TW201827049A - Orally disintegrating tablet containing diamine derivative - Google Patents

Abstract

Provided is an orally disintegrating tablet containing edoxaban, a pharmacologically acceptable salt thereof, or a solvate thereof. The orally disintegrating tablet contains: (A) edoxaban, a pharmacologically acceptable salt thereof, or a solvate thereof; (B) an organic acid; (C) a water-soluble polymer, the content of which is 0.1-2.0 wt% with respect to the total weight of the tablet; and (D) a disintegrating agent.

Description

   Orally disintegrating tablets containing diamine derivatives   

The present invention relates to an orally disintegrating tablet and a method for manufacturing the same. The orally disintegrating tablet contains edoxaban, a pharmacologically acceptable salt thereof, or a solvate thereof. It disintegrates quickly in water, and has sufficient hardness when generally manufactured, transported, and used.

Lozenges, capsules, granules, powders, and the like are known as dosage forms for oral solid preparations in the field of medicine and food, but development is expected to occur when they are contained in the mouth or when they are placed in water. The orally disintegrating tablet is a dosage form that is easier for elderly people, children, and patients who cannot swallow.

The orally disintegrating tablets need to have sufficient hardness in addition to the characteristics of rapid disintegration in the oral cavity, as well as ordinary tablets, which can withstand physical shocks during manufacture, transportation, and use. In addition, in terms of medication compliance, it is also expected to suppress unpleasant taste, irritation, and have a good taste when contained in the mouth.

There have been various reports on orally disintegrating tablets. For example, Patent Document 1 describes an orally disintegrating tablet containing a drug, a crystalline cellulose having a bulk density of 0.23 g / cm ³ or less, a sugar alcohol, and an alpha starch. However, this document does not describe an orally disintegrating tablet containing edoxaban and an organic acid.

In addition, Patent Document 2 describes an invention of a levofloxacin-containing lozenge containing levofloxacin and hydroxypropylcellulose, which is excellent in water dispersibility and suspendability, but No description is given of an orally disintegrating tablet containing edoxaban, an organic acid, and hydroxypropyl cellulose.

On the other hand, Patent Document 3 describes an invention concerning a coated tablet, which is composed of at least one selected from hypromellose, methyl cellulose, ethyl cellulose, and hydroxypropyl fiber. One or two or more kinds of coating agents such as cellulose and polyvinyl alcohol will contain (a) edoxaban, its pharmacologically acceptable salt, or a solvate of these, (b) selected from sugar alcohols and One or two or more types of water-swellable additives are coated with a pharmaceutical composition having improved dissolution characteristics, and in addition to the above (a) and (b), tablets containing (c) water-swellable additives are coated. Made. However, the object of this document is to obtain a pharmaceutical composition containing edoxaban with improved dissolution properties, and it does not describe a type containing edoxaban and an organic acid that has both high dispersibility and dissolution against water. Sexual oral disintegration tablets.

Patent Document 4 describes a formulation containing (A) edoxaban, a pharmacologically acceptable salt thereof, or a solvate thereof, and (B) an improved dissolution property of an organic acid, but it does not describe a formulation An oral disintegrating tablet that has both high disintegration to water and sufficient hardness to withstand physical shocks during manufacture, transportation, and use.

Prior art literature Patent literature

Patent Document 1 US Patent Application Publication No. 2015/110880

Patent Document 2 Japanese Patent No. 5295506

Patent Document 3 US Patent No. 9149532

Patent Document 4 US Patent No. 9402907

The object of the present invention is to provide an orally disintegrating tablet containing edoxaban, a pharmacologically acceptable salt thereof, or a solvate thereof, which disintegrates quickly when contained in the mouth or when placed in water. , Transportation, use has sufficient hardness, and excellent storage stability.

As a result of intensive studies conducted by the present inventors in order to solve the above-mentioned problems, they found that (A) edoxaban, a pharmacologically acceptable salt thereof, or a solvate thereof, (B) an organic acid, and (C) The water-soluble polymer in which the total weight of the tablet is 0.1 to 2.0% by weight, and the orally disintegrating tablet of the (D) disintegrating agent solve the above problems, and thus completed the present invention.

That is, the present invention provides a composition containing (A) edoxaban, a pharmacologically acceptable salt thereof, or a solvate thereof, (B) an organic acid, and (C) relative to the total weight of the tablet. Orally disintegrating tablets of% water-soluble polymer and (D) disintegrant and method for producing the same.

That is, this invention relates to the following (1)-(24).

(1) An orally disintegrating tablet containing: (A) edoxaban, its pharmacologically acceptable salt, or a solvate thereof, (B) an organic acid, and (C) a total weight relative to the tablet 0.1 to 2.0% by weight of water-soluble polymer and (D) dispersant.

(2) The orally disintegrating tablet according to (1), wherein (B) the organic acid is one or more components selected from the group consisting of fumaric acid, alginic acid, and aspartic acid.

(3) The orally disintegrating tablet according to (1), wherein (B) the organic acid is fumaric acid.

(4) The orally disintegrating tablet according to any one of (1) to (3), wherein the content of the organic acid (B) is 0.1 to 15% by weight based on the total weight of the tablet.

(5) The orally disintegrating tablet according to any one of (1) to (4), wherein (C) the water-soluble polymer is selected from the group consisting of hydroxypropyl cellulose, hydroxypropyl methyl cellulose, One or more components in the group of cellulose based, polyvinylpyrrolidone, and polyvinyl alcohol.

(6) The orally disintegrating tablet according to any one of (1) to (4), wherein (C) the water-soluble polymer is hydroxypropyl cellulose.

(7) The orally disintegrating tablet according to any one of (1) to (6), wherein (D) the disintegrating agent is selected from the group consisting of carboxymethyl cellulose (carmellose) and crospovidone 1 or more of the group consisting of calcium carboxymethyl cellulose, croscarmellose sodium, corn starch, sodium starch glycolate, and alpha starch.

(8) The orally disintegrating tablet according to any one of (1) to (6), wherein (D) the disintegrant is carboxymethyl cellulose, crospovidone, and alpha starch.

(9) The orally disintegrating tablet according to (7) or (8), further comprising a sugar alcohol and a crystalline cellulose having a bulk density of 0.26 g / cm ³ or less.

(10) The orally disintegrating tablet according to (9), wherein the sugar alcohol is D-mannitol.

(11) The orally disintegrating tablet according to any one of (8) to (10), wherein the average degree of α-ization of α-starch is 90% or less.

(12) An orally disintegrating tablet containing: (A) edoxaban, a pharmacologically acceptable salt thereof, or a solvate thereof, (B) an organic acid, (C) relative to the total weight of the tablet 0.1 to 2.0% by weight of hydroxypropyl cellulose, (E) carboxymethyl cellulose, (F) D-mannitol, (G) crystalline cellulose having a bulk density of 0.26 g / cm ³ or less, and (H ) Alpha starch.

(13) The orally disintegrating tablet according to (12), which contains a drug-containing mixed powder or a drug-containing granule, and a drug-free mixed powder; wherein the drug-containing mixed powder or the drug-containing granule contains ( A) edoxaban, a pharmacologically acceptable salt thereof, or a solvate thereof, (B) an organic acid, (C) hydroxypropyl cellulose in an amount of 0.1 to 2.0% by weight based on the total weight of the tablet, and (E) Drug-containing mixed powder or drug-containing granules of carboxymethyl cellulose, drug-free mixed powder containing (F) D-mannitol, (G) Bulk density of 0.26 g / cm ³ or less Drug-free mixed powder of crystalline cellulose and (H) alpha starch.

(14) The orally disintegrating tablet according to (12), which contains a drug-containing mixed powder or a drug-containing particle, and a drug-free particle; wherein the drug-containing mixed powder or the drug-containing particle contains (A ) Edoxaban, its pharmacologically acceptable salts, or solvates thereof, (B) organic acids, (C) hydroxypropyl cellulose in an amount of 0.1 to 2.0% by weight based on the total weight of the tablet, and ( E) Drug-containing mixed powder or drug-containing granules of carboxymethyl cellulose, drug-free granules contain (F) D-mannitol, (G) crystalline fibers with a bulk density of 0.26 g / cm ³ or less And (H) α-starch-free drug-free granules.

(15) The orally disintegrating tablet according to (12), which contains drug-containing particles and drug-free particles, wherein the drug-containing particles contain (A) edoxaban, a pharmacologically acceptable salt thereof, or the Solvates such as (B) organic acids, (C) hydroxypropylcellulose in an amount of 0.1 to 2.0% by weight based on the total weight of the lozenge, and (E) drug-containing particles of carboxymethyl cellulose, The drug-free particles are drug-free particles containing (F) D-mannitol, (G) crystalline cellulose having a bulk density of 0.26 g / cm ³ or less, and (H) alpha starch.

