SMT202000558T1 - Animali non umani aventi un locus di catena leggera di immunoglobulina lambda ingegnerizzata - Google Patents

Animali non umani aventi un locus di catena leggera di immunoglobulina lambda ingegnerizzata

Info

Publication number: SMT202000558T1
Authority: SM; San Marino
Prior art keywords: light chain; human animals; chain locus; lambda light; engineered immunoglobulin
Prior art date: 2016-11-04

Application number

SM20200558T

Other languages

English (en)

Inventor

John Mcwhirter

Lynn Macdonald

Andrew J Murphy

Naxin Tu

Vera Voronina

Faith Harris

Chunguang Guo

Natasha Levenkova

Original Assignee

Regeneron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-11-04

Filing date

2017-11-03

Publication date

2020-11-10

2017-11-03 Application filed by Regeneron Pharma filed Critical Regeneron Pharma

2020-11-10 Publication of SMT202000558T1 publication Critical patent/SMT202000558T1/it

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Environmental Sciences (AREA)
Veterinary Medicine (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Biodiversity & Conservation Biology (AREA)
Animal Husbandry (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cell Biology (AREA)
Mycology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

SM20200558T 2016-11-04 2017-11-03 Animali non umani aventi un locus di catena leggera di immunoglobulina lambda ingegnerizzata SMT202000558T1 (it)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US201662417845P	2016-11-04	2016-11-04
US201762567932P	2017-10-04	2017-10-04
PCT/US2017/060006 WO2018128691A1 (en)	2016-11-04	2017-11-03	Non-human animals having an engineered immunoglobulin lambda light chain locus
EP17863293.1A EP3407709B9 (en)	2016-11-04	2017-11-03	Non-human animals having an engineered immunoglobulin lambda light chain locus

Publications (1)

Publication Number	Publication Date
SMT202000558T1 true SMT202000558T1 (it)	2020-11-10

Family

ID=62025924

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SM20200558T SMT202000558T1 (it)	2016-11-04	2017-11-03	Animali non umani aventi un locus di catena leggera di immunoglobulina lambda ingegnerizzata
SM20220259T SMT202200259T1 (it)	2016-11-04	2017-11-03	Animali non umani aventi un locus di catena leggera di immunoglobulina lambda ingegnerizzata

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SM20220259T SMT202200259T1 (it)	2016-11-04	2017-11-03	Animali non umani aventi un locus di catena leggera di immunoglobulina lambda ingegnerizzata

Country Status (25)

