TW256834B - - Google Patents

Info

Publication number: TW256834B
Authority: TW; Taiwan
Prior art keywords: radical; cycloalkyl; alkyl; phenyl; cycloalkylalkyl
Prior art date: 1992-06-24

Application number

TW082107085A

Other languages

English (en)

Inventor

George Wermuth Camille

Original Assignee

Elf Sanofi Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-24

Filing date

1993-08-31

Publication date

1995-09-11

1993-08-31 Application filed by Elf Sanofi Co filed Critical Elf Sanofi Co

1995-09-11 Application granted granted Critical

1995-09-11 Publication of TW256834B publication Critical patent/TW256834B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

TW082107085A 1992-06-24 1993-08-31 TW256834B (zh)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR929207736A FR2692893B1 (fr)	1992-06-24	1992-06-24	Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number	Publication Date
TW256834B true TW256834B (zh)	1995-09-11

Family

ID=9431129

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW082107085A TW256834B (zh)	1992-06-24	1993-08-31

Country Status (30)

Country	Link
US (1)	US5464847A (zh)
EP (1)	EP0576350B1 (zh)
JP (1)	JPH0656809A (zh)
KR (1)	KR100228813B1 (zh)
CN (1)	CN1035552C (zh)
AT (1)	ATE159721T1 (zh)
AU (1)	AU665256B2 (zh)
BR (1)	BR9302643A (zh)
CA (1)	CA2099062A1 (zh)
CZ (1)	CZ125293A3 (zh)
DE (1)	DE69314855T2 (zh)
DK (1)	DK0576350T3 (zh)
ES (1)	ES2110070T3 (zh)
FI (1)	FI932909A (zh)
FR (1)	FR2692893B1 (zh)
GR (1)	GR3025684T3 (zh)
HK (1)	HK1002632A1 (zh)
HU (1)	HUT66384A (zh)
IL (1)	IL106088A (zh)
IS (1)	IS4040A (zh)
MX (1)	MX9303770A (zh)
MY (1)	MY109557A (zh)
NO (1)	NO303118B1 (zh)
NZ (1)	NZ247949A (zh)
PH (1)	PH30921A (zh)
PL (2)	PL176103B1 (zh)
RU (1)	RU2102389C1 (zh)
SG (1)	SG50626A1 (zh)
SI (1)	SI9300337A (zh)
TW (1)	TW256834B (zh)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2714059B1 (fr) *	1993-12-21	1996-03-08	Sanofi Elf	Dérivés amino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
DE4401912A1 (de) *	1994-01-24	1995-07-27	Basf Ag	Methinfarbstoffe in der nichtlinearen Optik
US5646152A (en)	1994-06-15	1997-07-08	Pfizer Inc.	Methods of administering CRF antagonists
US5795905A (en) *	1995-06-06	1998-08-18	Neurocrine Biosciences, Inc.	CRF receptor antagonists and methods relating thereto
FR2735777B1 (fr) *	1995-06-21	1997-09-12	Sanofi Sa	Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
AU703096B2 (en)	1995-10-17	1999-03-18	Neurocrine Biosciences, Inc.	Amino substituted pyrimidines and triazines
US6191131B1 (en)	1997-07-23	2001-02-20	Dupont Pharmaceuticals Company	Azolo triazines and pyrimidines
US7094782B1 (en)	1996-07-24	2006-08-22	Bristol-Myers Squibb Company	Azolo triazines and pyrimidines
US6060478A (en) *	1996-07-24	2000-05-09	Dupont Pharmaceuticals	Azolo triazines and pyrimidines
US6313124B1 (en)	1997-07-23	2001-11-06	Dupont Pharmaceuticals Company	Tetrazine bicyclic compounds
US6124289A (en) *	1996-07-24	2000-09-26	Dupont Pharmaceuticals Co.	Azolo triazines and pyrimidines
US5861398A (en) *	1996-08-26	1999-01-19	Alanex Corporation	Benzoperimidine-carboxylic acids and derivatives thereof
US6159980A (en) *	1996-09-16	2000-12-12	Dupont Pharmaceuticals Company	Pyrazinones and triazinones and their derivatives thereof
FR2754258B1 (fr) *	1996-10-08	1998-12-31	Sanofi Sa	Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
CA2281525A1 (en)	1997-02-18	1998-08-20	Neurocrine Biosciences, Inc.	Biazacyclic crf antagonists
TR200102178T2 (tr)	1998-11-12	2002-01-21	Neurocrine Biosciences, Inc.	CRF reseptör antagonistleri ve bunlarla ilgili yöntemler.
NZ510955A (en)	1998-11-12	2003-01-31	Neurocrine Biosciences Inc	Tricyclic nitrogen containing ring system useful as CRF receptor antagonists
US6531475B1 (en) *	1998-11-12	2003-03-11	Neurocrine Biosciences, Inc.	CRF receptor antagonists and methods relating thereto
FR2796380B3 (fr)	1999-07-15	2001-08-17	Sanofi Synthelabo	Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant
US6432989B1 (en)	1999-08-27	2002-08-13	Pfizer Inc	Use of CRF antagonists to treat circadian rhythm disorders
EP1149583A3 (en) *	2000-04-13	2001-11-14	Pfizer Products Inc.	Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues
US6699866B2 (en) *	2001-04-17	2004-03-02	Sepracor Inc.	Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof
US7276526B2 (en)	2001-07-13	2007-10-02	Bristol-Myers Squibb Pharma Company	Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands
EP1423113A4 (en) *	2001-08-13	2007-04-18	Phenex Pharmaceuticals Ag	NR1H4 NUCLEAR RECEPTOR BINDING COMPOUNDS
EP1285914B1 (en) *	2001-08-13	2007-12-19	PheneX Pharmaceuticals AG	Nr1h4 nuclear receptor binding compounds
JP4484439B2 (ja) *	2002-03-14	2010-06-16	国立大学法人東京工業大学	Ｖｄａｃ調節剤
AU2003213351A1 (en) *	2002-03-14	2003-09-22	Takeda Chemical Industries, Ltd.	Vdac regulator
EA013249B1 (ru) *	2003-12-26	2010-04-30	Киова Хакко Кирин Ко., Лтд.	Производные тиазола
AU2007210014B2 (en) *	2006-02-01	2012-11-01	Merck Sharp & Dohme Corp.	Potassium channel inhibitors
CN101528710B (zh) *	2006-10-19	2012-11-07	弗·哈夫曼-拉罗切有限公司	氨基甲基-4-咪唑类
JP5467735B2 (ja) *	2007-07-02	2014-04-09	東ソー株式会社	円筒形スパッタリングターゲット
RS65839B1 (sr)	2014-01-21	2024-09-30	Neurocrine Biosciences Inc	Crf1 receptor antagonisti za tretman kongenitalne adrenalne hiperplazije
EP3846793B1 (en)	2018-09-07	2024-01-24	PIC Therapeutics, Inc.	Eif4e inhibitors and uses thereof
EP3984523A1 (en)	2018-12-07	2022-04-20	Neurocrine Biosciences, Inc.	Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia
IL296139A (en)	2020-03-03	2022-11-01	Pic Therapeutics Inc	Eif4e inhibitors and uses thereof
WO2023028238A1 (en)	2021-08-25	2023-03-02	PIC Therapeutics, Inc.	Eif4e inhibitors and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4264134A (en) *	1978-05-26	1981-04-28	Elliott Brothers (London) Limited	Display arrangements
DK150068C (da) *	1978-06-02	1987-06-29	Pfizer	Analogifremgangsmaade til fremstilling af aminothiazoler
FR2612187B1 (fr) *	1987-03-12	1989-07-21	Sanofi Sa	Derives du thiazole actifs sur le systeme cholinergique, leur procede de preparation et compositions pharmaceutiques en contenant
US5232921A (en) *	1987-03-12	1993-08-03	Sanofi	Thiazole derivatives active on the cholinergic system, process for obtention and pharmaceutical compositions
FR2656610B1 (fr) *	1989-12-29	1992-05-07	Sanofi Sa	Derives d'amino-2 phenyl-4 thiazole, leur procede de preparation et leur application therapeutique.