(16) The orally disintegrating tablet according to any one of (12) to (15), wherein (B) the organic acid is selected from the group consisting of fumaric acid, alginic acid, and aspartic acid 1 or more ingredients.

(17) The orally disintegrating tablet according to any one of (12) to (15), wherein the organic acid (B) is fumaric acid.

(18) The orally disintegrating tablet according to any one of (12) to (17), further comprising: a member selected from the group consisting of crospovidone, calcium carboxymethyl cellulose, and croscarmellose One or more ingredients in the group of sodium, corn starch, sodium starch glycolate, and alpha starch.

(19) The orally disintegrating tablet according to any one of (12) to (17), further comprising crospovidone.

(20) The orally disintegrating tablet according to any one of (12) to (19), wherein the organic acid is 0.1 to 15% by weight based on the total weight of the tablet.

(21) The orally disintegrating tablet according to any one of (12) to (20), wherein the crystalline cellulose is 1 to 50% by weight based on the total weight of the tablet.

(22) The orally disintegrating tablet according to any one of (12) to (21), wherein the average degree of α-ization of α-starch is 90% or less.

(23) The orally disintegrating tablet according to any one of (12) to (22), which disintegrated within 60 seconds in a disintegration test.

(24) A method for producing an orally disintegrating tablet, comprising: (A) edoxaban, a pharmacologically acceptable salt thereof, or a solvate thereof, (B) fumaric acid, and (E) ) Carboxymethylcellulose, and spraying hydroxypropyl cellulose (C) dissolved in water with a total weight of 0.1 to 2.0% by weight of the lozenge to produce drug-containing granules; by mixing (F) D-mannitol and (G) crystalline cellulose having a bulk density of 0.26 g / cm ³ or less, and spraying (H) alpha starch which is dissolved or dispersed in water, to produce drug-free granules A step of performing compression molding on the obtained two kinds of particles.

(25) A method for producing orally disintegrating tablets, comprising: (A) Edoxaban, a pharmacologically acceptable salt thereof, or a solvate thereof, (B) fumaric acid, (C ) 0.1 to 2.0% by weight of hydroxypropyl cellulose and (E) carboxymethyl cellulose relative to the total weight of the lozenge, and spraying water to produce drug-containing particles; by mixing ( F) D-mannitol and (G) crystalline cellulose having a bulk density of 0.26 g / cm ³ or less, and spraying (H) alpha starch which is dissolved or dispersed in water, to produce drug-free granules Step; and a step of compression-molding the obtained two kinds of particles.

According to the present invention, there can be provided an orally disintegrating tablet containing edoxaban, a pharmacologically acceptable salt thereof, or a solvate thereof, which has rapid disintegration, solubility, and taste when placed in the mouth or water. Good, with sufficient hardness during general manufacturing, transportation, and use, and excellent storage stability.

Furthermore, according to the present invention, it is possible to provide a manufacturing method that does not require complicated steps or special equipment, and manufactures an orally disintegrating tablet having excellent characteristics as described above by general compression molding.

Forms used to implement the invention

The orally disintegrating tablet according to the present invention is a compression-molded article having rapid disintegration and solubility when contained in the mouth or when placed in water. Specifically, it refers to a disintegration test using saliva mainly in the oral cavity or a disintegration test using a device, which is usually 5 to 180 seconds, preferably 5 to 60 seconds, and more preferably 5 Lozenges that disintegrate within ~ 40 seconds.

The orally disintegrating tablet of the present invention has sufficient hardness during general manufacturing, transportation, and use. For example, in a hardness test, an orally disintegrating tablet having a hardness of usually 2 kg or more, preferably 3 kg or more, and more preferably 5 kg or more.

The orally disintegrating tablet of the present invention maintains dissolution properties suitable for pharmaceuticals. For example, in a dissolution test, an orally disintegrating tablet that shows an average dissolution rate of 80% or more and preferably 85% or more at a 30 minute time point.

Edoxaban used in the present invention is N ^1- (5-chloropyridin-2-yl) -N ² -((1S, 2R, 4S) -4-[(dimethylformate) Ylamino) carbonyl] -2-{[((5-methyl-4,5,6,7-tetrahydrothiazolo [5,4-c] pyridin-2-yl) carbonyl] amino} cyclohexyl) Ethylenediamine (hereinafter, sometimes referred to as Compound 1).

Compound 1 may be a solvate (including a hydrate), or a pharmacologically acceptable salt or a solvate (including a hydrate) thereof. In terms of pharmacologically acceptable salts or solvates thereof, N ^1- (5-chloropyridin-2-yl) -N ² -((1S, 2R, 4S) -4-[(dimethylamino) carbonyl] -2-{[((5-methyl-4,5,6,7-tetrahydrothiazolo [5,4-c] pyridin-2-yl ) Carbonyl] amino} cyclohexyl) ethylenediamine p-toluenesulfonic acid monohydrate (edoxaban tosylate hydrate).

The edoxaban used in the present invention exhibits thrombus inhibition by selectively, reversibly, and directly inhibiting activated blood coagulation factor X (FXa), which is an activated blood coagulation factor X Factors have the effect of generating thrombin from prothrombin in the blood coagulation waterfall and promoting the formation of fibrin, thereby forming a thrombus.

According to clinical trials carried out at home and abroad, edoxaban used in the present invention has been used to include venous thrombosis in patients undergoing lower limb orthopedic surgery for total knee replacement, total hip replacement, and hip fracture surgery. Inhibition of the onset of embolism is also used for the treatment of ischemic stroke and systemic embolism in patients with nonvalvular atrial fibrillation, and for the treatment of venous thromboembolism (deep venous thrombosis and pulmonary thromboembolism) And relapse suppression.

The edoxaban contained in the orally disintegrating tablet of the present invention inhibits the onset of ischemic stroke and systemic embolism in patients with non-valvular atrial fibrillation, and venous thromboembolism (deep venous thrombosis and Pulmonary thromboembolism) treatment and relapse suppression are usually administered to adults once a day with a dose of 30 mg of edoxaban (when the weight is 60 kg or less) or 60 mg (when the weight exceeds 60 kg). . In addition, it can be reduced to 30 mg once a day in response to renal function and concomitant medication. In addition, to suppress the incidence of venous thromboembolism in patients undergoing orthopedic surgery of lower limbs, 30 mg of edoxaban is usually administered orally once a day for adults.

The "acid" in the present invention refers to a compound that exhibits acidity and can be added to pharmaceuticals, and includes organic acids and inorganic acids.

The "organic acid" in the present invention refers to an organic compound exhibiting acidity that can be used as a pharmaceutical additive. Examples of the organic acid include carboxylic acids, sulfonic acids, enols, and salts thereof.

In the present invention, "acidic" means that the pH (hydrogen ion index) in the aqueous solution is less than 7; "neutral" means that the pH is 7.

The inorganic acid used in the orally disintegrating tablet of the present invention is not particularly limited as long as it is an inorganic acid that can be added to pharmaceuticals, and examples thereof include hydrochloric acid and phosphoric acid.

The salt of the inorganic acid used in the orally disintegrating tablet of the present invention is not particularly limited as long as it is a salt of an inorganic acid that can be added to pharmaceuticals, but examples thereof include sodium bisulfite, potassium dihydrogen phosphate, and phosphoric acid. Sodium dihydrogen.

The carboxylic acid used in the orally disintegrating tablet of the present invention is not particularly limited as long as it is a carboxylic acid that can be added to pharmaceuticals, but examples thereof include adipic acid, aspartic acid, alginic acid, benzoic acid, and a carboxyl group. Ethylene polymer, carboxymethyl cellulose, citric acid, glutamic acid, succinic acid, acetic acid, tartaric acid, sorbic acid, lactic acid, hydroxypropylmethylcellulose acetate succinate, butane Adipic acid, maleic acid, malonic acid, anhydrous citric acid, methacrylic acid copolymer, or malic acid; adipic acid, aspartic acid, alginic acid, carboxyvinyl polymer, carboxymethyl Cellulose, citric acid, tartaric acid, hydroxypropyl methylcellulose acetate succinate, fumaric acid, maleic acid, malonic acid, methacrylic acid copolymer, or malic acid; more preferably Examples are aspartic acid, alginic acid, carboxymethyl cellulose, or fumaric acid.

