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Priority claimed from PCT/FR2009/000051external-prioritypatent/WO2009112677A2/en
Application filed by Sanofi AventisfiledCriticalSanofi Aventis
Publication of TN2010000333A1publicationCriticalpatent/TN2010000333A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
The invention relates to the compounds of general formula (1) in which X1, X2, X3 and X4 are, independently of one another, a nitrogen atom or a C-Ri group; W is an oxygen or sulphur atom; n is equal to 0, 1, 2 or 3; Y is an optionally substituted aryl or heteroaryl; A is the group of formula: (II), Z1, Z2, Z3 and Z4 are, independently of one another, a nitrogen atom or a C-R2 group; Ra and Rb form, together with the carbon atoms which bear them, either a partially unsaturated cycloalkyl, or an aryl; or a heterocycle, or a heteroaryl with 5 to 7 ring members comprising from one to three heteroatoms selected from O, S or N; it being possible for this cycloalkyl, this aryl, this heterocycle or this heteroaryl to be substituted with one or more substituents R3; in the form of a base or of an addition salt with an acid, and also in the form of a hydrate or of a solvate. Process for the preparation thereof and therapeutic use.
TNP2010000333A2009-01-202010-07-19Bicyclic derivativesof azabicyclic carboxamides, preparation thereof and therapeutic use thereof
TN2010000333A1
(en)