TWI646893B - Fungicidal composition and use thereof - Google Patents

Abstract

A fungicidal composition is provided. The composition comprises at least three active ingredient components (A), (B), and (C), and one or more conventional formulation aids as needed, wherein component (A) is a One or more strobilurin fungicides, component (B) is one or more benzimidazole fungicides, and component (C) is fluazinam. A method for treating plants using the composition is further provided. In addition, it provides a method for preventing and / or combating plant or plant material pathogenic damage or pest damage, which method comprises administering an active ingredient (A), (B) and ( C) a composition wherein component (A) is one or more strobilurin fungicides, component (B) is one or more benzimidazole fungicides, and component (C) It is fluazinam.

Description

Fungicidal composition and use thereof

The invention relates to a fungicidal composition and its use for controlling fungal infections in plants. The invention further provides methods for treating plants and plant matter to combat or prevent fungal infections.

Specific compositions for controlling fungi and fungal hazards are known to the art and described in the literature. The properties of these known compositions need to be improved, particularly in terms of fungal control, phytotoxicity, harmful effects of the environment, and adverse effects of worker exposure. In addition, when the target fungus develops resistance to a combination of known active ingredients, there is a need for improved methods for preventing and preventing fungal infections.

Therefore, there is a continuing need for compositions that provide environmentally acceptable fungicidal active ingredients, which provide, for example, improved biological and / or synergistic properties, particularly in terms of controlling fungal infections of plants and plant matter.

As mentioned above, formulations of compositions including fungicidal active ingredients are known in the art. For example, US 5,468,747 provides fungicidal compositions including azoxystrobin and carbendazim.

CN 102150656 discloses the use of subtropical and pyridine bactericides for the prevention and control of plant diseases.

CN102119697 relates to the use of a fungicidal mixture of subtomin and fugemine for the treatment of agricultural plant diseases.

It has been found to be advantageous to provide a fungicidal composition comprising (A) strobilurin, (B) benzimidazole and (C) fugemine as active ingredients. In particular, it has been found that this composition exhibits a synergistic effect in combating and preventing fungal infections. The synergistic nature of the aforementioned fungicidal active ingredient composition allows the applied dose to be reduced, thereby being more environmentally friendly, and, more importantly, having the effect of preventing the target fungus from developing resistance to the active ingredient.

The present invention relates to a fungicidal composition comprising the components (A) strobilurin, (B) benzimidazole and (C) fugemine and use thereof for controlling fungal infections in plants. The present invention further relates to a method for combating or preventing a fungal infection using the aforementioned composition of a fungicidal active ingredient.

Therefore, in a first aspect, the present invention provides a fungicidal composition comprising the following fungicidal active components: (A) strobilurin; (B) benzimidazole; and (C) fugemine.

The strobilurin and strobilurin-type fungicides are a well-known fungicide which is extracted from the fungus Strobilurus tenacellus and has a wide range of disease control. Strobilurin has inhibitory effects on other fungi and reduces competition for nutrients. Strobilin inhibits the electron transfer between cytochrome b and cytochrome C ₁ at the ubiquinol oxidation site of the mitochondria, disrupts metabolism and prevents the growth of target fungi. Examples of strobilurins include azoxystrobin, dimoxystrobin, famoxadone, fenamidone, fluoxastrobin, kresoxim- methyl), metaminostrobin, picoxystrobin, pyraclostrobin, and triflxystrobin.

Benzimidazole is a systemic fungicide with dual protective and therapeutic effects. The benzimidazole system is taken up by the leaves and roots of the plant, with a translocation effect substantially toward the apex, and works by inhibiting β-tubulin polymerization. Examples of benzimidazole are albendazole, benomyl, carbendazim, hlorfenazole, cypendazole, debacarb, wheat Suining (fuberidazole), mecarbinzid, rabenzazole, thiabendazole, and thiofanate-methyl.

The fuguline system is disclosed in EP 0 031 257. Fugamide has broad-spectrum antifungal properties and exhibits good preventive effects against plant diseases. It is effective against industrial products, seeds and stored fruits against pests, mites, fungi and bacteria, as well as for controlling crops and horticultural crops and the growth of harmful organisms on high ground.

In a second aspect, the invention provides the use of a composition as defined hereinbefore to prevent and / or combat fungal infections of plants, especially crops.

In a third aspect, the present invention provides a method for protecting a plant against fungal infection by applying a composition as defined above to a plant, one or more parts thereof (such as leaves or seeds) or its location.

In a fourth aspect, the invention also provides a plant-protection product comprising a composition as defined above.

The invention also relates to a plant or plant material treated with a composition as defined hereinbefore, which plant or plant material is treated or treated to combat an existing fungal infection before a fungal infection.

Surprisingly, it has been found that a combination of at least one strobilurin active ingredient (A), at least one benzimidazole active ingredient (B), and fugemine active ingredient (C) Fungal infections have unexpectedly enhanced effects, especially for agricultural effects such as soybeans, cotton, dried beans, sugar cane, tomatoes, potatoes, and rice.

In particular, the composition is useful for treating and / or preventing fungal infections, especially Sclerotinia sclerotiorum , Rhizoctonia solani , Streptomyces scabies , Phytophthora infestans ), Fusarium oxysporum (Fusarium oxysporum) bacteria, the genus Pythium (Pythium spp.) and fungi Ceratocystis singular (Ceratocystis paradoxa) having a striking highly active. The increase in the effect and / or other advantageous properties achieved with the compositions of the present invention is significantly greater than the expected activity of the individual components or the combination of strobilurin, benzimidazole, and fugemine. The activity of the active ingredients is synergistically enhanced, including extending the boundaries of the fungicidal activity of these compounds.