The carboxylic acid salt used in the orally disintegrating tablet of the present invention is not particularly limited as long as it is a carboxylic acid salt that can be added to pharmaceuticals, but examples include sodium L-aspartate, sodium benzoate, and carboxymethyl Sodium starch, potassium carboxymethyl cellulose, calcium carboxymethyl cellulose, sodium carboxymethyl cellulose, sodium dihydrogen citrate, disodium citrate, calcium gluconate, sodium L-glutamate, cross-linked carboxylate Sodium methylcellulose, monosodium succinate, calcium acetate, vinyl acetate resin, sodium tartrate, potassium hydrogen tartrate, potassium sorbate, calcium lactate, monosodium fumarate, sodium fumarate (sodium stearyl fumarate), anhydrous sodium citrate or sodium malate; preferred examples include sodium carboxymethyl starch, potassium carboxymethyl cellulose, calcium carboxymethyl cellulose, sodium carboxymethyl cellulose, and crosslinked carboxylate Sodium methylcellulose or sodium stearyl fumarate; more preferred examples include potassium carboxymethyl cellulose, calcium carboxymethyl cellulose, croscarmellose sodium or stearyl transbutene Sodium disodium.

The enol used in the orally disintegrating tablet of the present invention is not particularly limited as long as it can be added to pharmaceuticals, but examples include ascorbic acid or erythorbic acid; and ascorbic acid is preferred.

The enol salt used in the orally disintegrating tablet of the present invention is not particularly limited as long as it can be added to pharmaceuticals, but examples include sodium ascorbate or sodium erythorbate; preferably, sodium ascorbate is used.

Examples of the carboxylic acid or a salt thereof that is solid at ordinary temperature used in the orally disintegrating tablet of the present invention include adipic acid, aspartic acid, alginic acid, benzoic acid, a carboxyvinyl polymer, and carboxymethyl Cellulose, citric acid, glutamic acid, succinic acid, tartaric acid, sorbic acid, hydroxypropyl methylcellulose acetate succinate, fumaric acid, maleic acid, malonic acid, anhydrous citric acid, Copolymer of methacrylic acid, malic acid, sodium L-aspartate, sodium benzoate, sodium carboxymethyl starch, potassium carboxymethyl cellulose, calcium carboxymethyl cellulose, sodium carboxymethyl cellulose, citric acid Sodium hydrogen, disodium citrate, calcium gluconate, sodium L-glutamate, croscarmellose sodium, monosodium succinate, calcium acetate, vinyl acetate resin, sodium tartrate, potassium hydrogen tartrate, sorbic acid Potassium, calcium lactate, sodium fumarate, sodium stearyl fumarate, anhydrous sodium citrate, sodium malate; preferably adipic acid, aspartic acid, alginic acid, carboxyethylene Polymer, carboxymethyl cellulose, citric acid, tartaric acid, hydroxypropyl methyl cellulose acetate Uronic acid ester, fumaric acid, maleic acid, malonic acid, methacrylic acid copolymer, malic acid, sodium carboxymethyl starch, potassium carboxymethyl cellulose, calcium carboxymethyl cellulose, carboxymethyl Cellulose sodium, croscarmellose sodium or sodium stearyl fumarate; more preferably carboxymethyl cellulose, fumaric acid, potassium carboxymethyl cellulose, carboxymethyl Cellulose calcium, sodium carboxymethyl cellulose, croscarmellose sodium or sodium stearyl fumarate. Preferable examples include aspartic acid, alginic acid, carboxymethyl cellulose, or fumaric acid.

The amount of the acid (appropriately an organic acid) contained in the orally disintegrating tablet of the present invention is not particularly limited, but a person having ordinary knowledge in the technical field to which the present invention belongs may refer to the disintegration test and hardness described in this specification. The criterion of the test is appropriately determined, and rhenium exhibits desired disintegration and hardness. Per 100% by weight of the orally disintegrating tablet, it is preferably 0.1 to 30% by weight, and more preferably 0.1 to 15% by weight.

As for the water-soluble polymer in the present invention, for example, one or two or more combinations selected from the group consisting of hydroxypropyl methyl cellulose, methyl cellulose, hydroxypropyl cellulose, and carboxymethyl may be listed. Cellulose derivatives such as sodium cellulose; synthetic polymers such as polyvinylpyrrolidone, aminoalkyl methacrylate copolymers, carboxyvinyl polymers, polyvinyl alcohol, and polyethylene glycol (macrogol) ; Acacia, agar, gelatin, sodium alginate. As for the water-soluble polymer used in the present invention, cellulose derivatives are preferred, and hydroxypropyl cellulose is even more preferred.

The above-mentioned hydroxypropyl cellulose is not limited as long as it maintains the desired properties (disintegration time, hardness, dissolution) as an orally disintegrating tablet, but for the marketer, for example, it can be exemplified by Soda Japan L grade (viscosity = 6 ~ 10mPa · S) or H grade (viscosity = 1000 ~ 4000mPa · S) sold by the company.

From the viewpoint of moldability and water disintegration and suspension, the content of the water-soluble polymer in the tablets of the present invention is 0.1 to 3.0% by weight per 100% by weight of the orally disintegrating tablets. It is preferably 0.1 to 2.0% by weight, and particularly preferably 0.1 to 0.7% by weight. When the content of the water-soluble polymer is too large, the time required for suspension is prolonged, and the suitability as an orally disintegrating tablet decreases.

The orally disintegrating tablet in the present invention may further include an excipient in addition to the above-mentioned components.

Examples of the excipient include organic excipients selected from sugars, sugar alcohols, starches, celluloses, and inorganic excipients, but sugar alcohols and / or celluloses are preferred.

Examples of the saccharides include one selected from lactose, sucrose, fructooligosaccharides, glucose, palatinose, maltose, reduced maltose, powdered sugar, powdered sugar, fructose, isomerized lactose, and honey sugar Or a combination of two or more.

Examples of sugar alcohols include D-mannitol, erythritol, xylitol, maltitol, sorbitol, and the like, and D-mannitol, erythritol, and xylitol are preferred, and further D-mannitol is preferred. As for D-mannitol, it is generally possible to use a pharmacopoeia that complies with Japan, Europe, and the United States. The crystal form, particle size, and specific surface area of the blended D-mannitol are not particularly limited, but the crystal form may be any of α-type, β-type, δ-type, and amorphous, and the particle size is preferably 10 μm less than 250μm, more preferably 20μm or more to 150μm or less, preferably a specific surface area of 0.1m ² / g or more 4m ² / g or less, more preferably 0.1m ² / g or more 2m ² / g or less; crystal form, size and The specific surface area can be measured by, for example, an X-ray diffraction method, a laser diffraction particle size measurement method, or a BET specific surface area measurement method (multipoint method). Examples of the marketer include D-mannitol such as Merck, Roquette, Towa Chemical Co., and Kao.

The blending amount of the sugar alcohol can be appropriately selected. When D-mannitol is used, it is usually 20 to 95% by weight, preferably 30 to 85% by weight, per 100% by weight of the orally disintegrating tablets.

The sugar alcohol may be directly mixed with other ingredients in a powdered state to form a tablet powder and compression-molded. Alternatively, the sugar alcohol may be granulated using an appropriate binder and then subjected to compression molding.

As for celluloses, in addition to crystalline cellulose, examples thereof include powder cellulose, low-substituted hydroxypropyl cellulose, carboxymethyl cellulose, carboxymethyl cellulose calcium, and cross-linked carboxymethyl fiber. One or a combination of two or more For crystalline cellulose, the bulk density is usually about 0.10 to 0.46 g / cm ³ , preferably 0.10 to 0.42 g / cm ³ , and still more preferably 0.10 to 0.26 g / cm ³ . For the marketer, examples include Ceolus KG-1000 (bulk density 0.10 to 0.15 g / cm ³ ), Ceolus KG-802 (bulk density 0.13 to 0.23 g / cm ³ ), and Ceolus UF-711 (bulk density 0.20). ~ 0.26 g / cm ³ ) (above, manufactured by Asahi Kasei Chemicals). It is also possible to use a combination of two or more crystalline celluloses having different bulk densities and adjust them so as to have a desired bulk density.

The blending amount of the crystalline cellulose per 100% by weight of the orally disintegrating tablet is preferably 1 to 50% by weight. If it exceeds 50% by weight, the fluidity may be deteriorated and the manufacturability may be reduced. A more preferable blending amount is 5 to 30% by weight.

The blending ratio of the crystalline cellulose and sugar alcohol is when D-mannitol is used as the sugar alcohol. The sugar alcohol is 1 to 10 parts by weight, and preferably 1.5 to 8.5 based on 1 part by weight of the crystalline cellulose. It is more preferably 2 to 3 parts by weight.

The crystalline cellulose may be directly mixed with other ingredients in a powder state to form a tablet powder and compression-molded. Alternatively, the crystalline cellulose may be granulated using an appropriate binder and then subjected to compression-molding.

Examples of the starches include one or a combination of two or more selected from the group consisting of corn starch, potato starch, rice starch, and alpha starch.

Examples of the inorganic excipient include one or two or more selected from the group consisting of synthetic hydrotalcite, precipitated calcium carbonate, hydrous silica, light anhydrous silicic acid, magnesium aluminosilicate, and magnesium hydroxide. The combination.

