TWI494090B - Method for making antibacterial hemostatic dressing - Google Patents
Method for making antibacterial hemostatic dressing Download PDFInfo
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Description
本發明係有關於一種抗菌、止血敷料的製造方法,尤其是指一種同時具有抑制細菌及微生物生長和繁殖以及促進血液凝固反應之止血、抗菌敷料的製造方法。The present invention relates to a method for producing an antibacterial and hemostatic dressing, and more particularly to a method for producing a hemostatic and antibacterial dressing which simultaneously inhibits growth and reproduction of bacteria and microorganisms and promotes blood coagulation reaction.
在外科手術程序中,欲將流血、手術後併發症降到最低及欲縮短手術室中的手術時間,流血的控制為必需的。在各種外科手術程序中,包括神經外科手術、腹部手術、心血管手術、胸部手術、頭部與頸部手術、骨盆手術及皮膚與皮下組織…等手術,以敷料作為局部止血傷口之用途已行之有年。In the surgical procedure, bleeding control is necessary to minimize bleeding and post-operative complications and to shorten the operation time in the operating room. In various surgical procedures, including neurosurgery, abdominal surgery, cardiovascular surgery, chest surgery, head and neck surgery, pelvic surgery, and skin and subcutaneous tissue, etc., the use of dressing as a local hemostasis wound has been used. There are years.
由於手術過程或遭受意外傷害時,血管會因為破裂而大量流血;當失血量不超過人體內的總血量的10%,則透過身體的自我調節,便能很快恢復;如果失血量達總血量的20%時,將會出現脈搏加快,血壓下降等症狀;如果在短時間內喪失的血液達全身血液的30%或更多,就可能危及生命。因此,止血是臨床治療的重要部分,而有效的止血則是患者生命安全的必要保障。Due to the surgical procedure or accidental injury, the blood vessels will bleed a lot due to rupture; when the blood loss does not exceed 10% of the total blood volume in the human body, it can be quickly restored through self-regulation of the body; if the blood loss reaches the total amount At 20% of the blood volume, symptoms such as increased pulse rate and decreased blood pressure will occur; if the blood lost in a short period of time reaches 30% or more of the whole body blood, it may be life-threatening. Therefore, hemostasis is an important part of clinical treatment, and effective hemostasis is a necessary guarantee for the safety of patients.
傳統人為壓力止血法、燒灼處理或外傷縫合等止血處理方式,均相當耗時,而且未必能有效止血。因此近幾年來,一些局部的止血劑被開發用來控制因為手術或外傷性的出血;該止血劑在接觸到出血傷口面便促進血液凝固反應,迅速形成血栓,阻止出血情形。由此可知,止血技術已由過去單純的器械止血措施,發展為生物止血技術。Traditional hemostasis methods such as pressure hemostasis, cauterization or traumatic suture are quite time consuming and may not be effective in stopping bleeding. Therefore, in recent years, some local hemostatic agents have been developed to control bleeding due to surgery or trauma; the hemostatic agent promotes blood coagulation reaction upon contact with the bleeding wound surface, rapidly forming a thrombus and preventing bleeding. It can be seen that the hemostasis technology has evolved into a biological hemostasis technology from the simple instrumental hemostasis measures in the past.
今,本發明即是針對生物止血敷料之製程進行開發,以提升生產效率,降低生產成本。Nowadays, the present invention is developed for the process of biological hemostatic dressing to improve production efficiency and reduce production cost.
本發明之主要目的,係提供一種抗菌、止血敷料的製造方法,主要是透過一貫化的製造流程生產製造同時具有抑制細菌及微生物生長和繁殖以及促進血液凝固反應之止血、抗菌敷料的方法。The main object of the present invention is to provide a method for producing an antibacterial and hemostatic dressing, which is mainly a method for producing a hemostatic and antibacterial dressing which simultaneously inhibits growth and reproduction of bacteria and microorganisms and promotes blood coagulation reaction through a consistent manufacturing process.
