TWI418338B - Brainwave monitoring device during sleeping - Google Patents
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本發明係有關於一種睡眠腦波監測裝置,尤其是一種能藉由即時監控並分析使用者之睡眠腦波訊號,而達到使用者睡眠之健康管理之睡眠腦波監測裝置。The invention relates to a sleep brain wave monitoring device, in particular to a sleep brain wave monitoring device capable of achieving health management of a user's sleep by monitoring and analyzing a user's sleep brain wave signal in real time.
許多民眾皆有睡眠品質不佳之問題,為了解決此現象,醫護人員常需收集患者之睡眠腦波,並採用離線的方式加以分析,方能了解患者之睡眠情形及其品質。然而,這樣的方式需耗費額外的判讀時間,同時對於醫療人員的診斷亦造成困擾。此外,傳統之離線腦波判讀方式不但具有耗費額外判讀時間之缺點,亦由於無法即時判讀患者之腦波訊號,因此無法即時反應患者之睡眠情形並即時施以相對措施。因此,有可能因無法針對使用者之睡眠情形即時調整相應之醫療處置,而導致患者之醫療品質降低,甚至損害患者之健康。Many people have problems with poor sleep quality. In order to solve this problem, medical staff often need to collect the sleep brainwaves of patients and analyze them offline to understand the sleep situation and quality of patients. However, such an approach requires additional interpretation time and is also plagued by the diagnosis of medical personnel. In addition, the traditional off-line brainwave interpretation method not only has the disadvantage of extra interpretation time, but also cannot immediately respond to the patient's sleep wave condition, and therefore can not immediately respond to the patient's sleep situation and immediately apply relative measures. Therefore, it may be impossible to immediately adjust the corresponding medical treatment for the user's sleep situation, resulting in a decrease in the medical quality of the patient and even impairing the health of the patient.
基於上述問題,需要一種能藉由即時監控並分析患者之腦波訊號,而判斷其睡眠品質之睡眠腦波監測裝置。Based on the above problems, there is a need for a sleep brainwave monitoring device capable of judging the sleep quality of a patient by immediately monitoring and analyzing the brain wave signal of the patient.
本發明係提供一種睡眠腦波監測裝置,其主要係藉由即時監控並分析患者睡眠時之腦波訊號而可供迅速調整後續之醫療作業內容,並省略藉由專業人員離線分析腦波的繁瑣作業,達到增進腦波判讀之效率及方便性等功效,為其發明目的。The invention provides a sleep brain wave monitoring device, which can quickly adjust the subsequent medical work content by monitoring and analyzing the brain wave signal of the patient during sleep, and omitting the cumbersome analysis of brain waves by professionals. Homework, to achieve the efficiency and convenience of brain wave interpretation, for its purpose.
此外,由於本發明之該睡眠腦波監測裝置係為一可攜式裝置,因此可使病患在家自行使用,達到病患自我健康管理之功效,為其又一目的。In addition, since the sleep brain wave monitoring device of the present invention is a portable device, the patient can be used at home to achieve the effect of self-health management of the patient, and another purpose thereof.
為達到前述發明目的,本發明所運用之技術手段及藉由該技術手段所能達到之功效包含有:一種睡眠腦波監測裝置,包含一訊號感測模組和一運算模組。該訊號感測模組係供感測一判斷時間之一腦波訊號。該運算模組係耦接至該訊號感測模組,並包含一特徵值擷取單元、一腦波相位判斷單元、一運算單元和一訊號輸出埠。該特徵值擷取單元係計算該腦波訊號之至少一特徵值訊號。該腦波相位判斷單元係接收該至少一特徵值訊號,並藉著比較該至少一特徵值訊號與一比較門檻值來判斷該腦波訊號之一A相位訊號和一B相位訊號。該運算單元係判斷該腦波訊號於該A相位訊號和該B相位訊號之間切換的一腦波循環交替模式時間,並計算該腦波循環交替模式時間相對於該判斷時間之一腦波循環交替模式比值。該訊號輸出埠係耦接至該運算單元,以供輸出代表該腦波循環交替模式比值之一輸出訊號。In order to achieve the foregoing object, the technical means and the functions that can be achieved by the technical method include: a sleep brain wave monitoring device, comprising a signal sensing module and an operation module. The signal sensing module is for sensing a brain wave signal of a judgment time. The computing module is coupled to the signal sensing module and includes a feature value capturing unit, a brain wave phase determining unit, an arithmetic unit and a signal output port. The feature value extraction unit calculates at least one characteristic value signal of the brain wave signal. The brain wave phase determining unit receives the at least one feature value signal, and compares the at least one feature value signal with a comparison threshold value to determine one of the brain wave signal A phase signal and a B phase signal. The operation unit determines an electroencephalogram cycle mode time in which the brain wave signal is switched between the A phase signal and the B phase signal, and calculates an electroencephalogram cycle in which the brain wave cycle alternate mode time is relative to the judgment time. Alternate mode ratio. The signal output system is coupled to the arithmetic unit for outputting an output signal representing one of the brain wave cyclic alternating mode ratios.