The orally disintegrating tablet in the present invention may further include a disintegrating agent in addition to the above-mentioned components.

Examples of the disintegrating agent include crospovidone (e.g., Japanese Pharmacopoeia conforming product), calcium carboxymethyl cellulose (e.g., Japanese Pharmacopoeia conforming product), carboxymethyl cellulose (e.g., Japanese Pharmacopoeia conforming product), Croscarmellose sodium (e.g., Japanese Pharmacopoeia conforming product), low substitution degree hydroxypropyl cellulose (e.g., Japanese Pharmacopoeia conforming product), corn starch (e.g., Japanese Pharmacopoeia conforming product), sodium starch glycolate (e.g., Japanese Pharmacopoeia (Matching product), and one or more combinations of alpha starch; particularly preferred is selected from the group consisting of crospovidone, calcium carboxymethyl cellulose, carboxymethyl cellulose, and low-substituted hydroxypropyl cellulose And one or more combinations of alpha starch. Further preferred is a combination of carboxymethyl cellulose, crospovidone, and alpha starch.

The α-starch is a product obtained by subjecting starch to a heat treatment, and also includes a part of the α-starch. As for the α-starch, those described in the specifications of Japanese pharmaceutical additives can be used. The average degree of alpha formation is preferably 90% or less, and more preferably 70 to 80%. As a commercial one, for example, α-starch swelstar PD-1 (manufactured by Asahi Kasei Chemicals) can be used.

The blending amount of the α-starch is usually 1 to 15% by weight, and preferably 1 to 10% by weight, per 100% by weight of the orally disintegrating tablet.

The α-starch can be directly mixed with other ingredients in a powdered state to form a tablet powder and compressed, or it can be granulated together with other ingredients and then used for compression molding.

In the orally disintegrating tablet of the present invention, α-starch acts as a disintegrating agent. On the other hand, when it is manufactured, it shows viscosity when dissolved or dispersed in a liquid (for example, water). When the raw material is in a powder state, it can be granulated and granulated. Utilizing this property, a lozenge having good moldability and desired disintegration in the oral cavity can be obtained by spraying a dissolving solution or dispersion solution containing α-starch dissolved or dispersed in water to the containing solution A powdery mixture of crystalline cellulose and sugar alcohol having a bulk density of 0.26 g / cm ³ or less is granulated in a fluidized bed to produce granules, which are mixed with other ingredients and compressed as required. The advantages of such production are the characteristics unique to alpha starch, which are basically not obtained when using conventional dispersants such as hydroxypropyl cellulose with low degree of substitution, crospovidone, and the like.

The blending amount of the disintegrating disintegrating agent is usually 0.5 to 20% by weight, preferably 2 to 20% by weight, per 100% by weight of the orally disintegrating tablet.

The orally disintegrating tablet of the present invention may contain various additives generally used in the manufacture of a tablet as long as the effect of the invention is not impaired.

Examples of the additives include a binder, a lubricant, a coating agent, a plasticizer, a colorant, a flavoring agent, a sweetener, a flavoring agent, a fluidizing agent, a foaming agent, and a surfactant.

Examples of the binding agent include a gum selected from acacia, sodium alginate, a carboxyvinyl polymer, gelatin, dextrin, pectin, sodium polyacrylate, pullulan, methyl cellulose, and hydroxypropyl. One or a combination of two or more of cellulose, hydroxypropylmethyl cellulose, polyvinyl alcohol, polyvinyl pyrrolidone, and polyvinyl glycol.

Examples of the lubricant include magnesium stearate (e.g., Japanese Pharmacopoeia compliance product), calcium stearate (e.g., Japanese Pharmacopoeia compliance product), and sodium stearyl fumarate (e.g., pharmaceutical additive specifications One or two or more combinations of talc (e.g., Japanese Pharmacopoeia conforming product) and talc (especially Japanese Pharmacopoeia conforming product), and magnesium stearate is particularly preferred.

The blending amount of the lubricant is 0.1 to 5.0% by weight per 100% by weight of the orally disintegrating tablet.

Examples of the coating agent covering the surface of the powdered drug (crystallized surface) or the surface of the granulated drug particles include, for example, ethyl cellulose, aminoalkyl methacrylate copolymer E, methyl Acrylic acid copolymer L, dry methacrylic acid copolymer LD, methacrylic acid copolymer LD, methacrylic acid copolymer S, amino alkyl methacrylate copolymer RS, amino alkyl methacrylate copolymer RS, acrylic acid One or a combination of two or more of ethyl ester, methyl methacrylate copolymer, polyvinyl acetal, diethylamino acetate, and polyvinyl acetate resin.

The plasticizer combined with the coating agent may be selected from the group consisting of diethyl sebacate, dibutyl sebacate, triethyl citrate, stearic acid, polyethylene glycol, and triacetin (triacetin) one or a combination of two or more.

As the colorant, for example, food colorants selected from edible yellow No. 5, edible red No. 2 and edible blue No. 2; edible lake pigments, yellow ferric oxide, ferric oxide, titanium oxide, One or a combination of β-carotene and riboflavin.

Examples of the fragrance include one or a combination of two or more kinds selected from citrus, lemon, strawberry, mint, menthol, menthol micron, and various flavors.

Examples of the sweetener include saccharin sodium, saccharin, aspartame, acesulfame potassium, dipotassium glycyrrhizinate, sucralose, and stevia. ) And one or two or more combinations of Somatian.

Examples of the flavoring agent include one or a combination of two or more selected from the group consisting of sodium chloride, magnesium chloride, disodium carnitine, sodium L-glutamate, and honey.

Examples of the fluidizing agent include one type or a combination of two or more types selected from the group consisting of hydrous silica, light anhydrous silicic acid, and talc.

Examples of the blowing agent include tartaric acid and / or anhydrous citric acid.

Examples of the surfactant include polyoxyl 40 stearate, sorbitan fatty acid ester, polyoxyethylene hardened ramie oil, polysorbate, and glyceryl monostearate. One or a combination of two or more esters and sodium lauryl sulfate.

The manufacturing method of the orally disintegrating tablet of the present invention can adopt a well-known manufacturing method for solid preparations. For example, granulation of the main medicine, additives, etc. can be performed, and lubricants can be added and mixed to form tablets. And a lozenge is obtained. After granulation, operations such as drying and granulation can be performed as needed. Hereinafter, one aspect of the orally disintegrating tablet of the present invention (Aspects A and B) and its manufacturing method will be described.

Aspect A: Pharmaceutical-free granules (hereinafter, described as rapidly disintegrating granules) containing crystalline cellulose, sugar alcohol, and alpha starch with a bulk density of 0.26 g / cm ³ or less, and a medicine, or An orally disintegrating tablet obtained by compression-molding granules containing drugs.

In this aspect, the drug-free particles produce a function as a skeleton of the preparation, which can impart desired disintegration and moldability as an orally disintegrating tablet. Granules without drugs, even when blended with only ^{three components} of crystalline cellulose, sugar alcohol, and alpha starch with a bulk density of 0.26 g / cm ³ or less, can exhibit excellent dispersibility and moldability, but they can also be used. Add other additives as needed. In addition, the orally disintegrating tablet in this aspect exhibits further excellent disintegration and dissolution properties by adding a water-soluble polymer and an organic acid in an amount of 0.1 to 2.0% by weight based on the total weight of the tablet.

The manufacturing method of the orally disintegrating tablet of the aspect A includes: a step (A-1) of manufacturing granules containing no drug; a step of manufacturing (A-2) granules containing a drug; and Step (A-3) of mixing the drug-containing particles and other additives and performing compression molding.

    A-1: Steps to make drug-free particles    

Using the following method 1) or 2), drug-free particles can be produced.

1) A method of wet granulating a mixture of crystalline cellulose, sugar alcohol (for example, D-mannitol) and alpha starch with a bulk density of 0.26 g / cm ³ or less using water.

2) Granulate a mixture containing crystalline cellulose with a bulk density of 0.26 g / cm ³ or less and a sugar alcohol (such as D-mannitol) using a liquid obtained by dissolving or dispersing α-starch in water or the like. Method.

For the granulation, a conventional extrusion granulation method, a mixing stirring granulation method, a high-speed stirring granulation method, a fluidized bed granulation method, a rotary granulation method, or the like can be used.

Alpha starch shows viscosity suitable for granulation when dissolved or dispersed in a liquid such as water. Granulation methods include a method of mixing α-starch in a powder state with other ingredients directly and granulating with water, and a method of granulating using a liquid obtained by dissolving or dispersing α-starch in water. . Any of these methods provides a lozenge having desired properties, but the latter method is preferably enumerated.