As mentioned above, the present invention provides a method for treating or preventing a fungal infection using a composition of (A) strobilurin, (B) benzimidazole, and (C) fugemine. This method includes treating plants with (1) at least one strobilurin active ingredient (A), (2) at least one benzimidazole active ingredient (B), and (3) fugemine active ingredient (C). Or one or more parts thereof, such as leaves or seeds. The active ingredient components (A), (B) and (C) can be administered continuously or simultaneously in any desired order, in any combination. Preferably, the method is performed by applying a composition as defined above, that is, a composition including at least one component (A) and (B) and component (C) to the plant.

The fungicidal active ingredient strobilin, component (A), can be present in the composition of the present invention in any suitable amount. Preferably, the strobilurin is present in an amount of 1% to 50% by weight of the composition, and more preferably 5% to 20% by weight of the composition.

The strobilurin, component (A) may be any fungicidal active strobilurin compound or a combination of these compounds. These compounds are known in the art and suitable strobilurins are commercially available. The strobilurin compound is preferably one or more selected from the group consisting of subtoxamine, oxystrobin, vanacone, imidaclostrobin, fluoxastrobin, closoxan, phenoxystrobin, picoxystrobin , 100 grams of min and triflumin.

The fungicidal active ingredient benzimidazole, component (B), may be present in the composition in any suitable amount. The benzimidazole is preferably 1% to 70% by weight of the composition, more preferably 5% to 60% by weight of the composition, and still more preferably 20% to 50% by weight of the composition. The amount exists.

The benzimidazole, component (B) may be any fungicidal active benzimidazole or a combination of these compounds. These benzimidazole compounds are known in the art, and suitable benzimidazoles are commercially available. The benzimidazole compound is preferably one or more compounds selected from the group consisting of non-radide, befentin, maitinin, rot, and methyl polysulfide.

The fungicidal active ingredient fugemine, component (C), may be present in the composition in any suitable amount. Preferably, fugulimide is 1% to 90% by weight of the composition, more preferably 10% to 80% by weight of the composition, and still more preferably 15% to 75% by weight of the composition. The amount is present in the composition.

Components (A), (B), and (C) may be present in the composition in any amount in proportion to each other to provide an enhanced or synergistic effect of the mixture. In particular, preferably, the weight ratio of any two components (A), (B) and (C) in the composition is independently from 25: 1 to 1:25, 20: 1 to 1:20 , Or 15: 1 to 1:15, more preferably 10: 1 to 1:10, 5: 1 to 1: 5, or 2.5: 1 to 1: 2.5. The ratio of the component (A) and the component (B) of the composition may range from 1: 1 to 1:10, more preferably 1: 2 to 1: 8. The ratio of the component (A) and the component (C) of the composition may range from 1: 1 to 1: 6, and more preferably 1: 1 to 1: 5. Similarly, the ratio of the component (B) and the component (C) of the composition may range from 1: 1 to 4: 1, and more preferably 1: 1 to 3: 1. In some specific embodiments, the components (A), (B), and (C) are 1: 5: 3, 1: 5: 5, 1: 2: 1, 2: 7: 4, 2: The weight ratio of 4: 3, 2: 8: 5, 1: 3: 2, or 1: 7: 3 is present in the composition.

The composition of the present invention may include one or more auxiliaries. The adjuvant used in the composition will depend on the formulation and / or the manner in which the end user applies the formulation. The formulations incorporated into the composition of the invention are described below. Suitable adjuvants that can be included in the composition of the present invention are conventional formulation adjuvants or components, such as organic solvents, stabilizers, defoamers, emulsifiers, antifreeze agents, preservatives, antioxidants, pigments, Thickeners and inert fillers. It is known in the art to use such auxiliary components for formulating compositions and the auxiliary agents themselves are known in the art and are commercially available.

The fungicidal composition of the present invention optionally includes one or more surfactants. This surfactant is preferably naturally nonionic, cationic and / or anionic. Mixtures of surfactants with good emulsifying, dispersing and wetting properties are preferred. The choice of surfactants depends on the active ingredients to be formulated and the type of formulation used. Suitable surfactants are known in the art and are commercially available.

Examples of suitable surfactants are polyoxyethylene (POE) sorbitan esters, such as POE (20), sorbitan trioleate, and polyoxyethylene (POE) sorbitan esters, such as POE (40). Sorbitol oleate. POE (20) sorbitan trioleate is commercially available under the trade names ATLAS G1086 and CIRRASOL G1086 and are sold by UniqEMA. POE sorbitan esters and POE sorbitan esters optimize the HLB (hydrophilic-lipophilic balance) of the surfactant. Therefore, when water is added to the composition, the highest quality emulsion (minimum suspension droplets) is obtained. Higher quality emulsions typically produce the best fungicidal performance.

Suitable cationic surfactants include a quaternary ammonium salt, which is an N-substituted, at least one C ₈ -C ₂₂ group, and is another substituent, unsubstituted or halogenated lower benzyl or lower hydroxyl -An alkyl group. The salts are preferably in the form of a halide, methyl sulfate or ethyl sulfate. Examples of such cationic surfactants are stearyltrimethylammonium chloride and benzylbis (2-chloroethyl) ethylammonium bromide.

