art date
Links
- 210000004369 Blood Anatomy 0.000 title claims abstract 55
- 239000008280 blood Substances 0.000 title claims abstract 55
- 239000012530 fluid Substances 0.000 title claims abstract 21
- 239000002699 waste material Substances 0.000 claims abstract 11
- 238000011010 flushing procedure Methods 0.000 claims abstract 4
- 230000002572 peristaltic Effects 0.000 claims abstract 4
- 239000012491 analyte Substances 0.000 claims 8
- 238000005086 pumping Methods 0.000 claims 3
- 230000002457 bidirectional Effects 0.000 claims 2
- 238000004590 computer program Methods 0.000 claims 1
- 239000010836 blood and blood product Substances 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
Abstract
A portable, modular blood analyzer capable of analyzing multiple blood values in an inexpensive, relatively simple, easy-to-use and easy-to-maintain instrument. The invention comprises a three-part system including an analyzer body (10), calibrant cartridge (14), and sensor cartridge (12). A modular calibrant cartridge (14) is insertable into the analyzer body (10), and contains all necessary calibrant fluids as well as a waste container. A modular sensor cartridge (12) having integral pump tubing (16) plugs into the analyzer body (10) for easy removal and replacement of the sensor elements. The analyzer body (10) internally has modular units including an electronics module, a display module, and a fluidics/printer module. The analyzer uses a single pump head (18) to aspirate blood only to a sensor array within the sensor cartridge (12). This action is accomplished by aspirating blood by rotationg a peristaltic pump (18) in one direction during a first portion of an analysis cycle, and by reversing the pump (18) and flushing the blood from the sensor cartridge (12) with fluid pumped from the opposite direction during a second portion of an analysis cycle. Accordingly, blood contacts only a small portion of the analyzer mechanism, most of which is disposable. Because all valves are 'downstream' from the single pump, no blood products pass through any valves. The analyzer fluid handling section is easily cleaned by removal of the sensor cartridge (12), yielding a single tube pathway. A short path length for blood travel permits using blood samples as small as 200 νl. The analyzer is light and modular in design and is fully automatic.
Claims
AMENDED CLAIMS
[received by the International Bureau on 11 November 1997 (11.11.97); original claims 7, 8, 14 and 16 amended; new claims 18-23 added; remaining claims unchanged (7 pages)]
2. The blood analyzer of claim 1 , further including, internal to the analyzer body, an electronics module embodying control circuitry for receiving input signals from the removable sensor cartridge, for generating at least one analysis of at least one analyte value of a blood sample, for outputting the results of each such analysis, and for controlling the operation of the blood analyzer.
3. The blood analyzer of claim 1 , further including a display module attached to the analyzer body, for displaying results of each such analysis.
4. The blood analyzer of claim 1. further including a printer module internal to the analyzer body, for printing results of each such analysis.
5. The blood analyzer of claim 1 , wherein the blood analyzer with attached removable calibrant cartridge and removable sensor cartridge, weighs less than about 20 pounds.
6. The blood analyzer of claim 1 , wherein the blood analyzer with attached removable calibrant cartridge and removable sensor cartridge, measures less than about 12"W x 12"D * 12"H.
7. The blood analyzer of claim 1 , wherein the calibrant cartridge includes a latching mechanism to maintain a gas-tight fit with the analyzer body when the calibrant cartridge is attached to the analyzer body.
8. A portable, modular blood analyzer capable of analyzing at least one analyte value of a blood sample, comprising:
(a) an analyzer body including analyte determination circuitry;
(b) a removable calibrant cartridge having at least one calibrant fluid container having calibrant fluid for performing at least one analysis of at least one analyte value of a blood sample, and having at least one waste container, the removable calibrant cartridge being configured to attach to the analyzer body without tools;
(c) a removable sensor cartridge having integral pump tubing, the sensor cartridge including at least one sensor for performing at least one analysis of at least one analyte value of a blood sample, the removable sensor cartridge being configured to attach to the analyzer body without tools, and, when so attached, to be in fluid communication with each calibrant fluid container and the waste container and in signal communication with the analyte determination circuitry;
(d) at least one valve situated to alternatively couple the sensor cartridge to a waste port and to at least one calibrant fluid container within the calibrant cartridge;
(e) a sample port, in fluid communication with the sensor cartridge, for drawing a blood sample into the sensor cartridge;
(f) a bidirectional pumping mechanism having a pump head and positioned between the sensor cartridge and each valve, for engaging the pump tubing of the sensor cartridge, and for selectively pumping in a direction towards the waste port and in a direction towards the sample port; wherein the blood analyzer is automatically operated to:
(g) switch each valve to couple the sensor cartridge to the waste port;
(h) actuate the bidirectional pumping mechanism to pump in a direction towards the waste port; (i) draw a blood sample into the sensor cartridge through the sample port; (j) sense desired analyte values of the blood sample within the sensor cartridge; (k) switch each valve to couple the sensor cartridge to one of the calibrant fluid containers within the calibrant cartridge; (1) reverse each pump to pump fluid from the calibrant fluid container in a direction towards the sample port, thereby flushing the blood sample from the sensor cartridge and sample port.
