US4968306A - Intravascular catheter having an adjustable length infusion section to delivery therapeutic fluid - Google Patents
Intravascular catheter having an adjustable length infusion section to delivery therapeutic fluid Download PDFInfo
- Publication number
- US4968306A US4968306A US07/377,243 US37724389A US4968306A US 4968306 A US4968306 A US 4968306A US 37724389 A US37724389 A US 37724389A US 4968306 A US4968306 A US 4968306A
- Authority
- US
- United States
- Prior art keywords
- catheter
- infusion section
- outer tubular
- passageways
- fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
- A61B2017/22084—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance stone- or thrombus-dissolving
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M2025/0175—Introducing, guiding, advancing, emplacing or holding catheters having telescopic features, interengaging nestable members movable in relations to one another
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0074—Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
- A61M25/0075—Valve means
Definitions
- This invention generally relates to a vascular catheter which delivers therapeutic fluid to a desired location within a patient's vasculature.
- Therapeutic fluids such as those containing urokinase, streptokinase, tissue plasminogen activator (TPA) have been found effective in many instances in the treatment of vascular thrombosis.
- TPA tissue plasminogen activator
- the systemic administration of such therapeutic agents is not always desirable because the entire body of the patient must be medicated in order to treat small vascular sites. Delivery of therapeutic fluids through vascular catheters directly to a desired treatment site is usually more effective and, moreover, with direct delivery higher concentrations of the therapeutic agent may be used in the treating solution.
- a catheter delivery system which can deliver therapeutic fluids to one or more thrombotic sites with means to adjust the effective length of drug delivery section of the catheter body, particularly after the catheter has been inserted into the patient's blood vessels.
- the present invention provides a catheter which satisfies this need.
- the present invention is directed to a catheter for the intravascular delivery of drugs or therapeutic agents wherein the effective length of the catheter section which delivers the treatment fluid can be adjusted after the catheter is inserted into the patient's vascular system.
- the catheter assembly in accordance with the invention has an elongated catheter body with an inner lumen which extends from the proximal end thereof to an infusion section in the distal portion thereof having passageways in the wall thereof for discharging fluid from the lumen.
- Longitudinally movable means such as a sheath is provided to adjust the effective length of the infusion section.
- a snugly fitting sheath is slidably mounted onto the exterior of the catheter body so that longitudinal or axial movement of the sheath with respect to the catheter body blocks or unblocks a greater or lesser number of fluid flow passageways in the wall of the infusion section.
- a tubular sheath snugly fits within the interior of the catheter body and is adapted to be slidable therein so that a greater or lesser number of fluid flow passageways passing through the wall of the infusion section are blocked or unblocked to thereby control the effective length of the infusion section.
- the elongated catheter body generally has an outer tubular element and an inner tubular element coaxially disposed within the outer tubular element with the distal ends of these tubular members sealingly bonded together to prevent loss of therapeutic fluids therefrom.
- An annular lumen which is defined between the inner and outer tubular element directs therapeutic fluids from an adapter provided on the proximal end of the catheter body to the distal portion thereof having the infusion section.
- the length of the infusion section in the distal portion of the catheter which is effective in infusing therapeutic fluid may be adjusted prior to or after inserting the catheter into a patient's vascular system. These adjustments are performed from the proximal end of the catheter which normally extends out of the patient during the vascular procedure.
- FIG. 1 is an elevational view partially in section of a drug delivery catheter embodying features of the invention
- FIG. 2 is an enlaged view of the distal end of the catheter shown in FIG. 1 partially in section;
- FIG. 3 is a transverse cross-sectional view of the catheter shown in FIG. 1 taken along the lines 2-2;
- FIG. 4 is an elevational view of another drug delivery catheter embodying features of the invention.
- FIG. 5 is an enlarged sectional view of the distal end of the catheter shown in FIG. 4 taken along the lines 5--5 shown in FIG. 4
- FIG. 6 is a cross-sectional view of the drug delivery catheter shown in FIG. 4 taken along the lines 6--6;
- FIG. 7 is a partial longitudinal view in section of a distal section of a drug delivery system similar to that shown in FIG. 1 with a porous section to discharge fluid through the wall of the catheter.
- the catheter assembly 10 generally includes an elongated catheter body 11 having an outer tubular element 12 and an inner tubular element 13 concentrically disposed therein, an adapter 14 on the proximal end of the catheter body, and an elongated sheath 15 mounted for slidable movement on the exterior of the catheter body 11.
