TWI323652B - - Google Patents

Description

I323652 VI. Description of the Invention: [Technical Field] The present invention relates to a non-invasive measurement method for measuring a wrist-wound arterial waveform using a piezoelectric sensor, and is particularly suitable for measuring heart rate variability and measuring Autonomic nerve function, personal identification, respiratory waveform and cough detection side 'home isolation, and hospital isolation. [Prior Art] Heart rate and blood pressure (systolic and diastolic blood pressure) are important physiological parameters of the human body. 'Generally obtained by conventional wrist or arm electronic blood pressure measurement' has become a must-have for home use due to its simple operation and reasonable price. One of the medical devices, but another important physiological parameter, namely the blood pressure wave type, still has no high accuracy, and the instrument system that is easy to operate can be utilized. Currently, electronic sphygmomanometers on the market only measure energy and display the Systolic Blood Pressure (the maximum value on the blood pressure wave) and the Diastolic Blood Pressure (the minimum value on the blood pressure wave). The wrist-type electronic sphygmomanometer usually includes a pumping pump, a deflation valve, a barometer, an air tube, a wristband with an air bag, a circuit module, and a housing. During the blood pressure measurement, the pump and the deflation valve cause the air bag to be pressurized and decompressed. At the same time, the pulse wave of the wrist and iliac artery passes through the air bag and is sent to the barometer. The soft and hard body on the circuit will then be barometer. Pulse signal is amplified, filtered and analyzed to calculate heart rate, systolic blood pressure and diastolic pressure (Diast〇iic)

Blood Pressure) 〇 In addition to heart rate, systolic blood pressure, and diastolic blood pressure, the definite arterial blood pressure waveform is also an important physiological parameter, and its clinical application will be described later. Although the above-mentioned existing blood pressure measurement technology can record the waveform of the brachial artery by a barometer, due to the material characteristics and geometric shape of the air bag, the original shape of the blood pressure wave cannot be completely transmitted to the air of the air bag, and The air bag is transmitted to the path of the barometer through the airway tube, and the blood pressure wave pattern is degraded (Dampening) and the intensity is weakened, resulting in the measured blood pressure waveform loss sensitivity (Sensitivity) and accuracy (Accuracy). In order to measure the more accurate radial artery waveform, the pulse instrument on the market adopts a round pressure sensor of about 5 mm diameter. The test is to fix the round pressure sensor above the wrist artery with tape or rubber band. Then connect the signal wire to the circuit board or the computer. Usually, the round pressure sensor is made of a resistive (Resistor-type) conductive material and is used with the stressor (9) (4).

The principle of Gauge is similar, and it contains components such as amplification circuit, temperature effect compensation, and linearization processing. When the resistive material is stressed, the amount of change in resistance, current, or voltage is proportional to the pressure, so the pressure can be recorded by this relationship. The above technique can accurately measure the details and prototype of the radial artery waveform under ideal conditions, but has the disadvantage of not accurately controlling the pressure of the circular pressure sensor fixed to the wrist surface. It has been found that the pressure of the circular pressure sensor fixed on the wrist surface is very important for measuring the pressure waveform. If the pressure is too light (for example, the above-mentioned prior art is only fixed with tape or rubber band), it is encountered. 1323652 》年> 月^/日科: 'When the three supervised wrists are thick, the radial artery is deep, or the pulse is weak, the pressure sensor cannot obtain a clear blood pressure waveform signal. If this pressure is too heavy, the blood flow to the radial artery is severely blocked, causing the measured blood pressure and distortion. In addition, due to factors such as the size of the wrist and the deep location of the radial artery, the circular pressure device must be grasped by a trained physician or caregiver to find the correct position of the artery and fixed. This kind of inconvenient operation is the second factor that the pulse diagnosis instrument or other similar equipment can not become the home medical equipment like the electronic A pressure gauge. There are many kinds of personal identification technologies, including facial image analysis and sound. Acoustic recognition, fingerprint identification, blood group analysis, eye part analysis, hair analysis, handwriting analysis, and more advanced DNA cell identification analysis. The inventors have found through experiments that the blood pressure wave pattern in the human body has a unique and unique characteristic due to differences in heart shape, myocardial structure, and arterial tree structure of each person, and can be used as a feature of personal identification. Although the arterial blood pressure wave type sometimes changes due to factors such as mood and environment (such as increased heart rate and increased blood pressure when nervous or angry), as long as the blood pressure waveform is normalized to the value of the jump value and the gray pressure value, the waveform is The characteristics tend to be stable and become personalized. The current standard instrument for measuring Heart Rate Variability (RV) and Aut〇n〇mic Nervous System (ANS) is an electrocardiograph (ECG, or EKG). The so-called heart 1323652. Rate variability refers to the rate of heart beat (ie, heart rate), in addition to static constants maintained at about 60-90 times per minute, which also hides some rules or irregular fluctuations. When measuring the heart rate and its variability with an electrocardiograph, first attach the electrode piece to the patient's hands and feet (and the chest), measure its continuous periodic ECG signal, and then measure the wave-wave spacing in the ECG fluctuation ( For example, if the RR pitch is the highest peak of the ECG, the parameter values of the heart rate and the heart rate variability can be further calculated by the number of the wave-wave spacing obtained. For example, the average of the series of wave-wave spacing is the heartbeat period (Period), and the reciprocal of the heartbeat cycle is the heart rate (HR); the standard deviation of the series of wave-wave spacing is the heart rate. Heart Rate Variability, and the wave-wave spacing data can also be converted to spectrum using the Fast Fourier Transform. With the help of this spectrum analysis, the total variability of heart rate variability (Total Power) can be divided into two components, generally called high frequency (0.15-0.4 Hz, HF) components and low frequency (Low - , Frequency, 0.04-0.15 Hz, LF). De Boer et al. (Hemodynamic Fluctuations and Baroreflex Sensitivity in Humans: A Beat-to-Beat Model.; American Journal of Physiology; 253: H680-H689; 1987) Heart Rate Variability, confirmed by animal and human experiments. That is, the standard deviation of the series of peak-lift spacings and its total variability (Total Power) represents the total activity of the autonomic nerve, the low frequency component represents the sympathetic function, the high frequency component represents the parasitic intersection 1323652, and the low frequency component and the high The ratio of frequency components (LF/HF) reflects the degree of autonomic nervous balance. Since autonomic nerves control many important activities of the human body, such as heartbeat, blood pressure, blood sugar, sleep, sweating and bronchial obliteration, it is extremely necessary to have a simple and inexpensive autonomic nerve function monitor. At present, the medical community uses an electrocardiograph to measure heart rate variability and autonomic nerve function, which is not only complicated (large instruments, special software, multiple electrodes, and the action of the subject is limited), and the cost is high (initial instruments) And software costs, follow-up training and electrode film costs). When a person breathes, due to the Spillover of the Respiratory Center to the Vasomotor Center, the overflow signal passes through the autonomic nervous system (Sympathetic Nerve and parasympathetic nerves). Para-Sympathetic Nerve)) Reflex mechanism, which causes the heart rate and cardiac contractility to increase and decrease regularly with the respiratory cycle, so accurately record the arterial blood pressure waveform and further calculate and analyze the heart rate changes. The respiratory rate and waveform are detected. In addition, the peak of arterial blood pressure (ie, the point corresponding to systolic blood pressure) and the trough (ie, the point corresponding to diastolic blood pressure) will also rise and fall with the respiratory cycle, which is medically known as arterial blood pressure breathing wave (Arterial Respiratory Waves). ). In addition to the above-mentioned factors of respiratory center signal transmission, the source of this blood pressure respiratory wave includes two other physiological mechanisms: (1) When inhaling, the diaphragm (Diaphragm) drops, showing negative pressure, and the blood vessels in the thoracic cavity return to the heart flow. Decreased, causing cardiac output 7 1323652 • (Cardiac Output) reduction and instantaneous decrease in blood pressure; (2) pressure changes in the thoracic vessels due to the diaphragm moving up and down, this change causes arterial blood pressure through the vascular pressure feedback mechanism (Baroreceptor Reflex) Rise and fall with respiratory rate (for the above physiological phenomena and principles, please refer to Textbook of Medical Physiology"> Authored by