In addition, in the case of granulation using a solution in which α-starch is dissolved or dispersed, any of the high-speed stirring granulation method and the fluidized bed granulation method can be applied, but in the case of granulation produced by the fluidized bed granulation method, A more excellent orally disintegrating tablet can be obtained. In the case where other additives such as a conventional dispersing agent are blended in the granules not containing a drug, it may be blended in the mixture before granulation.

The blending ratio of the crystalline cellulose and sugar alcohol having a bulk density of 0.26 g / cm ³ or less in the drug-free particles is when D-mannitol is used as the sugar alcohol, with respect to 1 part by weight of the crystalline cellulose. The sugar alcohol is 1.5 to 8.5 parts by weight, preferably 2 to 3 parts by weight.

    A-2: Steps to make drug-containing particles    

The drug can be maintained in a powder state, or granulated as desired, and then mixed with the drug-free particles. The drug-containing granules can be produced, for example, by a conventional extrusion granulation method, a mixing stirring granulation method, a high-speed stirring granulation method, a fluid bed granulation method, or a rotary granulation method.

For example, powdered or granular drugs, organic acids, crystalline cellulose with a bulk density of 0.26 g / cm ³ or less, and sugar alcohols can also be used as a solution obtained by dissolving or dispersing hydroxypropyl cellulose in water. The powder is mixed and granulated to make granules containing drugs. In addition, powdered or granular medicines, organic acids, and mixed powders of crystalline cellulose, sugar alcohols, and hydroxypropyl cellulose with a bulk density of 0.26 g / cm ³ or less can be granulated to form drugs containing water. particle.

In order to mask unpleasant tastes, odors, or dissolution properties such as bitterness or irritation, a drug or a drug-containing particle may be coated. For coating, the aforementioned coating agents and plasticizers can be suitably used. The coating method is performed by using, for example, fluid bed granulation, a coating machine, a rotating fluid bed granulation, a coating machine, a centrifugal flow type granulation, a coating machine, a Wurster type fluid bed granulation, and a coating method. Clothes machine to carry out.

When two or more kinds of drugs are used, the drugs may be contained in the same granules, or may be contained in separate granules, respectively, for compression molding, depending on the blending suitability of each other.

    A-3: The step of mixing the drug-free particles with the drug or drug-containing particles and other additives and performing compression molding    

The orally disintegrating tablets are prepared by mixing the medicine-free particles with the medicine or the medicine-containing particles, and disintegrating agents, lubricants, and other additives as desired, and performing compression molding. Mixing is performed by using, for example, a drum mixer or a convection mixer. The medicine can also be mixed with other additives and used as a medicine-containing mixed powder.

The compression molding of the orally disintegrating tablet of the present invention can be performed using a general tabletting machine. The forming pressure of the tabletting machine can be the same as that of ordinary tablets, and also depends on the shape and size of the tablets, but it is preferably 2 to 20 kN, and more preferably 4 to 14 kN.

The blending ratio of the drug-free particles to the total weight of the lozenge ingredients may be 30 to 90%. In the case where the drug is in a powder form, the blending ratio is 30 to 70%, preferably 30 to 60%. When the medicine is granulated and used, the blending ratio is 30 to 70%, preferably 30 to 60%. In the case of granulating and using a drug, the blending weight of the drug-free particles and the drug-containing particles is preferably 0.5 to 2.0 compared to the drug-containing particles 1.

Aspect B: Oral disintegration obtained by compressive molding of a drug-free mixed powder containing crystalline cellulose, sugar alcohol, and alpha starch with a bulk density of 0.26 g / cm ³ or less, and compression molding with the drug or drug-containing particles ingot.

In this aspect, the drug-free mixed powder provides desired disintegration and formability as an orally disintegrating tablet. The drug-free mixed powder exhibits excellent disintegration and moldability even if it is blended with only ^{three components} of crystalline cellulose, sugar alcohol, and alpha starch with a bulk density of 0.26 g / cm ³ or less. Other additives can be blended as required. In addition, the orally disintegrating tablet in this aspect exhibits further excellent disintegration and dissolution properties by adding 0.1 to 2.0% by weight of a water-soluble polymer and an organic acid.

The manufacturing method of the orally disintegrating tablet of the aspect B includes: a step of manufacturing a drug-containing granule as desired; a step of mixing the drug or the drug-containing granule and other additives and performing compression molding. The procedure for manufacturing the drug-containing particles is the same as that of A-2 described above.

In the step of mixing and compression-molding the drug or the drug-containing particles and other additives, the step of mixing or compression-molding is the same as the above-mentioned A-3.

The orally disintegrating tablet of the present invention thus obtained is excellent in disintegration and solubility when placed in an oral cavity or in water, and is also excellent in physical and chemical stability.

The disintegrating or dissolving properties of the orally disintegrating tablet of the present invention are the disintegrating and dissolving time in the oral cavity (the tablet is in the oral cavity of a healthy adult man, does not contain water in the mouth, and is completely disintegrated or dissolved only under saliva The time until the time is usually 5 to 180 seconds, preferably 5 to 60 seconds, and still more preferably about 5 to 40 seconds.

The orally disintegrating tablets of the present invention are those that are gradually disintegrated or dissolved by saliva when contained in the mouth. The pressure in the mouth, that is, the pressure caused by the palate and the tongue, or the friction caused by the tongue, is " Licking "action, etc., and disintegrate or dissolve in a shorter time. People with dry mouth or low saliva can use water or hot water to disintegrate and dissolve in the mouth, or they can be taken directly with water like ordinary tablets.

On the other hand, the hardness of the orally disintegrating tablet of the present invention has sufficient hardness after a stability test under a certain temperature and humidity condition (for example, temperature 25 ° C, humidity 75%, open system, 1 week).

Therefore, it has hardness that does not disintegrate during the manufacturing process and distribution of the formulation. It has practical hardness even when stored under a certain temperature and humidity conditions, and has excellent storage stability.

The orally disintegrating tablet of the present invention can be used for treating diseases, and can be easily taken by elderly people, children, or patients who cannot swallow, and is also a safe preparation for general adults.

    [Example]    

The following examples are for illustrative purposes and it is not intended to limit the invention to these examples.

    [Comparative Example 1-1]    

In a fluidized bed granulation dryer (Freund, FLO-2), 384.9 g of edoxaban tosylate hydrate, 355.1 g of D-mannitol (Pearlitol 50C, manufactured by Roquette), and crystals were introduced. Cellulose (Ceolus UF-711, manufactured by Asahi Kasei Chemicals Corporation) 95.24 g, 95.24 g of crospovidone (Kollidon CL-F, manufactured by BASF Corporation), and carboxymethyl cellulose (manufactured by Goto Pharmaceutical Co., Ltd., NS-300) 57.14 g, and a combined solution prepared by dissolving 12.38 g of hydroxypropyl cellulose (manufactured by Japan Soda, HPC-H) in 1364 g of purified water was sprayed and dried to obtain granules (containing drug Particles). In a fluidized bed granulation dryer (manufactured by Powrex, GPCG-15), 18480 g of D-mannitol (Roquette, Pearlitol 50C) and 8360 g of crystalline cellulose (Ceolus KG-1000, manufactured by Asahi Kasei Chemical Co., Ltd.) were charged. A liquid obtained by dispersing 1,100 g of α-starch (Swelstar PD-1, manufactured by Asahi Kasei Chemicals) in 12650 g of purified water was spray-dried and dried to obtain granules (rapidly disintegrating granules). Further, 600.0 g of the obtained drug-containing particles, 451.4 g of rapidly disintegrating particles, 68.57 g of crospovidone (manufactured by BASF, Kollidon CL-F), and magnesium stearate (manufactured by Mallinckrodt, HyQual 5712) 22.86 After the g was mixed, the tablets were subjected to tableting with a rotary tableting machine (Kikusui Seisakusho, VIRGO) at a tableting pressure of 5 kN to obtain an orally disintegrating tablet (11 mmφ, 400 mg).