上述本發明之主要目的與功效,是由以下之具體技術手段所達成:The above main objects and effects of the present invention are achieved by the following specific technical means:
一種抗菌、止血敷料的製造方法,包括分別進行抗菌膜層之製程與止血膜層之製程,以及抗菌膜層與止血膜層的對應接合;其中:The invention relates to a method for manufacturing an antibacterial and hemostatic dressing, comprising separately performing a process of an antibacterial film layer and a process of a hemostatic film layer, and a corresponding joint of the antibacterial film layer and the hemostatic film layer; wherein:
抗菌膜層之製程包括以下步驟:The process of the antibacterial film layer comprises the following steps:
步驟一:取一預設量之抗菌材料並置於受輸送帶連動傳送之第一離形紙上;Step 1: taking a predetermined amount of antibacterial material and placing it on the first release paper conveyed by the conveyor belt;
步驟二:於第一模具中設置第二離形紙;Step two: disposing a second release paper in the first mold;
步驟三:第一模具下壓第一離形紙上之抗菌材料,使抗菌材料散開並呈預設形狀;Step 3: The first mold presses the antibacterial material on the first release paper to disperse the antibacterial material and assume a preset shape;
步驟四:上抬第一模具,並進行烘乾抗菌材料,以形成抗菌膜層;Step 4: lifting the first mold and drying the antibacterial material to form an antibacterial film layer;
止血膜層之製程包括以下步驟:The process of the hemostatic layer includes the following steps:
步驟一:取一預設量之止血材料並置於受輸送帶連動傳送之第三離形紙上;Step 1: take a predetermined amount of hemostatic material and place it on the third release paper conveyed by the conveyor belt;
步驟二:於第二模具中設置第四離形紙;Step 2: disposing a fourth release paper in the second mold;
步驟三:第二模具下壓第三離形紙上之止血材料,使止血材料散開並呈預設形狀;Step 3: pressing the hemostatic material on the third release paper by the second mold, so that the hemostatic material is scattered and has a preset shape;
步驟四:上抬第二模具,並進行烘乾止血材料,以形成止血膜層;Step 4: lifting the second mold and drying the hemostatic material to form a hemostatic layer;
該抗菌膜層與止血膜層的對應接合包括以下步驟:The corresponding engagement of the antimicrobial membrane layer with the hemostatic membrane layer comprises the following steps:
步驟一:藉由機具將止血膜層對應置於抗菌膜層上;Step 1: placing the hemostatic membrane layer on the antibacterial film layer by means of an implement;
步驟二:於止血膜層上覆設第五離形紙;Step 2: coating a fifth release paper on the hemostatic membrane layer;
步驟三:以封壓模具下壓堆疊的止血膜層與抗菌膜層,使抗菌膜層與止血膜層貼合為一體,同時裁切第五離形紙與第一離形紙,完成由下而上依序為第一離形紙、抗菌膜層、止血膜層、第五離形紙之抗菌、止血敷料的製造。Step 3: Pressing the stacked hemostatic film layer and the antibacterial film layer under the sealing mold, so that the antibacterial film layer and the hemostatic film layer are integrated into one body, and the fifth release paper and the first release paper are cut at the same time, and the lowering is completed. The above is the manufacture of the first release paper, the antibacterial film layer, the hemostatic film layer, the antibacterial of the fifth release paper, and the hemostatic dressing.
如上所述之抗菌、止血敷料的製造方法,其中,抗菌膜層是採60度烘乾。The method for producing an antibacterial or hemostatic dressing as described above, wherein the antibacterial film layer is dried at 60 degrees.
如上所述之抗菌、止血敷料的製造方法,其中,抗菌膜層是烘乾至50%乾燥度。The method for producing an antibacterial or hemostatic dressing as described above, wherein the antibacterial film layer is dried to 50% dryness.
如上所述之抗菌、止血敷料的製造方法,其中,止血膜層是採60度烘乾。The method for producing an antibacterial or hemostatic dressing as described above, wherein the hemostatic membrane layer is dried at 60 degrees.
如上所述之抗菌、止血敷料的製造方法,其中,止血膜層是烘乾至50%乾燥度。The method for producing an antibacterial or hemostatic dressing as described above, wherein the hemostatic layer is dried to 50% dryness.