Arthur C. Cuyton, Eighth Edition, W. B. Saunders Company, ISBN 0-7216-3087-1, 1991, Chapter 13). It can be seen from the above that by accurately recording the arterial blood pressure waveform, the rise and fall of the peak or trough can be analyzed to obtain the respiratory frequency and the waveform. Moreover, infectious disease prevention and medical care can be said to be an extremely important part of the medical system. For example, Severe Acute Respiratory Syndr〇me (SARS), which has been ravaging Asia in recent years, is the most effective strategy for quarantining patients and others because of the infection route through human-infected media. Other infectious diseases, whether transmitted through the air (such as tuberculosis) or blood and body fluids (AIDS, AIDS, etc.), how to reduce the close contact of patients (or suspected patients) with medical staff or family members, it can be said that the current medical community is deeply n Anatomy of the 'in the hospital isolation and monitoring side = the standard steps of the hospital before the target is to enter the isolation by the medical staff daily = body temperature, ^ jump and blood 4 times (for example - four times a day), and 3 diseases such as I Difficulty in sucking beer and coughing, etc.), this kind of monitoring:; s Xiqiao people are the main cause of infection. Therefore, if the physiological signal of the isolated patient can be self-enhanced, and the power field is transferred from the ward to the 4th station, the medical person can be reduced to the wood/origin. In the general infection 1323652 disease, the main symptoms include fever, palpitations, shortness of breath, cough, sneezing, abnormal blood pressure, etc. If combined with the non-invasive hand-ankle artery wave pattern technique of the present invention, the conventional body temperature measurement technique, and the conventional wireless or wired signal transmission technology, the isolated patient carries the wrist-type physiological monitor of the present invention ( After detailed, you can pass the physiological signal (including body temperature, heart rate, blood pressure, respiratory waveform, cough, etc.) out of the ward to achieve the goal of reducing close contact. In terms of home isolation monitoring, the biggest vulnerability of the SARS epidemic prevention in recent years is that people who need to be separated by their own homes are required to go out in violation of regulations. Another technical need for home isolation is to obtain physiological signals from isolated people on a regular basis (such as a mother-in-law) and keep abreast of the overall epidemic. At present, the practice of health institutions in various countries is to send people to the isolation of people's homes. However, this measure not only requires a lot of manpower, but also susceptible to contact infection. If combined with (1) non-invasive wrist blood pressure wave measurement technology, (2) personal identification technology, (3) respiratory wave technology ' and (4) cough detection technology; and conventional knowledge ( 1) body temperature measurement technology, (2) wireless or wired transmission technology, and (3) blood pressure measurement technology can periodically pass the physiological signals (such as body temperature, heart rate, blood pressure, cough, etc.) of isolated people from home Go to the hospital or the health authority's and prevent the people from going out (and not being able to replace others), and further count the number of people and their locations at any time, thus controlling the epidemic. As described above, when a person breathes normally, the blood pressure waveform exhibits a periodic up and down movement. However, if the person suddenly coughs or hits the nozzle, the blood pressure waveform is returned to a normal state when the cough or sneeze stops when the diaphragm and the chest cavity vibrate sharply. If you can analyze your blood pressure baseline (Baseline) and sudden change (Abrupt Change), you should be able to detect whether the subject has symptoms of coughing or sneezing. The Republic of China No. 363404 discloses the use of heart rate variability analysis ECG converter (with electrode pad) to measure the potential signal emitted by the patient during cardiac contraction, and then calculate by Fourier Transform and spectrum analysis. Heart rhythm variability, however, the object of the invention is to provide a novel heart rate variability analysis ECG converter and is characterized by a novel soft and hard body design and instrument system. The Republic of China No. 176,323 patent discloses the use of a non-invasive autonomic nervous system monitoring instrument system to measure the autonomic nervous system side effects caused by a patient taking medication and to monitor the degree of aging or treatment of the human body. None of the foregoing prior art discloses a non-invasive new piezoelectric sensor according to the present invention for accurately measuring an instrumental system of a wrist-arc waveform. The prior art does not disclose or suggest the use of the non-invasive novel piezoelectric sensor of the present invention as a measure of heart rate variability, measuring autonomic nerve function 'personal identification' respiratory waveform and cough measurement, home isolation, and The purpose of hospital isolation. [Summary of the Invention] 8 10 1323652 Measuring method for measuring the brachial artery waveform of the wrist. Another object of the present invention is to utilize this non-invasive technique to measure the average glory in blood pressure, which can be accurately: :: the dual-use blood pressure waveform-time map integral and the conventional electronic sphygmomanometer And diastolic blood pressure ' can be combined to calculate the average blood pressure. Ben: Ming's other purpose is to use this non-invasive, low-operating, high-accuracy wrist around the arterial waveform measuring instrument ., first to monitor the heart of the human body, the law of variability and autonomic nerve function . One of the purposes is to use this non-invasive brachial artery wave 1 to measure the instrument system as an application for personal identification. Another purpose of the wave type ί:: is to use this technique of non-invasive radial artery number to achieve physiological parameters for monitoring respiratory frequency and wave pattern. Another object of the invention is to develop a non-invasive type without relying on Controlled contact, can perform hospital isolation and monitoring of infectious diseases. Another purpose is to use this non-invasive radial artery system to achieve the goal of monitoring cough or sneezing. Another purpose of Ming is to develop - a non-invasive instrument system suitable for the control of the population. In order to achieve the technical means for achieving the aforementioned objects of the present invention, the embodiments are enumerated and described in conjunction with the drawings. [Embodiment] 1323652 The present invention is a non-invasive method for measuring the brachial artery waveform of a wrist, as shown in Fig. 1, which includes: <a) a piezoelectric sensor for measuring the radial artery of the wrist, It can continuously record and generate electric waves representing blood waves; (b) a wristband 2 containing an air bag, which can be attached to the wrist and pressed to the piezoelectric sensor 1 described above; (c) contains The pump 3 can be inflated and deflated, the bleed valve 4 and the air duct 5, etc.; (d) The circuit module 6 includes a central calculator, a memory, and a barometer connected to the air bag air pipe 7; (e) The operating software 8 contained in the circuit module, which can control the air pressure of the air bag, find the optimum test air pressure, measure the radial artery wave shape under the optimum test pressure, and apply the electric wave from the piezoelectric sensor Filtering, amplifying, and analyzing; (f) Power source 91, and (g) having an externally-excited device 9 that includes components (c) through (f) therein. According to the present invention, the piezoelectric sensor 1 can be, but is not limited to, the singularity of the lead zirconate titanate (PZT) piezoelectric sheet or the polymerized polyvinylidene fluoride (PVDF) housing sheet or the stress type (Strain). Gauge) Piezoelectric element, or semiconductor type (Semi-Conductor), piezoelectric element, etc.; the sensor 1 can be independent of the wristband or other hardware, but transmits the electric wave signal to the circuit module 6 through the connector. When testing, first fix the sensor 1 with a tape or elastic body, such as an elastic band or a rubber band, etc., above the radial artery of the wrist (as shown in Figure 2), and then bring the wristband with the main unit. Put on the wrist, and the air bag inside the wristband just presses the sensor. When the air bag is pressurized by the pump, the air bag applies pressure to the sensor, and the sensor applies pressure to the brachial artery, which causes the pulse signal of the sensor to be enhanced (refer to Figures 3a and 3b, 3c). One of the technical points of the present invention is to gradually increase the pressure of the air bag from zero to a certain pressure by using a pump (for example, 2 〇〇 mmHg, Fig. 3a), during which the blood pressure pulse wave of the sensor is recorded (the first) 3 b Figure) 'And calculate the main peak height of each pulse (Primary Peak Height, Figure 3 c). In general, the main wave height is first changed from small to large during the inflation period, and then becomes larger and larger. When the main wave height shows a maximum value (generally between 70-150 mmHg 'Fig. 3b), the airbag pressure at that time According to the invention, it is defined as an Optimal Testing Air Pressure. In this state, the sensor's blood pressure waveform signal is the strongest, that is, the signal-to-noise ratio is the highest. When the air bag pressure is lower than this value, the pulse signal is weak due to poor pressure transmission between the piezoelectric sensor and the radial artery; when the air bag pressure is higher than this value, the wrist band, the air bag, and the sensor Excessive pressure on the brachial artery, reducing arterial flow, also caused the pulse signal to weaken and deform. Another important step in the implementation of the present invention is that, at the beginning of measuring the brachial artery waveform, the optimum test pressure is measured by the above aeration step, and then the air bag is pressurized to the pressure value (or its vicinity) before proceeding. Blood pressure waveform monitoring. If the above aeration step is changed to a first 13 1323652 constant pressure value (for example, 200 mmHg), it is low. During this deflation period, find the optimum test dust as above. The shape and size of the above-mentioned repeated electric sensor are beneficial to the present invention and are implemented. According to the invention, the sensing body of the piezoelectric inductor can be a round shape, and the square shape is a thin sheet of other geometric shapes. The thickness of the pot can be from (M mm to 5 嶋, etc., and the diameter or side length can be from

1 〇〇 mm and other ranges. The preferred state of the piezoelectric sensor is a circular sheet whose straight handle is 2~5. _, the thickness is 〇" to 3 _, and the electric wave signal is transmitted to the circuit module through two positive and negative wires, and the electric power is ^ (Strain Gauge Piezoelectric Element or Semi-Conductor Piezoelectric Element requires external power supply, but PVDF chip does not require power). The battery or power supply of the electric switch group is transmitted through the wire. supply. ^ When testing, first use the finger to find the radial artery position, and then

