US10405928B2 - Acetabulum rim digitizer device and method - Google Patents
Acetabulum rim digitizer device and method Download PDFInfo
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- US10405928B2 US10405928B2 US15/013,518 US201615013518A US10405928B2 US 10405928 B2 US10405928 B2 US 10405928B2 US 201615013518 A US201615013518 A US 201615013518A US 10405928 B2 US10405928 B2 US 10405928B2
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- coordinate system
- acetabulum
- orientation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
- A61B2034/2046—Tracking techniques
- A61B2034/2048—Tracking techniques using an accelerometer or inertia sensor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
- A61B2034/2068—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis using pointers, e.g. pointers having reference marks for determining coordinates of body points
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2/4609—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of acetabular cups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4657—Measuring instruments used for implanting artificial joints
- A61F2002/4668—Measuring instruments used for implanting artificial joints for measuring angles
Definitions
- the present application relates to computer-assisted surgery using inertial sensors and more particularly to tools for determining a pelvic tilt for subsequent acetabular cup positioning procedures in hip surgery.
- the acetabulum is reamed to subsequently receive therein an acetabular cup.
- the acetabular cup is an implant that is received in the reamed acetabulum and serves as a receptacle for a femoral head or femoral head implant.
- tools such as a reamer and a cup impactor are used in the procedure.
- One of the challenges in such procedures is to provide an adequate orientation to the acetabular cup. Indeed, an inaccurate orientation may result in a loss of movements, improper gait, and/or premature wear of implant components.
- the acetabular cup is typically positioned in the reamed acetabulum by way of an impactor.
- the impactor has a stem at an end of which is the acetabular cup.
- the stem is handled by an operator that impacts the free end so as to drive the acetabular cup into the acetabulum. It is however important that the operator hold the stem of the impactor in a precise three-dimensional orientation relative to the pelvis so as to ensure the adequate orientation of the acetabular cup, in terms of inclination and anteversion.
- a computer-assisted surgery (CAS) system for tracking an orientation of a pelvis comprising: at least one instrument, the instrument having an acetabulum abutment end adapted to be received in an acetabulum, a rim abutment adapted to be abutted against a rim of the acetabulum, and an indicator representative of a physical orientation of the instrument; at least one inertial sensor unit connected to the at least one instrument, the inertial sensor unit producing readings representative of its orientation; a computer-assisted surgery processor unit operating a surgical assistance procedure and comprising a coordinate system module for setting a pelvic coordinate system from readings of the at least one inertial sensor unit when the at least one instrument has the acetabulum abutment end received in the acetabulum, the coordinate system module setting the pelvic coordinate system by obtaining a plurality of orientation values from the at least one inertial sensor unit when the rim abut
- the at least one instrument has a pin guide thereon adapted to position a pin in the acetabulum in a desired location relative to the pelvic coordinate system.
- the indicator is a light source emitting a light beam on the reference landmark.
- a first of the orientation values obtained has the indicator aligned with a reference landmark.
- said first of the orientation values is programmed from preoperative imaging as being representative of a patient orientation.
- the tracking module tracks at least one tool supporting one of the inertial sensor unit relative to the pelvic coordinate system.
- the tracking module calculates at least one of an anteversion and an inclination of the at least one tool relative to the pelvis.
- a computer-assisted surgery (CAS) system for tracking an orientation of a pelvis comprising: at least one instrument, the instrument having an acetabulum abutment end adapted to be abutted against a rim of the acetabulum in a planned complementary abutment; at least one inertial sensor unit connected to the at least one instrument, the inertial sensor unit producing readings representative of its orientation; a computer-assisted surgery processor unit operating a surgical assistance procedure and comprising a coordinate system module for setting a pelvic coordinate system from readings of the at least one inertial sensor unit when the at least one instrument has the acetabulum abutment end abutted against a rim of the acetabulum in a planned complementary manner, the coordinate system module setting the pelvic coordinate system by defining an acetabular plane representative of the pelvic coordinate system based on the planned complementary abutment; and a tracking module for tracking an orientation of the at least
- the at least one instrument has a pin guide thereon adapted to position a pin in the acetabulum in a desired location relative to the pelvic coordinate system.
- the tracking module tracks at least one tool supporting one of the inertial sensor unit relative to the pelvic coordinate system.
- the tracking module calculates at least one of an anteversion and an inclination of the at least one tool relative to the pelvis.