為讓本發明之上述及其他目的、特徵及優點能更明顯易懂,下文特舉本發明之較佳實施例,並配合所附圖式,作詳細說明如下:請參照第1圖,其係繪示根據本發明一較佳實施例所述之一睡眠腦波監測裝置的方塊圖。該睡眠腦波監測裝置較佳係為一可攜式裝置,並包含一訊號感測模組1、一運算模組2、一顯示單元3和一儲存單元4,其中運算模組2包含一切割單元21、一特徵值擷取單元22、一腦波相位判斷單元23、一運算單元24及一訊號輸出埠25。訊號感測模組1係耦接至運算模組2之切割單元21。運算模組2之切割單元21、特徵值擷取單元22、腦波相位判斷單元23、運算單元24及訊號輸出埠25係串聯耦接於訊號感測模組1及顯示單元3之間。儲存單元4係亦耦接至運算模組2之訊號輸出埠25,且儲存單元4可為一記憶卡(SD card)、一快閃記憶體(Flash Memory)、一硬碟(Hard Drive)或一光儲存媒體(Optical Storage)等等。The above and other objects, features and advantages of the present invention will become more <RTIgt; A block diagram of a sleep brainwave monitoring device in accordance with a preferred embodiment of the present invention is shown. The sleep brain wave monitoring device is preferably a portable device, and includes a signal sensing module 1, a computing module 2, a display unit 3 and a storage unit 4, wherein the computing module 2 comprises a cutting The unit 21, a feature value capturing unit 22, an electroencephalogram phase determining unit 23, an arithmetic unit 24, and a signal output port 25. The signal sensing module 1 is coupled to the cutting unit 21 of the computing module 2 . The cutting unit 21, the feature value capturing unit 22, the brain wave phase determining unit 23, the computing unit 24, and the signal output port 25 of the computing module 2 are coupled in series between the signal sensing module 1 and the display unit 3. The storage unit 4 is also coupled to the signal output port 25 of the computing module 2, and the storage unit 4 can be a memory card (SD card), a flash memory (Flash memory), a hard disk (Hard Drive) or An optical storage medium (Optical Storage) and so on.
訊號感測模組1係感測一使用者處於睡眠狀態時,於一判斷時間內之腦波訊號,並將此腦波訊號傳送至運算模組2之切割單元21。其中,訊號感測模組1之結構及藉其感測腦波之方法係為本領域熟悉該技藝者所可以理解。此外,使用者之睡眠狀態可區分為四個階段,第一和第二睡眠階段之淺睡期、第三睡眠階段之深睡期和第四睡眠階段之熟睡期,該判斷時間可處於任一上述四睡眠階段之期間。The signal sensing module 1 senses a brain wave signal during a judgment time when the user is in a sleep state, and transmits the brain wave signal to the cutting unit 21 of the computing module 2. The structure of the signal sensing module 1 and the method by which the brain wave is sensed are understood by those skilled in the art. In addition, the sleep state of the user can be divided into four stages, a shallow sleep period of the first and second sleep stages, a deep sleep period of the third sleep stage, and a sleep period of the fourth sleep stage, and the judgment time can be any During the above four sleep stages.