Then gradually reduce the air bag pressure drop principle and steps, and the piezoelectric sensor can be fixed above it. According to the second embodiment of the present invention, the other preferred state of the piezoelectric sensor 1 is a rectangular sheet, the degree (in the direction of the hand) is 1 to 30, and the width (in the direction of the hand width) is ':5. ~60mm, other links or power supply characteristics are no different from the above. When testing, 'Because the sensor coverage is large enough, it is not necessary to find the exact surrounding artery position first'. As long as the sensor is fixed at the approximate position of the wrist rib artery, the test can be performed. According to the fifth figure of the present invention, Another preferred state of the dust electric sensor is that the rectangular sheet is placed in the wristband 2, and the face of the sheet is in contact with the five layers of cloth in the wristband. When measuring the 3 coats and the other side is worn with the wristband outside the main unit 9, simply press the wristband 2 and its attached instrument to the top of the wrist to test. According to the invention, a plurality of (at least two) piezoelectric electrodes are shown, the piezoelectric sensor 1 can be assembled, and the wristband 2: the member 11 is composed of a piezoelectric induction mold, wherein each component It is a rectangle (or h ^ bottom - flexible circuit board (_ printed eireuit „ step is to arrange a plurality of piezoelectric elements u according to the width of the hand! The mouth is on the flexible circuit board, there is - tiny between the components and the components Void ((U~lmm)' to avoid adjacent radio wave interference. In addition, in the circuit module of the present invention, a multi-signal scanner (Muh Plexer) and related software are installed. The above flexible circuit board will come from each sensing element. The radio signal is transmitted to the multi-signal scanner by a wire or a connector, which is then connected to the signal filtering and amplifying circuit. When the blood pressure pulse wave is measured, the multi-signal scanner sequentially picks up the pressure on the sensor module. The electric wave signal of the electrical component 'and compares and selects the piezoelectric component with the strongest electric wave signal. Compared with other components, the component must be positioned just above or near the radial artery, so the signal obtained is the strongest. According to the present invention, The component of the strongest signal is selected as the measurement component, and the signals of other components are no longer used. As for the other measurement steps (such as the optimum measurement pressure, etc.), the other preferred states are the same. The number of the above multiple components is at least Two, and three to five are 15 1323652 should be 'covering 10~25mm hand width 1f 1 . 粑 为 軚 軚 軚 軚 軚 軚 軚 軚 軚 軚 軚 軚 軚 軚 軚 軚 軚 軚 軚 軚 軚 軚 压电 压电 压电 压电 压电 压电 压电 压电 压电Due to the use of softness, the board as the base can be pressed closer to the wrist surface when tested, and the sensing range is large, which can be suitable for various hand sizes. The piezoelectric sensors of the above three preferred states have the advantage of brewing wave detection. The wide range of measurement can save the steps of finding the position of the finger and adapt to different hand sizes. In addition, the general public can measure it by itself, and it is not required to be operated by a trained physician or nursing staff. According to the present invention, The wristband can be a fabric wristband for the wrist-type electronic sphygmomanometer, which is equipped with an air bag. The size of the airbag is determined according to the general wrist blood pressure measurement (the width along the hand body is about 60). Between ~90mm, the circumference of the hand width is about 150mm between the two. The plastic (or rubber) airtight air bag usually has two air nozzles, one of which is connected to the barometer of the circuit module. The other is connected to the air pipe leading to the pump and the venting valve. When the pump receives the program software command of the invention, the vent valve is temporarily closed, the pressure of the bag is increased, and the value is monitored by the barometer; When the venting valve receives the command to start deflation, the venting valve is opened, and the air pressure of the air bag is lowered. For the convenience of the belt, a U-shaped or sturdy plastic piece is usually installed in the wristband, and the opening size of the plastic piece and the thickness of the wrist and The width is equivalent, and the wrist strap and the upper host are conveniently attached to the wrist. The plastic sheet further comprises a protruding buckle, which is exposed outside the wristband fabric, and functions to be combined with the outer casing of the host structure of the invention to fix the main body to the wrist. Above the wristband. According to the preferred state (3) 3652 of the above-mentioned 4th and 5th drawings of the present invention, a pocket can be added to the air bag, and the piezoelectric sensing element can be installed therein, and the air bag can be accurately inflated when the air bag is inflated. The pressure is applied to the piezoelectric sensor; similarly, the pocket of the piezoelectric sensor can be fixed at other positions within the wristband, for example, between the wristband fabric and the airbag for pressure. According to the present invention, the pump is similar to the air pump used in a general electronic sphygmomanometer, which receives a DC power source to push the blade and rotates to inhale. According to the present invention, the deflation valve may be a 〇n-〇ff solenoid valve switch similar to that used in general electronic sphygmomanometers, which accepts a programmed command to open or close the gas valve; and the vent valve may be analogous (Anal〇g) Solenoid valve switch, the size of the valve opening is determined by the voltage or current value. In this category, the valve can regulate the speed of the milking machine compared to the Ο η - 〇 ff switch (only fully open or fully closed). According to the invention, the substrate of the circuit module can be a printed circuit board (Printed Circuit B〇ard), which is embedded with a central calculator (cpu) memory (such as Flash or RAM, etc.), barometer, signal Filter components 'signal amplification components, buzzers, real-time clocks, and other electronic components. To facilitate the display of test procedures and results, the circuit module can contain a liquid crystal (lcd) or light emitting diode (LED) display. In addition, the circuit module can be retrofitted with a multi-signal scanner (Multi_piexer) to meet the circuit requirements of the preferred state of Figure 6 above. According to the invention, the circuit module carries an operating software, and the software program can drive the relevant hardware according to the operation flow chart shown in FIG. 7 (such as pump, gas valve, central meter 17 1323652 liquid crystal display, pressure Electric sensors, etc.) to achieve the following goals:

(1) Control the air pressure of the air bag; T (2) Find the optimum test pressure; (3) Measure the radial artery waveform at the optimum test pressure; (4) Filter and amplify the measured wave signal; (5) Analyze and calculate the measured wave signal. According to the present invention, the power source can be provided by a general dry battery (disposable) lithium battery (reusable for recharging), a nickel hydrogen battery (reusable for recharging) or other types of batteries. Further, the power source required by the present invention can be supplied by a general AC power source (e.g., 110V or 22 〇V, etc.). If a parent flow source is used, an AC to DC transformer (Transf0rmer) can be added to the circuit module of the present invention to provide the power required to receive only DC circuit components. According to the present invention, by using the aforementioned non-invasive pulse wave accurate measurement technique, the physiological mean blood pressure in blood pressure can be measured according to the following steps: (Physiological Mean Blood Pressure): (4) According to the electronic sphygmomanometer (Oscillometric)

Method) measured systolic blood pressure (SBP) and diastolic blood pressure (DBP); (b) According to the invention: !: Measure a precise blood pressure waveform and plot it in the χ γ plane (Fig. 8) where the γ axis is relative The voltage value V, the X axis is the real time t; (c) The average value of the relative voltage of the blood pressure waveform of (b) is calculated by the following formula. V(mean)= V—t integral value/(t2 — tl)......(1) 1323652 where V(mean) is the relative electric mean value, V_t integral value is v _t wave type The integral value of the graph in the range of tl (waveform start point) to t2 (waveform end point), t2-11 is the time interval of a single wave pattern, and (d) the physiological mean blood pressure is calculated according to the following formula: PMBP=V (mean)*(SBP-DBP)/(VS-VD).......(7) where PMBP is the physiological mean blood pressure, V(mean) is the relative voltage average, SBP is the contraction dust, and DBP is the diastolic pressure. VS is the maximum value (peak) of the blood pressure waveform, and VD is the minimum value (valley) of the blood pressure waveform. In order to obtain a more representative and accurate physiological mean blood pressure, one of the preferred states of the present invention is to extract more than one blood pressure waveform, calculate the physiological mean blood pressure PMBP of each blood pressure waveform, and then perform the plurality of PMBPs. Take the average value according to the following formula: PMBP(mean)= SUM(PMBP)/N.......--(3) where PMBP(mean) is the average value of the physiological mean blood pressure PMBP, and SUM(PMBP) is The sum of N PMBPs, where N is the number of blood pressure waveforms. The above-mentioned conventional electronic blood pressure oscillation technique (Oscillometric

Method, see US patent 4,860,760), the general practice is as follows: (a) quickly increase the air pressure of the air bag to a certain value (such as 200mmHg); (b) record the blood pressure of the barometer in a gradually slow deflation Waveform, and calculate the Peak Height and make the wave height-time XY map; (c) Find the maximum value of the wave height during the deflation on the graph; 1323652 (d) Based on the maximum value of the wave height, follow the x-axis The direction of the air pressure rise finds the air pressure corresponding to 50% of the maximum wave height, which is the Systolic Pressure (SBP); (e) Based on the maximum value of the wave height, the direction of the pressure reduction of the x-axis is found to correspond to The pressure at 70% of the maximum wave height, which is Diastolic Pressure (DBP); (f) The measured systolic and diastolic pressure values are corrected according to the clinical calibration procedure to improve accuracy. The instrument system of the present invention has the wristband, the air bag, the barometer, the central calculator, the pump, the deflation valve, and the operating software required for the above steps, so that the systolic and diastolic pressures can be measured according to the above steps. According to the inductive waveform piezoelectric sensor of the present invention, the accurate blood pressure waveform is measured, and finally the medically important physiological mean blood pressure is calculated according to the above formulas (1) to (3). According to the present invention, the blood pressure pulse is measured by a non-invasive fraction, and the heart rate variability and autonomic nerve function can be measured according to the following steps: (a) during the test period (eg, 5 minutes or 24 hours) The continuous blood pressure waveform of the subject; (b) select one of the special reference points in the blood pressure waveform; the fixed point (such as the main peak apex) is the wave (c) calculate each waveform reference point plus & + ,,."5 The time interval of the next wave type reference point (such as the main peak-main peak spacing); (d) Calculate the time between the test period (e) and the time interval as the average of the fast pitch and Standard deviation; Lille conversion method (Fast Fourier 20 1323652

Transform) into a spectrum ' and calculate high frequency components (Higll)