(A)...抗菌膜層之製程(A). . . Antibacterial film layer process
(B)...止血膜層之製程(B). . . Hemostatic membrane process
(C)...抗菌膜層與止血膜層的對應接合(C). . . Corresponding joint between antibacterial film layer and hemostatic film layer
(1)...抗菌膜層(1). . . Antibacterial film
(11)...抗菌材料(11). . . Antibacterial material
(12)...輸送帶(12). . . conveyor
(13)...第一離形紙(13). . . First release paper
(14)...第一模具(14). . . First mold
(15)...第二離形紙(15). . . Second release paper
(2)...止血膜層(2). . . Hemostatic layer
(21)...止血材料(twenty one). . . Hemostatic material
(22)...輸送帶(twenty two). . . conveyor
(23)...第三離形紙(twenty three). . . Third release paper
(24)...第二模具(twenty four). . . Second mold
(25)...第四離形紙(25). . . Fourth release paper
(3)...機具(3). . . Machine
(4)...第五離形紙(4). . . Fifth release paper
(5)...封壓模具(5). . . Sealing mold
第一圖:本發明抗菌、止血敷料的製造方法的立體流程示意圖First: Schematic diagram of the three-dimensional flow of the manufacturing method of the antibacterial and hemostatic dressing of the present invention
第二圖:本發明抗菌、止血敷料的製造方法的前視流程示意圖Second: Schematic diagram of the front view of the manufacturing method of the antibacterial and hemostatic dressing of the present invention
為令本發明所運用之技術內容、發明目的及其達成之功效有更完整且清楚的揭露,茲於下詳細說明之,並請一併參閱所揭之圖式及圖號:For a more complete and clear disclosure of the technical content, the purpose of the invention and the effects thereof achieved by the present invention, it is explained in detail below, and please refer to the drawings and drawings:
請參看第一、二圖所示,其係分別揭示本發明之抗菌、止血敷料的製造方法的立體流程示意圖與前視流程示意圖。Please refer to the first and second figures, which respectively disclose a three-dimensional flow diagram and a front view flow diagram of the method for manufacturing the antibacterial and hemostatic dressing of the present invention.
本發明之抗菌、止血敷料的製造方法,係包括分別進行的抗菌膜層之製程(A)與止血膜層之製程(B),以及抗菌膜層與止血膜層的對應接合製程(C);其中:The method for producing an antibacterial and hemostatic dressing of the present invention comprises the process (A) of the antibacterial film layer and the process (B) of the hemostatic film layer respectively, and the corresponding bonding process (C) of the antibacterial film layer and the hemostatic film layer; among them:
該抗菌膜層之製程(A)包括以下步驟:The process (A) of the antibacterial film layer comprises the following steps:
步驟一:取一預設量之抗菌材料(11)並置於受輸送帶(12)連動傳送之第一離形紙(13)上;Step 1: taking a predetermined amount of antibacterial material (11) and placing it on the first release paper (13) conveyed by the conveyor belt (12);
步驟二:於第一模具(14)中設置第二離形紙(15);Step 2: providing a second release paper (15) in the first mold (14);
步驟三:第一模具(14)下壓第一離形紙(13)上之抗菌材料(11),使抗菌材料(11)散開並呈預設形狀;Step 3: The first mold (14) presses the antibacterial material (11) on the first release paper (13) to spread the antibacterial material (11) and assume a preset shape;
步驟四:上抬第一模具(14),並進行烘乾抗菌材料(11),以形成抗菌膜層(1);Step 4: lifting the first mold (14), and drying the antibacterial material (11) to form an antibacterial film layer (1);
止血膜層之製程(B)包括以下步驟:The process of the hemostatic layer (B) includes the following steps:
步驟一:取一預設量之止血材料(21)並置於受輸送帶(22)連動傳送之第三離形紙(23)上;Step 1: taking a predetermined amount of hemostatic material (21) and placing it on the third release paper (23) conveyed by the conveyor belt (22);
步驟二:於第二模具(24)中設置第四離形紙(25);Step 2: providing a fourth release paper (25) in the second mold (24);