Suitable anionic surfactants can be so-called water-soluble soaps and water-soluble synthetic surface-active compounds. Useful soaps include alkali metals, alkaline earth metals or ammonium salts of substituted or unsubstituted higher fatty acids (ie, C ₁₀ to C ₂₂ fatty acids). Examples of such surfactants are, for example, oleic acid or stearic acid, or sodium or potassium salts of natural fatty acid mixtures.

Examples of other surfactants that can be used are salts of polyacrylic acid, salts of ligninsulfonic acid, salts of benzenesulfonic acid or naphthalenesulfonic acid, ethylene oxide with fatty alcohols or with fatty acids or with fatty amines Polycondensates, substituted phenols, especially alkylphenols, sulfosuccinate salts, taurine derivatives, especially alkyl taurates or polyethoxylated phenols or phosphates of alcohols.

When the active ingredient and / or inert carrier and / or adjuvant / adjuvant are insoluble in water and the vehicle for the final application of the composition is water, it is generally necessary to have at least one surfactant.

The amount of surfactant present in the composition will depend on these and therefore depends on the type of formulation used.

The fungicidal composition of the present invention further comprises one or more polymer stabilizers. Suitable polymer stabilizers useful in the present invention include, but are not limited to, polymers such as polypropylene, polyisobutylene, polyisoprene, copolymers of mono- and diolefins, polyacrylates, polystyrene, Polyvinyl acetate, polyurethane or polyamide. Suitable stabilizers are known in the art and are commercially available.

The surfactants and polymer stabilizers mentioned above generally impart stability to the composition, thereby allowing the composition to be formulated, stored, transported, and applied.

The composition of the invention may include one or more defoamers. Suitable defoamers include all substances which are generally useful for the purpose of agrochemical compositions. Suitable defoamers are known in the art and are commercially available. A particularly good defoamer is a mixture of polydimethylsiloxane and perfluoroalkylsulfonic acid, such as a silicone defoamer from GE or Compton.

Depending on the type of formulation, the composition of the invention may include one or more organic solvents. Suitable organic solvents may be selected from conventional organic solvents that completely dissolve the agrochemical active substance. Furthermore, organic solvents suitable for the active ingredient components (A), (B) and (C) are known in the art. Mention may be made of the following solvents: N-methylpyrrolidone, N-octylpyrrolidone, cyclohexyl-1-pyrrole Ketones; or Solvesso 200, a mixture of paraffin, isoparaffin, cycloparaffin, and aromatic hydrocarbons. Suitable solvents are commercially available.

The composition may include one or more preservatives. Suitable preservatives include all substances commonly used for this type of agrochemical composition for this purpose and are well known in the art. Suitable preservatives that may be mentioned include tolylfluanid, such as Preventol® (commercially available from Bayer AG), and benzoisothiazolinones, such as Proxel® (commercially available from Bayer AG) ).

This composition may further include one or more antioxidants. Suitable antioxidants include those substances which are generally used for agrochemical compositions for this purpose, as known in the art. A particularly preferred antioxidant is butylhydroxytoluene.

This composition may also include one or more thickeners. Suitable thickeners include those materials which are generally used for agrochemical compositions for this purpose. Suitable thickeners include, for example, xanthan gum, PVOH, cellulose and its derivatives, clay hydrated silicates, magnesium aluminum silicate, or mixtures thereof. Also, these thickeners are known in the art and are commercially available.

In addition, depending on the formulation, the composition of the present invention may also include water.

As discussed above, the composition of the present invention includes a strobilurin component (A), a benzimidazole component (B), and a fugulimide component (C). In a preferred embodiment, the composition of the present invention comprises the following combination of the aforementioned active ingredients: (A) azoxystrobin, (B) carbendazim, (C) fugemine (A) dimoxystrobin, (B) benomyl, (C) fugemine; (A) famoxadone, (B) fuberidazole, (C ) Fostigamide; (A) fenamidone, (B) thiabendazole, (C) fugemine; (A) fluoxastrobin, (B) methyl poly net (thiofanate-methyl), (C) fugemine; (A) kresoxim-methyl, (B) carbendazim, (C) fugemine; (A) fenoxystromine ( metaminostrobirn), (B) carbendazim, (C) fugemine; (A) picoxystrobin, (B) thiabendazole, (C) fugemine; (A) Pyraclostrobin, (B) carbendazim, (C) fugemine; or (A) triflxystrobin, (B) carbendazim, (C) fugemine .

The composition of the present invention can be used in agricultural parts and related fields for controlling or preventing plant diseases, infections and / or pest damage.