Frequency Component, HF, 0.15-0.4 Hz), low frequency component (Low Frequency, LF, 0.04-0.15 Hz), very low frequency component (Very Low Frequency, VLF, 0.0-0.04 Hz), and total variability (Total Power); (f) Define the average time interval in (d) as the heartbeat period (Period), the reciprocal of which is defined as the heart rate (Heart Rate); and the standard deviation of the time interval in (4) (Standard Deviation) as the heart rate variability ( Heart Rate Variability (HRV); defines the heart rate variability in (f) and Total variability in (e) as an indicator representing the total activity of the autonomic nerve; calculating LF according to the parameters in (e) %( = LF/(LF + HF)*100o/〇) and HF%(=HF/(LF + HF)*100%), and define LF% as an indicator of sympathetic activity, and HF% as a representative of parasympathetic nerve The indicator of activity, another definition of LF/HF is an indicator of sympathetic-parasympathetic balance. For the above analysis of heart rate variability (including Time Domain and Frequency Domain), the definition of its parameters, and its relationship with autonomic nervous function, please refer to "Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement » physiological interpretation, and clinical use. Circulation. 1996; 93: 1043-1065." 1323652 Generally normal human hand artery waveform can be divided It is a 1-wave type (Fig. 9a), a 2-wave type (Fig. 9b), and a 3-wave type (Fig. 9c). According to the present invention, as shown in Figures 9a to 9c, and Table 1, by using the aforementioned non-invasive precise blood pressure waveform measurement technique, the identity of the subject can be identified by the following steps: (a) taking a regular period (e.g. Continuous blood pressure waveform of the subject from 50 seconds to 丨 minutes; (b) Find the starting point (ie, the coincidence) of each blood pressure waveform as shown in Figures 9a to 9c, and the end point (ie, the next waveform) (starting point), and each peak point and trough point; (c) Calculate the number of peaks of each blood pressure waveform as shown in Figures 9a to 9c, time 'willing force, bevel angle, area, and its normalization (N〇rmalized) And other characteristic parameter values (refer to Table 丨); (d) Calculate the average value of these parameter values during the test period and define them as the subject's blood pressure waveform characteristic baseline (Characteristic Baseline) (4) If the next identity If the blood sputum type of the unknown subject has a considerable degree of similarity (^imilarity) with the characteristic reference line of (d), it is determined that the subject and the subjects of (4) to (4) above are The same person, otherwise different people; (0 if there are - group of people (such as two or more people) first measured blood The wave-shaped feature baseline, if one of the people is tested in an unidentified manner in the future, the individual data of the group can be compared according to the blood-wave characteristic parameter value of the subject, and the highest similarity is selected. 8 22 1323652 It is judged that the subject is the known identity; the so-called "degree of similarity" can be specified according to the experimental and identification requirements. One of the more stable states of the present invention is to characterize the blood pressure waveform. All parameter values are equal weighting, and the similarity of each value is defined as the positive and negative percentage value of the feature baseline (eg ±20%), and when more than one of these parameters is predetermined If the proportion of the number (such as 80%) satisfies the similarity of the parameters, then the total similarity criterion is determined. Therefore, the blood pressure waveform data of the two groups are determined to be from the same person, otherwise they are different people. The similarity of the above parameters can be determined according to the needs. Is ±10% or less of the characteristic baseline to increase the identity discrimination, or to be ±30% or higher, to reduce the identity rigor; likewise, to satisfy the similarity The number ratio can also be set at 90% or higher to increase the discriminating degree of discrimination, or set at 7% or lower to reduce the stringency. One of the other preferred states of the invention is that the 9a The number of peaks in the parameters of the 9c graph (generally 1〇 to 3〇) and the time after normalization (N〇n^alized), the values of the characteristic parameters of pressure, bevel, and area are defined as the focus of similarity. Parameters, while other 'pressure' angles without the standard 2, and area parameters are non-key parameters. When the parameter similarity is satisfied (for example, within ±2〇% of the characteristic baseline) = non-key parameters exceed the prior When the predetermined number of proportions (such as 80%), the blood pressure waveform data of the two groups are judged to be from the same person. When the non-key parameter satisfying the parameter similarity is lower than the predetermined number of proportions, but the key parameter satisfying the parameter phase 23 1323652 is more than the predetermined number of proportions (if the time is still determined, the two sets of blood pressure waveform data are from the same person, otherwise For different people. As mentioned above, the arterial blood pressure waveform sometimes changes slightly due to emotional and physiological factors (such as nervousness, anger or rapid heartbeat when fever, elevated blood pressure), but the inventors found that after normalization (Normalized The time, pressure, bevel, and area characteristic parameters are quite stable and become a personal feature. At the same time, the accuracy of the identification can be improved by comparing the characteristic parameters of the unnormalized and standardized (N〇rmaiizecj). The above-mentioned Normaiization step can follow the normalized mathematical or statistical standardization steps, and the goal is to convert a parameter value having a physical unit into a parameter value without a unit. For example, Figures 8a to 8c. And the table shows that one of the preferred states of the normalization step of the present invention divides each time parameter value by blood. The period of the wave pattern (Pedod; wave-wave spacing); the value of each pressure parameter divided by the peak height of the blood pressure waveform (see definition in Figure 3c); the denominator of each oblique parameter value divided by the peak of the blood pressure waveform High (see the definition of Figure ))' and f molecules divided by the period of the blood pressure waveform (Period; that is, the wave-wave gate distance), the value of each area parameter divided by the total area of the blood pressure waveform. Because of the natural aging of the human body and For acute and chronic diseases, each person's blood pressure waveform will gradually change with time. Therefore, the above-mentioned blood pressure waveform characteristic baseline should be periodically updated (10), such as every year or two, to maintain the quasi-rotation of identification. 24 1323652 Table 1 Blood pressure waveform characteristics Parameter value definition parameters / Parameter definition 1 - Wave type (Fig. 8a) 2-wave type (Fig. 8b) 3-wave type (Fig. 8c) Number of peaks 1 2 3 Main peak point BBB Main wave valley Point A, CA, EA, G secondary peak no DD, F secondary valley no CC, E Tl=ab Tl=ab Tl=ab T2=ac T2=bc T2=bc T3=cd T3=cd Time parameter T4= De T4=de T5=ef T6=fg NTl=ab/ac NTl=ab/ae NTl=ab/ag NT2=bc/ae NT2=bc/ag Normalized NT3=cd/ae NT3=cd/ag Time Parameter NT4= De/ae NT4=de/ag NT5=ef/ag NT6-fg/ag Pl=Aa Pl=Aa Pl=Aa P2=Bb P2=Bb P2=Bb P3=Cc P3=Cc P3=Cc Pressure parameter P4=Dd P4=Dd P5=Ee P6=Ff 25 1323652 Normalized pressure parameter NPl=Aa/Bb NP2=Cc/BB NPl=Aa/Bb NP2=Cc/BB NP3=Dd/Bb NPl=Aa/Bb NP2=Cc/BB NP3 =Dd/Bb NP4=Ee/Bb NP5=Ff/Bb Angle parameter Dl=(Bb-Aa)/ab D2=(Bb-Cc)/bc D3=D1+D2 Dl=(Bb-Aa)/ab D2 =(Bb~Cc)/bc D3=(Dd-Cc)/cd D4=(Dd~Ee)/de D5=D1+D2 D6=D3+D4 Dl=(Bb-Aa)/ab D2=(Bb- Cc)/bc D3=( Cc-Dd)/cd D4=(Dd~Ee)/de D5=(Ff-Ee)/ef D6=(Ff-Aa)/fg D7=D1+D2 D8=D3+D4 D9=D5+D6 standardized oblique angle NDl=((Bb-Aa)/Bb) /(ab/ac) ND2=((Bb~Cc)/Bb) /(bc/ac) ND3=ND1+ND2 NDl=((Bb-Aa)/Bb) /(ab/ae) ND2=((Bb-Cc)/Bb) /(bc/ae) ND3=((Dd-Cc)/Bb) /(cd/ae) ND4=((Dd-Ee)/Bb /(de/ae) ND5 = ND1+ND2 ND6 = ND3+ND4 ND1= ((Bb-Aa)/Bb) /(ab/ag) ND2=((Bb-Cc)/Bb) /(bc/ag ND3=((Cc-Dd)/Bb) /(cd/ag) ND4=((Dd~Ee) /Bb) /(de/ag) ND5=((Ef-Ee)/Bb) /(ef/ Ag) ND6=((Ef-Aa)/Bb) /(fg/ag) ND7 = ND1+ND2 ND8 = MD3+ND4 ND9 = MD5+ND6 1323652 Area parameter A1 = AabB A2 =BbcC A3 = A1+A2 A1 = AabB A2 =BbcC A3 = CcdD A4 = DdeF A5 = A1+A2 A6 = A3+A4 A7 = A5+A6 A1 = AabB A2 =BbcC A3 = CcdD A4 = DdeF A5 = EefF A6 = FfgG A7 = A1+A2 A8 = A3+A4 A8 = A5+A6 A9 = A7+A8+A9 Normalized area parameter ΝΑΙ = Α1/Α3 NA2 = A2/A3 NA1 = A1/A7 NA2 = A2/A7 NA3 = A3/A7 NA4 = A4/A7 NA5 = A5/A7 NA6 = A6/A7 NA1 = A1/A10 NA2 = A2/A10 NA3 = A3/A10 NA4 = A4/A10 NA5 = A5/A10 NA6 = A6/A10 NA7 = NA1+NA2 NA8 = NA3+NA4 NA9 = NA5+NA6 Note: (1) Lowercase a, b, c, d, e, f, g, etc. are time points in seconds. (2) Uppercase A, B, C, D, E, F, G, etc. are points on the blood pressure waveform curve, and the coordinate unit is (pressure, second) or (voltage, second). (3) The area parameter (such as AabB) is the integration of the four corner points and the curve (which can also be simplified as 27 trapezoidal areas formed by four corner points). According to the present invention, the first diagram, the second diagram, and the second diagram, J uses a non-invasive accurate blood pressure waveform measurement technique to measure the respiratory waveform and frequency according to the following steps: (a During the trial period (eg, ~ 〇 〇 minutes), continuously take the blood pressure waveform of the subject and make X_Y® (Fig. 1), where X is time and γ is voltage or pressure; (b) Find the X value (ie time value) of the main peak point of each waveform and the γ value (ie voltage or pressure value) (see Figure 1〇b); ) The data of the main peak point of the word (b) is made continuous XY map (Fig. 11), which is the respiratory waveform of the subject; (4) The number of waveforms (such as eight) in each periodic (such as one minute) is the respiratory rate or the number of breaths (such as per On the basis of eight times a minute, the calculation of all the calculations of the m-wave peaks is changed to the main trough (that is, the starting point of each wave type, which is also the most basic (4) basis, and also depends on the step = Respiratory waveform and frequency (or number of breaths). In addition, according to Figure 10b and D, the main peak of the main peak of the New Zealand map is not 'if the subject will be poured - Ju (refer to Figure 10b) to calculate, and as a heart rate between Γ) as w, the corresponding time Tian Cheng X value, and make a continuous X τ diagram) is the subject's respiratory waveform: the same figure 2. In the figure (in Figure 12, for each periodic (such as - minutes) = ground, calculate the number of waveforms of this respiratory waveform (such as eight), 28 1323652 is the frequency of suction or sucking (such as each According to the figure of the present invention, the above-mentioned non-invasive blood pressure wave type measurement technique can be used to detect the symptoms of the blood pressure waveform of the subject: ^ or spray (a) continuous #| (9) Calculate the value of the blood clot type of the subject in the initial period (such as one minute) (ie, the time interval of the main peak _ main wave bee, the main peak ί = value, and the pressure value of the main valley) The average value and the standard, the average value is defined as the baseline of the three-parameter value; (4) The three parameter values of the blood pressure waveform are monitored at any time during the test, and if a wide (including above) deviates from the baseline to the standard deviation 2 = number (for example, above 30 degrees, the waveform is called a suspicious irregular data point; (4) right this suspicious irregular data point The aid-fixed frequency (for example, once every four wave types) is ignored; (4) If the suspected irregular data point occurs randomly (without rate), then the data point is defined as coughing or sneezing. (f) The frequency of coughing or sneezing (such as three times per minute) can be obtained by regularly counting the sneeze or sneezing point of (4). The above-mentioned predetermined standard deviation multiple can be verified by human experiments. For example, lighter For a shallower cough, the blood money type deviates from the average value to a lower degree, because the standard deviation multiple of the pre-predicted can be reduced to 3 to 4 » and the heavier:早乂垔#And ice coughing or sneezing, then 4 to 0. And the above-mentioned - macro heart 砀 ' 可 frequency of suspicious irregular data points, often 29 1323652 疋 due to heart rate irregularities (Cardiac Arrhythmias), therefore should Excluded. The invention further provides a novel physiological signal monitoring instrument system for hospital isolation patients (as shown in FIG. 14), which comprises: (a) the non-invasive accurate blood pressure wave type measuring technology and instrument thereof according to the present invention. (b) conventional body temperature measurement technology 'and place the temperature sensor on the wrist of the (a); (c) I know the wireless signal transmission technology' and place a set of wireless transmission transceiver modules (a) in the host, the other group is placed in the bedside analyzer in the ward responsible for receiving the patient's physiological signals; (d) measuring the heartbeat, blood pressure (systolic blood pressure) of the isolated patient using the instrument system (a) above , diastolic blood pressure, physiological mean blood pressure), respiratory waveform and frequency, and determine whether the patient has heart palpitations, shortness of breath, coughing or sneezing; • (e) measuring the patient with the temperature sensor of (b) above The body temperature of the wrist, and - determine whether the patient has a fever; (f) the physiological signals of (4) and (4) are transmitted by the host of (4) to the bedside analyzer of (c); (ω) bedside analyzer Transmitting the patient's physiological signals and their analysis results through a regional network (Local Area Network, Lαν) or Internet (Internet) out of the ward. The above-mentioned conventional body temperature measurement technology can be used to use a small thermocouple, a resistive electronic component, or a Vm λ ι, ι.»,. . All three 1323652 are thermal components that convert body temperature into voltage or current signals. In order to improve the accuracy of the body temperature measurement and reduce the time required to reach the temperature balance, in addition to the aforementioned thermal sensing element, a small piece of metal can be added to the wristband, the outer surface of the metal piece is exposed outside the wristband fabric, when worn Direct contact with the wrist skin and responsible for heat conduction. The metal sheet is additionally connected to the thermal sensing element in the wristband, and the thermal sensing element is coupled to the circuit module of the present invention to form a complete body temperature measuring system. The above wireless transmission technology can use a commercially available RF (Radic) Frequency wireless module, and the frequency range can be in the commonly used Band (ie [industry, science, medical] shared frequency band), and the most commonly used communication protocol is Bluetooth. (Blue Tooth, 2.4 GHz) Wi-Fi (including IEEE 802.11b, 802.1 1a 'and 802.1 ig, 2·4 to 5 6 GHz), and low frequency ISM (433 to 915 MHz). In addition, the US Food and Drug Administration (FDA) has also established a WMTS channel (608~1429 MHz) for medical devices. Usually the RF wireless module operates in a pair of two-way inter-transmission mode.

