TW201014571A - Optical coherence tomography device, method, and system - Google Patents

Abstract

Optical coherence tomography (OCT) devices, methods, and systems are disclosed for detecting, monitoring, and/or measuring ophthalmic conditions and/or characteristics. In accordance with one aspect of the present invention, an OCT system can be configured to perform self-administered tests to monitor and/or detect at least one ophthalmic condition of the user. In one example, the OCT system can be configured to perform periodic self-administered tests to monitor a chronic eye disease or ophthalmic condition of the user over a period of time. In another example, the OCT system performs self-administered tests to screen for glaucoma, such as narrow angle glaucoma and open angle glaucoma.

Description

201014571 VI. Description of the Invention: [Technical Field of the Invention] [0001] Embodiments of the present invention relate to the field of optical coherence tomography (OCT), and in particular to the use of optical coherence tomography data. A device, system, and method for performing accurate measurement of eye tissue to detect eye diseases. [Prior Art] [0002] Optical coherence tomography has been applied in industrial, medical or other fields, and is generally referred to as interferometric, non-invasive optical tomographic imaging technique. To provide millimeter-level perspective force with micron-scale axial and lateral resolution (approximately 2_3 in tissue). For example, in medical applications, doctors usually want to have non-invasive, in vivo imaging technology (in vivo) Imaging technique) ' to obtain subsurface, cross-section and/or three-dimensional images of translucent and/or opaque substances under conditions equivalent to low power microscopes. Therefore, in the next few years, every year Twenty million optical tonal tomography scans will be performed on patients, most of which may occur in the field of ophthalmology (〇phthalm〇1〇gy). For current optical coherence tomography systems, doctors or Other medical professional is at the doctor's clinic (medical 〇ffice) or medical facility (medicalfaciliti) Optical coherence tomography is performed in es) [Invention] [003] Embodiments of the present invention are related to optical coherence tomography, which generally refers to interferometric, non-invasive optical tomography. Imaging techniques that can be used to make, measure, and/or analyze ophthalmology or symptoms. According to one aspect of the present invention, an optical coherence layer photographic scanning system can be used to perform self-administered Test behavior to monitor a chronic eye disease (chr〇nic (4)) 201014571 • or ophthalmic condition. In another embodiment, the optical coherence tomography system performs self-administration test behavior, selected by Xue (screen a type of glaucoma (V), such as a narrow angle glaucoma or an open angle glaucoma [0004] In one embodiment, a chronic ophthalmologic optical tonal tomography measurement and monitoring The system includes an optical coherence tomography measuring device for measuring at least one ophthalmic characteristic of at least one eye of a user. Coherent tomography measurements can be used to allow the user to self-manage measurement behavior using an optical coherence tomography measurement device. The optical coherence tomography and monitoring system also includes a processor to compare the measured ophthalmic characteristics. At least one user who has been previously stored in a storage medium has previously measured ophthalmic characteristics. The processor can be further configured to determine the difference between the measured ophthalmic characteristics and the previously measured ophthalmic characteristics. When the difference satisfies at least one criterion, the processor can also be used to determine an increased probability of needing treatment. In addition, the optical coherence tomography and monitoring system further includes an output device </ RTI> for generating an output to the user, and the processor is further operative to generate the output on the output device based on the difference. [0005] In one embodiment, a method for self-administering an optical coherence tomography test behavior to monitor an ophthalmic condition, including receiving information about an ophthalmic condition, using a Q-optical coherence tomography instrument to obtain at least one use The optical coherence tomography measurement of the eye, the ophthalmic output related to the state of the ophthalmic symptom according to the scanning result of the optical coherence tomography, and the output of the ophthalmic symptom to the user, a health care provider (healthcare provider) And an agent of the healthcare provider. [0006] In an embodiment, an optical coherence tomography system includes an input device for receiving information related to an ophthalmologic symptom ( Input device ), an eyepiece for receiving at least one eye of a user, a light source for outputting light from the eyepiece to the eye of the user, Optical interference from the light reflected by the user's eyes (optical interferenc An interferometer 201014571 (interferometer), an optical detector arranged to detect the aforementioned optical interference, and an electronic device coupled to the optical detector for analysis by interference a plurality of optical tomographic tomography measurements (0CT measurements) obtained by the instrument, and an ophthalmic rotation associated with a state of ophthalmic symptoms, and an output device electrically connected to the electronic device, the output device for outputting an ophthalmology Output. In one embodiment, a self-administered optical coherence tomography system for detecting glaucoma includes an optical coherence tomography (OCT measurement device) for obtaining a user's eye. A first set of optical coherence tomography data (OCT data) of a region (regi〇n) and a second set of optical coherence tomography data of a second region of the eye. The first and second regions of the eye can be located at different anterior-posterior depths. An optical coherence tomography measurement device can also be used to allow the user to self-manage the scanning behavior using the device. A self-administered optical coherence tomography system for detecting glaucoma also includes a processor for using a first set of optical coherence tomography data to determine a first boundary position (bountiajyposition) and a second set of optical coherence tomography Information to determine a second boundary location. The processor may be further configured to determine an ophthalmic distance according to the first boundary position and the second boundary position, and compare the eye distance with a threshold value (thfesh〇id value) to select glaucoma in the eye . The self-administered optical coherence tomography system for glaucoma also includes an output device for generating an output on the output device based on the aforementioned comparison. [0008] In an embodiment, a species for providing self-management optical coherence (4) m rows of fine side (four) eyes to a user's eyes, including a smoke-optical tomography scanner If (OCT instrument) At least - the optical coherence tomography measurement of the anterior segment of the user's eye, according to the optical coherence tomography Z-inserted mosquito-and-green-related state-related ophthalmic rotation, and the output ophthalmology 2 to the user, One of the lesser providers of health bribes and health care providers. The following is a summary of the features, advantages and novel features of the technical features disclosed in the above description of the invention. It is to be understood that all of the above-mentioned aspects, advantages and features may be implemented and/or achieved without corresponding to the specific embodiments of the invention. Thus, the skilled in the art, for example, may find that the invention may be implemented in a manner that achieves one or more of the advantages disclosed herein, but does not necessarily achieve other advantages as taught or suggested herein. [Embodiment] [0034] The embodiments of the present invention will be described in detail with reference to the accompanying drawings, wherein the same reference numerals refer to the same or similar elements throughout. The words in the embodiments are merely used to describe certain specific embodiments of the invention and are not intended to limit the invention. In addition, embodiments of the invention may include several novel features, which are not a single feature, and may be used to achieve the desired. The embodiments described herein make it easier for the user to receive optical coherence tomography screening for early detection and/or treatment of various diseases, ailments or symptoms (con (jiti〇n), such as the macula Pathology (maculopathy) or glaucoma, etc. [0035] The term "optical tonal tomography" generally refers to an interferometric technique used to image a sample, and in some cases, the image may have a micron-scale lateral resolution. Non-invasive optical tomography imaging techniques are used in ophthalmology to provide cross-sectional images of the eye, especially the posterior side of the eye, although the above techniques can also be used to image samples or tissues in other areas of the user's body. [0036] In general, 'optical coherence tomography uses an interferometer. Light from a source (such as a broadband light source) is split (for example, split using a beamsplitter)' and along the sampling arm (samplearm) (usually containing samples) and a reference arm (usually containing a mirror) to travel. The light from the sample arm is reflected by the sample. The light is also reflected by the mirror in the reference arm. (The light from the sampling arm and the reference arm is recombined, for example using a beam splitter.) The current line is at the distance of the sample arm. The distance traveled within the reference arm is the same; the optical interference (〇pticalinterference) occurs during the length of 201014571 degrees (coherencelength) and affects the intensity of the recombined light. The intensity of the combined reflected light varies depending on the sample characteristics. The measured reflectance intensity change is an indicator of the physical feature of the sample being tested. [0037] For example, in the application of time domain optical coherence tomography (time_d〇main 〇CT), The length of the reference arm can be varied (e.g., by moving one or more reference mirrors). The reflectance observed when the reference arm distance changes represents the sample characteristics at different depths of the sample. (In some embodiments, Change the length of the sampling arm to replace or add the length of the reference '.) in the frequency domain optical coherence tomography 〇ct) The distance of the reference arm can be fixed so that the reflectivity can be measured at different frequencies. For example, the frequency of the light emitted from a light source can span a range of frequencies or pass a grating. A dispersive element is scanned, and a detector array can be used to distinguish and detect different wavelengths. Fourier analysis can convert frequency-dependent reflectivity characteristics into distance-dependent The reflectivity of the 'reflects' shows the sample characteristics at different sample depths. In some embodiments, the optical coherence tomography scan may reveal other information or materials other than nonmydnatic color fUndus imaging. [0038] The term "A-scan" refers to the relative relationship between light reflectivity and different sample depths. The term "B-scan" as used herein refers to It is a cross-sectional view of a tissue formed by combining a plurality of a-scans. In the case of ophthalmology, the light reflected by the eye tissue is converted into an electrical signal and can be used to provide information about the tissue structure of the tissue and to show a cross-sectional view of the eye. For example, in the case of ophthalmology, A-scan and 3-scan can be used to differentiate normal or abnormal eye tissue, or to measure the thickness of the 1K tissue layer of the eye. [0039] In the ophthalmology example of $, the -A scan can generally include data from fine (na (4) to retina). In some miscellaneous tau, _transfusion can be included by the middle of the eye - the middle edge To the side edge and the cross-sectional data from the cornea to the retina. In some cases in 201014571...B-scan can include cross-sectional data from the top-edge of the eye to the material and from the cornea to the retina. Stereo (3D-OCT ) can be formed by combining multiple B-scans. ah layer scanning [0040] The "manufacturer" or "patient" or "object" made here is alternated, and the above is based on humans, whether it is in the doctor's = and For other mammals.

[0041] As used herein, "eye scan", "scanning of the eye" or the eye" are widely used to make each other f (4) _, Wei Changdai _ any part or 疋 substantially all measurements 'including but not limited to The retina, the eye lens (-), the iris, the optic nerve, or any other group associated with the eye are nerves. [0042] "RiskasSessment" and "diagQ〇sis" can be used interchangeably in the specification, although these terms have different meanings. "Risk Assessment" - The term usually refers to the probability, the number (mimbei·), the score (score), the grade (if any) and the estimate of the existence - or multiple *mness, disease, illness, etc. Estimate ) and so on. The term "diagnosis" generally refers to decisions made by examining and/or testing the characteristics or circumstances of a discomfort, condition, diseased condition, and the like. [0043] A variety of methods, systems, and devices are available for generating and applying optical coherence tomography image data to perform accurate measurement of retinal tissue to detect a disease feature, and based on optical coherence tomography imaging techniques The resulting data yields a risk assessment and/or diagnosis. In some embodiments, the methods, systems, and devices can utilize a statistical analysis of the detected symptoms obtained by optical coherence tomography imaging techniques. These methods, systems, and devices can be used for disease screening. Referring to FIG. 1, a block diagram depicting an embodiment of an optical coherence tomography system is illustrated. In one embodiment, the computer system 104 is connected to a round device (2), a communication medium (c〇mmunicati〇n medium) 108, and a user card reading system (user). Cardreacjer SyStem) u2. The media 108 can cause the electrical system i〇4 to communicate with other remote systems (rem〇teSyStem). The computer system 104 can be electrically connected to the main body (mainb〇dy) 1〇6, which is adjacent to the user 114 or bears against the eyes of the user. In the example shown in this figure, the body 106 is a binocular system (eg, two eyepieces (ocu(8) or two optical paths (〇pticalpath) that provide two different fields of view for the two eyes, respectively. ), etc. 'to scan both eyes without repositioning the position of the eyepiece relative to the patient's head, thereby reducing the time to scan a patient. In some embodiments, a scanner is used (eg A galvanometer provides an interlace 〇f measurement for both eyes to simultaneously scan both eyes. Other embodiments are also possible, for example, a binocular system with two optical paths respectively corresponding to both eyes. Or a binocular system can be used to continuously scan the eye, that is, scan one eye first, and then scan the second eye. In some embodiments, continuous scanning of both eyes includes scanning a first eye. a portion, a first portion of the second eye, a second portion of the first eye, etc. Alternatively, the body 106 can comprise a single eye system having a single optical path corresponding to one eye (monocularsystem) or a monocular system for performing an eye scan. ' [45] Referring to Figure 1, the user 114 can hold the handle 118 and position (e.g., up or down) the subject 106. The body 1〇6 is at least partially supported and connected to a gravity arm 116, and the system 100 does not have a smart device. In some parts, the earpiece is squatted. _ causes a positioning error. When the main body 106 is in this position, the distance between the outermost lens (the lens closest to the user) and the user's eyes can be between 1 〇 to coffee or 5 dirty to 25 mm, or between 5 匪 and 1 (). Mirror __ close contact of the user's eyes will increase the tightness of the system and reduce the patient's eye (eg, orbital rim) to the subject Positional variability at 106 o'clock (8) variability, and increases the angle of view of the optical coherence tomography device when imaged via an unilated pupil. 201014571 • [0046] Thus, the body 106 may also include an eyecup 120 (such as a disposable eyepiece cup (dis A posable eyecups)) for contacting a user's eye socket to substantially block ambient light and/or at least partially support the body 1〇6 on the eye socket of the user 114. The eyepiece cup 120 has a center Opening (such as an aperture) to allow light from a source in the instrument to pass through to the eye. The eyepiece cup 120 can be made of paper, cardboard, knee, enamel, metal, latex or Made by a combination of them. The eyepiece cup 120 can be a tubular, conical or cup-shaped elastic or semi-rigid structure having openings on both sides. Other materials, shapes and designs are also available. In some embodiments, the eyepiece cup 120 can be made of latex that conforms to the periphery of the eyepiece portion of the body ι6 _. After the eye scan is complete, the eyepiece cup 12 can be detached from the body 106 and a new eyepiece cup 120 can be engaged for a new user to ensure hygiene and/or to avoid disease transmission. The eyepiece cup i2〇 can be transparent, translucent or opaque, even if the opaque eyepiece cup provides the advantage of blocking ambient light in a bright environment. The body 106 can include one or more eyepieces, an interferometer, one or more target displays, a detector, and/or a pair of alignment systems. The optical coherence tomography system can include a time domain optical coherence tomography system and/or a spectral domain or a frequency domain optical coherence tomography system. Thus, in a portion of the Q embodiment, body 1 〇 6 includes a spectrometer (e.g., a grating) and a detector array. In some embodiments, the body 1-6 may include a signal processing component (eg, electronic device (electr〇nics)). Other types of optical coherence tomography systems can also be used. β [_8] Figure 2 shows a diagram illustrating an optical coherence tomography system. The light 15 〇 is output by a light source 155. Light source 155 can include a wide band light source, such as a super high brightness diode (superimeter), which can change frequency over time as a function of time. The wire 15 can contain collimated light. In one embodiment, the light 15 from the source 155 is collimated by a collimating lens. In another embodiment, the light is split at the split mirror 160. The spectroscopes described herein may include, but are not limited to, a polarization-based spectroscope, a temporally-based spectroscope, a 50/50 spectroscope, and/or the like. Device and configuration. A portion of the light travels along a sampling arm toward a sample, such as user 114's eye 165. Another portion of the light travels along the reference arm toward a reference mirror 170. The light reflected by the sample and the reference mirror 170 is combined at the beam splitter 160 and is composed of a one-dimensional photodetector or a two-dimensional detector array, such as a charge-coupled device (CCD). ) or a complementary gold semiconductor (complementaiy metal_oxide_semiconductor, CMOS) 'sensing. A two-dimensional predictive array can be included in an all-% optical coherence tomography instrument that collects information faster than the ® form of a photodetector. In time domain optical coherence tomography, the length of the reference arm (which may be determined to some extent by the position of the reference mirror 170) may change over time. [0049] Whether interference between the light reflected by the sample and the light reflected by the one or more reference mirrors depends on the length of the reference arm (compared to the length of the sampling arm) and the fresh light emitted by the light source . High contrast light interference occurs between optical distances where the light travels close (e.g., the gap is less than - coherence length). The length of _ is determined by the bandwidth of the light source. Broadband sources correspond to smaller coherence lengths. [0050] In Time Domain Optical Coherence Tomography - When the relative lengths of the reference arm and the sampling arm change over time, the intensity of the output ray can be analyzed as a function of time. The light signal from the side is caused by the interference of lightray scattered from the sample with light reflected from one or more reference mirrors. However, when the sampling arm is substantially equal to the length of the reference arm (for example, in some cases, it is less than a coherence length), the interference is generated. Thus the light from the reference arm will interfere with the light reflected from the sample nanwrange of depths. When the reference arm (or the sampling arm) is changed, the depth of the money can be recorded on the axis, ah, and the reflected light is reflected in the sample. The sample of scattered light scatters the light that interferes with the disc reference arm to thereby generate an interfering signal (five). Using a source with a short coherence length can increase the resolution (e.g., 1-10 microns) because a shorter coherence length produces a shallower depth range that is measured at a single instant in time. [0051] In many embodiments of frequency domain optical coherence tomography, the reference arm and the sampling arm are fixed. Light from a wide band source and containing a plurality of wavelengths is reflected from the sample and interferes with light reflected by one or more reference mirrors. The optical spectrum of the reflected signal is available. For example, light can be input to a spectrograph or a spectrograph comprising, for example, a grating and a detector array to detect the intensity of light at different frequencies. ❹

[0052] For example, performing Fourier analysis by a processor may convert data corresponding to a plurality of frequencies into data corresponding to a plurality of locations within the sample. As a result, data from multiple sample ice levels can be collected simultaneously without the need to scan the reference arm (or sampling arm). Further details on frequency-domain optical coherence tomography are described in Vakhtin et al. (Applied Optics, Vol. 42, No. 34, pp. 6953.6958, by Vakhtin AB, Kane DJ, Wood WR,

