SMT201600357B - Inibitori di iap - Google Patents

Inibitori di iap

Info

Publication number: SMT201600357B
Authority: SM; San Marino
Prior art keywords: iap inhibitors; iap; inhibitors
Prior art date: 2012-01-03

Application number

SM201600357T

Other languages

English (en)

Inventor

Frederick Cohen

Lewis J Gazzard

Vickie Hsiao-Wei Tsui

John A Flygare

Original Assignee

Curis Inc

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-01-03

Filing date

2016-10-06

Publication date

2016-11-10

2016-10-06 Application filed by Curis Inc, Genentech Inc filed Critical Curis Inc

2016-11-10 Publication of SMT201600357B publication Critical patent/SMT201600357B/it

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Thiazole And Isothizaole Compounds (AREA)

SM201600357T 2012-01-03 2016-10-06 Inibitori di iap SMT201600357B (it)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201261582760P	2012-01-03	2012-01-03
PCT/US2013/020124 WO2013103703A1 (en)	2012-01-03	2013-01-03	Inhibitors of iap

Publications (1)

Publication Number	Publication Date
SMT201600357B true SMT201600357B (it)	2016-11-10

Family

ID=48695302

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SM201600357T SMT201600357B (it)	2012-01-03	2016-10-06	Inibitori di iap

Country Status (41)

Country	Link
US (6)	US8716236B2 (it)
EP (2)	EP3133073B1 (it)
JP (2)	JP5747137B2 (it)
KR (3)	KR101553792B1 (it)
CN (2)	CN107915728B (it)
AR (2)	AR089623A1 (it)
AU (1)	AU2013202780B2 (it)
BR (1)	BR112014016637B1 (it)
CA (1)	CA2861637C (it)
CL (1)	CL2014001770A1 (it)
CO (1)	CO7020915A2 (it)
CR (1)	CR20140367A (it)
CY (2)	CY1118371T1 (it)
DK (2)	DK2800749T3 (it)
EC (1)	ECSP14011792A (it)
ES (2)	ES2672809T3 (it)
HK (1)	HK1203949A1 (it)
HR (2)	HRP20161381T1 (it)
HU (2)	HUE031305T2 (it)
IL (2)	IL242314A (it)
LT (2)	LT2800749T (it)
MA (1)	MA35895B1 (it)
ME (2)	ME02526B (it)
MX (1)	MX336294B (it)
MY (1)	MY178390A (it)
NO (1)	NO2755614T3 (it)
NZ (1)	NZ627480A (it)
PE (1)	PE20142182A1 (it)
PH (2)	PH12014501534B1 (it)
PL (2)	PL2800749T3 (it)
PT (2)	PT3133073T (it)
RS (2)	RS57438B1 (it)
RU (2)	RU2728789C2 (it)
SG (1)	SG11201403784QA (it)
SI (2)	SI3133073T1 (it)
SM (1)	SMT201600357B (it)
TR (1)	TR201808088T4 (it)
TW (1)	TWI503318B (it)
UA (1)	UA114417C2 (it)
WO (1)	WO2013103703A1 (it)
ZA (1)	ZA201405535B (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO2755614T3 (it) *	2012-01-03	2018-03-31
WO2016079527A1 (en)	2014-11-19	2016-05-26	Tetralogic Birinapant Uk Ltd	Combination therapy
WO2016097773A1 (en)	2014-12-19	2016-06-23	Children's Cancer Institute	Therapeutic iap antagonists for treating proliferative disorders
CN109705191B (zh) *	2017-10-25	2022-04-29	广东东阳光药业有限公司	Iap抑制剂及其在药物中的应用
BR112020009369A2 (pt)	2017-11-13	2020-10-13	Chia Tai Tianqing Pharmaceutical Group Co., Ltd	miméticos de smac usados como inibidores de iap e seus usos
CN112533898A (zh)	2018-07-31	2021-03-19	日商泛美克斯股份有限公司	杂环化合物
WO2021020585A1 (ja)	2019-07-31	2021-02-04	ファイメクス株式会社	複素環化合物
US20230029259A1 (en) *	2019-12-02	2023-01-26	Ascentage Pharma (Suzhou) Co., Ltd.	Combination of iap inhibitors and parp or mek inhibitors or other chemotherapeutic agents
CN114980883A (zh)	2020-01-20	2022-08-30	阿斯利康(瑞典)有限公司	用于治疗癌症的表皮生长因子受体酪氨酸激酶抑制剂
WO2023239422A2 (en)	2021-10-22	2023-12-14	University Of Houston System	Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancers of epithelial tissues

