TW201506402A - Autologous moisture-proof inspection chips and the manufacturing method thereof - Google Patents

Abstract

Autologous moisture-proof inspection chips and the manufacturing method thereof are disclosed, which mainly include a sheet-like butt joint pad having a first end and a second end, a sample pad used to receive a specimen being sinking in, a reactant releasing pad having a reactive material in reaction to the specimen, an outcome display pad indicating the result of specimen's reaction with the reactive material, and a liquid absorbing sheet, all being arranged in sequence. The liquid absorbing sheet is mainly consisted by agents capable of absorbing water so as to absorb the excess water remains overflowing from the sample pad when the specimen being inspected, moreover, the liquid absorbing sheet is able to keep the package free from humidity before the package being opened, therefore, an autologous moisture-proof function is provided.

Description

Self-defense inspection chip and manufacturing method thereof

The invention relates to an inspection chip and a manufacturing method thereof, in particular to an inspection chip with self-dehumidifying and moisture-proof capability and a manufacturing method thereof.

In recent years, due to the development of medical device technology, home physiological signal measuring instruments have become more and more popular. For example, a sphygmomanometer, an electronic thermometer, a blood glucose meter, a uric acid monitor, a cholesterol tester, a mini electrocardiograph, etc. Different physiological signal measuring instruments have different prices and different practicalities.

Some physiological signal measuring instruments must collect blood for measurement. Therefore, it must be measured with medical test papers that already contain enzymes, such as blood sugar, uric acid, total cholesterol, low-density lipoprotein, high-density lipoprotein, liver. Test of functional index, triglyceride, etc. Although instruments using medical test strips are easy to store and maintain, medical test strips themselves are not easy to store.

The reason why medical test paper is difficult to store is that the enzyme in the medical test paper is hydrolyzed by absorbing moisture in the air, which causes the medical test paper to fail. Therefore, the medical test paper itself needs to be preserved through a medical test paper bottle or a package material having a good sealing effect, and even a dry test bag must be placed in the medical test paper bottle or the package material.

However, the cost of the medical test paper bottle package is high, and once the bottle is opened, all the medical test papers will face the problem of moisture, and the user must use it within a certain period of time, or store it in a moisture-proof box, but It will become a problem that must be kept in a centralized manner and is not convenient enough to use.

The Republic of China Patent Publication No. M419571 "Capsule Type Medical Test Paper Package" proposes a capsule type medical test paper package comprising a substrate, at least one desiccant layer, and at least one medical test paper. among them, The substrate comprises a plurality of capsule structures, each capsule structure comprising an observation window; the desiccant layer is a material that is discolored after moisture absorption, and is disposed on an inner surface of each capsule structure. However, although the moisture situation can be easily observed, the cost of such packaging materials will be greatly increased.

Other more common packages are desiccants placed in a package at the same time, but this will increase the cost, and the content space of the package must satisfy the volume of the desiccant package, so that the shape of the package If it is enlarged, it is impossible to make the body shape of the package in close proximity to the body shape of the test piece, so that the space for the push is occupied.

The main object of the present invention is to provide a test chip having a self-moisture-proof ability before the package is activated, and a manufacturing method thereof, which mainly utilizes a water-absorbing sheet mainly composed of an element capable of absorbing moisture, in addition to utilizing the guiding ability thereof. And the water absorption provides the absorption of the residual liquid of the sample, and before the encapsulation is enabled, the moisture remaining in the air around the inspection chip in the package body can be absorbed by itself to ensure the maintenance of the dryness of the chip, and the process of the prior art is complicated and increased. The cost of the dehumidification component is high, and the water absorption sheet is assembled synchronously with each component, and the inspection chip production and packaging rate with the self-moisture resistance can be improved, and the body shape of the package can be reduced to be close to the compact shape of the test piece. Encapsulation.