Country	Link
US (2)	US10820582B2 (it)
EP (3)	EP4082334A1 (it)
JP (4)	JP6884860B2 (it)
KR (4)	KR102319069B1 (it)
CN (2)	CN114369157A (it)
AU (2)	AU2017391167B2 (it)
BR (1)	BR112019008675A2 (it)
CA (1)	CA3038720A1 (it)
CY (1)	CY1123491T1 (it)
DK (2)	DK3407709T3 (it)
ES (2)	ES2823305T3 (it)
HR (2)	HRP20220888T1 (it)
HU (2)	HUE061980T2 (it)
IL (2)	IL308197A (it)
LT (2)	LT3766343T (it)
MA (2)	MA44091A (it)
MX (2)	MX2019005256A (it)
PL (2)	PL3407709T3 (it)
PT (2)	PT3407709T (it)
RS (2)	RS60886B1 (it)
RU (2)	RU2021129958A (it)
SG (2)	SG10201913483XA (it)
SI (2)	SI3766343T1 (it)
SM (2)	SMT202000558T1 (it)
WO (1)	WO2018128691A1 (it)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US10881084B2 (en)	2010-07-26	2021-01-05	Trianni, Inc	Transgenic animals and methods of use
US10662256B2 (en)	2010-07-26	2020-05-26	Trianni, Inc.	Transgenic mammals and methods of use thereof
SI3597038T1 (sl) *	2012-02-01	2021-07-30	Regeneron Pharmaceuticals, Inc.	Humanizirani glodalci, ki izražajo težke verige, ki vsebujejo domene VL
US10813346B2 (en)	2015-12-03	2020-10-27	Trianni, Inc.	Enhanced immunoglobulin diversity
SG10201913483XA (en)	2016-11-04	2020-03-30	Regeneron Pharma	Non-human animals having an engineered immunoglobulin lambda light chain locus
CA3093995A1 (en)	2018-03-24	2019-10-03	Regeneron Pharmaceuticals, Inc.	Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof
CA3093850A1 (en)	2018-03-26	2019-10-03	Regeneron Pharmaceuticals, Inc.	Humanized rodents for testing therapeutic agents
IL305557A (en)	2018-06-14	2023-10-01	Regeneron Pharma	Non-human animals capable of engineered dh-dh rearrangement and uses thereof
SG11202107589PA (en)	2019-02-22	2021-08-30	Regeneron Pharma	Rodents having genetically modified sodium channels and methods of use thereof
WO2021003152A1 (en) *	2019-07-01	2021-01-07	Trianni, Inc.	Transgenic mammals and methods of use thereof
EP4211155A1 (en)	2020-09-11	2023-07-19	Regeneron Pharmaceuticals, Inc.	Identification and production of antigen-specific antibodies
WO2022132943A1 (en)	2020-12-16	2022-06-23	Regeneron Pharmaceuticals, Inc.	Mice expressing humanized fc alpha receptors
WO2022140219A1 (en)	2020-12-23	2022-06-30	Regeneron Pharmaceuticals, Inc.	Nucleic acids encoding anchor modified antibodies and uses thereof
AU2021409906A1 (en)	2020-12-23	2023-06-15	Regeneron Pharmaceuticals, Inc.	Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same
GB202217978D0 (en) *	2022-11-30	2023-01-11	Petmedix Ltd	Rodents expressing a common light chain