9. The blood analyzer of claim 8, further including, internal to the analyzer body, an electronics module embodying control circuitry for receiving input signals from the removable sensor cartridge, for generating at least one analysis of at least one analyte value of a blood sample, for outputting the results of each such analysis, and for controlling the operation of the blood analyzer.
10. The blood analyzer of claim 8, further including a display module attached to the analyzer body, for displaying results of each such analysis.
1 1. The blood analyzer of claim 8, further including a printer module internal to the analyzer body, for printing results of each such analysis.
12. The blood analyzer of claim 8, wherein the blood analyzer with attached removable calibrant cartridge and removable sensor cartridge, weighs less than about 20 pounds.
13. The blood analyzer of claim 8, wherein the blood analyzer with attached removable calibrant cartridge and removable sensor cartridge, measures less than about 12"W χ 12"D * 12"H.
14. The blood analyzer of claim 8, wherein the calibrant cartridge includes a latching mechanism to maintain a gas-tight fit with the analyzer body when the calibrant cartridge is attached to the analyzer body.
15. A method of processing a sample within a blood analyzer, comprising the steps of:
(a) switching at least one valve to couple a sensor cartridge to a waste port;
(b) actuating at least one pump, positioned between the sensor cartridge and each valve, to pump in a direction towards the waste port;
(c) drawing a blood sample into the sensor cartridge blood analyzer via a sample port;
(d) sensing desired components of the blood sample within the sensor cartridge; (e) switching each valve to couple the sensor cartridge to a fluid source;
(f) reversing each pump to pump fluid from the fluid source in a direction towards the sample port, thereby flushing the blood sample from the sensor cartridge and sample port with fluid.
16. The method of claim 15, wherein substantially no amount of the blood sample is pumped past any valve.
17. A computer program, residing on a computer-readable medium, to implement a method of processing a sample within a blood analyzer, comprising instructions for causing a computer to:
(a) switch at least one valve to couple a sensor cartridge to a waste port; (b) actuate at least one pump, positioned between the sensor cartridge and each valve, to pump in a direction towards the waste port;
(c) draw a blood sample into the sensor cartridge blood analyzer via a sample port;
(d) sense desired components of the blood sample within the sensor cartridge;
(e) switch each valve to couple the sensor cartridge to a fluid source;
(f) reverse each pump to pump fluid from the fluid source in a direction towards the sample port, thereby flushing the blood sample from the sensor cartridge and sample port with fluid.
18. The blood analyzer of claim 1, wherein the sensor cartridge is insertable into a front of the analyzer with the pump head accessible from the front of the analyzer.
19. The blood analyzer of claim 1 , wherein the integral pump tubing of the sensor cartridge has two ends and is mounted to the cartridge at both ends.
20. The blood analyzer of claim 19, wherein the integral pump tubing is stretched around the pump head in peristaltic engagement.
21. The blood analyzer of claim 1 , wherein the integral pump tubing is visible to an operator of the analyzer while in peristaltic engagement with the pump head.
22. The blood analyzer of claim 3, wherein the integral pump tubing and display module are simultaneously viewable by an operator when the tubing is in peristaltic engagement with the pump head. 97/44672 PC17US97/08737
-27-
23. The blood analyzer of claim 22, wherein the integral pump tubing of the sensor cartridge has two ends and is mounted to the cartridge at both said ends.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU30767/97A AU3076797A (en) | 1996-05-20 | 1997-05-20 | Portable modular blood analyzer with simplified fluid handling sequence |
| EP97925710A EP0990158A4 (en) | 1996-05-20 | 1997-05-20 | Portable modular blood analyzer with simplified fluid handling sequence |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/650,341 US5980830A (en) | 1996-05-20 | 1996-05-20 | Portable modular blood analyzer with simplified fluid handling sequence |
| US08/650,341 | 1996-05-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1997044672A1 WO1997044672A1 (en) | 1997-11-27 |
| WO1997044672B1 true WO1997044672B1 (en) | 1997-12-31 |
Family
ID=24608498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/008737 WO1997044672A1 (en) | 1996-05-20 | 1997-05-20 | Portable modular blood analyzer with simplified fluid handling sequence |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US5980830A (en) |
| EP (1) | EP0990158A4 (en) |
| AU (1) | AU3076797A (en) |
| WO (1) | WO1997044672A1 (en) |
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- 1996-05-20 US US08/650,341 patent/US5980830A/en not_active Expired - Lifetime
-
1997
- 1997-05-20 EP EP97925710A patent/EP0990158A4/en not_active Withdrawn
- 1997-05-20 WO PCT/US1997/008737 patent/WO1997044672A1/en not_active Application Discontinuation
- 1997-05-20 AU AU30767/97A patent/AU3076797A/en not_active Abandoned
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