- the distal ends of the inner and outer tubular elements 13 and 12 are sealingly bonded such as by adhesive, heat shrinking, or other suitable means to prevent loss of the treatment fluid therefrom.
- the inner tubular element 13 is provided with an inner lumen 20 adapted to receive a guidewire (not shown) which facilitates advancing the catheter to the desired vascular site.
- the adapter 14 has a side arm 21 which directs therapeutic fluid to the annular lumen 16 in the catheter body 11.
- a guidewire would extend through the proximal end 22 of the adapter into the inner lumen 20.
- the outer elongated tubular sheath 15 is mounted about the outer tubular element 12 for slidable longitudinal movement thereon.
- the distal end of the sheath 15 fits the outer tubular element 12 snugly so as to effectively prevent discharge fluid through the blocked passageways.
- a tightenable collar 23 is provided on the sheath 15 to fix the relative longitudinal position of the sheath with respect to the outer tubular element. It also seals the proximal end of the sheath to prevent leakage of treatment fluid therefrom.
- Radiopaque marker 24 is provided on the distal end of the sheath 15 and radiopaque markers 25 and 26 are provided on the proximal and distal ends of the infusion section 17 to be able to fluoroscopically visualize these components when the catheter is inserted into the patient's vasculature.
- the passageways or ports 18 are provided through the wall of the distal portion of the outer tubular element 12 between the two markers 25 and 26 to infuse therapeutic fluids at a desired vascular site.
- the length of the infusion section 17 which is effective in discharging fluid is varied by changing the relative longitudinal position of the distal end of the sheath 15 thereon to accommodate thrombi of various lengths.
- the catheter assembly 10 is introduced into the patient's vascular system percutaneously through a guiding catheter with a guidewire slidably disposed within the inner lumen 20 of the inner tubular element 12.
- the length thereof which is exposed is adjusted by axial movement of the sheath 15 at the proximal end thereof which extends out of the patient.
- the effective length of the infusion section 17 is preferably the approximate length of the thrombus site to be treated. Other treatment sites of different lengths can also be subsequently treated by readjusting the effective length of the infusion section in essentially the same manner.
- FIGS. 4-6 illustrate an alternative catheter assembly 40 which is similar in many respects to the catheter assembly shown in FIGS. 1, 2 and 3.
- the catheter body 41 has inner and outer tubular elements 42 and 43
- Tubular sheath 45 is slidably mounted within the interior of the tubular element 42 and an adapter 44 provided on the proximal end thereof.
- the proximal end of the outer tubular element 42 is provided with a tightenable collar 46 which sealingly engages the exterior of the sheath 45 and thereby fixes the relative position between the sheath 45 and the outer tubular element 42.
- the proximal ends of the sheath 45 and the inner tubular member 43 are secured to the adapter 44.
- the side arm 47 of adapter 44 directs treatment fluid through the annular passageway 50 disposed between the inner tubular member 43 and the sheath 45 and/or the outer tubular member 42 to the infusion section 51.
- the infusion section 51 is provided with fluid flow passageways 52 for infusing treatment fluid through wall 53 in the outer tubular element 42 to the exterior of the catheter body 41.
- a guidewire (not shown) extends through the proximal end 54 of the adapter 44 into the inner lumen 55 provided in inner tubular element 43.
- FIGS. 3, 4 and 5 operates in a similar manner as the catheter assembly shown in FIGS. 1 and 2 except that the proximal end of the outer tubular element 42 is secured to the exterior of the sheath 45 by means of the collar 46 to fix the relative position therebetween. As the outer tubular element 42 is moved longitudinally over the sheath 45, a greater or lesser number of infusion ports 52 are opened thereby adjusting the effective length of the infusion section 51.
- the fluid flow passageways 18 and 52 of the prior embodiments may be replaced by porous sections 60 formed of suitable plastic material which allows the passage of the treatment fluid from the annular lumen 51 to the exterior of the catheter.
- the entire infusion section can be formed from a porous plastic material.
- the sheath and the inner and outer tubular elements of the catheter body may be formed from suitable plastic materials, such as polyethylene, polyimide and polyesters such as Hytrel 7246, which is a block copolymer of polybutylene terephthalate and long chain polyester glycols.
- Hytrel is a trademark of the DuPont Company.