The composition of the present invention is effective against fungi, including (but not limited to) the following: ‧ Vegetables, rapeseed, sugar beet and fruits, and Alternaria on rice, such as potatoes and tomatoes Phytophthora sp chain spacers (of A. solani) or a cross-chain spacer cinerea (A.alternata), ‧ sugar Aphanomyces spp (Aphanomyces) on the beet and vegetables, eggplant bursa of cereals and vegetables class ‧ Two spores, ‧ Bipolaris and Drechslera of corn, cereals, rice and grassland, ‧ Blumeria graminis (white powdery mildew) on cereals, ‧ strawberries Botrytis cinerea ( Botrytis ) on vegetables, flowers, flowers and vines, Bremia lactucae on lettuce, ‧ Ceratocystis paradoxa on sugar cane, ‧ corn Cercospora on soybeans, soybeans, rice and sugar beets, such as Cercospora kikuchii on soybeans (end-stage disease-leaf spot), ‧ spiral cavities on corn, soybeans, rice genus (Cochlibolus), for example a spin on the cereal grain Chamber bacteria (Cochliobolus sativus), Miyabe's Cochliobolus (Cochliobolus miyabeanus) on the rice, ‧ soybean and blunt anthrax on the cotton (Colletotrichum truncatum) (anthrax), delbrueckii on the ‧ corn, cereals, rice and grass Drechslera , such as D. teres on barley or D. tritici-repentis on wheat, ‧ by Phaeoacremonium chlamydosporium , Ph . Aleophilum and Formitipora punctata Phellinus punctatus ) caused Esca on the vine ‧ Elsinoe ampelina on the vine , ‧ Exserohilum on corn, ‧ Erysiphe diffusa (powdery mildew) on cucumbers, ‧ Fusarium and Verticillium on various plants, such as F.graminearum on cereals or F.culmorum or various plants such as F.oxysporum on tomato, ‧ Gaeumanomyces graminis on cereals, ‧ Red on cereals and rice Gibberella (such as Gibberella fujikuroi on rice), ‧ Glomerella cingulata on vines and other plants, ‧ Grainstaining complex on rice, ‧ tee bacteria (Guignardia budwelli) on the vine, the length of ‧ maize and rice Helminthosporium (Helminthosporium), brown spot fungus Isaria proposed (Isariopsis clavispora) ‧ on the vine, the ‧ snow mold on cereals bacterial leaf blight (Michrodochium nivale), ‧ cereals, Mycosphaerella (Mycosphaerella) on the bananas and peanuts, for example, Leptosphaeria of Fiji (M.fijiensis) on Mycosphaerella graminicola (M.graminicola) on the wheat or banana , ‧ downy mildew on cabbage and bulbous plants of the genus (Peronospora), such as Brassica downy mildew (P.brassicae) on the cabbage, onion downy mildew (P.destructor) on the onion and soy northeast of dual mold fungi (frost ), ‧ Phakopsora pachyrhizi (soy rust) and Phakopsara meibomiae on soybeans, ‧ Phomopsis on grapes and vines Viticola on the (P.Viticola), ‧ potato and Phytophthora infestans (Phytophthora infestans) of tomato on a variety of Phytophthora (Phytophthora) on the plant species, such as the chili pepper Phytophthora (P.capsici ), ‧ Plasmopara viticola on vines, ‧ Podosphaera leucotricha on apples , ‧ Pseudocercosporella herpotrichoides on cereals , ‧ on various plants the proposed downy mildew (Pseudoperonospora) species, such as Cuba on the proposed cucumber downy mildew (P.Cubensis) Humulus or hop on the drafting of downy mildew (P.Humili), grape vine corner spot on the leaf scorch ‧ germs (Pseudopezicula tracheiphillai ), various ‧ per Puccinia (Puccinia) on plants of the genus Puccinia such as wheat (P. triticina) on the cereal, rust Puccinia (P.striformis), stem rust of barley (P. hordei) or handle Wo rust (P.graminis), or asparagus stalk of asparagus rust (P.asparagi), ‧ on the rice blast fungus (Pyricularia oryzae), Sasa wood Corticium bacteria (Corticium sasakii), broom stems column Alternaria (Sarocladium ory zae ), S. attenuatum , Entyloma oryzae , ‧ Pyricularia grisea on grass and cereals, ‧ lawns, rice, corn, cotton, oilseed rape, sunflower, sugar Pythium (Pythium) on the sugar beet, vegetables and other plant genus, for example, Pythium fungi (P.ultiumum) on a variety of plants, the Pythium lawn (P .aphanidermatum), ‧ cotton, rice , Rhizoctonia on potato, grass, corn, rape, sugar beet, vegetables and various plants, such as R. solani on potato and various plants, ‧ barley, black Rhynchosporium secalis on wheat and triticale, Sclerotinia on rapeseed and sunflower, Septoria tritici Stagonospora nodorum), soybean and Sclerotinia sclerotiorum (Sclerotinia sclerotiorum) of bacteria on dry beans, Septoria (Septoria glycines) (soybeans brown spot) on soybeans of ‧, Uncinula necator on grapevines of ‧ (Erysiphe (with Words Uncinula) necator), ‧ maize and hair Leptosphaeria (Setospaeria) on the grass species, the wire axis Ustilago (Sphacelotheca reilinia) on the ‧ corn, Thielaviopsis mold (Thievaliopsis) on the ‧ soybeans and cotton genus, ‧ Tilletia genus on cereals, Ustilago genus on cereals, corn and sugar cane, and Venturia genus (melanosis) on apples and pears

The composition of the present invention is particularly effective against Sclerotinia sclerotiorum , Rhizoctonia solani , Streptomyces scabies , Phytophthora infestans , and Phytophthora infestans Fusarium oxysporum), fungal genus Pythium (Pythium spp.) and fungi Ceratocystis singular (Ceratocystis paradoxa) of infection.