- the acetabulum abutment end is a tripod having three abutment tabs adapted to be abutted in the planned complementary abutment.
- the acetabulum abutment end is patient-specifically fabricated based on preoperative imaging of the patient.
- the acetabulum abutment end has adjustable prongs connected to a remainder of the instrument by a lockable joints, for the acetabulum abutment end to be arranged for the planned complementary abutment based on preoperative imaging of the patient.
- each said prong has a translational DOF joint and a rotational DOF joint.
- a method for tracking an orientation of a pelvis in computer-assisted hip surgery comprising: obtaining an instrument having an inertial sensor unit, an acetabulum abutment end adapted to contact a rim of an acetabulum, and a rotation indicator; initializing an orientation of the instrument with the acetabulum abutment end against the rim of the acetabulum and with the rotation indicator aligned with a pelvic landmark; recording the orientation for at least the initial orientation; defining an acetabular plane representative of a pelvic coordinate system from the orientation; and producing orientation data relative to the pelvic coordinate system using inertial sensor units.
- producing orientation data comprises producing anteversion and/or inclination angles of a tool with an inertial sensor unit relative to the pelvis.
- recording the orientation comprises recording a plurality of orientation values each associated with a different contact location between the rim and the acetabulum abutment end.
- initializing an orientation of the instrument with the acetabulum abutment end against the rim of the acetabulum and with the rotation indicator aligned with a pelvic landmark is based on preoperative imaging representative of a patient orientation.
- FIG. 1 is a perspective view of an acetabulum rim digitizer device in accordance with the present disclosure, relative to a pelvis;
- FIG. 2 is an enlarged perspective view of a tooling end of the acetabulum rim digitizer device of FIG. 1 ;
- FIG. 3 is an enlarged elevation view of a tooling end of an acetabulum rim digitizer device with planar surface in accordance with another embodiment of the present disclosure
- FIG. 4 is a perspective view of the acetabulum rim digitizer device of FIG. 3 ;
- FIG. 5 is a perspective view of an acetabulum rim digitizer device with prongs in accordance with another embodiment of the present disclosure.
- an acetabulum rim digitizer device or instrument is generally shown at 10 , relative to a pelvis P having an acetabulum A, the acetabulum having a rim R.
- the device 10 and method related to the device 10 may be used to determine pelvic orientation data in various forms (e.g., pelvic tilt, anteversion/inclination of acetabulum, etc).
- the device 10 may also be used to accurately navigate instruments used in hip arthroplasty or like procedures, including bone model and cadaver testing, such as an acetabular reamer, a cup impactor, an impactor guiding pin, using inertial sensors.
- the device 10 has an elongated body 11 having a tooling end 12 and a handle end 14 . Although illustrated as having an axially offset portion, the body of the device 10 may also be fully straight or have any other appropriate shape.
- the device 10 has a receptacle 16 for releasably receiving therein an inertial sensor unit 18 , in a known manner.
- the inertial sensor unit 18 may be integral or embedded into the elongated body 11 .
- the inertial sensor unit 18 may have a gyroscope set to track the orientation of the device 10 , by integrating the angular velocity data recorded by the sensor through a registration process.
- the inertial sensor unit 18 may also comprise an accelerometer set used to calibrate an initial position of the device 10 , and to correct gyroscope drift when stable positions are recorded.
- Other types of inertial sensors may be provided in the inertial sensor unit 18 to complement the data or as alternatives to the accelerometer and/or gyroscope, such as inclinometers, magnetometers, among other possible inertial sensors.
- the inertial sensor unit 18 uses its inertial sensor readings to continually calculate the orientation and velocity of a body without the need for an external reference, i.e., no signal transmission from outside of the sensor assembly is necessary, the inertial sensor unit 18 is self-contained. This process is commonly known as dead reckoning and is documented and forms part of the common general knowledge. An initial orientation and velocity must be provided to the inertial sensor unit 18 , i.e., the X-Y-Z coordinate system of FIG. 1 , after which the orientation is tracked by integrating the angular rates of gyroscope readings at each time step.
- Wth an accurate estimate of the orientation of the inertial sensor unit 18 with respect to the World frame of reference, gravitational effects can be removed and inertial forces acting on the accelerometers can be integrated to track changes in velocity and position. Since the inertial sensor unit 18 has no need for an external reference, it may be immune to environmental factors such as magnetic fields and operate under a wide range of conditions.