    [Example 1-1]    

392.6 g of edoxaban tosylate hydrate, 384.6 g of D-mannitol (Pearlitol 50C, manufactured by Roquette, Inc.), and crystal fibers were introduced into a fluidized bed granulator dryer (Freund, FLO-2). (95.24 g of Asahi Kasei Chemicals, Ceolus UF-711), 5.714 g of fumaric acid (manufactured by Merck), 57.14 g of crospovidone (Kollidon CL-F, manufactured by BASF), and carboxymethyl cellulose ( 57.14 g (made by Wude Pharmaceutical Co., Ltd., NS-300), and 83.19 g of purified water was dissolved in a binding solution prepared by dissolving 7.619 g of hydroxypropyl cellulose (manufactured by Japan Soda, HPC-H), followed by drying, As a result, granules (drug-containing particles) were obtained. Furthermore, in a fluidized bed granulation dryer (manufactured by Powrex, GPCG-15), 18480 g of D-mannitol (Pearlitol 50C, manufactured by Roquette, Inc.) and 8,360 g of crystalline cellulose (Ceolus KG-1000, manufactured by Asahi Kasei Chemicals) were introduced. A liquid obtained by dispersing 1,100 g of α-starch (Swelstar PD-1, manufactured by Asahi Kasei Chemicals) in 12650 g of purified water was spray-dried and dried to obtain granules (rapidly disintegrating particles). Further, 600.0 g of the obtained drug-containing particles, 437.7 g of rapidly disintegrating particles, 68.57 g of crospovidone (manufactured by BASF, Kollidon CL-F), 13.71 g of sucralose (manufactured by San-EI GEN FFI), and 22.86 g of magnesium stearate (Mallinckrodt, HyQual 5712) was mixed, and then it was tabletted with a rotary tableting machine (Kikusui Seisakusho, VIRGO) at a tableting pressure of 5 kN to obtain an orally disintegrating tablet (11 mmφ, 400 mg).

    [Example 1-2]    

392.6 g of edoxaban tosylate hydrate, 371.2 g of D-mannitol (Pearlitol 50C, manufactured by Roquette, Inc.), and crystalline fibers were charged into a fluidized bed granulation dryer (Freund, FLO-2). (95.24 g of Asahi Kasei Chemicals, Ceolus UF-711), 19.05 g of fumaric acid (manufactured by Merck), 57.14 g of crospovidone (Kollidon CL-F, manufactured by BASF), and carboxymethyl cellulose ( 57.14 g (made by Wude Pharmaceutical Co., Ltd., NS-300), and 83.19 g of purified water was dissolved in a binding solution prepared by dissolving 7.619 g of hydroxypropyl cellulose (manufactured by Japan Soda, HPC-H), followed by drying, As a result, granules (drug-containing particles) were obtained. Furthermore, 18480 g of D-mannitol (Roquette, Pearlitol 50) and 8360 g of crystalline cellulose (Ceolus KG-1000, manufactured by Asahi Kasei Chemical Co., Ltd.) were charged into a fluidized bed granulator dryer (GPCG-15, manufactured by Powrex). A liquid obtained by dispersing 1,100 g of α-starch (Swelstar PD-1, manufactured by Asahi Kasei Chemicals) in 12650 g of purified water was spray-dried and dried to obtain granules (rapidly disintegrating particles). Further, 600.0 g of the obtained drug-containing particles, 437.7 g of rapidly disintegrating particles, 68.57 g of crospovidone (manufactured by BASF, Kollidon CL-F), 13.71 g of sucralose (manufactured by San-EI GEN FFI), and 22.86 g of magnesium stearate (Mallinckrodt, HyQual 5712) was mixed, and then it was tabletted with a rotary tableting machine (Kikusui Seisakusho, VIRGO) at a tableting pressure of 5 kN to obtain an orally disintegrating tablet (11 mmφ, 400 mg).

    [Example 1-3]    

In a fluidized bed granulation dryer (Freund, FLO-2 type), 384.9 g of edoxaban tosylate hydrate, 171.3 g of D-mannitol (Pearlitol 50C, manufactured by Roquette, Inc.), and crystalline fiber were introduced. (95.24 g of Asahi Kasei Chemicals, Ceolus UF-711), 228.6 g of fumaric acid (Merck), 57.14 g of crospovidone (Kollidon CL-F, manufactured by BASF), and carboxymethyl cellulose ( 57.14 g of Wude Pharmaceutical Co., Ltd. (NS-300), and 629.2 g of purified water dissolved in 5.714 g of hydroxypropyl cellulose (manufactured by Japan Soda, HPC-H) are sprayed, dried, and dried This gives granules (drug-containing particles). Furthermore, in a fluidized bed granulation dryer (manufactured by Powrex, GPCG-15), 18480 g of D-mannitol (Pearlitol 50C, manufactured by Roquette, Inc.) and 8,360 g of crystalline cellulose (Ceolus KG-1000, manufactured by Asahi Kasei Chemicals) were introduced. A liquid obtained by dispersing 1,100 g of α-starch (Swelstar PD-1, manufactured by Asahi Kasei Chemicals) in 12650 g of purified water was spray-dried and dried to obtain granules (rapidly disintegrating particles). Further, 600.0 g of the obtained drug-containing particles, 451.4 g of rapidly disintegrating particles, 68.57 g of crospovidone (manufactured by BASF, Kollidon CL-F), and 22.86 g of magnesium stearate (manufactured by Mallinckrodt, HyQual 5712) After mixing, the tablets were compressed with a rotary tableting machine (Kikusui Seisakusho, VIRGO) at a tabletting pressure of 5 kN to obtain an orally disintegrating tablet (11 mmφ, 400 mg).

    [Comparative Example 2-1]    

In a fluidized bed granulation dryer (Freund, FLO-2), 384.9 g of edoxaban tosylate hydrate, 355.1 g of D-mannitol (Pearlitol 50C, manufactured by Roquette), and crystals were introduced. Cellulose (Ceolus UF-711, manufactured by Asahi Kasei Chemical Co., Ltd.) 95.24 g, 95.24 g of crospovidone (Kollidon CL-F, manufactured by BASF Corporation), and carboxymethyl cellulose (manufactured by Goto Pharmaceutical Co., Ltd., NS-300) 57.14 g, and a combined solution prepared by dissolving 12.38 g of hydroxypropyl cellulose (manufactured by Japan Soda, HPC-H) in 1364 g of purified water was sprayed and dried to obtain granules (containing drug Particles). In a fluidized bed granulation dryer (manufactured by Powrex, GPCG-15), 18480 g of D-mannitol (Roquette, Pearlitol 50C) and 8360 g of crystalline cellulose (Ceolus KG-1000, manufactured by Asahi Kasei Chemical Co., Ltd.) were charged. A liquid obtained by dispersing 1,100 g of α-starch (Swelstar PD-1, manufactured by Asahi Kasei Chemicals) in 12650 g of purified water was spray-dried and dried to obtain granules (rapidly disintegrating particles). Further, 600.0 g of the obtained drug-containing particles, 451.4 g of rapidly disintegrating particles, 68.57 g of crospovidone (manufactured by BASF, Kollidon CL-F), and magnesium stearate (manufactured by Mallinckrodt, HyQual 5712) 22.86 After the g was mixed, the tablets were subjected to tableting with a rotary tableting machine (Kikusui Seisakusho, VIRGO) at a tableting pressure of 5 kN to obtain an orally disintegrating tablet (11 mmφ, 400 mg).

    [Comparative Example 2-2]    

In a fluidized bed granulation dryer (Freund, FLO-2 type), 384.9 g of edoxaban tosylate hydrate, 352.3 g of D-mannitol (Pearlitol 50C, manufactured by Roquette, Inc.), and crystalline fiber were introduced. (95.24 g of Asahi Kasei Chemicals, Ceolus UF-711), 5.714 g of fumaric acid (manufactured by Merck), 57.14 g of crospovidone (Kollidon CL-F, manufactured by BASF), and carboxymethyl cellulose ( 57.14 g (made by Wude Pharmaceutical Co., Ltd., NS-300), 63.29 g of purified water, 47.62 g of hydroxypropylcellulose (manufactured by Soda, Japan, HPC-L) was sprayed and dried, As a result, granules (drug-containing particles) were obtained. Furthermore, in a fluidized bed granulation dryer (manufactured by Powrex, GPCG-15), 18480 g of D-mannitol (Pearlitol 50C, manufactured by Roquette, Inc.) and 8,360 g of crystalline cellulose (Ceolus KG-1000, manufactured by Asahi Kasei Chemicals) were introduced. A liquid obtained by dispersing 1100 g of α-starch (Swelstar PD-1, manufactured by Asahi Kasei Chemicals) in 12650 g of purified water was spray-dried, and then dried to obtain granules (rapidly disintegrating particles). Further, 330.0 g of the obtained medicine-containing particles, 248.3 g of rapidly disintegrating particles, 37.71 g of crospovidone (manufactured by BASF, Kollidon CL-F), and 12.60 g of magnesium stearate (manufactured by Mallinckrodt, HyQual 5712) After mixing, a tableting machine (Kikusui Seisakusho, 18HUK) was used to perform tableting at a tabletting pressure of 5 kN to obtain an orally disintegrating tablet (11 mmφ, 400 mg).

