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UY26329A1 - Antagonistas de los receptores de vitronectina - Google Patents

Antagonistas de los receptores de vitronectina

Info

Publication number
UY26329A1
UY26329A1 UY26329A UY26329A UY26329A1 UY 26329 A1 UY26329 A1 UY 26329A1 UY 26329 A UY26329 A UY 26329A UY 26329 A UY26329 A UY 26329A UY 26329 A1 UY26329 A1 UY 26329A1
Authority
UY
Uruguay
Prior art keywords
receptor antagonists
vitronectin receptor
vitronectin
het
osteoporosis
Prior art date
Application number
UY26329A
Other languages
English (en)
Inventor
Peter J Manley
William H Miller
Irene N Uzinskas
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of UY26329A1 publication Critical patent/UY26329A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • External Artificial Organs (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describen compuestos de fórmula (I) que son antagonistas de los receptores de vitronectina y son útiles en el tratamiento de osteoporosis: en los que: R 1 es Het- o Ar, R 2 es o una de sus sales farmacéuticamente aceptables.
UY26329A 1999-09-07 2000-09-06 Antagonistas de los receptores de vitronectina UY26329A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15278099P 1999-09-07 1999-09-07

Publications (1)

Publication Number Publication Date
UY26329A1 true UY26329A1 (es) 2001-07-31

Family

ID=22544416

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26329A UY26329A1 (es) 1999-09-07 2000-09-06 Antagonistas de los receptores de vitronectina

Country Status (29)

Country Link
EP (1) EP1218005B1 (es)
JP (1) JP4685307B2 (es)
KR (1) KR100711170B1 (es)
CN (1) CN1236767C (es)
AR (1) AR025589A1 (es)
AT (1) ATE284870T1 (es)
AU (1) AU768918B2 (es)
BR (1) BR0013749A (es)
CA (1) CA2384671A1 (es)
CO (1) CO5200845A1 (es)
CZ (1) CZ2002822A3 (es)
DE (1) DE60016769T2 (es)
EG (1) EG24179A (es)
ES (1) ES2234658T3 (es)
GC (1) GC0000203A (es)
HK (1) HK1049110B (es)
HU (1) HUP0202710A3 (es)
IL (2) IL148325A0 (es)
MX (1) MXPA02002455A (es)
NO (1) NO322109B1 (es)
NZ (1) NZ517296A (es)
PE (1) PE20010582A1 (es)
PL (1) PL200404B1 (es)
PT (1) PT1218005E (es)
TR (1) TR200200614T2 (es)
TW (1) TWI255813B (es)
UY (1) UY26329A1 (es)
WO (1) WO2001017959A2 (es)
ZA (1) ZA200201780B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6531494B1 (en) 2001-08-29 2003-03-11 Pharmacia Corporation Gem-substituted αvβ3 antagonists
US6982263B2 (en) 2001-06-08 2006-01-03 Boehringer Ingelheim Pharmaceuticals, Inc. Nitriles useful as reversible inhibitors of cysteine proteases
GB0315509D0 (en) 2003-07-02 2003-08-06 Meridica Ltd Dispensing device
US7678810B2 (en) * 2004-03-05 2010-03-16 Taisho Pharmaceutical Co., Ltd Thiazole derivative
CU24147B1 (es) 2010-07-14 2016-02-29 Novartis Ag Compuestos heterociclícos agonistas del receptor ip
US8937069B2 (en) 2012-01-13 2015-01-20 Novartis Ag Substituted pyrrolo[2,3-B]pyrazine compounds and their use
EP2956455B1 (en) 2013-02-13 2017-05-17 Novartis AG Ip receptor agonist heterocyclic compounds
CN108675954A (zh) * 2018-04-03 2018-10-19 爱斯特（成都）生物制药股份有限公司 2-氨基-3-羟甲基吡啶的一种制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325264A (ja) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd 新規２−芳香環置換−３−フェニルプロピオン酸またはアクリル酸誘導体
JPH08325263A (ja) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd 新規２−アミノ−３−フェニルプロピオン酸誘導体
KR19990076876A (ko) * 1995-12-29 1999-10-25 스티븐 베네티아너 비트로넥틴 수용체 길항제
AU8750298A (en) * 1997-08-28 1999-03-22 Ono Pharmaceutical Co. Ltd. Peroxisome proliferator-activated receptor controllers
PE122699A1 (es) * 1997-09-19 2000-02-12 Smithkline Beecham Corp Antagonistas de receptores de vitronectina
TR200002625T2 (tr) * 1998-03-10 2000-12-21 Smithkline Beecham Corporation Vitronektin Reseptörü Antagonistleri
EP1105389A4 (en) * 1998-08-13 2001-10-17 Merck & Co Inc INTEGRIN RECEPTOR ANTAGONISTS

Also Published As

Publication number Publication date
GC0000203A (en) 2006-03-29
IL148325A0 (en) 2002-09-12
EP1218005B1 (en) 2004-12-15
CA2384671A1 (en) 2001-03-15
TWI255813B (en) 2006-06-01
WO2001017959A3 (en) 2001-05-10
PT1218005E (pt) 2005-05-31
ATE284870T1 (de) 2005-01-15
NO20021113D0 (no) 2002-03-06
NZ517296A (en) 2003-11-28
IL148325A (en) 2007-06-03
MXPA02002455A (es) 2002-07-02
JP2003508516A (ja) 2003-03-04
DE60016769T2 (de) 2005-11-24
CO5200845A1 (es) 2002-09-27
KR100711170B1 (ko) 2007-04-27
ZA200201780B (en) 2003-05-28
WO2001017959A2 (en) 2001-03-15
CZ2002822A3 (cs) 2002-07-17
NO20021113L (no) 2002-05-03
BR0013749A (pt) 2003-06-10
AU7354300A (en) 2001-04-10
CN1236767C (zh) 2006-01-18
HK1049110A1 (en) 2003-05-02
NO322109B1 (no) 2006-08-14
DE60016769D1 (de) 2005-01-20
PL200404B1 (pl) 2009-01-30
EG24179A (en) 2008-09-28
AR025589A1 (es) 2002-12-04
EP1218005A4 (en) 2002-10-09
CN1377269A (zh) 2002-10-30
AU768918B2 (en) 2004-01-08
ES2234658T3 (es) 2005-07-01
JP4685307B2 (ja) 2011-05-18
KR20020027624A (ko) 2002-04-13
HUP0202710A2 (hu) 2002-12-28
HK1049110B (zh) 2005-07-22
PL354176A1 (en) 2003-12-29
EP1218005A2 (en) 2002-07-03
TR200200614T2 (tr) 2002-07-22
PE20010582A1 (es) 2001-06-23
HUP0202710A3 (en) 2003-06-30

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20110104