Peterson KA et al. co-authored "c〇mm〇n_path interfen" metCT 骱frequency_domain optical coherence tomography, ''a text). [0053] Other methods of performing optical coherence tomography are also possible. For example, Part of the frequency domain optical turn-off scanning is performed, and the frequency of the light from the light-emitting (four) changes with time. Therefore, the difference between the light intensity of a time function and the light is not the same. Related. When the system-spectrum time-varying light source (a secret y tune-varying light眶ce), a weapon can measure the light of a time function = 'interference signal ray spectrum. As mentioned before, the spectrum can be used Fourier transform. A wide variety of other techniques is also possible. The configuration of the main body 1G6, which includes - optical coherence faults. It can also include other optical _ tomographic systems and / or alignment systems to replace or add To the system shown in Fig. 3, as shown, the main body includes an eyepiece 203, and each eyepiece is used to receive a user 114. In the embodiment, the main body 1 () 6 includes only one connection. Mirror 2 〇 3. ' 13 201014571 [0055] Figure 3A shows a representative embodiment of an optical coherence tomography system. Light from a source 240 can be along, for example, one or more beam deflectors 280 A path transfer of vertical and/or horizontal modulation. A galvanometer can be used to achieve the above objectives. The galvanometer can control the horizontal and/or vertical position of a light beam from source 240 to thereby form A plurality of A-scans (and thus one or more B-scans and/or a stereo-optical tomographic scan). [0056] Light from source 240 is split at beam splitter 245. In some embodiments, the beam splitter 245 can be replaced with a high frequency switch, such as a galvanometer, which directs approximately 100% of the light to mirror 250a in approximately one 1/2 cycle period, Light of approximately ι〇〇〇/〇 is then directed to the lens hand 250b over the remaining period of time. The light source 240 can include a wide band light source, such as a superluminescent light-emitting diode. The light split at the beam splitter 245 is then split again at the beam splitter 285a or 285b to form a reference arm and a sampling arm. A first portion of the light splitting at the beam splitter 285a or 285b is referenced by a reference mirror 273a or 273b. The reference mirror 270a or 270b and the reference mirror 265a or 265b reflect. A second portion of the light splitting at the beamsplitters 285a and 285b is reflected by the mirror 250a or 250b, the mirror 255a or 255b, and the mirror 260a or 260b. Mirrors 255a or 255b, and mirrors 250a and 250b are coupled to a Z-offset adjustment stage 290b. Different parts of the eye can be imaged by moving the position of the adjustment platform 290a or 290b. Thus, the adjustment platform 290a or 290b can adjust the optical length between the source 240 and a portion of the sample and between the optical length of the light source 24 to the reference mirror 27A or 270b and/or the reference mirror 273a or 273b. difference. This difference can be small, for example less than a coherent length, to thereby facilitate the occurrence of optical interference. In some embodiments, the position of one or more reference mirrors (e.g., reference mirror 270a or 270b and reference mirror 273a or 273b) is movable and may be added to or substituted for a movable adjustment platform. Therefore, the length of the reference arm and/or the sampling arm is adjustable. The position of the adjustment platform 290a and/or 290b can be determined in more detail as follows based on the signal from the device. [0057] Light reflected by the mirror 260a or 260b is combined with light from the display 2i5a or 215b 201014571 at the beam splitter 230a or 230b. Displays 215a and 215b may include one or more light sources, such as in an emissive display, such as a matrix of light emitting diodes (LEDs). Other types of displays can also be used. The display can display a variety of shapes and shapes, including a ribbon and/or one or more dots. A portion of the optical path from light source 240 to the eye can be coaxial with a portion of the path from display 215a and 215b to the eye. These parts can be extended through the eyepieces. Thus, the light beam from source 240 will be coaxial with the beams from displays 215a and 215b so that the eye can be positioned and aligned using the display relative to the eyepiece. [0058] As described in more detail below, for example, user 114 may use images from the display to adjust the pupil distance, IP distance). In various embodiments, for example, the proper alignment of the two images presented by the display may indicate that the pupil distance has been properly adjusted. Thus, one or more adjustment controls 235 can be used to adjust the distance between displays 215a and 215b and/or the distance between eyepieces 203. Adjustment controller 235 can be placed on the side of body 106 or elsewhere. In some embodiments, the adjustment controller 235 can include a handle on the body 106, as shown in Figure 3B. In this embodiment, the rotation adjustment controller 235 can increase or decrease the pupil distance. [0059] The combined light (which is reflected by mirror 260a or 260b and from display Q 215a or 215b) is an adjustable electro-optical device that may carry (in (7) with) optical element 2〇5 ( Adjustable powered optics) (eg lens) 21 〇 Focusing. The adjustable optical device 210 can include a zoom lens or an iens system that can have, for example, an adjustable focal length and/or power. The adjustable optical device 21 can include or be part of an auto-focus system or can be manually adjusted. The adjustable optical device 210 can provide optical correction for situations where correction is required (e.g., the user removes the glasses while testing). The position of the electro-optical device '210 can be determined based on signals obtained by the devices described in more detail below. The focused light then travels toward a user's eye through an eyepiece 15 201014571 window (eyepieceWind0ws) or lens (optical element 2〇5) located at the proximal end of the eyepiece 2〇3. In the case of including a lens (optical element 2〇5), this lens (optical element 205) can cause light to be focused within the eye. [0060] This guide eye (4) light can be scattered by the _ or features of its towel. A portion of this scattered light may be directed back into the eyepiece. The lens (optical element 2〇5) can thus receive light 207 reflected by the user's eye, which travels through the electro-optical device 210' from the beam splitter 230a or 230b towards the beam splitter 22A or 220b, the beam splitter 220a or 220b reflects the light toward the beam splitter (or mirror) 295a or 29 north at 29 or 295b, the light reflected by the sample and the reference arm (between the beam splitter or the north and the beam splitter 295a or 295b) The path of the reference lens 273a or 27 and 27 plus or 270b) causes interference (thus, the sampling arm includes an optical path between the beam splitter 2 or 28% © and the beam splitter 295a or 295b, It includes a mirror 25〇a or 25〇b and 255a or 255b and a sample or eye ^) then the light is reflected by the mirror 225a or 225b towards the switch 275. In some embodiments, the switch 275 includes a switchable deflector (switchable) A deflector can switch the optical path to the first or second eye to collect data from the individual eye to be sent to the data acquisition device (eg, also aCqUis) device 202. The switch can include a low frequency switcher ( L〇w_丘eqUenCy sw^ch ), so that all data to be collected from one eye is obtained before the other eye collects the data. Alternatively, the switch may include a high frequency switch that can be interleaved to collect from each eye. Information. [0061] Such an instrument can be configured in different ways. For example, each eye can use a common reference path. In some embodiments, the reference arm includes one or more movable paths. The mirror adjusts the optical path length difference between the reference arm and the sampling arm. In other embodiments, the components can be added, removed, or repositioned. Other techniques can be used. [0062] For example, although not shown Polarizers and polarized beamsplitters can be used to control the propagation of light through the optical path in the optical system (pr〇pagati〇n). Other variations are also possible. Other designs can also be used. 16 201014571 • [(8)63 In some embodiments, an A-scan can be formed in the time domain. In these cases, the 'Z-axis offset adjustment platform and the corresponding mirror 250a or 250b and mirror 255a 255b • The position can be changed over time. Alternatively, the reference mirrors 270a and 270b and the reference mirrors 273a and 273b or other mirrors in the reference arm or sampling arm can be varied. The combined light associated with the position of each mirror can be analyzed to determine The characteristic of one eye, which is a function of depth. In other embodiments, an A-scan can be formed in the frequency domain. In these cases, the frequency of the combined ray can be analyzed to determine the characteristics of an eye. , which is a function of depth. In addition, one or more galvanometers can control the level and/or vertical position of the A-scan. Thus, multiple A-scans can be obtained to form a B-scan and/or a stereo optical coherence tomography. φ [0064] The light output from the structure (switch 275) can be input to a data acquisition device 202, which can include, for example, a spectrometer or a light meter. A grating can be in the body 106. The data acquisition device 2〇2 is coupled to a computer system 1〇4 which can present to the user 114 an output based on the scan results. The output device can include a monitor screen for displaying the output therein. The output device can include a printer to print the output. The wheeling device can be used to store data in a portable medium, such as a compact disc or a universal serial bus (USB) driver (USB) or a specific Custom portable data storage device 〇® '5] In some embodiments, the computer system 104 analyzes the data received by the data acquisition device 202 to determine one or more adjustment platforms 29 amp &amp; And/or 29〇b, and/or one or more movable components, and/or electro-optical devices 21〇 need to be adjusted. In one case, an A-scan is analyzed to determine the location of the view medium (e.g., approximate location) so that the instrument can obtain data on the view medium. In some embodiments, each-A scan includes a plurality of light intensity values, each light intensity value being a different depth from the sample application - in some embodiments 'can be adjusted by varying the Z-axis adjustment platform 290a or 290b Scan with (4) A. The same 'A scan contains 2 pastes to flatten the 'reverse rails' obtained from different locations. Recording _ difficult eye _ no partial reflection of the new home, so can be determined by "flattening which depth provides a reflection intensity to determine a position of the adjustment platform 290a or 17 201014571 290b to effectively image the retina. In some embodiments, the Z-axis adjustment platform can be varied and the intensity values can be monitored. An extended peak intensities at the locations of the several Z-axis adjustment platforms can correspond to the retina. Many different ways and values can be monitored. The position of the retina is determined. For example, multiple A-scans can be obtained at different depths and the integrated intensity of each scan can be obtained and compared to determine which depth provides a peak intensity. In some embodiments, the intensity values in an a scan can be compared to other values in the A-scan and/or a gantry. The intensity values corresponding to the preferred locations can be higher than a predetermined or relative and/or Unlike other audibility values (eg, a certain number greater than the standard deviation), many different methods can be used. [0066] After the positions of the entire platform 29〇a and 290b, subsequent image analysis can be performed to calculate the proportion of the user's head, eyes or retina relative to the vibration or movement of the light source 24Q. For example, a closed loop feedback system (dosed loop - k system) is used to provide a more stable signal when the above actions exist. The optical coherence tomography signal can be monitored and provided to, for example, one or more active platforms (translation In order to compensate for the above vibrations and movements, in some embodiments, the 'subsequent image analysis may be based on changes in the initial image and/or gamma image characteristics. For example, 'image analysis may determine the brightest pixel in the -A scan ( Pixd) has moved the second transfer from a previous scan. In this case, the adjustment flat 29Ga &amp; 29Gb can be moved based on the above analysis. Other methods can also be used. [0067] In some cases, optical coherence tomography signals are used. To adjust the electro-optical device 21G to provide increased or improved focus, for example, when the patient needs refractive correction (refractiveC0ITecti0n). For example, many users/patients may Wearing glasses, and may not wear any glasses during the test. Electric optics 21 () can be adjusted based on the reflection signal to determine which correction to add to improve the signal is improved. In some embodiments, the 'analyze a plurality of eight scans to determine the position of the electro-optical device (10) in the embodiment' is determined after the position of the adjustment platform 29A or (10) is determined. At multiple positions of the electro-optical device 21G Each position can be obtained from 18 201014571 to one or more A-scans, one or more B-scans, or a stereo optical coherence tomography. These scans can be analyzed to assess, for example, image quality. The position of the electro-optical device 210 can be selected based on these image quality measures. [0068] Image quality measurements may include a noise measure. The noise measurement can be estimated based on the distribution of different intensity levels of the reflected light in the scan. For example, a lower signal may be related to noise. Conversely, the highest signal may be related to a saturated signal. A noise measurement can be compared to a saturation measurement as a noise ratio or a variation thereof. The lowest reflectivity measured (refer to a low or low signal value) can also be considered. In some embodiments, the determination of the position of the adjustment platform 290a and/or 290b and/or the electro-optical device 210 is based on a signal-to-noise measurement, a signal strength measurement, and a noise. Measurement, a saturation measurement, and a low signal measurement. Different combinations of the above parameters can also be used. It is also possible to use values obtained by combining more than one position or scanning parameters. Other parameters and other image quality assessments can also be used. [0069] In an embodiment, a noise value is estimated as a reflected light value, wherein about 75% of the measured reflected light is lower than the noise value, and about 25 The measured reflected light of % is higher than this noise value. The saturation value is estimated as a reflected light value, wherein about 99% of the measured reflected light is below the saturation value, and about 1% of the measured reflected light is above the saturated value. A middle value is defined as the noise value and the mean value of the saturation value. An intensity ratio is defined as the difference between the saturated value and the low signal value, divided by the low signal value, and multiplied by 100. A tissue signal ratio is defined as the number of reflected ray values between the intermediate value and the saturation value divided by the number of reflected ray values between the noise value and the saturation value. A quality value is defined as the intensity ratio multiplied by the tissue signal ratio. Further details are described, for example, in the Journal of Br. J. Ophthalmol, 2006, Vol. 90, pp. 186-190, by Stein DM^ Ishikawa H, Hariprasad R, Wollstein Q Noecker RJ, Fujimoto JQ Schuman JS. A new quality assessment parameter for optical coherence tomography" in article 19 201014571. A number of other different methods can also be used to obtain a quality factor (figure〇fmerit) for measuring the results and adjusting the instrument accordingly. .