運算模組2之切割單元21係供接收該判斷時間內之該腦波訊號,將該判斷時間切割為數個單位時間,並依序將各該單位時間內之腦波訊號送至特徵值擷取單元22,以便運算模組2對每一該單位時間內的該腦波訊號個別進行處理。該單位時間之長度較佳係為0.4秒(但並不以此為限),且相鄰之二單位時間可具有時間重疊,其較佳係為該單位時間之50%。舉例來說,假設該判斷時間為一小時,且每個單位時間之長度為0.4秒,則切割單元21將該判斷時間切割為17999個單位時間,且相鄰之二單位時間具有50%之時間重疊(亦即0.2秒)。The cutting unit 21 of the computing module 2 is configured to receive the brain wave signal within the determining time, cut the determining time into a plurality of unit time, and sequentially send the brain wave signals in the unit time to the feature value capture. The unit 22 is configured such that the computing module 2 processes the brain wave signals individually for each unit time. The length of the unit time is preferably 0.4 seconds (but not limited thereto), and the adjacent unit time may have a time overlap, which is preferably 50% of the unit time. For example, if the judgment time is one hour and the length of each unit time is 0.4 seconds, the cutting unit 21 cuts the judgment time into 17999 unit time, and the adjacent two unit time has 50% time. Overlap (ie 0.2 seconds).
特徵值擷取單元22分別為各該單位時間之該腦波訊號計算一特徵值訊號。其中,該特徵值訊號係可為該腦波訊號在該單位時間內之平均值、平均絕對誤差、均方根值、變異數、標準差或上述各數值之任意組合。亦即,針對任一單位時間,特徵值擷取單元22係計算此一單位時間之特徵值訊號。The feature value capturing unit 22 calculates a feature value signal for each brain wave signal of the unit time. The characteristic value signal may be an average value, an average absolute error, a root mean square value, a variance number, a standard deviation, or any combination of the above values of the brain wave signal in the unit time. That is, for any unit time, the feature value extracting unit 22 calculates the feature value signal of the unit time.
腦波相位判斷單元23係對應於該特徵值訊號之取值方式預先設定一比較門檻值TH,且當該特徵值訊號大於該比較門檻值TH時,腦波相位判斷單元23判斷該單位時間內之該腦波訊號係為一A相位訊號;反之,當該特徵值訊號小於該比較門檻值TH時,腦波相位判斷單元23判斷該特定單位時間之該腦波訊號係為一B相位訊號。詳言之,該比較門檻值TH係可根據以下公式計算:比較門檻值TH=該判斷時間所處之睡眠階段之該腦波訊號的一特徵門檻+K*該判斷時間所處之睡眠階段之該腦波訊號的一變異特徵。The brain wave phase determining unit 23 presets a comparison threshold TH corresponding to the value of the feature value signal, and when the feature value signal is greater than the comparison threshold TH, the brain wave phase determining unit 23 determines the unit time The brain wave signal is an A phase signal; otherwise, when the eigenvalue signal is less than the comparison threshold TH, the brain wave phase determining unit 23 determines that the brain wave signal of the specific unit time is a B phase signal. In detail, the comparison threshold TH can be calculated according to the following formula: the comparison threshold TH = a characteristic threshold of the brain wave signal in the sleep stage in which the judgment time is located + K * the sleep stage in which the judgment time is located A variant of the brainwave signal.
