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SU565915A1 - Di-alpha-carbalcoximethoxy-diethylsilanes displaying neutropic activity - Google Patents

Di-alpha-carbalcoximethoxy-diethylsilanes displaying neutropic activity

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Publication number
SU565915A1
SU565915A1 SU7402075856A SU2075856A SU565915A1 SU 565915 A1 SU565915 A1 SU 565915A1 SU 7402075856 A SU7402075856 A SU 7402075856A SU 2075856 A SU2075856 A SU 2075856A SU 565915 A1 SU565915 A1 SU 565915A1
Authority
SU
USSR - Soviet Union
Prior art keywords
activity
diethylsilanes
carbalcoximethoxy
neutropic
alpha
Prior art date
Application number
SU7402075856A
Other languages
Russian (ru)
Inventor
Евгений Леонидович Пидемский
Людмила Михайловна Обвинцева
Александр Анатольевич Онорин
Original Assignee
Пермский ордена Трудового Красного Знамени государственный университет имени А.М.Горького
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пермский ордена Трудового Красного Знамени государственный университет имени А.М.Горького filed Critical Пермский ордена Трудового Красного Знамени государственный университет имени А.М.Горького
Priority to SU7402075856A priority Critical patent/SU565915A1/en
Application granted granted Critical
Publication of SU565915A1 publication Critical patent/SU565915A1/en

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Description

Изобретение относитс  к элементноор ганической химии, к новым химическим с динени м, а именно к ди-(- сс -карбалкок метокси)-диэтилсиланам общей формулы (С2Нд)2Йиосн2Соор)2, Т -СдН9,С5Н,рСбН,,СдН,9, .про вл ющим нейрогроггаую активность, ко рые могут найти применение при изготов лении лекарственных препаратов, относ щ с  к. группе малых транквилизаторов. Известны кремнийорганические производные об -оксикислот обжей формулы ( С2Н5)2б((ОСНСИ2СООС2Н5)2, R fi ti Однако указаний об их биологической гивности не имеетс . Цэль изобретени  - расширение арсена средств воздействи  на живой организм. Эта достигаетс  сс -карбалкокси1 магокс ч)-диэтилсиланами; формулг-. (Т), йро вл юлпим нейротроп ую активность. Соединени  формулы (I) получают по известной реакции 2 путем взаимодействи  диэтилсилана со сложным эфиром щавелевой кислоты в присутствии хлористого цинка в качестве катализатора. Пример 1. znceg (C &4H 1C H C OCOCOOCH,(f ((OCH2COOC H Дй-( ас -карбалкоксиметокси)-диэтилсипаны представл ют собой прозрачные бесцветные жидкости, растворимые в органических растворител х : ксилоле, толуоле, бензоле и спирте и не растворимые в воде При сто нии на воздухе не измен ютс , не гигроскопичны. Рациональные названа , эмпирические формулы, физико-химические константы соединений формулы ( Г) представлены в таб. 1.Исследовани  биологического действи  ци-( cxi -карбалкоксиме-:экси)-диэтилсиланов формулы (1) ;ПроведеныНа мышахтетрагибридах и крысах линии Внстер, Соединени  формулы (1) угнетают у животкьк элементарный оборонительный условный и ориентировочно-исследовательский рефлексы, потенцируют снотворное деиствке гексенала, понижают чувствительностк нервно-мышечных синалсов к электрическо му раздражению,, про вл ют умеренно выраженный . анальгетическвй (эффект, предохран ют животных от гибели при воздействии The invention relates to elemental organic chemistry, to new chemical compounds, namely, di - (- cc-methoxy) -butyl methoxylsilanes of the general formula (C2Hd) 2HiCl2Soor) 2, T-CdH9, C5H, rSbN, CdH, 9, They have a neurorogogic activity that can be used in the manufacture of drugs that belong to the group of small tranquilizers. The organosilicon derivatives of the about -oxyacids of the burning of the formula (C2H5) 2b are known ((OCNIS2COOC2H5) 2, R fi ti However, there is no indication of their biological activity. The purpose of the invention is the expansion of the arsenic of the action on a living organism. diethylsilanes; formulas- (T), iro vyulpim neurotropic activity. The compounds of formula (I) are obtained by the known reaction of 2 by reacting diethylsilane with oxalic acid ester in the presence of zinc chloride as a catalyst. Example 1. znceg (C & 4H 1C HC OCOCOOCH, (f ((OCH2COOC H Dy- (ac -carbalkalkoxymethoxy) -diethylsipanes are clear, colorless liquids soluble in organic solvents: xylene, toluene, benzene and alcohol, and not soluble in water On standing in the air they do not change, are not hygroscopic. The rational formulas are named, empirical formulas, and physicochemical constants of the compounds of formula (D) are presented in Table 1. Studies of the biological effects of cy- (cxi -carbalkoxime-: exi) - diethylsilanes of the formula (1); Held on mouse tetrahybrid hybrids and rats ling and Westster. Compounds of formula (1) inhibit elementary defensive conditioned and exploratory reflexes in the stomach, potentiate the hypnotic effect of hexenal, decrease the sensitivity of the neuromuscular muscles to electrical irritation, exhibit a moderately pronounced analgesic effect (the effect of protecting animals from death when exposed