[〇〇70] Among the adjustments of the adjustable electro-optic optical device 21〇, in the partial implementation, in the example, a plurality of positions are tested. For example, the electro-optical device can be moved toward the eye with a defined increment (__) for each scan or multiple scans. Alternatively, these locations may depend on previously determined image quality measurements. For example, assuming that the electro-optic device 210 adds an image quality measurement to a first movement of the eye, and a second movement toward the eye-reduced image reduces an image quality measurement, then the third movement can be away from the eye. Therefore, the optical power setting (〇pticalp〇Wersetting) can improve and/or maintain the improved signal. In some embodiments, the optical power setting can be related to optical correction and can increase the focus of the beam in the eye, e.g., on the screen. As described above, many embodiments employ a configuration in which a pair of eyepieces are employed. Since a user's eyes may be of different sizes and the viewing network is at different depths, these adjustments can be applied to each eye, and in some embodiments, the Z-axis can be used to adjust the platform. Similarly, the different eyes of the user may have different optical correction processing methods (different prescripti()n Qptieal. A number of configurations may be employed to meet the above requirements. For example, the eye can be performed and the measurement is completed and / or after the adjustment, then perform and complete the other eye. Or ^ can be at the same time age or staggered _ amount and whole. Other Xu recorded financial style is also OK. © [0072] Figure 4 shows a spectrometer 4 〇〇 The figure can be used as a data acquisition device 2G2 of a frequency domain optical coherence tomography system. The light 4〇5 input to the spectrometer is collected by the collecting lens 410. The collected light is then projected through a slit 415. The collimated light is then collimated by a collimating lens 420. The collimated light is dispersed into a different spectral component by a grating 425. The grating 425 can have optical power to focus the spectral distribution on an image plane ( Imageplane). It is worth noting that _, other separation components, such as a prjsm, can also be used to disperse light. The light is then directed by a focusing lens 430 to a 20 201014571 system, so that it depends on the spectral elements from each of the different optical fibers. [0073] Many different optical coherence tomography designs are also For example, the frequency may vary over time. The reference arm and the sampling arm may overlap. In some embodiments, a reference arm is different from a sampling arm, whereas in other embodiments, the reference arm and the sampling arm For sharing, please refer to, for example, Applied Optics, No. 42, 2003, 34th edition, 6953-6958 I. ^ Vakhtin AB, Kane DJ, Wood WR, Peterson KA. Co-authored "C〇mm〇n-path interferometer· for freqUency_d〇main 〇ptical coherencetomography. The configuration of the optical coherence tomography should not be limited to that described herein. Other variations are also possible. [0074] Among some of the embodiments shown in FIG. 5, The main body 1 6 includes only a single display 215. The light from the display 215 is split at a circle (x_prism) 5〇5. It is worth noting that other optical devices (〇pticaldeyice) can be used. The source light is split into a plurality of light rays. The split light is reflected at the mirror 51 as or 51% and directed toward the user 114. [0075] When - or a plurality of galvanometers are moved from the light source 24 The light, when imaging an area of the tissue, can be used to guide the user to fixate a display target. In some embodiments, when an area of tissue is imaged, the display object moves within the field of view of the user. For example, in the ® 6A, the display can be moved horizontally (for example, on the medial side), so that a patient can be viewed from left to right or from right to left. At the same time, a lead scanner (e.g., a galvanometer) causes the vertical position of the sample under scanning (e.g., in the up and down direction) to change over time. Figure 6A shows that only the eye is guided to move in the horizontal direction 605. Due to the vertical scanner, the scanning trajectory 61 covers most of the eye 600. Scanning in horizontal and vertical directions produces stereoscopic optical tomosynthesis. In some embodiments, continuous and/or regularly patterned A-scans are combined to form a complete scan, such as a B-scan or a stereo optical tonal tomography. In other embodiments, a non-continuous and/or random A-scan is combined to form a full scan. In contrast to having the user 保持4 keep their eyes gazing at a fixed target configured system, the system configured to move 21 201014571 user m to move their eyes during a scan may include fewer scanners . For example, in contrast to a system in which both the ship and the horizontal scanner are combined, the user m can move his eyes horizontally to thereby eliminate the need for a horizontal scanner. [0076] Among other embodiments, a rider scanner (e.g., a straight line and a horizontal scanner) can be made. The design, performance, and/or specifications of these scanners are not required. For example, 'these scanners' can be faster and/or have higher resolution than others. More specifically, the - Straight Scanner is available in a horizontal scanner for faster scanning, or vice versa. In some exemplary embodiments, scanners having different velocities, such as galvanometers, may be used to continuously scan in the wrong direction and only occasionally (嶋 ❹ in incrementally in the horizontal direction (or vice versa) In some embodiments, for example, the speed of the scanner may be 1/2 to 另一 of the other portion, but values outside the range are feasible. For example, the stereoscopic, tuned sweeping image may not have as many pixels as the other side ===:= in the direction (for example, the horizontal direction). In some embodiments, for example: The image of the singer can be _χ 512, the other is as large as the material can be resolved or the galvanometer may have compared with the other scanner - the smaller the size of the two-in-one scanner compared to the other Among the examples where the scanner has a lower = degree or a lower resolution, the field speed galvanometer can be used. Therefore, the scanners or ❹ of the two neighbors can be _ type _ level L Chi Jia ((4) expensive) and - Miscellaneous energy 姊 poor (more convenient. Its device or galvanometer can Reduce the overall flow meter of the instrument. In some embodiments: == indicates =, the case mentions - or multiple inspections. J f used to replace the flow detection with a different kind of scanner [〇〇"] Fig. 6B shows an example of the brightness of an A-scan, and #-赫里七$^ contains a shouting intensity (a function of the depth of the position including the octopus and the water-straight position. Therefore, -A;^ Corresponding to different front and rear lateral fineness values. Multiple A-scan formations—= 22 201014571 - Figure 6C shows a B-scan in which the largest part of the bright signal corresponds to the retinal tissue and the sub-retinal ascending region (elevated) Regions correspond to lesions in the eye «diseased tissue. [0078] Referring to FIG. 7A', an enlarged view is taken to depict an embodiment of the body 1"6. The body 106 is provided with a handle 118 for The eyepiece cup is adjusted to conform to the user's interpupillary distance. In the illustrated embodiment, the body 1〇6 includes a left eyepiece cup 712 and a right eyepiece cup 714', wherein the pupil distance adjusting device is mutually 718 are connected to each other. The adjustment device 718 is connected to the handle 118, wherein the handle 118 is used for the user to buckle the handle 118 to adjust the distance between the left and right eyepiece cups 712 and 714, φ to match the pupil distance between the user's eyes or [0079] Referring to FIG. 7A, the user can rotate, turn, or twist the handle usus to adjust the distance between the left and right eyepiece cups 712 and 714 to lie with the user's eyes. The hole distances match or substantially conform to. Alternatively, the handle 118 can be used to move from side to side for the user to adjust the distance between the left and right eyepiece cups 712 and 714. Additionally, the handle 118 can be moved back and forth for the user to adjust the distance between the left and right eyepiece cups 712 and 714. Additionally, the handle 118 can be moved up and down so that the user can adjust the distance between the left and right eyepiece cups 712 and 714. In another embodiment, the distance between the left and right eyepiece cups 712 and 714 can be adjusted and/or controlled via a motor activated by the user. Alternatively, the motor can be controlled by computer system 104 to semi-automatically clamp left and right eyepiece cups 712 and 714' to match the pupil distance between the user's eyes. In these cases, a system described herein can include an eye tracking device (eye dev1Ce). In other embodiments, a combination of the foregoing items may be utilized to adjust the distance between the left and right eyepiece cups 712 and 714 to match or substantially conform to the pupil distance between the user's eyes. [0080] A user 114 can adjust the pupil distance based on the user viewing one or more of the one or more displays 215 on the flxati〇n target. For example, it can be sighed, the display 215 and the gaze target's. Therefore, when the pupil distance is appropriate for the user 114, the user will see two aligned images (stain &amp; ), which can form a single, complete image of 23 201014571. The user 114 can adjust (e.g., rotate) the adjustment controller 235 to change the pupil distance based on the image of the gaze target, as shown in Figure 7A. Figures 7B through 7F illustrate an embodiment of the gaze target viewed by the viewer in a variety of situations; however, other gaze targets are also possible, including but not limited to a box shape (b〇x Configuration). Fig. 7B shows a u-shaped target 715a on the display 215a corresponding to the left eye. Fig. 7C shows an inverted u-type gaze on the display 215b corresponding to the right eye. [0081] When the pupil distance has been properly adjusted, the bottom and upper images (the gaze targets 7i5a and 715b) are aligned, as shown in Fig. 7D. 'To form a complete H-shaped gaze target 715. When the pupil distance is too narrow, the gaze target &amp; 7 corresponding to the display 2 of the left eye is displayed to shift to the right, and the 715 of the gaze target 215b corresponding to the right eye is displaced to the left, and the user will see the figure Image shown in 7E. Conversely, when the pupil distance is too wide, the gaze target 715a on the display 215a corresponding to the left eye is displayed to shift to the left, and the gaze target 715b on the display 215b corresponding to the right eye is displayed to be displaced to the right, and the user will see as shown in the figure. Image shown in 7F. Therefore, the pupil distance can be adjusted based on the above image. [0082] Especially in @7D, the shape of the alignment image (the π of the gaze target) is - Η shape. Therefore, when the pupil distance is correctly adjusted, the gaze targets on the left and right sides overlap to form a Η shape. Other alignment images (eyes 715) are also available. _ _3] An embodiment of the computer system, system 1 〇 4, is shown with reference to Fig. 8 '(4). In the illustrated embodiment, the computer system 104 can include a scan control and analysis module (_c〇ntr〇1 - analyse modde) 824 for controlling the scanning program executed by the main body 106 (s-mail operation) ). The computer system 104 can also include a gaze marker control system 822 for displaying a fixation marker that the user can see from the subject 1-6. In some embodiments, the gaze mark is shown as a scorpion, a point, a box, or other shape. The gaze mark can be moved horizontally, staggered, diagonally ((4) plus), - circularly, or in a combination of the above. The gaze marker can quickly change position when the eye changes itself to change position to reposition the beam on the retina. 24 201014571 • Computer system 104 may also include a focus acyust module 820 for automatically adjusting the focus lens in body 106, which will be discussed in detail later. Computer system 104 may also include a z positioning module 818 for automatically adjusting the Z-axis offset discussed herein. [0084] Referring to FIG. 8 'The computer system 1 〇 4 in the illustrated embodiment includes a disease risk assessment / diagnosis module 808 for accessing the disease for determining and assessing the disease. Information, data and algorithms for risk or likelihood, and/or a diagnosis based on data and/or measurements obtained by scanning the user's eyes. In one embodiment, the scan control and analysis module 824 is configured to compare the data received by the Q from the subject 106 with the data stored in the disease risk assessment/diagnosis module 808 to generate a user as described below. A risk assessment and/or diagnosis of a disease in the eye. The computer system 104 can also include an image/scan database for storing images and/or scan results of a plurality of users generated by the main body 106, and storing an individual associated with each image and/or scan. Some identifiers (yjjjque identifier). In some embodiments, the scan control and analysis module 824 compares the historical image and/or scan results of a particular user with the current image and/or scan results of the same user. To detect changes in the user's eyes. In some embodiments, the scan control and analysis module 824 uses the detected Q changes to assist in generating a risk assessment and/or diagnosis of a disease in the user's eye. [0085] In the illustrated embodiment shown in FIG. 8, computer system 110 may include a user/patient database 802 to access patient information, such as user name. , birthday, mailing address, residential address, office address, unique identification number, age, affiliated doctor, phone number, email address, social security code, race, gender, eating habits and related information, lifestyle And/or exercise habit information, corrective lens use, family health history, medical and eye history, preprocedures (priorprocedures) or other similar user information. The computer system 1〇4 can also include a physician referral database for accessing physician information such as physician name, physician training and/or expert/speciality, and medical 25 201014571 division Clinic address, physician phone number and/or email address, physician scheduling availability, physician rating or quality, physician's office time, or other physician information. [0086] Referring to FIG. 8 'computer system 104 may also be a user interface module 805 (which may include, without limitation, the following common input/output (I/O) devices). And interface) for audible verbal command, a voice recognition interface, a keyboard, a toggle, a joystick handle, a switch, a button, a visual display (visual display), touch screen display, etc. or combinations thereof communicate, indicate and/or interact with the user. In some embodiments, the user interface module 805 is used to direct and/or direct the user to use and/or locate the body 106 of the optical coherence tomography system 100. The computer system 1 4 can also include a reporting/output module 806 for generating, outputting, displaying, and/or printing a report (eg, Figures 11A and 11B), including disease risk assessment/diagnosis. Risk assessment and/or diagnosis generated by module 808. In other embodiments, the report includes at least one referral physician to contact the content of the risk assessment. [0087] Referring to FIG. 8, the computer system 1-4 may also include an authentication module 816 for use as an interface with the user card reading system 112, wherein a user may A user identification card is inserted into the user card reading system 112. In some embodiments, the authentication module 816 is configured to authenticate the user by reading the data of the identification card and compare the data stored in the user/patient database 802 and/or Or store information. In some embodiments, the authentication module 816 is for reading or obtaining the user's insurance information from the user identification card via the user card reading system 112. The authentication module 816 can be used to compare the user's insurance premium §fl with the data stored in the insurance database (insurance) 828 to determine whether the user's insurance is accepted or the user's insurance company. Will the cost of scanning the user's eyes be paid. In other embodiments, the authentication module communicates with a billing module 810 to send a message to the manufacturer and/or device manufacturer (4) such as __ The request for payment is performed on the patient's eyes - the cost of the scan. The card can activate a function of the machine or the user to perform a test, for example, to perform a test or receive the output from the machine. In the embodiment, the 'billing module 81' is used to communicate with the user interface module milk to request the side. All or part of the payment (e.g., a common burden (in some embodiments), in some embodiments, the billing module (10) is used to communicate with the maker picking system 112 to obtain the user's credit card, debit card, gift. The card information, or the deduction of the miscellaneous charge, or the billing module (10) is used to receive the user's payment by receiving the communication and/or control-interface device to receive the chip, the coin, and the other. Alternatively, the billing module 81() is used to communicate with the user via Bluetooth 8) or other protocols/channel protocols/channels (m〇wle(4) drink^(4) card (4) 'fresh address, disagreement The provider's line service account mobde network serviee ae_t) asks for a fee (such as the cellular carrier network) to receive payment from the user. _8] References® 8 'user cards can be used by insurers (5) to resist which ones have used this green. In the "Examples", you can scan the risk assessment and / directly print (on the surface of the card) or store (in the magnetic stripe) - the card inserted into the system = card The second will be returned to the user). The system can be used to store multiple scan results, winds, and/or σ ' and/or to clear previous traces, risk assessments, and/or reports prior to storing new information on the magnetic stripe. In some implementations, the calculation of the risk assessment is = performed (eg, scan control and analysis module 824). In some embodiments, the calculated risk assessment is communicated to a central device system (eg, a remote system (10)) at another location, which provides physicians, producers via a webpage. 'Silk. This central ship system (eg, remote system: patient or doctor enters its card card (CardC〇de)' to view the results stored in the centralized database. 27 201014571 [0089] The illustration in Figure 8 In an embodiment, the computer system 104 can include a network interface 812 and a firewall 814 to communicate with other remote systems 110 via a communication medium 108. Other remote systems 11 It may include, but is not limited to, a system for checking the status/accuracy of the optical coherence tomography system; a system for updating the disease risk assessment/diagnosis module (database) 808, underwriting Database 828, physician referral database 8.4 and/or scan control and analysis module 824. In some embodiments, computer system 1-4 can be used to communicate with a remote system 110. The subject 106 performs a preliminary and/or second risk assessment of the data obtained by the user's eye scan. [0090] Referring to Figure 8, the remote system 110 can be implemented remotely (in an immediate, delayed, and/or batch) Way) a wind Evaluating and/or diagnosing and transmitting a risk assessment, diagnosis, and/or reporting to the computer system 104 via a network or communication medium for output to the user using the output device ι 2 . In some embodiments, the output device 102 For displaying a risk assessment, diagnosis and/or report on a web page, which can be printed, emailed, transmitted and/or stored via the computer system 104. The remote system 110 can also be used to communicate via a network and/or The communication medium transmits a risk assessment, diagnosis and/or report to the user (or doctor)'s mobile phone, computer, email account, fax or other. [0091] Please refer to FIG. 9, which shows the use of optical coherence tomography system 1 The method disclosed is to self-administer an optical coherence tomography scan of the user's eye and to obtain a risk assessment or diagnosis of various diseases and conditions. The procedure begins at block 9.1, where the user approaches the optical coherence fault The system 100 is scanned and the system is started by, for example, pressing a button or typing in an activation code or an anonymous identification number. In other embodiments, in block 901, the user interface module 805 instructs the user to first insert an identification card or an anonymously encoded screening card into the user card reading system 112 to activate the system. In block 〇1 The system can also be activated when the user inserts his identification card into the user card reading system 112. Other ways of starting the system are also possible, including but not limited to 'a motion sensor (moti〇n sensor), one A weight sensor, a radio frequency identification (RFID) device, or other 28 201014571 actuators are used to describe the presence of the user. Alternatively, the optical tomography system 100 can activate the beta or the billing mode when the billing module sio 4 detects that the user puts the bills, coins, tokens, etc. into the receiving and receiving interface device. Group 81〇 communicates with a device, the device to obtain the user's credit card information, billing address or other 'or when the user's mobile network service account (such as the mobile phone operator network) asks for the fee The billing module 810 can also be used to activate the optical coherence tomography system trace. [0092] Referring to block 902 of FIG. 9 'user interface module 8〇5 for guiding the user to join the disposable eyepiece cup to the main body 106 Then, the main body 106 having the disposable eyepiece cup is placed near the user's eyes and/or the disposable eyepiece cup is supported by the user's eye socket. The user interface module instructs the user to buckle the handle 118 to adjust The distance between the left and right eyepiece cups 712 and 714 is matched to the user's pupil distance or substantially the same as the relationship of Figures 7A through 7F. After the user properly aligns and/or adjusts the distance between the body 106 and the pupil, the user inputs or instructs the user interface module 8〇5 to begin scanning. The scan control and analysis module 824 substantially limits the movement of the zero gravity arm or locks its position and/or the distance between the left and right eyepiece cups 712 and 714 to begin scanning. Referring to FIG. 9, in block 906, the x-axis positioning module 818 automatically adjusts the x-axis offset in the body 106 such that optical tonal tomography measurements can be obtained, for example, from tissue in the retina. Module 818 can identify and/or estimate the position of a portion of the sample (e.g., a portion of one eye of a user 114) and adjust the position of one or more optical elements based on the position. Those skilled in the art will appreciate the many ways in which this adjustment can be performed. For example, the 'sleeve positioning module 818 can include a motor, such as a piezoelectric motor, to longitudinally vary one or more reference mirrors such that the optics from the beam splitter to the retina The path length is approximately equal to (within the coherence length) the optical path in the reference arm. Such movement can cause light from the reference arm to interfere with light reflected by an intended portion of the sample, such as the retina. . In block 908, the illustrated method uses focus adjustment module 820 to perform focus adjustment. Cooked, the skilled artisan will also appreciate the different techniques used to perform the above described auto focus correction (autQ_foeus calibration). Block 910 illustrates an optional test performed by computer system 104 to determine the visual function of the user's eyes (visual ^ (10)) and/or acuity. In some embodiments, the visual acuity test is performed or combined with the fixation marker control system 822 and can simultaneously test both eyes or - sub-linings. As a result, the gaze mark appears to be the smallest, and then the size gradually becomes larger until the user indicates that the gaze mark is visible through the user interface module 8〇5. Based on the size of the gaze marker that the user can clearly see, the gaze marker control system 822 can estimate or determine or assess the user's vision (eg, 2〇/2〇, 2〇/4〇, etc.). Referring to Figure 9', in block 912, the user interface module 8〇5 instructs the user to follow the movement of the gaze marker seen by the user on the body 106. In one embodiment, the gaze mark control system 822 is a gaze mark used to display horizontal movement. In the partial embodiment, the horizontal movement of the gaze mark causes the scan control and analysis module 824 to scan the eye in a straight line when the eye moves horizontally, so that it is possible to obtain a two-dimensional, Volume or raster scan. Alternatively, the scan control and analysis module 824 and/or the gaze marker control system can cause the subjective marker or beam to jump or move to obtain measurements of different lateral positions on the eye. [0095] During scanning of the eye, the scan control and analysis module 824 can be used to detect in block 913 whether the position of the body 1〇6 relative to the user has been displaced. In one embodiment, the scan control and analysis module 824 can detect (in real time, substantially instantaneously or delay) based on the value that the scan control and analysis module 824 expects to receive during the scan process. Way) Whether a displacement is generated. For example, when the scan control and analysis module 824 scans the retina, the scan control and analysis module 824 is expected to be in the proximity of the optic nerve when the scanning procedure is performed (eg, based on the location of the gaze marker and/or the scanner) , state), detected a signal change. Alternatively, a line graph (n〇m〇gram) can be used to determine or generate a rhyme value or a pre-flight variable. If the neon does not have a consistent detection of the incarnation optic nerve - the expected signal change and/or no signal change is received, the scan control and analysis module 824 can be used to interpret the data as a user. Correctly pursue. Other features, such as the fovea of the retina, etc., can be used to determine whether the expected signal is observed. If sufficient improper follow-up is generated (eg, based on; threshold), the system (10) may require the user to re-watch for another scan (using the gaze flag control system 822). If the above-mentioned displacement detection procedure does not occur in an immediate or substantially instantaneous manner, then the system can be used to complete the scan, perform data analysis, and during the analysis, the system can be used during the scanning process. Produce - displacement. If the side-to-substance displacement, the user can accept the instruction (by using the user interface module 8〇5 visual, sound, or voice command (verbaling plus Λη)) to sit forward again to perform another time scanning. If the system measures a displacement of 2, 3 or more times, the system can be used to introduce the user to a general ophthalmologist. 〇 [〇〇96] At the end of a scan, the scan control and analysis module 824 can be used to generate a confidence value that represents the feasibility that the nomogram will be applied to the patient. For example, if a patient has a marginal county, his or her beliefs may be lower than a patient with a good gaze. [0097] In an immediate embodiment, the system can be used to perform a fast cross-correlation (cr〇ss_c〇1Teiati〇n) operation between adjacent A-scans or b-scans, with the green eye being slightly moved. In part of the remuneration, the former financial model can have the American National Standards Institute (ANSI) laser safety standard to avoid letting users stare at the same one when laser energy bombards the user's retina. position. Thus, in some embodiments, the system is provided with a feature of laser pause when the system is less than eye movement (e.g., the cross-correlation is above a particular threshold). In some embodiments, to speed up the process and provide real-time analysis in frequency domain optical coherence tomography, the signal data *T is analyzed prior to performing a fast fourier transform (FFT). Other techniques can be employed to determine that the user has certain eye movements. [0098] If the problem of gaze is not detected, the scan control and analysis module 824 completes the scan of the user's eyes, and stores the image and/or broadcast information in the image/scan database 826, and in block 915. The A-scan data is analyzed to generate/determine a risk assessment and/or diagnosis by reading the data and/or algorithms stored in the Disease Risk Assessment/Diagnostic Module (Database) 808 in block 916. . In some embodiments, the A-scan group 31 201014571 can be analyzed. At least one of the B-scanner portion or the full-touch stereo optical shutdown scan data.

[〇(8)9]_H_“Ship Map”—The term usually refers to predictive tools, algorithms, and/or datasets that generally provide a predictor of the taste of the leader. The nomogram can be derived, generated, calculated, or computed by some, for example, hundreds, thousands, or millions of users/patients presenting the same symptoms (normal or U disease). In some of the embodiments described herein, the nomogram compares the risk of having a disease based on physical characteristics. Therefore, in some cases, the list, _ can provide an individualized prediction of the risk level (risk suppression (4)) of a patient group with similar disease characteristics. In some embodiments, the nomogram can be used to provide a test or assessment based on a 0-100% scale. Alternatively, the nomogram used herein can provide an expected value, such as an expected eye thickness value at a particular location on the eye of 100 microns. [0100] In general, nomograms have been developed and validated among the broad patient population and are highly inductive (jjigjjygeneraiizabie), so the nomogram can provide objective, Evidence-based, personalized risk prediction or assessment. Therefore, the nomogram can be used as described here to authorize patients