Based on the above object, in the inspection chip of the present invention and the manufacturing method thereof, the inspection chip mainly comprises a sheet-shaped flat mat having a first end and a second end, and a sample pad for receiving a sample infiltration, having a relative to the inspection The result of the reaction release pad of the bulk reaction material, the result of the reaction of the reaction material presenting the sample, and the arrangement of the water absorption sheet sequence arrangement. The water absorption film is mainly composed of a material capable of absorbing moisture, so as to utilize the water absorption property to provide excess water for the sample, and before the opening is enabled, the residual moisture in the air around the inspection chip can be absorbed in the package body. In order to avoid damage to the test chip, and because the water absorption film is the necessary component, it will not increase the number of components, but will reduce the same desiccant package that is usually stored in the package, thus reducing the cost.

Another object of the present invention is that the water body absorption sheet can be woven into a three-dimensional block by hydrophilic fibers. Or a sheet-like body in which a hygroscopic dry material is mixed, which may be filled with an interlayer, or combined with a hydrophilic fiber before being formed into a wire, and is mainly capable of contacting air, and can absorb residual moisture in the air inside the package.

In another aspect of the present invention, in order to produce, a linear production line is arranged, and according to the running line of the flat mat, the parallel and constant speed of the sample mats, the release mats, the display mats, and the like are simultaneously combined with the strips. The water body absorption sheet is combined with a cutting device in front of the end of the running line, and the width of the finished product is determined according to the change of the cutting frequency.

The advantages and spirit of the present invention will be further understood from the following detailed description of the invention.

1‧‧‧Lateral flow test strip

10‧‧‧Adhesive card

101‧‧‧ first end

102‧‧‧ second end

20‧‧‧Sample pad

30‧‧‧Rejugated pad

40‧‧‧ Results display mat (Membrane)

50‧‧‧Absorbent pad

51‧‧‧汲引路径

100‧‧‧Flat mat

200‧‧‧sample pad

300‧‧‧Reactant release pad

400‧‧‧ Results show litter belt

500‧‧‧Band water absorption film

600‧‧‧Package

7‧‧‧ Cutting device

The first figure is a schematic diagram of the self-proof moisture proof inspection chip of the present invention.

The second figure is a schematic diagram of a method for manufacturing an auto-moisture proof test chip of the present invention.

Please refer to the first figure. The first figure is a schematic cross-sectional view of the self-moisture proof test chip of the present invention. As shown in the first figure, the Latral flow test strip 1 of the present invention mainly comprises a flat pad 10 having a first end 101 and a second end 102 for inspection. The result of the reaction of the sample infiltrated sample pad 20, the reactant releasing pad 30 having the reaction substance with respect to the sample, and the reaction substance presenting the sample shows the pad 40 and the water-absorbent sheet 50.

Here, the sample pad 20 is formed at the first end 101 of the flat mat 10; the reactant release pad 30 is formed on the flat mat 10 and has contact with the sample pad 20; as a result, the display pad 40 is formed at The mat 10 is in contact with the reactant release pad 30; the water suction pad 50 is formed on the second end 102 of the flat mat 10 and is guided through the guiding path 51 to allow the sample pad 20 to seep through The water liquid can be sucked into the water body absorbing sheet 50 along the guiding path 51. However, the guiding path 51 is formed by at least a combination of the water body absorbing sheet 50 and the result display mat 40.

When the sample is dropped from the sample pad 20, since the water body absorption sheet 50 is mainly absorbed by the water body The composition of the medicinal material, so that the water absorbing sheet 50 can mainly provide the capillary and the relative passage of the sample by using the water absorbing property to form the capillary flow 汲 gravitational force, and the sample is gradually diffused to the result display pad 40, and in the process, the sample is allowed to be taken. The reaction material with respect to the sample contained in the reactant release pad 30 is reacted, and in accordance with the original design of the test chip 1, the result shows that the mat 40 shows a reaction result (for example, a strip having a color).