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4526988A (en)	1983-03-10	1985-07-02	Eli Lilly And Company	Difluoro antivirals and intermediate therefor
WO1998046576A2 (en)	1997-04-15	1998-10-22	Genentech, Inc.	Halo-alkoxycarbonyl prodrugs
KR100984459B1 (ko) *	2004-07-02	2010-09-29	제넨테크, 인크.	Ｉａｐ의 억제제
EP1836201B2 (en) *	2004-12-20	2013-09-04	Genentech, Inc.	Pyrrolidine inhibitors of iap
EP2102229B1 (en)	2006-10-12	2014-03-26	Novartis AG	Pyrrolydine derivatives as iap inhibitors
RU2491276C2 (ru) *	2007-04-30	2013-08-27	Дженентек, Инк.	Ингибиторы iap
NO2755614T3 (it)	2012-01-03	2018-03-31
USD690416S1 (en)	2012-12-12	2013-09-24	Pharmajet, Inc.	Needle-free syringe

2012
- 2012-09-13 NO NO12832667A patent/NO2755614T3/no unknown
2013
- 2013-01-02 AR ARP130100006A patent/AR089623A1/es not_active Application Discontinuation
- 2013-01-03 UA UAA201408260A patent/UA114417C2/uk unknown
- 2013-01-03 SG SG11201403784QA patent/SG11201403784QA/en unknown
- 2013-01-03 NZ NZ627480A patent/NZ627480A/en unknown
- 2013-01-03 RS RS20180755A patent/RS57438B1/sr unknown
- 2013-01-03 ME MEP-2016-235A patent/ME02526B/me unknown
- 2013-01-03 DK DK13733613.7T patent/DK2800749T3/en active
- 2013-01-03 KR KR1020147021597A patent/KR101553792B1/ko active IP Right Grant
- 2013-01-03 RU RU2016124658A patent/RU2728789C2/ru active
- 2013-01-03 CN CN201711212712.XA patent/CN107915728B/zh active Active
- 2013-01-03 BR BR112014016637-4A patent/BR112014016637B1/pt active IP Right Grant
- 2013-01-03 CN CN201380012308.1A patent/CN104159897A/zh active Pending
- 2013-01-03 AU AU2013202780A patent/AU2013202780B2/en active Active
- 2013-01-03 PE PE2014001069A patent/PE20142182A1/es active IP Right Grant
- 2013-01-03 PT PT161896618T patent/PT3133073T/pt unknown
- 2013-01-03 PT PT137336137T patent/PT2800749T/pt unknown
- 2013-01-03 SI SI201331047T patent/SI3133073T1/en unknown
- 2013-01-03 JP JP2014551313A patent/JP5747137B2/ja active Active
- 2013-01-03 DK DK16189661.8T patent/DK3133073T3/en active
- 2013-01-03 TW TW102100188A patent/TWI503318B/zh active
- 2013-01-03 ES ES16189661.8T patent/ES2672809T3/es active Active
- 2013-01-03 KR KR1020187012124A patent/KR101917992B1/ko active IP Right Grant
- 2013-01-03 PL PL13733613T patent/PL2800749T3/pl unknown
- 2013-01-03 ES ES13733613.7T patent/ES2594856T3/es active Active
- 2013-01-03 SI SI201330343A patent/SI2800749T1/sl unknown
- 2013-01-03 WO PCT/US2013/020124 patent/WO2013103703A1/en active Application Filing