其中,該特徵門檻之取值方式係與該特徵值訊號類似,皆可為該腦波訊號在特定睡眠階段之平均值、平均絕對誤差、均方根值、變異數、標準差或上述各數值之任意組合等等。舉例來說,在一實施方式中,假設該判斷時間係處於第三睡眠階段之深睡期,則藉由先前已記錄之前一次睡眠過程中的腦波訊號,可使用該使用者之第三睡眠階段的腦波訊號來決定該特徵門檻,且該特徵門檻係為第三睡眠階段之所有腦波訊號之平均值、平均絕對誤差、均方根值、變異數、標準差或上述各數值之任意組合等等。或者,在另一實施方式中,若欲針對該第三睡眠階段之深睡期之內的判斷時間進行判斷,但無該使用者先前已記錄之前一次睡眠過程中的腦波訊號可供參考,即可預先設定時間長度小於該判斷時間之一預定時間,以該預定時間內之腦波訊號的平均值、平均絕對誤差、均方根值、變異數、標準差或其任意組合等當成該特徵門檻。The value threshold of the feature is similar to the feature value signal, and may be an average value, an average absolute error, a root mean square value, a variance, a standard deviation, or the above values of the brain wave signal in a specific sleep stage. Any combination and so on. For example, in an embodiment, if the judgment time is in the deep sleep period of the third sleep stage, the third sleep of the user can be used by previously recording the brain wave signal during the previous sleep process. The brain wave signal of the stage determines the threshold of the feature, and the threshold of the feature is the average value, the average absolute error, the root mean square value, the variation number, the standard deviation or any of the above values of all brain wave signals in the third sleep stage. Combination and so on. Or, in another embodiment, if the judgment time within the deep sleep period of the third sleep stage is to be determined, but the user has not previously recorded the brain wave signal in the previous sleep process for reference, The predetermined length of time is less than a predetermined time of the determination time, and the average value, the average absolute error, the root mean square value, the variance, the standard deviation, or any combination thereof of the brain wave signal within the predetermined time is regarded as the feature. threshold.
在上述比較門檻值TH的公式中,K為一變異特徵係數,其值對應於第一和二睡眠階段係設為1,對應於第三睡眠階段係設為1.5,以及對應於第四睡眠階段係設為2。此外,該腦波訊號之變異特徵係可透過標準差、變異數、或其他可代表該腦波訊號之變異特性的特徵訊號求得。據此,腦波相位判斷單元23逐一判斷各該單位時間之該腦波訊號的相位(屬於A相位訊號和B相位訊號),並將所判斷之結果送至運算單元24。請參照第2圖,其係繪示該使用者腦波訊號之一範例。在第2圖的範例中,位於該腦波訊號之一左方星號”*”與右方星號”*”中間的區段係為該A相位訊號,而位於此區段之外的腦波訊號係屬於該B相位訊號。In the above formula for comparing the threshold value TH, K is a variation characteristic coefficient whose value corresponds to the first and second sleep stages is set to 1, corresponding to the third sleep stage is set to 1.5, and corresponds to the fourth sleep stage. Set to 2. In addition, the variation characteristics of the brain wave signal can be obtained by standard deviation, variation number, or other characteristic signals representing the variation characteristics of the brain wave signal. According to this, the electroencephalogram phase judging unit 23 judges the phases of the electroencephalogram signals (which belong to the A phase signal and the B phase signal) for each unit time one by one, and sends the result of the judgment to the arithmetic unit 24. Please refer to FIG. 2, which shows an example of the brainwave signal of the user. In the example of FIG. 2, the segment located between the left asterisk "*" and the right asterisk "*" of one of the brainwave signals is the A phase signal, and the brainwave signal outside the segment is It belongs to the B phase signal.
運算單元24係接收腦波相位判斷單元23之輸出結果,計算該判斷時間內之一腦波循環交替模式(Cyclic Alternating Pattern,CAP)時間(CAP time),並進一步計算該CAP時間相對於該判斷時間之百分比值以做為一腦波循環交替模式比值(CAP rate),最後再產生一輸出訊號由訊號輸出埠25輸出。詳言之,當該判斷時間內之各該單位時間之該腦波訊號的相位皆為已知之情況下,運算單元24計算獲得該CAP時間的方式較佳係如下所述。運算單元24首先進行一校正步驟,以檢閱任一B相位訊號的持續時間是否小於一調整時間,若結果為「是」即將此一B相位訊號的判斷結果調整為A相位訊號。其中,該調整時間係供根據習知之腦波訊號之規律性調整腦波相位判斷單元23之誤判結果,且該調整時間之長度較佳係選擇為2秒。繼之,運算單元24進行一循環交替模式判斷步驟,其係判斷各該B相位訊號的持續時間是否小於一標準時間,若此判斷結果為「是」即將前一A相位訊號及該B相位訊號的總持續時間定義為一相位交替時間;而若此判斷結果為「否」,則將前一A相位訊號之持續時間及該標準時間定義為該相位交替時間,其中該標準時間較佳係設定為60秒。藉此,運算單元24即可將該判斷時間內的所有相位交替時間進行加總而獲得該CAP時間。最後,再將該CAP時間除以該判斷時間以取得該CAP比值。此外,該訊號輸出埠25所輸出之輸出訊號即表示該CAP比值,且該CAP比值之高低代表該使用者之睡眠的深淺程度。詳言之,一般而言,當該CAP比值高於40%時,代表該使用者處於較淺的睡眠狀態中;反之,當該CAP比值低於40%時,即代表該使用者處於較深沉的睡眠狀態中。