Taking the above-mentioned application of the present invention as an example, one of the wireless transceiver modules is placed in the wrist type host of the present invention, and the other is placed on the bedside analyzer in the isolation ward. The bedside analyzer can be a desktop or portable computer, or other instrumentation system with computing, storage, display, and transmission functions, and the wireless transceiver module and the bedside analysis state can pass through a standard interface (eg, rS_232(c〇m Port), USB, IEEE Ϊ 323652 1 3 9 4 4 ) Link. If the heartbeat of the aforementioned patient exceeds the normal heart rate as defined by the general medical definition (e.g., up to 100 times per minute), the patient is judged to have palpitations; the above judgment of coughing or sneezing has been explained and will not be repeated. In addition, an upper respiratory frequency limit (such as 20 times per minute) can be defined. When the respiratory rate of the subject exceeds the upper limit, it is determined to be shortness of breath; in addition, 'other medical standard can be used when the patient's body temperature exceeds 38 degrees When c, it is judged to be a fever. When the patient's physiological signal is transmitted to the bedside analyzer, it can be stored, analyzed, and displayed on it, and then transmitted through the local area network (LAN) or the Internet (in the p-unit). Lnternet) out of the ward (for example, to a centralized nursing station or hospital patient data server, etc.). The present invention further provides an instrument system for monitoring a home-segregating population (as shown in FIG. 15), which comprises: () introducing the non-invasive precision reading pressure waveform measurement technology of the present invention and a system instrument system thereof; (b) Using the instrument system of (a) to measure the heartbeat of the home, the blood pressure (systolic pressure 'diastolic pressure' average pressure), blood pressure waveform, respiratory waveform and frequency and other physiological signals' and judge whether the public Have a heartbeing 'severe blood pressure changes, shortness of breath, coughing or sneezing; (c) measuring the body temperature of the person using a known body temperature measurement technique, and judging whether there is a fever symptom; 32 1323652 (d) by knowing wireless Transmission technology will (a) ~ (c) a to the signal receiving analyzer placed in the home; stomach sfl periodic transmission (4) = receiving analyzer to store physiological information, analysis and regular Internet (Int (10) et) transmission Or telephone data (: dem hidden health institutions (such as Wei, the Department of Health, ^ hospital (f) health agencies regularly collect, sort out 'ϋ statistics no disease' and the number of isolated people who have been restored. χ To prevent irregularities, health organ At any time, use the network = road or telephone data machine to issue test instructions to the bedside analyzer, and the bedside _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ The notification sound of the monitoring host (through its 含 态 ) ) ) ) ) ) ) 便 便 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理 生理Within a minute, no physiological signals were received, and the people should be judged to go out in violation of the regulations, and further control measures were taken. If the segregated people went out in violation of the rules, they were judged by others at home to identify the identity authentication technology provided by the health agency. It is possible to judge the data of the phase-to-person and take the necessary control measures. The signal receiving analyzer can be a desktop or laptop = 'or portable digital assistant (PDA)' or have transmission, storage, analysis : and other instruments that show the power, the above-mentioned non-onset, has been onset, the definition of recovery, can be changed by the health authority according to blood pressure, call 33, frequency, cough and sneezing, and body temperature, etc. The specifications of the physiological parameters are controlled. The techniques of body temperature, blood pressure, wireless transmission and network transmission are described in detail above and will not be described again. The following η grievances are only used to illustrate the invention, not limited The invention is composed of the following components (as shown in Fig. 16 and the components are labeled): (a) one consisting of a strainer (Strain Gauge). Piezoelectric sensor la ', the main off-size is 5mm round sheet (3mm thick), including signal filtering, amplification, correction, temperature compensation and other circuits. In addition to the round up > / sensor body, there is another wire connection A circuit module to the wrist physiological monitor host (to be described). The wire serves to supply the piezoelectric sensor power and transmit the piezoelectric signal to the circuit module. (b) Wrist physiological monitor main unit 2a, which contains a pumping pump, a venting valve, a standard 2A dry battery (two), an RS232 port, a barometer, and a central processing unit, memory, And circuit processing (signaling 'amplification' correction) circuit module. The main body further includes an outer cover and a lower cover housing. The outer casing includes a buckle and a small opening, which can be fixed on the wrist wristband (to be described), and has a button for operating the instrument. (c) Wrist strap 3a, which contains an air bag and a us plastic sheet. The plastic sheet has a buckle and a small hole, which can be combined with the 34 1323652 lower cover of the wrist type main body. The length of this wristband is longer than the circumference of the wrist, so the remaining length can be reversed after a week around the wrist, and the devil is fixed. The procedure of the instrument is described as follows: (d) The finger is placed on the wrist of a healthy volunteer (both left and right hands) and the exact position of the radial artery is measured. (e) Fix the circular piezoelectric actuator body of (a) above the artery with a tape. (f) Attach the wrist strap of (b) to the wrist of the subject with the wrist strap of (c). (g) Press the “Start” button of the instrument main unit (b) to start the test. At this time, the control software gives the command to the pumping pump to start pumping (the gas valve is closed). When the air bag is pressurized to 200 mmHg. (Barometer value) When the 'manipulation software release command' is given to the bleed valve for slow deflation. At the same time, the 'control software and circuit module reads and stores the pressure value of the barometer and the pulse signal of the piezoelectric sensor at a speed of 5 每秒 per second, and controls the software and calculates the deflation period (2 〇〇 drop) The wave height (ie, peak-valley) of each pulse wave up to 30 mmHg (about 20 seconds), and determines the gas pressure value at which the maximum wave height occurs. This gas pressure value (93 mmHg) is the optimum test gas pressure. (h) Control the software and then give the command to the pumping pump to raise the air pressure from 30 mmHg to the optimum test pressure (93 mmHg). After that, the control software and circuit module also read the voltage at 5 每秒 per second. The pulse signal of the electric sensor is sampled for 5 seconds, and the material and corresponding time value (taken from Real-Time Clock) are stored in the memory of the circuit module. (1) Open a personal computer and connect it to the RS-232 port of the wrist host with its RS-232 (COM Port) connection. The personal computer's software release command is given to the circuit module of the wrist host and its operating software' to start data download. (1) The PC control program plots the downloaded data in X_Y mode, where the X-axis is time (in seconds) and the γ-axis is the piezoelectric sensor's blood pressure value (in mmHg). The result is shown in Figure 17. The brachial artery turbidity and smear method is based on the instrumental soft and hard body used in this example. The operation part and the healthy volunteers are similar examples, but the piezoelectric sensor is an example. 55-mm circular body is changed to a 5_ claw length made by ceramic ρζτ (/ mouth length direction) X 2〇_mm width (along hand width) χ 2_mm thick piezoelectric element, in addition, wrist The main unit adds an LCD display. According to the procedure of Example 1, the maximum wave height during the deflation period (the current gas pressure value is 93 mmHg) is obtained, that is, an example! Steps (after the illusion, continue with the following steps: (a) The steering analysis software of the wrist host is based on the maximum wave height occurrence point. The γ is opposite to the pressure relief direction (ie, the direction of the air pressure rise). The wave height is exactly 50 of the maximum wave height. The blood pressure waveform of %, the pressure value (138 mmHg) at the time of the blood pressure waveform is the systolic blood pressure; the manipulation analysis 36 software and the search for the wave height in the direction of the shallow gas (that is, the direction of the gas drop) is exactly 70% of the maximum wave height. The blood pressure wave type, the pressure value of the blood pressure wave type (83 mmHg) is the tension. (7) According to the relevant human experiment, (4) the harvest (4) needs to be corrected downward 25 mmHg 'diastolic pressure needs to be corrected downward 1 〇mmHg, can be the correct systolic pressure (] 13 mmHg) and diastolic blood pressure (73 mmHg). (4) According to the formula (1)~(7) in the 'Detailed Description of the Invention', calculate the test within 5 seconds. (average mean physiological blood pressure " ( 86 mmHg). (4) The wrist-type main unit displays the average value of the physiological mean blood pressure (86 side) on the LCD display. (e) According to relevant human experiments, the health volunteer is Invasive The systolic blood pressure, diastolic blood pressure, and physiological mean blood pressure measured by the hand artery were 11〇, 68, and 85 mmHg, respectively. The results showed a non-standard invasive cannula artery test method and the non-invasive radial artery wave of the present invention. The systolic blood pressure, diastolic blood pressure, and physiological mean blood pressure measured by the type of technique are highly similar. UP : Non-invasive pulse type measurement method ^ Function Jing Qi Xi Ying, instrument hardware and examples used in this example 2 Similarly, there were two healthy volunteers participating. In addition, the piezoelectric sensor was changed from the PZT piezoelectric material of Example 2 to the polymer pvDF material, and its shape 37 J J was 5 mm long (along the length of the hand) X 20-mm wide (along the hand width =) X 〇.5mm thick. In addition, the piezoelectric sensor is pre-installed in the wrist ▼ between the airbag and the outer wristband of the wristband, and its tail connector (Tail Connector, consisting of a flexible circuit board) through the inside of the wristband and its small opening, the lower cover of the wrist-type mainframe, and finally connected to the circuit module in the mainframe. The signal processing circuit of the circuit module and the LCD display and the example 2 No problem, when you wear it, just fix the wrist host with a wrist strap. It can be used on the wrist. After the operation, follow the steps in Example 1 to obtain the continuous blood pressure waveform type. Then perform the following steps: (a) Continuously extract the blood pressure waveform of the subject for 5 minutes. The control software of the wrist host is analyzed. The peak-to-peak time interval of each blood pressure waveform during the test period is calculated. (b) According to the literature Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, , and clinical use. Circulation. 1996; 93: 1043-1065. The method described calculates the heart rate variability parameters of the subject's time domain (Time Domain), ie heartbeat cycle, heart rate, heart rate variability (HRV). (c) Calculate the heart rate variability parameter of the subject's frequency domain according to the above literature, ie total power (Total Power) 'high frequency component (HF), low frequency component (LF), and low frequency component / high frequency Component ratio.