- the inertial sensor unit 18 is part of a computer-assisted hip surgery system for navigating instruments, used to implement the method 10 , as will be detailed below.
- the system comprises a computer-assisted surgery (CAS) processing unit 19 , that may be a stand-alone computer connected to the inertial sensor unit 18 , for instance by wireless communication. It is however pointed out that the CAS processing unit may be partially or entirely integrated into the inertial sensor unit 18 , also known as pod.
- the inertial sensor unit 18 when incorporating the CAS processing unit, may thus be equipped with user interfaces to provide the navigation data, whether it be in the form of LED displays, screens, numerical displays, etc.
- the computer-assisted surgery (CAS) processing unit 19 may have a coordinate system module 19 A and a tracking module 19 B, described in further detail hereinafter, and part of a surgical assistance procedure programmed into the CAS processing unit 19 .
- a hemispherical base 20 is secured to the tooling end 12 .
- the base 20 may be releasably connected to the body 11 (e.g., by screwing engagement) to enable the selection of a base 20 of appropriate dimension, based on the acetabulum being operated on.
- the geometry of the base 20 may be known as quasi-hemispherical, frusto-spherical, etc. Indeed, as the base 20 is seated into the acetabulum during registration, it is expected that the base 20 is well seated in the acetabulum and does not shift position during the registration process.
- pressure sensor(s) may be provided on or near the surface of the base 20 . The pressure sensor(s) provides signals that can be monitored to determine whether the base 20 is adequately applied against the surface of the acetabulum.
- the device 10 may additional comprise a tab 22 , which is spaced apart from the base 20 and is designed to be seated on the acetabulum rim for each acquired points, as observed in FIGS. 1 and 2 .
- the device 10 may further have a rotation indicator 24 , used to define a fixed rotation axis, not parallel to the rim plane normal, to build a full coordinate system for the acetabulum.
- the rotation indicator 24 is a light source emitting a visible light beam, although other rotation indicators may be used such as a mechanical arm, a laser, a marking on the instrument, or any other visual indicator.
- a pin guide 26 may also be provided as projecting laterally from the elongated body 11 , featuring a slot for guiding the insertion of a pin 28 in the pelvis, following the registration.
- the rotation indicator 24 is in a known physical orientation in the coordinate system of the inertial sensor unit 18 .
- the CAS processing unit is programmed with geometric data relating the body 11 (e.g., its axes) to the orientation of the components thereon, such as the base 20 , the tab 22 and the rotation indicator 24 .
- This geometric data obtained pre-operatively, is used by the CAS processing unit (shown as 18 ) to perform the method and sequence described below.
- the acetabulum rim digitizer device 10 may be used intra-operatively with the following intraoperative method:
- the base 20 of the device 10 is seated into the acetabulum A.
- the base 20 has been selected and installed to have a diameter complementary to that of the acetabulum A.
- the rotation indicator 24 is used to give a predetermined orientation to the device 10 .
- this rotation indicator 24 may be oriented to point, mark, touch a pre-operatively identifiable landmark.
- the identifiable landmark may be lateral anterior-superior iliac spine (ASIS), the 12 o'clock feature of the acetabulum rim, the acetabulum notch, among other features.
- Registration may be initiated, through the user interface of the CAS processing unit (e.g., button on the inertial sensor unit 18 is turned on).
- the device 10 is manually rotated to position the tab 22 onto a different segment of the acetabulum rim R ( FIG. 2 ).
- the inertial sensor unit 18 records the current orientation of the digitizer device 10 and provides feedback to the user, for confirmation.
- steps 4-5 are repeated until a sufficient number of acetabulum rim positions are recorded by the inertial sensor unit 18 , for instance as indicated by the inertial sensor unit 18 or based on a predetermined number of measurements required.
- the CAS processing unit (e.g., incorporating the inertial sensor unit 18 ) then records and provides data related to the acetabulum orientation or pelvic tilt, in any appropriate form (i.e., the pelvic coordinate system).
- the CAS processing unit must be programmed in the following sequence:
- the CAS processing unit sets the initial orientation of the acetabulum rim digitizer device 10 when the user initiates the initial recording. This initial position is recorded by assuming arbitrary yaw, roll and pitch are provided by the accelerometer set in the inertial sensor unit 18 . From this initial position, and knowing the orientation of the rotation indicator 24 relative to the rim digitizer device 10 , the rotation axis may be defined as: rotation!xtsInWorld
- the gyroscope set in the inertial sensor unit 18 is used to track the orientation of the acetabulum rim digitizer device 10 .