The composition of the present invention is suitable for processing plants and plant matter in a wide range of crops, including (wheat, barley, rye, oats, corn, rice, sorghum, triticale, and related crops); beets (sugar beet or forage beet ); Fruits, such as pears, stone fruits and berries, such as apples, pears, plums, peaches, almonds, cherries, and raspberries such as strawberries, raspberries, and blackberries; legumes (beans, lentils, peas, soybeans); Oil plants (rapeseed, mustard, sunflower); melons (squash, cucumber, cantaloupe); fiber plants (cotton, flax, hemp, jute); citrus fruits such as orange, lemon, grapefruit and orange; vegetables ( Spinach, lettuce, asparagus, cabbage, carrots, onions, tomatoes, potatoes, red peppers; and ornamentals (flowers, shrubs, broad-leaved trees or evergreens such as conifers). The composition of the present invention is particularly suitable for soybean, cotton, dried beans, sugar cane, tomato, potato and rice.

The composition of the present invention may be contained, mixed or applied with other pesticides, such as other fungicides, insecticides and nematicides.

The rate of application (use) of the composition of the present invention varies, for example, according to the type used, the type of crop, the specific active ingredient in the composition, the type of plant to be treated, but the active ingredient in the composition can provide the desired Role (such as disease or pest control). The application rate of the composition for a specific setting condition can be easily determined through routine experimentation.

In general, the application rate can vary from 0.03 kg to 3 kg (kg / ha) of each active ingredient. Preferred application rates are component (A) from 10 to 500 g / ha; component (B) from 10 to 700 g / ha; and component (C) from 10 to 900 g / ha.

Components (A), (B), and (C), and any other pesticides, can be applied and used in pure form, such as solid active ingredients, for example, with a specific particle size, or preferably with at least one adjuvant Agents or adjuvant components, such as extenders, such as solvents or solid carriers, or interfacial active compounds (surfactants), are commonly applied and used, as is commonly used in formulation technology. More preferably, components (A), (B) and (C) are in the form of a formulation composition containing one or more of the aforementioned conventional formulation adjuvants.

As described above, the present invention provides a composition for treating plants, plant matter, or sites.

According to a further aspect, the present invention provides a method for preventing and / or combating fungal infections of plants, plant matter or places, the method comprising administering the plants, plant matter or places: (A) strobilurin; (B) benzimidazole; and (C) fugulimide.

The present invention also provides a method for preventing and / or combating fungal infections, in which a plant, one or more parts thereof (e.g., leaves or seeds) or sites are treated with each active ingredient component (A), (B), and (C) . The active ingredient components (A), (B) and (C) may be applied simultaneously, in any combination thereof, or continuously at short intervals, for example, on the same day, applied to plants, plant matter, or a place where control is desired. In a preferred embodiment, the active ingredient components (A), (B) and (C) are applied simultaneously to a plant, plant material or site. If administered separately, the active ingredients can be administered in any order.

The active ingredients (A), (B) and (C) may be administered in any suitable form as described above. Typically, the active ingredient is administered as a formulation, that is, it includes one or more active ingredients with additional carriers, surfactants, or other adjuvants that are used to enhance application in the formulation technology. In a preferred embodiment, the components (A), (B) and (C) are applied simultaneously, in particular as a composition according to the invention.

The active components (A), (B), and (C) can be applied to a plant, one or more parts thereof (such as leaves or seeds), or a site in any order as described above. Each compound can be administered only one or more times. Preferably, each of the active components (A), (B) and (C) is applied multiple times, in particular 2 to 5 times, more preferably 3 times.

The active components (A), (B) and (C) can be applied in any amount in proportion to each other to obtain an enhanced or synergistic combined effect. In particular, the relative amount applied to a plant, one or more parts thereof (such as leaves or seeds) or field is as described above, in which the ratio of any two components (A), (B) and (C) It is preferably between 25: 1 to 1:25, 20: 1 to 1:20 and 15: 1 to 1:15, more preferably 10: 1 to 1:10, 5: 1 to 1: 5 or 2.5: Within the range of 1 to 1: 2.5. The ratio of the component (A) to the component (B) in the composition may range from 1: 1 to 1:10, more preferably 1: 2 to 1: 8. The ratio of component (A) to component (C) may range from 1: 1 to 1: 6, more preferably 1: 1 to 1: 5. Similarly, the ratio of component (B) to component (C) in the composition may range from 1: 1 to 4: 1, and more preferably 1: 1 to 3: 1. In some specific embodiments, components (A), (B), and (C) are in a ratio of 1: 5: 3, 1: 5: 5, 1: 2: 1, 2: 7: 4, 2: 4 The weight ratio of: 3, 2: 8: 5, 1: 3: 2 or 1: 7: 3 is present in the composition.

In the case where the compounds (A), (B), and (C) are applied simultaneously in the present invention, they may be applied as a single composition containing components (A), (B), and (C). In these cases, the active components (A), (B), and (C) can be a single or separate formulation of each component composition and the formulations can be mixed together (such as a tank mix known in the art). , Ready-to-use, spray or slurry). Components (A), (B) and (C) can be combined with other pesticides as required. Alternatively, the active components (A), (B), and (C) can be provided from a single source of the compounding mixture, such as premixed, concentrated, compounded compounds (or products) known in the art. Furthermore, this single formulation can be mixed and combined with other pesticides as needed.

In one embodiment, the composition of the active ingredients (A), (B) and (C) applied by the method of the present invention is applied as a composition as described above. Therefore, the present invention provides a composition including active ingredients, components (A), (B), and (C) and other pesticides as needed, and one or more conventional formulation aids as detailed above as needed. This composition may be in the form of a tank mix or a premix composition.