步驟三:第二模具(24)下壓第三離形紙(23)上之止血材料(21),使止血材料(21)散開並呈預設形狀;Step 3: The second mold (24) presses the hemostatic material (21) on the third release paper (23) to spread the hemostatic material (21) and assume a preset shape;
步驟四:上抬第二模具(24),並進行烘乾止血材料(21),以形成止血膜層(2);Step 4: lifting the second mold (24), and drying the hemostatic material (21) to form a hemostatic layer (2);
該抗菌膜層與止血膜層的對應接合製程(C)包括以下步驟:The corresponding bonding process (C) of the antibacterial film layer and the hemostatic film layer comprises the following steps:
步驟一:藉由機具(3)將止血膜層(2)對應置於抗菌膜層(1)上;Step 1: The hemostatic film layer (2) is correspondingly placed on the antibacterial film layer (1) by the implement (3);
步驟二:於止血膜層(2)上覆設第五離形紙(4);Step 2: covering the hemostatic membrane layer (2) with a fifth release paper (4);
步驟三:以封壓模具(5)下壓堆疊的止血膜層(2)與抗菌膜層(1),使抗菌膜層(1)與止血膜層(2)貼合為一體,同時裁切第五離形紙(4)與第一離形紙(13),完成由下而上依序為第一離形紙(13)、抗菌膜層(1)、止血膜層(2)、第五離形紙(4)之抗菌、止血敷料的製造。Step 3: Pressing the stacked hemostatic membrane layer (2) and the antibacterial membrane layer (1) with a sealing mold (5), so that the antibacterial membrane layer (1) and the hemostatic membrane layer (2) are integrated into one body and cut at the same time. The fifth release paper (4) and the first release paper (13) are completed from bottom to top as the first release paper (13), the antibacterial film layer (1), the hemostatic film layer (2), The manufacture of antibacterial and hemostatic dressings for five release papers (4).
以下再進一步以實施例詳細說明抗菌膜層之製程(A)與止血膜層之製程(B),以及抗菌膜層與止血膜層的對應接合製程(C):Hereinafter, the process of the antibacterial film layer (A) and the process of the hemostatic film layer (B), and the corresponding bonding process of the antibacterial film layer and the hemostatic film layer (C) will be further described in detail by way of examples:
<該抗菌膜層之製程(A)><Process of the antibacterial film layer (A)>
步驟一:取一10g之抗菌材料(11)並置於受輸送帶(12)連動傳送之第一離形紙(13)上;Step 1: Take a 10g of antibacterial material (11) and place it on the first release paper (13) conveyed by the conveyor belt (12);
步驟二:於第一模具(14)中設置對應第一模具(14)尺寸之第二離形紙(15);Step 2: a second release paper (15) corresponding to the size of the first mold (14) is disposed in the first mold (14);
步驟三:第一模具(14)下壓第一離形紙(13)上之抗菌材料(11),使抗菌材料(11)往外散開並呈預設形狀;Step 3: The first mold (14) presses the antibacterial material (11) on the first release paper (13) to spread the antibacterial material (11) outward and assume a preset shape;
步驟四:上抬第一模具(14),並以60度對抗菌材料(11)進行烘乾,並烘乾至50%乾燥後,即形成抗菌膜層(1)。Step 4: Lifting the first mold (14), drying the antibacterial material (11) at 60 degrees, and drying to 50% drying, then forming an antibacterial film layer (1).
<止血膜層之製程(B)><Process of hemostatic membrane layer (B)>
步驟一:取10g之止血材料(21)並置於受輸送帶(22)連動傳送之第三離形紙(23)上;Step 1: Take 10g of hemostatic material (21) and place it on the third release paper (23) conveyed by the conveyor belt (22);
步驟二:於第二模具(24)中設置與第二模具(24)尺寸對應之第四離形紙(25);Step 2: a fourth release paper (25) corresponding to the size of the second mold (24) is disposed in the second mold (24);
步驟三:第二模具(24)下壓第三離形紙(23)上之止血材料(21),使止血材料(21)散開並呈預設形狀;Step 3: The second mold (24) presses the hemostatic material (21) on the third release paper (23) to spread the hemostatic material (21) and assume a preset shape;
步驟四:上抬第二模具(24),並以60度對止血材料(21)進行烘乾,並烘乾至50%乾燥度後,便形成止血膜層(2)。Step 4: Lifting the second mold (24), drying the hemostatic material (21) at 60 degrees, and drying to 50% dryness, then forming a hemostatic layer (2).