In order to allow the specimen to be smoothly attracted, at least between the water absorbing sheet 50 and the result display pad 40, a guiding path 51 is established to provide the capillary flow attraction of the specimen by the water absorbing property of the water absorbing sheet 50, and the indicated The water absorbing sheet 50 is mainly composed of a three-dimensional block or sheet-like body composed of a water-absorbent polymer compound, and the three-dimensional constituent elements are required to have a siphon capillary phenomenon, and a filament is used. For weaving, the water-absorbing molecules can be filled in the fiber gap, or compounded by interlayer, or mixed before the fiber is drawn, compounded in the rubber, and made to be in contact with ambient air, and the adsorbed package 600 is packaged. Excessive moisture remaining inside.

In order to solve the problems of complicated process and high cost in the prior art, the water absorption sheet 50 can simultaneously absorb the air in the air around the inspection chip 1 in order to solve the problem that the conventional drying method is packaged together in the package material. Water vapor becomes a suitable way to provide moisture-proof mechanisms in products such as the class.

In addition, the water-absorbing sheet 50 has a geometric three-dimensional shape, and can absorb moisture in the air around the test chip 1, such as a block, a sheet, a strip, and the like.

The water-absorbing sheet 50 can be, for example, a sheet-like desiccant, a film desiccant or a dry paper. Further, the material of the water absorption sheet 50 may be selected, and the portion having the dehumidification function may include one of the following groups or any combination thereof: (1) a compound which can react with water, for example, calcium chloride, calcium oxide, phosphoric anhydride, (2) A substance having high water absorbability, for example, silicone rubber, polymer polymer, sugar cane fiber, montmorillonite, and activated carbon.

In order to provide a full utilization of the water-receiving sheet 50, the self-shielding inspection chip 1 may be mounted by covering the casing, and the outer casing of the inspection chip 1 may be a Cassette structure or a pen type (Midstream) The outer shell of the structure, and the shape of the water-absorbing sheet 50 may be a strip-shaped strip chip, or a sheet-like shape, or a roll-shaped finished product to be slit.

Please refer to the second figure. The second figure shows the manufacturing method of the self-moisture proof test chip of the present invention. intention. As shown in the second figure, in the manufacturing method of the self-moisture proof test chip of the present invention, firstly, a flat mat material tape 100 having a first end 101 and a second end 102 is provided, and then the sample mat tape 200 is reacted. The release liner strip 300, the result shows that the dunnage strip 400, the strip-shaped water-absorbent sheet 500 are sequentially formed on the flat mat strip 100 to form an uncut lateral flow test sheet. . Next, a plurality of inspection chips 1 which are slit are formed by cutting. The cut inspection chip 1 or the roll-form semi-finished product is packaged by the package 600, and the package operation also includes the inspection chip 1 being packaged after being inserted into the cassette or the test pen case.

Wherein, in the uncut strip test chip, the sample bead tape 200 is formed on the first end 101 of the flat mat strip 100, and the sample bead tape 100 is used to accept penetration of the sample. The reactant release pad strip 200 has contact with the sample pad strip 200. The reactant release pad strip 300 has a reactive species relative to the sample. The results show that the litter tape 400 is in contact with the release of the reactants, and the results show that the bedding tape 400 can present the reaction of the reactive species of the sample. The belt-shaped absorbent moisture absorption 500 has contact with the result display pad, and the belt-shaped water body absorption sheet 500 is mainly composed of a water body absorbent material to provide the capillary flow 汲 gravitational force of the sample by utilizing water absorption, and the test chip 1 is in the push In the state of being encapsulated by Chen, the inside of the package is absorbed, and the moisture in the air around the test chip 1 is examined.

The features and spirit of the present invention will be more apparent from the detailed description of the preferred embodiments. On the contrary, the intention is to cover various modifications and equivalents within the scope of the invention as claimed.