- the orientation of the device 10 is recorded at the various points of contact between the tab 22 and the acetabulum rim R.
- the inclination data (roll & pitch) provided by the accelerometer set in the inertial sensor unit 18 may be used to correct drift in the gyroscope data (for instance, using Kalman or Complementary filters).
- the collection of orientation data at various points provides the orientation of the rim digitizer device 10 in the World coordinate system: rimDigitizerInWorld
- the position of the tab 22 may thus be calculated based on the orientation of the rim digitizer device 10 obtained.
- Each of these positions is recorded in a coordinate system maintained by the CAS processing unit, and is representative of a point on the acetabulum rim R.
- the origin of the coordinate system is located at the center of the hemispherical base 20 .
- the rim points registered can be used to define an acetabular rim plane.
- a plane is fitted through the rim points using an appropriate method such as Least Squares Fitting. This acetabular rim plane is therefore known: rimPlaneNormalInWorld
- the pelvis coordinate system is created. Any standard definition may be used, for example the Lewinnek pelvic coordinate system.
- the pre-operative planning data may be referenced to the acetabulum coordinate system, using the same landmarks and rotation features as used during the registration method.
- the gravity axis of the World coordinate system may also be used to determine the pelvic tilt from the computed pelvisInWorld coordinate system.
- the acetabular rim plane acquired with landmarks may be matched with a plane defined in pre-operative planning.
- the CAS processing unit may instead match the rim landmarks with a surface defined in pre-operative planning. This surface can be a 3D surface representing the acetabulum rim contour.
- the CAS processing unit can calculate using Least Squares Fitting the transformation on the acquired rim points which positions the points closest to the pre-planning contour of the acetabulum rim R.
- the surface can also be a set of 2D contours, acquired using X-Rays images, combined with respective projective camera calibrations.
- camera calibration could be performed as per F. CHERIET et al, Int. J. Patt. Recogn. Artif. Intell. 13, 761 (1999).
- the CAS processing unit could compute by Least Squares Fitting the transformation on the acquired rim points for which a retro-projection of the points onto the X-Ray, as defined by the projective camera model, is closest to the defined 2D contour.
- an ultrasound device may be fixed to the device 10 , for ultrasound readings to be obtained when the device 10 is seated into the acetabulum A.
- the ultrasound readings may be used to create the rim surface, and thus replaces the tab 22 of the device 10 , alleviating the need for physical contact with the acetabulum rim R.
- the pin 28 may be positioned to a desired orientation, using the orientation data.
- the pin 28 may be driven into the pelvis so as to serve as an impactor guide.
- the longitudinal axis of the pin 28 could thus be driven to an orientation parallel to a normal of the acetabulum rim plane.
- the navigation of the device 10 for pin placement is done by providing anteversion and inclination values to the user.
- a planar surface 30 may be used as an alternative to the tab 22 at the tooling end 12 of the elongated body 11 .
- the base 20 may or may not be present, although the base 20 may provide some manipulation stability to aid in applying the planar surface 30 to the acetabular rim R.
- the device 10 of FIGS. 3 and 4 could be used to acquire, in a single step, the planar surface as well as the rotation landmark.
- the device 10 has a configuration that is planned to be in a unique complementary engagement with the rim of the acetabulum, for instance based on pre-operative imaging for instance by having patient specific contact surfaces being negatives of patient tissue for unique complementary engagement.
- steps 4-6 of the method described above would not be necessary, provided suitable pre-planning is performed.
- steps 2-4 of the sequence performed by the CAS processing unit are no longer required.
- the inertial sensor unit 18 may not need a gyroscope set for the embodiment of FIGS. 3 and 4 .
- three adjustable prongs 50 may be used as alternatives to the planar surface 30 , effectively forming a tripod.
- the user is requested to position all of the prongs onto known landmarks (e.g., unique complementary engagement, based on pre-operative imaging).
- the prongs 50 have abutment ends 51 , displaceable axially (e.g., along a longitudinal axis of the body 11 ) and in rotation (e.g., about an axis parallel to the longitudinal axis of the body 11 ).
- the prongs 50 are each provided with a housing 52 enabling lockable translational DOF and rotational DOF.
- the known landmarks against which the ends 51 of the prongs 50 are to be abutted are either defined by identifiable anatomical landmarks, or by for instance, constraining the rotation of the instrument by using a stopper in the acetabulum notch.