- 2013-01-03 RS RS20160910A patent/RS55327B1/sr unknown
- 2013-01-03 LT LTEP13733613.7T patent/LT2800749T/lt unknown
- 2013-01-03 ME MEP-2018-161A patent/ME03084B/me unknown
- 2013-01-03 MX MX2014007895A patent/MX336294B/es unknown
- 2013-01-03 LT LTEP16189661.8T patent/LT3133073T/lt unknown
- 2013-01-03 MY MYPI2014001966A patent/MY178390A/en unknown
- 2013-01-03 TR TR2018/08088T patent/TR201808088T4/tr unknown
- 2013-01-03 HU HUE13733613A patent/HUE031305T2/hu unknown
- 2013-01-03 EP EP16189661.8A patent/EP3133073B1/en active Active
- 2013-01-03 PL PL16189661T patent/PL3133073T3/pl unknown
- 2013-01-03 EP EP13733613.7A patent/EP2800749B1/en active Active
- 2013-01-03 KR KR1020157014670A patent/KR101855566B1/ko active IP Right Grant
- 2013-01-03 US US13/733,244 patent/US8716236B2/en active Active
- 2013-01-03 RU RU2014130171/04A patent/RU2593259C2/ru active
- 2013-01-03 CA CA2861637A patent/CA2861637C/en active Active
- 2013-01-03 HU HUE16189661A patent/HUE037760T2/hu unknown
2014
- 2014-05-05 US US14/269,739 patent/US9238675B2/en active Active
- 2014-06-26 IL IL242314A patent/IL242314A/en active IP Right Grant
- 2014-06-26 IL IL233386A patent/IL233386A/en active IP Right Grant
- 2014-07-01 CL CL2014001770A patent/CL2014001770A1/es unknown
- 2014-07-02 PH PH12014501534A patent/PH12014501534B1/en unknown
- 2014-07-25 CO CO14161919A patent/CO7020915A2/es unknown
- 2014-07-25 ZA ZA2014/05535A patent/ZA201405535B/en unknown
- 2014-07-31 EC ECIEPI201411792A patent/ECSP14011792A/es unknown
- 2014-07-31 CR CR20140367A patent/CR20140367A/es not_active Application Discontinuation
- 2014-08-03 MA MA37254A patent/MA35895B1/fr unknown
2015
- 2015-05-08 PH PH12015501038A patent/PH12015501038B1/en unknown
- 2015-05-11 JP JP2015096425A patent/JP2015199738A/ja active Pending
- 2015-05-13 HK HK15104538.4A patent/HK1203949A1/xx unknown
- 2015-12-18 US US14/974,140 patent/US9586991B2/en active Active
2016
- 2016-10-06 SM SM201600357T patent/SMT201600357B/it unknown
- 2016-10-25 HR HRP20161381TT patent/HRP20161381T1/hr unknown
- 2016-12-07 CY CY20161101257T patent/CY1118371T1/el unknown
2017
- 2017-01-31 US US15/420,817 patent/US20170136084A1/en not_active Abandoned
2018
- 2018-06-22 CY CY20181100652T patent/CY1120355T1/el unknown
- 2018-06-26 HR HRP20180976TT patent/HRP20180976T1/hr unknown
2019
- 2019-04-02 US US16/372,940 patent/US11096982B2/en active Active
2021
- 2021-08-03 US US17/392,724 patent/US11963994B2/en active Active
- 2021-09-17 AR ARP210102590A patent/AR123542A2/es unknown