38 ί. r\ 1 丨Elf ___ j 77 (d) According to the above literature, the total variability of heart rate variability and frequency range in the time range is defined as the index of autonomic nervous activity; the frequency component (HF) and high frequency components of the frequency range The percentage (HF/(CHF + ?)) x 100%) is defined as the indicator of parasympathetic activity; the low frequency component (LF) of the frequency range and the percentage of low frequency component X 100%) are defined as indicators of sympathetic activity; low frequency components/high The frequency component ratio (LF/HF) is defined as the sympathetic/parasympathetic balance indicator. (e) In addition, the subject also received a 5-minute standard electrocardiograph (ECG) test at the same time as the above-mentioned blood pressure waveform test (the connection method was a standard three-electrode method, LeadI, II, and claws, and was taken as Leadn's Bay). The material is calculated as the source), and the heart rate variability parameters of the time and frequency ranges are calculated according to the above documents. (0 test results are shown in Table 2. The results of two healthy volunteers (codes A, B) show that the standard electrocardiograph (ECG) test method and the original is not the same as the "inductive ridge wave type technology" The heart rate variability and autonomic nerve activity index results are highly similar. 39 1323652

^ Heart rate variability and autonomic nerve activity index test results • Γ _____ Subject code A test method hcg The invention ECG wood invention test posture reclining 't, W / 1 body still heartbeat cycle (S) . ^ 910 0.907 0.723 0.723 Heart rate (times/min) s66 66 83 83 Heart rate variability (HRV) (ms); ie standard deviation 45.1 46.0 57.1 55.4 Total variability - (Total Power) (ms*ms) 2037 2120 3265 3073 LF (ms*ms ) ___420 426 413 418 LF% 63 61 32 31 HF (ms*ms) 275 894 943 ' HF% 38 39 68 69 LF/HF ___1.67 1.55 0.46 0.44 Example 4: Identification with _^ Heating ^ The instrument H hardware is similar to the example 2, but the M inductor is composed of the following components: (a) a flexible circuit board, as the base and basic circuit of the piezoelectric inductor, the body size is 6mm long (along Hand length direction) x2〇mm width (along the hand width direction) X 0.5_ thick; the other end connector size 8 40 1323652 is 6mm X 50mm x 〇.5mm. (8) Three Taoman PZT plant electrical components 'each of which is long) χ 4 female (wide) xImm thick, and arranged along the width of the hand, on the flexible circuit board, components and components (refer to Figure 5). The piezoelectric sensor is pre-installed in the wristband with the same 'step 3'. In addition, the circuit is peaked at the signal (4), amplified, two, positive) circuit, and a multi-signal scan is added (Multi- The Plex is placed outside the signal processing circuit. When the control software of the second wrist and the second host drives the multi-signal scanner, the electric wave signals of the various components of the electric induction sensor are sequentially operated, and the blood pressure wave type of the components is high (: 2 - Step select the piezoelectric control software with the maximum wave height into the door center & as a blood pressure waveform data = its two components are no longer used. After that, the operation of the optimal pressure test step is shown as shown in example i. Under the optimum pressure measurement, a continuous blood pressure wave test was performed for ten seconds. Subjects A, B' and C each received the first test (Figs. 17, 18, 19), and one of the testers on the first day Unidentified and accept the second test: 20)); the blood pressure waveform and its parameter values of the test results are listed in Figure 17-20 and Table 3. From Figure 18, 20 艿 main, .al (10) and Table 3 can be found, The blood pressure wave (four) parameter values of the three remaining people are all different. Into a part of the unidentified person with a 2_ wave blood pressure waveform, apparently very different from the 3-wave blood pressure waveform of the two C (refer to the 19th, 2nd map and the skin type all 41 characteristic parameter values (Package ^ 1323652 peak number 'time, pressure 'bevel angle, area, and its normalized characteristic parameter value) are treated equally (q ^ weighting), and the similarity of each parameter value is defined as eight feature baseline Within ±20%, the unidentified subject 妓, 丨, a parameter value (93%) and the subject A satisfy the similarity, and: ^ 38 : ί, (61%) and the subject B satisfies similarity Sex, so there are 25 Ν疋 the unidentified subjects 匕 further design fits.) ... for the party tester 其 (the results and the experiment 8 42 Table 3 test subjects blood pressure wave characteristics parameter value testee / parameter ABC Unknown identity peak number 2 2 3 2 Main peak point BBBB Main wave valley point A, EA, EA, GA, E secondary peak point DDD, FD secondary valley point CCC, EC Tl=0.155 Tl=0.095 Tl=0.090 Tl=0.160 Time parameter T2=0.195 T2=0.230 T2=0.100 T2=0.165 T3=0.055 T3=0.060 T3=0.045 T3=0.055 (sec) T4=0.345 T4=0.360 T4=0.100 T5=0.085 T6=0.590 T4=0.385 NT1=0.21 ΝΤ1=0·15 NT1=0.09 NT1-0.21 Normalized NT2=0.26 NT2=0.35 NT2=0.10 NT2=0.22 NT3=0.07 NT3= 0.09 NT3=0.04 NT3=0.07 Time parameter NT4=0.46 NT4=0.55 NT4=0.10 NT5=0.08 NT6=0.58 NT4=0.50 Pl=34.1 Pl=37.5 Pl=25.7 Pl=34.2 Pressure parameter P2=37.3 P2=40.4 P2=29.6 P2=37.4 P3=35.1 P3=38.7 P3=28.4 P3=35.2 (mV) P4=35.2 P4=38.8 P4=28.5 P5=27.3 P6=27.8 P4=35.3 43 1323652

