TR202018841A2 - Uzun zi̇nci̇rli̇ mono ve di̇gli̇seri̇t karişimlari i̇le hazirlanan bosentan monohi̇drat yüklü kendi̇li̇ği̇nden nanoemülsi̇fi̇ye i̇laç taşiyici si̇stemleri̇n (snedds) formülasyonu - Google Patents
Uzun zi̇nci̇rli̇ mono ve di̇gli̇seri̇t karişimlari i̇le hazirlanan bosentan monohi̇drat yüklü kendi̇li̇ği̇nden nanoemülsi̇fi̇ye i̇laç taşiyici si̇stemleri̇n (snedds) formülasyonuInfo
- Publication number
- TR202018841A2 TR202018841A2 TR2020/18841A TR202018841A TR202018841A2 TR 202018841 A2 TR202018841 A2 TR 202018841A2 TR 2020/18841 A TR2020/18841 A TR 2020/18841A TR 202018841 A TR202018841 A TR 202018841A TR 202018841 A2 TR202018841 A2 TR 202018841A2
- Authority
- TR
- Turkey
- Prior art keywords
- snedds
- formulation
- prepared
- long
- polyoxyl
- Prior art date
Links
- GJPICJJJRGTNOD-UHFFFAOYSA-N bosentan Chemical compound COC1=CC=CC=C1OC(C(=NC(=N1)C=2N=CC=CN=2)OCCO)=C1NS(=O)(=O)C1=CC=C(C(C)(C)C)C=C1 GJPICJJJRGTNOD-UHFFFAOYSA-N 0.000 title abstract 4
- 229940036810 bosentan monohydrate Drugs 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000003937 drug carrier Substances 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 abstract 3
- 125000005456 glyceride group Chemical group 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- WECGLUPZRHILCT-GSNKCQISSA-N 1-linoleoyl-sn-glycerol Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@@H](O)CO WECGLUPZRHILCT-GSNKCQISSA-N 0.000 abstract 1
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 abstract 1
- 239000000263 2,3-dihydroxypropyl (Z)-octadec-9-enoate Substances 0.000 abstract 1
- RZRNAYUHWVFMIP-GDCKJWNLSA-N 3-oleoyl-sn-glycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-GDCKJWNLSA-N 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 abstract 1
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 abstract 1
- 238000005457 optimization Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000004448 titration Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Buluş, uzun zincirli mono ve digliserit karışımları kullanılarak bosentan monohidrat (BOS) içeren sıvı kendiliğinden nanoemülsifiye ilaç taşıyıcı sistemlerin (SNEDDS) formülasyonlarının hazırlanması, optimizasyonu ve karakterizasyonları ile ilgilidir. BOS içeren sıvı SNEDDS, Gliseril monolinoleat (Maisine®) - Polioksil 40 hidrojene hint yağı (Cremophor®RH 40) - Kaprilokaproil polioksil-8 gliseritleri (Labrasol®) ve Gliseril monooleat (Peceol®) - Polioksil 40 hidrojene hint yağı (Cremophor®RH 40) - Kaprilokaproil polioksil-8 gliseritleri (Labrasol®)’nin belirli oranlarından oluşmuş ve sistemler su ile titrasyon yöntemi ile belirlenmiştir.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2020/18841A TR202018841A2 (tr) | 2020-11-23 | 2020-11-23 | Uzun zi̇nci̇rli̇ mono ve di̇gli̇seri̇t karişimlari i̇le hazirlanan bosentan monohi̇drat yüklü kendi̇li̇ği̇nden nanoemülsi̇fi̇ye i̇laç taşiyici si̇stemleri̇n (snedds) formülasyonu |
| EP21895278.6A EP4221689A4 (en) | 2020-11-23 | 2021-11-22 | FORMULATIONS OF BOSENTAN MONOHYDRATE-LOADED SELF-ANOEMULGATING ACTIVE INGREDIENT RELEASE SYSTEMS (SEDDS) WITH LONG-CHAIN MONO- AND DIGLYCERIDE MIXTURES |
| PCT/TR2021/051258 WO2022108572A1 (en) | 2020-11-23 | 2021-11-22 | Formulations of bosentan monohydrate loaded self-nanoemulsifying drug delivery systems (snedds) prepared with long-chain mono and diglyceride mixtures |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2020/18841A TR202018841A2 (tr) | 2020-11-23 | 2020-11-23 | Uzun zi̇nci̇rli̇ mono ve di̇gli̇seri̇t karişimlari i̇le hazirlanan bosentan monohi̇drat yüklü kendi̇li̇ği̇nden nanoemülsi̇fi̇ye i̇laç taşiyici si̇stemleri̇n (snedds) formülasyonu |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR202018841A2 true TR202018841A2 (tr) | 2021-01-21 |
Family
ID=75576062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2020/18841A TR202018841A2 (tr) | 2020-11-23 | 2020-11-23 | Uzun zi̇nci̇rli̇ mono ve di̇gli̇seri̇t karişimlari i̇le hazirlanan bosentan monohi̇drat yüklü kendi̇li̇ği̇nden nanoemülsi̇fi̇ye i̇laç taşiyici si̇stemleri̇n (snedds) formülasyonu |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP4221689A4 (tr) |
| TR (1) | TR202018841A2 (tr) |
| WO (1) | WO2022108572A1 (tr) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2240470A4 (en) * | 2008-01-10 | 2012-05-23 | Msn Lab Ltd | IMPROVED AND NEW PROCESS FOR THE PREPARATION OF BOSENTAN |
| KR101058860B1 (ko) * | 2008-10-20 | 2011-08-23 | 조선대학교산학협력단 | 수소화 코코-글리세라이드를 이용한 난용성 약물의 자가유화형 나노에멀젼 조성물 |
| WO2012139736A1 (en) * | 2011-04-11 | 2012-10-18 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Pharmaceutical composition comprising bosentan |
-
2020
- 2020-11-23 TR TR2020/18841A patent/TR202018841A2/tr unknown
-
2021
- 2021-11-22 EP EP21895278.6A patent/EP4221689A4/en active Pending
- 2021-11-22 WO PCT/TR2021/051258 patent/WO2022108572A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022108572A1 (en) | 2022-05-27 |
| EP4221689A4 (en) | 2024-11-13 |
| EP4221689A1 (en) | 2023-08-09 |
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