1‧‧‧ Self-defense inspection chip

10‧‧‧Seat mat

101‧‧‧ first end

102‧‧‧ second end

20‧‧‧ sample pad

30‧‧‧Reactant release pad

40‧‧‧ Results display pad

50‧‧‧Water body absorption film

Claims (10)

The invention relates to a self-moisture proof test chip, comprising: a sample pad for receiving infiltration of a sample; a reactant release pad, one end contacting the sample pad, and having a reaction substance relative to the sample; a display pad, one end is in contact with the reactant release pad, and is used to present the reaction result of the reaction substance of the sample; and a water body absorption sheet, one end is in contact with the result display pad, and the absorption piece is mainly absorbed by the water body. The composition of the agent has a capillary effect, and at least conducts the result display pad indirectly through a guiding path, provides capillary flow 对该 attraction to the sample, and absorbs air in the package surrounding the inspection chip at least in an encapsulated state. The moisture in the water. The self-moisture-proof inspection chip according to claim 1, wherein at least a guiding path is established between the water absorption sheet and the sample pad to provide the sample by utilizing the water absorption of the water absorption sheet. Capillary flow 汲 gravitation. The self-moisture proof test chip of claim 1, wherein the water-absorbing sheet has a geometric three-dimensional shape and absorbs moisture in the air surrounding the test chip. The invention relates to a self-moisture-proof inspection chip, comprising: a flat-shaped flat mat having a first end and a second end; a sample pad formed on the first end of the flat mat and configured to receive a sample a reactant release pad formed on the mat mat and having contact with the sample pad and having a reactive substance relative to the sample; a result display pad formed on the flat mat and having contact with the reactant release pad and presenting a reaction result of the reaction substance of the sample; and a water absorption sheet formed on the flat The second end of the mat is in contact with the result display mat, and is mainly composed of a desiccant material absorbed by the water body, having a capillary effect to provide the capillary flow attractive force of the specimen by utilizing water absorption while at least absorbing the Check the moisture in the air around the chip package. The self-moisture-proof inspection chip according to claim 4, wherein at least a guiding path is established between the water-absorbing sheet and the sample pad to provide the sample by utilizing the water absorption of the water-absorbing sheet. Capillary flow attraction. The self-moisture proof test chip of claim 4, wherein the water-absorbing sheet has a geometric three-dimensional shape and absorbs moisture in the air surrounding the test chip. The self-moisture-proof test chip according to claim 1 or 4, wherein the water-absorbing sheet is a sheet-like desiccant, a film desiccant or a dry paper. The self-moisture proof test chip according to claim 1 or 4, wherein the outer package of the test chip may be a Cassette structure, a stripe type, a Midstream structure, a chip semi-finished product, and a roll. Construction semi-finished or capsule type. A method for manufacturing a self-moisture proof inspection chip, comprising: providing a flat mat with a first end and a second end; and a sample bedding tape, a reactant release pad, and a result display pad A belt-shaped water-absorbing sheet is sequentially bonded to the flat mat strip to form an uncut strip-shaped inspection chip; wherein, in the strip-shaped inspection chip, the sample-pad is bonded At the first end of the flat gasket strip, and with the sample bead tape, an infiltration of a sample is received, the reactant release pad having contact with the sample bead tape, and The reactant release pad has a reactive material relative to the sample, the result showing that the pad has contact with the reactant release pad, and the result indicates that the pad can present the reactive material of the sample As a result of the reaction, the strip-shaped water-absorbing sheet has contact with the result to show a mat strip, and the strip-shaped water-absorbing sheet is mainly composed of a desiccant material to provide the capillary flow attraction of the specimen by utilizing water absorption while absorbing The water vapor in the air surrounding the test chip. The method for manufacturing an auto-moisture-proof inspection chip according to claim 9, wherein the manufacturing method further comprises: cutting the un-cut strip-shaped inspection chip to form a plurality of inspection chips.