The operation unit 24 receives the output result of the brain wave phase determining unit 23, calculates a Cyclic Alternating Pattern (CAP) time (CAP time), and further calculates the CAP time relative to the judgment. The percentage value of time is used as a CAP rate, and finally an output signal is outputted by the signal output 埠25. In detail, when the phase of the brain wave signal at each unit time in the judgment time is known, the manner in which the arithmetic unit 24 calculates the CAP time is preferably as follows. The operation unit 24 first performs a correction step to check whether the duration of any B phase signal is less than an adjustment time. If the result is YES, the judgment result of the B phase signal is adjusted to the A phase signal. The adjustment time is for adjusting the false positive result of the brain wave phase judging unit 23 according to the regularity of the conventional brain wave signal, and the length of the adjustment time is preferably selected to be 2 seconds. Then, the computing unit 24 performs a cyclic alternate mode determining step of determining whether the duration of each of the B phase signals is less than a standard time. If the determination result is "Yes", the previous A phase signal and the B phase signal are The total duration is defined as a phase alternation time; if the result of the determination is "NO", the duration of the previous A phase signal and the standard time are defined as the phase alternate time, wherein the standard time is preferably set. It is 60 seconds. Thereby, the arithmetic unit 24 can sum up all the phase alternate times in the determination time to obtain the CAP time. Finally, the CAP time is divided by the judgment time to obtain the CAP ratio. In addition, the output signal outputted by the signal output port 25 indicates the CAP ratio, and the level of the CAP ratio represents the degree of sleep of the user. In detail, in general, when the CAP ratio is higher than 40%, it means that the user is in a shallow sleep state; conversely, when the CAP ratio is lower than 40%, it means that the user is deeper. In the sleep state.
據此,任何連接於訊號輸出埠25的電子醫療儀器即可根據訊號輸出埠25之輸出訊號進行醫藥劑量或者醫學療程的調整,達到根據即時偵測之睡眠腦波迅速調整醫療內容之目的。舉例而言,當連接於訊號輸出埠25之電子醫療儀器為一正壓輔助呼吸裝置時,該正壓輔助呼吸裝置係可預設至少一氣壓輸出等級,以便在接收訊號輸出埠25之輸出訊號之後,對應於不同的腦波循環交替模式比例值輸出各種數值之氣壓。例如:當該腦波循環交替模式比例值較高時,即表示該使用者之睡眠狀態較淺,故該正壓輔助呼吸裝置可對應提高氣壓輸出等級,以增加輸出之氣壓值而促使該使用者再次回復至較為深沉的睡眠狀態。反之,當該的腦波循環交替模式比例值較低時,該正壓輔助呼吸裝置可對應降低氣壓輸出等級,以降低輸出之氣壓值,避免過度消耗該正壓輔助呼吸裝置之儲氧量。Accordingly, any electronic medical instrument connected to the signal output port 25 can adjust the medical dose or medical treatment according to the output signal of the signal output 埠25, so as to quickly adjust the medical content according to the sleep brainwave detected by the instant detection. For example, when the electronic medical device connected to the signal output port 25 is a positive pressure auxiliary breathing device, the positive pressure assisted breathing device can preset at least one air pressure output level to output the signal at the output signal output 25 Thereafter, the gas pressures of various values are output corresponding to different brain wave cycle alternating mode proportional values. For example, when the ratio of the brain wave circulation alternating mode is high, indicating that the user's sleep state is relatively shallow, the positive pressure assisted breathing apparatus can increase the air pressure output level to increase the output air pressure value to promote the use. The person returned to a deeper sleep state again. Conversely, when the ratio of the brain wave circulation alternating mode is low, the positive pressure assisted breathing apparatus can lower the air pressure output level to reduce the output air pressure value, and avoid excessively consuming the oxygen storage amount of the positive pressure auxiliary breathing apparatus.