(empower) and make them more aware of their disease. Furthermore, the nomogram used here can assist physicians in making clinical decisions (C1 jujcg) decision-making and provide consistent, standard, and reliable predictions. [0101] In block 917 of the illustrated method illustrated in FIG. 9, an eye health assessment or eye health rating report is generated for the user by reading a disease risk sweat/diagnosis module (database) 808. 10A and 10B are shown. In block 918, the physician referral repository 804' is read to generate a recommendation for when the user needs to be medically (e.g., within one to two weeks). The physician referral database 804 can also be read to generate and compile a list of physicians suitable for treating the patient. The physician referral list can be randomly generated or based on a referral fee paid by a physician or insurance company (referral 32 201014571 . fee Parent), or based on the location of the physician relative to the user or the office/home The address is selected, or based on the detected disease, or the severity of the disease (sev_) is selected, based on the location or proximity of the location, or based on the above group The person in block 919 reports to the user by using the report/output module 8〇6 and the wheeling device. In some real-side tissues, the report is based on the continuation of the gamma (4) library: in 'for subsequent analysis or for comparative analysis with future scans 〇 [0102] in partial implementation In the example, the body 106 is not supported by the user 114. For example, body 106 can be supported by a free-standing structure, as shown in Figure 10A. The user 114 can view it toward the eyepiece. The user 114 can sit on a seating apparatus, which can include a height-adjusting mechanism. The body 106 can be supported by a height-adjustable support. [0103] In some embodiments, as shown in FIGS. 10B to 1〇c, a tape (blood) is connected to the main camera 1〇6. The strap can be used to support the body 1〇6 in whole or in part, as shown in Figure i〇b. The band 1〇〇5 may not be included in some embodiments. The main body 1〇6 can be held by the user. In some embodiments, the body 106 can be supported on an eyewear frame. In some embodiments, all of the optical devices are housed in a body 106 that is directly or indirectly supported by the user 114. For example, the body 1〇6 in FIG. 1A may include an optical coherence tomography system, a pair of bit systems, and a data acquisition device. The data acquisition device can wirelessly transmit the data to a network or computer system, or can use a cable to transmit control signals. Figure 10C is similar to Figure 1 and is supported by a separate support structure (e.g., a zero gravity arm). In some embodiments, straps, belts, and other fasteners assist the body 1〇6 in aligning with one or both of the eyes of the user 114. [0104] In some embodiments In the case shown in FIG. 10D, the user wears an object 1010 connected to the eyepiece. A wearabie article can include a head 33 201014571 a head-mounted item, a hat or an item that can be placed on a user's head. As described above, in some embodiments, the body 106 is supported by a frame of glasses such as an eyeglass worn by a user. The wearable article 1010 can support all or part of the support body 106' and/or assist the body 106 with the user 114 in one or both of the eyes. [0105] Referring to Figures 11A and 11B, two exemplary embodiments of eye health ratings and eye health assessment reports are illustrated. Referring to FIG. 11A, the eye health rating report may include, without limitation, the number of various eye health categories (categ〇ry) of each eye of the user, including, but not limited to, macular health conditions, Optic nerve health, eye clarity, etc. The eye health rating report may also include at least one recommendation to seek medical advice or consult a physician at a particular time, and may provide at least one physician who can be contacted. The information used to generate the recommendation information and refer to the physician's list is stored in the physician referral database 804. Referring to Fig. 11B, the eye health assessment report may include a representative map of various eye health categories representing each eye of the user (gjapjjjcd represen sister i〇n). The report can be presented on an electronic display, printed on paper, printed on a card inserted by the user into the machine, electronically stored on the user's identification card, electronically mailed to the user, or presented in the above combination To the user. Referring to FIG. 12, another embodiment of an electronic brain system 104 coupled to a remote system 11 and a billing/insurance reporting and payment system 1201 is illustrated. The billing module 81 can be used to communicate with the billing/insurance reporting and payment system 1201 via the communication medium 108 to request or process an insurance claim for scanning the user's eyes. Based on communication with the billing/insurance report and payment system 1201, the billing module 81 can also be used to determine the amount that the user's insurance company can pay or cover, and/or to calculate or decide to share the fee with the consumer. The amount of the burden. In some embodiments, the user can interact with the user interface module 8〇5 to schedule an appointment with one of the recommended physicians, and/or to schedule a notification to a physician. (reminder) to the user. The computer system 1〇4 or a remote system 110 can be used to send the prompt to the user by means of email, text message, general mail, automatic telephone message, etc. Computing System [0107] In some embodiments, the above-described system, computer client (c〇mputerdient) and/or server are represented in the form of a computing system 13A shown in Figure 13, which is via one or Implementation of a computing system (which may be a fixed system or a mobile device) in which multiple networks 1310 communicate with one or more computing systems 13 and/or one or more data sources 1319 Example - block diagram. Computing system 13 (8) can be used to achieve one or more of the systems and methods described herein. Moreover, in one embodiment, the computing system 13 can handle the image slot. Although FIG. 13 illustrates an embodiment of the computing system 1300, it is contemplated that the functions and components provided in the components and modules of the computing system 13G() may be combined by fewer components and modules. Or can be further dispersed into other components and modules. _User/feeding device 桦细❹ [〇 just in the example, the system contains an image processing and analysis module (image pm ng and __ m〇dule) 13〇6, its implementation (ah. (4) The miscellaneous and neon cakes described herein. The miscellaneous and the readings are read as follows (eentralPrceeSSlM, CPU), in the calculation system system, in the calculation system, in the calculation of the system, The system and method may partially or fully include - or multiple components and/or modules. For example, == 35 201014571 so that it can be implemented in a server array. [0110] In general, the "mode" used herein The term "group" refers to a logical operation implemented in hardware or firmware, or a large number of software instructions that can have entry and exit points written by a programming language. For example, Java, C or C++, etc. A software module can be compiled and linked into an executable program, installed in a dynamic link library (either in a dynamic link library) or in a continuous translation language ( Interposed programming language) For example, BASIC, Perl, Lua, or Python. We will appreciate that the software module can be called out by other modules or by itself, and/or can be triggered (Evoked) to respond to the detected event (event ) or interrupt (intemipt). Software instructions can be embedded in the firmware, such as an erasable programmable read only memory (EPROM). Furthermore, we will be able to further understand the hard The body module may be composed of a connected logic unit, such as a gate and a flip-flop, and/or a programmable unit, such as a programmable gate array or The processor is composed of. The preferred embodiment of the module described herein is a software module, but can also be presented in a hardware or firmware manner. Generally, the module described herein refers to logic. A logical module 'which can be combined with other modules or cut into sub-modules' regardless of its physical composition or storage (st〇rage). [0111] In an embodiment, the computing system 1300 Can include suitable controls and / Communicate with large databases, perform a number of large-scale transaction processing and database from a large computer generated reports (mainframe computer). Computing system 1300 also includes a central processing unit 1304' which can include a microprocessor. The computing system 1300 further includes a DDR memory, such as a random access memory (RAM), for temporarily storing information and/or a read-only memory (reac[-〇niymemory, rom) for permanent The storage information 'and the mass storage device 1301' are, for example, a hard drive, a diskette, or an optical media storage device. In the typical case, the modules of the computing system 1300 are connected to the computer by a standards based bus system. Among different embodiments, the standard 201014571 • the quasi-sink/; IL platoon system can be, for example, a peripheral component interconnect (peripheral component

Interconnect, PCI), microchannel, smaH 'comPuter system hterface (SCSI), industry standard architecture (ISA), and extended industry standard architecture (ESA) architecture. [0112] The illustrated computing system 1300 includes one or more conventional input/output (j/〇) devices and interfaces 1303, such as a keyboard, mouse, trackpad, and printer. In one embodiment, the input/output device and interface 13A include one or more display devices, such as a screen, which can present a visual image to a user. More specifically, a display device is, for example, a graphical user interface (graphical

UserinterfaCe, GUI), application software data (applicati〇ns〇ftwaredata) and presentation of multimedia presentation (multimedia presentation). In the embodiment of Figure π, the input/output devices and interface 1303 also provide a communication interface to a number of external devices. Computing system 1300 can also include, for example, one or more multimedia devices 1302 'eg, a speaker, a video card, a graphics accelerator, and a microphone. ❹ Computing system device/job Operating system (OS) [0113] The computing system 1300 can operate on a variety of computing devices, such as a feeding device, a Windows server, a structured qUery language (sql) feeding device, and a Unix server, personal computer (PC), a large computer, a laptop computer, a cell phone, a personal digital assistant (PDA), a kiosk ), an audio player (audioplayer) and so on. Computing system 1300 is generally controlled and coordinated by operating system software, such as z/OS, Windows 95, Windows 98, Windows NT, Windows 2000, Windows XP 'Windows Vista, Linux, BSD, SunOS, Solaris. Or other compatible operating systems. In the wheat 37 201014571

Also, system. A typical operating system controls and schedules computer execution, providing a building system, network, and input/output services, such as a graphical user interface or other transaction. (proprietaiy) controlled by the operating system. One

[0114] In the embodiment of FIG. 13, the computing system 13 is connected to the network 1310, for example, via a wired, wireless or wireless wired and wireless connection, a communication line (10) address (3) 5, for example, using a plain old telephone service (p }血必 teieph〇ne 纪加从, 10 POTS) / A with the father to change the telephone network (puWic netwQrk pSTN>, the whole. Service digital network serv^ces out netw〇i^ isdn), fiber-optic distributed data interface ( Fiber distributed data interface (FDDI), regional network (L〇cai area network, LAN), wide area network (such as netw〇rk, WAN) or the Internet (Internet) of a data system (m〇 (jem SyStem) The network mo communicates with various computing devices and/or other electronic devices via wired or wireless communication lines (eg, persistent, intermittent, or periodic). In the illustrated embodiment of FIG. The router 131 communicates with one or more remote systems 1317 and/or one or more data sources 1319. [0115] A user access point (web_enabie (j user access 〇point) can be driven via a network, for example Remote system 1317 or data source 1319 A personal computer, mobile phone, laptop or other device connectable to the network 131 is accessed through the remote system 1317 and/or data source 1319 into the image processing and analysis module 1306 of the computing system 1300. Such a device There may be a browser module that can be implemented as a module that uses text, pictures, sound, images, or other medium to present data and possibly interact with the data via the network 131. [0116] The module or other output module can be implemented as a combination of an all points addressable display, such as a cathode ray tube 38 201014571 (cathode-ray tube, CRT), a liquid crystal display ( Liqyjd cryStai, a lcd, a plasma display or a combination of other types and/or displays. In addition, a browser module or other output module can be implemented as an input/output device and The interface 1303 communicates, and may also include a software having a suitable interface, such that a user uses a stylized screen element, Such as menu, window, dialog box, tool bar (t00lbar) and control items (such as radio button, check box, sliding scale) Etc.) to read the data. Furthermore, the 'browser module or other output module can communicate with a set of input and output devices' to receive signals from the user. [0117] The input device may include a keyboard, a scroll wheel, a pen (four) stylus, a mouse, a trackball, a voice recognition system (voice rec〇gniti (m system) or a pre- Designed switches or buttons (pre-designated switches 〇r buttons). The output device can include a speaker, a display screen, a printer or a voice synthesizer. In addition, a touch screen (t 〇uchscreen) can be used as a hybrid input/output device. In another embodiment, a user can interact more directly with the system, for example via a connection to a scoring generator (sc〇re generat〇r)

A system terminal that communicates over the Internet, WAN or LAN or similar network. [0118] In some embodiments, the computing system 13 can include a physical or logical link established between a remote microprocessor and a mainframe computer for rapid uploading, downloading, or It is an online viewing of interactive materials and databases. The remote microprocessor can operate the computing system 1300 via an entity, including a client server system or a main server system, and is operated, and/or via one or more Data source 1319 and/or one or more computing systems are operated. In some embodiments, a tenninal emulation software can be used on a microprocessor to participate in a micro-large computer link (micr〇_mainframe link). [0119] In some embodiments, the remote system 1317 located inside an entity operating the computing system 13A can internally read the image processing and analysis module 13〇6 as if it were from the central office 39 201014571 An application (applicati〇n) or program that works. User access point [0120j in the embodiment - user access point includes a personal computer, laptop (10) phone, global pGsitiGning system (GPS), - Blackbeny® Device, a portable computing device (p〇_ec〇mputing device) server, a computer workstation, a regional network of an individual c〇mputer, an interactive kiosk, A number of assistants, interactive wireless communication devices, handheld computers, embedded computing devices, and other systems [0121] In addition to the system described in Figure 13, the network 131 can be used with other sources or other § The ten counting device communicates. The computing system can also include one or more internal and/or external sources of data. In some embodiments, one or more data repositories or other sources may be implemented using a relational database a-database) 'eg DB2, Sybase, Oracle, CodeBase, and Microsoft (Microsoft®) SQL Server and other types of databases, such as a flat file database, an entity-reiationsjjjp database, and an object-oriented database and/or records as The main database (record-based database). [0122] Referring to Figure 14A', an exemplary method for determining or generating a disease, such as an eye condition, is assessed to generate a health level and a suggested medical time. The example shown in Fig. 14A is representative of retinal diseases, however, the disclosed procedures and methods can also be applied to other diseases or eye diseases. In this example, scan control and analysis module 824 is used to determine retinal thickness based on A-scan data inferred by subject 106. This information may include, but is not limited to, A-scan data from different A-scans. Scan Control and 40 201014571 • 〃 5^ mode, group 824 ' can also be used to read the data and algorithms in the disease risk assessment/diagnosis module (database) 808, based on the function curve revealed in Figure 14A. The _ 'membrane f degree is calculated to estimate the risk of the disease. The report/output module 8〇6 can be used to normalize the calculated risk assessment to an eye health letter or a digital grade or score. The report/output module 8〇6 can also be used to read the data and algorithm 'in the physician referral database 8〇4 to calculate the recommended time based on the calculated risk estimate value. ^ [〇123] Refer to ® 1 to make 'another example of a method or procedure to determine or cause a disease by comparing the scanned data with the disease risk assessment/diagnostic module (database) 8G8? The wind disease assessment ^ disease risk assessment / diagnostic module m contains, for example, minimum and maximum thickness data and algorithms, and the minimum and maximum thickness data and algorithms can be based on or in the form of a nomogram. In some embodiments, the secret is to generate scan data of the scanned portion of the eye to determine the thickness of the retina at any point, and compare the above information to histogram and/or _ (For example, a line graph showing the expected thickness at the above location or a given thickness of the disease) to infer a risk assessment. The system can also be used to generate an average thickness of all scanned webs and compare the above data to a histogram and/or nomogram to infer a risk assessment. [0124] The term "histogram" as used herein generally refers to a particular variable, such as a representation of an algorithm, curve, data, or other frequency distribution. In some cases, this variable is divided into multiple ranges, interyal classes, and/or - points on the graph (along the X axis). The frequency of occurrence is a rectangular column or the position of a point. Representation; the height of the square column and/or the point along the gamma axis is proportional to the frequency indicated by the observation within the range or interval or otherwise. A "histogram" as referred to herein may include, for example, self-scanning a user's eyes, resulting information obtained, or may include information obtained from a group of people. You can analyze the histogram of the former case to determine the average, minimum or maximum value, and • analyze the slope change or detect the shape or curvature of the histogram curve. The histogram of the latter case can be used to determine the frequency of observation of a measured value of a survey sample. 41 201014571 [0125] Among the examples in which the average thickness value is inferred from the scanning data, some of the symptoms/diseases may be represented by thickening of a localized area of the retina. Therefore, the above situation may not significantly affect the average thickness value (for example, if one part of the retina is a normal thickness). Therefore, a maximum thickness value may be required to detect abnormal thickening of the retina. In some embodiments, the maximum thickness value may be due to a false segmentation error. Therefore, the more stable method of determining the maximum value can also be to use 95% of the corresponding maximum thickness (or any value between 75% and 95%). 'The foregoing method is applied to the minimum retinal thickness or any other value, amount and/or detectable condition in the eye. For example, with a minimum retinal thickness as an example, if the user has a macular hole, there will be only a small area with a thickness of zero and may not be sufficient to significantly reduce the average thickness, but it will obviously be awkward. The second abnormality (abnormality) measured.

[0126] In other embodiments, the system can be used to generate a histogram of measured thickness and/or measured intensity values, and/or a slope or derivative of the intensity value, and/or to identify an abnormal condition. variable. For example, a change in the slope (calculated as a derivative of the adjacent intensity value) or a substantial change in the enthalpy may reveal a hyporeflective or hyperreflective configuration that may not affect the mean or Average

Intensity value, but can represent a disease or symptom. For example, the system can determine whether the distribution of retinal thickness of the measured portion of the retinal media is consistent with the normal population. Deviations from the “normal” histogram will result in a lower health level/higher risk assessment. [0127] Among various embodiments, the methods or procedures described herein can be used to determine or generate a risk assessment for macular lesions based on, for example, when stored in a disease risk assessment/diagnostic module (database) 808. When comparing a normal value database, the retina or the central fossa of the retina is abnormally thickened, and there is a high reflex (bright or high intensity) or low reflex (dark or low intensity) structure in the outer retina. There is a low-reflection (dark-dark) structure in the inner half of the retina, and retinal pigment epithelial cells (irregularity in the contour of the retinalpigment that deviates from the normal curvature of the eye or high transmission through the light of the retinal pigment epithelial cells) 42. Hypertransmission. 42 201014571 [0128] As mentioned above, there are several methods (4) that are fine or that produce several diseases or symptoms: risk assessment. In some embodiments, the scanned data is found by normal people. The data are compared to identify similarities or differences by the -column diagram and/or histogram. In other embodiments, 'scanning data and Compare the data found by people with the disease to identify similarities or differences by line graph and/or direct. The pathognomonic defects (features) can be derived from the line graphs of the sick patients, such as images. Representation of the similarity of the histogram or other data. [0129] In the f example, 'the retinal thickness of each region of the retina (optical nerve, foveal fossa, temporal retina) "Normal" data "column as a histogram" and compares the measured, detected 'scanned' or encounted values with this "normal" data (eg histogram) to Decide on the relative risk of disease or other diseases in the net. The same method can be performed on the thickness of the nerve fiber layer (NFL) to detect glaucoma β. In other embodiments, the detection or generation of a risk assessment of glaucoma is performed by analyzing the same line. (collinear) Α Scan data for execution or generation. Curvilinear thinning is observed to indicate the presence of glaucoma because glaucoma tends to thin the thickness of the nerve fiber layer in curvilinear bundles. The neurofibrillar layer radiates from the optic nerve in a curvilinear fashion, just like iron filings around a magnet. Measuring and analyzing a series of A-scans along this curved path can be helpful in identifying the thickness of the glaucoma, which is characteristic of glaucoma. Such analysis may focus and/or surround the optic nerve or concentrate on and/or surround the foveal fossa, or elsewhere. In another embodiment, the detection and/or production of a risk assessment for glaucoma is performed or generated by analyzing the epithelium of the optic nerve to determine the volume of the optic disc cup. [0130] This system can also be used to detect and/or generate a risk assessment of eye clarity, wherein the system accumulates A-scan data on the Z-axis and combines some or all of the a-scan data with a line graph. Values or other values are for example compared to a histogram. In general, a darker A scan will likely represent a situation where media turbidity occurs, such as cataract 43 201014571 (cataract) 'which reduces eye clarity (thus increasing the risk of a subject having a clearing problem, such as a cataract) . .