Generally speaking, the tank mixing formulation comprises 0.1 to 20% by weight, especially 0.1 to 15% of the active ingredient compound, and 99.9 to 80%, especially 99.9 to 85% of one or more solid or liquid additives. Including, for example, solvents such as water. Auxiliaries, based on barrel mixing formulations, may include surfactants in an amount of 0 to 20%, especially 0.1 to 15% by weight.

Typically, premixed formulations include from 0.1 to 99.9% by weight, especially from 1 to 95% of the active ingredient compound, and from 99.9 to 0.1%, especially from 99 to 5%, solid or liquid adjuvants, including, for example, solvents Like water. The auxiliaries, based on the pre-mixed formulation, may include a surfactant in an amount of 0 to 50% by weight, especially 0.5 to 40%. This premix formulation is diluted or dispersed in a liquid carrier, especially water, before application and use.

In a preferred embodiment of the method of the present invention for treating or preventing a fungal infection, a combination of the following active ingredients (A), (B), and (C) is used: (A) attomin, (B) befentine , (C) Fustigmine; (A) Dioxystrobin, (B) Non-Ride, (C) Fustigmine; (A) Vanacid, (B) Mai Suining, (C) Fustilamine; (A) imidaclostrobin, (B) rot, (C) Fugillamine; (A) fluoxastrobin, (B) methyl doxorubicin (, (C) fugugilide; (A) g. Xin, (B) befentisole, (C) fugulimide; (A) fenoxystrobin, (B) befentisole, (C) fugulimide; (A) picoxystrobin, (B) rot, (C) fugemine; (A) Becmin, (B) befentin, (C) Fugemine; or (A) triflumin, B) befentinyl, (C) fugemine.

In one embodiment, the combinations of components (A), (B), and (C) described above are each provided in the form of a premix composition or a mixture.

The application rates of components (A), (B) and (C) in the method of the invention are as described above.

It should be understood that the reference of each component (A), (B) and (C) in the text is a reference to a single compound, or, if appropriate, a reference to more than one specific kind of active compound. Therefore, components (A) and (B) may be a single strobilurin compound or a mixture of two or more strobilurins. Similarly, component (B) may be a single benzimidazole or a mixture of two or more thereof.

Examples of the types of formulations used in the premix composition of the present invention are: EW: emulsion, oil-in-water ME: microemulsion SC: aqueous suspension FS: mobile suspension CS: aqueous capsule suspension OD: oil suspension, and SE: concentrated suspension emulsion WG: water-dispersible granules

The formulations of these compositions are known in the art and the components used in each formulation are commercially available. With these formulations, whether directly, that is, undiluted, or diluted with a suitable solvent, especially water, can treat plants, plant matter or places and protect against, for example, the harm of one or more pathogens. If appropriate, this treatment can be by spraying, pouring or soaking.

The active ingredient composition of the present invention is famous for the fact that it is well tolerated by plants and environmentally friendly.

The active ingredient compositions of the present invention are particularly advantageous for treating plants.

Aspects of the present invention are further described for the purpose of illustration only by the following specific examples included in the text.

Examples of formulations Example 1

Preparation of an aqueous suspension having the following composition:

The active ingredients (A), (B) and (C) which are ground into a fine powder are intimately mixed with the auxiliary component to obtain a suspension concentrate, whereby a suspension of any desired dilution can be obtained by dilution with water.

Alternatively, a suspension of the active ingredients and auxiliaries (including water) is wet-milled with a bead-mill to obtain a stable formulation containing properties suitable for treating plants or plant matter.

Example 2

Preparation of an aqueous suspension having the following composition:

The active ingredients (A), (B) and (C) which are ground into a fine powder are intimately mixed with the auxiliary component to obtain a suspension concentrate, whereby a suspension of any desired dilution can be obtained by dilution with water.

Alternatively, a suspension of active ingredients and auxiliaries (including water) is wet-milled with a bead mill to obtain a stable formulation suitable for treating plants or plant matter.

Example 3

Prepare a concentrated suspension with the following composition:

The active ingredient fugulimide (component (C)) is mixed with N-methylpyrrolidone, emulsifier OR / 36 and polymer stabilizer polyurethane, to form an oil phase.

The active ingredients attomin (component (A)) and befentin (component (B)) which are ground into fine powder are intimately mixed with other auxiliaries (including water) to obtain a mono-aqueous phase.

The oil phase is added to the water phase with continuous stirring for a sufficient time to form a stable emulsion.

Alternatively, the suspension of active ingredients and auxiliaries (including water) is wet-milled with a bead mill to obtain an aqueous phase. This water phase is combined with the oil phase to form a stable emulsion as described above.

Example 4

Prepare a concentrated suspension with the following composition:

The active ingredient epoxiconazole (component (A)) is mixed with N-methylpyrrolidone, emulsifier OR / 36 and polymer stabilizer polyurethane to form an oil phase.

The active ingredients Bacromin (component (B)) and befentin (component (C)) which are ground into fine powder are intimately mixed with other auxiliaries (including water) to obtain a mono-aqueous phase.

The oil phase is added to the water phase with continuous stirring for a sufficient time to form a stable emulsion.

Alternatively, the suspension of active ingredients and auxiliaries (including water) is wet-milled with a bead mill to obtain an aqueous phase. This water phase is combined with the oil phase to form a stable emulsion as described above.