- the pre-operative planning is be used to define the unique adjustments to the tripod to extend to the prongs 50 , and to identify the unique position of the device 10 when positioned into the acetabulum A with the predetermined abutment between the prongs 50 and the pelvis P.
- a method used in combination with the device 10 of FIG. 5 would be as follows:
- a coordinate system is created from these three landmarks, the relationship between this coordinate system and pelvis coordinate system would also be known from pre-operative planning.
- the device 10 is then positioned in the manner shown in FIG. 5 onto the pre-identified landmarks, either visually or by using a mechanical feature to constrain rotation.
- pelvisInWorld tripodInWorld ⁇ pelvisInTripod
- the device 10 of any of the preceding figures is therefore used to provide a means for intra-operatively evaluating the tilt of the pelvis and obtain acetabular orientation data, whether the surgery is performed in supine or lateral decubitus.
- the data provided by the CAS processing unit may be used, for instance, to reposition the pelvis onto the table, to guide the user in aligning a non-navigated instrument with a desired cup alignment or be used as an input for navigation of surgical instruments during total hip arthroplasty procedure.
- cross-products of axes are discussed above, vectors representative of a direction of the axes may be used for the cross-products.
- the CAS processor unit 19 may have a coordinate system module 19 A and a tracking module 19 B. Based on the embodiment the CAS processor unit 19 supports, the modules 19 A and 19 B may have different functions.
- the coordinate system module 19 A sets a pelvic coordinate system from readings of the inertial sensor unit 18 when the at least one instrument 10 has the acetabulum abutment end received in the acetabulum.
- the coordinate system module 19 A sets the pelvic coordinate system by obtaining a plurality of orientation values from the inertial sensor unit 18 when the rim abutment tab 22 is abutted against locations of the rim.
- One of the orientation values has the indicator 24 aligned with a reference landmark.
- the coordinate system module 19 A defines an acetabular plane representative of the pelvic coordinate system from the plurality of orientation values.
- the tracking module 19 B then tracks an orientation of inertial sensor units relative to the pelvic coordinate system during movements thereof using the readings from the inertial sensor units.
- the coordinate system module 19 A sets a pelvic coordinate system from readings of the inertial sensor unit 18 when the instrument 10 has the acetabulum abutment end abutted against a rim of the acetabulum in the planned complementary manner.
- the coordinate system module 19 A sets the pelvic coordinate system by defining an acetabular plane representative of the pelvic coordinate system based on the planned complementary abutment.
- the tracking module 19 B then tracks an orientation of inertial sensor units relative to the pelvic coordinate system during movements thereof using the readings from the inertial sensor units.
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Abstract
Description
rotation!xtsInWorld
rimDigitizerInWorld
rimPointInWorld=rimDigitizerInWorld·tabInRimDigitizerCenter
rimPlaneNormalInWorld
rimXAxis=rimPioneNormalInWorld
rimZAxis=rimTZxis·rotationAxisInWorld
rimTAxis=rimZAxis·rimXAxis
acetabulumInWorld=[rimXAxis rimYAxis rimZAxis]
pelvisInWorld=acetabulumInWorld*pelvisInAcetabulum
pelvisInWorld=tripodInWorld·pelvisInTripod
Claims (13)
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US15/013,518 US10405928B2 (en) | 2015-02-02 | 2016-02-02 | Acetabulum rim digitizer device and method |
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US201562110872P | 2015-02-02 | 2015-02-02 | |
US15/013,518 US10405928B2 (en) | 2015-02-02 | 2016-02-02 | Acetabulum rim digitizer device and method |
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US20160220315A1 US20160220315A1 (en) | 2016-08-04 |
US10405928B2 true US10405928B2 (en) | 2019-09-10 |
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EP (1) | EP3253322B1 (en) |
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US20180280037A1 (en) * | 2017-03-31 | 2018-10-04 | Tornier | Positioning system for a bone resecting instrumentation and positioning kit |
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US20160220315A1 (en) | 2016-08-04 |
CA2974837A1 (en) | 2016-08-11 |
EP3253322B1 (en) | 2020-03-11 |
EP3253322A1 (en) | 2017-12-13 |
EP3253322A4 (en) | 2019-01-16 |
CN107205783B (en) | 2020-04-14 |
CN107205783A (en) | 2017-09-26 |
WO2016123703A1 (en) | 2016-08-11 |
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