SU1500289A1 - Method of treatment of injures and inflammatory lesions of the anterior part of the eye of the patients ill with diabetes mellitus - Google Patents

Abstract

This invention relates to ophthalmology. In order to reduce the duration of treatment of injuries and inflammatory lesions of the anterior eye in patients with diabetes mellitus, local administration of insulin and glucose is administered, which is administered as a mixture with saline solution, taken in a specific proportion. The mixture is administered by instillation or single subconjunctival injections 30 minutes after ingestion, with the daily dose of the mixture determined by the formula C = (A-B). 30 where the C-daily dose of the mixture

A-concentration of glucose in the tear of the patient

B-age norm of glucose in the tear fluid.

Description

The invention relates to medicine, in particular to ophthalmology, and can be used to treat inflammatory lesions and injuries of the anterior eye in diabetes mellitus.

The aim of the invention is to reduce the duration of treatment.

The method is carried out in a follow-up manner.

A mixture containing, in wt%, is introduced locally: insulin 17.5-18.0; glucose 60,0-61,4j saline - the rest.

The use of the drug mixture is that the mixture is administered topically into the conjunctival cavity, either by instillation 30 minutes after each meal, or by single subconjunctival injections 30 minutes after breakfast.

wherein the daily dose of the drug mixture is determined from the formula:

C (A - B) 30,

where C is the therapeutic dose of the drug in

day;

And - concentration of glucose in a tear of the inspected patient with diabetes mellitus;

B - the age norm of glucose content in the tear fluid of healthy people, which in men and women aged 18-22 years is 0.236 + 0.014 and 0.250j-0.016 mmol / l, respectively, and in elderly people - 0.163+ iO, 014 mmol / Jl;

30 - experimentally calculated coefficient.

and the amount of C, rounded to a whole number, determines the amount of AU of the medicinal mixture instillable. per day or once injected under the conjunctiva.

Example. Patient S., 20 years old, suffers from insulin-dependent diabetes mellitus, diabetes and initial diabetic cataracts in both eyes. Erosis of the cornea os. The glucose concentration in the tear fluid was found to be 0.360 mmol / l. The normal glucose content in a tear, corresponding to its age, is 0.236 mmol / l. Daily dose of the drug mixture for local use: C (0.360; O, 263) 30 2.91 U, Next, by rounding this value to the whole figure (2.91

1500289

ten

15

Farita disappeared. Further supportive therapy, carried out by the patient, stabilized visual functions.

The use of this method has reduced the time of epithelialization of corneal erosions on average by 9.9 + 4.9 days. In 80% of patients with chronic scaly blepharitis, the use of this method led to an improvement, and in the remaining 20% - to the stabilization of the process, if unsuccessful, applied prior therapy.

Claims (2)

Invention Formula The method of treatment of injuries and paralytic lesions of the anterior from “3, 0 U”), divided the calculated daily 20 cases of the eye in patients with diabetes 25 3 doses per dose (1.0 U, or one drop 30 minutes after each meal). After 10 days of such therapy, the further development of the cataract ceased, the patient’s visual functions stabilized, and erosion was absorbed. Example 2. Ill M., 60 years old, has been suffering from insulin-dependent diabetes mellitus for about 5 years, 3 years from co-morbidity with scale blepharitis, which is not / is improving during therapy with antiseptics and desensitizing drugs. The concentration of glucose in the tear fluid was 0.393 mmol / l, with a normal age of 0.163 mmol / l. The daily dose of the drug mixture was found to be 7.0 U after appropriate calculation. The patient was administered local drug therapy. Moreover, all 7 units (7 drops) of the mixture were administered daily, 30 minutes after breakfast, by injection under the conjunctiva. Already after 12 days of occurrence 35 40 By administering insulin g-glucose locally, characterized in that, in order to shorten the treatment time, these drugs are administered as a mixture of insulin, glucose and saline in the following ratio of components, May. %; Insulin17,5-18,0 Glucose60.0-61.4 Physiological mortar remaining at the same time, the mixture is administered by instillations or single subconjunctive injections 30 minutes after a meal, and the daily dose of the mixture is determined from the formula C (A - B) 30, where C is the daily dose of the mixture; And - concentration of glucose in a tear . the patient; B - the age norm of glucose content in the tear fluid. Farita disappeared. Further supportive therapy, carried out by the patient, stabilized visual functions. The use of this method has reduced the time of epithelialization of corneal erosions on average by 9.9 + 4.9 days. In 80% of patients with chronic scaly blepharitis, the use of this method led to an improvement, and in the remaining 20% - to the stabilization of the process, if unsuccessful, applied prior therapy. Invention Formula The method of treatment of lesions and spinal lesions of the anterior from By administering insulin g-glucose locally, characterized in that, in order to shorten the treatment time, these drugs are administered as a mixture of insulin, glucose and saline in the following ratio of components, May. %; Insulin17,5-18,0 Glucose60.0-61.4 Physiological mortar remaining at the same time, the mixture is administered by instillations or single subconjunctive injections 30 minutes after a meal, and the daily dose of the mixture is determined from the formula C (A - B) 30, where C is the daily dose of the mixture; And - concentration of glucose in a tear . the patient; B - the age norm of glucose content in the tear fluid.