[0131] The system can also be used to detect or produce a risk assessment of the normal curvature of the retinal pigment epithelial cells (_) from the normal curvature of the eye (dnisen, retinal pigment epithelial cell stripping (RPE)). Such retinal pigment epithelial cell characteristics can be achieved by combining the detected retinal pigment epithelial cell layer with a polynomial curve that mimics the expected eye curvature and using a computer algorithm to analyze or compare these The difference between the curves is detected. In the related example of Figure 15, the system can be used to subtract the polynomial curve that mimics the expected curvature of the retinal pigment epithelial cell layer 1502 from the detected retinal pigment epithelial cell layer curve 15 〇 4, and the resulting difference/value 1506 is analyzed and/or compared with values from normal and/or diseased eyes (eg, in a histogram line graph) to generate a diagnostic or risk assessment. The above methods and procedures are similar to a tortuosity measurement because of a bumpy retinal pigment epithelial cell compared to the detection of smooth retinal pigment epithelial cells commonly found in young, healthy individuals. The detection results will usually have more deviations in a polynomial curve. [0132] Such retinal pigment epithelial cell detection can also be used to detect an increase in transmission of retinal pigment epithelial cells, which is essentially the meaning of degeneration or atrophy of retinal pigment epithelial cells. In some embodiments, the system is used to analyze tissue layers above or below the layer of retinal pigment epithelial cells. The retinal pigment epithelial cell layer can be segmented by using an imaging segmentation technique. In some embodiments, the system is used to accumulate all intensity values under the detection of retinal pigment epithelial cells. When presenting atrophy, there are usually many high vaiues below the retinal pigment epithelial cell line, which cause high integral values' and increase the patient's symptoms of severe maculopathy, such as geographic atrophy (geographicatrophy) ),risks of. [0133] Referring to Figure 16, the system can also be used to detect or generate a risk factor for abnormal intensity within the retina. In some embodiments, the system is configured to detect a midpoint between the 1606 and the retinal pigment epithelial cell detection line 1608 based on an internal 44 201014571 internal Smiting membrane (ILM) to segment the visual network. It is an inner half 16〇2 and an outer half. 1604. In some cases, a blur filter (such as Gaussian blur, radial blur, or other) is applied to the retinal tissue to remove speckle noise and/or other Noise. For both internal and external retinal regions, a first derivative of the intensity value (related to position, such as d/dx, d/dy, or others) can be calculated to determine the slope of the curve to A large number of areas that are darkened by darkness or darkened by sputum are differentiated across the lateral dimension of the tissue. For example, the intensity or derivative in the retina can be compared, for example, to a general histogram, where the internal retinal low intensity may be an indicator of cystoid edema; or where the outer retina is low-intensity It may be an indicator of cystic macular edema, subretinal fluid, difibse macular edema; or the external retina may be diabetic (diabetes or diabetes mellitus) (may cause sugar Diabeticretinopathy or retinal damage caused by, for example, diabetic complications (complication), or an indicator of age-related macular degeneration. [0134] The data for normal patients can be used to compile a histogram of intensity and/or slope (derivative) data to represent the expected value of the person. Data for people with various diseases can also be placed in histograms of intensity and/or derivative (slope) values to represent the expected values for those with the disease. In some embodiments, a relative risk will then be developed for each entry on the histogram so that this risk can be applied to an unknown situation. For example, in some cases, a 10% chance of having an external retinal strength value equal to 〇 has a retinal problem of 85%. Therefore, such a user can receive a health rating of 15. In another example, there is a 100% chance that any internal retinal point is less than 1 ,, so these users can receive a health rating of 5. [0135] Alternatively, as described herein, the foregoing methods or procedures can also be used to pattern thinning of the macular portion and/or peripapillary nerve fiber layer, or for cup-shaped expansion of the optic nerve head ( Enlargedcupping), compared with a database of normal and abnormal values stored in the disease risk assessment 45 201014571 = model (fault) f, and a risk assessment of glaucoma. Similarly, for the evaluation of the extraction or development of uveitis, for example, a __ histogram of the expected intensity values above the internal retinal surface (in the vitreous) can be used. There is a large, silky spot in the vitreous cavity (the _ 〇 (eg high-intensity area) may represent uveitis, and this may represent a need for referral (referra〇. The aforementioned methods and procedures may also be used based on The intensity level of the image signal is compared to a database of normal and abnormal values stored in the Disease Risk Assessment/Diagnostic Module (Database) 8 (10) to determine or generate a risk of eye disease. [=136] In other embodiments, the method or procedure may also be characterized by high reflection characteristics in the vitreous cavity of the grade and normal and abnormal high reflection characteristics of φ stored in the disease risk assessment/diagnosis module (database) 8〇8, A risk assessment for determining or producing uveitis may also be used to determine the specific symptoms of the disease based on the comparison of the specific symptoms of the disease and the disease = disease risk assessment/diagnosis module (repository) 8 (10) To determine or produce a risk assessment of the anterior eye disease, specific symptoms of the disease such as cystic retinopathy (eystGidretinaldegeneration), fine material (4) (Quterretinal Edema), subretinal fluid, subretinal tissue, macular hole, glass thief, gonadotropin epithelial lion and/or retinal pigment epithelial cell atrophy. In some embodiments, the system is used Perform a sample alignment 〇emplate matching) 'where the system scans a user for A-scans, also known as unexplained A-scans, and is known to be associated with disease characteristics, such as subretinal fluids, etc. The pattern database performs detection, comparison and/or matching features. [0137] Referring to Figure 8 and Figure 9, the optical coherence tomography system is used to allow the user to eliminate dilation. Self-managing an optical coherence tomography scan of the user's eye does not require the intervention or involvement of a physician and/or a technician to perform the alignment of the user's eyes with the system, perform optical coherence tomography scans and/or Or interpreting data from a scan that produces or determines a risk assessment or diagnosis, ie, obtaining a risk assessment or diagnosis of various diseases and conditions. In an embodiment Medium, optical same - 46 201014571 The tomographic scanning secret 1GG can perform a screening between less than 2 minutes, 2_3 minutes or 2_5 minutes. In some embodiments, the binocular system can be used by the user Optical coherence tomography system 1 〇〇 self-alignment such a binocular system optical __ county New (10) speed health, aim to sweep (four) eyes without repositioning, and can make optical coherence tomography system 1〇〇 Scan a person's unsound eyes, because when the person's healthy eyes are chasing the gaze mark, the person's unsound eyes will follow the person's healthy eyes. Therefore, the optical coherence tomography system is unified. 〇 Reduces the cost of performing an optical coherence tomography scan, thereby making it easier for more people and/or users to receive optical coherence tomography and protecting millions of people from loss of vision, due to disease Or the condition can be prevented by early presence (earlierdetectj〇n). In one embodiment, the optical coherence tomography system 100 is designed to have a small size and/or portability so that the optical coherence tomography system 100 can be placed by a woman or woman Pharmacy retail store (retyimgji) or 疋 shop, medical imaging facility (medical imaging facility), grocery store (store), library and / or transportation (m0biie veijicie), bus, van (van), family physician (generalpractitioner ) Or in other doctor's clinics, so that people can use the optical coherence tomography system without using a doctor. [0138] The optical coherence tomography system 100 can also incorporate other features. In some cases, other features can increase the performance of the system. [0139] FIGS. 17A to 17C show B-scans obtained when the optical coherence tomography system is located too farther than the eye, at a position providing an increased field of view, or too far back. As shown, when the optical coherence tomography system is too far forward or too far behind the eye, the field 〇f view (which refers to the size or width of the b-scan) is shrunk. . 18A through 18C further show how a field of view of the system 1 can be affected by the position of the optical tonal tomography system relative to the eye. Figures 18A through 18C each show two probe beams 2005a and 2005b that are emitted from an optical coherence tomography system along different tracks, as shown, for example, by rotating a galvanometer to detect the retinal 201014571. section. For example, rotation of the galvanometer can cause light to be emitted along different trajectories as described above. These trajectories can cross each other at a point of rotation 2010. The movement of the galvanometer (Example 2 - Rotation) can cause the probe beam 200 to rotate about the point of rotation 2〇1〇 as or as the path of (10). In a typical situation, the system will emit multiple beams 2〇〇5a.2〇〇5b so that the eye tissue can be fully imaged. Thus, in some embodiments, there are many other shots that should be a and 2 嶋 (10). Wei Guangsi-Spin_ or the point of the genus is crossed. In some embodiments, the location of this point may coincide with a focus of the beams. Beams 2005a and 2005b and each beam in between (unpainted to cause the eye to reflect light, so that the A-scan data can be the beam associated with each beam. The 18AS18C shows an area that can be imaged by multiple beams) 2015. Therefore, the emitted light can sweep through a whole column of the retina. The position of the rotation point 2〇ι〇0 can affect the horizontal dimension (such as length or width) of this area 2015. The area 2〇15 can be described as one The field of view can be related to a large amount of data among _B scans or a plurality of sets of eight scans above a critical intensity. [0141] In FIG. 18A, the rotation point 2010 is located behind/back side of the pupil 2030. Beams 2020a and 2020b incident at the incident angle will not be able to enter the eye because they will be blocked by iris 2025. In this case, the angle of incidence and thus the imageable eye area 2015 will be limited. [0142] In Figure 18B In the middle, the rotation point 2010 is a pupil plane located in the pupil 2030 (for example, in the plane of the pupil, since the light beam intersects at the rotation point 2〇1〇, no incident light will be blocked by the iris 2025. Therefore, as shown, the imageable eye area 2〇15 is not limited by the obstacle formed by the iris. Therefore, a larger field of view can be provided. [0143] In FIG. 18C, the rotation point 2010 is Located before/before the pupil 2030.

Figure 18 is the same in the human 'so that the beams 2020a and 2020b incident at a high angle of incidence will not enter the eye' because they will be blocked by the iris 2025. In this case, the angle of incidence and thus the imageable eye area 2〇15 are limited. Therefore, it can be seen that the area 2〇15 detected in the diagrams "A and 18C" is reduced by - compared to the area 2015 detected in Fig. 18B. 48 201014571 [〇144] Referring again to Figs. 17A to 17C The example shows how the B-scan can be affected by the position of the movable element or the moving point. Compared to the rotation point 2〇ι 〇 at a more ideal position (Fig. 17B), when the rotation point 2_ is too far ahead ( Figure 17A) or too little tissue will be imaged. In each case, light from the center of the eye is reflected back toward the optical tonal tomography system. However, when rotating When the position is 'non-optimal position, the light from the extreme position of the eye cannot be reflected back toward the optical coherence tomography system. As shown in Figure 18, the light is theoretically in front of the domain. Iris scattering. By analyzing the B-scan results obtained from different positions of one or more movable elements, it is possible to determine the field of view, that is, the hybrid energy of the (andthus) optical coherence tomography system. Bit ^. Then you can By using - increasing the visual field of the optical imaging layer, scanning the New Green line (for example automatically) - risk assessment or diagnosis 'when the movable element is in the -__ position, an increased field of view is obtained, and the field of view is increased It will be greater than when the movable element is in a different second position; a field of view is obtained. [0145] Therefore, in some embodiments, the intersection rotation point is placed at a specific position of the eye to 'for example, to increase the field of view and / or reducing the iris 2 〇 25 for the blocking of incident light may be advantageous. For example, the location may include: a position in or near the pupil of the user's eye, a position of the iris of the user's eye - a position, the user The position in the crystal of the eye or the position on the back side of the pupil of the user's eye. Other positions are also possible. Furthermore, some embodiments may not include a well-defined cross/rotation point 2_ at all. In some embodiments The optical coherence tomography system 100 is used to adjust a front-to-back distance of the optical homography scanning system relative to the eye or a working distance of the optical coherence tomography system. Figure 19 shows an optical coherence tomography scan. At least one movable optical component (eg, lens (optical component 2〇5)) 〇 at least one position of the movable optical component can determine, at least in part, the position of the rotational point 2010 and the working distance of the optical coherence tomography system In some embodiments, for example, the working distance may determine, at least in part, the position of the point of rotation 2010. For example, the working distance 21〇5 may be measured as the outermost lens of the eyepiece or the window and the point of rotation 2010, or the distance between a position of the eyepiece cup 12〇 and the rotation point 49 201014571 2010. (Other reference positions on the optical coherence tomography system ι〇〇 can also be used.) Therefore, increasing the working distance can turn the rotation point Lion Moves to the Front Side In some embodiments, the optical coherence tomography system can be moved relative to the eye. When changing the position of at least one movable component, the optical coherence tomography, or the optical coherence tomography system itself, the position of the rotation point 2 relative to the eye may be changed, and these changes may be based on The reason described above with respect to Figures 18A-C affects the '&quot;&quot;&nbsp;Newfield of view of the retina. [0146] As described above, it may be desirable to locate the intersection of the transmitted probe beam or the rotation point 2_, or another region to reduce the above-described barrier. At the time of the measurement, the pair-view scan, the -B scan, or the eye can be monitored by: == domain-size. Movable-movable or adjustable optical element, such as - or multiple lenses (optical element 2G5), adjustable surface optics 2ig, eyepiece cup 120, and eyepiece 203' to adjust at least partially control the field of view The position of a working distance, eyepiece 203, and/or optical coherence tomography system (partially or wholly) relative to the eye. This light can change - the rotation point, such as positioning the screw in or near the plane of the pupil. This adjustment allows more secrets (e. g., a wider range of probe beam trajectories) to enter the eye from the system than thereby increasing the field of view. By way of example, this adjustment can be achieved by reducing the amount of light that is blocked by - or multiple eye configurations (e.g., the iris) to increase the probe beam orientation ((4) ray (10)) that can be scanned into the eye by -Β. [(4)] The movable platform and other actuators or mobile devices may be used to position the optical device in the anteroposterior direction or the optical coherence tomography system, or may be adjusted to provide optical axes along the optical tonal tomography instrument (optical). Movement in the axial direction. Thus, the position of the movable element (eg, in the axial direction along the optical axis of the optical tonal tomography instrument) can determine the front and rear side positions of the point of rotation. [0148] In some embodiments, A movable platform, for example for laterally (eg horizontally) movement, may be included. Such a moving platform or activation may determine the horizontal position of the rotating point. For example, if the platform is positioned too far inside or On the outside, the iris may block the part of the light entering the eye, which is used to form, for example, a side or outer portion of the 201014571 of a B-scan. In some cases, if the platform is too _, the iris can resist scanning. - the inner part, · and in other cases, it can block the outer part. Therefore, the left and right eyes can be compared (for example, B-scan). Another, then you can adjust the activity test platform with a smaller field of view of the eye, in order to increase depending on the eye of this ❹

In this case, in some cases, the -B sweeping thief is a detailed analysis of its syntactic tonal fault sweep, green shoot reading or fine comparison, whether the mosquito platform or the starter - horizontal (such as horizontal) moves For the benefit. For example, you can adjust the platform or the starter in the use case ^ = - Note _ - _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ After the platform or actuator is finished, it affects the alignment of the pupil distance. In addition, the movement of the platform or actuator can affect the sample material to be imaged, and the location of the secret component can be modified to account for this effect. In many embodiments, the movement of the platform can be shifted to - or multiple elements of the tonal tomography system. For example, in some embodiments the platform can support a lens (optical element 205), an adjustable optical device 210, a split flat Aa t 230b, and/or a mirror cast or 260b. One such sound can be prepared for each eye. From the example, the components supported by the platform are 70 pieces that make the platform move without shadowing or "staining the angle of the output. In some cases, spanning two eyes. The movement or adjustment (for example, a horizontal platform) can be asymmetrical, such that the relative movement of one eye is not parallel or different from the movement of the other eye. Integer '- or multiple movable or adjustable optical components (7), such as systemic, multiple locations, and data (such as optical coherence tomography) can be obtained at these locations. Multiple moveable/adjustable optical pre-sets, this off position is based on the expected itr comparison at each position. Image miscellaneous, such as B-scan, line split case, one or more sets of A-scan or one or Multiple B-scans, one or more positions of one or more movable/adjustable elements. Each 8 scans or 51 201014571 Each set of A-scans can be unique with one or more movable/adjustable components (distinct ) position / setting associated. For example, scanned - Properties (eg, image quality measurements or signal strength values) can be compared to multiple B-scans or multiple sets of A-scans to determine the recording position or setting of one or more movable/adjustable components. In this case, the taste is spread over all of the cumulative intensities of the plurality of B-scans or the plurality of sets of A-scans. In another case, a plurality of A-scans or a set of A-scans containing a B-scan are specified. The intensity of the point or position (eg, the sum of the cumulative intensities) is used for comparison. For example, a parameter can be defined as a retina that is all A-scan or a set of A-scans throughout a B-scan. The sum of the intensities of nearby locations (approximatel〇cati〇n). This parameter can then be compared to multiple sets of A scans or multiple B scans. One final position/set of one or more movable/adjustable elements can be set (resultantposition /setting) is defined as a position/setting with a set of eight scans or one B scans. 'This set of a scans or this B scan has a higher than one threshold or a maximum value (eg all maximum intensity) corresponding to this parameter Numerical value, measurable, Other values are calculated or considered, and other methods can be used to determine the desired position/setting and thereby increase the field of view. [0152] In some cases, multiple (eg, a predetermined number) of b-scans or multiple sets may be obtained. A scanning, and determining a preferred position/setting of one or more movable/adjustable elements as a position associated with one of the B-scans or one of the sets of A-scans/in another case, The data is used to predict a preferred location/setting, which may or may be a location/setting relating to the collected data. For example, an extrapolation or interpolation may be used. (interpolation). In some cases, b-scan #戈 is the scan group data for dynamic collection. For example, if a displacement of one or more movable elements causes a better change in a parameter from a first position to a second position along an axis, then the next movement can be avoided. The direction of the impetuous change change). In another example, one or more movable elements can be repeatedly adjusted w until a variable exceeds one threshold. Other methods and methods are also feasible. [0153] We may anticipate positioning or setting one or more movable or adjustable elements' such that a rotational point of the probe beam emitted by the optical tonal tomography system is: 52 201014571 . Or near the pupil plane. Assuming that the probe beam is rotated about a position that is not displaced longitudinally toward the pupil plane, the light emitted by the portion of the self-optical tomosynthesis system may be blocked by, for example, the iris before reaching the focal point. Assuming that the probe beam is rotated about a position that is not displaced toward the pupil but toward the cornea, then some of the light emitted by the optical tonal tomosynthesis system will reach the focus but before reaching other ocular structures such as the retina, Blocking β by, for example, the iris, by rotating the beam emitted by the optical coherence tomography system around a point at the pupil, an eye configuration surrounding the pupil, such as the iris, may not block the input light. Thus, rotating the probe beam at the pupil increases or maximizes the amount of tissue that can be imaged by the instrument. φ [0154] In some cases 'a position of the retina is determined for multiple 3 scans or sets of scans, each B scan or each set of A scans with one or more movable or adjustable 70 pieces Different locations or settings are associated. The position of the retina can then be used to predict the pupil position and the moveable/adjustable element can be positioned/set such that a point of rotation is at or near the predicted pupil position. In some cases, an ocular structure, such as the cornea, iris, retina, vitreous, anterior chamber (mail (4) sinking chamber) or tear film interface (anal film interface) or from another structural feature color generation), For example, the edge of the eyelid, the nasal bridge, the cheekbone (maxilla), the frontal bone, the eyelid, or the surface of the skin are determined, but can be moved/adjustable. The component is positioned/set based on this determined position. The determined position can be used to predict a location of another configuration, such as a pupil. [0155] In some cases ... or the expected position or 忒疋 of a plurality of movable or adjustable elements is not based on optical coherence tomography data obtained for a particular patient. For example, the σ position or weight may be selected based on normative data, which includes, for example, based on the population as a reference or quantity - a standard position or a slave. For example, for each patient, a field of view measurement can be made for each location or setting of the - or multiple movable/adjustable components. In the -first case, decide for each patient - although ^ or mosquito. For example, the fresh position/setting can be the preferred position/minor of the reduction, the median or the majority (m〇de). In a second case, comparing the measurements of all 53 201014571 patients with the - door-line H may categorize the standard position or the mosquito: most patients' positions exceed this. In some embodiments, the movable mechanical component is in the form of a fresh position, and the component can be based on a fresh arbitrarily positioned mosquito or a mosquito-side. This position/setting can be used as a selected position/setting to be used as a starting point for measuring different fields of view as described above for different positions/settings to determine a position with an increased field of view/ set up.

