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TR200101605T2 - Benzofuran derivatives, their preparation and uses. - Google Patents

Benzofuran derivatives, their preparation and uses.

Info

Publication number
TR200101605T2
TR200101605T2 TR2001/01605T TR200101605T TR200101605T2 TR 200101605 T2 TR200101605 T2 TR 200101605T2 TR 2001/01605 T TR2001/01605 T TR 2001/01605T TR 200101605 T TR200101605 T TR 200101605T TR 200101605 T2 TR200101605 T2 TR 200101605T2
Authority
TR
Turkey
Prior art keywords
formula
alkyl
benzofuran derivatives
aryl
preparation
Prior art date
Application number
TR2001/01605T
Other languages
Turkish (tr)
Inventor
Andersen Kim
Rottländer Mario
Peter Bogeso Klaus
Pedersen Henrik
Ruhland Thomas
Dancer Robert
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of TR200101605T2 publication Critical patent/TR200101605T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Mevcut bulus, genel formülü Formül (I) olan benzofuran türevleriyle ilgilidir. Bu formülde A, (1), (2), (3), (4) arasindan seçilir; öyle ki bunlarda; Z,O veya S'dir; s, 0 veya 1'dir, q, 0 veya 1'dir, R4, hidrojen, C1-6-alkil, C2-6-alkenil, C2-6-alkinil, C1-6-alkil-Aril veya C1-6-alkil-O-Aril'dir; D, dalli veya dogru zincir C1-6-alkilen, C2-6-alkenilen ve C2-6-alkinilenden seçilen bir aralayici gruptur; ve bunun enantomerleriyle ve farmasötik olarak kabul edilen asit ilaveli tuzlariyla ilgilidir. Bilesimler, 5-HT1A alicisina verimli sekilde baglanir. (FORMÜL VAR)The present invention relates to benzofuran derivatives whose general formula is Formula (I). In this formula, A is selected from (1), (2), (3), (4); such that; Z is O or S; s is 0 or 1, q is 0 or 1, R4 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkyl-Aryl or C1-6- alkyl-O-aryl; D is a spacer group selected from branched or straight chain C1-6-alkylene, C2-6-alkenylene and C2-6-alkynylene; and its entomers and pharmaceutically acceptable acid addition salts. Compounds are efficiently attached to the 5-HT1A receiver. (FORMULA HAVE)

TR2001/01605T 1998-12-08 1999-12-03 Benzofuran derivatives, their preparation and uses. TR200101605T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11136098P 1998-12-08 1998-12-08

Publications (1)

Publication Number Publication Date
TR200101605T2 true TR200101605T2 (en) 2001-10-22

Family

ID=22338076

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01605T TR200101605T2 (en) 1998-12-08 1999-12-03 Benzofuran derivatives, their preparation and uses.

Country Status (11)

Country Link
CN (1) CN1198813C (en)
BR (1) BR9916873A (en)
EA (1) EA003781B1 (en)
HK (1) HK1043121B (en)
ID (1) ID30330A (en)
NZ (1) NZ511751A (en)
PL (1) PL201171B1 (en)
SK (1) SK286524B6 (en)
TR (1) TR200101605T2 (en)
UA (1) UA70347C2 (en)
ZA (1) ZA200103987B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110627757B (en) * 2018-06-25 2022-01-14 北京安博睿达医药科技有限公司 Escitalopram derivative and preparation method and application thereof

Also Published As

Publication number Publication date
EA003781B1 (en) 2003-08-28
UA70347C2 (en) 2004-10-15
SK286524B6 (en) 2008-12-05
PL347934A1 (en) 2002-04-22
CN1329605A (en) 2002-01-02
BR9916873A (en) 2001-08-21
ZA200103987B (en) 2002-05-16
NZ511751A (en) 2003-09-26
ID30330A (en) 2001-11-22
PL201171B1 (en) 2009-03-31
CN1198813C (en) 2005-04-27
HK1043121B (en) 2005-12-16
SK7762001A3 (en) 2001-11-06
EA200100633A1 (en) 2001-10-22
HK1043121A1 (en) 2002-09-06

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