<該抗菌膜層與止血膜層的對應接合製程(C)><Corresponding bonding process of the antibacterial film layer and the hemostatic film layer (C)>
步驟一:藉由如機械手臂之機具(3)將止血膜層(2)對應置於抗菌膜層(1)上;Step 1: The hemostatic film layer (2) is correspondingly placed on the antibacterial film layer (1) by a robot (3);
步驟二:於止血膜層(2)上覆設第五離形紙(4);Step 2: covering the hemostatic membrane layer (2) with a fifth release paper (4);
步驟三:以封壓模具(5)下壓堆疊的止血膜層(2)與抗菌膜層(1),使抗菌膜層(1)與止血膜層(2)貼合為一體,同時裁切第五離形紙(4)與第一離形紙(13),便可完成抗菌、止血敷料的製造。Step 3: Pressing the stacked hemostatic membrane layer (2) and the antibacterial membrane layer (1) with a sealing mold (5), so that the antibacterial membrane layer (1) and the hemostatic membrane layer (2) are integrated into one body and cut at the same time. The fifth release paper (4) and the first release paper (13) can complete the manufacture of the antibacterial and hemostatic dressing.
以上所舉者僅係本發明之部份實施例,並非用以限制本發明,致依本發明之創意精神及特徵,稍加變化修飾而成者,亦應包括在本專利範圍之內。The above is only a part of the embodiments of the present invention, and is not intended to limit the present invention. It is intended to be included in the scope of the present invention.
綜上所述,本發明實施例確能達到所預期之使用功效,又其所揭露之具體技術手段,不僅未曾見諸於同類產品中,亦未曾公開於申請前,誠已完全符合專利法之規定與要求,爰依法提出發明專利之申請,懇請惠予審查,並賜准專利,則實感德便。In summary, the embodiments of the present invention can achieve the expected use efficiency, and the specific technical means disclosed therein have not been seen in similar products, nor have they been disclosed before the application, and have completely complied with the patent law. The regulations and requirements, the application for invention patents in accordance with the law, and the application for review, and the grant of patents, are truly sensible.
(A)...抗菌膜層之製程(A). . . Antibacterial film layer process
(B)...止血膜層之製程(B). . . Hemostatic membrane process
(C)...抗菌膜層與止血膜層的對應接合(C). . . Corresponding joint between antibacterial film layer and hemostatic film layer
(1)...抗菌膜層(1). . . Antibacterial film
(11)...抗菌材料(11). . . Antibacterial material
(12)...輸送帶(12). . . conveyor
(13)...第一離形紙(13). . . First release paper
(14)...第一模具(14). . . First mold
(2)...止血膜層(2). . . Hemostatic layer
(21)...止血材料(twenty one). . . Hemostatic material
(22)...輸送帶(twenty two). . . conveyor
(23)...第三離形紙(twenty three). . . Third release paper
(24)...第二模具(twenty four). . . Second mold
(3)...機具(3). . . Machine
(4)...第五離形紙(4). . . Fifth release paper
(5)...封壓模具(5). . . Sealing mold
Claims (5)
該抗菌膜層之製程包括以下步驟:
步驟一:取一預設量之抗菌材料並置於受輸送帶連動傳送之第一離形紙上;
步驟二:於第一模具中設置第二離形紙;
步驟三:第一模具下壓第一離形紙上之抗菌材料,使抗菌材料散開並呈預設形狀;
步驟四:上抬第一模具,並進行烘乾抗菌材料,以形成抗菌膜層;
止血膜層之製程包括以下步驟:
步驟一:取一預設量之止血材料並置於受輸送帶連動傳送之第三離形紙上;
步驟二:於第二模具中設置第四離形紙;
步驟三:第二模具下壓第三離形紙上之止血材料,使止血材料散開並呈預設形狀;
步驟四:上抬第二模具,並進行烘乾止血材料,以形成止血膜層;
該抗菌膜層與止血膜層的對應接合包括以下步驟:
步驟一:藉由機具將止血膜層對應置於抗菌膜層上;
步驟二:於止血膜層上覆設第五離形紙;
步驟三:以封壓模具下壓堆疊的止血膜層與抗菌膜層,使抗菌膜層與止血膜層貼合為一體,同時裁切第五離形紙與第一離形紙,完成由下而上依序為第一離形紙、抗菌膜層、止血膜層、第五離形紙之抗菌、止血敷料的製造。The method for manufacturing a hemostatic dressing comprises separately performing a process of the antibacterial film layer and a process of the hemostatic film layer, and a corresponding joint of the antibacterial film layer and the hemostatic film layer; wherein:
The process of the antibacterial film layer comprises the following steps:
Step 1: taking a predetermined amount of antibacterial material and placing it on the first release paper conveyed by the conveyor belt;
Step two: disposing a second release paper in the first mold;