Normalized pressure parameters NP1=0.914 NP2=0.941 NP3=0.944 NP BU 0.928 NP2=0.958 NP3=0.960 NP1=0.869 NP2=0.959 NP3=0.963 NP4=0.938 NP5=0.940 NP1=0.914 NP2=0.942 NP3=0.945 Dl=20.65 Dl= 30.10 Dl:43.00 Dl=20.06 D2=11.28 D2=7.39 D2=12.00 D2=13.09 D3=1.82 D3=1.67 D3=2.44 D3=2.00 D4=3.19 D4=3.89 D4= 7.50 D4= 2.65 Oblique angle parameter D5=31.93 D5 =37.49 D5=0.82 D5=33.15 D6=5.01 D6=5.56 D6=3.68 D6=4.65 D7=55.00 D8=9.94 D9=4.50 ND 1=0.415 ND Bu0.484 ND1=1.469 ND1=0.411 ND2=0.227 ND2=0.119 ND2= 0.410 ND2=0.268 ND3=0.037 ND3=0.027 ND3=0.083 ND3=0.040 Normalized ND4= 0.064 ND4=0.063 ND4= 0.256 ND4= 0.054 々,队么么 each L ND5=0.642 ND5=0.603 ND5=0.028 ND5=0.679 Bevel Parameter ND6=0.101 ND6=0.090 ND6=0.126 ND6=0.094 ND7=1.879 ND8=0.339 ND9=0.154 Area parameter Al=5.53 Ab 3.70 A1 = 2.49 Al-5.72 A2= 7.06 A2=9.10 A2 = 2.90 A2= 5.99 A3 = 1.10 A3= 1.162 A3 = 1.28 A3= 1.94 A4= 11.95 A4= 13.72 A4 = 2.81 A4= 13.40 A5= 12.59 A5= 12.80 A5 = 2.36 A5= 11.71 A6= 13.0 5 A6= 14.88 A6= 15.76 A6= 15.34 44 1323652 A7= 25.64 Α7= 27.68 Α7 = 5.39 Α8 = 4.09 Α9 = 18.12 Α10=27.60 Α7= 27.05 Normalization ΝΑ 1=0.216 ΝΑ1=0.134 ΝΑ1=0·090 ΝΑ1=0.211 Area Parameter ΝΑ2=0.275 ΝΑ2=0.329 ΝΑ2=0.105 ΝΑ2=0.221 ΝΑ3=0·043 ΝΑ3=0.042 ΝΑ3=0.046 ΝΑ3=0.072 ΝΑ4=0.466 ΝΑ4=0.496 ΝΑ4=0.102 ΝΑ4=0.495 ΝΑ5=0.491 ΝΑ5=0.462 ΝΑ5=0.086 ΝΑ5= 0.433 ΝΑ6=0.509 ΝΑ6=0.538 ΝΑ6=0.571 ΝΑ7=0.195 ΝΑ8=0.148 ΝΑ9=0.657 ΝΑ6=0.567 Note: (1) Lowercase a, b, c, d, e, f, g, etc. are time points in seconds. (2) Uppercase eight,; 8, (:, 0, £, ?, 0, etc. are the points on the blood pressure waveform, and the coordinate unit is (mV, sec.) (3) The area parameter (such as AabB) is simplified as The trapezoidal area formed by the four corner points. 45 [Simplified description of the drawings] Fig. 1 is a block diagram of the system of the present invention. Fig. 2 is a view showing an embodiment of the present invention using piezoelectric induction. Fig. 3a is a gas used in the present invention. The relationship between the pressure of the bag and the time is shown in Fig. 3b as a relationship between the blood pressure waveform signal and the air pressure when the present invention is used. 8 3c: Fig. 4 is a diagram showing the waveform of the iliac artery when used in the present invention. Fig. 4 is a piezoelectric sensor used in the present invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 5 is a view showing still another embodiment of the present invention using piezoelectric sensing. FIG. 6 is a view showing still another embodiment of the present invention using piezoelectric sensing. Fig. 8 is a diagram showing the measurement of mean blood pressure by blood pressure pulse wave. Fig. 9a is an exemplary diagram of the radial artery waveform measured by the present invention. Fig. 9b is a diagram showing the use of the present invention Measuring 彳^ artery waveform Exemplary Fig. 9c is a model measured using the present invention. (4) (4) An exemplary diagram 〇 10 1 is the use of the present invention - 3 46 1323652 Fig. 11 is a respiratory waveform pattern measured using the present invention. Fig. 13 is a diagram showing the use of the present invention to detect cough and sneeze using a radial artery pattern. Fig. 14 is a physiological signal used in a hospital isolation ward according to the present invention. Figure 15 is a monitoring system diagram of the present invention for isolating the physiological signals of the people at home. Figure 16 is a further diagram of the use of the present invention. Figure 17 is a handcuff measured using the present invention. Arterial waveform pattern. Fig. 18a is a first-hand deflagration arterial waveform pattern measured by the present invention. Brother 18b is a second-hand radial artery waveform diagram using the present invention> Fig. 19 is a first hand radial artery waveform measured using the present invention. Fig. 20 is a fourth hand dislocation arterial wave measured using the present invention 47 1323652 [Explanation of main component symbols] 1 ' 1 a : Piezoelectric induction 11 : Piezoelectric element 2, 3a : Wrist strap 2a : Monitor main unit 3 : Pump 4 : Vent valve 5 : Air duct 6 : Circuit module 7 : Barometer 8 : Operating software 91 : Power supply 9 : Instrument main unit 8

Claims (1)