[0156] In some embodiments, the standard position/setting is not based on optical coherence scan data but is based on structurally obtained data obtained by other means. For example, the standard position can be based on an average distance between the pupil and the sun, the average front-to-back distance between the shout and the pupil, the average front-to-back distance between the corner and the pupil, or In the chin (an average front-to-back distance between ehil^ and a pupil. This standard position/setting can be based on different patient groups. For example, this standard position/setting can be based on the age of the individual, Gender or race. [0157] In some cases, the location/setting of the plurality of movable/adjustable components may be based, at least in part, on sensing H data. For example, the sensor may a location of a patient or a patient characteristic (eg, eye, pupil, iris, chin, eye), which can be used to determine the eyepiece 2〇3 or optical coherence tomography system Touch position

Or set. In the case, the side-to-side position is used to measure the pupil verification, which is used to determine the position of one or more movable elements. [0158] Thus, in some embodiments, an optical coherence tomography system (shown in Figures 1 or 3) includes a sensor or tracker. The sensor or tracker can determine the user's position, the fairy's - or both eyes and / or the eyes of the person's eyes - or multiple configurations (eg - visual, pupil, thief crystal) . In some embodiments, the sensor or tracker is located or connected to the body 1, 6 or the zero gravity arm 116 or even the eyepiece cup 12G. In some embodiments, the towel is smashed or chased into a separate device from the body 106. In some embodiments, the sensor or tracker is connected to or included in the system shown in FIG. 54 201014571 [0159] In the case, the sensor emits light or ultrasound from a light source and detects the reflected light. Light may be from a structure of the user's eye, such as fine, iris, pupil, retina, vitreous, anterior or tear film interface, or features from another structure such as the edge of the eyelid, bridge of the nose, humerus (maxilla) ), frontal bone, eye face or skin wide surface, reflected back. The sensor can determine the position of the configuration based on the time difference between the time the light is emitted (e.g., a pulse) and the time at which the light is detected. In other cases, other types of pulsors or trackers can be used. For example, an optical colloidal scanning scan can determine the position of an eye structure based on interference or reflectivity results. ❹ [〇16〇] In some embodiments, the position/setting of one or more movable/adjustable elements is based on a combination of methods. For example, the position/setting can be determined based on the non-optical coherence tomography scanning H data and the optical coherence layer scanning. The position/setting can be determined based on the field of view data and the sensor data and/or the determined standard position. The location may be based on the sensor data and the determined fresh position. In some embodiments, at least - standard data or sensing data may be used to assist in determining the starting point for several optical coherence tomography measurements. It is then used to decide to provide a position or setting that further increases the field of view. [0161] Other approaches are also possible. Among some of the embodiments, for example, an optical ❹ 断 扫 扫 1 GG GG 1GG contains - Cong Tuo. In this case, the secret 1GG can be used to

Minor adjustments. This adjustment may include any adjustments described herein, such as - or - for a plurality of movable optical elements - such as increasing the field of view of the system (8). In one case, the distance between the body and/or the domain of the optical element is adjusted to a second distance from the -first distance. In some embodiments, the leg rest is movable, but in other ties, the miscellaneous gj formula. This distance can be based, at least in part, on a standard value, such as - the average offset between the chin and the pupil (e.g., in the fore and aft directions) or - the average distance between the pupil and the eyepiece cup. In some cases, this distance 55 201014571 to > is determined based on the sensor's read value. For example, a sensor can measure the position of the user's eyes, rails, or iris. This sensation may include - Guangxiang. The tomographic scanner n may or may include another optical overtone. For example, as described above, the detector can emit a ray and determine the time elapsed between the transmission and the receipt of the reflected light (e.g., a pulse). The sensor can include a weight sensor&apos; to sense, for example, the position of the patient&apos;s chin. - The sensor can be used to make the user's chin - position or weight. In some embodiments, the wire is movable, or the body and/or the eyepiece of the optical coherence tomography system can be moved relative to the chin rest and the field of view as monitored above. The changes are also feasible. [62] In some embodiments, one or more of the one or more movable/adjustable optical elements can be manually adjusted by the patient. For example, the patient can be instructed to adjust the position/setting based on - or multiple images seen by the patient. For example, the patient can be instructed to adjust the position ' until two or more images (e.g., working distance images) have been aligned. The alignment can be corrected with the eye to the optical off-saw scanner. Other designs are also feasible. [0163] In some embodiments, system 1 can be used to screen for one or more ophthalmic conditions. In other embodiments, the system 1 can be used to monitor one or more symptoms. In some cases, patients have symptoms that require regular monitoring. For example, symptoms may worsen 'may require different treatments; or symptoms may improve, and may require a treatment or follow-up. Fine, frequent regular appointments to a health care provider can be expensive and inconvenient. Inconvenient and busy schedules between health bribe providers and patients can reduce the frequency of appointments to - not as low as expected, making a health care provider less likely to be at the earliest. It is possible to make it easier to record, cheaper, faster and/or easier to monitor by using the patient's optical shut-off sweep (4) system (10) for self-management and monitoring. [0164] As described in more detail below, the system may be notified - specific symptoms. For example, a physician may (for example, indirectly) indicate that a patient is suffering from a certain symptom or convulsion. The risk of suffering from a certain symptom. Based on the optical residual measurement obtained by the system, the system 100 can be used to determine if the symptoms are improving or worsening. The system can (for example, every time 56 201014571 an optometrist produces a special fruit) to inform the health care provider (for example, whether a 2 or a patient is obtained by the system). The result can be referred to as positive health care. For example, the results may indicate that the disease is worsening (as a result of the care of the provider, the provider can consider the alternative treatment strategy to provide New Zealand (eg health care)

❹ [Fig. 20] shows an optical homomorphic tomography system j program 3000' and Fig. 21 shows a two block diagram of an optical coherence tomography system lion. The line of the components of the system fiber shows the connection between the tillers. In some embodiments, the connection is in the secret t, and in some embodiments, other connections exist. The connection may be a direct physical connection, a virtual connection, a physical network connection (e.g., using a telephone line), and/or a wireless network connection. Other connection types are also possible. In some cases, system 3050 includes other components not shown in FIG. 21, and in some cases, system 3〇5〇 does not include one or more of the components shown in FIG. Similarly, in some cases, program 3000 does not include one or more of the steps shown in Figure 20 and/or includes other steps. The steps of the program may also be rearranged. [0166] In step 3005 of routine 3000, information relating to an ophthalmic symptom can be received. The information can be read by reading a data storage device such as a card having a magnetic strip, a smart card, or a USB device. Information can be received electronically, wirelessly, or received over a network (eg, via an internet connection). [0167] Information can be received by an input device 3055 of system 3050. For example, input device 3055 may include a receiver 3060 (e.g., a wireless receiver). Receiver 3060 can be connected to a regional or remote network, such as the Internet. Although in some embodiments, receiver 3060 receives signals from a wireless device, it is not in other embodiments. For example, receiver 3060 can be used to receive a telephone line. Input device 3055 can include a card reader 3065. Input device 3055 can include a USB drive reader 3070. In some cases, the input device receives (e.g., '57 201014571 through receiver 3060) information from a server 3075. For example, a physician can send information to server 3075. The server can store information and can then transmit information to the input device when a user is ready for a scan. For example, the user can enter an identification code or can use a device containing an identification symbol, and the server 3075 can then send information corresponding to the user to the input device 3055. Although only one server is mentioned above, it is possible to use, for example, one or more servers or computers in a network. [0168] Information can identify a symptom or disease. For example, information can indicate that a patient is suffering from a specific condition (eg, with age-related macular degeneration, macular edema, diabetic retinopathy, or glaucoma). Information can indicate a past severity of a symptom, such as the severity of a symptom at a previous appointment. Information can indicate a threshold of symptoms (thresholdindication). For example, the information may indicate that the patient and/or a health care provider (e.g., a physician or optometrist) should be notified if the symptoms worsen to a particular amount predicted by a particular measurement. Thus, system 3050 may not need to screen for disease, but may monitor the progression of a particular condition. (However, in some embodiments, system 3050 simultaneously monitors at least one symptom and screens for one or more other symptoms). In some cases, program 3000 does not include a step 3005. [0169] In step 3010, patient information is loaded. Patient information can include a history related to ophthalmic symptoms. For example, patient information may include an optical coherence tomography measurement or an output from a previous scan associated with this measurement. Patient information may include health care provider information (eg, a name, address, email, and/or phone number of the patient's physician). In some cases, the health care provider information and/or the identification of a patient is received (e.g., along with the information received in step 3005). The identification symbol can include, for example, an identification code or a patient name. Information can be loaded by a storage component 3080 (e.g., a local or remote computer). For example, the information can be loaded from a local memory or can be received wirelessly by a server 3075 that can have information stored on a storage element 3080. In some cases, the information is loaded into a data storage device that can be provided for a patient, such as a smart card or a credit card. Therefore, the input device 3055 can receive patient information. In some cases, program 3000 does not include a step 3〇1〇. 58 201014571 . [G17G] In the age of 彳 t ' patient will be - Zhang Ka # insert - card reader. The card is encoded with a card = number or code. The card number or code is transmitted to a remote location, for example, a device that provides information about the symptoms, patient information, care provider information, and the like. [0171] Although only the single-storage element 3_ is shown in FIG. 21, there may be multiple storage elements. For example, a portion of the storage element 3080 can be physically coupled to the optical tonal tomography scanner H 3G85 or a plurality of aged components can be physically coupled to the feeder 3075 and - or a plurality of defective component faces can be physically coupled to the device. In some cases, the '-removable and non-removable storage device elements 3_ are connected to the optical 308 麟 麟 308 308 3085. Its (4) configuration is also feasible. [0172] Optical coherence tomography measurements can be obtained at 3〇15 t. These measurements can be any such measurements as described herein. Measurements can be obtained by an optical coherence tomography instrument 3085. The optical coherence tomography instrument Na may include elements as described herein, such as some of the elements associated with system 100. For example, the instrument 3085 can include an eyepiece 203, a light source 240'-interferometer 3〇9〇, a side device 3〇95, and/or an electronic device 31〇〇. The eyepiece 203 can be used to receive at least one of the eyes of the user. Light source 240 can be used to output light that is transmitted to the user's eyes via eyepiece 2G3. The interferometer can be used to induce optical interference by the light reflected from the eye of the user. The thinner 3095 can be set to interfere with the G Zhuangxian. The electronic device is logically coupled to the fine nna and can be used to analyze optical tonal tomography measurements obtained by the interferometer 3090 described herein, and/or can be used to determine and detail a state correlation of subsequent ophthalmic symptoms. One ophthalmology turns out. For example, optical tonal tomography instrument 3085 can obtain sputum scans, B-scans, or stereo optical tomography data. In some cases, the type of spur optical tonal tomographic scan measurement depends on information about the ocular condition (〇pticalc〇nditi〇n), such as the information received at step 3005. For example, if a patient is suffering from a narrow-angle green eye, the optical coherence tomography instrument 3085 can measure the depth of the anterior chamber and abandon a wider imaging of the eye. Alternatively, the anterior chamber depth measurement can occur immediately prior to scanning the posterior side of the eye. 59 201014571 _] As described in the above detailed description, in some embodiments, a z-axis offset adjustment platform 290a or 290b is adjusted prior to screening or testing of the optical coherence tomography, thereby changing Wei The part of the eye that is imaged. In some cases, the elements of the optical tonal tomography scanner (e.g., the z-axis offset platform or 29〇b) are moved until the posterior configuration (e.g., the retina) is imaged. The tree may initially be positioned to image the structure of the _ _ _, and the reticle canister image is imaged. In some cases, instrument 3085 can thus scan a front side configuration and then scan a back side configuration. By way of example, in a procedure for positioning the rear side configuration, the front side configuration can be imaged. In some cases, the posterior configuration is imaged prior to the front side configuration (e.g., immediately prior to it). Just in step 3〇2〇, an ophthalmic output is based on optical coherence tomography measurements. In some cases, the electronics of the optical coherence tomography instrument 3〇85 determine the ophthalmic output. It is to be noted that in this example, although the electronic device (nine) is shown in the optical coherence tomography instrument 3085, in some embodiments, the electronic device 31GG is on the on-far device. For example, the data from the scan can be sent to the ship B 3075' and the electronic device of the ship stomach 3G75 can be divided into four materials and determine the ophthalmic output. In some practical respects, the electronic device can be in both the optical shutdown scanning instrument 3085 and a remote device. [0175] The type of output may depend on the information received in step 3. The output can be quantitative or qualitative. For example, the output may include, among other things, a retinal anterior membrane, macular holes, saccular macular edema, hard exudates, neovascularization (neovasculgrizati〇n), intravascular microvascular abnormalities, cotton wool. Cotton wool spots, micro aneurysms (micr〇aneurysms), intraretinal hemorrhages (ifltraretinal hemorrhages), subretinal fluid, subretinal tissue, subretinal hemorrhage, retinal pigment epithelial cell stripping, drusen or retinal pigment The presence of structures such as atrophy of epithelial cells. Measurements such as anterior chamber depth or fovealthickness may also be included. It can also include A-scan 201014571 from many optical coherence tomography scans - aggregated measurements collected, such as macular volume, volume of the meridian layer, optic disc volume, subretinal fluid volume, glass membrane疣 Volume, Glass Membrane Area, and Mapped Atrophy Area These measurements can be based on a scan of the overall area, or subsampled from a subset of scan points. The output can include a count of the configuration, such as a drusen or microaneurysm, or a measure of the density based on its area compared to the total area scanned and based on its volume relative to the total volume of the scanned tissue. It is also possible to base the reflection intensity of the A-scan data itself from the optical coherence tomography scan. For example, media sharpness measurements can rely on optical coherence tomographic signal intensities, while hard exudation measurements can rely on the distribution of intensity values of the inner and outer retinas to brighten objects. [0176] The output may be based at least in part on the patient information loaded in step 3〇1〇. For example, the output can compare the measurements obtained in step 3〇15 with the previously obtained measurements. This comparison may include a pair of alignment procedures, such as a pair of bits of the retinal image obtained over multiple scans. The comparison can be an overall numerical comparison across multiple locations in the eye (eg, area, volume, sum or cumulative value beyond a region such as the retina, nerve fiber layer or cup or portion thereof) or, for example, thickness or structural classification (structureclassification) The point-by-point (p〇int_by_p〇int) value comparison. Therefore, changes such as the width, area, volume, or thickness, and the appearance of new structures can be recognized. The previously obtained measurements can be stored on storage element 3080, which can be included within optical tonal tomography instrument 3085 and/or server 3. The stored measurements may be associated with a date and/or time at which the measurement was taken or a code indicating, for example, a scan number (e.g., a code associated with a card entered by the user). Thus, when determining the output, the most recent scan or another reference scan can be identified and the data from this scan can be loaded (or transmitted from server 3〇75) for comparison. The comparison can then be performed (e.g., by electronic device 3100). In some cases, a computer can include an electronic device 31. Thus, the computer can be used to perform one step, which is performed by the electronic device 31 in the embodiments described herein. For example, the computer can compare two or more scans, compare one scan to one threshold, calculate a percentage change rate of a measurement, and the like. The computer can be included in the optical coherence tomography sweep in 201014571. In some embodiments, the computer is coupled to an optical coherence tomography scanner 3085. In some embodiments, the computer is connected to the word processor 3〇75. In the partial implementation queue - the 'server' includes a computer or at least a part thereof. A computer readable age (comput medium) may also include an instruction to perform the steps described herein. [0177] The system according to the above may include software for determining ophthalmic output and/or comparing measurements to other optical coherence tomography measurements (e.g., measurements previously taken from a patient or a baseline measurement). This soft palate can be at a remote location such as a device. The raw image data or the retrieved data can be transferred to a remote location such as a sputum where calculations and/or comparisons are performed. In some embodiments, the data corresponding to the previous test need not be sent to the optical shutdown scanning system, such as in the case of a remote location such as a ship. In some embodiments, the analysis is performed at both the optical coherence tomography instrument and the remote location, such as a servo. Therefore, appropriate software can be included in both the optical tonal tomography instrument and the remote location. [0178] The output may include a probability, for example, a probability of worsening or improving. The output can include a measure of confidence (c〇nfldenceme brewing e). For another example, the output can be pointed out - the ophthalmologic symptoms are bad, change # or remain roughly the same. The output can include a pre-application. For example, if it is determined based on the optical coherence tomography data that a special change has occurred or has exceeded the threshold, the output including the "scheduled towel" can be sent to - Jian

Kang care provider. The output may also include a suggested Q indicator for a referral or an appointment. [0179] In step 3025, the ophthalmic output is provided to a health care provider and/or the disease output, and the ophthalmic output can be output from an output device 31〇5, such as a transmitter 311 (eg, a '., line network) A transmitter (Wlreless netw〇rk), an electronic transmitter (dectr〇nic, a printer 3115, a telephone component 3i2〇, a display aid and/or a fax component 3130. The ophthalmic output can be stored in a storage component 3_ (eg, a dismounting storage tl piece), such as a disc or a brain drive (usBkey). In some cases, the storage element 3080 can be sent (directly or indirectly, such as through a user). To 62 201014571 Health,,, 'Guide to provider. Notifications may include - quantitative or fixed (four) one output of the 丨 variable. In some cases 'only if the symptoms may be worse, the symptoms may be improved and / Or when the ophthalmic output variable crosses the threshold, it will only be available to both the provider and the patient. In some cases, the ophthalmic output itself indicates that the optical coherence tomographer variable crosses 10. Readable pre-defined (eg The information contained in tfH5/ or a set of threshold variables associated with specific ophthalmic symptoms may be included in the ocular transection of the senile macular lesions, including o-center retina Thickness (central retinal), and == the determined thickness plus 100 micron (micron). The threshold and the door are placed in the -wei device. If super simple, health photo

ΐΓί Anti-vascular MM (antiHu_iaI growth f theory, secret veGF) secret re-treatment (time fine (4). Among the children, the ophthalmic loss (four) number itself is an indicator of whether the door sand is crossed. == For example By displaying the output, for example, the notification of the display - the patient's helper ^_科_. The output can also be printed by the printer 3ii5. The input = to be printed on paper or in the data storage device - On the surface. For example, the original can insert a card into the system. The system can read the card to identify the relevant information at a glance. Then the system can print the ophthalmology on the surface of the card, the patient is Instruct the card to be returned to the health care provider, for example L = phthal Γ (.phthalmologist), so that it can read the print · the exact order has been completed t date and the news will also follow the output - in some cases, only The date and time information is printed. In the part of the actual _ _ _ health care neck ° in the 'supplier's wheel includes the patient's name. Alternative program 疋 transmission can include 1 suffering, provide The code for the card of the patient. Therefore, in the 』 In the case of a health's care provider, the patient's privacy can be = send: yes - a third party rather than a health care provider (for example, by e-mail, the e-mail can be sent electronically to the e-mail In one case, the system 3〇5〇 is powered by 63 201014571 by means of a transmitter) to the Jianlai 2 printer 3115 for printing, and _ health care provider. In -J from the truth to the health care provider. The output can be passed to the . For example, the hif output is sent to the health care provider. For example, the system can include an automatic telephone component to the health care provider. In another example ==

^ Transmit (for example, by means of an output device) to the health care provider. Still in other embodiments, the towel 'f is sent by Sina (4), and the output is transmitted (for example, through the output device 3, the ship can be used, for example, to provide 5 ' The output can be provided on an internet site (for example, password protected). The health care provider can check the website by arbitrarily checking and/or sending a gamma (4) such as a phone call or an email message. In some cases, System 3 (4) has the ability to output the output in a number of ways, such as the axis described herein, and - the health care provider indicates the preferred output of the received output. New, by this better method, the output is transmitted to the health care provider.