Step 3: The first mold presses the antibacterial material on the first release paper to disperse the antibacterial material and assume a preset shape;
Step 4: lifting the first mold and drying the antibacterial material to form an antibacterial film layer;
The process of the hemostatic layer includes the following steps:
Step 1: take a predetermined amount of hemostatic material and place it on the third release paper conveyed by the conveyor belt;
Step 2: disposing a fourth release paper in the second mold;
Step 3: pressing the hemostatic material on the third release paper by the second mold, so that the hemostatic material is scattered and has a preset shape;
Step 4: lifting the second mold and drying the hemostatic material to form a hemostatic layer;
The corresponding engagement of the antimicrobial membrane layer with the hemostatic membrane layer comprises the following steps:
Step 1: placing the hemostatic membrane layer on the antibacterial film layer by means of an implement;
Step 2: coating a fifth release paper on the hemostatic membrane layer;
Step 3: Pressing the stacked hemostatic film layer and the antibacterial film layer under the sealing mold, so that the antibacterial film layer and the hemostatic film layer are integrated into one body, and the fifth release paper and the first release paper are cut at the same time, and the lowering is completed. The above is the manufacture of the first release paper, the antibacterial film layer, the hemostatic film layer, the antibacterial of the fifth release paper, and the hemostatic dressing.
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TW102118796A TWI494090B (en) | 2013-05-28 | 2013-05-28 | Method for making antibacterial hemostatic dressing |
CN201410175082.3A CN103933604B (en) | 2013-05-28 | 2014-04-29 | Method for preparing antibacterial and hemostatic dressing |
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TW102118796A TWI494090B (en) | 2013-05-28 | 2013-05-28 | Method for making antibacterial hemostatic dressing |
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CN109322062B (en) * | 2018-10-26 | 2021-02-02 | 大连民族大学 | 3D stacked multilayer electrospun fiber layer-by-layer spraying method |
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TW201235016A (en) * | 2010-12-15 | 2012-09-01 | Kci Licensing Inc | Foam dressing with integral porous film |
CN202505827U (en) * | 2012-03-30 | 2012-10-31 | 深圳市源兴纳米医药科技有限公司 | Hemostatic anti-inflammation antimicrobial applicator containing nano-silver |
CN101730515B (en) * | 2007-06-21 | 2013-04-24 | 株式会社元比金 | Method for producing hydrophilic foam dressing |
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CN2803323Y (en) * | 2005-06-14 | 2006-08-09 | 王乐信 | Transparent wound dressing |
US7645252B2 (en) * | 2006-05-16 | 2010-01-12 | Barbara Brooke Jennings-Spring | Body or plant part dressing |
CN201949387U (en) * | 2010-12-29 | 2011-08-31 | 山东华兴纺织集团有限公司 | Medical dressing with chitosan fibers |
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CN101730515B (en) * | 2007-06-21 | 2013-04-24 | 株式会社元比金 | Method for producing hydrophilic foam dressing |
TW201235016A (en) * | 2010-12-15 | 2012-09-01 | Kci Licensing Inc | Foam dressing with integral porous film |
CN202505827U (en) * | 2012-03-30 | 2012-10-31 | 深圳市源兴纳米医药科技有限公司 | Hemostatic anti-inflammation antimicrobial applicator containing nano-silver |
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