    [Comparative Example 2-3]    

In a fluidized bed granulation dryer (Freund, FLO-2 type), 384.9 g of edoxaban tosylate hydrate, 352.3 g of D-mannitol (Pearlitol 50C, manufactured by Roquette, Inc.), and crystalline fiber were introduced. (95.24 g of Asahi Kasei Chemicals, Ceolus UF-711), 5.714 g of fumaric acid (manufactured by Merck), 57.14 g of crospovidone (Kollidon CL-F, manufactured by BASF), and carboxymethyl cellulose ( 57.14 g (made by Wude Pharmaceutical Co., Ltd., NS-300), and 47.62 g of hydroxypropyl cellulose (manufactured by Japan Soda, HPC-H) dissolved in 3,920 g of purified water, sprayed, dried, and dried. This gives granules (drug-containing particles). Furthermore, in a fluidized bed granulation dryer (manufactured by Powrex, GPCG-15), 18480 g of D-mannitol (Pearlitol 50C, manufactured by Roquette, Inc.) and 8,360 g of crystalline cellulose (Ceolus KG-1000, manufactured by Asahi Kasei Chemicals) were introduced. A liquid obtained by dispersing 1,100 g of α-starch (Swelstar PD-1, manufactured by Asahi Kasei Chemicals) in 12650 g of purified water was spray-dried and dried to obtain granules (rapidly disintegrating particles). Further, 330.0 g of the obtained drug-containing particles, 248.3 g of rapidly disintegrating particles, 37.71 g of crospovidone (manufactured by BASF, Kollidon CL-F), and 12.60 g of magnesium stearate (manufactured by Mallinckrodt, HyQual 5712) were further added. After mixing, a tableting machine (Kikusui Seisakusho, 18HUK) was used to perform tableting at a tabletting pressure of 5 kN to obtain an orally disintegrating tablet (11 mmφ, 400 mg).

    [Example 2-1]    

In a fluidized bed granulation dryer (Freund, FLO-2 type), 384.9 g of edoxaban tosylate hydrate, 392.3 g of D-mannitol (Pearlitol 50C, manufactured by Roquette), and crystal fibers (95.24 g of Asahi Kasei Chemicals, Ceolus UF-711), 5.714 g of fumaric acid (manufactured by Merck), 57.14 g of crospovidone (Kollidon CL-F, manufactured by BASF), and carboxymethyl cellulose ( 57.14 g made by Wude Pharmaceutical Co., Ltd. (57-14 g), and a combined solution prepared by dissolving 7.619 g of hydroxypropyl cellulose (manufactured by Japan Soda, HPC-L) in 101.3 g of purified water was spray-dried and dried. As a result, granules (drug-containing particles) were obtained. Furthermore, in a fluidized bed granulation dryer (manufactured by Powrex, GPCG-15), 18480 g of D-mannitol (Pearlitol 50C, manufactured by Roquette, Inc.) and 8,360 g of crystalline cellulose (Ceolus KG-1000, manufactured by Asahi Kasei Chemicals) were introduced. A liquid obtained by dispersing 1,100 g of α-starch (Swelstar PD-1, manufactured by Asahi Kasei Chemicals) in 12650 g of purified water was spray-dried and dried to obtain granules (rapidly disintegrating particles). Further, 330.0 g of the obtained medicine-containing particles, 248.3 g of rapidly disintegrating particles, 37.71 g of crospovidone (manufactured by BASF, Kollidon CL-F), and 12.60 g of magnesium stearate (manufactured by Mallinckrodt, HyQual 5712) After mixing, a tableting machine (Kikusui Seisakusho, 18HUK) was used to perform tableting at a tabletting pressure of 5 kN to obtain an orally disintegrating tablet (11 mmφ, 400 mg).

    [Example 2-2]    

392.6 g of edoxaban tosylate hydrate, 384.6 g of D-mannitol (Pearlitol 50C, manufactured by Roquette, Inc.), and crystal fibers were introduced into a fluidized bed granulator dryer (Freund, FLO-2). (95.24 g of Asahi Kasei Chemicals, Ceolus UF-711), 5.714 g of fumaric acid (manufactured by Merck), 57.14 g of crospovidone (Kollidon CL-F, manufactured by BASF), and carboxymethyl cellulose ( 57.14 g (made by Wude Pharmaceutical Co., Ltd., NS-300), and 83.19 g of purified water was dissolved in a binding solution prepared by dissolving 7.619 g of hydroxypropyl cellulose (manufactured by Japan Soda, HPC-H), followed by drying, As a result, granules (drug-containing particles) were obtained. Furthermore, in a fluidized bed granulation dryer (manufactured by Powrex, GPCG-15), 18480 g of D-mannitol (Pearlitol 50C, manufactured by Roquette, Inc.) and 8,360 g of crystalline cellulose (Ceolus KG-1000, manufactured by Asahi Kasei Chemicals) were introduced. A liquid obtained by dispersing 1,100 g of α-starch (Swelstar PD-1, manufactured by Asahi Kasei Chemicals) in 12650 g of purified water was spray-dried and dried to obtain granules (rapidly disintegrating particles). Further, 600.0 g of the obtained drug-containing particles, 437.7 g of rapidly disintegrating particles, 68.57 g of crospovidone (manufactured by BASF, Kollidon CL-F), 13.71 g of sucralose (manufactured by San-EI GEN FFI), and 22.86 g of magnesium stearate (Mallinckrodt, HyQual 5712) was mixed, and then it was tabletted with a rotary tableting machine (Kikusui Seisakusho, VIRGO) at a tableting pressure of 5 kN to obtain an orally disintegrating tablet (11 mmφ, 400 mg).

    [Comparative Example 3-1]    

Using a mortar, 16.16 g of edoxaban tosylate hydrate, 15.92 g of D-mannitol (Roquette, Pearlitol 50C), and crystalline cellulose (Ceolus UF-711, manufactured by Asahi Kasei Chemical Co., Ltd.) 4.0 g is mixed, whereby a mixture (drug-containing mixed powder) is obtained. 36.08 g of the obtained drug-containing mixed powder and 0.72 g of magnesium stearate (manufactured by Mallinckrodt, HyQual 5712) were mixed, and further 0.1 g of fumaric acid (manufactured by Japan Catalyst) and hydroxypropyl cellulose ( 0.1 g of HPC-L, manufactured by Japan's Soda Co., Ltd. was mixed with a tablet-type tablet molding machine (Ichihashi Seiki, HANDTAB) and tableted at a tabletting pressure of 10 kN to obtain an oral disintegrating tablet (8.0 mmφ, 194 mg).

    [Comparative Example 3-2]    

Using a mortar, 16.16 g of edoxaban tosylate salt hydrate, 15.92 g of D-mannitol (Roquette, Pearlitol 50C), and 4.0 g of crystalline cellulose (Ceolus UF-711, manufactured by Asahi Kasei Chemical Co., Ltd.) By mixing, a mixture (drug-containing mixed powder) is obtained. 36.08 g of the obtained drug-containing mixed powder and 0.72 g of magnesium stearate (manufactured by Mallinckrodt, HyQual 5712) were mixed, and further 0.1 g of crospovidone (manufactured by BASF, Kollidon CL-F) and carboxymethyl fiber were mixed. After mixing 0.1g of vegetarian (manufactured by Wude Pharmaceutical Co., Ltd., NS-300), a tablet-type tablet molding machine (Ichibashi Seiki, HANDTAB) was used for tabletting at a tabletting pressure of 10 kN to obtain an orally disintegrating tablet (8.0 mmφ, 194 mg).

    [Example 3-1]    

392.6 g of edoxaban tosylate hydrate, 371.2 g of D-mannitol (Pearlitol 50C, manufactured by Roquette, Inc.), and crystal fibers (95.24 g of Asahi Kasei Chemicals, Ceolus UF-711), 19.05 g of fumaric acid (manufactured by Merck), 57.14 g of crospovidone (Kollidon CL-F, manufactured by BASF), and carboxymethyl cellulose ( 57.14 g of Wude Pharmaceutical Co., Ltd. (57-14 g), and 839.0 g of purified water dissolved in 7.619 g of hydroxypropyl cellulose (manufactured by Soda, HPC-H) was sprayed, dried, and dried. This gives granules (drug-containing particles). Furthermore, 18480 g of D-mannitol (Roquette, Pearlitol 50) and 8360 g of crystalline cellulose (Ceolus KG-1000, manufactured by Asahi Kasei Chemical Co., Ltd.) were charged into a fluidized bed granulator dryer (GPCG-15, manufactured by Powrex). A liquid obtained by dispersing 1,100 g of α-starch (Swelstar PD-1, manufactured by Asahi Kasei Chemicals) in 12650 g of purified water was spray-dried and dried to obtain granules (rapidly disintegrating particles). Further, 600.0 g of the obtained drug-containing particles, 437.7 g of rapidly disintegrating particles, 68.57 g of crospovidone (manufactured by BASF, Kollidon CL-F), 13.71 g of sucralose (manufactured by San-EI GEN FFI), and 22.86 g of magnesium stearate (Mallinckrodt, HyQual 5712) was mixed, and then it was tabletted with a rotary tableting machine (Kikusui Seisakusho, VIRGO) at a tableting pressure of 5 kN to obtain an orally disintegrating tablet (11 mmφ, 400 mg).