Thus, in various embodiments the output includes many types of outputs. For example, the output may include a reservation request representing a disease detected by the instrument, a summary report, a single B-scan image, multiple B-scan images, or selected B-scan images, all of which are output to A health care provider, along with a confirmation of the scan and a different summary report, will all be output to the user. [0183] In step 3030, the ophthalmic data will be stored. The data can be stored in a storage element 3080. The storage element 3 〇 80 can be associated with an optical coherence tomography instrument 3 〇 85 and/or a remote location such as server 3075. In some cases, ophthalmic data includes raw optical tomosynthesis data. In some cases, ophthalmic data includes summary data, 64 201014571 such as the one ophthalmic output described here. The stored data can be associated with the patient (eg by using a patient identification symbol). [0184] The system 3050 described herein allows a user to monitor ophthalmic symptoms while traveling less frequently to a health care provider. Suffering from age-related macular degeneration, diabetic retinopathy, retinal vaso-occlusive disease, macular edema, macular hole, central ser〇 chorioretinopathy, retinal anterior membrane ( Epiretinal membranes, schisis cavities associated with optic disc pits, retinal inflammatory diseases, cataracts and/or glaucoma, especially for ophthalmic symptoms, especially System 3050 is used. Patients with dry age-related macular degeneration are advised to use an Amsler grid. The Amsler checklist is similar to the checkerboard, but one that suffers from age-related macular degeneration (ώίώ (1αίΐ1) may find that when looking at a point, the line appears wavy and some lines disappear No. So by comparing the grids that occur across time segments (time peri〇(J), patients may be able to estimate whether their disease is developing or improving. However, such testing is highly subjective. The use of system 3050 (especially for frequent use) can provide an alternative objective measure of a disease state, and a health care provider can determine a particular outcome that can lead to a recommendation to go to a health care provider again. [0185] Patients suffering from wet age-related macular degeneration may receive frequent, repeated anti-angiogenic factor therapy. The number and/or frequency of treatment may be based on the anatomical state of the patient's eye to Reduce the total number of medical treatments that must be taken at a given time. For example, 'if measured by optical coherence tomography Cardiac retinal thickness is increased by at least 100 microns. If new or increased cystic edema is detected, if subretinal fluid is present or if the size of pigment epithelial cell stripping increases substantially, it may be indicated that Treatment. By using the optical coherence tomography system 3050 described herein to monitor disease, patients can monitor disease characteristics frequently and conveniently, without the expense of their eye care provider. Responsible for medical treatment, and then book an appointment with a health care provider when new treatments are necessary or produce other 65 201014571 risk symptoms. [_ Treatments such as macular edema and glaucoma are supplemented with (aided) symptoms Frequent monitoring. This lying __ sweeping can be recorded, allowing more frequent monitoring and / or reducing the inconvenience caused to the silk and / or the bribe provider. In the case of glaucoma, the system can provide The dressing area (4) is used as an evaluation of the optic nerve and nerve fiber layers. [0187] In some embodiments, one or more data storage devices are provided. Cards (such as tape cards, smart cards, USB shirts). Data can be transferred by Mandard data transferring technique, such as by using a computer or a magnetic strip encoder and by waiting The development of data transmission and storage devices is transmitted to the device. The data storage device can be used to store information about an ophthalmologic condition, a patient and/or a health care provider. In the case, the device is provided from a health care provider. Information received by the health care provider or the health care provider. Information to be received from the health care provider may include patient identification information such as the patient's name or a patient identification symbol (eg, number). Information can indicate an ophthalmologic condition that the patient is suffering from or at risk. Information may refer to &quot;interest&apos; _eular _thalmic measurement (e.g., anterior chamber depth, macular volume, optic disc volume or nerve fiber layer volume) or a significant feature (concerning feature) ( For example, subretinal effusion, macular hole, retinal neovascularization, cystic space, pigment epithelial cell stripping). Information may indicate a current ophthalmic measurement and/or other criteria for a threshold or measurement. Doors can be absolute or opposite. Information can include information about health care providers such as their name, business, expertise 'associati〇n', address, email, fax number and/or phone number. Information can include information about the scan time. For example, the information may indicate that the patient will receive a scan within a time period or will receive a particular number of scans. In some cases, a system will compare the time zone on the device with the current time. If the current time is within the time zone, then only one optical coherence tomography scan is performed and 7 or only the device is accepted. The information may indicate a scan type (e.g., full or partial) or a scan characteristic (e.g., a resolution or region to be imaged). 66 201014571 A [0188] In some cases ητ, the data scale device is configured to be used repeatedly. For example, patients may be advised to follow a specific itinerary (for example, once a week for ten weeks, or every two weeks - until they reach - sweeping the fruit), and the patient can inspect for each scan. (scanvisit) uses the same card. In some cases, a software or a component (such as an electronic component or a fraud protection component) is used to determine whether the same county is reusing the card #, and the gift is deceived. ) Use this card. In this case, individual patterns, such as their retinal vessel pattern, can be compared at multiple visits to ensure that each time they are swept. To achieve this, other biometric measurements can also be developed or implemented. In some cases, prior to scanning the patient's eyes, the system is required to use a data storage device (e.g., a card) for a period of time specified on the data storage device. In some cases, data storage devices (such as cards) are configured to be used only once. The system can be used to accept the data storage device without returning it (confiscation) so that the patient cannot use it again. Alternatively, the system can change a portion of the data storage device (eg, a software component, data on the tape) such that the system does not accept the data storage device after a single use, after the data storage device is inserted after a single use No other scans will be performed. Multiple cards may be sent to a patient receiving a scan according to a particular itinerary (eg, ten weeks per week, or once every two weeks until a scan result is reached), and the patient may, for example, scan each scan Use a card when you use it. (It is worth noting that in some embodiments, a single sitting can provide multiple scans, such as investigating (inVestigate) multiple areas of the eye.) [0189] As described above, data storage devices (eg, The card) can include a writable surface. Therefore, the system can print a result on the data storage device. The result may include a conflation result that confirms (e. g., to a health care provider) that the scan has been performed. The confirmation result may include a period and/or a time. Results can include the results of an ophthalmic output or other scan. [0190] In a narrow-angle or angle-closure glaucoma, a block or drainage canaj block (〇bstnjcti〇n) can cause intraocular pressure 67 201014571 a chronic or acute increase. Such a barrier can occur when the iris pushes the lens of the eye. The iris and the crystal may even stick together. Narrow-angle glaucoma is highly prevalent in areas such as China and India. Therefore, it is advantageous to identify whether a patient is at risk of developing this condition. The depth of the anterior chamber may be associated with the development of narrow-angle glaucoma, which is generally shorter in patients with narrow-angle glaucoma than controls. See, for example, "Screening for naiT〇w angles in the Singapore population, evaluation of new noncontact screening methods", published in the Ophthalmology Journal published by Lavanya et al., May 15, 2008, the entire contents of which are incorporated herein by reference. For reference, this depth can be calculated from the distance between the posterior comeal surface and the anterior lens capsule. The anterior border of the anterior chamber depth can be the anterior comeral surface (anteriorcomealsurface) Or the interior of the corneal stroma (comealstroma). The posterior border of the anterior chamber depth can be replaced by a lens body. The thickness of the cornea (eg, a central corneal thickness) can also indicate whether a patient is suffering from a disease. There may be risks of glaucoma (eg, wide-angle glaucoma). The central corneal thickness can be measured at the distance between the anterior and posterior surfaces of the cornea at the center of the cornea. [0191] Thus a system disclosed herein (eg, System 1 〇〇, 3〇5〇) can be used to screen out glaucoma, for example Angle glaucoma and wide-angle glaucoma. Self-administered optical coherence tomography tests can be performed on patients with or without glaucoma diagnosed. System 100, 3050 can indicate that the patient is suffering from a glaucoma symptom and has an episode风险 The risk of a glaucoma symptom or an indicator of the severity or condition of the condition. [〇m] System: L〇0, 3〇5〇 can, for example, measure the anterior chamber depth or corneal thickness of a user, and A comparison of this depth to the depth or thickness of a threshold to determine if the user is suffering from or suffering from a glaucoma symptom. If the depth or thickness exceeds a threshold or other criteria, the output indicates that the output can be used accordingly. / or - health care provider. The output may indicate the measured depth or thickness, may indicate that the measured data is within a specific range, may indicate that the measured data exceeds a threshold or other criteria and/or may indicate the user Positive suffering - glaucoma symptoms or optic nerve disease (〇ptic n (four) this) * 68 201014571 a chance. Other rounds It may also be provided. It is worth noting that in some cases, "over-doorcast" includes being greater than the gate right' and in other cases including less than the gatecast. For example, in the case of narrow-angle glaucoma, a smaller anterior chamber depth is associated with symptoms, so exceeding the threshold can mean that the measured depth is less than the threshold. A threshold may include about 35 mm, 3.3 mm, 3_1 mm, 3·〇 mm, 2·9 mm, 28 mm, 2 7 mm, 26 mm, 2.5 mm, 2.4 mm, 2.3 mm, 2.2 mm, 2.1 mm. 2. A anterior chamber depth of 〇 mm, 15 mm or 1, 〇 mm. It is worth noting that the threshold value balances sensitivity and specificity, which makes it easier for some thresholds to detect all events of a disease, but it is also easier to include false detections (falsep〇sitive). Other thresholds are easy to miss the real event of the disease, but will also involve less misdetection. Based on how far a measurement exceeds a threshold or measures that exceeds most thresholds, the output can indicate a probability that the patient is suffering from a disease. However, among various embodiments, a risk assessment will be provided. [0193] An optical coherence tomography measurement can indicate a risk of suffering from a symptom. In some cases, an association between the measurement and a probability of having symptoms can be established (e.g., a monotonic relationship). This relationship can be established based on empirical data (empirical data). As a result, measurements can be converted to odds or risk of disease. In some cases, an association between the measurement and the probability of having symptoms later can be established so that a preventive measure can be taken to reduce this chance. In some cases, some measurement ranges can be established, each range being associated with a (current or future) symptomatic probability. [0194] In many embodiments, the system 1A, 3050 can, for example, measure the anterior chamber depth or a corneal thickness of a user, and the depth can be compared to a previously measured depth or thickness. Whether the symptoms are improving or worsening. Previously measured data can be loaded from a storage component. The output can indicate that the symptoms are improving, worsening, or roughly the same. The output can quantify a change in a symptom-related measurement. The output can indicate if the change exceeds a threshold. [0195] In some cases, the front side of the eye is imaged by proper positioning of the z-axis offset adjustment stage 290 69 201014571. In some cases, the quality of the scan determines, at least in part, which structural anatomical structures are used to define the boundaries of the anterior chamber distance. When the quality is high, the posterior surface of the cornea and the anterior lens surface can be regarded as the anterior and posterior borders respectively. However, when the quality is low, the corneal stroma can be replaced as the anterior border and/or the hydrometeor body can be Replaced as the back side boundary. [0196] In some cases, an a-scan can be used to determine a thickness or depth. However, the depth or thickness may depend on a radial position of the scan. Thus, a B scan or a set of A scans can be obtained and a first thickness or depth can be determined for each A scan. The maximum thickness or depth or a particular distance from the central axis of the eye can be determined as a useful thickness or depth for comparison or as an output. [0197] The optical coherence tomography system can position a z-axis offset adjustment platform 290 to adjust the portion of the eye that is imaged' and then the adjustable optical device 21() can focus the beam such that a small area of the feature can be Clearly imaged. For some applications of optical tomographic scanning, it is desirable to have a scan through a small area of the eye (e.g., about one axis, about two millimeters). Instruments designed especially for smaller areas are capable of imaging areas with higher resolution. However, limiting the extent of the scan to such a short depth may hinder the capture of the important - entire area. For example, with a depth of 22 mm, an A-scan of distance to distance may be too small to include both the front and back borders of the anterior chamber in the A-scan. In the case, a larger a-scan can be obtained (for example, a distance of more than about 3 or 4 mm in the Z direction) so that both the front and back boundaries of the (four) domain can be configured in some cases to make all Scanning extends to cover the degree of comparison. In some cases, the New Zealand is configured to have money—a specific area (for example, a side section) that rides the casting extension to a shorter range, and thus, the area. In some cases, the system is configured such that a particular scan can be extended to cover - longer or - shorter depths. In some cases, it can be obtained - the longer of the area [ug] in the other - example, get multiple scans, each scan at - different depths 201014571 • lines. For example, the first scan can adjust at least the optical element to image the front side boundary of an area, and a second scan can adjust at least one element to image at a back side boundary. For example, the 'Z-axis offset adjustment platform 290 and the adjustable optical device can be positioned such that the posterior corneal surface is imaged and an _A scan can be obtained. The z-axis offset adjustment platform 290 and the adjustable optical fixture 210 can then be positioned/imaged to the front side of the crystal and another A-scan can be obtained. The distance between the features on the structure can be determined based on the combination of different locations of the features within the A-scan and different positions of the Z-axis offset adjustment platform. [0199] In some cases, multiple A-scans may be obtained by imaging the width of the selected (four) copies or the anterior chamber, which may be - a substantial portion of the width or the entire width. In these cases, the peripheral chamber depth, angle ge〇metfy, and/or angular structure can be determined. These measurements can be used to determine whether a patient is suffering from a condition (such as a narrow-angle glaucoma), a risk of developing a condition, or an indication of the severity or condition of the condition. [0200] Other variations are also possible. For example, because the central corneal thickness can also have some predictive value (and can be calculated from the distance between the anterior and posterior surfaces of the cornea), this measurement may also be used to screen for wide-angle glaucoma. [0201] All of the above methods and programs can be implemented and fully automated via one or more general purpose computers (software code modules) executed by a processor or a processor. The encoding module can be stored in any type of computer. The media can be captured or misplaced on other computers. Some or all of the methods can also be implemented with specialized computer hardware. [0202] While the invention has been discussed in terms of certain embodiments, it should be understood that the invention is not limited. The embodiments herein are explained by way of example, and many modifications, variations and other embodiments may be employed, which are still within the scope of the invention. Elements can be added, removed, and/or reassembled. In addition, processing steps can be added, removed, or reordered. Xu • Many different designs and methods are also available. 71 201014571 [0203] In order to achieve the above-described effects, several aspects, advantages, and novel features of the present invention are described herein. It will be understood that all of the above advantages are not necessarily required to be implemented in accordance with a particular embodiment of the invention. Thus, for example, those skilled in the art will recognize that the present invention may be implemented in a manner that achieves one or more of the advantages disclosed herein, but does not necessarily achieve other advantages as taught or suggested herein. . BRIEF DESCRIPTION OF THE DRAWINGS [0010] The above-described or other features, aspects, and advantages of the present invention are set forth in the accompanying drawings, 0 is used to limit the invention. The drawings of the present invention include: [0011] Figure 1 is a schematic illustration of an embodiment of an optical coherence tomography system of the present invention. [0012] FIG. 2 is a schematic illustration of an embodiment of an interferometer for performing measurements of an eye. 3A is a schematic diagram of an embodiment of an optical coherence tomography system that includes a body for facilitating contact with a person's eyes, the body being in communication with various systems of the present invention (FIG. 3A). In communication with). [0014] FIG. 3B schematically depicts a perspective view of one embodiment of the body shown in FIG. 3A. [0015] FIG. 4 is a schematic diagram of an embodiment of a spectrometer for analyzing data from an interferometer for optical coherence tomography. [0016] FIG. 5 is a schematic illustration of the body of an optical coherence tomography system including a single display for displaying a display target for a patient/object. 6A to 6C are schematic diagrams showing the use of optical coherence tomography to scan retinal tissue to produce A-scan and B-scan. 72 201014571 [0018] FIGS. 7A through 7F illustrate schematic diagrams of embodiments of adjusting and/or correcting pupil distance. [0019] FIG. 8 is a block diagram schematically showing an embodiment of a computer system of an optical coherence tomography system according to the present invention. [0020] FIG. 9 depicts a flow diagram of an embodiment of accurately measuring retinal tissue to detect a particular disease condition. [0021] Figures 10A through 10D illustrate possible embodiments of a body of an optical coherence tomography device disposed relative to a user. [0022] FIGS. 11A-11B illustrate possible embodiments of an output report generated by an optical coherence tomography device. [0023] FIG. 12 is a block diagram schematically showing another embodiment of a computer system of an optical coherence tomography system according to the present invention. [0024] FIG. 13 is a block diagram schematically showing elements of an embodiment of a computer system of an optical coherence tomography system according to the present invention. [0025] FIG. 14A schematically depicts a diagram of an embodiment of determining a risk assessment. 14B is a schematic diagram showing the relative relationship between retinal diseases and retinal film thickness for determining risk assessment in another embodiment. 15 is a schematic diagram showing the detection of retinal pigment epithelial cells and the polynomial fit curvature of the retinal pigment epithelial cells and the difference therebetween. [0028] Figure 16 is a schematic illustration of the division of retinal tissue into regions of the inner and outer retinal tissue. 17A to 17C show B-scans obtained when the optical coherence tomography system is located at a position that is too _, (10), or evasive. [0030] FIGS. 18A to 18C show that when the optical coherence tomography system is located too far ahead, after providing an increased field of view or after recording (4), the intersection of the light traces will be after the pupil, in the pupil plane or Before the pupil. 73 201014571 [0031] Figure 19 shows an embodiment of an appropriate working distance between an optical coherence tomography system and a target/patient's retinal membrane. [0032] Figure 20 shows a procedure for monitoring an ophthalmic condition using an optical coherence tomography system. [0033] FIG. 21 is a block diagram of an embodiment of an optical coherence tomography system including an input device and an output device for monitoring an ophthalmic condition. [Main component symbol description] 100, 3050: System 102, 3105: Output device 104: Computer system 106: Main body 108: Communication medium 110: Remote system 112: User card reading system 114: User 116: Zero gravity arm 118: handle 120: eyepiece cup 150, 207, 405: light 155, 240: light source 160, 220a, 220b, 230a, 230b, 245, 285a, 285b, 295a, 295b: beam splitter 165, 600: eye

74 201014571 170, 265a, 265b, 270a, 270b, 273a, 273b: reference mirror 202: data acquisition device 203: eyepiece 235: adjustment controller 205: optical component 210: optical device 215, 215a, 215b, 3125: display 225a , 225b, 250a, 250b, 255a, 255b, 260a, 260b, 510a, φ 510b: mirror 275: switch 280: beam deflector 290a, 290b: adjustment platform 400: spectrometer 410: collecting lens 415: slit ^ 420 : Collimating lens ❹ 425 : grating 430 : focusing lens 505 : X 稜鏡 605 : horizontal direction 610 : scanning trajectory ' 715 , 715a , 715b : gazing target * 802 : user / patient database 75 201014571 804 : physician turn Library 805: User Interface Module 806: Reporting/Output Module 808: Disease Risk Assessment/Diagnostic Module 810: Billing Module 812: Network Interface 814: Firewall 816: Authentication Module 818: Z-Axis Positioning Module 820: focus adjustment module 822: gaze mark control system 824: scan control and analysis module 826: image/scan database 828: underwriting database 9 (U, 902, 904, 906, 908, 910, 912, 913, 914, 915, 916, 917, 918, 919, 920: Block 1005: Band 1010: Object 1201: Billing/Insurance Reporting and Payment System 1300: Computing System 1301: Mass Storage Device 1302: Multimedia Device 1303: Input/Output Device and Interface 201014571 ❹ 1304: Central Processing Unit 1305: Memory 1306: Image Processing and Analysis Module 1310: Network 1315: Communication Line 1317: Remote System 1319: Source 1502: Retinal Pigment Epithelial Cell Layer 1504: Retinal Pigment Epithelial Cell Layer Curve 1506: Difference/Value 1602: Within Half 1604 : Outer half 1606 : Inner limiting membrane detection 1608 : Retinal pigment epithelial cell detection line 2005a, 2005b, 2020a, 2020b : Beam 2010 · · Rotation point 2015 : Area 2025 : Iris 2030 : Pupil 2105 : Working distance 2110: Retina 3000: Programs 3005, 3010, 3015, 3020, 3025, 3030 · Step 77 201014571 3055: Input device 3060: Receiver 3065: Card reader 3070: USB drive reader 3075: Server 3080: Storage element 3085: Instrument 3090: Interferometer