Example 5

Preparation of an aqueous suspension having the following composition:

The active ingredients (A), (B) and (C), which are ground into fine powder, are intimately mixed with the auxiliary component to obtain a suspension concentrate, whereby a suspension of any desired dilution can be obtained by dilution with water.

Alternatively, a suspension of active ingredients and auxiliaries (including water) is wet-milled with a bead mill to obtain a stable formulation.

Example 6

Prepare an oil suspension with the following composition:

The active ingredients (A), (B) and (C), which are ground into fine powder, are intimately mixed with the auxiliary component to obtain a suspension concentrate, whereby a suspension of any desired dilution can be obtained by dilution with water.

Example 7

Prepare a mobile suspension with the following composition:

The active ingredients (A), (B) and (C) and the auxiliary components which are ground into fine powder are ground in a sand mill to obtain a flowing suspension with an average particle size of about 3 mm.

Example 8

Prepare a mobile suspension with the following composition:

The active ingredients (A), (B) and (C), which are ground into fine powder, and the auxiliary are ground in a sand mill to obtain a flowing suspension with an average particle size of about 3 mm.

Example 9

Preparation of water-dispersible granules having the following composition:

The active ingredients (A), (B) and (C) are thoroughly mixed and ground with an auxiliary agent in a fixed-rotor mill, and water-dispersible particles are prepared by extrusion. Dilution with water gives a stable dispersion or solution of the active compound.

By diluting the dispersible granules with an appropriate amount of water, an aqueous suspension of the desired concentration is obtained.

Example 10

Prepare a mobile suspension with the following composition:

The active ingredients (A), (B) and (C), which are ground into fine powder, and the auxiliary are ground in a sand mill to obtain a flowing suspension with an average particle size of about 3 mm.

Biological examples Field Test 1-Effectiveness against Sclerotinia sclerotiorum

Soybean plant young plants were sprayed with conidia suspensions of white mold (sclerotinia sclerotiorum) and cultured at 20 ° C and 100% relative atmospheric humidity for 48 hours.

The plants were then grouped and the individual groups were each subtomin 250g / L SC (Amistar® from Syngenta), Biocmin 250g / L SC (Headline® from BASF), and trifluoromin 500g / L SC (Gem ^TM from Bayer) 5. Befendrine was sprayed with 500g / kg WG (Bavistin® from BASF) and Fugillamine 500g / L SC (Nando® from Nufarm) for comparison purposes. Additional plant groups were treated with the formulations of Examples 1 to 10 above. Leave a group of untreated plants as a control group.

After being left in a greenhouse at 15 ° C and 80% relative atmospheric humidity for 15 days, the fungicidal effect was evaluated. The series of evaluation results are shown in Table A below, where 100% indicates that no fungal infection was observed and 0% is equivalent to the control group.

Field Test 2-Effects of Resistance to Rhizoctonia solani on Dry Beans

The dried bean plant young plants were sprayed with conidia suspension of Rhizoctonia solani, and cultured at 20 ° C and 100% relative atmospheric humidity for 48 hours.

The plants were then grouped and the individual groups were each subtomin 250g / L SC (Amistar® from Syngenta), Biocmin 250g / L SC (Headline® from BASF), and trifluoromin 500g / L SC (Gem ^TM from Bayer) 5. Befendrine was sprayed with 500g / kg WG (Bavistin® from BASF) and Fugillamine 500g / L SC (Nando® from Nufarm) for comparison purposes. Additional plant groups were treated with the formulations of Examples 1 to 10 above. Leave a group of untreated plants as a control group.

After being left in a greenhouse at 15 ° C and 80% relative atmospheric humidity for 15 days, the fungicidal effect was evaluated. The series of evaluation results are shown in Table B below, where 100% indicates that no fungal infection was observed and 0% is equivalent to the control group.

Field Test on utility of anti-scabies bacteria 3- (Srreptomyces scabies) of

The potato seed potatoes were sprayed with a conidia suspension of scab fungus and cultured at 20 ° C and 100% relative atmospheric humidity for 48 hours.

The plants were then grouped and the individual groups were each subtomin 250g / L SC (Amistar® from Syngenta), Biocmin 250g / L SC (Headline® from BASF), and trifluoromin 500g / L SC (Gem ^TM from Bayer) 5. Befendrine was sprayed with 500g / kg WG (Bavistin® from BASF) and Fugillamine 500g / L SC (Nando® from Nufarm) for comparison purposes. Additional plant groups were treated with the formulations of Examples 1 to 10 above. Leave a group of untreated plants as a control group.

After being left in a greenhouse at 15 ° C and 80% relative atmospheric humidity for 15 days, the fungicidal effect was evaluated. The series of evaluation results are shown in Table C below, where 100% indicates that no fungal infection was observed and 0% is equivalent to the control group.

Field trials on anti-Phytophthora infestans 4- (Phytophthora infestans) of Utility

The tomato plant young plants were sprayed with a conidia suspension of Phytophthora infestans and cultured at 20 ° C and 100% relative atmospheric humidity for 48 hours.

The plants were then grouped and the individual groups were each subtomin 250g / L SC (Amistar® from Syngenta), Biocmin 250g / L SC (Headline® from BASF), and trifluoromin 500g / L SC (Gem ^TM from Bayer) 5. Befendrine was sprayed with 500g / kg WG (Bavistin® from BASF) and Fugillamine 500g / L SC (Nando® from Nufarm) for comparison purposes. Additional plant groups were treated with the formulations of Examples 1 to 10 above. Leave a group of untreated plants as a control group.