1992
- 1992-06-24 FR FR929207736A patent/FR2692893B1/fr not_active Expired - Fee Related
1993
- 1993-06-21 IL IL106088A patent/IL106088A/xx not_active IP Right Cessation
- 1993-06-22 SG SG1996007157A patent/SG50626A1/en unknown
- 1993-06-22 ES ES93401603T patent/ES2110070T3/es not_active Expired - Lifetime
- 1993-06-22 PH PH46390A patent/PH30921A/en unknown
- 1993-06-22 DE DE69314855T patent/DE69314855T2/de not_active Expired - Fee Related
- 1993-06-22 DK DK93401603T patent/DK0576350T3/da active
- 1993-06-22 EP EP93401603A patent/EP0576350B1/fr not_active Expired - Lifetime
- 1993-06-22 AT AT93401603T patent/ATE159721T1/de not_active IP Right Cessation
- 1993-06-22 AU AU41399/93A patent/AU665256B2/en not_active Ceased
- 1993-06-22 NZ NZ247949A patent/NZ247949A/en unknown
- 1993-06-23 JP JP5152479A patent/JPH0656809A/ja active Pending
- 1993-06-23 PL PL93321372A patent/PL176103B1/pl unknown
- 1993-06-23 MY MYPI93001219A patent/MY109557A/en unknown
- 1993-06-23 SI SI9300337A patent/SI9300337A/sl unknown
- 1993-06-23 NO NO932319A patent/NO303118B1/no not_active IP Right Cessation
- 1993-06-23 CA CA002099062A patent/CA2099062A1/en not_active Abandoned
- 1993-06-23 HU HU9301850A patent/HUT66384A/hu unknown
- 1993-06-23 IS IS4040A patent/IS4040A/is unknown
- 1993-06-23 CZ CZ931252A patent/CZ125293A3/cs unknown
- 1993-06-23 RU RU93044129A patent/RU2102389C1/ru active
- 1993-06-23 PL PL93299445A patent/PL174734B1/pl unknown
- 1993-06-23 US US08/080,172 patent/US5464847A/en not_active Expired - Fee Related
- 1993-06-23 MX MX9303770A patent/MX9303770A/es not_active IP Right Cessation
- 1993-06-23 FI FI932909A patent/FI932909A/fi unknown
- 1993-06-23 CN CN93109438A patent/CN1035552C/zh not_active Expired - Fee Related
- 1993-06-24 BR BR9302643A patent/BR9302643A/pt not_active Application Discontinuation
- 1993-06-24 KR KR1019930011709A patent/KR100228813B1/ko not_active IP Right Cessation
- 1993-08-31 TW TW082107085A patent/TW256834B/zh not_active IP Right Cessation
1997
- 1997-12-16 GR GR970403334T patent/GR3025684T3/el unknown
1998
- 1998-02-12 HK HK98101081A patent/HK1002632A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
MX9303770A (es)	1994-05-31
DK0576350T3 (da)	1998-07-20
AU4139993A (en)	1994-01-06
EP0576350A1 (fr)	1993-12-29
KR940000447A (ko)	1994-01-03
SG50626A1 (en)	1998-07-20
PL176103B1 (pl)	1999-04-30
GR3025684T3 (en)	1998-03-31
PL299445A1 (en)	1994-01-24
PH30921A (en)	1997-12-23
FI932909A0 (fi)	1993-06-23
CA2099062A1 (en)	1993-12-25
EP0576350B1 (fr)	1997-10-29
ATE159721T1 (de)	1997-11-15
RU2102389C1 (ru)	1998-01-20
FR2692893A1 (fr)	1993-12-31
FR2692893B1 (fr)	1994-09-02
NO303118B1 (no)	1998-06-02
US5464847A (en)	1995-11-07
JPH0656809A (ja)	1994-03-01
IS4040A (is)	1993-12-25
DE69314855D1 (de)	1997-12-04
AU665256B2 (en)	1995-12-21
HK1002632A1 (en)	1998-09-04
PL174734B1 (pl)	1998-09-30
MY109557A (en)	1997-02-28
IL106088A (en)	1997-09-30
BR9302643A (pt)	1994-01-11
SI9300337A (en)	1994-03-31
CN1085898A (zh)	1994-04-27
HUT66384A (en)	1994-11-28
DE69314855T2 (de)	1998-05-20
CZ125293A3 (en)	1994-01-19
IL106088A0 (en)	1993-10-20
KR100228813B1 (ko)	1999-11-01
NZ247949A (en)	1994-10-26
HU9301850D0 (en)	1993-09-28
FI932909A (fi)	1993-12-25
ES2110070T3 (es)	1998-02-01
NO932319L (no)	1993-12-27
CN1035552C (zh)	1997-08-06
NO932319D0 (no)	1993-06-23