    [Evaluation method]    

The tablets obtained in the examples and comparative examples were evaluated by the following methods.

The tablet thickness and hardness were measured using a fully automatic tablet measuring device (Type WHT-2, PHARMA TEST APPARATEBAU GmbH) (an average value of 20 tablets is described).

The disintegration test refers to the 16th revised edition of the Japanese Pharmacopoeia, the "disintegration test method", and is measured (each maximum value of 6 tablets is recorded).

The dissolution test was performed according to the second method (paddle method, 50 rpm) described in the Japanese Pharmacopoeia. About the dissolution rate, the average dissolution rate of 6 lozenges was calculated. The dissolution test solution (pH 6.0) was used by adding an appropriate amount of a citric acid solution (0.025 mol / L) to a disodium hydrogen phosphate solution (0.05 mol / L) and adjusting the pH to 6.0.

The results are shown in Tables 1 to 5.

    [A brief description of the results]    

Table 1: Compared with the unblended fumaric acid formula as in Comparative Example 1-1, when fumaric acid was blended as in Examples 1-1 to 1-3, it took 60 seconds. Quickly disintegrate within, and exert more excellent functions as an orally disintegrating tablet. In addition, the higher the blending ratio of fumaric acid, the faster the disintegration time and dissolution can be ensured.

Table 2: Compared with the place where the blending amount of fumaric acid is not as in Comparative Example 2-1, and the place where the blending amount of hydroxypropyl cellulose is as shown in Comparative Examples 2-2 and 2-3. In the case where fumaric acid is blended as in Examples 2-1 and 2-2 and the blending amount of hydroxypropyl cellulose is small, it shows a rapid disintegration time within 60 seconds, and exerts As an orally disintegrating tablet, it has more excellent functions. Furthermore, at this time, regardless of the physical properties of hydroxypropyl cellulose, a rapid disintegration time was shown.

Table 3: As in Comparative Example 3-1, even if fumaric acid and hydroxypropylcellulose were blended without disintegrating agents, and as in Comparative Example 3-2, disintegrating agents were blended. Powder without blending fumaric acid and hydroxypropylcellulose. When dispersing agent, fumaric acid, and a small amount of hydroxypropylcellulose were blended as in Example 3-1. Shows rapid disintegration time within 60 seconds, and exerts more excellent functions as an orally disintegrating tablet.

Table 4 and Table 5: The orally disintegrating tablets of Example 4 were produced according to the manufacturing methods described in Examples 1 to 3 and the points described in Table 4. Like Examples 4-1 to 4-9, when edoxaban was blended with fumaric acid, a small amount of hydroxypropyl cellulose, and a dispersant, it showed a rapid disintegration time within 60 seconds. As a more excellent function of orally disintegrating tablets, it can further ensure rapid dissolution.

Tables 6 and 7 show examples of the aspects of the present invention.

Claims (21)

    An orally disintegrating tablet containing: (A) edoxaban, its pharmacologically acceptable salt, or a solvate thereof, (B) an organic acid, and (C) a total weight relative to the tablet 0.1 to 2.0% by weight of water-soluble polymer and (D) dispersant.         The orally disintegrating tablet according to claim 1, wherein (B) the organic acid is one or more components selected from the group consisting of fumaric acid, alginic acid, and aspartic acid.         The orally disintegrating tablet according to claim 1, wherein (B) the organic acid is fumaric acid.         The orally disintegrating tablet according to any one of claims 1 to 3, wherein the content of (B) organic acid is 0.1 to 15% by weight relative to the total weight of the tablet.         The orally disintegrating tablet according to any one of claims 1 to 4, wherein (C) the water-soluble polymer is selected from the group consisting of hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, and polyvinylpyrrole One or more components in the group of pyridone and polyvinyl alcohol.         The orally disintegrating tablet according to any one of claims 1 to 4, wherein (C) the water-soluble polymer is hydroxypropyl cellulose.         The orally disintegrating tablet according to any one of claims 1 to 6, wherein (D) the disintegrant is selected from the group consisting of carmellose, crospovidone, calcium carboxymethyl cellulose , Croscarmellose sodium, corn starch, sodium starch glycolate, and alpha starch in the group of one or more ingredients.         The orally disintegrating tablet according to any one of claims 1 to 6, wherein (D) the disintegrating agent is carboxymethyl cellulose, crospovidone, and alpha starch.     The orally disintegrating tablet according to claim 7 or 8, further comprising a sugar alcohol and a crystalline cellulose having a bulk density of 0.26 g / cm ³ or less.     The orally disintegrating tablet according to claim 9, wherein the sugar alcohol is D-mannitol.     An orally disintegrating tablet containing: (A) edoxaban, a pharmacologically acceptable salt thereof, or a solvate thereof, (B) an organic acid, and (C) a total weight of 0.1 to 2.0 of the tablet Hydroxypropyl cellulose, (E) carboxymethyl cellulose, (F) D-mannitol, (G) crystalline cellulose having a bulk density of 0.26 g / cm ³ or less, and (H) alpha starch. If the orally disintegrating tablet of claim 11 contains a drug-containing mixed powder or a drug-containing granule, and a drug-free mixed powder; wherein the drug-containing mixed powder or the drug-containing granule contains (A) edosa Ban, its pharmacologically acceptable salts, or solvates thereof, (B) organic acids, (C) hydroxypropyl cellulose in an amount of 0.1 to 2.0% by weight based on the total weight of the tablet, and (E) carboxymethyl Base cellulose-containing drug-containing mixed powder or drug-containing granules, and drug-free mixed powders contain (F) D-mannitol, (G) crystalline cellulose having a bulk density of 0.26 g / cm ³ or less, and (H) A non-medicated mixed powder of alpha starch. If the orally disintegrating tablet of claim 11 contains a drug-containing mixed powder or a drug-containing particle, and a drug-free particle; wherein the drug-containing mixed powder or drug-containing particle contains (A) edoxaban , Its pharmacologically acceptable salts, or solvates thereof, (B) organic acids, (C) hydroxypropyl cellulose in an amount of 0.1 to 2.0% by weight based on the total weight of the tablet, and (E) carboxymethyl Cellulose drug-containing mixed powder or drug-containing granules, drug-free granules contain (F) D-mannitol, (G) crystalline cellulose with a bulk density of 0.26 g / cm ³ or less, and (H ) Drug-free granules of alpha starch.     The orally disintegrating tablet according to any one of claims 11 to 13, wherein (B) the organic acid is one or more components selected from the group consisting of fumaric acid, alginic acid, and aspartic acid.         The orally disintegrating tablet according to any one of claims 11 to 13, wherein (B) the organic acid is fumaric acid.         The orally disintegrating tablet according to any one of claims 11 to 15, further comprising: selected from the group consisting of crospovidone, calcium carboxymethylcellulose, croscarmellose sodium, corn starch, glycolic acid One or more ingredients in the group of sodium starch and alpha starch.         The orally disintegrating tablet of any one of claims 11 to 15, further comprising crospovidone.         The orally disintegrating tablet according to any one of claims 11 to 17, wherein (B) the organic acid is 0.1 to 15% by weight relative to the total weight of the tablet.         The orally disintegrating tablet according to any one of claims 11 to 18, which disintegrates within 60 seconds in a disintegration test.     A method for producing orally disintegrating tablets, comprising: mixing (A) edoxaban, a pharmacologically acceptable salt thereof, or a solvate thereof, (B) fumaric acid, and (E) carboxymethyl A step of producing a drug-containing particle by spraying (C) dissolved in water with respect to the total weight of the lozenge of 0.1 to 2.0% by weight of hydroxypropylcellulose; D-mannitol and (G) crystalline cellulose having a bulk density of 0.26 g / cm ³ or less, and spraying (H) alpha starch which is dissolved or dispersed in water to produce granules without drugs; And a step of compression-molding the obtained two kinds of particles. A method for producing orally disintegrating tablets, comprising: mixing (A) edoxaban, a pharmacologically acceptable salt thereof, or a solvate thereof, (B) fumaric acid, and (C) relative to The total weight of the lozenge is 0.1 to 2.0% by weight of hydroxypropyl cellulose and (E) carboxymethyl cellulose, and spraying water to produce granules containing drugs; by mixing (F) D-mannose Sugar alcohol and (G) crystalline cellulose having a bulk density of 0.26 g / cm ³ or less, and spraying (H) alpha starch which is dissolved or dispersed in water to produce granules without drugs; and The two kinds of particles are subjected to a compression molding step.