TH50339B - Healing fractures of the bone using analogue of PTHrP. - Google Patents

Abstract

DC60 (23/09/41) This invention provides a way to heal bones. And repair the fracture of the bone that is assembled By providing analogue polypeptides The concentration of peptides associated with parathyroid hormone (PTHrP) and their salts in effective doses are administered to the patient. Treatment like that, in which Analogs of polypeptides, amino acid units 22-31, form an amphipathic alpha-helix, or the use of such polypeptides in drug preparation. For the treatment of disease It heals bones and Repair broken bones This invention provides a way to heal bones. And repair fractures of bone that contain analogue polypeptide The concentration of peptides associated with parathyroid hormone (PTHrP) and their salts in effective doses are administered to the patient. In this analogue polypeptide, amino acid units 22-31 form an amphipathic, alpha-helix, or polypeptide use. Like that in preparing medicine for the treatment of the disease It heals bones and repairs bone fractures.

Claims (2)

Disclaimer (all) which will not appear on the announcement page: EDIT 3/7/2015 1. Use of polypeptide analogs of peptide-related parathyroid hormones. (PTHrP) and their salts. The analogue is the N-apical cross-section of 30 to 50 amino acid units. The amino acid units 22-31 of the PTHrP analogues are Amphipathic alpha-helix for bone-healing drug preparation And repair of fractures of the bone, which the amphipathic alpha-hilix is Glu Leu Leu Glu His Leu Leu Glu Lys Leu 2. Use of Claim No. 1, which provides analogue of PTHrP is administered by nasal congestion. 3. Use of claim 1, which has an additional component consisting of a type of orthopedic healing. It consists of a second type of heal, as a local drug, directed down to the fracture of the bone. 4. Use of the 1st joint, where the fracture of the bone is in the inner type of bone. 5. Use of claim 1, where analogue of PTHrP is administered as a system-wide drug. 6. Use of claim 1, in which amphipathic alfahi. Lyx is Glu Leu Leu Glu His Leu Leu Glu Lys Leu 7. Use of Claim 6, which the analogue of the PTHrP is Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser lleGln Asp Leu Arg Arg. Arg Glu Leu Leu Glu Lys Leu Leu Glu Lys Leu His Thr Ala NH2 (SEQ ID NO: 3) or Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser lleGln Asp Leu Arg Arg Arg Glu Leu Leu Glu His Leu Leu. Glu Lys Leu His Thr Ala NH2 (SEQ ID NO: 4) 8. Use of claim 1, in which the PTHrP analog has at least two amino acid units. Groups connected through the side chains of those units together 9. Use of claim 8 in which amino acid units connected at positions 13 and 17 or positions 26 and 30 1. 0. Use Of claim 9, in which the amino acid unit at position 17 is aspartic acid 1 1. Use of claim 10, the analog of the PTHrP is Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser lle Gln Asp Leu Arg Arg Arg Glu Leu Leu Glu Lys Leu Leu Glu Lys Leu His Thr hSerlac (SEQ ID NO: 5) or Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser lle Gln Asp. Leu Arg Arg Arg Glu Leu Leu Glu Lys Leu Leu Glu Lys Leu His Thr Ala NH2 (SEQ ID NO: 6) or 1 2. Use of Claim No. 10, where the analog of the PTHrP is the terminating N with 30 to 50 amino acid units that may be selected to be replaced at positions 5, 13, 17, 19, 26, 30, 32 and / or 34 ---------------- ------------------------------------------ 1. Using analogues of Parathyroid hormone-related polypeptides (PTHrP) and their salts. The analogue is the N-apical cross-section of 30 to 50 amino acid units. The amino acid units 22-31 of the PTHrP analogues are Amphipathic alpha-helix for bone-healing drug preparation And repair of fractures of the bone, which amphipathic alpha-helix is Glu Leu Leu Glu His Leu Leu Glu Lys Leu and Xaa are cationic amino acid units. Claim No. 1, where analogue of PTHrP is administered by nasal congestion. 3. Use of claim 1, which includes an additional component consisting of a type of orthopedic healing. It consists of a second type of heal, as a local drug, directed down to the fracture of the bone. 4. Use of the 1st joint, where the fracture of the bone is in the inner type of bone. 5. Use of claim 1, where analogue of PTHrP is administered as a system-wide drug. 6. Use of claim 1, in which amphipathic alfahi. Lyx is Glu Leu Leu Glu His Leu Leu Glu Lys Leu 7. Use of Claim 6, which the analogue of the PTHrP is Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser lleGln Asp Leu Arg Arg. Arg Glu Leu Leu Glu Lys Leu Leu Glu Lys Leu His Thr Ala NH2 (SEQ ID NO: 3) or Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser lleGln Asp Leu Arg Arg Arg Glu Leu Leu Glu His Leu Leu. Glu Lys Leu His Thr Ala NH2 (SEQ ID NO: 4) 8. Use of claim 1, in which the PTHrP analog has at least two amino acid units. The groups are connected through the side chains of those units together 9. Use of claim 8 in which the amino acid units connected at positions 13 and 17 or positions 26 and 30 1. 0. Of claim 9, where the amino acid unit at position 17 is aspartic acid 1 1. Use of Claim No. 10, which the analog of the PTHrP is: Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser lle Gln Asp Leu Arg Arg Arg Glu Leu Leu Glu Lys Leu Leu Glu Lys Leu His Thr. hSerlac (SEQ ID NO: 5) or Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser lle Gln Asp Leu Arg Arg Arg Glu Leu Leu Glu Lys Leu Leu Glu Lys Leu His Thr Ala NH2 (SEQ ID NO: 6 ) Or 1 2. Using claim 10, the analog of PTHrP is the distal N cross-section containing 30 to 50 amino acid units that may elect to be replaced at positions 5, 13, 17, 19, 26, 30, 32 and / or 34