Also Published As

Publication number	Publication date
ES2672809T3 (es)	2018-06-18
MX2014007895A (es)	2015-03-19
RU2728789C2 (ru)	2020-07-31
ES2594856T3 (es)	2016-12-23
US20140235551A1 (en)	2014-08-21
EP2800749A1 (en)	2014-11-12
AR123542A2 (es)	2022-12-14
RU2016124658A (ru)	2018-12-04
US8716236B2 (en)	2014-05-06
CL2014001770A1 (es)	2015-04-17
IL242314A (en)	2016-08-31
RS57438B1 (sr)	2018-09-28
PT2800749T (pt)	2016-10-24
ZA201405535B (en)	2017-08-30
SG11201403784QA (en)	2014-08-28
UA114417C2 (uk)	2017-06-12
HRP20180976T1 (hr)	2018-08-10
AU2013202780A1 (en)	2013-07-18
HRP20161381T1 (hr)	2016-12-02
CA2861637C (en)	2017-07-18
US20220211797A1 (en)	2022-07-07
PE20142182A1 (es)	2015-01-16
JP2015199738A (ja)	2015-11-12
RU2016124658A3 (it)	2019-09-09
MX336294B (es)	2016-01-14
CN104159897A (zh)	2014-11-19
PH12014501534A1 (en)	2014-10-08
IL233386A0 (en)	2014-08-31
CN107915728A (zh)	2018-04-17
CA2861637A1 (en)	2013-07-11
JP5747137B2 (ja)	2015-07-08
BR112014016637A8 (pt)	2017-07-04
KR20180051646A (ko)	2018-05-16
RS55327B1 (sr)	2017-03-31
KR20150065960A (ko)	2015-06-15
NO2755614T3 (it)	2018-03-31
EP3133073A2 (en)	2017-02-22
DK2800749T3 (en)	2016-11-07
KR101917992B1 (ko)	2018-11-13
BR112014016637A2 (pt)	2017-06-13
KR101553792B1 (ko)	2015-09-16
AR089623A1 (es)	2014-09-03
US20130172264A1 (en)	2013-07-04
TW201333001A (zh)	2013-08-16
LT2800749T (lt)	2016-10-25
MY178390A (en)	2020-10-12
PH12014501534B1 (en)	2014-10-08
EP2800749A4 (en)	2015-08-05
NZ627480A (en)	2016-04-29
US9238675B2 (en)	2016-01-19
EP3133073B1 (en)	2018-05-02
US9586991B2 (en)	2017-03-07
CY1118371T1 (el)	2017-06-28
CY1120355T1 (el)	2019-07-10
IL233386A (en)	2016-08-31
HUE031305T2 (hu)	2017-07-28
SI2800749T1 (sl)	2016-11-30
LT3133073T (lt)	2018-06-25
ME03084B (me)	2019-01-20
US20190224269A1 (en)	2019-07-25
HK1203949A1 (en)	2015-11-06
BR112014016637B1 (pt)	2022-06-14
TWI503318B (zh)	2015-10-11
CO7020915A2 (es)	2014-08-11
CR20140367A (es)	2015-02-18
DK3133073T3 (en)	2018-06-18
PL2800749T3 (pl)	2017-01-31
MA35895B1 (fr)	2014-12-01
TR201808088T4 (tr)	2018-06-21
US20170136084A1 (en)	2017-05-18
PL3133073T3 (pl)	2018-09-28
CN107915728B (zh)	2021-04-30
JP2015504072A (ja)	2015-02-05
US20160102119A1 (en)	2016-04-14
RU2014130171A (ru)	2016-02-27
KR101855566B1 (ko)	2018-05-04
PH12015501038A1 (en)	2015-09-21
ME02526B (me)	2017-02-20
ECSP14011792A (es)	2015-12-31
EP3133073A3 (en)	2017-03-22
EP2800749B1 (en)	2016-09-21
US11096982B2 (en)	2021-08-24
RU2593259C2 (ru)	2016-08-10
US11963994B2 (en)	2024-04-23
AU2013202780B2 (en)	2015-04-16
KR20140107670A (ko)	2014-09-04
HUE037760T2 (hu)	2018-09-28
SI3133073T1 (en)	2018-06-29
PT3133073T (pt)	2018-06-18
WO2013103703A1 (en)	2013-07-11
PH12015501038B1 (en)	2015-09-21

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DK2895484T3 (da)	2022-05-09	Glucosylceramidsynthase-inhibitorer
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DK2873977T3 (da)	2020-06-08	Dobbeltdækker-rørdispenser
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DK2854722T3 (da)	2020-08-24	Stomipose
SMT201600357B (it)	2016-11-10	Inibitori di iap
DK2825157T3 (da)	2019-01-02	Aminosyrelipider
DK2831122T3 (da)	2016-05-17	Anthocyanidin-kompleks
DE112012006214T8 (de)	2015-04-16	Wulstringwickler
DE112012005566T8 (de)	2014-11-13	Seltenerdnanoverbundmagnet
FI20126082A (fi)	2014-04-19	Kaasunvaihtoventtiilijärjestely
DK2885638T3 (da)	2020-07-20	Molekylenet
DK2858657T3 (da)	2020-11-23	Feijoafrugtekstrakt
FI20126157A (fi)	2014-05-02	Laajentumistila
FI20125844A (fi)	2014-02-15	Talotekniikkamoduuli
ES1077590Y (es)	2013-04-25	Columbario
DE102013212400A8 (de)	2014-08-21	Abdeckplattenstützbaugruppe
FI20126108A (fi)	2014-04-26	Pankkorakenne
DK2897570T3 (da)	2020-01-20	Spin-elueringsrør
FI20126064A (fi)	2014-04-12	Leijupetilämmönvaihdin