- Porous plastic materials for fluid discharge may be formed from polypropylene.
- the sheath 15 is typically about 90 cm in length with an inner diameter of about 0.059 inch and an outer diameter of about 0.065 inch.
- the outer tubular element 12 of this embodiment has a length of about 130 cm with an inner diameter of about 0.051 and an outer diameter of about 0.059 and the inner tubular element 13 has a length of about 130 cm, an inner diameter of about 0.040 inch, and an outer diameter of about 0.047 inch.
- typically the sheath 45 is about 90 cm in length with an inner diameter of about 0.051 and an outer diameter of about 0.055.
- the outer tubular element 42 has a length of about 90 cm with an inner diameter of about 0.055 inch and an outer diameter of about 0.063 inch, and the inner tubular element 43 has a length of about 120 cm, an inner diameter of about 0.040 inch, and an outer diameter of about 0.047 inch.
- the dimensions of the components may vary widely, depending upon the vascular use of the catheter.
- the infusion sections 17 and 51 are about 10-30 cm in length, typically about 20, cm with about 30 passageways provided in the wall of the outer members 12 and 42 with effective diameters of about 0.005 inch.
- the passageways are aligned along the length of the outer tubular element in 3 spirals of 10 passageways each. If porous plastic materials are employed for fluid discharge, it should have an effective pore size of about 2 to about 20 microns.
- the number and effective size of the passageways or porous sections will be determined to a large extent upon the desired flow rate of therapeutic fluids and the pressure thereof in the annular lumen between the inner and outer tubular members which form the catheter body.
- the typical values given above were designed for a flow rate of about 80 cc's per hour at a pressure of about 3 to 10 psi. Other flow rates and pressures may require a different number of passageways and different passageway diameters.
- annular lumen in the preferred embodiments described herein, a single annular lumen is employed to direct treatment fluid to the entire infusion section.
- the annular lumen may be compartmentalized as described and claimed in copending application Ser. No. 295,088, filed Jan. 9, 1989 (Dake et al.) which is hereby incorporated by reference in its entirety.
- each compartment of the annular lumen will supply fluid to a particular set of passageways.
- such lumen compartment has a separate source of treatment fluid.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
Claims (12)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/377,243 US4968306A (en) | 1989-07-07 | 1989-07-07 | Intravascular catheter having an adjustable length infusion section to delivery therapeutic fluid |
EP90112965A EP0406901A1 (en) | 1989-07-07 | 1990-07-06 | Intravascular catheter having an adjustable length infusion section to deliver therapeutic fluid |
JP2179423A JPH03131272A (en) | 1989-07-07 | 1990-07-06 | Catheter in blood vessel |
CA002020614A CA2020614A1 (en) | 1989-07-07 | 1990-07-06 | Intravascular catheter having an adjustable length infusion section to deliver therapeutic fluid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/377,243 US4968306A (en) | 1989-07-07 | 1989-07-07 | Intravascular catheter having an adjustable length infusion section to delivery therapeutic fluid |
Publications (1)
Publication Number | Publication Date |
---|---|
US4968306A true US4968306A (en) | 1990-11-06 |
Family
ID=23488330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/377,243 Expired - Lifetime US4968306A (en) | 1989-07-07 | 1989-07-07 | Intravascular catheter having an adjustable length infusion section to delivery therapeutic fluid |
Country Status (4)
Country | Link |
---|---|
US (1) | US4968306A (en) |
EP (1) | EP0406901A1 (en) |
JP (1) | JPH03131272A (en) |
CA (1) | CA2020614A1 (en) |
Cited By (145)
Publication number | Priority date | Publication date | Assignee | Title |
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US5178611A (en) * | 1991-05-01 | 1993-01-12 | Paul Rosenberg | Device and method for inhibiting intravascular device associated infection |
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US5263952A (en) * | 1992-03-25 | 1993-11-23 | Spectranetics | Two-piece tip for fiber optic catheter |
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US5324276A (en) * | 1991-05-01 | 1994-06-28 | Rosenberg Paul H | Device and method for inhibiting intravascular device associated infection |
US5368579A (en) * | 1992-07-23 | 1994-11-29 | Sandridge; James B. | Perfusion controlled guiding catheter apparatus and method |
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Also Published As
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EP0406901A1 (en) | 1991-01-09 |
JPH03131272A (en) | 1991-06-04 |
CA2020614A1 (en) | 1991-01-08 |
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