Seven, Shen Qing patent scope: a kind of non-&inductive artery wave type ·-wrist band, h person one has. "Including air bag, can be two evil wrists, and - 厌 + 4 added T is applied to the human hand piezoelectric sensor; = help:, the air bag can be inflated; a deflation valve is connected to one end of the air bag; a gas pipe is connected to the air bag; Group, Taiwan ordered right middle blood Μ * + _ ^ has central meter nose, memory, S has operating software inside; a barometer, is connected to the air bag of the air bag; a power supply; and used to The pump and the circuit module include the main body of the instrument; wherein the piezoelectric sensor that can be pressed by the air bag in the wristband is used to sense and measure the brachial artery of the wrist, and can continuously S has recorded and generated a radio wave pattern representing the brachial artery wave; and the steps of measuring the physiological mean blood pressure in the blood pressure (Physiological Mean Blood Pressure) include: measuring with an electronic sphygmomanometer (〇sciu〇metric Method) Systolic blood pressure (SBP) and diastolic blood pressure (DBP); blood pressure waveforms are measured, and The XY plane is plotted, wherein the γ axis is the relative voltage value V, and the X axis is the real time t; the relative voltage average value V(mean) of the above measured blood pressure waveform is calculated by the following formula: 49 1323652 V(mean) = V — t integral value /(t2 — tl).....-.....(1) where V(mean) is the relative voltage average and Vt integral is the Vt waveform at tl (waveform) The integral value in the range from the starting point) to t2 (the end point of the waveform), t2-tl is the time interval of the single waveform, and the physiological mean blood pressure is calculated according to the following formula: PMBP=V(mean)*(SBP- DBP) /(VS- VD).......(2) where PMBP is the physiological mean blood pressure, V(mean) is the relative voltage average, SBP is the systolic blood pressure, DBP is the diastolic pressure, and VS is the maximum blood pressure waveform. Value (peak), VD is the minimum value of the blood pressure waveform (valley); and the physiological mean blood pressure PMBP of each blood pressure waveform is calculated according to the following formula, and then the multiple PMBPs are averaged: PMBP(mean)- SUM( PMBP)/N----.....(3) where PMBP(mean) is the average of the mean mean blood pressure PMBP, SUM (PMBP) is the sum of N PMBPs, and N is the number of blood pressure waveforms. Non-invasive The pulse wave type measuring method has: a wristband containing an air bag, which can be attached to a wrist of a human body and applies pressure to a piezoelectric sensor; a pump can inflate the aforementioned air bag A bleed valve is connected to one end of the air bag; an air guiding pipe is connected to the air bag; a circuit module includes a central calculator, a memory body, and an operating software body therein; 50 1323652 barometer, which is connected to the air pipe of the air bag, · a power source; and the time to - the above-mentioned f-pu and circuit module includes the instrument main body; wherein, the air bag can be used in the wristband The piezoelectric sensor that is pressed is used to sense and measure the wrist around the artery, and can even connect 'only. The radio wave pattern representing the brachial artery wave has been recorded and generated; and the steps for identifying the subject's identity include: the continuity of the test period (such as (four) to 1 minute) to find the starting point of each blood pressure waveform (ie trough), the starting point of the next wave pattern at the end point, and each wave point and trough point; calculate the number of peaks, time, pressure bevel 'area, and normalized (Normal) parameters of each blood pressure waveform Value; calculate the average value of these parameter values during the test period, and define them as the subject's blood pressure waveform characteristic baseline (Characteristic Baseline); Compared with the baseline, if there is a considerable degree of similarity (Similarity), it is determined that the subject is the same person, different people; 'Bei U if there is a group of people (for example, two or more) Feature baseline, if in the future, if the person is connected with an unidentified identity ^ 51 1323652 ', the individual data of the group can be compared according to the blood pressure characteristic parameter value of the subject, and the highest similarity is selected. 'According to This breaking of the test subject that is known to the identity provider; similarity considerably above the so-called 'identification needs to follow the experiment and added to regulate. 3. If the patent application scope is g2 g for the non-invasive radial artery wave measurement method, the step of identifying the identity of the subject is to first calculate the number of peaks in the parameter (generally 丨.〇 to 3.0) and after normalization. (N〇rmalized) The time, pressure, bevel, and area characteristic parameter values are the key parameters that match the similarity. 4. A non-invasive brachial artery wave type measuring method, comprising: a wristband containing an air bag, which can be attached to a wrist of a human body and applies pressure to a piezoelectric sensor; The air bag may be inflated; a gas attack valve is connected to one end of the air bag; an air pipe is connected to the air bag; and a circuit module includes a central calculator and a memory body; Operating a soft body; a barometer connected to the air pipe of the air bag; a power source; and an instrument main body for containing the pump and the circuit module therein; wherein the air bag can be applied by the air bag in the wrist band The piezoelectric sensor is used to sense and measure the wrist around the artery, and can continue to record 52 1323652 and generate a radio wave pattern representing the brachial artery wave; the steps of measuring the respiratory waveform and frequency include: During the test period (such as 1~10 minutes), continuously take the blood pressure waveform of the subject and make a χ Υ map, where χ is time, γ is voltage or pressure; find the main peak of each waveform Depreciation (ie time value) and depreciation (ie voltage or pressure) Force value); create a continuous map as the respiratory waveform of the subject; and take the number of waveforms (eg, eight) per periodic (eg - minute) for the respiratory rate or number of breaths (eg Every suck). _人卞5_ — A non-invasive brachial artery measurement method with: - a wristband containing an air bag that can be attached to the wrist of a human body and exerts pressure on a piezoelectric sensor; Pu, the air bag can be inflated; - the vent valve is connected to one end of the air bag; an air pipe is connected to the air bag; a circuit module, including the middle wheat snoring. . ^ ± ^ ^ . , r 汁 异 异 ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' The main body; 53 1323652 wherein the piezoelectric sensor that can be pressed by the air bag in the wristband is used to sense and measure the brachial artery of the wrist, and can record and generate radio waves representing the brachial artery wave. Wave type; the steps of monitoring the symptoms of coughing or sneezing include: continuously taking the blood wave type of the subject; calculating the three parameter values of the blood pressure wave of the subject in the initial period (such as one minute) (ie, the time interval between the main peak-main peak, the pressure value of the main wave peak, and the pressure value of the main trough) and the standard deviation is defined as the baseline of the three-parameter value; Monitor the three parameter values of the blood pressure waveform. If one (including the above) deviates from the baseline by a predetermined multiple (for example, three times) of the standard deviation, the waveform is called a suspicious irregular data point; rule Feed points occur randomly (non-constant frequency), the data points for the piece goods sense Ow cough or sneeze point; and leaves the system, obtained cough or sneeze wailing frequency (e.g., three times per minute). 6. Two physiological signal monitoring methods for hospital isolation patients include: use a non-invasive brachial artery wave measurement system; • body temperature measurement technology 'and place the temperature sensor in the wristband Jl. One set of wireless transmission transceiver modules is placed in the host, and the other 54 groups are placed in the bedside dividers of the ward that are responsible for receiving the physiological signals of the patients; the heartbeat of the isolated patients is measured by the seven systems. Pressure, diastolic blood pressure, physiological mean blood pressure), respiratory wave pattern and frequency, and determine whether the patient has palpitations, shortness of breath, coughing and snoring; 'Measure the wrist temperature of the patient with the aforementioned temperature sensor, and determine the patient's temperature Whether to have a fever; transmit the above physiological signal to the bedside analyzer by the wireless transmission module; and use the bedside analyzer to pass the patient's physiological signal and its analysis result through the regional J·sheng network (L〇cai Area Network , LAN) or the Internet (Internet) out of the ward; the non-invasive radial artery wave measurement system includes: a wrist ▼ containing an air bag, which can be attached to the human wrist, and a piezoelectric sense Pressing a pump; the pump can inflate the aforementioned air bag; a vent valve is connected to one end of the air bag; a gas pipe is connected to the air bag; a circuit module includes a right towel ^ ^ 3 There is a central measuring device, a memory body, which has an operating software inside, a gas gas, a gas pipe connected to the air bag; a power source; and a device for containing the aforementioned pump and circuit module. The instrument body of the instrument 55; wherein the piezoelectric sensor that can be pressed by the air bag in the wristband is used to sense and measure the radial artery of the wrist, and can continuously record and generate radio waves representing the brachial artery wave. Wave type. 7. For the physiological signal monitoring method for hospital isolation patients, for example, the body temperature measurement technology can be used as a small thermocouple 'a resistive electronic component, or an infrared photoelectric component, three They are all thermal components that convert body temperature into voltage or current signals. 8. For the physiological signal monitoring method for hospital isolation patients, the wireless transmission technology can use the RF (Radi〇FreqUency) wireless module, which can be used in the common ISM. Band (ie [industry, science, medical] shared frequency band). 9. A method for monitoring homes to isolate people, including: using a non-invasive brachial artery wave measurement system; beta measuring the heartbeat of home-occupied people by means of a paradox instrument system, blood pressure (systolic blood pressure, diastolic blood pressure, average Pressure), gold pressure wave type, respiratory wave 5L and frequency and other physiological signals, and judge whether the person has ~ 悸, severe blood pressure changes, shortness of breath, coughing or sneezing; measured by conventional body temperature measurement technology The temperature of the people, according to this to determine whether there is a fever; to know the wireless transmission technology to periodically transmit the physiological information to the 56 1323652 placed in the home signal receiver analyzer; the signal receiving analyzer to store physiological information, analysis (or Displayed) periodically transmitted to the health authority via the Internet (Internet) transmission or telephone modem (Modem); and regularly collected 'collected, and counted the number of unoccupied, already ill, and recovered segregated people; the non-invasive The radial artery wave measurement system includes: a wristband with an air bag that can be attached to the wrist of the human body and a piezoelectric The pump is pressurized; a pump can inflate the aforementioned air bag; a bleed valve is connected to one end of the air bag; a gas pipe is connected to the air bag; and a circuit module includes a central calculation a memory device having an operating software therein; a barometer connected to the air pipe of the air bag; a power source; and an instrument body for containing the pump and the circuit module therein; ίο. The pressure=sensor that can be pressed by the airbag in the wristband is used to sense and measure the brachial artery of the wrist, and can record and generate a radio wave pattern representing the brachial artery wave. : A non-invasive radial artery waveform measurement method, the steps of measuring the heart rate to be different from the autonomic nerve include: (4) extracting the continuous blood pressure waveform of the subject during the test period; 57 (b) selecting the blood pressure waveform (c) Calculate the reference time interval of each waveform; the specific point is the waveform reference point; (d) the point and the next waveform reference point to calculate the test period difference; the average and standard of the internal time interval Bias (4) converts the time interval into a spectrum by the fast Fourier transform method, and calculates the high frequency component, the low frequency component, the very low frequency component, and the total variability; and (f) defines the time interval average value in (d) For the heartbeat cycle, the reciprocal meaning is the heart rate; the standard deviation of the time interval in (d) is defined as the heart rate variability; the heart rate variability in (f) and the total variability in (e) are defined as the representative self-discipline The index of total nerve activity; calculated according to the parameters in (e), lf% (= LF / (LF + HF) * 100 〇 / 〇) and HF% (= HF / (LF + HF) * 100%), and疋% LF% is an indicator of sympathetic activity, hf% is an indicator of parasympathetic activity, and lf/h is defined. f is an indicator of sympathetic-parasympathetic balance. 58