After being left in a greenhouse at 15 ° C and 80% relative atmospheric humidity for 7 days, the fungicidal effect was evaluated. The series of evaluation results are set out in Table D below, where 100% indicates that no fungal infection was observed and 0% is equivalent to the control group.

5- sugarcane Field trials on anti-fungus Ceratocystis singular (Ceratocystis paradoxa) of utility

The sugarcane bud segments were sprayed with a conidia suspension of Saccharomyces singularis and cultured at 20 ° C and 100% relative atmospheric humidity for 48 hours.

The plants were then grouped and the individual groups were each subatom 250g / L SC (Amistar® from Syngenta), 100gmin 250g / L SC (Head1ine® from BASF), trifluoromin 500g / L SC (Gem ^TM from Bayer) 5. Befendrine was sprayed with 500g / kg WG (Bavistin® from BASF) and Fugillamine 500g / L SC (Nando® from Nufarm) for comparison purposes. Additional plant groups were treated with the formulations of Examples 1 to 10 above. Leave a group of untreated plants as a control group.

After being left in a greenhouse at 15 ° C and 80% relative atmospheric humidity for 15 days, the fungicidal effect was evaluated. The series of evaluation results are shown in Table E below, where 100% indicates that no fungal infection was observed and 0% is equivalent to the control group.

Field Test 6- Effectiveness against Fusarium oxysporum

Young cotton plants were sprayed with a conidia suspension of Fusarium oxysporum and cultured at 20 ° C and 100% relative atmospheric humidity for 48 hours.

The plants were then grouped and the individual groups were each subtomin 250g / L SC (Amistar® from Syngenta), Biocmin 250g / L SC (Headline® from BASF), and trifluoromin 500g / L SC (Gem ^TM from Bayer) 5. Befendrine was sprayed with 500g / kg WG (Bavistin® from BASF) and Fugillamine 500g / L SC (Nando® from Nufarm) for comparison purposes. Additional plant groups were treated with the formulations of Examples 1 to 10 above. Leave a group of untreated plants as a control group.

After being left in a greenhouse at 15 ° C and 80% relative atmospheric humidity for 15 days, the fungicidal effect was evaluated. The series of evaluation results are shown in Table F below, where 100% indicates that no fungal infection was observed and 0% is equivalent to the control group.

The above-mentioned data results of Tables A to F verify the effectiveness of the composition and method of the present invention, and especially achieve favorable synergistic effects by combining the components (A), (B) and (C) on the target plants.

Claims (15)

A fungicidal composition comprising a combination of the following fungicidal active ingredients: (A) azoxystrobin, (B) carbendazim, (C) fluazinam; (A) Dimoxystrobin, (B) benomyl, (C) fluazinam, (A) picoxystrobin, (B) thiabendazole, (C) Fluazinam; (A) pyraclostrobin, (B) carbendazim, (C) fluazinam; or (A) trifloxystrobin, (B) Carbendazim, (C) fluazinam; and the weight ratio of any two components (A), (B) and (C) is from 25: 1 to 1:25. For example, the fungicidal composition according to item 1 of the application, wherein component (A) is present in an amount of from 1 to 50% by weight. For example, the fungicidal composition according to item 1 of the patent application range, wherein component (B) is present in an amount of from 1 to 70% by weight. For example, the fungicidal composition according to item 1 of the application, wherein component (C) is present in an amount of from 1 to 90% by weight. For example, the fungicidal composition of the first patent application range, wherein the weight ratio of component (A) to component (B) is from 1: 1 to 1:10. For example, the fungicidal composition of item 1 of the patent scope, wherein the weight ratio of component (A) to component (C) is from 1: 1 to 1: 6. For example, the fungicidal composition of item 1 of the patent application scope, wherein the weight ratio of component (B) to component (C) is from 1: 1 to 1: 4. For example, the fungicidal composition of the first patent application range, wherein the weight ratio of components (A), (B) and (C) is selected from 1: 5: 3, 1: 5: 5, 1: 2: 1 , 2: 7: 4, 2: 4: 3, 2: 8: 5, 1: 3: 2 or 1: 7: 3. For example, the fungicidal composition of the scope of application for patent No. 1 further includes one or more auxiliary agents selected from the group consisting of: surfactants, polymer stabilizers, defoamers, organic solvents, preservatives, anti- Oxidant and thickener. A use of a fungicidal composition as claimed in any one of claims 1 to 9 for preventing and / or combating plant fungal infections. A method for protecting a plant against a fungal infection, comprising administering a fungicidal composition as described in any one of claims 1 to 9 of a patent application by applying to a plant, one or more parts thereof, or a place thereof. For example, the method of claim 11 in which the components (A), (B) and (C) are applied simultaneously. For example, the method of claim 11 in which the plant is soybean, cotton, dried beans, sugar cane, tomato, potato or rice. For example, the method of applying for item 11 of the patent scope, wherein the infection is Sclerotinia sclerotiorum , Rhizoctonia solani , Streptomyces scabies , Phytophthora infestans , Phytophthora infestans (Fusarium oxysporum) Fusarium, the genus Pythium infection (Pythium spp.) or singular bacteria Ceratocystis (Ceratocystis paradoxa) of. A plant protection product includes the fungicidal composition as described in any one of claims 1 to 9 of the scope of patent application.