Publication	Publication Date	Title
TW256834B (zh)	1995-09-11
YU166891A (sh)	1994-01-20	Herbicidni supstituisani aril haloalkil pirazoli
MY107655A (en)	1996-05-30	Derivatives of benzofuran,benzothiophene,indole and indolizine,process for their preparation as well as the compositions containing them
DE3874845D1 (de)	1992-10-29	Substituierte triazolinone.
HUT45845A (en)	1988-09-28	Insecticides and acaricides and process for producing 1-aryl-pyrazole derivatives applicable as active ingredient
DE3879653D1 (de)	1993-04-29	Virusinhibierende heterocyclische verbindungen.
EP0485219A3 (en)	1992-10-14	Medicaments for preventing and treating circulatory organ diseases containing spiro-3-heteroazolidine compounds
ATE66221T1 (de)	1991-08-15	Substituierte 5-amino-pyrazole und diese enthaltende fungizide.
DK360388D0 (da)	1988-06-30	Laegemiddel til behandling af hjerteinsufficiens
FI860145A0 (fi)	1986-01-13	Herbicider av typ n-(fosfonometylglycyl)sulfonylaminer.
IL76215A0 (en)	1986-01-31	Benzodisultams,their preparation and their use as herbicides
TW337983B (en)	1998-08-11	1, 3-oxazn-4-one derivatives, their preparation and uses
ES8606862A1 (es)	1986-05-16	Procedimiento para la obtencion de nuevas n-fosforil-o n-tiofosforil-n'-s-triacinil-formamidinas
EP0717045A4 (en)	1996-04-03	METHOD FOR PRODUCING INDOLOCARBAZOL DERIVATIVES
EP0481289B1 (de)	1995-08-02	N-Fumaramidsäurederivate und diese enthaltende Fungizide.

Legal Events

Date	Code	Title	Description
2011-03-11	MM4A	Annulment or lapse of patent due to non-payment of fees