此外,連接至訊號輸出埠25之顯示單元3係可接收該輸出訊號,並顯示運算單元24所計算獲得之腦波循環交替模式比例值。另,訊號感測模組1、腦波相位判斷單元23和運算單元24亦可耦接至顯示單元3和儲存單元4。如此一來,顯示單元3亦可顯示該腦波訊號之態樣、該A相位訊號和該B相位訊號之間的切換情形,以及該腦波循環交替模式比例值。同時,儲存單元4亦可儲存該腦波訊號之態樣、該A相位訊號和該B相位訊號之間的切換情形,以及該腦波循環交替模式比例值,以供後續進行其他醫療分析判斷之用。In addition, the display unit 3 connected to the signal output port 25 can receive the output signal and display the cerebro wave cyclic alternating mode ratio value calculated by the operation unit 24. In addition, the signal sensing module 1 , the brain wave phase determining unit 23 and the computing unit 24 may also be coupled to the display unit 3 and the storage unit 4 . In this way, the display unit 3 can also display the state of the brain wave signal, the switching situation between the A phase signal and the B phase signal, and the ratio of the brain wave cyclic alternating mode. At the same time, the storage unit 4 can also store the state of the brain wave signal, the switching situation between the A phase signal and the B phase signal, and the ratio of the brain wave cycle alternating mode for subsequent medical analysis and judgment. use.
根據本發明之該睡眠腦波監測裝置,可省略醫護人員需事後分析腦波的繁瑣作業,達到增進腦波判讀方便性之功效。此外,由於該睡眠腦波監測裝置係為一可攜式裝置,因此可使病患在家自行使用,達到病患自我健康管理之功效。According to the sleep brain wave monitoring device of the present invention, the cumbersome operation of the medical staff to analyze the brain waves afterwards can be omitted, and the effect of improving the convenience of brain wave interpretation can be achieved. In addition, since the sleep brain wave monitoring device is a portable device, the patient can be used at home to achieve the self-health management effect of the patient.
雖然本發明已利用上述較佳實施例揭示,然其並非用以限定本發明,任何熟習此技藝者在不脫離本發明之精神和範圍之內,相對上述實施例進行各種更動與修改仍屬本發明所保護之技術範疇,因此本發明之保護範圍當視後附之申請專利範圍所界定者為準。While the invention has been described in connection with the preferred embodiments described above, it is not intended to limit the scope of the invention. The technical scope of the invention is protected, and therefore the scope of the invention is defined by the scope of the appended claims.
1...訊號感測模組1. . . Signal sensing module
2...運算模組2. . . Computing module
21...切割單元twenty one. . . Cutting unit
22...特徵值擷取單元twenty two. . . Eigenvalue extraction unit
23...腦波相位判斷單元twenty three. . . Brain wave phase judgment unit
24...運算單元twenty four. . . Arithmetic unit
25...訊號輸出埠25. . . Signal output埠
3...顯示單元3. . . Display unit
4...儲存單元4. . . Storage unit
第1圖:本發明一較佳實施例所述之一睡眠腦波監測裝置的方塊圖。Figure 1 is a block diagram of a sleep brainwave monitoring device in accordance with a preferred embodiment of the present invention.
第2圖:本發明較佳實施例所述之一使用者腦波訊號之範例。Fig. 2 is a diagram showing an example of a user brain wave signal according to a preferred embodiment of the present invention.
1...訊號感測模組1. . . Signal sensing module
2...運算模組2. . . Computing module
21...切割單元twenty one. . . Cutting unit
22...特徵值擷取單元twenty two. . . Eigenvalue extraction unit
23...腦波相位判斷單元twenty three. . . Brain wave phase judgment unit
24...運算單元twenty four. . . Arithmetic unit
25...訊號輸出埠25. . . Signal output埠
3...顯示單元3. . . Display unit
4...儲存單元4. . . Storage unit
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