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU3328493A (en) *	1991-12-17	1993-07-19	Genpharm International, Inc.	Transgenic non-human animals capable of producing heterologous antibodies
US5670356A (en)	1994-12-12	1997-09-23	Promega Corporation	Modified luciferase
US5874304A (en)	1996-01-18	1999-02-23	University Of Florida Research Foundation, Inc.	Humanized green fluorescent protein genes and methods
GB9823930D0 (en)	1998-11-03	1998-12-30	Babraham Inst	Murine expression of human ig\ locus
US7105348B2 (en)	2000-10-31	2006-09-12	Regeneron Pharmaceuticals, Inc.	Methods of modifying eukaryotic cells
US6586251B2 (en)	2000-10-31	2003-07-01	Regeneron Pharmaceuticals, Inc.	Methods of modifying eukaryotic cells
US6596541B2 (en)	2000-10-31	2003-07-22	Regeneron Pharmaceuticals, Inc.	Methods of modifying eukaryotic cells
WO2003047336A2 (en)	2001-11-30	2003-06-12	Abgenix, Inc.	TRANSGENIC ANIMALS BEARING HUMAN Igμ LIGHT CHAIN GENES
CN103205436B (zh) *	2003-07-15	2016-05-25	人类多克隆治疗公司	人源化免疫球蛋白基因座
SI2041177T1 (sl)	2006-06-02	2012-03-30	Regeneron Pharma	Visoko afinitetna protitelesa za humani IL receptor
DK2346994T3 (da)	2008-09-30	2022-02-28	Ablexis Llc	Knock-in-mus til fremstilling af kimære antistoffer
CN102292445A (zh) *	2008-12-18	2011-12-21	伊拉兹马斯大学鹿特丹医学中心	表达人源化抗体的非人转基因动物及其用途
NZ597481A (en) *	2009-07-08	2013-10-25	Kymab Ltd	Animal models and therapeutic molecules
RU2425880C2 (ru) *	2009-07-30	2011-08-10	Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН	Способ получения трансгенных мышей
WO2011115476A1 (en)	2010-03-17	2011-09-22	N.V. Nutricia	Infant nutrition for improving fatty acid composition of brain membranes later in life
SMT201900241T1 (it) *	2010-06-22	2019-05-10	Regeneron Pharma	Topi esprimenti una catena leggera ibrida di immunoglobulina con una regione variabile umana
SI4067496T1 (sl)	2011-02-25	2023-07-31	Regeneron Pharmaceuticals, Inc.	Miši ADAM6
KR20140082824A (ko)	2011-10-17	2014-07-02	리제너론 파아마슈티컬스, 인크.	제한된 면역글로불린 중쇄 마우스
US9253965B2 (en)	2012-03-28	2016-02-09	Kymab Limited	Animal models and therapeutic molecules
CA2859408C (en) *	2011-12-20	2020-06-16	Regeneron Pharmaceuticals, Inc.	Humanized light chain mice
ES2678221T3 (es) *	2013-02-20	2018-08-09	Regeneron Pharmaceuticals, Inc.	Animales no humanos con secuencias de cadena pesada de inmunoglobulina modificadas
EP2958990B1 (en)	2013-02-20	2019-10-16	Regeneron Pharmaceuticals, Inc.	Genetic modification of rats
US9788534B2 (en) *	2013-03-18	2017-10-17	Kymab Limited	Animal models and therapeutic molecules
SG10201802295XA (en) *	2013-10-01	2018-04-27	Kymab Ltd	Animal Models and Therapeutic Molecules
KR101773782B1 (ko)	2013-12-11	2017-09-01	리제너론 파마슈티칼스 인코포레이티드	게놈의 표적화된 변형을 위한 방법 및 조성물
SG10201913804WA (en)	2014-06-06	2020-03-30	Regeneron Pharma	Methods and compositions for modifying a targeted locus
PL3155099T3 (pl)	2014-06-23	2018-08-31	Regeneron Pharmaceuticals, Inc.	Łączenie dna mediowane nukleazą
IL301900A (en)	2014-11-21	2023-06-01	Regeneron Pharma	Methods and compositions for targeted genetic modification using paired guide rnas
KR102530821B1 (ko)	2014-12-19	2023-05-10	리제너론 파마슈티칼스 인코포레이티드	단일 단계 다중 표적화를 통한 표적화된 유전자 변형을 위한 방법 및 조성물
SG10201913483XA (en)	2016-11-04	2020-03-30	Regeneron Pharma	Non-human animals having an engineered immunoglobulin lambda light chain locus