3095 : Detector 3100 : Electronic device 3110 : Transmitter 3115 : Printer 3120 : Telephone component 3130 : Facsimile component

78

Claims (1)

201014571 VII. Scope of application for patents: 1. - Optical closure of chronic eye diseases and supervision system, including: An optical coherence tomography measuring device for measuring at least one eye of at least one eye of a user 'Campus _ riding the remuneration device (4) to enable the user to self-manage the measurement behavior using the device; a processor for comparing the measured ophthalmic characteristics with at least the pen stored in a storage medium According to the previously measured ophthalmic characteristics, the processor further determines (10) that the amount of mosquitoes to Weicoza and the difference of the previous _amount of ophthalmic characteristics is different when the difference satisfies at least the standard, the processor rib determines the need An increased probability of treatment; and a round-out device that generates and transports the user, the processor further for generating the output on the output device based on the difference. 2. 3. 4. 5. 6. If the system of request 1 is 'in which the discretion depends on at least the standard, the processor proceeds to determine that no additional eye monitoring is required. A person, as claimed in claim 1, further comprising a card reading device for accommodating the system for storing the ==2_age_card device, storing the previously determined device claim i, wherein the storing The medium is - please use the previously measured ophthalmic characteristics. The system of claim 4, wherein the system includes the database. The system of claim 4, which is located at the remote location of the system. The system of claim 1, wherein the output device is a display device capable of satisfying the at least one criterion, the display device is configured to suggest a difference in the field, and when the difference is full; The display device is used by the user at 79 201014571 for at least _ standard time. 8. The system of claim 1, wherein the output device is a communication interface, and when the difference satisfies the at least one criterion, the communication interface is used to notify the user of the medical treatment. The system of claim 8, wherein the processor is for acknowledging from the _user card device, the physician's liaison, and the communication interface notifying the physician using the contact information. 10. The system of claim 1, wherein the at least one criterion comprises a set of criteria. 11_ The system of claim 1, wherein the at least - ophthalmic characteristic is _# cardiac retinal thickness. I2. The secret of claim 1, wherein the processor identifies the user by at least one of the biometric measurements of the (4). 13. A self-management-optical tonal tomography test behavior method for monitoring an ophthalmic condition, the method comprising: receiving information about the ophthalmic symptom; using an optical coherence tomography instrument to obtain at least one user's eye Coherent tomography measurement; according to the optical coherence tomography _ Quantitative mosquito-ophthalmology output, the ophthalmic output is related to a state of the ophthalmic symptom; and outputting the ophthalmology recording, the health bribe provider and the health care provider At least one of the agencies of the person. 14. The method of claim 13, wherein the step of receiving information about the ophthalmic symptom comprises receiving information about the ophthalmic symptom from the user. 15. The method of claim 13, wherein the step of receiving information about the symptoms of the eyelid comprises receiving a data storage device that stores relevant information about the ophthalmic symptom. 16. The method of claim 15, wherein the data storage device comprises at least one of a card, a smart card, and a ten thousand serial bus device. The method of claim 15, further comprising authorizing the user to perform signal transmission according to the data storage device. 18. The method of claim 13, wherein the step of receiving information about the ophthalmic symptom comprises receiving information about the ophthalmic symptom in an electronic transmission. 19. The method of claim 13 wherein the step of receiving information relating to the ophthalmic symptom comprises receiving information about the ophthalmic symptom via wireless transmission over a network. 20. The method of claim 13, wherein the information comprises an identification of the ophthalmic condition. 21. The method of claim 13, wherein the information comprises the user being suffering from the ophthalmologic disease. 22. The method of claim 13, wherein the information comprises a severity measure (with a measure), the severity The measurement is related to a quantification of the user in a state of the previous ophthalmic condition. 23. The method of claim 13 wherein the information includes a standard associated with the ophthalmic output and the step of outputting the ophthalmic output comprises outputting the ophthalmic condition when the criterion is met. 24. The method of claim 13 wherein the ophthalmic round includes a recommendation that the user consults the health care provider. 25. The method of claim 1 wherein the ophthalmology rotates a finger that contains the ophthalmic symptom that exceeds a threshold of a worse than expected state. 27. If the method is ascertained = 3 method' wherein the ophthalmic wheel* contains an indicator that the state is improved compared to an expected state. 28. The method of claim 13, wherein the ophthalmic rim that exceeds a better than expected state comprises an indicator of the threshold value of the state of the neon symptom. 201014571 29. The method of claim 13, wherein the ophthalmic output comprises at least one of: a corneal thickness, a corneal shape, a anterior chamber depth, an angle opening distance, a crystallite thickness, a The intensity of the crystal, the amount of vitreous cells, the thickness of a retina, the volume of a retina, the thickness of a drusen, the thickness of a retinal pigment epithelial cell, the volume of a drusen, the volume of a retinal pigment epithelial cell, the depth of a macular fluid, a macular fluid volume, a mtraretinal hyperreflectivity volume, a number of intraretinal hyperreflective structures present, an intraretinal hyporeflective volume, The number of low-reflective structures in the retina (number 〇f ώίΓ3Γβώι&amp;1 hypOTeflectiyity structures present), the volume of a optic nerve cup (〇ptic cup Μ·), the thickness of a retinal nerve fiber layer, the volume of the retinal nerve fiber layer, A choroidal thickness and a choroidal volume (ch〇roidalvQlume) e. The method of claim 13, wherein the step of outputting the ophthalmic output comprises advising the user to consult a health care provider. 31. The method of claim I3, wherein the step of ejecting the ophthalmic wheel (four) comprises delivering the ophthalmology output to the age provider or the lender to provide the agency. The method of claim 31 is transmitted in a round-trip manner. The step of transmitting the ophthalmic output includes electronically transmitting 33. as described in claim 31, transmitting. The step of transmitting the ophthalmic rotation includes the recording of the ophthalmic output via a network 34. 35. 36. The method of clarifying the item __ the step includes the method described in the method of transmitting the ophthalmic output. The method of transmitting the postal item, wherein the method of claim 13 is as follows: the method of claim 13 wherein the step of outputting the ophthalmic rotation comprises displaying the ophthalmic output to the user using the 2010 2010. 38. The method of claim 13 wherein the step of outputting the ophthalmic output comprises printing the ophthalmic output. 39. The method of claim 13 further comprising storing the ophthalmic output. 40. The method of claim 13 wherein the step of obtaining an optical tonal tomographic measurement comprises obtaining an optical coherence tomography measurement according to a pre-determined or physician-prescribed stroke. 41. The method of claim 13, further comprising analyzing a biometric character of the user to verify a proof of the user. The method of claim 13, wherein the ophthalmic symptom comprises at least one of the following: corneal edema, comeal astigmatism, dry eyes, narrow-angle glaucoma, anterior segmental vibritis 'Middle uveitis, postoperative follow-up, dry aged macular degeneration, wet aged macular degeneration, macular edema, macular chorionic retinopathy of the macular hole, retinal anterior membrane, rupture cavity and optic disc hole, Retinal inflammatory disease and wide-angle glaucoma. 43. The method of claim 13, further comprising: determining a plurality of fields of view of the optical coherence tomography instrument, wherein each of the fields of view is by a plurality of locations of an optical component of the optical tomography scanner Determining; comparing at least two of the fields of view; and locating the optical component based on the results of comparing the defects. 44. An optical coherence tomography system comprising: - an input device for receiving - information about ophthalmic symptoms; an eyepiece for receiving at least one eye of a user; - a light source 'transmitting through the eyepiece Light to the eye of the person; - the interferometer's rib causes optical drying by light reflected from the user's eyes; an optical detector arranged to detect the optical interference; an electronic device 'connected To the optical detector, and for analyzing a plurality of optical coherence tomography measurements obtained by the interferometer, and determining an ophthalmic output associated with a state of the ophthalmic output; and an output device being electrically connected To the electronic device, the output device is configured to output the ophthalmic output. 45. The system of claim 44, wherein the input device is configured to receive information about the ophthalmic symptom from the user. The system of claim 44, wherein the input device is configured to receive a data storage device that stores relevant information about the ophthalmic condition. 47. The system of claim 46, wherein the data storage device comprises at least one of a card, a smart card, and a ten thousand serial bus device. The system of claim 46, wherein the data storage device comprises a card reading device. The system of claim 44, wherein the input device comprises an electronic receiver. The system of claim 44, wherein the wheeling device comprises a wireless network receiver. 51. The system of claim 44, wherein the information comprises a determination of the ophthalmic condition. 52. The system of claim 44, wherein the information comprises a finger of the user who is suffering from the makeup. 53. The system of claim 44, wherein the information includes a severity measure, a degree measure, and the (4) person is in the form of a request to quantify the phase. 54. The system of claim 44 And wherein the information includes the ophthalmology and when the ophthalmology exceeds the threshold, the rounding device is configured to output the word 55. The system of claim 44, wherein the ophthalmic output comprises the user consulting a health 84 201014571 A suggestion for care providers. The system of claim 44, wherein the ophthalmology rotates an indicator that the state of the ophthalmic condition is worse than an expected state. 57. The system of claim 44, wherein the ophthalmic output comprises an indicator that the state of the ophthalmic condition exceeds a threshold value that is worse than an expected state. 58. The system of claim 44, wherein the ophthalmic output comprises an indicator that the state of the ophthalmic condition is improved over an expected state. 59. The system of claim 44, wherein the ophthalmic output comprises an indicator that the state of the ophthalmic condition exceeds a threshold value that is greater than an expected state improvement. 60. The system of claim 44, wherein the ophthalmic round comprises at least one of: - corneal thickness, - corneal shape, - anterior chamber depth, angle opening distance, monocrystalline thickness, monocrystalline intensity, The number of vitreous cells, the thickness of a retina, the volume of a retina, the thickness of the glass membrane, the thickness of the retinal pigment epithelial cells, the volume of a drusen, the volume of a retinal pigment epithelial cell, the depth of a macula, and the yellow spot. Fluid volume, high reflex volume in the retina, high reflexivity in the retina, f quantity... low reflex volume in the retina... existing retinal low-reflective structure, optic nerve cup, retinal nerve fiber layer Thickness, a retinal nerve Q fiber layer hoarding, a choroidal thickness, and a choroid effusion. The system of claim 44, wherein the output device is operative to instruct the user to consult a health care provider. 62. The secret of claim 44, wherein the output device comprises an electronic transmitter. The system of claim 44, wherein the output device comprises a wireless network transmitter. The system of claim 1, wherein the rounding device includes the agency for outputting the ophthalmic output*, a health care provider, or a health care provider. The system of claim 44, wherein the output device comprises a display. The system of claim 44, wherein the output device comprises a printer. 85. The system of claim 44, further comprising a memory for storing the ophthalmic rotation. 68. The system of claim 44, wherein the ophthalmic symptom comprises at least one of the following: horn edema, corneal astigmatism, dry eye, narrow-angle glaucoma, anterior uveitis, mid-section uveitis, surgery Post-tracking, dry age-related macular degeneration, wet age-related macular degeneration, macular edema, macular hole, central serous chorioretinopathy, anterior retinal palpebral palpebral ventricle, optic disc, retinal inflammatory disease, and wide angle Glaucoma. 69. A self-managing optical coherence tomography system for gamma glaucoma, the system comprising: - an optical coherence tomography measuring device for obtaining a first set of optical coherence of a first region of the user's eye Fault _ data, and a second zone of the eye a second set of optical coherence tomography data of the domain, the regions of the eye being at different rear side depths, the optical coherence tomography device for causing the user to self-administer the scanning behavior using the device; 'The ribs enable the group-optical tonal tomographic data to determine a first-boundary position' and use the second set of optical coherence tomographic data to determine a second boundary position, the processor depending on the first boundary position And the second boundary position determines an eye distance 'where the processor is further used to compare the eye distance and the threshold value to screen the glaucoma in the eye; and the output device 'is used to compare the eye distance with The result of the threshold is a round out on the light-out device. The optical tomographic scanning method according to claim 69, wherein the optical same-offwidth scanning scanning device further comprises a -z axis offset adjusting platform, and the optical same layer scanning scanning Positioning the axis offset adjustment platform to obtain the first group and the second group of light guide coherent tomographic data. The optical coherence tomography system described in the above, wherein the optical homology is widely adjusted to an optical device, and the optical coherence tomography scans the optically adjustable optical gyro-group and the second optical coherence tomography data. 86 71 201014571 • 72·==The optical coherence tomography system, the distance of the shirt is - the front eye (four) depth is the boundary of the second boundary - L1:: and ? 74 + ======w Yes - angle 75+, fine boundary is a water e 76. = two tomography system, the output device is used to output a risk assessment of the user's possibility of developing a narrow-angle glaucoma in the eye. 77. In the optical coherence tomography system of claim 76, the bottle risk is assessed as a high test. The surface is less than 78. The optical coherence tomography system of claim 76, wherein the risk is assessed to be low risk when the threshold is thresholded. The optical homology tomography system of claim 73, wherein the eye of the user has a narrow-angle glaucoma assessment. w Clinical sf 1 stone 80. The optical coherence tomography system of claim 79, wherein when the threshold (10), the bed evaluation is in the narrow angle treasury (four) fixed scale ^ depth seven, SL as claimed in claim 79 An optical coherence tomography system wherein the clinical assessment is negative for narrow-angle glaucoma when the threshold is reached. 82. The optical coherence tomography system of claim 69, wherein the anterior chamber depth or angle geometry. The optical coherence tomography system of claim 82, wherein the optical stereotype of the user is as follows: 87 201014571 84. Optical coherence tomography as described in claim 69 A system wherein the anterior chamber depth is a measure of a corner thickness of a cornea of the eye of the user. 85. The optical coherence tomography button of claim 84, wherein the thickness of the membrane is to treat a anterior surface of the cornea as the first boundary position, and the surface of the horn is regarded as the second boundary position and measure The distance between the anterior surface of the cornea and the sacral side surface, wherein the thickness of the cornea measures the center of the cornea. 86. The optical coherence tomography system of claim 85, wherein the output device is operative to output a risk assessment of the likelihood of wide-angle glaucoma in the eye of the user. 8. The optical coherence tomography system of claim 86, wherein the risk is assessed to be a high risk when the corneal thickness is below the threshold. The optical coherence tomography system of claim 86, wherein the risk is assessed to be low risk when the corner media thickness is above the threshold. 89. The optical coherence tomography system, wherein the output device is used to transmit (4) a clinical evaluation of the possibility of wide-angle glaucoma in a user's Wei eye. 0 optical with the touch layer scanning secret, its +# when the corneal thickness is lower than the threshold value, the fine bed evaluation (10) Yu Guang - #光_ is positive. 91. The optical coherence tomography described in claim 89, At the threshold, the clinical evaluation of the judgment for wide-angle glaucoma 92. The optical coherence tomography as described in claim 69 is a condition of glaucoma that is more comparable than the eye-clearing axis-first singer. The value of the quantity 'is determined in the eye of the user A :===: learning _ tomography system' where the output device is more tuned with A ==: This == _ eye provides self-management optics using an optical coherence a tomographic instrument for obtaining an optical tonal tomographic measurement of at least one user's anterior segment 88 201014571; the ophthalmic rotation and the measurement according to the optical coherence tomography determining an ophthalmic rotation, a glaucoma state correlation; and an output The ophthalmology is output to at least one of the user, an agent of the donor. A method of claim 94, wherein the glaucoma comprises a wide-angle glaucoma. The method of claim 94, wherein the glaucoma comprises a narrow-angle glaucoma. 97. The method of claim 94, wherein the step of determining the ophthalmic rotation comprises identifying a distance between a front side boundary and a back side boundary. 98. The method of claim 94, wherein the step of the mosquito training (IV) comprises identifying a distance between a front side boundary and a back side boundary of an anterior chamber of the user's eye. 99. The method of claim 98, wherein the anterior border comprises at least one of a posterior surface of the cornea and a corneal stroma. The method of claim 98, wherein the backside boundary comprises at least one of a body of a crystal. The method of claim 94, wherein the step of obtaining the optical tomographic measurement comprises obtaining a plurality of optical tonal tomographic measurements, wherein the positions of the optical orthospheric scan measurements are located at a different radial position. And the step of determining the rotation of the ophthalmology comprises: according to the distance on each fine structure (^^ (4) ee); and identifying the maximum value of the distance commands on the structures. 102. The method of claim 94, wherein the step of determining the simplification comprises: ???the first-group optical coherence tomography data of the first-region--the second set of optical coherence tomography data, The Μ2 &amp; field of the eye is located at different anteroposterior depths; 89 201014571 using the first set of optical _ tomographic data to determine the -th boundary position; using the second set of optical coherence tomography data to scan the mosquito - second boundary position And determining the eye distance based on the first boundary position and the second boundary position. 1〇3_ The method of claim 94, further comprising receiving information about the glaucoma. The method of claim (10) = wherein the step of accepting the related information of the glaucoma comprises accepting - a data storage device storing the information of the glaucoma. The method of claim 10, wherein the method comprises the glaucoma mode, wherein the information is as described in claim 10, wherein the information includes the #纲目, and outputs the miscellaneous reading (4) The method includes the method of claim 94, wherein the ophthalmic wheel contains a probability that the person is experiencing discomfort due to glaucoma if the (4) silk exceeds the distance. The method of claim 94, wherein the ophthalmic wheel contains a probability that the user is uncomfortable to touch the glaucoma. The method of claim 94, wherein the ophthalmic wheel contains an indicator of glaucoma. 110. The method of claim 94, wherein the ophthalmic output comprises an indicator that the condition of the glaucoma is worse than an expected state. 111. The method of claim 94, wherein the ophthalmic round includes the glaucoma The state of the present invention exceeds an indication of a homing value that is worse than the expected state. The method of claim 94, wherein the ophthalmic rotation includes an indicator that the state of the glaucoma is improved over an expected state. 13. The method of claim 94, wherein the ophthalmic subject rotates an indicator that the state of the glaucoma exceeds a threshold of improvement over a desired state. 114. The method of claim 94 The step of outputting the ophthalmology comprises suggesting that the user of the 201014571 be contacted with the health care provider. The method of claim 94, wherein the step of outputting the ophthalmic output comprises transmitting the ophthalmic output to the health care provider or The agency of the health care provider. 91