электрического тока. Результаты испытаний даны в табл. 2.electric current. The test results are given in table. 2

Наибольшую активность про вл ет7 ди- (оС -карбутоксиметокси)-диэтилсилан. Соединени  формулы .{) по своей активности; превосход т действие триоксазина (дл  характеристики нейтронной активности триоксазина в табл. 2 использованы, данные Б,А. Баргтейл (1973).The most activity is 7 di- (oC -carbutoxymethoxy) -diethylsilane. Compounds of formula. {) By their activity; superior to the effect of trioxazin (for the characterization of the neutron activity of trioxazin in Table 2 used, data B, A. Bargteyl (1973).

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4 о-р мул изобретени 4 Oral Mule of Invention

Ди- { рС -карбалкоксиметокси)-диэтилсиланы обшей формулыDi- {pC -carbalkoxymethoxy) diethylsilanes of the general formula

(C2H5)2SUOCH2C60R)2,(C2H5) 2SUOCH2C60R) 2,

Т -CjjH jCjH JI ,,з ,С9Н,9, про вл ющие нейротропную активность.T -CjjH jCjH JI ,, h, C9H, 9, exhibiting neurotropic activity.

10ten

Источники информации:, прин тые во вни мание при экспертизе:Sources of information: taken into consideration during examination:

1.Лапкин И.И. и др. Взаимодействие диэтилсилана со сложными эфирами ,d. -оксикислот , ЖОХ 1971. 41 с. 1263.1.Lapkin I.I. et al. Diethylsilane interaction with esters, d. -oxyacids, JOH 1971. 41 p. 1263.

2.Лапкин И. И. и др. Взаимодействие диэтилсилана со сложными эфирами кислот, ЖОХ. 1969, № 3-4, с. 549.2. Lapkin I. I. et al. Interaction of diethylsilane with esters of acids, JOH. 1969, No. 3-4, p. 549.

SU7402075856A 1974-10-07 1974-10-07 Di-alpha-carbalcoximethoxy-diethylsilanes displaying neutropic activity SU565915A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU7402075856A SU565915A1 (en) 1974-10-07 1974-10-07 Di-alpha-carbalcoximethoxy-diethylsilanes displaying neutropic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU7402075856A SU565915A1 (en) 1974-10-07 1974-10-07 Di-alpha-carbalcoximethoxy-diethylsilanes displaying neutropic activity

Publications (1)

Publication Number Publication Date
SU565915A1 true SU565915A1 (en) 1977-07-25

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2751347C2 (en) * 2016-09-13 2021-07-13 Хенкель Аг Унд Ко. Кгаа Silanes and curable compositions including the mentioned silanes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2751347C2 (en) * 2016-09-13 2021-07-13 Хенкель Аг Унд Ко. Кгаа Silanes and curable compositions including the mentioned silanes

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