2017
- 2017-11-03 SG SG10201913483XA patent/SG10201913483XA/en unknown
- 2017-11-03 EP EP22164751.4A patent/EP4082334A1/en active Pending
- 2017-11-03 CN CN202210050898.8A patent/CN114369157A/zh active Pending
- 2017-11-03 DK DK17863293.1T patent/DK3407709T3/da active
- 2017-11-03 SM SM20200558T patent/SMT202000558T1/it unknown
- 2017-11-03 MA MA044091A patent/MA44091A/fr unknown
- 2017-11-03 CN CN201780067880.6A patent/CN109996441B/zh active Active
- 2017-11-03 HR HRP20220888TT patent/HRP20220888T1/hr unknown
- 2017-11-03 KR KR1020197015717A patent/KR102319069B1/ko active IP Right Grant
- 2017-11-03 US US15/803,513 patent/US10820582B2/en active Active
- 2017-11-03 HU HUE20180508A patent/HUE061980T2/hu unknown
- 2017-11-03 PT PT178632931T patent/PT3407709T/pt unknown
- 2017-11-03 SI SI201731147T patent/SI3766343T1/sl unknown
- 2017-11-03 RU RU2021129958A patent/RU2021129958A/ru unknown
- 2017-11-03 AU AU2017391167A patent/AU2017391167B2/en active Active
- 2017-11-03 LT LTEP20180508.2T patent/LT3766343T/lt unknown
- 2017-11-03 IL IL308197A patent/IL308197A/en unknown
- 2017-11-03 KR KR1020237002504A patent/KR102658529B1/ko active IP Right Grant
- 2017-11-03 DK DK20180508.2T patent/DK3766343T3/da active
- 2017-11-03 PT PT201805082T patent/PT3766343T/pt unknown
- 2017-11-03 EP EP20180508.2A patent/EP3766343B1/en active Active
- 2017-11-03 BR BR112019008675A patent/BR112019008675A2/pt unknown
- 2017-11-03 KR KR1020217034468A patent/KR102492433B1/ko active IP Right Grant
- 2017-11-03 CA CA3038720A patent/CA3038720A1/en active Pending
- 2017-11-03 SG SG11201903344XA patent/SG11201903344XA/en unknown
- 2017-11-03 PL PL17863293T patent/PL3407709T3/pl unknown
- 2017-11-03 KR KR1020247012338A patent/KR20240055863A/ko active Search and Examination
- 2017-11-03 HU HUE17863293A patent/HUE052087T2/hu unknown
- 2017-11-03 ES ES17863293T patent/ES2823305T3/es active Active
- 2017-11-03 LT LTEP17863293.1T patent/LT3407709T/lt unknown
- 2017-11-03 SM SM20220259T patent/SMT202200259T1/it unknown
- 2017-11-03 JP JP2019522647A patent/JP6884860B2/ja active Active
- 2017-11-03 WO PCT/US2017/060006 patent/WO2018128691A1/en active Application Filing
- 2017-11-03 RS RS20201205A patent/RS60886B1/sr unknown
- 2017-11-03 MA MA053935A patent/MA53935A/fr unknown
- 2017-11-03 IL IL266282A patent/IL266282B2/en unknown
- 2017-11-03 MX MX2019005256A patent/MX2019005256A/es unknown
- 2017-11-03 PL PL20180508.2T patent/PL3766343T3/pl unknown
- 2017-11-03 SI SI201730381T patent/SI3407709T1/sl unknown
- 2017-11-03 EP EP17863293.1A patent/EP3407709B9/en active Active
- 2017-11-03 RS RS20220669A patent/RS63390B1/sr unknown
- 2017-11-03 ES ES20180508T patent/ES2915609T3/es active Active
- 2017-11-03 RU RU2019112589A patent/RU2757665C2/ru active
2019
- 2019-05-03 MX MX2021010556A patent/MX2021010556A/es unknown
2020
- 2020-09-03 HR HRP20201403TT patent/HRP20201403T1/hr unknown
- 2020-09-24 US US17/031,367 patent/US20210029978A1/en active Pending
- 2020-10-29 CY CY20201101022T patent/CY1123491T1/el unknown
2021
- 2021-03-08 JP JP2021036180A patent/JP2021090455A/ja not_active Withdrawn
2022
- 2022-07-07 JP JP2022109658A patent/JP7386292B2/ja active Active
2023
- 2023-02-17 JP JP2023023312A patent/JP2023053400A/ja active Pending
2024
- 2024-01-31 AU AU2024200582A patent/AU2024200582A1/en active Pending

Also Published As

Publication number	Publication date
WO2018128691A8 (en)	2019-02-28
SI3766343T1 (sl)	2022-06-30
RU2021129958A (ru)	2021-11-02
RU2757665C2 (ru)	2021-10-20
IL266282B2 (en)	2024-04-01
IL266282A (en)	2019-06-30
LT3766343T (lt)	2022-06-10
DK3766343T3 (da)	2022-06-20
PL3766343T3 (pl)	2022-09-26
EP3407709A1 (en)	2018-12-05
IL308197A (en)	2024-01-01
MX2021010556A (es)	2021-10-01
EP3407709B9 (en)	2021-10-06
KR102492433B1 (ko)	2023-01-30
HRP20201403T1 (hr)	2020-11-27
PT3407709T (pt)	2020-08-20
KR20210134059A (ko)	2021-11-08
DK3407709T3 (da)	2020-08-31
WO2018128691A1 (en)	2018-07-12
CY1123491T1 (el)	2022-03-24
JP2020501516A (ja)	2020-01-23
JP2022130725A (ja)	2022-09-06
ES2915609T3 (es)	2022-06-23
EP4082334A1 (en)	2022-11-02
EP3407709B1 (en)	2020-07-29
SG11201903344XA (en)	2019-05-30
KR20240055863A (ko)	2024-04-29
SG10201913483XA (en)	2020-03-30
KR102319069B1 (ko)	2021-11-01
MX2019005256A (es)	2019-08-05
SMT202200259T1 (it)	2022-07-21
PL3407709T3 (pl)	2021-01-11
RU2019112589A3 (it)	2021-03-30
RS60886B1 (sr)	2020-11-30
US20210029978A1 (en)	2021-02-04
MA44091A (fr)	2018-10-24
BR112019008675A2 (pt)	2019-07-09
EP3766343A1 (en)	2021-01-20
HUE052087T2 (hu)	2021-04-28
EP3766343B1 (en)	2022-05-11
CN109996441B (zh)	2022-02-08
CN109996441A (zh)	2019-07-09
US20180125043A1 (en)	2018-05-10
JP2021090455A (ja)	2021-06-17
IL266282B1 (en)	2023-12-01
JP7386292B2 (ja)	2023-11-24
AU2024200582A1 (en)	2024-03-28
CA3038720A1 (en)	2018-07-12
KR20190076024A (ko)	2019-07-01
JP2023053400A (ja)	2023-04-12
KR102658529B1 (ko)	2024-04-19
RU2019112589A (ru)	2020-12-04
RS63390B1 (sr)	2022-08-31
ES2823305T3 (es)	2021-05-06
AU2017391167B2 (en)	2024-02-15
PT3766343T (pt)	2022-05-30
HRP20220888T1 (hr)	2022-10-28
MA53935A (fr)	2021-12-22
HUE061980T2 (hu)	2023-09-28
NZ753456A (en)	2021-08-27
KR20230020550A (ko)	2023-02-10
CN114369157A (zh)	2022-04-19
SI3407709T1 (sl)	2020-10-30
LT3407709T (lt)	2020-10-12
JP6884860B2 (ja)	2021-06-09
US10820582B2 (en)	2020-11-03
AU2017391167A1 (en)	2019-05-30

Publication	Publication Date	Title
IL266282A (en)	2019-06-30	Non-human animals with a transgenic immunoglobulin light chain locus
IL274797A (en)	2020-07-30	Non-human animals with engineered immunoglobulin light chain and uses thereof
HK1258227A1 (zh)	2019-11-08	具有修飾的免疫球蛋白重鏈序列的非人類動物
HK1250038A1 (zh)	2018-11-23	選擇結合抗原的輕鏈可變區的非人動物
HUE054612T2 (hu)	2021-09-28	Humanizált limfocitaaktiváló gén 3-t tartalmazó nem-humán állatok
LT3597037T (lt)	2021-06-10	Humanizuoti gyvūnai, išskyrus žmones, su apribotu imunoglobulino sunkiosios grandinės lokusu
IL273749A (en)	2020-05-31	Antibody-vegfr light chain fusion protein
DK3129400T3 (da)	2020-06-08	Ikke-humane dyr med humaniserede Fc-gamma-receptorer
IL253579A0 (en)	2017-09-28	Anti-light chain substituent antibodies
IL268049A (en)	2019-09-26	Human antibodies from transgenic rodents with multiple immunoglobulin heavy chain LOCIs
HK1258306A1 (zh)	2019-11-08	具有共同輕鏈的轉基因兔
ITUB20160763A1 (it)	2016-04-25	Imbracatura per cani guida perfezionata